The Role of Very High High-Sensitivity C-Reactive Protein levels on Mortality after Stroke

Supplementary Material

Table 1: Sensitivities, Specificities, Positive and Negative Predictive Values for electronic identification of comorbidities, using

manual chart review as the reference standard

Sensitivity(95% CI)

Specificity(95% CI)

PPV(95% CI)

NPV(95% CI)

Cancer1 (0.02, 1) 0.76 (0.65, 0.81) 0.08 (0.00, 0.38) 1 (0.90, 1)

Hypertension0.83 (0.64, 0.94) 0.71 (0.44, 0.90) 0.83 (0.64, 0.94) 0.71 (0.44, 0.90)

Atrial fibrillation1 (0.59, 1) 0.95 (0.83, 0.99) 0.78 (0.4, 0.97) 1 (0.90, 1)

Diabetes0.73 (0.39, 0.94) 1 (0.9, 1) 1 (0.63, 1) 0.92 (0.79, 0.98)

CAD0.5 (0.16, 0.84) 0.89 (0.75, 0.97) 0.5 (0.16, 0.84) 0.89 (0.75, 0.97)

PPV=Positive predictive value; NPV=Negative predictive value; CAD = coronary artery disease; confidence interval. The exact binomial method was used to compute the 95% confidence intervals.

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Figure 1: Plots of Schoenfield residuals versus time for each covariate

Figure Legend: The lowess curves are generally horizontal, indicating little departure from the proportional hazards assumption

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