Trans Cranial Magnetic Stimulation (rTMS) setting up a ...Safety / side effects • The stimulation...
Transcript of Trans Cranial Magnetic Stimulation (rTMS) setting up a ...Safety / side effects • The stimulation...
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Trans Cranial Magnetic Stimulation (rTMS)setting up a service in the Private sector
Carol TurnbullCEO, Ramsay Health Care SA Mental Health services
APHA Congress October 2011
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What is TMS?
• A relatively new treatment for depression• Relies on direct stimulation of the brain
using a magnetic pulse to generate brief electrical currents that stimulate nerve cells in the regions of the brain involved in depression.
• No anaesthetic required• No cognitive side effects• Treatment can be administered by Nusing
staff/trained technicians
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Role of rTMS
• rTMS is used to treat depression.• Depression is very common – approx 55% patients
admitted to RHC private psychiatric hospitals in Adelaide had depression.
• Not all patients respond to antidepressant medication and/or psychological therapies.
• Antidepressant medications have many side effects so are not always well tolerated.
• Sometimes trials of several different antidepressants are needed and are still unsuccessful.
• Patients who do not respond to antidepressants are often treated with electroconvulsive therapy (ECT).
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How does TMS work?
• A magnetic field created by a coil placed close to the scalp induces a current in the cortex
• This current causes depolarization and stimulation of a local cortical region
• Provided the stimulus is of sufficiently low current and frequency, a generalized seizure is not produced
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Our Service – how we started
• Psychiatrist proposal• Committee established• Strong Research and Evaluation
component• Consistent with RANZCP position
statement• Costings• Approvals under Research protocols
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Costs
A typical commercial TMS device and chair.The total cost of equipment,software and training is over $100,000.
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Training
• Professor Paul Fitzgerald (The Alfred Hospital in Melbourne) provided training for service directors and Nursing staff
• Funded by Ramsay Health Care• Assessment and suitability criteria
established• Practical training in mapping the position
of the DLPFC (Dorsolateral prefrontal cortex) and the motor threshold
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Training cont’d
• Practical session and operation of the rTMS device
• Treatment and research protocols and policies
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Staffing and Administration
• Two Clinical Directors (Psychiatrists)
• Registered Nurses• Psychologist (Research Assistant)
• Clinical Governance by the rTMS Committee which meets every 3 months.
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rTMS Suite
• An area of the hospital identified• Treatment room• Waiting room• Office• Coil cooling room• MagPro R30 rTMS machine and two MCF
coils purchased• Comfortable chair • Disposable earplugs
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Clinical interest
• Psychiatrist “interest” evening with the machine
• CME
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Referral
• Credentialled Psychiatrists
• Outpatient status but must have private health cover
• Inclusion criteria include MDD, over 18yrsno history of seizures, no metal in head (eg surgical clips) not psychotic, willing to attend 3-5 mornings/week for an hour (up to six weeks).
• Must be able to speak and understand English
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Initial Assessment
• Locate motor cortex • Determine intensity of motor threshold• Measure 6cm forward to DLPFC• Make individual patient template
• These parameters determine the location and intensity of treatment
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Safety / side effects
• The stimulation produces a loud audible ‘click.’ Patients wear earplugs to prevent acoustic trauma.
• There is a very small risk of seizures – usually with higher stimulus intensities or patients with low seizure threshold (e.g. on tricyclics, or with a past history of epilepsy)
• Small rates of induction of mania or hypomania are noted – smaller rates than with antidepressant medication
• Some transient treatment related effects– Scalp pain or discomfort during stimulation (due to scalp nerve or
muscle stimulation during treatment)
– Headaches
• No cognitive side effects noted in studies
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Ethics Approval
• All patients treated participate in Research protocol
• Approved by Ramsay Health Care SA Ethics Committee
• All patients give written informed consent
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tTMS
• 222 referrals received from 51 psychiatrists
• 160 patients accepted for treatment• 92 completed first course, 18 completed
2nd course, 9 maintenance, 1 auditory hallucinations patient
• Only rTMS service in SA
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Funding
• Currently no Medicare item number• Costs of treatment not reimbursed by
Private Health funds• 2005 application made to MSAC by
RANZCP • More evidence now supporting efficacy of
rTMS with antidepressant medication as the preferable comparator
• Application made to Medicare (MSAC)for item number
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Obstacles
• Challenging financial aspect
• Coils overheating
• Mechanical issues – support arm
• Software issues
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• Primary outcome measure: 21 item Hamilton Rating Scale for Depression(HAMD; Hedlung and Vieweg, 1979)
• Montgomery-Åsberg Depression Rating Scale (MADRS; Montgomery & Åsberg, 1979)
• Zung self-rating depression scale (Zung, 1965)
• 14 item Hamilton Anxiety Rating Scale (HAMA; Hamilton 1959)
Measures
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Results – Overall Efficacy
0
10
20
30
40
50
60
HAMD MADRS ZUNG HAMA
Baseline (n=84)
Post-treatment(n=84)
Significant improvement on all outcome measures at the p<.001 level (paired t-test results)
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Conclusion
• Effective• Well tolerated• Advantages over alternate treatment
methodologies i.e. no sedation or agitationno weight gainno sexual dysfunction
rTMS provides another valuable treatment option
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Enhanced rTMS
• Recently commenced stage 2
• rTMS plus Mindfulness group therapy, Internet CBT, Relaxation and Gym (Physical exercise)
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Thank youAny questions?