Optical Sensor Platform By Modular Assembly of Organic Electronic Devices:

Towards a Smart Bandageg

Marc Koetse,Gert van Heck, Peter Rensing, Fokko Wieringa Bart Allard Peter Kruijt Nicole Wieringa, Bart Allard, Peter Kruijt, Nicole Meulendijks, Herman Schoo

Holst CentreHigh Tech Campus 31 High Tech Campus 31 5656 AE EindhovenThe Netherlands

Contents

2

• Introduction

• Organic devices for smart bandage applications• Organic devices for smart bandage applications

• Proof of principle

• Conclusions

Marc Koetse – Smart Bandage – SAS2008 – Atlanta

3

Holst Centre: Concept

• Creating generic technologies, time to market 3..10 years• Partnering with industry and universities• Open innovation through precompetitive shared programsp g p p p g• Critical mass: currently over 150 researchers, residents and staff

Wireless Autonomous SystemsTechnology Autonomous Transducer Solutions

yin

Foil

Technology Integration

© Holst Centre

Marc Koetse – Smart Bandage – SAS2008 – Atlanta

4

System-in-foil Program Line

Aim:• The development of cost effective advanced flexible electronic devices

• R2R technology, low cost materials and processesR2R technology, low cost materials and processes• Device design

Examples of current developments:• Organic lighting and signage devices (flexible OLED’s)• Flexible sensor tags and systems

Marc Koetse – Smart Bandage – SAS2008 – Atlanta

OLED signage Smart BlisterFlexible ‘smart bandage’

55

Smart Bandage: In Plane Optical Sensor Platform

• Smart bandageBandage with monitor functionAvoid infections wound damageAvoid infections, wound damage

• Organic devicesThin; Light weight; Cheap; Bendable; g g ; p;Manufacturing on foil

• Many possible targets HealthcareAgro/foodAgro/foodDefense and safety

Marc Koetse – Smart Bandage – SAS2008 – Atlanta

6

Platform of Holst Technology

• Printing LEP and PV blends • Barrier foils • Foil integration • Foil integration • Printed contact lines • Organic driving and readout circuitry • Lithography on foil g p y• Low power micro electronics (WATS)

Marc Koetse – Smart Bandage – SAS2008 – Atlanta

7

Wound monitoring: Survival of the flap

• Optically monitoring perfusion in wound area

• Pulse-Oximeter in reflectionMeasure expansion of arteries (pulse)Measure color of blood (oxygen saturation)Measure color of blood (oxygen saturation)

Marc Koetse – Smart Bandage – SAS2008 – Atlanta

8

Test case: Pulse-oximeter in Foil

• 1st stage: pulse meterOne wavelength

• 2nd stage pulse-oximeter2 wavelengths: red 660 nm, NIR 800/900 nm

• Photodiodes and Leds in same plane: printing required

• Electronics Led drivingDiode readout Si or organicIntegration of Si in Foil TechnologyUltimately in a body area network Ultimately in a body area network

Marc Koetse – Smart Bandage – SAS2008 – Atlanta

Design

9

• GlassDouble side processing

• FoilModular: diodes and LEDs manufactured on separate foils

• Top emissive PLEDs• Bottom receptive OPDs

Active layerCathode

SubstrateBarrier/Encapsulation

AnodeActive layer

Marc Koetse – Smart Bandage – SAS2008 – Atlanta

10

Printing

• DiodeP3HT/PCBM ratio 1:1 – 1:4high spectral response over broad rangeForgiving: layer thickness 100-200 nmlayer thickness 100 200 nmHigh boiling solvents give improved efficiency

• LEDMerck Red (Gen 1)

Marc Koetse – Smart Bandage – SAS2008 – Atlanta

Printed Photodiodes

11

• All printed device Pedot and active layer (ink 1)

• High Currents• High Currents• High leakage current homogeneity not yet optimal• Layer thickness: 150-450 nm (freestanding)

20

15

2)

Voc = 0.576;Isc = 10FF = 0.564 MPP = 4.12

5

cm2 )

Voc = 0.542;Isc = 8.71FF = 0.257 MPP = 1.21

10

5

0C

urre

nt (

mA/

cm^2

-5

0

rren

t Den

sity

(mA/

c

-5

-10

C

1.00.80.60.40.20.0-0.2-0.4

-10Cur

1.00.80.60.40.20.0-0.2-0.4Bi (V)

Marc Koetse – Smart Bandage – SAS2008 – Atlanta

Bias (V)Bias (V)

Top emitting PLEDs

12

• Red emitting material (Merck Gen 1)

30

25

W/s

r m2 n

m)

20

15

10

5

ectra

l Rad

ianc

e (1

0-3W

0 Spe

750700650600550500wavelength (nm)

Marc Koetse – Smart Bandage – SAS2008 – Atlanta

Foil Integration

13

• Modular approach

• ElectronicsLogarithmic amplification (AD8305aru)DC filteringDC filteringNoise filtering 0.5-15HzContinuous driving and read out

Marc Koetse – Smart Bandage – SAS2008 – Atlanta

First all Organic Prototype: Proof of Principle

14

• SignalDC signal ca. 10 µAAC signal ca 50 nA

• Works!PPG comparable to commercial pulse-oximeter (Nelcor N200)AC signal ca. 50 nA

S/N ~10 (AC)

pulse oximeter (Nelcor N200)Heat generationHigher efficiency emitter needed

Sign

al (a

.u.)

Organic Nelcor N200

Marc Koetse – Smart Bandage – SAS2008 – Atlanta

543210Time (s)

Resume

15

• In plane optical sensor arrayPulse meter realized

Organic sensor NodeOrganic sensor NodeFabrication technologyIntegration technology

Platform for other applicationsf dIntegration of organic and

classic technology

• Short Term OutlookShort Term OutlookOptimize with more efficient materialsOptimize printing strategiesI i d f ilIntegrate organic read-out foil

Marc Koetse – Smart Bandage – SAS2008 – Atlanta

Acknowledgements

16

• Holst CentreSmart Bandage Team: Gert van Heck, Peter Rensing, Bart Allard, Ruben Sharpe, Herman Gert van Heck, Peter Rensing, Bart Allard, Ruben Sharpe, Herman SchooFoil Integration Team: Erik Veninga, Jeroen van den Brand, Andreas DietzelP i ti T Printing Team: Nicole Meulendijks, Peter Kruijt, Jasper Michels, Marcel Tijdink Micro Electronics Integration: Jef van de Molengraft, Julien Penders

• TNO / Erasmus Medical Centre RotterdamBiomedical Engineering: Fokko Wieringa Fokko Wieringa

Marc Koetse – Smart Bandage – SAS2008 – Atlanta

17

Reaching out to cooperate

Benefits of Joining the Holst Center

•Access to relevant Holst background IP & Knowhow

•Joint Development Programs with Industrial Partners

•Facility & Cost sharing

Marc Koetse – Smart Bandage – SAS2008 – Atlanta