LaRosa JC et al. N Engl J Med 2005; available at: http://www.nejm.org.

TNT: Baseline and final LDL cholesterol levels LDL cholesterol level

Atorvastatin 10 mg (n=5006)

Atorvastatin 80 mg (n=4995)

Mean baseline LDL cholesterol levels (mg/dL)

98 97

Final LDL cholesterol levels (mg/dL)

101 77

TNT: Primary efficacy outcomes

LaRosa JC et al. N Engl J Med 2005; available at: http://www.nejm.org.

Outcome Atorvastatin 10 mg (n=5006)

Atorvastatin 80 mg (n=4995)

Hazard ratio(95% CI)

p

Total major cardiovascular events (%)

10.9 8.7 0.78(0.69-0.89)

<0.001

•Death from coronary heart disease (%)

2.5 2.0 0.80(0.61-1.03)

0.09

•Nonfatal MI (%) 6.2 4.9 0.78(0.66-0.93)

0.004

•Resuscitation after cardiac arrest (%)

0.5 0.5 0.96(0.56-1.67)

0.89

•Fatal or nonfatal stroke (%)

3.1 2.3 0.75(0.59-0.96)

0.02