Transgenic Animalsftp.tugraz.at/pub/Molekulare_Biotechnologie/MOL_911 Molecular... · Transgenic...
17
Transgenic Animals
Transcript of Transgenic Animalsftp.tugraz.at/pub/Molekulare_Biotechnologie/MOL_911 Molecular... · Transgenic...
Transgenic Animals
Transgenic Animals
Transgenic Animals
Transgenic Animals
Transgenic Animals
“Cloning”
Transgenic Animals
Transgenic Animals
Tissue specific Expression
CFTR: Cystic Fibrosis Transmembrane Conductance Regulator
Transgenic Animals
Tissue specific Expression
Transgenic animals as organ supplier
Immunological Barriers
Hyperacute rejectionAcute vascular rejectionCellular rejectionChronic rejection
Porcine endogenous retroviruses
Humanizing the pig:
Introduction of Human Genes
Knock out of pig genes -1.3 galactosyltransferase avoid immunogenic reaction