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Health Resources Industry

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Analysis of the Health Resources market

Doctors Nurses

Pharmacists Etc.

Outpatient careHospital care

Long-term carePharmaceuticalsMedical devicesBiotechnology

Health Resources

Human Resources

Health Spending

Tissue engineering

Profile

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Attractiveness of the Health Resources market by region1.United states of America:

15% of total population is 65> years old (accounts for 50 million

inhabitants)

Expanded consumer access to health care

through the 2010 Patient Protection and

Affordable Care Act (ACA)

Spending in 2014: $3 Trillion with a GAGR

of 4.9%

2. Europe Union:

20% of the total EU population which accounts for 100 million

inhabitants are 65 years and older

Lengthening life expectancies

Spending in 2014: $2 Trillion with a GAGR

of 2.5%

N.B.: Spending for the world reached $10 Trillion in 2014

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Pharmaceutical Industry

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Analysis of the Pharmaceutical industry

Segments:

Originator chemical drugs, generics,over-the-counter drugs, active pharmaceutical ingredients, excipientsand biosimilars.

Profile

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Attractiveness of the Pharmaceutical industry

World spending in 2014: $1,6 Trillion

CAGR: 6.4%

CAGR: 2.2%

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50% of the largest pharmaceutical companies are based in the US and the rest in the EU

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Spending per capita in 2016

Belgium in as among the top 15 countries for Pharma spending per capita

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Tissue Engineering Market

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Analysis and attractiveness of the Tissue engineering market

Overview

Market size $89.7 billion in 2016 at a CAGR of 8.4% with the US in the lead followed by the EU.

Industry classificationTissue engineering is present mainly in :• Pharmaceutical• Biotechnology • medical devices sector

Market classification by applicationOrgan and Tissue Regeneration,

cardiovascular, oral care, dermal, orthopedic, dermatology, oncology,

neurology and urology.

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Tissue engineering: The Oral care segment

Dental in Numbers:

Oral care in Numbers

National dental care expenditure reached $111 billion in 2012 in the US. Spending per patient in USA on dental by age:

1. USA

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Dental in Numbers:

Oral care in Numbers2. Europe

The EU27 spending on dental was equal to $79 billion in 2012 with a global CAGR of 5.7%. Different dental segments by share in the European market:

Peptide-based hydrogel dentalapplications

Tissue engineering: The Oral care segment

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Caries prevention Periodontal medication

Teeth bleaching

Tissue engineering and Regenerative medicine Improve Dental and Periodontal opportunities

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What is it about

What can the technology do

What would be required

How big is the market

Tissue engineering: Dental applications Prevention from caries by Peptide-based hydrogel

Combining the hydrogel with different compounds and using it as a platform.

A tray would be important or simply transforming the hydrogel into toothpaste.Furthermore, Fluoride should be mixed with the gel.

Delivers protective compounds locally to fight against teeth corrosion and caries perseverance.

Fluoride usage in Belgium exceeds 85% of the total population (So demanded).

Existing applications: Fluoride gel.Examples of existing products:o Oral-B® Minute-Foam® 1.23% APF Topical Fluoride poured in a

tray and costs >$35o Oral-B®Neutra-Foam®2.0% Neutral Sodium Fluoride poured in a

tray and costs >$35

>25% consume drinks with high sugar level > 30% consume alcohol

>85% consume candies.

15% have had difficulty chewing, biting and eating food because of

caries

According to European polls:

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Tissue engineering: Dental applications Teeth Whitening hydrogel

What is it about

What can the technology do

What would be required

How big is the market According to European polls:

-7% felt embarrassed because of the appearance of their teeth-4% of Europeans have avoided a conversation or reduced their participation in social because of their teeth colours.-In Belgium, More than 20% consumes tobacco regularly and on daily basis. The American Association of Orthodontists also found that nearly 90% of patients requested tooth whitening.

Examples of existing products:o Opalescence is one of the best in teeth whitening. (400 Euro for the kit includes 4 syringes of 1,2mL, a toothpaste and a tray.)o Whiter Image: US$ 55 for the deluxe kit includes 2 syringes of 1,2mL and a tray (or not it depends)

Hydrogen Peroxide or Carbamide Peroxide should be added to the gel. Also, The tray, that contains the Hydrogel, should be placed on the patient’s teeth for more or less 8 hours (during the night).

Mixing the Hydrogel with other elements for teeth bleaching applications.

Turn degraded teeth into whiter ones by applying the hydrogel locally using a tray.

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Tissue engineering: Periodontal application Medication for gum matters

What is it about

What can the technology do

What would be required

How big is the market

Carries and distributes antibiotics (or other combinations) locally to cope with gum bleeding, periodontal pockets and other irritating concerns.

Chlorhexidine, doxycycline andminocycline can be added to the hydrogel depending on the issue that should be treated.

Joining antibacterial elements with the hydrogel to tackle gum issues.

According to the Department of Health studies: -16% have sore gums or irritation.-Around 50% of adults have early stage of gum diseases (64 millionIn the USA).-Half of adults have gum pockets and 20% of those are 15-18 years old.-8 in 100 adults were found to have severe gum pockets that, eventually, need surgery.

Existing applications for gum treatments: o Perio-cleaning at the dentist is more than US$ 200.o G.U.M Perio-Balance Oral Probiotic (30 lozenges £14.51)o Boots Co-Enzyme Q10 (30 capsules, £4.99) o Colgate Peroxyl Oral Rinse (300ml, £3.58)o Corsodyl Spray (60ml, £5.15)o Gengigel Gel (20ml, £6.99)