Towards Priorities for Aging Research - Scott Needham at SENS6
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Transcript of Towards Priorities for Aging Research - Scott Needham at SENS6
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Towards Priorities for Aging Research
Scott NeedhamSeptember, 2013
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Who & Why?
• Leading Technology Group has been investing in life sciences field
• Our future investment focus is on SENS type opportunities, in particular vascular aging
• Here we discuss the prioritisation approach that lead to this decision
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Aim: Priorities for Aging Research
• Ideally, with a SENS view, we would prioritise instances of aging damage
• No standard definitions or demographic data on damage, so we prioritise disease
• We use Australian Burden of Disease Data• Here we briefly review the path to our
approach and the results
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Character of Mortality
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Disease Curves Vary
(Simms 1946) (Kohn 1963)
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Disease Curves Vary Over Lifespan
(Horiuchi, Finch et. al. 2003)
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High-level Findings1. Accelerate in old age/post reproductive:– Dementia (Vascular & Alzheimer’s)– Several infectious diseases (Influenza)– Accidental injuries associated with frail
musculoskeletal system (Falls, Suffocation etc)– Digestive system (Bowel obstruction)– Genital/urinary system (Kidney disease)
2. Decelerate in old age/post reproductive– Life style: heavy drinking (Liver disease), smoking (Lung
cancer), and obesity (Type 2 Diabetes)– Disease history (Rheumatic heart disease, Hepatitis)– Genetic factors (Multiple sclerosis, some Cancer)
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Summary Interpretation
1. Accelerating: dominated by senescent processes from normal metabolism
2. Decelerating: dominated by individual specific risk factors
• With a focus on aging, our ranking should– Over weight diseases that accelerate– Under weight diseases that decelerate
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Prioritisation
• Several methods were considered:– Rank by old age mortality growth rate and
acceleration– Exclude risk factor associated deaths
• Two simple ranking methods chosen. Diseases are ranked by their relative:1. % of Deaths for Ages 60+, post reproductive2. % of Deaths for Ages 85+, oldest old
• DALYs too, largely aligned
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Increasing Ranking
Genital/Urinary
Acute Respiratory
Dementia
Digestive
Falls
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Steady-Decreasing Ranking
COPD
Type 2 Diabetes
Lung Cancer
Suicide
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Cancer
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Cancer
Prostate
Colorectal
Breast
Brain
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Cardiovascular
All Other
Cardiovascular
Cancer
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Vascular Aging
All Other
Cardiovascular
Cancer
IschaemicHeart Disease and Stroke
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Current Research Funding
(Gillum, Gouveia et al. 2011)
Mortality (All Ages) Funding (NIH)
IschaemicHeart Disease and Stroke
33%
6%