Tre1 GPCR initiates germ cell transepithelial migration by regulating E-cadherin

Prabhat S. Kunwar, Hiroko Sano, Andrew D. Renault, Vitor Barbosa, Naoyuki Fuse, and Ruth Lehmann

J. Cell Biol.Volume 0(2008):1-f-12

September 2, 2008

© 2008 Kunwar et.al.

Figure 1. Live imaging of germ cell migration through the midgut in wild-type and tre1 mutant embryos

Kunwar et al. J. Cell Biol. 2008:0:1-f-12

© 2008 Kunwar et.al.

Figure 2. Gβ13f and Gγ1 act downstream of tre1 in transepithelial migration

Kunwar et al. J. Cell Biol. 2008:0:1-f-12

© 2008 Kunwar et.al.

Figure 3. Tre1 regulates germ cell polarization and G protein localization

Kunwar et al. J. Cell Biol. 2008:0:1-f-12

© 2008 Kunwar et.al.

Figure 4. DE-cadherin is required for germ cell–germ cell adhesion

Kunwar et al. J. Cell Biol. 2008:0:1-f-12

© 2008 Kunwar et.al.

Figure 5. tre1 regulates DE-cadherin localization in the tail of germ cells

Kunwar et al. J. Cell Biol. 2008:0:1-f-12

© 2008 Kunwar et.al.

Figure 6. Reduction of DE-cadherin function or adhesion between germ cells does not rescue the tre1 phenotype

Kunwar et al. J. Cell Biol. 2008:0:1-f-12

© 2008 Kunwar et.al.