Triglyceride Metabolism Jack Blazyk 3/1/04. Triglyceride Metabolism Triglyceride = Triacylglycerol =...

of 21/21
Triglyceride Metabolism Jack Blazyk 3/1/04
  • date post

    18-Jan-2016
  • Category

    Documents

  • view

    215
  • download

    0

Embed Size (px)

Transcript of Triglyceride Metabolism Jack Blazyk 3/1/04. Triglyceride Metabolism Triglyceride = Triacylglycerol =...

  • Triglyceride MetabolismJack Blazyk3/1/04

  • Triglyceride MetabolismTriglyceride = Triacylglycerol = Depot Fat

  • Triglyceride MetabolismLipogenesis occurs mainly in liver, adipose and intestinal epithelial cellsLipolysis occurs in adipose cellsRegulation via insulin and glucagon signals

  • LipogenesisR-COOHActivation

  • LipogenesisDHAP

  • LipogenesisGlycerol

  • LipogenesisCH2 CH CH2llOHOHGlycerol 3-P

  • LipogenesisPhosphatidic Acid

  • Lipogenesis1,2-Diacylglycerol

  • LipogenesisIntestinal epithelial cells Export via chylomicronsLiver Export via VLDLAdipose Storage in cytoplasm

  • Marks Basic Medical Biochemistry: A Clinical Approach (Williams & Wilkins, 1996)

  • LipolysisTriacylglycerolAdipose Cells

  • LipolysisAdipose Cells

  • Lipolysis2-MonoacylglycerolAdipose CellsFFA are transported via albumin

  • Regulation of LipolysisTriglyceride Lipase - OHACTIVEINACTIVEActivated by insulinActivated by glucagon

  • Regulation of LipolysisActivatorsGlucagonEpinephrineACTHTSHGrowth hormoneGlucocorticoidsThyroid hormones

    InhibitorsInsulinFree fatty acids

  • To see this presentation on the web go toClick on My TeachingThen click on Triglyceride Metabolismhttp://www.oucom.ohiou.edu/dbms-blazyk