TOSOH BIOSCIENCE

Tosoh Bioscience

TOSOH BIOSCIENCE 2

TOSOH CORPORATION

Tosoh Corporation is a diversified global chemical company with a strong reputation in basic chemicals, petro-chemicals, and specialty products. Founded in 1935 (Toyo Soda Manufacturing), Tosoh has expanded into high value-added businesses such as organic chemicals, bioscience, quartzware, and advanced electronic materials.

Net sales 2011 (ended 31.3.11): 8.2 bn $

Employees worldwide >11000

TOSOH BIOSCIENCE 3

TOSOH CORPORATION

Tokyo Research Center

Head QuartersNanyo Complex3.7 million sq. meters• Chemical Laboratories• Technology Development &

Engineering Centers• In-house Power Generation

1,035,000 KW

TOSOH BIOSCIENCE 4

PRODUCTSPetrochemicalsOlefinsPolymers

BasicChlor-alkaliCement

SpecialtyOrganic ChemicalsBioscienceElectronic MaterialsSpecialty Materials

TOSOH BIOSCIENCE 5

SPECIALTY GROUP

•Yttria-stabilized Zirconia Powders & Compounds•YTZ® Grinding Media•Electrolytic Manganese Dioxide•Zeolite Molecular Sieves•Zeolite for Catalysts

Specialty Materials

•MDI – methyl diphenyl diisocyanate; Ethyleneamines•Polyurethane Catalysts•Bromine; Hydrobromic Acid •Flame Retardants•Chelating Agents •Solvents; High-purity Ethylene Dichloride

Organic Chemicals

Electronic Materials•Silica Glass Materials•Fabricated Quartzware•Machined Quartzware•Sputtering Targets•Process Kit Management

TOSOH BIOSCIENCE 6

Diagnostics• Fully Automated Random-Access Enzyme

Immunoassay System• Random-Access Enzyme Immunoassay System • Reagent System• Automated Glycohemoglobin Analyzers• Real-Time Fluorescence Monitoring System

Separations• High Performance Liquid Chromatography

Columns • Separation Media for Bio-Pharmaceutical

Purification• GPC Systems

SPECIALTY GROUP - BIOSCIENCE

TOSOH BIOSCIENCE 7

SEPARATION BUSINESS UNIT

Liquid chromatography columns, resins & instruments: • TSKgel® HPLC columns from capillary to preparative dimensions

• TSKgel® and TOYOPEARL® bulk resins for the purification of

biomolecules by preparative / process chromatography

• EcoSEC GPC instrument

*TSK = Toyo Soda Kogyu = manufactured by Toyo Soda

TOSOH BIOSCIENCE 8

TSKgel® HPLC COLUMNS

Size Exclusion Chromatography• Aqueous: silica based SW, polymer based PW • Organic (GPC): polymer based Alpha-, H-type

Ion Exchange Chromatography• Porous, nonporous diverse base matrices, STAT

Reversed Phase Chromatography• Silica & polymer based, Fast LC (2µm), NPR

HILIC – Hydrophilic Interaction• Silica based: Amide-80, NH2-100

HIC – Hydrophobic Interaction

Affinity Chromatography

TOSOH BIOSCIENCE 9

TSKgel® & TOYOPEARL® RESINS

Size Exclusion Chromatography• Pore size 50 Å up to > 1000 Å

Ion Exchange Chromatography• Weak and strong anion & cation exchanger

HIC – Hydrophobic Interaction• Various hydrophobicities and pore sizes

Affinity Chromatography• rProtein A, active, reactive and group specific resins

TOSOH BIOSCIENCE

• Technical hotline• Application support

by phone and „on site“• Catalog, technical literature• Customer magazine• Column packing assistance• Training courses• Customer seminars• Internet:

www.tosohbioscience.com- News- Detailed product information- Application database

TOSOH Bioscience Services

TOSOH BIOSCIENCE 11

The World of Tosoh Bioscience

Tosoh Bioscience LLCThe Americas Tosoh Corp.

Asia, Australia

Tosoh (Shanghai) Co., Ltd.China

Tosoh Bioscience GmbHEurope, Africa

TOSOH BIOSCIENCE 12

Tosoh Bioscience in Europe

Tessenderlo (B): Customer ServiceWarehouse PurchasingHR & IT

Stuttgart (D): Technical support (6)Sales & Marketing (13)

TOSOH BIOSCIENCE

Further information:

www.tosohbioscience.comwww.tskgel.com

www.toyopearl.comwww.ecosec.eu