TRANSCRIPT & APPLICATION GUIDE OF 7-EPISODES AND Q&A...

TRANSCRIPT & APPLICATION GUIDEOF 7-EPISODES AND Q&A 1-2

EPISODE 1 THE AUTOIMMUNE

EPIDEMIC: ROOT CAUSES AND SOLUTIONS

Betrayal•Episode1-TheAutoimmuneEpidemic:RootCausesandSolutions

Dr.O'Bryan:[00:00:30]

Hello.ThisisDr.TomO'Bryan.WelcometoBetrayal:TheAutoimmuneSolutionThey’reNotTellingYou.Iamabouttotakeyouonajourneyaroundtheworlddiscoveringtheunderlyingmechanismtopracticallyeverydegenerativediseasetocardiovasculardisease,tocancers,practicallyeverydisease.Whydoesitappearthatourbodiesarebetrayingusandwegetsick?You'reabouttodiscoverthecauseofautoimmunediseaseanditstruesolution.ThisisBetrayal:TheAutoimmuneSolutionThey’reNotTellingYou.

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You’regoingtolearnfromovereighty-fiveoftheworld’sforemostexpertsincludingscientificresearcherswhoareconsideredthefathersandthegodfathersinthefieldofautoimmunity.Importantly,you’llhearfrompeoplethathaveturnedtheirautoimmuneconditionsaroundandfoundoptimalhealth.Thesearedire,life-destroyingconditionsthatmostpeopleneverrecoverfrom:Lupus,colitis,Crohn’s,MS,rheumatoidarthritis,diabetes,skinconditionslikepsoriasis,andalsodegenerativebraindiseasesincludingAlzheimer’s,Parkinson’s,anddementia.

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You’reabouttofindoutwhatthetruerootcausesaretotheseterriblediseases.Whatturnsyourbodyontodevelopadisease,aswellaswhatyoucandotopreventthemfromhappeningtoyou.Ifyouoralovedoneissufferingfromaspecificautoimmunedisease,you'reabouttolearnthespecificprotocolsyoucanusetostopitinitstrack,reverseit,andtotallytakeawayyoursymptoms.

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Thisisnotjusttheory.You’lllearnfromdoctorswhohavesuccessfullytreatedpatientswiththesepowerfulapproachesandpatientswhohavereversedlife-threateningautoimmunediseasesthemselves.You’llbediscoveringtherealtruthbehindwhylosingweighthasbecomeliterallyimpossibleforsomany.You’llseewhysomanysuffertheshameofexperiencingdrastichairloss.You’llunderstandwhypeoplearegettingskindisordersthatcan’tbeexplainedbyconventionalmedicine,muchlesstreated.You’llalsoseewhyyourmemorymaybegettingsobad.

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IwishIcouldtellyouthatyoucouldknockonyourlocaldoctor’sofficeandgettheanswersbut,unfortunately,thestatisticsshowusthattherootcausesandtruesolutionsareveryrarelycomingfromthesesourcesofauthority.Thebrutalrealityis,onautoimmunedisease,modernmedicinedoesn’thavetheanswers.Sadly,somethinglikegutbacteriahasbeenunderstoodassomethingtobegottenridofbydoctors,andthisonefalseparadigmhasputusinanautoimmunehellwheremanyofushavelostourbestfriendindefendingagainstdisease,ourgutmicrobiome.

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Industriesbentonfinancialgainattheexpenseofliveshavereleasedharmfultriggersintoourenvironmentanddestructivesubstanceshavebeenaddedtoourfood,ourwater,andtheproductsweuseeachday.You'realsogoingtolearnthethingsthatthey'redoingtousthatarecausingthisslewofsymptoms.Thetruthisautoimmunediseasedestroyslives.Ittakesusawayfromourlovedones,stopsusfromexperiencingthemostpreciousmomentsinlife.Itleavessomayvibrant,


loving,andambitiousmen,andwomen,andchildrenlockedbehindcloseddoorsinpain,debilitated,andashamedforwhat’shappeninginsidetheirbodiestheycan’texplain.Noonecouldexplainit.

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InordertobringyouBetrayal,I'vehadtheprivilegeofteamingupwiththeexperiencedfilmanddocumentarydirectorandproducer,JonathanOtto.JonathanhasdialeddownonthissubjectmorethanIcouldhavehopedfor,andhehasdedicatedhislifetoalleviatingsufferingthroughhiswork,andhasaprofoundabilitytounderstandandcapturewhatthetrueimpactofautoimmunediseasereallyis.Hebelievesthatit’stimefortheworldtoseewhatfamiliesareexperiencing,thepainandsuffering,aswellasthejoyandfulfillmentthatcomesthedaythatyouturnyourconditionaround.

[00:04:00] JonathanandI,withourfilmcrew,haveteamedtogetherandtraveledacrossthecountryandallaroundtheworld,throughEngland,andPortugal,andGermany,andSpain,andBraziltogatherthestories,pullbackthecurtainsandthelies,andrevealthetruthaboutautoimmunedisease.

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HereonEpisode1,you'regoingtolearnfromtheexpertswhatisautoimmunedisease.You’llmeettheGodfatherofPredictiveAutoimmunityfromIsrael,ProfessorYehudaShoenfeld.You’llmeettheGodfatherofFunctionalMedicine,Dr.JeffreyBland.Dr.MarkHymanwhochairstheeffortoftakingfunctionalmedicinetoClevelandClinic.Microbiomeexpert,Dr.MichaelAshfromEngland,andmanymore.We’reabouttobreakthesilenceonthisheartbreakingpackageofdiseases.Getready.Herewego.

Dr.MarkHyman:[00:05:00]

Theautoimmuneisawholespectrumofdisordersthatallhaveverycommonroots,evenwhentheyshowupindifferentpartsofthebody.Ifyoulookatautoimmunity,itaffects80millionpeopleinthiscountry.YoulumpthemaltogetherfromHashimoto’sthyroiddisease,toMS,toinflammatoryboweldisease,toarthritis,topsoriaticarthritis.Awholespectrumofdisordersareseenoftenasveryseparatethings,butwenowknowthatautoimmunityhascommonrootsthatisthebodyattackingitself,andthatthere’sareasonforit.Unfortunately,mostcommontherapiesaredesignedtosuppressorblockthebody’sownimmunesysteminsteadoffiguringoutwhyit’ssopissedoffinthefirstplace.

[00:05:30]Dr.JeffreyBland:

It’sgenerallyknown,theconceptofautoimmune,isthattheimmunesystemisreactingagainstthebodyitself.It’slikeanautomaticprocessofthebodyrejectingitself.Itreallyseemslikethat’saverystrangethingforourimmunesystemtoturnrogueagainstourhosttissuesandstarttodamagethem.

[00:06:00] Really,fordecades,forme,infact,Icansaygoingbackcertainlyintothe‘60sinmybackground,I'vealwayswonderedabouttheterm“autoimmune.”Itjustdidn’tseemreasonablethatsuddenlyanimmunesystemthatwastheretoprotectusagainsttheoutsideworldsuddenlyturnsrogueandstartsattackingourselves.Therehadtobeaprecipitatingevent.Therehadtobesomethingitseemedthat


wouldtranslategoodnesstocollateraldamagetoourbody.[00:06:30][00:07:00]

ThemorethatIgotthinkingaboutthat,themoreIstartedaskingmyself,“Whatarethediagnosticcriteriathatareusedforpickingouttheseconditionslikerheumatoidarthritis,ormultiplesclerosis,orsystemiclupuserythematosus,ormyastheniagravis,orthyroiditis,andthere’s88differentdiagnosesfortheseconditionsthathitdifferenttissuesinourbody,andkeepallergists,immunologists,andinternistsverybusybecauseyou’vegotallthesehostofdifferentdiagnosesoftheimmunesystemofourbodyturningrogueagainstspecifictissuesthatthengivestothesedifferentdiagnoses.

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Ithought,howdowediagnosethis?They'rediagnosedbylookingatthepresenceofwhatarecalledautoantibodies.Ithought,whatisanautoantibody?Wesay,it’sanantibodythatourimmunesystemproducesagainstourowntissuelikeanti-thyroidautoantibodies,oranti-mucosalantibody,oranti-brainlipidantibodywithrespecttomultiplesclerosis.Ithinkourbodiesactuallylookatthesenativepartsofourplumbingandourmachinery,andit’ssaying,“I’msorry.Suddenly,you'reaforeignerandIamgoingtoproduceadisruptivethingfrompartofmyimmunesystemcalledtheBcellsthatisgoingtoattackthosetissuesspecifically.”

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Then,I'vegotthinkingthisalittlefurther.Waitaminute.Arewesurethatthosetissuesthatwesaytheimmunesystemisrespondingtoarethehosttissuesthatwerethesameaswhenthosetissueswerefirstgeneratedoristheresomethinggoingonthatmakesthosetissueslooklikethey'reaforeigner?ThatlittlequestionthatIhadwhichstartedasavirusinmycentralnervoussystemsomewhereinthe1980sjustcontinuedtofulminateasIwasreadingtheliteratureandthinkingaboutit,untilIfinallycametothebeliefthatourbodyactuallydoesn’trespondtoitself.It’srespondingtosomethingthathappenstoourbodythatmakesitanon-self.Now,thatisaparadigmshiftingconcept.

Dr.LizLipski:[00:09:00]

Frommyeyes,it’samisfirebetweenwhatourimmunesystemwantstodoandwhatitshouldbedoing.Sometimes,itseemstomealmostlikethatwhenweliveinamorepristine,moretraditionalculturewhereweliveclosetotheearth,andwherewehadparasites,andwhereweeatfoodthatwasfresh,andwedidn’thaverefrigerators,andthingsspoiled,theimmunesystemhadalotofreallygoodthingstodo.Now,theimmunesysteminourmodernculturefeelstomealotlikeagroupofteenagerswithtimeontheirhands.

Dr.TomO’Bryan: That’sagreatanalogy.Surelygood.

Dr.LizLipski:[00:09:30][00:10:00]

Theygetintomischiefbecausetheydon’thavetheiroldjobstodo.Also,theimmunesystem,ifyoulookatPollyMatzinger’swork,it’saboutnotjuststrangersbutdangerousstrangers.Whenwewalkdownthestreetorwewereinaconferencelikewearehere,therearealotofstrangersbutwethinkthey'refriends,they'renotdangerousstrangers.Theimmunesystem’sjobisnottoreactmostofthetime,andwe’reexposedtotoxins,weeatfoodsthatareunusual,we’restressedout,wehavemolds,wehaveallkindsofunusualsituationsthatarereallydifferentthaneven150yearsago.


Theimmunesystem,itjustoverreacts.Sometimes,theysayit’slikeit’syour

birthdayandeverybodyissingingHappyBirthday,andyoucutthecake,andthecandlesarelit,andeverybodyisexpectingyoutoblowtothecandles,andyouwhipoutyourfireextinguisher.That’sanautoimmunedisease.It’sanoverreactionoftheimmunesystemtosomenormalevent.

[00:10:30]Dr.TerryWahls:[00:11:00]

Autoimmunityistheprocesswheretheimmunecellsbeganattackingselfandattackingnormal,healthy,vibranttissuecausingdamage.Overtime,we’vebeenconvertingmanyofourchronicdiseasesintopossiblyimmune,probablyautoimmune,andthendefinitelyautoimmuneinnature.Iwouldpredictthatinanother20-30years,thevastmajorityofourchronicdiseaseswillhavebeenreclassifiedasprobablyautoimmuneinnature.

Dr.O'Bryan: Whenisitnormalfortheimmunesystemtobeattackingself?

Dr.TerryWahls:[00:11:30][00:12:00]

Theimmunesystem,ourimmunecellshaveveryimportantfunction.They'reinvolvedinmaintainingandrepairingthebody.IfIover-trainedandIdamagedmymusclesfromoveruse,myimmunecellshavetocomein,anddissolvethatdamage,mopitup,andrepair.IfIhavetrauma,myimmunecellshavetocomeinandrepairthattraumaorifIamdamagedfrominfection,theywill,again,comein,mopupthedamage,andrepair.They'reavitalpartofmaintenanceandrepairofeverydayandacutedamage.Whenitbecomespathologiciswhenthey'reattackinghealthytissueorwhenduringtherepairphasethatattackcontinuesoncetherepairhasbeencomplete.

Dr.O'Bryan: That’sabrilliantoverviewofthefunctionoftheimmunesystem.Noneofourguestshavetalkedabouttherepairphase.Thatexplainswhysometimes,youhavetobeabletogetridoftheolddamagedcells.

Dr.TerryWahls: It’svital.Weneedtodothatwhenthere’sdamagefrominfection,fromtrauma,fromoveruse.

Dr.O’Bryan: Orevenexerciselikeabicep.

[00:12:30]Dr.TerryWahls:

Absolutely.Whenwestrengthstrain,weareintentionallydamagingourmusclesjustabit.Ourimmunecellshavetocomein,repairthedamage,andrebuildastrongermusclecell,astrongertendon,astrongerbone.It’savital,vitalpartofourongoinghealthyvitality.

Dr.O'Bryan:[00:13:00]

It’sagoodthingfortheimmunesystemtobegettingridofouroldcells,ourdamagedcells,butthen,itgetstobethreateningwhentheimmunesystemisgettingridofmorecellsthanitshouldbe.

Dr.TerryWahls: Correct,whenit’sgettingridofcellsthatareotherwisehealthyandvital.Forexample,I'vedevelopedanimmuneresponsetoaninfection,we’veclearedoutthatinfection,thatcloneshouldbewipedoutandeliminated.


Dr.JohnCline:[00:13:30]

Ifyouthinkofourdefensesystem,it’stheretoprotectusfromforeigners,tryingtogetinorthosethatgetin,andalsotoprotectusfromthingsthatgowronginsideourcells.Wehavetohaveawayofdistinguishingselffromnon-self.Whenthat’sworkingwellandourdefensesystemisdoingitsjob,then,everythingjusthumsalongjustlikeridinginaRollsRoyce.

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Therearecertainthingsthatoccurinourlivesthatstarttointerferewiththatabilityforustodistinguishselffromnon-self.Whenthedefensesystemorwhatwecalltheimmunesystemstartstolosethatability,thenitstartstoreactorattackthingsthatitshouldn’tbeattackinglikeself.That,tome,isautoimmunity.

Dr.O'Bryan:[00:15:00]

Thelackofawarenessontheunderlyingautoimmunemechanismcreatesbothatragedyofprematuredeath,aswellaspeoplebeingrobbedofthequalityoflifethat’simportanttousall.Haveourimmunesystemsbetrayedus?Theanswertothatquestionwillshockyou.Peoplearelookinginthewrongdirectionwhensearchingforthesolutionsofautoimmunediseases.We’requiteliterallyinthedarkagesandthinkingthatthisisallaboutgeneticsandmedication.Youwilllearnmoreaboutthatintheupcominginterviewswithworldexperts.

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Inthisseries,you'regoingtolearnsomeinformationintheupcomingepisodesonthatverytopicsoyoucanfindwhatthetrueenemyisandhowyoucanensurethatyourbodyisneverattackingitself.Howwidespreadreallyisthisissue?Howmanypeoplearetrulyaffectedbythisvillainousgroupofdiseases?Whataboutothercountries?You'reabouttofindoutsomeimportantanswerstothesequestionsthatwillbringyouanawarenessofwhatautoimmunediseaseactuallyisandwhatyoucandoaboutit.

Dr.MichaelAsh:[00:16:00]

Anautoimmunediseaseisnolongerasilentkiller.It’severywhere,some70or80millionpeopleintheUSarecurrentlydiagnosed,oreitherdiagnosedoryettobediagnosedwithautoimmunedisease.AcrossEurope,thenumbersofAIorautoimmunediseaseinstancesareincreasingovertime.

Dr.O'Bryan: Dr.Ash,canyoutellushowwidespreadthisissuetrulyis.

Dr.MichaelAsh: Certainly,forNorthAmerica,theNIHsuggestsit’s24millionpeopleintheUSarebeingdiagnosedwithautoimmunediseasebuttheyalsopointoutthatperhapsonlyoneinthreethatarethey'rebeingpickedup.Let’ssaybetween70and80millionpeopleinNorthAmericacurrentlyhaveautoimmunedisorders.

[00:16:30]Dr.DavidBrady:

Ifyoutakeaclassicautoimmunediseasemodellikeinflammatoryboweldisease,ulcerativecolitis,orCrohn’sorsomethingakintothat,thebestestimatesandwhattheincidencewasintheWesternworld,likelet’ssayinUnitedStatesattheturnofthe20thCenturyin1900,itwasabout1in10,000individuals.Now,it’s1in250.250.That’sanunbelievablechangeinaveryremarkablyshortamountoftimefromanevolutionaryperspective.It’snotthatourgeneschangedthatmuchinahundredyears.


[00:17:00]Dr.O'Bryan:

Thisiswhyyoucallitamodernepidemic.

Dr.DavidBrady:[00:17:30]

Itisamodernepidemicandit’sreallymostlyacuteinthelast30years.Whenyouthinkabouthowmuchourenvironmenthaschanged,howmanynewchemicals,howmanynewpesticides,andherbicides,andflameretardants,andamillionchemicalsthatarerespondstoamountoffiresinthebody.Weknowthereareendocrineorhormonaldisruptorsbuttheycoulddisruptalotofdifferentmetabolicprocessesinthebody.Weknowthatcertaintoxins,particularly,forinstanceliketransitionalmetalslikemercury,andlead,andthingslikethat,theycanactuallyglobontosulfurunitsontheendofourhostproteins,ourowntissue.Now,theimmunesystemlooksatthatproteinassaforeignprotein.Itlooksatitasahapten,andnowyougetanautoimmuneresponseagainstyourowntissuebecauseofatoxin.

Dr.AmyMyers:[00:18:00][00:18:30]

It’sincreasedthreefoldoverthelast50years.Therearesomewherebetween50and75millionAmericanswithautoimmunitythathavebeenactuallydiagnosedanda150millionworldwide.Thosearethepeoplethatknow.Inautoimmunity,theseantibodiesarethoughttocomeoutatleastfiveyearsbeforetheactualdiseasedoes.Ittakespeoplesixtotendoctorstoactuallydiagnosed.Thisautoimmuneprocessisgoingonwellbeforeit’sgottentothepointwheresomeonehasovertdisease.It’shundredsofmillionsofpeoplewithautoimmunityorthatarewhatIcallonmybook,beingonthisautoimmunespectrumofhavingtheseantibodiesbutnothavingdiagnosedwithfull-blowndiseaseyet.

Dr.TomO’Bryan:[00:19:00]

Youtalkedaboutthedamagebuildingup,andtheneventually,thesymptomswilloccur.Thatdamageisaperiodwheretheantibodiesareelevated.They’reattackingthetissuebuttherearenosymptoms.That’stheprodromalperiod.We’vespokenbeforeabout,MelissaArbuckleStudylookingatlupuspatientsintheVAandhowshefoundthateverysinglelupuspatienthadthosesevenantibodiesoflupus,allsevenofthemelevatedyearsandyearsbeforetherewaseverasymptom.Theideaoflookingtosee,isthereanautoimmunemechanismgoingonwhilethepersonmayfeelfine?Whatdoyouthinkaboutthatconcept?

[00:19:30]Dr.SarahBallantyne:

Ilovetheideaofhavinganearlywarningbecauseknowingwhetherornotwehaveantibodiesthatmightpredisposeusorthatmightbetheearlysignsofadevelopingautoimmunedisease,thatgivesustimetostartdealingwithalloftheenvironmentalfactorsthatwehaveagreatamountofcontroloverthatarealsocontributorstothatdisease.Autoimmunediseaseisnotjustaboutanautoantibodyforminganantibodythatcouldattackourbodies,butit’salsoaboutanimmunesystemthatcan’tregulateitselfthat’soverstimulatedtoattack.

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Thatoccurswhenwe’renotgettingenoughnutrientsinourdiets,whenwe’restressed,whenwe’renotgettingenoughsleep,whenwehavegutdysbiosisandleakygut,whenwe’reconsumingfoodsthatwe’rehavingintolerantreactionstothatareprimingtheimmunesystem,orwe’reconsumingfoodsthatarehighly


[00:20:30]

inflammatory.Itcanhappenwithinfection.Itcanhappenwithtoxinexposure.Whenwecanhavethatwarning,“Hey,look,somethingbadisgoingtohappendowntheroad,”it’ssimilartohowpre-diabeticsknowthattheyneedtochangedietandlifestyletoavoidtype2diabetes.It’sthesamething.Itgivesusthatabilitytostartmakingchangesandpreventthediseasefromdeveloping.

Dr.KellyBrogan: Ifirstawoketothepossibilityofputtingachronicautoimmunediseaseintoremissionthroughmyownexperienceasit’salmostalwaysthecasefordoctorswhogorogue.Theydosobecausetheyhavehadanexperiencethathadshownthemagreaterversionofthetruththantheywereexposedtothroughtheirpharma-fundededucation.

[00:21:00] IwasdiagnosedwithHashimoto’spostpartumaboutninemonthsaftermyfirstpregnancyandhadneverhadahealthconditioninmylife.I'vebeenlivingreally,largelyrecklesslyfromahealthperspective,literallyeatingMcDonald’s,drinkingRedBull,andeatingcandyeveryday,andneverexercised.Asaresident,neversleeping.Notonlyneversleeping,butthenIwouldgooutclubbingseveralnightsaweek.Neverevenathoughtthattherewouldbeacome-upx-rayortherewouldbeanyconsequencestothat.

[00:21:30] WhenIwasdiagnosed,Isawitasamassiveinconvenience,andIthoughtoftheideaofhavingtotakeaprescriptionfortherestofmylifewasjustatotalpainIdidn’twanttodealwith.IwenttoanaturopathnotbecauseIbelievedinalternativemedicineactuallyorevenhadanythingkindtosayaboutit,butbecauseIknewitwastheonlywayoutbecauseIknewwhatconventionalmedicinehadtoofferme,andIknewthatthatwasalifelongprescription.

[00:22:00] Itwasthroughsimplechangesgoing,glutenanddairy-free,takinganumberofantioxidants,vitamins,andminerals,forexample,andthenbeginningtorecommittoexercisethatIwatchedmynumbersgofromthehigh2000sandturningtheantibodiestothenormalrangeinaperiodofmonths.IwatchedmyTSHgofrom20tonormalinthatsametimeframe.

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AlotofredflagswereraisedformeandIsaid,“Holdonaminute.IneverlearnedthatfoodhadanythingtodowithmedicineandIneverlearnedthatyoucouldputachronicautoimmunediseaseintoremission,thatthatwasevenpossible.”Itwasveryinvigoratingforme.Itreallyignitedinmeafiretolearn.IhitthebooksandIbecamereallyinterestedinfunctionalmedicine.

Dr.AmyMyers:[00:23:00]

Atthetime,whenIwasgoingthroughmyautoimmunity,Ididn’tknowaboutfunctionalmedicine.Iwentthroughconventionaltreatment.IhadGraves’diseasewhichisanoveractivethyroid,anautoimmunediseaseofmythyroid.Verylongstoryshort,afterbeingontoxicmedicationthatnearlycausedmylivertofail,andthenultimatelyhavingmythyroidablatedwithIodine131,Inolongerhaveathyroid.It’sreallymymissionandmypassiontohelppeopletoneverhavetobeinmyboat.


Dr.PeterOsborne:[00:23:30][00:24:00]

Ihadagentlemanearlierthathadbeento60,sixzero,60differentdermatologists.Hehadsucharareformofautoimmuneskinrashthatoneofthedermatologistsinvitedhimtoaconferenceandaskedhimifhewouldsitin.Hesatinforfourhours.Allthedermatologistsatthisconferencecameinandwerelookingathimtryingtofigureoutwhathehad.Doyouknowwhathehad?Hehadglutensensitivityanditwastriggeringanautoimmuneresponse.Itwascomingoutinhisskin.Wewereabletogetridofthatrashthat60doctors,60,couldn’tfigureout.Wewereabletogetridofitinlessthansixmonths.That’sthepoweroffood.That’sthepowerofdietchange.That’sthepowerofnutrition.That’swhyIwishmoredoctorswouldstepin.

JonathanOtto: Allthedoctorsarelookinginthewrongplace?AsintheywerelookingfortheanswerbutIwouldconsiderthatprobablyit’spossiblethatnotasingleoneofthemevenassesseddietwasbeingthecausefortheskinreaction.

[00:24:30]Dr.PeterOsborne:[00:25:00]

Notevenathought.Theclosestthatoneevencametotheproperdiagnosis,oneofthedoctorsthoughtitmightbeaformaldehydeallergywhich,atleast,hewasthinkingallergybutitwasn’t.Nutritionissofundamental.Whenwelooktoseek,likewhatthesedoctorsweredoing,theywerelookingataskinandtheyweretryingtogiveitaname.That’sthewayitisinmedicine.Somanydoctorsaresohell-bentontryingtogivethingsnamesandclassificationsbuttheyforgettotreatthepatient.

Dr.O'Bryan: Isitsurprisingtoyouthatthethirdleadingcauseofdeathinthiscountryismedicalerrorsorgeneticdiseases?Thinkaboutalltheadvancementswe’vemadeasacivilization.Hasn’ttherebeensomuchwithourhealthcareinourmodernworldthathasimproved?Absolutely.

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Myfirstgranddaughterwasbornthislastsummer,andshewasbornsevenweekspremature.ShewasinNorthwestern’sneonatalintensivecarefortwomonths.ThankGodforthetechnologywe’vegottoday.Shewouldn’thavemadeitormyquestion,whatifshewouldhavemadeitifwedidn’thavethesophisticationandthetechnologythatwehave?Itwasmarvelous.IwassoimpressedwithwhatIsawthere.Now,she’shealthyandvibrant.Ijustgotatexttodaythatshelaughedforthefirsttimetodaywhichisreallybigstepforfirstparentsandfirstgrandparents.

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Howcanwebesoaridonthebiggestkiller?Whyisitthatwearetakingstepsbackwards?Asyoucontinuetolearninthisseries,youcanworkouthowyoucanswimagainstthetideandnotallowanyofthesedrasticstatisticsinvolveyouoryourfamily.Youcancontrolyourowndestiny.What’stheanswertothelackofhealthwe’regettingwiththemodernhealthcaresystem?Ifyouaresufferingwiththeconditionthatyouknowisduetonutritionaldeficienciesorharmfuldietarytriggers,howareyougoingtoputyourtrustinahealthcarepractitionerthathasatotaloffourtoeighthoursofnutritionaltraininginalloftheircoursework?Whatifyousufferedtraumaandyou'retryingtoworkouthowtoreversetheimpactsofthatanditsdetrimenttoyourhealth,wheredoyouturnto?


[00:27:00]

Thetruthisyouneedacrediblesolutionthathasthebestofwhatmodernmedicineofferswithathoroughknowledgeofthealternativeprotocolsthatyoumayjustreallyneed.Isfunctionalmedicinetheanswer?

Dr.PatrickHanaway:[00:27:30]

Autoimmunity,autoimmunedisease,thisspectrumthatwehavethatisaroundthisreactionthatwehavetowardsourselfandauto-inflammationwherethereisaninflammatoryprocessthat’sarising.Weseethiswithinatriadofthebalanceofwhat’shappeningwithenvironmentalexposure,ourgeneticpredisposition,intestinalpermeability,andtheinflammatoryupregulationthatwetendtohaveinourbodiesbecauseofourdietsandtoxinexposure,andthemanydifferentthingsthataregoingon.Theseleadtotheimmunesystembeingactivatedinawaythatisdysfunction.Itisoutofbalanceandendsupattackingpartofus.

[00:28:00]

Dependinguponourgeneticpredispositions,differenttissuesmaybeattacked.Differentsymptomsmayoccur.Symptomsmaychangeinindividualsovertimedependinguponwhattheexposuresare.Weseethisprocessofautoimmunityhavingadetrimentaleffect.Wegetcaughtupinnamingallthewaysinwhichitshowssymptomsanddisease,butreally,it’sahugeumbrellaofmany,manydifferentkindsofdiseases.

Functionalmedicinemakesadifferencebecauseitdoesn’tfocusonthedisease.Itfocusesandsays,“Why?What’sunderthat?What’stherootcause?”andhowdowebegintomakechangesinthat.

[00:28:30]IzabellaWentz,PharmD:

Ithinkthere’safundamentallivecellapproachthateverybodyneedstolookatwhenevertheyhadanautoimmuneconditionwhetherthat’sHashimoto’s,whetherthat’smultiplesclerosis,orrheumatoidarthritis,andthat’slookingattherootcauses.Whatarethetriggers?Whatarethepredispositions?Whatarethehabitsinmylifethatareleadingmetomanifestthiscondition?

Dr.MarkHyman:[00:29:00]

It’sawholehostoffactorsthatinteractswiththeirgeneticsdependingonourenvironment,ourgenesthattriggerourparticularproblem.There’svariabilityinthepopulationsothatthesameinsultscancausemanydifferentautoimmunediseases.Thereareonlythreemaintriggersforautoimmunediseasewithacoupleofadd-ons.Dietandstressalwaysinfluenceeverydiseasebutthemainthreetriggersareallergens,microbes,andtoxins.

[00:29:30]

Asfunctionalmedicinepractitioners,ourexpertiseisbeingabletodrilldownintoeachoftheseareasanddiscoverinanyparticularpersonwhat’sdrivingthatproblem.Youcanhavetenpeoplewithaparticularautoimmunediseaselikerheumatoidarthritiswhichhavetendifferentcauses.

Dr.MarkMenolascino:

Thoseofuswhopracticefunctionalmedicinehaveaverydiverseclientbasethatcometoseeusbecausethey’vetraditionallybeenfailedbyallopathicmedicineorthey’venotgottenthereliefortheanswersthatthey'relookingfor.Idofeelthatinthatpatientpopulationthatyourpredictivevalueofbeingapositiveautoimmune


issueisveryhigh,muchhigherthanwhataprimarycaredoctorwouldsayyes.

[00:30:00] Yourpointoftheseissuesbeingmanifestedbeforewedevelopacodeinesystemtolabeltothem.Agreatexampleisrheumatoidarthritis.Beforeyouhavejointchangesseenonx-ray,there’sabloodtestcalledtheCCPantibodythat’spositivefiveyearsbeforethere’saclinicalmanifestation.Oursensingmechanisms,ourtestingstrategiesarecurrentlyevolvingtothepointwherewecannowfindtheseearlysignsofautoimmunity.

[00:30:30] Ifeelthatwe’llhavepanelsthatincorporatecytokinesorinflammatorymarkersthataregoingtoshowusthisimbalancewaybeforetheclinicalconditionmanifests.Ifwecancatchitinthatwindowanddevelopaplanofindividualized,personalizedtherapy,wemaybeabletogetitsoitdoesn’tmanifestintoafull-blownautoimmunedisease.That’stheexcitingthingaboutwhatwe’redoingrightnowinfunctionalmedicine.


Yeah,becausealotofpeoplewillsay,“MymotherhasHashimoto’s.Sheisonthyroidreplacement.Myoldersisteris.Myauntswere.Iamjustgoingtogetit.”Ifyoudowhattheydid,youprobablywillbecauseyouprobablyhavethegeneticpredisposition.YoumighthavethatHLApatternorwhatever.Inyourimmunesystem,there’swholearraysofpredictiveantibodytestingthatwecando.

[00:31:30]

They'reusedinconventionalmedicinebuthere’showthey'reused.WewaituntilsomeonedevelopsalltheclinicalsignsandsymptomsofautoimmunediseaseX,andthenwesay,“Itlookslikeyouhavelupus,”or“Itlookslikeyouhaverheumatoidarthritisfromthejointdysfunctionandtheanatomicalarrangementandeverythingelse.Wehavetheseinflammatorymarkershigh.”We’regoingtoconfirmoursuspicionbydoingthisantibodytesting;wheninreality,themedicalresearchhasshownthattheseantibodiesareinthatperson’sblood5,10,15yearsbefore.

Dr.O'Bryan: Years.

[00:32:00]Dr.DavidBrady:

Yeah.Insteadofusingthemtoconfirmwhatyoualreadyknow,let’sturnthaton.It’shereandlet’susethemprophylacticallyandupstream.Let’stesttheminascreeningmethodologyjustlikeyouwouldgoandgetabloodchemistryoralipidpanel.

ProfessorYehudaShoenfeld:[00:32:30]

Theautoimmunediseaseislikeotherdiseases,arteriosclerosis,cancer.Theyaremultifactorial.Thereisnoonefactorwhichdeterminesifyouwouldgetadisease.Therefore,it’sthecombinationoffactorswhichjoinedtogetherinconcerttoinducethedisease.Therearemanyfactors.Therearegeneticfactors.Therearehormonalfactors.75%ofthediseasesprevailinfemale.Itmeanstheyhavesomething,atleast,afactorintheirbodywhichenhancetheimmunesystemsothattheywilldevelopautoimmunediseases.Thereareimmunodeficiencyfactors.


[00:33:00]

Therearealsotheenvironmentalfactors.Today,wetrytounderstandbettertheenvironmentalfactorandthecombinationandtheconcertofthesefactorswillleadtothedifferentdisease.Thisexplain(a),whyinthesamefamily,youhavepeoplewithdifferentautoimmunedisease;(b),whysomebodywhohasalreadyonediseasewilldevelopasecondautoimmunedisease.

Dr.JoePizzorno:[00:33:30]

Weseepatients,andallproblemsinallwalksoflife,andwelookatallthereasonswhytheymaynotbefunctioningproperly.Forexample,nutritionaldeficiency,atoxinoverload,musculoskeletalorneurologicalimbalance,thingslikethis.Wedoprimarycareandwealsohavereallygoodrelationswithotherhealthcareprofessionsiforwhenappropriate.Forexample,Igotbasictraininginassessmentofspinalventilationbutit’snotmyexpertise.Ihavechiropractorswhoaregoodfriendsofmine,andIsay,“Thisisclearlyinyourworld,youtakecareofitandsendbacktome,I’llworkonthediet.”

Dr.O'Bryan:[00:34:00]

IhavefriendswhereIlivewhoarenaturopathicphysicians,andwhensomeoneasksme,“WhoshouldIsee?”Isendthemtherefirstbecausemyexperienceofnaturopathsisthattheylookatthediet,theylookatnutrientinsufficiency,theylookatmusculoskeletal,andusuallyreferitoutbecausethat’snotarealstrengthforthembuttheyrecognizeit.Itsoundslikenaturopathphysiciansaremoreofaholistic,ifIcanusethatterm,orbigpictureviewtypeofpractitioner.

Dr.JoePizzorno:[00:34:30]

Inmanyways,we’reverysimilartothefamilydoctorofoldandthatwehavereallystrongrelationshipswithourpatientsandtheirfamilies,andwespendmoretimewiththembecausewe’reconcernedwhythey'resickandnotjustthattheyaresick.Yes,wediagnosedisease,andwedophysicalexam,wedolaboratorytests,andx-rays,allthosethings,anddiagnosewhat’sgoingon,butratherthansay,“Now,let’sgivethemadrug,”wesay,“No.Aretheresomenaturalapproacheswecantaketohelpthebodyhealitself.”

[00:35:00]

Ratherthanadrugtoturnoffthesymptom,andtheproblemwithmostofthedrugsistheyturnoffthesymptoms,they’lldealifpeoplearesick.Wewanttoknowwhythey'resick.Almostalways,it’seitheranutritionaldeficiencyor,unfortunatelynow,anenvironmentaltoxin.WehavebecomesotoxicinourmodernworldthatIamnotlecturingliterallyalloftheworldthattoxicityisnowtheprimarydriverofchronicdiseaseinalltheindustrializedworld.

Dr.O'Bryan:[00:35:30]

Haveyoueverbeentothedoctorandyoulistacoupleofthesymptomsyou'reexperiencing?Then,youtrytomakesureyoudon’tforgetanything.You'redesperatelytryingtogivethedoctoralltheinformationthey'reneedingandmakingyoufeelrushed,andsometimesmaybeevenlikeyou'rebeingherdedtoagenericsolution.Whataboutyouruniquehistory?Whataboutthingsthathavehappenedinyourpersonalexperience,perhapsinyourchildhood,thatcouldbethecauseorafactorforwhatyou'reexperiencing?They'recriticallyimportant.Whyhasfunctionalmedicineproventobesoeffective?What’stheunderlyingprincipleoffunctionalmedicine?Letmehelpyouunderstandthefoundational


conceptoffunctionalmedicine.Dr.O’Bryan What’sthetypicalpatientthatcomesintoseeyou?

[00:36:00]Dr.GabrielDeCarvalho

Theyhavemany,manycomplaintstogether.Theywanttoloseweight.Theyhavemigrainesorheadaches.Theyhaveallergieslikesinusitisrhinitis.Theyhavegutproblemslikeconstipation,bloating.Allthebodyisbeingattacked.Itlooksliketheirolderbodyisbeingattackedbysomethingtheydon’tknow.Theyhavenoideawhat’sgoingon.

Dr.O'Bryan: Howdoyoufindwhat’sgoingonforthem?

[00:36:30]Dr.GabrielCarvalho:

Imakeseveralquestionnairesandseveralbloodtestsaswellsowecanthenfigureitout.Ofcourse,wehavetomakemanyquestionsaboutwhattheyeat,theirdailyhabits,howmuchtheysleep,iftheyoccasion,howmuchhoursofworkduringtheday.Weputallthisinformationtogetherinthematrix.Then,wecanrealizewhat’sgoingon.Questionnaire,andbloodtests,andsaliva,andeverything,it’sveryimportantforputtingeverythingtogether.

[00:37:00]Dr.PriyaKumani:[00:37:30]

Functionalmedicinelooksverycomprehensivelyatthepatient’shistory.It’sratheralongquestionnairebutit’sverycomprehensive,anditlooksbothacrosssymptomsanddiagnoses,butalsoyourlifestyle,yourfamilyhistory,yourdiets.Extremelydetailedquestionsabouteverything.Thisentirestory,wealsohaveacoupleofsectionswhereweaskspecificstotimeline.Weaskquestionsaboutwhenpeoplehavethings.

[00:38:00]

Inmedicine,forinstance,peopleaskaboutwhathaveyouhadinthepastbutinaverygeneralway.There’sveryfewpeopleaskingyouspecifically,“Tellus,whichyeardidyouactuallyhavethis?”Wegetintothatkindofdetailsothatwecantakeallofthatinformationandplotitintoapatient’stimeline.It’sprettyremarkablewhathappens.

Dr.DavidJones:[00:38:30]

Becauseitturnsoutthereisaway.ThatcomesbacktothatgreatstatementthatwasmadebyPeabodyahundredyearsagoatHarvardatacommencementwhichthatpaper,it’sjustitcouldhavebeenwrittentodayandbejustasrelevant.Attheendofit,hesays,“Thesecrettothecareofthepatientistocareforthepatient.”Ifyoucarethepatient,youhavetoknowthepatient.Ifyoureallywanttocareforthepatientandyou'recommittedtothepatient,youhavetoreallyknowthepatient.

Dr.TomO’Bryan: Inyournewpatients,howmuchtimemightyouspendwiththenewpatientbeforeyoucomeupwithaconclusionastowhatprotocolstorecommendtothem.

[00:39:00]Dr.GabrielCarvalho:

Usually,it’sinthesecondvisit.Inthefirstvisit,Ihaveanhour,anhour-and-a-half.

Dr.O'Bryan: Youspendanhourtoanhour-and-a-halfwiththepatientthefirstpatient?


Dr.GabrielCarvalho:

Yeah,exactly.

Dr.O'Bryan:

Actually,that’swhatittakesandthat’swhatfunctionalmedicineisallaboutisgettingthatbigpicture,isn’tit?

Dr.GabrielCarvalho:[00:39:30]

Yeah,itis.Forsure.Itisimpossibletodoitinhalf-an-hour.Atleastanhour.Yeah,anhourtoanhour-and-15usuallyisfine.IfinishmyanamnesisusuallyinthesecondvisitwhenIhavealreadyorderedandIamseeingtheresultsofthebloodtestandeverything.Iputeverythingtogether,thequestions,thequestionnaires,andthelabtests.EverythingtogetherandIcan,then,seethebigpicture.

Dr.PriyaKumani: Inthepast,functionalmedicinedoctorswouldcreateatimelineonpaperwiththeirhandswhichisgreat.It’sawonderfulwaytodialoguewiththepatientandcaptureinformationandthen,noteitdownonthetimeline.

[00:40:00]Dr.O'Bryan:

Iwoulddothat,anditwasalwaysamessbecausepatientsremembersomethingthat,“Yeah,bytheway,backthere…”Now,IamwritingontoporI'mtryingtoputarrowsinthere.

Dr.PriyaKumani: Also,there’saninherentbiasbecausewhatwe’redoingiswe’refilteringtheinformation.Weonlyputdownthingsthatwethinkareimportantasapractitioner,right?

Dr.O'Bryan: You’reright.You'reright.

Dr.PriyaKumani:[00:40:30][00:41:00]

Here,wetakeeverythingthatthepatienthassaidandisrelevant.Actually,eventheprocessof…I'veheardthisfrommanypatientswhosaidthattheprocessofgoingthroughthatsystematically,issue-by-issue,makesthemthinkanditalsohelpsthemprepareforthevisit.Anyway,wetakethatinformation.Now,there’sapatternmaybethatshowsupwhichyouwouldneverhavegottenifyouwerejustwritingitonpaper.It’sagreatwaybecausethetoolsarevery,verygraphicandvisual.Youcannowsitwiththepatientanddialogueaboutthat.

[00:41:30]

Wehearconstantly,peoplecomeovertouswhenwe’reatconferencesandstuffandsay,“IhavethisgreatstorywhereIwasshowingthispatientthistimeline.Allofasudden,theylookonthetimelineandsaid,‘Oh,that’swhere…’andsometimes,somethingverysignificanthappened.”Including,I’veheardoverandoverfrompractitionersthatincidencesoftrauma,orabuse,orthingsthatarehighlysensitivesometimesdon’tcomeupfortwo,three,four,fivevisitsbecauseit’sjust…

Dr.O'Bryan: It’sjustverydeepinside.


Dr.PriyaKumani:[00:42:00][00:42:30]

Exactly,butthere’ssomethingaboutseeingthatvisual.Allthesudden,forittotriggerinthepatient’sheadthatlookatallthesesymptomsthathavehappened,somethinghappenedhere.Forthemtobegintoassociatebecausewethink,“Oh,Ihadthatbutit’snotaffectedme.It’snotaffectedmylife.”Now,ifyou'reseeingthevisualofit,andyou'reabletolookatit,andthenitstartstohithomethatmaybetherewassomeimplicationtowhathappened.Itbecomesmoreconscious.Then,they'reabletobringitupanddialogueaboutit.It’shelpingthatstorygetclearerearlierintheprocess.

Dr.O'Bryan: Weseethatsomanydifferentconditionsthatcomeintoourofficewhenwelook,theimmunesystemhasgottenactivated,andthewaytoaddresstheimmunesystemisnottoquietitdownbutrathertoreducetheneedforitsactivation.

Dr.DavidBrady: Right.That’sright.

Dr.O'Bryan: That’sthewholepremiseoffunctionalmedicine.


Itis.You'reright.Alloftheclassicagentsthatareusedinthepharmaceuticalrealmfordealingwithautoimmunediseaseareeithertosquashtheinflammatory,theautoimmuneresponse,ortogetintoactualobliterationofalmostallimmunitywithresponsemodifiers,andbiologics,andthingslikethat.Theycanbeveryeffectivefromthesymptommanagementstandpoint.There’snodoubt.

[00:43:30][00:44:00]

Somepeople,ifthey’rereallyinbadshapeandendstage,thatmaybeexactlywhattheyneedaspartoftheoveralltreatmentplan,butunderstandablypatientswhogetofferedthatastheonlyoption,andparticularlyifit’searlieronintheirdiseasecourse,nowadaystheygorighttotheinternet,andtheystartlookingupwhatarethesemedications,whataretheyallabout,andwhatarethesideeffects.Whentheyseelittlenastythings,littleinconvenientsideeffects,thingslikeleukemiaandlymphoma,theyunderstandablygetalittlebitagitatedaboutgettingonthose.They’relookingforotheroptions.Ithinkthefunctionalmedicineparadigmoffersthemexactlythat.

Dr.O'Bryan:[00:44:30]

Here’sadrug.Thisistheansweryou’vebeenlookingfor.We’retoldtakeitfortherestofyourlife.We’renottoldwhereistheproblemcomingfrom.Thisisnotthesolution.Thisisjusthelpingusfunctionalittlebitbetterbutwhereisitcomingfrom?Inthisdocuseries,youwilllearnwherethisiscomingfrom.Youapplytheprinciplesyoulearnhereandtheresultisyoustartfeelingbetter.Yourequirelessandlessofthismedication.Yougobacktothedoctorthatprescribedyouthismedicationandsay,“WillyouworkwithmeandhelpmetransitionoffifIdon’tneedthis.”Then,youcangetridofit.

JonathanOtto: Doyoubelievethatthere’sevidencesthatthere’ssomethingwrongfundamentallywiththesystempotentiallyfromamonetarystandpoint?


[00:45:00]Dr.PeterOsborne:[00:45:30]

Ibelieveitbutit’snotabeliefjusttobelieve.It’sthetruth.Let’sjustanalyzewhatweknow,whatwe’velearned.TherewasastudythatcameoutjustacoupleofmonthsagoontheBritishMedicalJournal.Itwasareallygoodstudy.Itwasananalysisofthetopcausesofdeath.Whatthestudycametotheconclusionofisthatheartdiseaseandcancerwerethenumberoneandtwokillersbutthethirdleadingcauseofdeathwasmedicalerror.Now,whatdoesthatmean?Somebodywillsay,“Theyoverdosedonthedrug,”or,“No,theydiedinsurgery.”No,medicalerrormeanstheproperuseofprescriptionmedication.

[00:46:00]

Ifwelookattheleadingcausesofdeath,andwesay,“Okay,howdowetreatthisthings?Thesystemthatwehave.Whatdoweusetotreattheseleadingcausesofdeath?”Weusemedicinebutmedicineisthethirdleadingcauseofdeath.Doesthatmakesensetoyou?That’sdata.Ididn’tmakethatup.That’srawempiricaldata.Whatittellsmeiswe’redoingthewrongthing.Maybewe’renotdoingthewrongthing100%ofthetime.Idon’tthinkdoctorsareouttheremal-intentioned.Idon’tthinktherearedoctorsouttheresaying,“I’mgoingtoputyouonthisdrugandwe’regoingtohurtyouonpurpose.”

[00:46:30]

No,andlikelythecasethatyouget,theywerelookingfortheanswer.Ifindthatquiteacompassionatethingtodolikeatmostbeforetheysendhimaway.Itsoundslikealotofthosedoctorswerevolunteeringtheirtimejusttolookatthem.Yeah,butit’sstillindarkwhenitgetstothesystemmorethananything.

[00:47:00]

Absolutely.That’swhatthesystempromotes.Thesystempromotesthatdrugsaretheonlythingthatcantreat,curedisease.Aperfectexample,lookatabottleofsupplements.Onthebottomofit,it’sgoingtosay“FDAdisclaimer.Thisproductwasnotintendedtotreat,cure,diagnoseanydisease.”Whydoesithavetosaythat?Becausemedicineensuresthatnobodyelsehasathoughtprocess.Didanythingotherthandrugscantreat,cure,diagnosedisease?

JonathanOtto: That’sfallacy.

Dr.PeterOsborne:

It’salawanditisfallacybecausewe’vegotnaturalmedicinesthatdowonderfulthingsthatareequallyandsometimesmoreeffectivethanprescriptivedrugs.

JonathanOtto: Noquestion.

Dr.PeterOsborne:[00:47:30]

Yeah,noquestionaboutit.Thereareplentyofotherculturesthatdon’tevendiveintothedrugaspectofthetreatment,andonlyusemedicinals,andherbals,andbotanicals.They’rejustaswellandactuallydobetter.America’shealthcaresystem,IthinklasttimeIlookedatthenumbers,itwasranked37whichisofindustrializednations.That’sverypoorconsideringwespendmorethananyothernationintheworldondrugresearch,andondruguses,andonmedicalcare.Then,wejustsubsidizethiscare.

Now,wesaid,“Let’staketaxpayerdollarsandgiveawaythiscarethatdoesn’tworkbecausethesystemisbroken.Let’sgiveawaythisbrokencareandthis


[00:48:00] brokensystemtopeopleforfree.”NotthatIdon’tthinkpeopleshouldhaveaccesstosomekindofcare.Ijustdon’tthinkthattaxpayerdollarsshouldfundasystemthatdoesn’twork.It’sprovenitselftobeineffective.

[00:48:30]

Youthinkalotfromabusinessperspective.I’mabusinessman.I’malsoadoctorandI’malsocompassionate.Ithinktherearealotofpeopleouttherelikethat.Fromabusinessperspective,medicineistheonlybusinessthatcontinuoustogrowatanexponentialratedespitefailingmiserablyitscostumer.Whatotherbusinesscanyouthinkofotherthangovernmentthathasthattrackrecord?

JonathanOtto:[00:49:00]

WithSynthroidbeingthenumberonedrugfor2013and’14,isshowingyouthatthatistheonlymethodforthemajorityofpeoplefortreatingthyroiddisease.Forexample,someofmycancerpeoplearegettingmoreandmoreaware,“Hey,Ihavesomeoptionshere,”butwithalotoftheautoimmunediseases,theyliterallyjugmeiftheyhaveanyoptionintheworldexceptfordrugX.You’renotcoolwiththat.

AndreaNakayama:[00:49:30]

Iamnotcoolwiththat.Ilivedinabubblewherethepopulationthatcomestomewantstotakeownership.Thereisareallybroadpopulationthat’sjustbuyingintothedrugasthesolutionandIamnotcoolwiththat.Alotofthedrugs,notonlyaretheynotactuallyaddressingtherootcause,theycouldbedoingfurtherdamage,especiallywhenwelookatthefactthattherearegeneticunderpinningstoautoimmunity,thewaythatthatpersonprocessesthedrugsmaynotbewhattheliteraturesaysit’ssupposedtobe.I’veseenthisinanumberofmyclientswherethey’reactuallynotabletoprocessthedrugsandit’sdoingmoreharmthangood.

JonathanOtto: Wow.Whatistheansweronthat?

[00:50:00]AndreaNakayama:

It’smultifactorial.Ithinkthattheanswerisreallyunderstandingwhat’strueforourselves,understandingtherootsofourownautoimmuneexpression,andbeingabletomitigatethatbytakingownership,reallyunderstandingwhat’strueforus,whatmakesusfeelbetterorworse,andassemblingtheteamthatreallyseesthewholeindividualandwhoweare,andisabletoworkthroughthatlens.

Dr.StevenMasley:[00:50:30]

Toooften,withthesepeopleondrugs,wemaketheirmarkerslookbetter,theirmajorhealthmarkers,butwehaven’tfoundtheunderlyingcauseandwehaven’tfixedit.We’vedonethemadisservice.WhenIputsomeoneonmedication,IalwaysfeellikeIfailedthem.It’snotthatI’manti-med.ThatmeansIdidn’tfindtheunderlyingcauseandthereprobablywasonethatwouldhaveactuallybeenthetruesolutionandwouldhavedoneitwithoutmedication.

Dr.O'Bryan: That’sreallyabumperstickerforyourpractice,“IfIhavetoputsomebodyonmedication,IfeelIfailed.”

Dr.StevenMasley:

Ihave.

Dr.O'Bryan: That’sreallyquiteprofound.


Dr.StevenMasley:

Ididn’tfiguresomethingout.

Dr.O'Bryan:[00:51:00]

Yes,andyouneedsomehelpinthemeantimeforthatpersontofeelbetterandfunction.I'veassumeyoujustkeepdivinginandlookingdeeper.


Ijustkeepworkingonit.Igo,asIstartonamed,it’slike,“Hopefully,Icanstopthisinthreetosixmonths.We’llfigureitoutandyouwon’tneeditanymore.”Ithinkalotoftimesthey’vebeentoallthesedoctors,they’vebeentoallthesespecialists,theyputthemondrugafterdrugwhichmadethemfeelworse,andthey’rebecominghopeless.Ithinkthat’sareallyimportantthingtogivepeopletheirhopebackwhetherit’sheartdiseaseorcognitivedysfunction,ordepression¸orjustpainthatmostpeoplecanreallytransformthatbyfollowingaprogramthatisintended,thattheirgeneshavebeenwaitingforthemtodoallalong.


OneofthebiggestthingsIhearfrompatientswhoarebraveenoughtocometome,becauseittakesalotofcouragetosay,“Idon’tbelievethatotherdoctororthoseothertendoctorswhoaresayingthatI’mjustgettingolder.”That’soneofthebigmythsandthebigliesisthatdiseaseisanaturalprogressionofaging.Wetrytocreatediseasesoutofnaturalthingsinlife.Whenawomangoesthroughmenopause,wetrytocreateadiseaseoutofthat,andsaythatthatsomehownowitneedstobemedicated.Whenamangoesthroughsimilarchanges,hormonalchangesashegetsolder,wenowcallthatadiseaseandthenwesay,“Weneedtomedicatethat.”

JonathanOtto: That’sagreatideaifyouwanttomakemoneyoutofit.

[00:52:30]Dr.PeterOsborne:

It’saperfectideaifyouwanttomakemoney.Iusetheworddiseasifying.Wediseasifiednormalprocessesandwe’vejustifiedthathumanshouldbefunctioningat100%allthetime.ifthey’re,notwe’regoingtocallwhateverthatisadiseaseandcreatesomekindoftreatment.

[00:53:00]

Forexample,depression.Apersoncanhavedepressionifthey’resad.There’snothingwrongwiththestateofbeingsadandgoingthroughaperiodofdepression.That’spartoflife’sexperiencebutalotofdoctors,ifapersongoesinandthey'redepressed,maybebecausetheylostaloveone,maybebecausethey’regoingthroughareallyhardtime,depressionisanimportantemotionthattheyneedtogothroughortheyneedtoworkthatoutintheirownmind,butthedoctorissaying,“No,youhavethisdepression.Here,let’scoveritup.”Let’scallitadiseaseinsteadofthestateofbeinghuman.

We’vedehumanizedinmedicineandwe’veopenedthedoorthatanythingabnormalatanytimeisgoingtobeconsideredadiseasethatneedstobetreated.Bytheway,Ihavethattreatmentinmycloset,andwe’regoingtogivethattoyou.Ithinkthat’sahorribleapproach.


[00:53:30]Dr.DavidJones:[00:54:00]

Icameoutofmedicalschoolwiththisillusion.MedicalschoolisnotwhatIexpectedittobe.Ithoughtweweregoingtostudyhumanphysiology.Then,weweregoingtostudyhowpeoplemakedecisions.We’regoingtoputthosetwothingstogether.Then,Iwouldbeabletohelppeople.Itreallywasn’taboutthat.Itwasaboutacertainheuristicofyouevaluatingapatientnotasawholeperson.You’reevaluatingapatientasasystemoforgans,andyouaskquestionstotrytosingledownandfocusdownonwhichorgansystemishavingthemosttrouble.Then,youlookinthedrugbooktofindout…First,youmadeadiagnosisofwhatpartofthatorgansystem,whatdoesitfeellikeintermsofadiagnosis,andthenwhatdrugscanbeused.

[00:54:30] It’sactuallyaparadigmthatIwishitwerethatsimplebecauseit’seasiertodo.Ifinishedmyeducation,wentintopractice.ItwasreallyonlyabouttwoyearsonthepracticethatIsatattheendofthedaylookingatthelistofpatients,andIthought,“Abouthalfofthesepeoplehavebeenbetteroffiftheyhadn’tcomebecausethey’reallondrugsthatarecausingallkindsofmischiefintheirlife.”Then,IlookatthelistforwhowascominginthenextdayandIsaid,“Idon’tevenknowI'mactuallytocallandsay,‘I’monlygoingtodomischiefinyourlife.Whydon’tyounotcome?Ididn’tknowenough.’”

[00:55:00]Dr.AmyMyers:

Idon’tthinkyoucanblamethephysicians.MaybemedicalschoolandhowdoctorsaretrainedbutIdothinkthevastmajorityofdoctorsgointomedicinewiththeideathattheywanttohelppeople.They’retaughthowtohelppeopleinacertainkindofwaywhichforsomepeople,itdoeswork,butformanypeople,itdoesn’twork.

[00:55:30][00:56:00]

IwasanemergencymedicinephysicianbeforeIbecameafunctionalmedicinephysician.Idothinkthatconventionalmedicinedoesareallygreatjobatemergencycare.IwasatraumaERphysician,andifIgotshotorwasinacaraccident,Iwouldwanttogotothetraumacenter.IfIhadcancerorautoimmunity,Ididn’tknowaboutitatthetimethatIwasgoingthroughmyautoimmunecondition.Ididn’tknowaboutfunctionalmedicinebutclearly,,ifsomethingwouldhavehappenedtomeinthefuture,it’swhatIwouldturnto.It’showIlivedmylifeeveryday.It’swhatIhopeotherswillturntooaswellbecauseitdoesgiveyouhope.

SayerJi: Chemotherapyisusedinthecaseofautoimmunitybecausetheverybrutishpremisesyouwanttodestroytheimmunesystem.They’reusingsomeoftheverysameagents.Then,ofcourse,cancer,we’reusing,asweknow,conventionalwarfarechemoandradiation.It’slikeaninsanemodel.Notonlydoyoufeelbetrayed.Youhavethiscondition.Yourbodyisattackingyourself.

[00:56:30]

Now,theconventionalmedicalsystemissaying,“We’vegottoblastthisenemywithin.”Then,literally,thecollateraldamageislikeoffthechain,yes,orthemetaphoricissoprofound,thepoetry,becausethisisveryinstitutionalequivalentoftheimmunesystem.Theconventionalmedicalsystemissupposedtohelptakecareofitsdamagedpopulation,andit’sfeeding,andprofiting,andamplifyingthe


[00:57:00] damage.It’salmostlikeareiterationoftheveryhorrorofbetrayal.Yeah,you’reright.Thebetrayalthemefromtheconditionallthewayuptothemisguidedtreatmentreally,it’spowerful.

[00:57:30]

Hyperthyroidismisanexamplebecausethat’swhenautoantibodieshaveformedagainstthethyroid.Whatdoestheconventionalmedicalsystemdo?Theyactuallyattempttotakethethyroidout.Theyevendothisradiooblation.ThetakeradioactiveIodine131whichisreleasedinnucleardisasters.It’swhyeveryonewanttostockupwithpotassiumiodidewherethere’sanuclearthreatbecausethiselementiswhatdestroysthethyroid.

[00:58:00]

Theyfindthattheimmunesystemisattackingthethyroid.Insteadoftryingtofindtherootcauseandremoveit,theydecidethey’regoingtotaketheverythingthatcankillyourthyroid,blastit,andsurgicallyremoveit,andthenreplacethethyroidhormonewithsyntheticthyroxinorSynthroidwhichhasacompletelydifferenttertiaryconfirmation.Actually,theprimarysequenceisdifferentthanhumanthyroxin.Theypushitasifitisjustasgood,ifnotbetter.Inotherwords,it’slikethiscascadeofbetrayal.People’sthyroidsareliterallyremovedwhenalltheyhadtodoisremovegluten,forexample,oraddresssometypeoftoxicandexposure.

[00:58:30]Dr.PeterOsborne:

Ithinkyouneedabusinessthatmakes$100billionannuallythatfailstoleadtheircustomerstosomeformofmeaningfulresolutionistore-evaluatetheirbusinessmodel.

JonathanOtto: I’dsaythattheyhave.Lookattheseexamplesofallthesepeoplethatarebetter.


Iagreewiththat.Yousaylookatthepeoplewhosesymptomsarereducedbutwhathappenswiththeirlifespan?Theaverageautoimmunepatientwillhavealifespanonaverageabout26yearslessthantheircounterpartwithoutautoimmunedisease.Youdidn’treallyservethem.Youservedthembybeingcompassionatetowardtheirpainortowardtheirsymptom,andthat’swhereyoumadeyourmoney.Youmadeyourmoneytomasktheirbody’salarms.

[00:59:30]

Iagreewithyou.Itisabetrayal.Anyintelligentpersoncouldanalyzethisfromtheperspectivethatifweonlymasksymptoms,andintheprocessofmaskingsymptoms,wecreatenewdiseasewiththedrugsweusetotreatthosesymptoms.Autoimmuneisnotoriousforthis.Lookatthedrugsused,theimmune-suppressingdrugsthatareusedtotreatlupus,andrheumatoidarthritis,andpsoriaticarthritis,itcausecancer.It’sveryclearonthewarninglabel.Veryclear,theycausecancer.Theyshutdowntheimmunesystem.

JonathanOtto: They'renon-transmissions?


Yes.Isthatasolution?Isthatsomethingyouwanttogivea$100billionayeartoasthesolutionwhentheoutcomesarepoor?Ithinkweneedtolookatdifferentoutcomes.Theoutcomesare,“Yeah,yourpainisreduced.Yes,yourrashgoesaway.”Thosearen’toutcomesofresolution.Thoseareoutcomesofsymptomatic


reduction.Idon’tthinkwecanbasethemodeloftreatment,again,onshuttingdownthebody’sabilitytowarnus.

Dr.SaraGottfried: Wehaveanoutdatedclinicalmodel.It’sreallybasedon,“Youhaveadisease,here’sapill.Youhaveacold,takeanantibiotic.”Ithasnotserveduswell.Itgotustothebottomofthelist.

[01:00:30]Dr.O'Bryan:

Lookattheresult.That’sright.Lookattheresult.

Dr.SaraGottfried:[01:01:00]

Doingarootcauseanalysis,lookingatasystems-basedapproachtothebody,lookingat,“Okay,whyareyourundown?YougoexposedtoaviruswhenyouflewtoEuropelastweek.Now,you’resickwiththevirus.”Justtryingtounderstandwhatarethelevershere.Howmuchstressdoyouhaveinyourlife?Howareyoudancingwiththatstress?Howmuchsleepareyougetting?Weknowthatyouneed7to8.5hoursatnighttoreallyfunctionthebest.

Dr.O'Bryan: Iwouldsay,whatarethelimitsthatyou’reunwillingtoacknowledge?Ifyoulookatitclearly,yousay,“IpushedtheboundariesalittletoofarherethatI'vecrossedmylimit.”Acknowledgethatwe’rehuman,wehavelimits,andwehavetotakecareofthesebodiessotheycancontinuetofunctionforus.


Ifeellikeyou’relookingspecificallyatmewiththatonebecauseI’marecoveringoverachieverandIdon’twanttohavelimits.It’sahumancondition.

Dr.O'Bryan: Itis.Itis.

Dr.SaraGottfried: Wehavetogetrigorouslyhonestaboutthis.It’ssuperimportant.Whetheryou’retryingtogetpregnant,oryou’refacingperimenopause,oryougotyourthirdcoldinthewinter,it’simportanttofacethese.

Dr.O'Bryan: Oneofmypersonalgoals,andwhetherthisresonatesforothersortheyhavetheirown,inthesamecategory,IwanttomakesureIcantakemygrandkidshikingintheAlpsinmy80s.

[01:02:00]Dr.SaraGottfried:

Ilikethat.

Dr.O'Bryan: InordertodothatiswhatIdonowandinthemiddleagesthatdeterminesthat.Forallofus,wehavetotakeastepbackfromhowwefeelanddosomeindependentevaluation,biomarkers,ifyouwill,astohowourbodyisfunctioning.


Yeah,thisissuchanimportantpoint.Itgetsbacktoathemethatwe'vehad,thefreelineforaconversationwhichisyouwantyoungageandmiddleagetolastaslongaspossible.It’snotnecessarilylongevitythatwewant,it’shealthspan.YouhikingintheAlpswithyourgrandchildren,thatisabouthealthspan.It’saboutfeelingfantastic,notbeinginanursinghomeatage80withAlzheimer’sdiseaseor


[01:03:00]

withrheumatoidarthritis.Weknowthattheseconditionsarerecognizabledecadesbeforeyouhavesymptoms.Thekeyistobeproactive,tobepredictive,topersonalizethis,togetsuperhealthyasyoungaspossible.Then,maintainit.

Dr.DanKalish: It’sveryeasyforustomaskautoimmuneproblemswithmedicationsorwithnaturalsupplements.Inmyfirstfiveyearsofpractice,Iactuallythoughtmyjobwastogetgoodatsymptomaticcontrolsothatwithinafewweeks,thispersoncouldbeinlesspain.That’stheobviouscompassionatethingtodowhenyou’readoctorasyouwantthispersontofeelbetter.

[01:03:30]

Then,yourealizeasyearsgobythatwhenthosepatientscomebackyearslaterwithevenmorepainthattheyhadoriginallythatyou’veactuallyunderminedthehumanprocessbydenyingthemthefeedbackthatcomesfrommakinglifestylechangesfirst.Ireallyemphasizethis,thediet,thesleep,theexercise,themeditationastheinitialroundoftreatmentwhilewe’rerunninglabsandwhilewe’reanalyzingwhat’sactuallygoingonasanunderlyingcause.

[01:04:00]

WhatIfoundinthegroupofpatientsthatI’veworkedwithmorerecently,thelast15to20years,isthatwhentheyunderstandhowmuchfoodcanrelievetheirpain,howmuchisagoodnightsleepcanrelievetheirpain,thenthey'remotivatedtocontinuetherealtreatmentswhicharetheselifestylechanges.Theyunderstandthatthere’saveryrealtherapeuticimpactofsomethingassimpleassleepormeditationthatmightbeevenmorepowerfulthananyofthesupplementsordrugs.

Dr.KellyBrogan:[01:04:30][01:05:00]

That’sbeenmyobservationthatpeoplewhotaketheinvitationthatisembeddedinillness,andtheyacceptit,andtheyworkwithit,andtheyshifttheirbeliefsbecauseofit,theygoontolivereallyrich,fulfilling,expandedlives.Iwitnessthatthepeoplewhotreatdiseasesasjustanothermisfortune,andtheybegintoaccumulatealistofthediseasesthattheyaredealingwith,andthemedicationsthataccompanythem,I’mnotsurethat’sreallyalifetheyfeeltheywouldhavesignedupforifgiventhechoice.Then,they'rejustbasicallysurvivinguntiltheydie.Ithinkmostofushaveaninnatesensethatthat’snotallthereistothisexperience,thatthereismorethat’spossible.

Dr.O'Bryan: Iknowyou’veheardthehorrorstories,allthesufferingpeoplegothrough.You’veseenitwithyourlovedonesandfriends.Perhaps,you’veheardafewoftheturnaroundstories.That’swhywe’resharingthis.It’snotjusttoshockyou.It’stogiveyouthesolutionsyou’renotbeingtold.Letmetellyouaboutthehope.Arepeoplereallygettingbetter?Isittrulypossible?We’reabouttosharewithyousomeoftheamazingcasestudies.

[01:05:30]JamesMaskell:

IgotafriendwhoIwenttoschoolwith,andhegotcolitis,anddealtwithcolitis,wentdowntheregularroute.Suddenly,threefeetofhisgutwastakenout.He’dlostacertainpartofhisbody.ThisisafriendthatIwenttoschoolwithwhenIwassevenyearsold.Theplantherewasjustthere’snopreventiveaction.Suddenly,youhavecolitis,youhavethreefeetofyourgutout,andthen,now,Icontinueto


[01:06:00] seeonsocialmediathathe’sinandoutofhospitalstillhavingoperationseveryyear,hadproblemswithhavingafamily.

[01:06:30]

Iseethatcolitis,Iseedoctorsinfunctionalmedicineeverydayreversinginweeks,ifnotmonths.Thatisverystrikingexampleofwhyweneedmoreofthisanditkeepsmegoing.Personally,I’vehadmoreinteractionswithcancerandmentalillness,butatthesametime,it’sonlybecomingcleartowhatdegreeautoimmunediseaseplaysaroleinthosekindsofthingstoo.

Dr.GabrieldeCarvalho:[01:07:00]

Ihadapatientjustlastweekwithrheumatoidarthritiswhichstartedwithmeayearago.Shewastakingmanymedicines,andlotsofpain,noimprovementatall.Shewasinthehighestdosagepossible.Therewasnothingherdoctorcoulddoforherotherthanhewasalreadydoing.Then,shecametomyoffice.ItwasinJulylastyear.Westartedalltheprotocolwhichisanindividualizedprotocol.

[01:07:30]

Now,shecamebackeverymonthoreverytwomonths.Shewasbacktotheclinic.Then,Iaskedheratherlastvisit,“Howareyoufeeling?Whatwasyourimprovementduringthisyear?”Shealmostcried.Ithinkitwasthefirsttimeshewasnotwithherhusbandtogether.Shetoldme,“Myhusbandpraysforyoueverydaybecausehedoesn’thearmecomplaining,andmoaning,andcryingeverydaybecauseofthepain.”

Dr.DavidBrady:[01:08:00][01:08:30]

Ithinkit’sparticularlyproblematicandtraumaticforyoungerpeoplewhoareallofthesuddenfacingachronicdiseasediagnosis.Someoneintheirmidtolate20s,let’ssayafemale,allofasudden,wetellher,“Youhavethyroidissueandyouhaveautoimmunityagainstyourthyroid,”orayoungpersonwithrheumatoidarthritis,orI’vehadveryyoungpeoplewithreallybadpsoriasisorsomethinglikethat,they'releftinadaze,“Whyme?I’myoung.WhydoIhavetodealwiththiskindofproblem.Isn’tthisaproblemforoldpeople?Whywasitme.Isthismyfate?Thisismygenes.Ihavetodealwiththis.There’snothinggoodthat’sgoingtocomeofit.”

[01:09:00]

Ithinkit’sourjobashealthcareproviderstonotbecallustothat,andtoreallyunderstandthatabigpartofthetherapeuticinterventionweofferandthehealingprocessistoreally…We’renotsomeomnipotenthealerswherewejustmakeeverythingbetter.We’rereallyonajourneywiththem.We’retheirhealthcoach.

[01:09:30]

That’swhyIlikethatmodelofhealthcoaching,healthcoaches,becauseitreallyautomaticallyimpliesthatexpectationthatthepatientisgoingtobeactivelyinvolved.It’snotjustgoingtobesomedoctorgivingthemsomemagicpillorsomemagicfixbecausethatrarelyisthecaseparticularlyinchronicdisease.Thepatienthastoengagewithyouintheirrecoveryemotionally,behaviorally,sometimesspiritually.Youhavetowalkthemaroundtothat.Theydon’tjustautomaticallygetthere.Particularly,iftheyarefairlyyoung,they'renotatthepointofevenframingupthatway.Maturity,youtendtothinkthatwayalittlebitmoreasyougetolder.


[01:10:00][01:10:30]

Sometimes,it’sjustreassuringthem,“Listen,you’renotaloneinthis.Firstofall,thisisveryprevalent.It’sbecomingmoreandmoreprevalent.Yeah,youmayhavethisinyourfamilyhistory.Maybeallyourolderrelativesandfamilymembershavethisbecausetheydidn’tknowanybetter.Theydidn’tknowthethingsthattheycandotochangetheoutcome.Now,wedoknow.We’llworkwithyou.Yeah,youmighthavetochangealittlebitaboutthewayyoueat,abouttheamountofstressyou’reunder,aboutvariousthingsinyourlife,buttheseareallgoodthingsanyway.You’lllearnhowtodothis.You’lllearnhowtoworkthisintoyourlife.You’llbehealthierforitinthelongrunwaybeyondjustnothavingHashimoto’sthyroiditisorwaybeyondhavingroomtowardarthritis.Thesearejustgoodhealthpracticesforalongvibrantlife.”

[01:11:00]

Themajorityofthemarewillingtogetonboardwithyouonceyou…Theyneedtoknowyou’reintheircamp,you’retheiradvocate,you’renotjudgingthem,you’renottheretoscoldthemiftheydon’tdoitperfectly.Ithinkthat’sabigpartofwhatmakesagoodhealthcareprovider.That’sreallystillpartofartofmedicineratherthanjustitbecomingatechnicalendeavor.

Dr.LizLipski:[01:11:30][01:12:00]

Peoplecometoseeaclinicianbecausetheyhopethatthatclinicianisgoingtowalkdowntheroadwiththemtohelpthem.Forme,I’vealwaysbeentaughtthatmylifeisaboutservice.IthinkwhetherIgogetmyhaircut,somebody’sservingme.They’remakingmefeelbetteraboutmyselfbycuttingmyhair.Igobuynewclothes.It’sbecausetheymakemegoodforaminute.Ithinkwe’reallaboutservice.Oprahsaiditreallywell.Shesaid,“UsemeuntilI’musedup.”Idon’twanttobeusedupbutIwanttobeusedwell.It’slikeserveuntilwecan’tbutalsoremembertorenewourselvesbecausethat’sjustasimportant.

[01:12:30]

IthinkDavidJoneshadsaidsomanyoftimesthattherearen’tphysicianswhogointomedicinetobebadphysicians.Everybodygoesintothiswitharealhopethatthey’regoingtohelpalotofpeople.Ithinkthateverybodywhoisaclinicianreallyhelpsalotofpeople.Ijustthinkthatwiththismoreintegrativeandfunctionalmovementthatwegetthepeoplewhosay,“Yeah,butIthinkjustkeepingsomebodyinthedrugisn’treallythelongtermsolutionalways.”IstheresomeotherpieceofapuzzlethatI’mmissing?Ithinkthat’sreallywhatbindsthisfunctionalmedicinegrouporintegrativemedicinegroupstogetheristhatcuriositywherewe’realwayssaying,“Howcanweservebetteronepersonatatime?”

[01:13:00]Dr.O'Bryan:

You’reprobablythinking,whatdoIdonow?Youprobablyfeeloverloaded,informationoverload,analysisparalysis.Yourgeektermsthat’swaytoomuchinformation.Wewantyoutoknowyou’renotalone,thatthere’sacommunityhere.Whereshouldyougofromhereandwhatshouldyoudo?We’regoingtoshowyou.We’regoingtoshowyouwhattheexpertssaythatworkwithpeopledayinanddayouttoguidethemthroughhowtogetbacktovibranthealth.


Informationispowerbuttheinformationisonlypowerfulifyoufindtheinformation,andthenactonit,andputthatinformationintoplay.Wehavethetoolstodothatnow.Ifyouhaveafamilyhistory,whetherit’safamilyhistoryofa


[01:14:00]

lotofcancer,alotofheartdisease,alotofautoimmunedisease,therearesomanyupstreamtoolsthatwehavenowtofindoutwhatisyourspecificriskfactorsasanindividualbecauseevenbeyondautoimmunity,riskforcardiovasculardisease,heartattacks,strokes,pulmonaryembolism,whatever,it’snotjustcholesterol.There’sawholebunchofdifferentmodifiableriskfactors.

Youhavetofindwhatareyourmodifiedriskfactorsasanindividualsothatwecanthenguideyouonwhatlifestyleinterventions,whatthingstochangeaboutyourdiet,aboutyourstress,aboutyourexercise,orwhateveritmaybe.Samethinginautoimmunity.

[01:14:30]

Thisautoimmunediseaseepidemicissuchabigproblemandit’saffectingsomanypeople,somanypatientsbutsomanyextendedfamiliesofthosepatients.Ithasthelikelihoodofaffectingouroffspring,ourchildren,theyoungchildrenwehave,ourchildrenyettocome.It’sareallyimportantpublichealthissuethatneedstobeturnedaround.LikeIsaidbefore,it’snotgoingtobeturnedaroundwithamagicdrug.It’sgoingtobeturnedaroundwithmakingtherightchangestoourlifestyle,ourdiet,ourfoodsupply,ourenvironment.

[01:15:00] Thatisnotgoingtohappenbecausethepowersthatcontrolthefoodsupplyorthepowerthatpowersthatcontrolthesevariousaspectsoftheenvironmentandtheeconomyaregoingtomakethosechangesforus.It’sgoingtobedrivengrassrootsbypeoplewhoarefedupofbeingchronicallyillandneedthesystemtochange.

[01:15:30]

That’swhyaserieslikethisissoimportant.Youhavetogettheinformationouttothepeople,tothemassesthatareunwillingguineapigsinthisbigexperimentthat’screatingsuchchronicdisease.They’retheonesthataregoingtodrivethechangesinthewholesystembythechoicestheymake,andthedollarstheyspend,andhowtheydoit.

Dr.O'Bryan:[01:16:00]

I’msogratefultoallthepeoplethatvolunteeredtheirtimeforBetrayal,theresearchers,thescientists,theclinicians,thepatients,allofthem.Thesespeakershavemadeanimpactonmylifeandonmyhealth.I’mgratefulforyou.Youarebecomingequippedforyourself,yourfamily,yourlovedonessothattogether,wecanendtheunnecessarysufferingfromautoimmunediseases.

SuzanneBarker:[01:16:30]

IjustreallyappreciateDr.Tombecausehe’sreallybeenproactive.He’sreallygettingthemessageout.He’sdoingwebinars.He’sspeakingatdifferentconferences.Hehastheresearchbehindwhathe’ssaying.He’sgivingpeopledirectionandclearguidanceonhowtoprevententryofautoimmunedisease,notjusttreatthesymptomsin,andthepastwherethey’rejustsuppressingtheimmunesystem,andthey'renothelpingpeoplegethealthier.Ithinkthemessagethathe’sbringingisreallygoingtobringalotoflifeandalotofhopetopeople.Ireallyappreciatewhathe’sdoing.

Dr.MichaelAsh:[01:17:00]

I’veknownDr.O’Bryanforalongtime.Bothofusmetforaprocessofchangingandthinkingdifferentlyaboutthewaywewantedtohelppeople,andatthesame


time,hadmanysimilaritieswithwhatwe’realreadydoing.Ithinkwhathe’sbeenreallyexcellentofdoingisbringingthatinformationtothepopulationinsuchawaythatitmakessenseforthem,connectswiththem,andempowersthemtotakemoreresponsibility.

JonathanOtto: Doyouthinkthatischanging,honestly,there?

Dr.MichaelAsh: I’msurethatifpeopletaketherecommendationsthathemanagestopulloutfromtheseinterviews,they’lldefinitelychangetheirlife.

[01:17:30]Dr.LizLipski:[01:18:00]

Travelingaroundtheworld,tryingtomakeadifference,he’sallaboutserviceaswell,andthisisreallyabouthowdoweserve.It’scertainlynotabouthisownpersonalgain.It’sreallyabouthowdoweserve,howdowechangetheworld.WhatIloveabouttheworldnowisthatmedicineishappeningbecauseit’sinthehandsofthepeople.It’sontheinternet.It’sindocuserieslikethisone.It’sinsummits.It’sinradiointerviews.It’sinmedia.Peoplearesaying,“HowcanIbeempoweredtochangemyownhealth?”That’swhatIloveaboutthisandwhatIloveaboutTom.

Dr.NaliniChilcov:[01:18:30]

He’ssocommittedtoreallyhighquality,excellentmedicine.Also,he’snotonlyaneducatorofpatients,buthe’saneducatorofdoctors,andhasawidereachsothathe’salwaysontheleadingedgeofwhateverinformationisavailable,andhasthisgifttoreallyteachittopeople,totakecomplexthings,andmakethempragmaticandusefulwithpatientsanddoctors.That’sagreatgift.Noteveryonecandothat.


Hetakestheinformationhesharessoseriously.Heresearchesthis.Hestudies.Hecomesupandhepresentsitinwaysthatareeasytounderstand.ThewholeglutenthingIthoughtwassuchacomplexthing,andhe’sbrokenitdownintooneofthekeyscientificpointsyouneed,whathasbeenvalidated,howdoyoutranslatethatinformationthewaythatit’suseful.He’sageniusatit.I’msoexcitedthatheishostingthisautoimmunesummit,andthatwe’regoingtohelptransformliveswiththeinformationthathe’ssearchingfor.

JamesMaskell: TherearevariousheroesinthatstorybutIrealizedthatDr.O’BryanissomeoneIhavethemostrespectforbecausehetookthathero’sjourneywhenvery,veryfewpeoplearewillingtodothat.

[01:19:30]

I’mgoingtolookoutforwhatworkstobeabletoseehowwecanreallyscaletheimpactandmakeitchange.Tomreallyshowedthewayforwardonthat.Ithinkhiscontributiontodiseasesbeyondautoimmunediseasewillbefelt,maybenotacknowledged,butisbeingfeltallthetime.

[01:20:00]JonathanOtto:

Yeah,andinmanycases,butisn’tthatawesomethatit’ssotranscendentthatpeoplemayevenforgetwherethatcamefrom,butthat’sshowinghowwidespreadthatrippleisspreading.


Dr.O’Bryan,comeoverhere,man.Youdon’tworryaboutthat.Ididn’tknowwhatkindofimpactyouhadonJame’slife.

Dr.O'Bryan: Thankyou.

[01:20:30]JonathanOtto:

Yeah,man.Yeah,Idon’tthinkyousawthatthroughwhenyouthoughtaboutdoingwhatyoudid.Idon’tthinkyousawthatthatwouldresultinsomethinglikethis.

Dr.O'Bryan: No.No,it’snotnecessary.Youjustfollowyourbliss.Youjustdowhatyouknowyouhavetodo.Then,therippleeffectoccursasachainset.We’rebrothers.There’smanyofus.Thethreeofuswe’rebrothers.

JonathanOtto: Wow,yeah.

[01:21:00]Dr.O'Bryan:

Everyonethatsitsherefortheseinterviews,we’reallfamily.We’realltryingtocarrythemessageoutonewayoranotherinourworlds.

JamesMaskell:[01:21:30][01:22:00]

Yeah.Ileftbeinganinvestmentbanker11yearsago.Partly,thereasonwhyIleftisbecausemymentorsatnexttome,andhesaidhegotdrunkathisleavingdinner,andhesaid,“I’dbeensittingonthisdeskfor35years,andIfeellikeIwastedmylife.”That’sthemomentIdecidedtoquitwiththisdirection.Foralongtime,I'vemadeveryslowprogresstowardswhatIreallywanttodowithmytimeanditwasTomthatshowedthewaytoacceleratethattotensofthousands,hundredsofthousands,millionsofpeople.That’sthedifferencebetweenbeingatthecoalfaceandreallyclosingtheseachange.Iappreciatethat.

Dr.O'Bryan: ThankyouJames.Youmademyday.

JonathanOtto:[01:22:30][01:23:00]

Iloveit.Ithinkthat,Tom,inorderforyoutodotheworkthatyouneededtodo,youactuallyhadtopassthatbannerandbecauseyouinvestedsomuch,youwereabletocreatechangeslikewhatJameshad.It’sjustsoperfect.IreallyrespectandadmirethatDr.O’Bryan,thisstageisanimmensejourney,andyou'reawarrior,you'reacowboy,butthen,you'resurelyinthatplaceofimpartingeverythingthatyou’vedone,andyou'reasageistheultimateplaceofbeingabletoimparteverythingthatyou’veexperiencedandwhatyou’vegonethroughinordertoequipthegenerationoffightersthataregoingtotakethistothefinishline,andyou'recommittedtothattotheupmost.

Dr.O'Bryan: Yes.

JonathanOtto: Then,today,yougettheopportunity.Therewardsdon’tcome.Thatkindofreward,noonecanpayanysumofmoneytogiveyouthatrewardbutitcomesinaformofthiswhichnotmanypeoplewillgettoexperiencethatjourneyintheirlifeandyougettoexperiencethat,man.


Dr.O'Bryan:[01:23:30]

Mycreedinlifeincludesthisphrase,“Lifeisnobriefcandletome.It’ssortofasplendidtorchthatIhaveaholdofforthemoment,andIwanttopassontofuturegenerations.”That’sthegoal.Whatelseisthere?

Dr.DanKalish:[01:24:00]

IwanttotellyouwhyI’msoexcitedaboutyouparticipatinginthissummitbecauseIfeellikethere’ssomuchinformationonline,it’sveryconfusingforyoutogetaccurate,scientifically-validinformationthatyoucanreallytrust,andwhatthedoctorswhoareinthisprogramaredoingforyouisprovidingasafespacewhereyouknowthatyouhaveinformationfromleadingexperts,andclinicians,andscientiststhatisreliable,andactionable,andthatyoucanbelieve.Ireallystronglyendorsethisprogram.

Dr.O'Bryan:[01:24:30]

I’msogratefulthatyou’vejoinedustoday.Thankyousomuch.Iknowthatyou’velearnedalot,perhapshaveabetterunderstandingofwhatautoimmunediseasesareingeneralaswemoveforwardnowwithwhatdoyoudoaboutallthis.Intheepisodetomorrow,you’regoingtohearthreemajorthemes.Thefirst,whatisintestinalpermeability,theleakygut?I’mgoingtogiveyouvisuals.I’mgoingtogiveyouvideos.I’mgoingtoshowyouandgiveyouanunderstandingsothatyoureallygetwhatthisthingisandhowitcontributestothedevelopmentofautoimmunediseases.

[01:25:00]

We’regoingtotalkaboutvitaminDwhichIthinkisthemostimportantvitaminthatwehavetomakesureweget.MoreimportantthananyotherisvitaminDanditsroleinthewholedevelopmentandvulnerabilitytoautoimmunediseases.We’regoingtouserheumatoidarthritisasanexample.You’regoingtohearfrompeoplewhohavereversedtheircondition,whohavereducedtheirpain,andeliminatedtheirpain,andgottentheirlivesbackagain.

[01:25:30]

Withepisodestwo,three,four,five,six,seven,we’vetargetedtopicswiththisworldfamousscientists,andclinicians,andpatients.Makesureyoucomebackforeachepisode.Ifyoufeelthatyou’vegottenvalueoutoftoday,pleaseclickthebuttonsbelow,theshare,thelike,thecomment.Letusknowwhatthiswaslikeforyou.Tellyourfriendsaboutthis.Thankyousomuchforbeinghere.


EPISODE 1—THE AUTOIMMUNE EPIDEMIC: ROOT CAUSES AND SOLUTIONS SUMMARY AND ACTION ITEMS Howmanypeopleareaffectedbyautoimmunediseases?Thereare80millionpeoplesufferingfromautoimmunediseasesintheUSand150millionpeopleworldwide.Ifweincludethefactthatresearchersarenowseeingautoimmunemechanismsoccurringincancer,heartdisease,andbraindisorders,thisnumberwilllikelycontinuetorise.Whatisautoimmunity?Autoimmunityiswhenthebodynolongerrecognizesourowncellsassafeandlaunchesanattackagainstthem.Therearemanythingsthatcanchangetheshapeofyourcells.Toxins,stresshormones,bacterialparticles,andevenexcessivesugarcanchangetheshapesofyourcellsleavingthemmoresusceptibletobeingmistakenasharmfulintrudersbyyourimmunesystem.Andoncethebodyrecognizesyourowncellsasdangerous,itproducesantibodiestothosetissues.Certainfoodsandbacteriahaveaminoacidsequencesthatlookalotlikecellsfoundinourownbody.Ifourimmunesystemmakesantibodiesagainstthesefoods,thoseantibodiesmayalsotargetourowntissues.Thisiscalledmolecularmimicry.Anythingthatincreasesimmuneactivitycanincreasetheimmunesystem’sabilitytoattackhealthytissue.TherewerethreemainthingsmentionedinthisepisodebyDr.MarkHymanthatcauseirritationoftheimmunesystemtheywere…1.FoodReactions/Allergies2.Infections/MicrobeImbalances3.ToxinsWhatwerethetwothingsthatDr.Hymansaidwere“underlyingalldisease?”A.ExerciseandSleep B.DietandStressC.CommunityandSubstanceAbuse D.StressandSleepOurcurrentmodeloftreatingautoimmunitywithmedicationsdoesn’tseemtobeworking.Dr.PeterOsbornementionedsomeshockingnumbersregardingmedicalerrorintheUS.Hesaiditwasoneofthetopcausesofdeath.Doyourememberwhatpositionmedicalerrorstookinthetop10causesofdeath?A.Position10 B.Position5C.Position3 D.Position8SEEANSWERSONNEXTPAGE


MarkHyman:“It’sawholehostoffactorsthatinteractswiththeirgeneticsdependingonourenvironment,ourgenesthattriggerourparticularproblem.There’svariabilityinthepopulationsothatthesameinsultscancausemanydifferentautoimmunediseases.Thereareonlythreemaintriggersforautoimmunediseasewithacoupleofadd-ons.Dietandstressalwaysinfluenceeverydiseasebutthemainthreetriggersareallergens,microbes,andtoxins.Asfunctionalmedicinepractitioners,ourexpertiseisbeingabletodrilldownintoeachoftheseareasanddiscoverinanyparticularpersonwhat’sdrivingthatproblem.”Dr.PeterOsborne:“Ibelieveitbutit’snotabeliefjusttobelieve.It’sthetruth.Let’sjustanalyzewhatweknow,whatwe’velearned.TherewasastudythatcameoutjustacoupleofmonthsagoontheBritishMedicalJournal.(linktoarticle)Itwasareallygoodstudy.Itwasananalysisofthetopcausesofdeath.Whatthestudycametotheconclusionofisthatheartdiseaseandcancerwerethenumberoneandtwokillersbutthethirdleadingcauseofdeathwasmedicalerror.Now,whatdoesthatmean?Somebodywillsay,“Theyoverdosedonthedrug,”or,“No,theydiedinsurgery.”No,medicalerrormeanstheproperuseofprescriptionmedication.Ifwelookattheleadingcausesofdeath,andwesay,“Okay,howdowetreatthisthings?Thesystemthatwehave.Whatdoweusetotreattheseleadingcausesofdeath?”Weusemedicinebutmedicineisthethirdleadingcauseofdeath.Doesthatmakesensetoyou?That’sdata.Ididn’tmakethatup.That’srawempiricaldata.Whatittellsmeiswe’redoingthewrongthing...”ACTION ITEMS

Nowit’syourturntofindouthowtobalanceyourmicrobiome,yourstresslevels,andyourtoxinexposureswhileyoulearnabouttheoptimaldietthatworksforyou!FindaFunctionalMedicinepractitionerandgetstartedtoday.

“I have seen too much suffering. And it’s unnecessary suffering. After traveling the globe and interviewing some of the brightest medical minds on the planet, it is clear that there are simple options that can reduce and sometimes end the struggles of millions of people. It has been my dream to bring

these simple solutions to you and your loved ones so you can live long and vibrant lives filled with joy and hope. Thank

you for making this dream a reality.” Dr. Tom O’Bryan

Dr. O’Bryan is considered a ‘Sherlock Holmes’ for chronic disease and metabolic disorders. He is a clinician par excellence in treating chronic disease and metabolic disorders from a Functional Medicine Perspective. He holds Adjunct Faculty positions with the Institute for Functional Medicine and the National University of Health Sciences. He has trained thousands of practitioners around the world in advanced understanding of the impact of food related disorders and the development of individual autoimmune diseases.

Dr. Tom’s 2016 critically acclaimed ground-breaking book, ‘The Autoimmune Fix’ outlines the step-by-step development of degenerative diseases and gives us the tools to identify our disease process years before the symptoms are obvious.

TOM O’BRYAN, DC, CCN, DACBN

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