TOP FIVE ARTICLES · EULAR outcome measures for pSS – Update The EULAR Sjögren’s task force...
Transcript of TOP FIVE ARTICLES · EULAR outcome measures for pSS – Update The EULAR Sjögren’s task force...
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TOP FIVE ARTICLES 2010
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Años
Score
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Años
Score
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EULAR outcome measures for pSS – Update
The EULAR Sjögren’s task force
The Steering committeeC. Vitali (Italy)X. Mariette (France)S. Bowman (UK)E. Theander (Sweden)A. Tzioufas (Greece)H. Boostma (Netherlands)JE. Gottenberg (France)M. Ramos-Casals (Spain)T. Dörner (Germany)
The experts of the EULAR pSS study groupKarsten Asmussen, Soren Jacobsen, Denmark; Johannes WJ Bijlsma, Aike A Kruize, Hendrika Bootsma, Cees Kallenberg, The Netherlands; Stefano Bombardieri, Salvatore De Vita, Nicoletta Del Papa, Roberto Gerli, Carlomaurizio Montecucco, Guido Valesini, Claudio Vitali, Italy; Arthur Bookman, Canada; Simon J Bowman, David Isenberg, Adrian Jones, Elizabeth Price, Nurhan Sutcliffe, UK; Johan G Brun, Roland Jonsson, Roald Omdal, Norway; Steven Carsons, Gabor Illei, Ann Parke, Frederick B. Vivino, USA; Xavier Mariette, Jacques Eric Gottenberg, Jean Sibilia, Eric Hachulla, Valerie Devauchelle, Alain Saraux, France; Thomas Dörner, Germany; Menelaos Manoussakis, Athanasios Tzioufas, Greece; Sonja Praprotnik, Matjia Tomsic, Slovenia; Manel Ramos Casals, Spain; Josef Smolen, Austria; Serge Steinfeld, Belgium; Elke Theander, Sweden. Thomas Mandl, Sweden, Cristina Vollenweider, Argentina, Robert Fox, USA; Gabor Illei, USA; Arne Hansen, Germany; Manuel Anaya, Spain; Yi Dong, Li Mentago, China; Elaine Alexander, USA; Kathy Moser, USA; Anthony Rosen, USA; Hal Scofield, USA; Bill St Clair, USA; Takayuki Sumida, Maureen Rischmueller, Australia; Oscar Epis, Italy, Ng Wan-Fai, UK; Roberta Priori, Italy; Roser Solans Laqué, Spain; Joaquim Coll, Spain; Alan Baer, USA; Valeria Valim, Brazil.
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Stimulated whole salivary flow, mean (ml(minute)
p < 0.05p < 0.05
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Metodología (PRISMA, PICOTS, Cochrane)
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Ensayos clínicos randomizados
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1. Papel de la biopsia cutánea en el diagnóstico del SSp
2. Lento daño acumulado, muy bajo voltaje lesión sistémica
3. Importante disponer de índices validados de actividad/cronicidad
4. Rituximab, prometedor pero necesario confirmar
5. Escaso nivel de evidencia disponible para el tratamiento