TRIGEMINAL NEURALGIA (TGN) -...
Transcript of TRIGEMINAL NEURALGIA (TGN) -...
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TRIGEMINAL NEURALGIA
(TGN)
HANNO VIVIER
CAPE GATE MEDICLINIC
2017
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CONTENTS
• Definition
• Anatomy of the TRIGEMINAL NERVE
• Aetiology
• Clinical presentation
• Differential diagnosis
• Treatment
• Summary
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DEFINITION OF TGN
• Paroxysmal lancinating electrical shock like
pain confined to the distribution of one or
more branches of the trigeminal nerve (TN)
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ANATOMY & FUNCTION
• The trigeminal nerve has three divisions which enervate • The trigeminal nerve has three divisions which enervate the forehead and eye (ophthalmic V1), cheek (maxillary V2) and lower face and jaw (mandibular V3). It functions in sensing facial touch, pain and temperature, as well as controlling masticator muscles.
• The three divisions of the trigeminal nerve come together and forms the Gasserion ganglion which lies on the apex of the petrous bone in the middle fossa. From there, the motor and sensory nerve roots continues back and enters the the brainstem at the midpontine level. Within the brain stem, the signals travel to the trigeminal nerve nucleus.
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ANATOMY of Trigeminal Nerve
• picture
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AETIOLOGY OF TRIGEMINAL
NEURALGIA (TGN)
• Irritation/compression of the trigeminal
nerve at the root entry zone (brainstem)
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AETIOLOGY OF TGN
• Irritation/compression of the trigeminal
nerve at the root entry zone (brainstem)
– BLOOD VESSELS
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AETIOLOGY OF TGN
• Irritation/compression of the trigeminal
nerve at the root entry zone (brainstem)
– BLOOD VESSELS
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AETIOLOGY OF TGN
• Irritation/compression of the trigeminal
nerve at the root entry zone (brainstem)
– TUMOURS
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AETIOLOGY OF TGN
• In multiple sclerosis (MS) a plaque within the
brainstem may cause trigeminal neuralgia
(TGN)
– 2% of patients with MS have TGN
– 18% of patients with bilateral TGN have MS
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EPIDEMIOLOGY of TGN
AGE TYPICALLY > 50
Female: Male 1.8:1
unilateral 99%
bilateral 1% (investigate for MS)
DIVISIONS INVOLVED
V1 only 2%
V2 only 20%
V3 only 17%
V1 and V2 14%
V2 and V3 42%
All three 5%
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CLINICAL PRESENTATION
• Brief intense paroxysms of pain in one or
more divisions of the trigeminal nerve (TN)
– Intense stabbing/electrical shocks
– Lasting a few seconds
– Almost always unilateral
– 2nd or 3rd divisions of TN (mouth most common
site)
– More pronounced during the day (mostly pain-
free at night)
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CLINICAL PRESENTATION
• Attacks may be TRIGGERED by:
– Light cutaneous stimuli
– Shaving
– Washing
– Chewing
– Brushing their teeth
– Applying makeup
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CLINICAL PRESENTATION
• Characteristic:
Patient “guarding their face”
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CLINICAL PRESENTATION
• Characteristic:
There is a tendency for spontaneous remission
with pain-free intervals of weeks or months
(lack of any pain-free interval is atypical for
TGN)
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Characteristics NOT typical of TGN
• Sustained pain that is not paroxysmal
• Slowly developing pain that builds in
intensity and lasts for variable periods of
time (hours - days)
• Periorbital pain at night (cluster headaches)
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EXAMINATION
The exam should be NORMAL in TGN (except • The exam should be NORMAL in TGN (except very mild sensory loss)
• Any neurological deficits should prompt search for structural cause (e.g. tumour)– Assess sensation in all 3 divisions of TN (incl. corneal
reflexes)
– Assess masseter function (bite) and pterygoid function (opening mouth, chin deviates to weak side)
– Assess extra-ocular muscles (may indicate other associated cranial nerve deficits from tumour compression)
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UNNECESSARY DENTAL SURGERY
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DIAGNOSIS
Sweet et al identify 5 major clinical features thatSweet et al identify 5 major clinical features thatdefine the diagnosis of Trigeminal Neuralgia (TGN):
1. Pain is paroxysmal (“sudden, severe”)
2. The pain may be provoked by light touch tothe face (trigger zones)
3. The pain is confined to the trigeminaldistribution
4. The pain is unilateral
5. The clinical sensory examination is normal
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DIFFERENTIAL DIAGNOSIS
• Atypical facial pain syndromes• Atypical facial pain syndromes
• Herpes zoster
• Dental disease
• Sinusitis
• Orbital/Ocular disease
• Temporomandibular joint (TMJ) dysfunction
• Cluster headaches
• Temporal arteritis
• Glossopharyngeal neuralgia (throat & base of tongue pain radiates to the ear)
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FACIAL PAIN:DIAGNOSTIC APPROACH
– Site of the pain
Postherpetic Neuralgia
(usually V1 distribution)
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FACIAL PAIN:DIAGNOSTIC APPROACH
– Site of the pain
Atypical facial pain
(diffuse)
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FACIAL PAIN:DIAGNOSTIC APPROACH
– Site of the pain
Trigeminal Neuralgia
(V1,V2,V3)
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FACIAL PAIN:DIAGNOSTIC APPROACH
– Site of the pain
Dental disease
(around mouth)
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FACIAL PAIN:DIAGNOSTIC APPROACH
– Site of the painSinusitis: Maxillary or
frontal
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FACIAL PAIN:DIAGNOSTIC APPROACH
– Site of the pain
Cluster Headache
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FACIAL PAIN:DIAGNOSTIC APPROACH
– Site of the pain
Orbital disease (glaucoma)
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FACIAL PAIN:DIAGNOSTIC APPROACH
– Site of the pain
TMJ-disease
(anterior and posterior to ear)
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FACIAL PAIN:DIAGNOSTIC APPROACH
– Quality of the painTrigeminal neuralgia Sharp, stabbing, shooting, paroxysmal
Atypical facial pain Dull, persisting
Postherpetic neuralgia Dull, persisting, burning, occasional
paroxysm
Dental Dull
Sinusitis Sharp, boring, worse in the morning
Ocular Dull, throbbing
TMJ-dysfunction Severe aching, aggravated by chewing
Cluster headache Sharp, intermittent
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FACIAL PAIN:DIAGNOSTIC APPROACH
– Associated symptoms/signsTrigeminal neuralgia Often no neurological deficit
Atypical facial pain accompanying depressive illness in young or
middle aged woman
Postherpetic neuralgia Scarring, associated sensory loss
Dental Swelling of lips/face
Sinusitis Puffy appearance around eyes, percussion
tenderness over involved sinus
Ocular Visual blurring/haloes/visual loss
TMJ-dysfunction Tenderness over TMJ joint
Cluster headache Associated lacrimation/rhinorrhoea
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ATYPICAL FACIAL PAIN
– Diffuse, Dull, Persistent pain spreading over one
or both sides of the face (not in trigeminal
branch distribution)
– Often seen in young or middle aged woman with
the underlying depression
– Respond well to antidepressant therapy
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HERPES ZOSTER
– Frequently affects trigeminal territory (often V1
division) with painful ‘herpetic rash’ and corneal
involvement.
– The acute symptoms may resolve but lead to
chronic postherpetic neuralgia which slowly
improves
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HERPES ZOSTER
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CLUSTER HEADACHES
Characteristics:• Characteristics:� Males, severe unilateral orbital / supra-orbital
� Characteristic maneuvers that lessens the pain: sitting upright, rocking to and fro
• Common associations:� Conjunctival injection, lacrimation, nasal congestion, rhinorrhea, Transient
Horner’s Syndrome
• Duration: 30 min to 3 hrs
• Frequency of attacks: 1 – 8 attacks per day. (This typically happens 90 minutes after a person falls asleep)
• “Clusters” of attacks are separated by weeks or months
• Rx= Verapamil
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GIANT CELL (TEMPORAL) ARTERITIS
Clinical presentation– Severe throbbing headache overlying
the involved vessel in the elderly ptx
- Thickened, tender, non-pulsatile artery
- Jaw claudication (pathognomonic):
pain with chewing/talking
Diagnosis: raised ESR
Treatment: prednisolone
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SPECIAL INVESTIGATIONS –guided by
clinical suspicion
Blood tests• Blood tests
– ESR,FBC
• Dental x-rays
• CT Skull/Brain
• MRI Brain
– Exclude intracranial tumours or MS plaques, especially in cases with atypical features
– The yield in typical trigeminal neuralgia (TGN) patients is low
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TREATMENT
• MEDICAL
• SURGICAL DECOMPRESSION
• ALTERNATIVE PROCEDURES
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TREATMENT
• MEDICAL
– TEGRETOL (Carbamazepine)
• Complete or acceptable relief in 70%
• 100 mg BD, increase by 200 mg per day up to a
maximum of 1200 mg per day divided TDS
• Side-effects: drowsiness, rash (5 to 10%), leukopenia
(usually does not require discontinuing drug)
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TREATMENT
• MEDICAL
– LIORESAL (Baclofen)
• Second drug of choice
• Not as effective, but fewer side effects than Tegretol
• May be more effective when used in conjunction with
low-dose Tegretol
• 5 mg TDS, maximum dose 80 mg/day
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TREATMENT
• MEDICAL
– NEURONTIN (gabapentin)
• May act synergistically with Tegretol and Lioresal
• Side-effects: ataxia, sedation, rash
• 100 mg BD, maximum dose 3600 mg/day
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TREATMENT
• MEDICAL• MEDICAL– Other miscellaneous drugs which may be effective
• Phenytoin
• Clonazepam
• Lamotrigine (Lamictal)
• Amitriptyline (more commonly used for atypical facial pain)
• Botox (direct effect on the sensory nerve fibres)
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TREATMENT
• SURGERY
– Microvascular decompression (MVD)
• Indication: inadequate medical control or inability to
tolerate medical treatment
• Procedure of choice
• 95-99% Immediate Pain Control
• 75-80% Cure Rate
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TREATMENT
• SURGERY
– Vascular compression of the Trigeminal nerve
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TREATMENT
• SURGERY
– Microvascular decompression (MVD)
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TREATMENT
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ALTERNATIVE TREATMENT
(for high-risk surgical candidates)
• Peripheral nerve techniques
– Nerve block
– Avulsion of the supra-/infraorbital nerves
• Traumatising the trigeminal ganglion
– Glycerol
– Balloon inflation
– Radio-frequency thermocoagulation
• Stereotactic radiosurgery
– Trigeminal Nerve root entry zone (at the brainstem)
![Page 47: TRIGEMINAL NEURALGIA (TGN) - DocWebdocweb.co.za/docweb-files/send/45-2013-presentations/Trigeminal... · Within the brain stem, the signals travel to the trigeminal nerve nucleus.](https://reader030.fdocuments.in/reader030/viewer/2022020413/5b4d3e1d7f8b9a0d2d8b7d4f/html5/thumbnails/47.jpg)
ALTERNATIVE TREATMENT
Radio-frequency thermocoagulation
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SUMMARY
– History most NB: paroxysmal sharp electric shocks in
one or more branches of the TN, usually unilateral
– Characterised by sensory triggers, periods of
remission and initial response to Carbamazepine
(Tegretol)
– Neurological examination: Normal
– Aetiology: vascular compression of the trigeminal
nerve
– 75% will ultimately fail medical therapy and require a
procedure
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VIDEO