Clinical Utility of Sperm DNA Fragmentation Testing in Male Infertility Treatment
Treatment of The Hypogonadal Male
description
Transcript of Treatment of The Hypogonadal Male
![Page 1: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/1.jpg)
Treatment of The Hypogonadal Treatment of The Hypogonadal Male Male
William Abeyta MD
Associate Professor of Medicine
AVAH/UNM SOM
![Page 2: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/2.jpg)
OBJECTIVESOBJECTIVES
• Understand the clinical features of male hypogonadism.
• Discuss possible causes.
• Interpret laboratory tests and how to order them in different clinical scenarios.
• Review and describe the hypothalamic-pituitary-testicular axis.
• Understand general principles of treatment
![Page 3: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/3.jpg)
OBJECTIVES OBJECTIVES
• Describe the various testosterone preparations.
• Understand the monitoring required when using testosterone replacement.
• Identify complications of treatment.
![Page 4: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/4.jpg)
Why do we need testosterone?Why do we need testosterone?
• In men, testosterone plays a key role in the development of male reproductive tissues such as the testis and prostate as well as promoting secondary sexual characteristics such as increased muscle, bone mass, and the growth of body hair. In addition, testosterone is essential for health and well-being as well as the prevention of osteoporosis.
![Page 5: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/5.jpg)
![Page 6: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/6.jpg)
![Page 7: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/7.jpg)
HISTORYHISTORY
• Testosterone first used clinically in 1937, only 2 years after it’s Nobel Prize-winning discovery.
• Testosterone prescribing is escalating at startling rates creating a nearly $2 billion annual market.
• Surging off-label use (anti-aging, sexual tonic, bodybuilding or doping.
![Page 8: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/8.jpg)
HYPOGONADISMHYPOGONADISM
• Defined as the failure of the testes to produce androgen, sperm, or both.
• Testosterone production decreases with advancing age: 20% of men older than 60 and 30-40% of men older than 80 have serum testosterone levels that would be subnormal in their younger male counterparts.
![Page 9: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/9.jpg)
Case I
82 yo male presented to his new PCP with a chief complaint of back pain.The pain began suddenly when he helped move a pool table at the senior center onemonth prior to this visit. Despite worsening pain to the point that he could no longer walk very well, he had refused to come in for evaluation.He had no neurologic/bowel/bladder complaints
![Page 10: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/10.jpg)
Case I
Meds: APAP, viagra.Tobacco: 1PPD x 65 yearsETOH: none x 5 years, formerly heavy usePMH:
1. Right hip fracture with ORIF 2 years ago2. Esophageal stricture with multiple
dilations in the past.FH: neg for osteoporosis that he was aware of.
![Page 11: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/11.jpg)
Case IPE: normal vitalsNeck: no nodes or thyromegalyLungs: decreased BSs throughoutCV: RRR without M/R/GAbd: soft without hepatosplenomegaly or massesBack: Marked thoracic kyphosis with tenderness
at T12 and L1 Testicles: 5cm bilat, normal pubic hair
CXR: HyperinflationThoracic and lumbar spine films: compression
fractures of T12 and L1 appearing acute.
![Page 12: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/12.jpg)
Lab:Hct 38, MCV 95, nl WBC/pltsCalcium 9.2SPEP neg for paraproteinPSA <.03Normal TSH/prolactinFree testosterone 0.3 (11-25)Total testosterone 32 (241-827)
LH 14.1 (1-7)FSH 61.2(1.4-15) DXA: >4SD hip&spinePTH normal
![Page 13: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/13.jpg)
Case II
66 year-old male presented to his resident MDfor general medical f/u. He had been on testosterone injections for 2 years for primaryhypogonadism. His last Hct was one year priorand had been 50. The patient complained of fatigue, headaches, and dizziness.On exam his face appeared very flushed. Labtesting showed a Hct of 62%.
![Page 14: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/14.jpg)
HypogonadismHypogonadism
• Low levels of testosterone along with other specific signs and sxs. (diminished libido, ED, reduced muscle mass/bone density, depression, anemia)
• Affects 2-4 million males in the US.
![Page 15: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/15.jpg)
HypogonadismHypogonadism
• Only 5% of men currently receive rx
• Recent interest in rx d/t media attention, marketing of new preparations, “desire of baby boomers” to maintain vigor and health into their more mature years.
• Considerable controversy regarding indications for testosterone supplementation in aging males.
![Page 16: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/16.jpg)
HypogonadismHypogonadism
• No large-scale, long-term studies yet initiated to assess risks and benefits of testosterone-replacement rx in part d/t theoretical risk of possible stimulation of prostate cancer by testosterone.
• It is estimated that a study would need to include 6000 elderly hypogonadal men randomly assigned to receive testosterone or placebo for 6 years in order to determine whether rx increases risk of prostate cancer by 30%.
Snyder.Hypogonadism in Elderly Men-What ToUntil the Evidence Comes.N Engl J Med 2004;350:440-442
![Page 17: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/17.jpg)
![Page 18: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/18.jpg)
Gonadotrophins-FSH, LHGonadotrophins-FSH, LH
• Secreted by gonadotrophs in the anterior pituitary gland.
• FSH and LH secreted in pulsatile fashion. (pulsatile LHRH release results in pulsatile LH and FSH release).
• FSH has a longer half-life so levels fluctuate less throughout the day.
• Regulate testicular and ovarian function.
![Page 19: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/19.jpg)
Testicular Effects of FSH and LHTesticular Effects of FSH and LH
• LH controls testosterone production by Leydig cells.
• FSH in conjunction with intratesticular testosterone stimulates seminiferous tubules to produce sperm.
• FSH and LH required for sperm production but only LH necessary for testosterone production.
![Page 20: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/20.jpg)
The TestesThe Testes
• 60% of testicular volume accounted for by seminiferous tubules.
• Prepubertal testis 2cm in length and 2ml in volume.
• Testes average 4.6cm in length in adults but range from 3.5-5.5 cm according to Harrisons Textbook of Medicine.
• 4-7cm in UpToDate.
![Page 21: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/21.jpg)
TestesTestes
• Advanced age does not influence testicular size. (therefore significance of small testes is the same at all ages of the adult)
• Testis size varies among ethnic groups.
• Asian men have smaller testes than western Europeans, independent of differences in body size.
![Page 22: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/22.jpg)
![Page 23: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/23.jpg)
![Page 24: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/24.jpg)
![Page 25: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/25.jpg)
Serum Testosterone LevelsSerum Testosterone Levels
• Diurnal rhythm.• Values are 30% higher near 8am vs later in the
day.• Normal range varies among laboratories.• Usual range for young men is 300-1000ng/d.• In general values < 220-250 are clearly low in
most laboratories.• Values 250-350 should be considered borderline
low.
![Page 26: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/26.jpg)
Signs and Symptoms of Signs and Symptoms of HypogonadismHypogonadism
1. Diminished libido
2. Erectile dysfunction
3. Difficulty achieving orgasm
4. Diminished intensity of orgasmic experience
5. Diminished sexual penile sensation
![Page 27: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/27.jpg)
Signs and Symptoms of Signs and Symptoms of HypogonadismHypogonadism
Other
1. Diminished energy/sense of well being
2. Increased fatigue
3. Depressed mood
4. Anemia
5. Diminished bone density/muscle mass
![Page 28: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/28.jpg)
Risks of Testosterone-Risks of Testosterone-Replacement TherapyReplacement Therapy
1. Coronary Artery Disease: few if any data support a causal relation between higher testosterone levels and heart disease. High testosterone levels may actually have a favorable effect on the risk of CV disease. Studies have not demonstrated an increased incidence of CV disease or events such as MI, stroke, or angina. Rhoden, et al. Risks of Testosterone-Replacement
Therapy and Recommendations for MonitoringN Engl J Med 2004; 350:482-492
![Page 29: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/29.jpg)
Risks of Testosterone-Risks of Testosterone-Replacement TherapyReplacement Therapy
2. Lipid Profiles: Available data inconsistent (supraphysiologic doses appear to lower HDL).
Some variability may be explained by dosage.
Present data taken together suggest that testosterone replacement therapy within the physiologic range is not associated with worsening of the lipid profile.
Rhoden, et al. Risks of Testosterone-ReplacementTherapy and Recommendations for MonitoringN Engl J Med 2004; 350:482-492
![Page 30: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/30.jpg)
Risks of Testosterone-Risks of Testosterone-Replacement TherapyReplacement Therapy
3. Polycythemia: Higher testosterone levels act as a stimulus for erythropoiesis. Injections appear to be associated with a greater risk than topical preparations.
No testosterone-associated thromboembolic events have been reported to date.
![Page 31: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/31.jpg)
Risks of Testosterone-Risks of Testosterone-Replacement TherapyReplacement Therapy
4. BPH: Prostate volume DOES increase significantly during testosterone-replacement therapy (determined by ultrasonography) mainly during the first 6 months.
Poor correlation between prostate volume and urinary sxs.
Multiple studies fail to demonstrate exacerbation of voiding sxs attributed to BPH during testosterone supplementation.
![Page 32: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/32.jpg)
Risks of Testosterone-Risks of Testosterone-Replacement TherapyReplacement Therapy
5. Prostate Cancer: Prospective studies have demonstrated a low frequency of prostate cancer in association with testosterone-replacement rx.
Occult prostate cancer in men with low testosterone levels appears to be substantial with higher grade prostate cancers.
No compelling evidence to suggest men with higher testosterone levels are at a greater risk or that treating men who have hypogonadism with exogenous androgens increases this risk.
Rhoden, et al. Risks of Testosterone-ReplacementTherapy and Recommendations for MonitoringN Engl J Med 2004; 350:482-492
![Page 33: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/33.jpg)
*Prostate cancer becomes moreprevalent at the time of a man’slife when testosterone levels decline.
![Page 34: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/34.jpg)
Risks of Testosterone-Risks of Testosterone-Replacement TherapyReplacement Therapy
6. PSA: Studies have inconsistently shown a rise in PSA in testosterone treated patients (0.3-0.4ng/ml)
A substantial rise in PSA should arouse suspicion that a prostate cancer has developed.
![Page 35: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/35.jpg)
Risks of Testosterone-Risks of Testosterone-Replacement TherapyReplacement Therapy
7. Hepatic Effects: Oral preparations of testosterone reported to lead to hepatotoxic effects and neoplasia, including benign and malignant tumors.
IM injections and topical preparations of testosterone do not appear to be associated with hepatic dysfunction and routine monitoring of LFTs is unnecessary for men on these forms of replacement rx.
![Page 36: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/36.jpg)
Risks of Testosterone-Risks of Testosterone-Replacement TherapyReplacement Therapy
8. Sleep Apnea: Testosterone-replacement therapy has been associated with the exacerbation of sleep apnea or with the development of sleep apnea (Seen in men treated with higher doses of parenteral testosterone and have other risk factors for sleep apnea). Probably by central mechanisms rather than by anatomical changes in the airway.
![Page 37: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/37.jpg)
Miscellaneous Effects of Miscellaneous Effects of TestosteroneTestosterone
• Breast tenderness and swelling• Testicular size and consistency diminish• Fertility is diminished• Skin reactions with topicals• Pain, bruising, soreness, furuncles with
testosterone injections• Fluid retention• Acne, oily skin• No data to suggest acceleration of male-pattern
baldness.
![Page 38: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/38.jpg)
Evaluation of the Possible Evaluation of the Possible Hypogonadal MaleHypogonadal Male
Physical exam: focus on whether or not sexual development is consistent with the patient’s age.
• Testicular size: 4-7cm in length.• Normal musculature• Dense pubic hair and in a diamond pattern.• Beard should be full and dense• Chest and other body hair should be present.
![Page 39: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/39.jpg)
Laboratory TestsLaboratory Tests
Serum Testosterone Measurement:
• Am total serum testosterone level
• Check free testosterone level in obese males and older males.(changes in SHBG)
• Repeat measurement if low or borderline level of testosterone
![Page 40: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/40.jpg)
Low Testosterone LevelLow Testosterone Level
• Measure FSH and LH
• Prolactin level
• TSH
• MRI of Pituitary if FSH/LH low or not elevated?
![Page 41: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/41.jpg)
Who To Treat With Testosterone-Who To Treat With Testosterone-Replacement Therapy?Replacement Therapy?
• Testosterone should be given ONLY to a male who is hypogonadal as evidenced by a low testosterone level.
• There is insufficient evidence that testosterone benefits elderly males without clearly abnormally low testosterone levels.
Liverman. Testosterone and aging:Washingon DC:NationalAcademies Press.
![Page 42: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/42.jpg)
Baseline Exam/Tests Before Baseline Exam/Tests Before Beginning Treatment With Beginning Treatment With
TestosteroneTestosterone
• Voiding history
• History of sleep apnea
• Perform DRE
• Baseline PSA and HCT/hemoglobin
• GU referral if PSA over 4.0 or abnormal prostate exam
![Page 43: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/43.jpg)
Testosterone PreparationsTestosterone Preparations
1. Testosterone Esters: injectable testosterone
2. Transdermal:
Nonscrotal patch
Testosterone Gel
Ointment
Solution
3. Buccal tablet
4. Pellet (Testopel Implant)
![Page 44: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/44.jpg)
Testosterone EstersTestosterone Esters
Testosterone Esters: Injectable testosterone
• Testosterone enanthate and cypionate used for years in treatment of testosterone deficiency.
• Begin with 200mg IM every 2 weeks.
• Can change to 100mg every week if fluctuations in libido, mood, energy.
![Page 45: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/45.jpg)
Testosterone Esters: Injectable Testosterone Esters: Injectable testosteronetestosterone
• Measure testosterone midway between injections and value should be mid-normal (600-700ng/ml)
• Reduce dose if higher values obtained.
• Disadvantage is fluctuations in mood, energy and libido in many patients
![Page 46: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/46.jpg)
Nonscrotal PatchNonscrotal Patch
• One body patch is available (Androderm)
• Worn on arm, torso, or thigh
• Start with 4mg patch
• Can check serum testosterone level at any time
![Page 47: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/47.jpg)
Testosterone GelTestosterone Gel
• Apply once per day
• Takes a month to reach normal levels and remain steady throughout 24 hours.
• Can check serum level at any time of day
![Page 48: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/48.jpg)
Buccal TabletBuccal Tablet
• Approved by FDA June, 2003 (Striant)
• Applied and adheres to a depression in the gum above the upper incisors and releases testosterone across the buccal mucosa
![Page 49: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/49.jpg)
COST $$$$COST $$$$
Testosterone cypionate inj 1ml (200mg) $10.14 ($20.28/month)
Testosterone 2 mg patch (1) $7.06
4mg patch (1) $14.11
($211.18/month and $423.30/month)
![Page 50: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/50.jpg)
Cost $$$$Cost $$$$
Testosterone gel 1% 1.25GM/ACT (75GM) $212.62/month
Testosterone gel 1.62% 20.25mg/ACT(75GM) $412.40/month
Buccal testosterone 30mg (60) $517.50/month.
![Page 51: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/51.jpg)
Follow-up of The Testosterone-Follow-up of The Testosterone-Replaced MaleReplaced Male
• Follow-up visit in 2-3 months for efficacy evaluation
• Assess urinary sxs/sleep apnea
• Perform DRE at ~3 months and q year thereafter
• Testosterone level at 2-3 months
• PSA at 3 months and q year thereafter
• HCT at 3 months and than yearly
![Page 52: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/52.jpg)
WHAT’S NEW?WHAT’S NEW?
“Gonadal Steroids and Body Composition, Strength, and Sexual
Function in Men” NEJM 369;11, September 12, 2013
![Page 53: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/53.jpg)
MethodsMethods
• 198 healthy men 20-50 years of age given goserlin to suppress endogenous testosterone and estradiol.
• Randomly assigned to receive placebo gel, or testosterone gel in different doses daily for 16 weeks.
• Another 202 healthy men received goserline, placebo gel or testosterone gel and anastrozle to suppress conversion of testosterone to estradiol.
• Primary outcomes were changes in percentage of body fat and in lean mass.
• Thigh muscle area and strength and sexual function also assessed along with subcutaneous and intraabdominal-fat areas.
![Page 54: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/54.jpg)
ResultsResults
• % of body fat increased in groups receiving placebo or low dose of testosterone daily without anastrozole.
• Lean body mass and thigh-muscle area decreased in men receiving placebo and in those receiving low dose testosterone daily without ansatarozole.
• Leg press strength fell only with placebo administration.
• In general, sexual desire declined as the testosterone dose was decreased.
![Page 55: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/55.jpg)
ConclusionsConclusions
• The amt. of testosterone required to maintain lean mass, fat mass, strength, and sexual function varied widely in men.
• Androgen deficiency accounted for decreases in lean mass, muscle size, and strength.
• Estrogen deficiency primarily accounted for increases in body fat.
• Both testosterone deficiency and estrogen deficiency contributed to the decline in sexual function.
![Page 56: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/56.jpg)
Summary: Endocrine Society Summary: Endocrine Society Clinical Practice Guidelines for Clinical Practice Guidelines for
testosterone replacement therapy.testosterone replacement therapy.
• Diagnosis of androgen deficiency only in men with consistent symptoms and signs with unequivocally low serum testosterone levels.
• Measure morning total testosterone.
• Confirm with repeat total testosterone and free or bioavailable testosterone using accurate assays
![Page 57: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/57.jpg)
Guidelines continuedGuidelines continued
• Do not start testosterone therapy in patients with breast or prostate cancer,
palpable prostate nodule or induration or PSA >3 without urologic evaluation.
Severe LUTS
HCT >50%
Untreated OSA
Severe CHF
![Page 58: Treatment of The Hypogonadal Male](https://reader035.fdocuments.in/reader035/viewer/2022062305/56815118550346895dbf37d2/html5/thumbnails/58.jpg)
CASE I AND II REVIEW