Proteasas de Fasciola hepatica PROTEASAS DE Fasciola hepatica.
Trematode Fasciola
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Transcript of Trematode Fasciola
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LP 8 Anul III 2013-2014
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Sistematică
PPD_p01 – Laboratory diagnosis methods: fecal examination
Regnul Animalia
Încr. Platyhelmintes Încr. NemathelmintesÎncr. Acanthocephala Încr. Artropoda
Cl. Trematoda Cl. Cestoda
Fasciola hepatica
Dipylidium caninum
Macracanthorhyncushirudinaceus
Trichocephalus spp.
Cl. Arachnida Cl. Insecta
Psoroptes communis
Bovicola spp.
HELMINȚI – helmintoze
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Încrengătura Platyhelmintes
•Cl. Monogenea•Cl. Trematoda•Cl. Cestoda•Cl. Turbellaria (planarii)
Monogenea Trematoda Cestoda
• ~ 100,000 specii estimate
• ~ 20,000 specii descrise
• ~ 80% au cel putin un stadiu parazitar
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•organisme metazoare, viermi plati, simetrie bilaterala, acelomate, majoritatea sunt HERMAFRODITE
• Majoritatea sunt parazite (ex. Monogenea, Trematoda, Cestoda)
• NU au cavitate, ap. circulator si resp.
• oxigen si nutrienti prin difuzie
• ciclu biologic complex, două sau trei gazde
Încrengătura Platyhelmintes
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Clasa Trematoda
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Clasa Trematoda - Subclasa Digeneaaparatul reproducător = HERMAFRODITE
• org. genitale masculine: 2 testicule
• org. genitale feminine: 1 ovar, 1 oviduct, 1 receptacul seminal, 2 gl. viteline, ootip, gl. Mehlis, uter
T – testiculeVd – canal deferentCs – punga cirusC – cirusPr – prostataSv – vezicule seminaleCga – orif genital
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CICLUL BIOLOGIC
VertebrateMoluste
Clasa Trematoda
GI GD
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Vertebrate sau nevertebrate
Moluste
Vertebrate
GI1
GI2
GD
Clasa Trematoda - Subclasa DigeneaCICLUL BIOLOGIC
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Familie Gen GD Organ Distributie
Fasciolidae Fasciola Ierbivore Ficat, cai biliare Worldwide
Fascioloides Cervidae, Bovidae Ficat, duoden, pulmon Europa, America de Nord
Fasciolopsis Porci, caine, om Intestin Asia
Parafasciolopsis Cervidae Ficat, cai biliare Europa
Dicrocoelidae Dicrocoelium Mamifere, Pasari Cai biliare, vezica biliara Mapamond
Paramphistomidae Paramphistomum Rumegatoare Stomac Emisfera nordica
Opistorchiidae Opistorchis Mamifere, Pasari Ficat, cai biliare, pancreas Mapamond
Clonorchis Mamifere Ficat, pancreas Asia
Schistosomatidae Schistosoma Om Vene Asia, Africa
Paragonimidae Paragonimus Mamifere Pulmon Mapamond
Diplostomatidae Alaria Mamifere Digestiv Mapamond
Heterophyidae Heterophyes Mamifere, Pasari Intestin Mapamond
Clasa Trematoda
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Fascioloza• boala importanta din punct de vedere economic
• paraziti localizati in caile biliare
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Regn Animalia
Încr. Platyhelmintes
Clasă Trematoda
Familie Fasciolidae
Gen: Fasciola
Specii: F. hepatica
F. gigantica
ETIOLOGIE - Sistematică
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ETIOLOGIE - Morfologie
Adultii (ficat)
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ETIOLOGIE - Morfologie
Adultii (ficat)
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ETIOLOGIE - Morfologie
Oua (fecale)
Galbenmaroniu
70–90 μm
opercul
130–145 μm
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ETIOLOGIE – Ciclul biologic
Mamifere ierbivoreMelci acvatici
Lymnaea palustris
Lymnaea peregra Lymnaea stagnalis
Lymnaea truncatula (Galba truncatula)
GI=melci acvaticiGD=ierbivore, omnivore
GI GD
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Paraziti adulti in canalele biliare
Ouale ajung prin canalul coledoc in
intestin
Oua eliminate prin fecale
Ouale trebuie sa ajunga in mediu
umed
Miracidiumul eclozioneaza
Miracidiumul cauta activ o gazda (melc)
Miracidiumul patrunde in melc
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Miracidiumul se transforma in
sporocist
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Sporocistul produce prima generatie de redii-fiice
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Prima generatie de redii produce a doua generatie
de redii
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Ciclul se reia si se formeaza sute de redii
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Fiecare redie se transforma intr-un cercar mobil
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Cercarul iese activ din corpul melcului
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Cercarii inoata si cauta vegetatia
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Cercarii urca pe vegetatie
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Cercarii se transforma in metacercari
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GD consuma vegetatie cu metacercari infestanti
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Parazitii tineri exchisteaza din metacercari
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Cai de migrare
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Cai de migratie
1. Peritoneu
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Cai de migratie
1. Peritoneu
2. Vase sanguine
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Cai de migratie
1. Direct
2. Cale circulatorie
3. Ascendent: canal coledoc
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Cai de migratie
1. Direct
2. Cale circulatorie
3. Ascendent: canal coledoc
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Cai de migratie
1. Direct
2. Cale circulatorie
3. Ascendent: canal coledoc
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EPIDEMIOLOGIE
- sezonier: toamna – iarna- terenuri umede
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TABLOUL CLINIC
• evolutie grava la ovine, mai putin grava la bovine
• formele tinere: forma acuta de boala (vara, toamna)
• adultii: forma cronica (iarna)
• Acut• sezonier• abdomen balonat, dureros la palpare, anemie, subfebrilitate, moarte• Moartea poate sa apara la 6 sapt de la infestare• Diferential - Clostridioza
• Cronic
• anemie, diaree, animale slab dezvoltate, icter,
edem submandibular, deglabratii, avort
• productie lactata redusa, lapte cu gust amar
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TABLOUL LEZIONAL – f. acutămicrohemorag. intestin
perihepatită fibrinoasă
hepatită hemoragico – traumatică ascitadg. dif. cisticercoză!!!
Fascioloza acuta - perihepatita
Andrei Mihalca © 2009
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TABLOUL LEZIONAL – f. cronică
Andrei Mihalca © 2009
Fasciolaza cronica - angiocolita, periangiocolita
Prezenta parazitilor adulti
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DIAGNOSTIC
Animale vii:
• simptome corelate cu sezonul
• oua cu aspect tipic in fecale (numai in forma cronica)
• ser: ELISA (2-3 sapt p.i)
Cadavre:
• leziuni tipice (perihepatita/angiocolita)
• prezenta parazitilor adulti
• f. acuta: evid. f. tinere → met. frământării ficatului + spălări sucesive - dg. dif. Dicrocoelium lanceolatum
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DIAGNOSTIC - Microscopic
Oua
Fecale: sedimentare
Numai in forma cronica!
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DIAGNOSTIC - Microscopic
Oua
In faza acuta:
Rezultat negativ!
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DIAGNOSTIC - Microscopic
Dg. microscopic diferential față de Paramphistomum