TO and THRU LECTURE 10
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Transcript of TO and THRU LECTURE 10
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rh
Lecture 9 Slides
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LIPIDCATABOLISM
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lipid menagerie
phospholipid
triglyceride
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from McDonalds to Metabolism…
fig17-1
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from McDonalds to Metabolism…
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The chylomicron: a lipoprotein
fig17-2
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mobilization ofglycerol
fig17-4
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fig17-5
connecting the FAto CoA-SH
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fig17-5
connecting the FAto CoA-SH
goodleavinggroup
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fig 19-1
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Carnitine: Charon* of the matrix!
* you know, the boatman on the River Styx
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Carnitine: Charon* of the matrix!
* you know, the boatman on the River Styx
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fig17-6
Transport of acyl-carnitine into the matrix
rate-limiting step for oxidation of FAs
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oxidation offatty acids:three steps,one new…
fig17-7
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b-oxidation:taking ittwo carbonsat a time
fig17-8
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fig17-8
iterated metabolic pathway
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b-oxidation challenges…
monounsaturated FA
odd-carbon FA
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b-oxidation challenges…
monounsaturated FA
polyunsaturated FA
odd-carbon FA
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b-oxidationof a mono-unsaturatedfatty acid
fig17-9
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b-oxidation challenges…
monounsaturated FA
polyunsaturated FA
odd-carbon FA
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what about3-carbonleftovers?
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what about3-carbonleftovers?
fig17-11
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fig 17-11
what about3-carbonleftovers?
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the coenzyme B12 reaction
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deoxyadenosylcobalomin orcoenzyme B12
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comparisonof FA oxidationmitochondriavs.peroxisomes
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catalase
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fatty acidmetabolismin seeds…
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enzyme evolution in fatty acid oxidation
fig17-15
oneprotein
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ketone bodies
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fig17-18
formationof ketone bodies fromAc-CoA
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formation of ketone bodies from Ac-CoA
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formation of ketone bodies from Ac-CoA
fig17-18
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formation of ketone bodies from Ac-CoA
fig17-18
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fig17-18
formation of ketone bodies from Ac-CoA
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metabolism of a ketone body
fig17-19
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fig17-19
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fig17-19
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fig17-19
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liver synthesis of ketone bodies when TCA activity is low
fig17-20