TO and THRU LECTURE 10
description
Transcript of TO and THRU LECTURE 10
rh
Lecture 9 Slides
LIPIDCATABOLISM
lipid menagerie
phospholipid
triglyceride
from McDonalds to Metabolism…
fig17-1
from McDonalds to Metabolism…
The chylomicron: a lipoprotein
fig17-2
mobilization ofglycerol
fig17-4
fig17-5
connecting the FAto CoA-SH
fig17-5
connecting the FAto CoA-SH
goodleavinggroup
fig 19-1
Carnitine: Charon* of the matrix!
* you know, the boatman on the River Styx
Carnitine: Charon* of the matrix!
* you know, the boatman on the River Styx
fig17-6
Transport of acyl-carnitine into the matrix
rate-limiting step for oxidation of FAs
oxidation offatty acids:three steps,one new…
fig17-7
b-oxidation:taking ittwo carbonsat a time
fig17-8
fig17-8
iterated metabolic pathway
b-oxidation challenges…
monounsaturated FA
odd-carbon FA
b-oxidation challenges…
monounsaturated FA
polyunsaturated FA
odd-carbon FA
b-oxidationof a mono-unsaturatedfatty acid
fig17-9
b-oxidation challenges…
monounsaturated FA
polyunsaturated FA
odd-carbon FA
what about3-carbonleftovers?
fig17-11
what about3-carbonleftovers?
fig17-11
fig 17-11
what about3-carbonleftovers?
the coenzyme B12 reaction
box17-2
deoxyadenosylcobalomin orcoenzyme B12
box17-2
box17-2
comparisonof FA oxidationmitochondriavs.peroxisomes
box17-13
catalase
fatty acidmetabolismin seeds…
fig17-14
enzyme evolution in fatty acid oxidation
fig17-15
oneprotein
ketone bodies
fig17-16
fig17-18
formationof ketone bodies fromAc-CoA
formation of ketone bodies from Ac-CoA
fig17-18
formation of ketone bodies from Ac-CoA
fig17-18
formation of ketone bodies from Ac-CoA
fig17-18
fig17-18
formation of ketone bodies from Ac-CoA
metabolism of a ketone body
fig17-19
fig17-19
fig17-19
fig17-19
liver synthesis of ketone bodies when TCA activity is low
fig17-20