Tiro Ideas
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5/24/2018 Tiro Ideas
1/15
h|x|wtw atv|t wx awxh|x|wtw atv|t wx awx
h|x|wtw atv|t wx awx
h|x|wtw atv|t wx awx
Ytvtw wx `xw|v|tYtvtw wx `xw|v|tYtvtw wx `xw|v|tYtvtw wx `xw|v|t
Vxwt wx U||vtVxwt wx U||vtVxwt wx U||vtVxwt wx U||vt
Profesora titular. Ctedra de Bioqu
LlanLlanLlanLlan
Jefa de Trabajos Prcticos. Ctedra de Bio
de
RodRodRodRod
Ayudante Alumna por Concurso. Cte
Facultad de
Ruiz Daz, DaniRuiz Daz, DaniRuiz Daz, DaniRuiz Daz, Dani
M
Brandan, Nora C.Brandan, Nora C.Brandan, Nora C.Brandan, Nora C.
mica. Facultad de
edicina. UNNE.
os, Isabel Cristinaos, Isabel Cristinaos, Isabel Cristinaos, Isabel Cristina
qumica. Facultad
edicina. UNNE.
rguez, Andrea N.rguez, Andrea N.rguez, Andrea N.rguez, Andrea N.
ra de Bioqumica.
edicina. UNNE.
el Alberto Nicols l Alberto Nicols
el Alberto Nicols l Alberto Nicols
dico. Colaborador
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5/24/2018 Tiro Ideas
2/15
V
L T (T
3) T
,
, ,
40 50 ,
. A
T4,T3.
L
, . T 2
, ,
. L ,
,
Figura 1: Glndula Tiroides. Anatom
xwt wx U||vt@Ytvtw wx `xw|v|t@ hAaAaAXA[t g||wxt @ Xw|v| ECDC
2
,
(T4). L
;
. L
60 100 %
93%
7%
. E
, (
1). E , 20
4 2 2 . P
D ,
.
E,
. E
.
A 3
, , 40
SNC.
D
(100)
C .
E ,
.
a y Localizacin
:
, .
. L ,
, ,
0
,
. E 8
,
11 12 . E
300
. J ,
,
,
,
,
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5/24/2018 Tiro Ideas
3/15
Vxwt wx U||vt@Ytvtw wx `xw|v|t@ hAaAaAXA[t g||wxt @ Xw|v| ECDC
3
L :
1) : L (
1). D 100
. L
. E
. L
. A,
. D
, ; , , ,
. E
, , ,
.
D . E 66%
, 33%
,
.
E ,
. U
. P
, 60 75 ,
20 40 .E
,
,
/ , . L
, .
E
( )
. D (/)
, NIS
+/ ( T Y).
2) : ,
660 D. P 134 18
. E 8.
L TG
. D G, ,
10% . L TG
,
G. E
150 /
90120 /
200 /
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5/24/2018 Tiro Ideas
4/15
Vxwt wx U||vt@Ytvtw wx `xw|v|t@ hAaAaAXA[t g||wxt @ Xw|v| ECDC
4
, ( ). L
TG 6 /L.C ; TG
,
. D TG , , (MIT),
(DIT), (T4) (T3)
TG,
. P
TG
100 ,
, .
3) L (10% ),
, , .
E
: TG (MIT)
(DIT). S, MIT
DIT T3 DIT T4.
E
. E TPO (H2O2)
.
4) G O
T 1 2 (TOX1 TOX2; DUOX LNOX).E
180.000 190.000 D.,
NADPH
,
. E H2O2, ,
(I+)
TPO. E NADPH
.
L
;
,
, , ,
.
E
,
. E ,
, , I/N+ NIS. E
NIS TO4, CO4 SCN. L NIS
, ,
.
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5/24/2018 Tiro Ideas
5/15
Vxwt wx U||vt@Ytvtw wx `xw|v|t@ hAaAaAXA[t g||wxt @ Xw|v| ECDC
5
E NIS , ,
SLC5A ( 2),
( ) (
). L N+/K+
(N+/K+ ATP) ( ) ( )
.
A NIS , ,
, , , ;
. A, , , NIS. E ,
.
U
: N NIS . N
NIS . P
TSH.
E
P (PDS),
,
. L PDS
73331.1, 21 780 .
A , ,
T A Y. E ,
.
C ,
, ,
TPO TOX, :
I. (I) NIS,
. E , ,
.
II. ( ) ,
PDS, .
III. ( H2O2)
(T). E
+/ +/
+/
+
+
/
+
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5/24/2018 Tiro Ideas
6/15
V
, (I+).
IV. E
. S (MIT) (DI
V. , T4 (
DIT) T3 (DIT). E
TPO.
L
L
:
Figura 2. Sntesis-Secrecin de Hormon
xwt wx U||vt@Ytvtw wx `xw|v|t@ hAaAaAXA[t g||wxt @ Xw|v| ECDC
6
(I)
TG
(TPO),
).
MIT
TG.
, ,
VI. : :
(
.
VII. : ,
D
. M
MIT, DIT, T4 T
TG. L ,
as Tiroideas
9
,
TG, ,
H
TG,
,
. E ,, MCT8
.
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5/24/2018 Tiro Ideas
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Vxwt wx U||vt@Ytvtw wx `xw|v|t@ hAaAaAXA[t g||wxt @ Xw|v| ECDC
7
L MIT DIT TG (D),
(
T4 T3),
, , . E
,
.
A TG , 10% ,
, ,
. E , ,
, . D
TG .
L T4, T3
,
T4 T3, D 1 2. ( T3)
L T3 T4 . S
: A, G
(TBG) T (TTR TBPA).
C
, , ,
( ). E
, , ,
HT . L TBG, , ,
TBG T4 T3
. L TTR
T4 .
L T4 TBG 70%, 20% TTR 10%. L T3
TBG (80%), TTR. P, T4
1 T3 , T4 (7 ) T3 ( 24 ).
L
"". S . P,
.
3
D , T4
T3, . S , T3 2
, , ,
T4 , T3.
S D
(D1, D2 D3), T4, . S
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5/24/2018 Tiro Ideas
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V
, ,,
R
. E , 1
1424.224.3; D1432.
L T3 T2. S
. S ,
,
T3. L D1
. E
(PTU).
L
T T3
, RNA
. E
T D2 (
D1). N D1.
L
T3 T3 T2,
Figura 3.
xwt wx U||vt@Ytvtw wx `xw|v|t@ hAaAaAXA[t g||wxt @ Xw|v| ECDC
8
, .
D1 233; D2
3
T4 T3,
T4 T3.
(T3) T2. S, ,
T3
. L
PTU,
T4
,
,
.
D2
L
T4. M
L
TS
10
, TSH, TG
E W C
esyodasas
. L D3 . S
,
, . P
, D3 L D3
( D1),
. L D3
PTU.
T3
. E T3 : T3
T3
,
, T3, ,
.
AUTORREGULACIN TIROIDEA
,
. E
. S
100
AMP . E
. L
, . E
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5/24/2018 Tiro Ideas
9/15
V
,
. P
W C, ,
.
L
. B ,
.
E . E
3 : . L TRH
TSH, . A ,
TRH TSH
. C ,
.
. L ,
. D ,
/ T4.
A
xwt wx U||vt@Ytvtw wx `xw|v|t@ hAaAaAXA[t g||wxt @ Xw|v| ECDC
9
. C
,
,
(TSH)
,
,
, ,
TSH,
,
T3
, TSH ;
,
TSH
,. P ,
TSH C (PKC),
E , TSH
1. A :. A
TSH . A
. A
() .
2. M Y. I . A
Figura 4. Eje Tirotro
. E
. A
A (PKA),
.
, :
. ()
.
NIS .
.
o
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5/24/2018 Tiro Ideas
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Vxwt wx U||vt@Ytvtw wx `xw|v|t@ hAaAaAXA[t g||wxt @ Xw|v| ECDC
10
. A .
. I .
3. S HT. A TG TPO.. A .. A NADPH
.. A
.
4. S HT. A TG
.. A TG
.
S , , ,
/ ,
, , ; .
P
, ,
.
L (TR) , TR
TR, 17 3, . S
TR, ,
.
A TR, 17 6
.
P , TR 1 TR 2. P TR 1,
, . P TR2
HT, T3
. S , , , ,
, ., TR.
P
ARN , TR 1
TR2, . E T3
TR2.
L TR RA,
( ). E
.
E TR : TR1, TR2, TR3 TR3.
TR1 , . L TR2
, , . E
TRH TSH. E TR3
,
.
P
,
.
S . P
,
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5/24/2018 Tiro Ideas
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V
. P ,
. M
.
E
T3, TR , (N R C) S
M R T
(HDAC),
.
I ,
(TR). E (
T3,
CBP. A
Figura 5. Mecanismo de Accin Genmico
xwt wx U||vt@Ytvtw wx `xw|v|t@ hAaAaAXA[t g||wxt @ Xw|v| ECDC
11
,
,
,
. Q
NCRRT (S
),
XR). A
,
, 300
. E
.
E (
. P
. A
ADN (NRE), ,
. O
A ,
. E
(1). A
K+, C+2 ;;
, PKA ERK/MAPK. (1,2).
E ,
P
C+2 ATP
, N+/H
, ,
)
: T3
TR
.
,
,
N+,
PKC,
,
.
N+/+ ATP, +,
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5/24/2018 Tiro Ideas
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V
K+ (I)
E
(2,3)
P
,
. Q ,
C++ ,
, , (3).
E PKA
. L
,
. L (
C+) (
P ,
. L T3
Figura 6. Mecanismo de Accin No Gen
xwt wx U||vt@Ytvtw wx `xw|v|t@ hAaAaAXA[t g||wxt @ Xw|v| ECDC
12
,
.
C+2,
).
( )
,
. L
ATP ,
E
. P
,
D
,
S
,
ico
. L 28
ADP,
K ATP
48
. E
( ).
,
,. E
.
,
.
. I
. S
,
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5/24/2018 Tiro Ideas
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Vxwt wx U||vt@Ytvtw wx `xw|v|t@ hAaAaAXA[t g||wxt @ Xw|v| ECDC
13
.
L
, , , . E T4, 60 100 % . E
, .
S . E
, , . L
,
, . L
,
,
. E
.
A , , ,
, (LDL) . D
.
D
,
.
L . L
, .
E
. S ,
, .
L ,
. E
.
L HT ,
, ,
(CK CPK)) , ,
.
L
(SHBG), . E
SHBG, .
E . E
, , . E
.
A
, .
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5/24/2018 Tiro Ideas
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Vxwt wx U||vt@Ytvtw wx `xw|v|t@ hAaAaAXA[t g||wxt @ Xw|v| ECDC
14
L . LT3
, . L
T3.
L ,
.
L TRH
; TSH
. E , T3 T4
, 2 , TBG
. E TBG
, 20 ,
TBG. L
TBG 2024 ,
. A TBG,
. D ,
( ) .
L TSH
,
(CG), TSH .E
CG TSH. P CG
TSH , . P ,
CG TSH ,
TSH ,
CG . S , CG
, TSH
, TSH. E
, T4 .
L HT SNC.E T3
. L 5 , T4
T3. L T3 . P , SNC T3 .
S HT ,
, . S HT
, . E
. S HT, ARN , ,
ADN, ,
.
L , (T4)
(T3), ,
,
.
L ,
, ,
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5/24/2018 Tiro Ideas
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Vxwt wx U||vt@Ytvtw wx `xw|v|t@ hAaAaAXA[t g||wxt @ Xw|v| ECDC
15
, .
E
(),
(), (). E ,
,
, ,
.
L , ,
. A
. E
,
, , .
K, H M. K: W T E. 11 E. E E, 2008.
G, A C., H, J E. T F M.11 E. E E, 2006.
M, P E. L E P. 2 E. TMGH C. 2006
P, M. T E P. 3 E.E MGH I.
G, W F. F M. 18 E. E EM M, 2002.
L: B' H D: A T CM, 8 . S, A I E. 2007.
P, M. A. . F E: B M D. F 6: T: B F.S M, 2005.
X C H S. N 3 . CO E & D. 2006, 13;439443.
G A. G; S H V; O R M;S A. B A G C. B P C A T E M.R M, 15 (1): 94104, 2007.
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