Tihamer Toth-Fejel General Dynamics Advanced … · Building a Nanofactory Tihamer Toth-Fejel...
Transcript of Tihamer Toth-Fejel General Dynamics Advanced … · Building a Nanofactory Tihamer Toth-Fejel...
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Building a NanofactoryTihamer Toth-Fejel
General Dynamics Advanced Information Systems [email protected]
http://www.crnano.org/conf2007.htm
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Contents
Nomenclature Approach TaxonomiesMolecular Building Blocks—The Nice and the PerfectSolid-Phase DNA Synthesis and Wang CubesTip Hyperarrays and Smart PoresPixilated DNA Origami TemplatingApplications
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Definition: Nanotechnology
Nanotechnology1. The understanding and control of matter at dimensions of
roughly 1 to 100 nanometers, where unique phenomena enable novel applications.
2. Manipulation of matter at the atomic and molecular level to develop novel devices and productive nanosystems.
Note the difference in emphasis: properties vs. machines
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Nomenclature: Nanotech TaxonomyTop-Down Bottom Up
Bottom-to-Bottom
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Nomenclature: FactorySimilarities
• Mass Production • Interchangeable parts• Input/Process/Output• Positional Assembly• Product and Process Design• Layout/Control/Test• Low cost
Differences• Size• Physical Properties• Massive Parallelism• Extreme Automation• Additive assembly vs.
Everything else
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Nomenclature: Metrology
If you can’t measure it, you can’t make it.• Accuracy • Precision• Reliability, Repeatability and Reproducibility• Traceability, calibration• Tolerance• Surface finish• Quality• Interchangeability• Statistical methods• Hierarchical AMS and ATE from molecular
level up
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Nomenclature: 3-D Printers
Nanofactory SimilaritiesGeometric freedom No tooling No wasteNo inventoryNo assemblyCustomization
DifferencesResolutionOrientationTypes of inputs
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Approach Taxonomies
How do we get there from here?• Process
• Assembling Atoms•Synthesis•Mechanosynthesis
• Assembling Nanomodules•Self-assembly•Directed Assembly
• Error Correction• Input Envelope• Output Envelope
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Mechanosynthesis
DCB6-Si dimerplacement tool tip.
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Self-Assembly
Anisotropically interacting particles and their assemblies Conventional diblock copolymer and
diblock copolymer attached to a nanocube
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Self-Replication
Kinematic Cellular Automata
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Chemical Industry 2020 Nanomaterials Roadmap: From Fundamentals to Function
Nanomaterials By DesignA "library" of nanomaterial
building blocksResearch Priorities
Nano-scale building blocksDesign strategies for controlled assembly; spatially resolved nanostructures
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Nice nanoscale building blocks
Orthogonal functionality1-10 nm diameter
Permits:nm x nm x nm Constructionnm control of periodicity in 1, 2 or 3-DMultiple types of building blocks (e.g. conducting, non-conducting, p-type, n-type)
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Silsesquioxane Nanocube core
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Silsesquioxane Nanocube
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Perfect nano building blocks
Face connection (not corner)
Controllable enantiomeric and anisomorphic functionality
Step-wise and hierarchical construction
Arbitrary 3D structuresConnection properties
independent from electrical properties
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G1 & G2 Silsesquioxane Nanocubes
Ideal G2
Ideal G1 nanocubes
More realistic G1 nanocube
Realistic G2
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More Nanocube Requirements
• Inter-cubelet and intercube links must create and preserve desirable properties
• Consistent length of links• Externally controllable connection
chemistry• Actuator Nanocubes
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Solid Phase DNA Synthesis
Step 1: De-blocking/ Deprotection
Step 2: Activation
Step 3: Base Condensation (Coupling)
Step 4: Capping
Step 5: Oxidation
Repeat
Post-Synthesis Processing
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2D Assembly Example
Given an arbitrary structure, how can complementary Wangtiles form them, and in what sequence should they be made?
Substrate
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2D Assembly Example
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Connecting Nanocubes
Pyrimidine photodimerization Diels-Alder cycloaddition
Zinc fingers
Photochemical bonding
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Molecular Actuators
Interlocking Rotaxane Dimers
AnnulenesAzobenzenePoly calix[4]arene-bithiopheneViral Protein Linear (VPL) motorsF0 and F1 motors of ATP synthaseMyosin/actinDNA motors, walkers, and tweezersPhosgene-fueled triaminotriptycene/4-
(dimethylamino)pyridine assembly
Jimenez-Molero, Dietrich-Buchecker, and Sauvage, Chemically Induced Contraction and Stretching of a Linear Rotaxane Dimer, Chem. Eur. J. 2002, 8, No. 6
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Nanocube Motors
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Tip Arrays: Atomically Precise Manufacturing
The ability to produce 3D structures with top-down control and atomic precision.
The inevitable result of continued improvements in ultra-precision manufacturing (IC manufacturing and others)
The proposed approach is an integration of known techniques and designed to produce a broadly applicable manufacturing process.
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Tip Hyperarrays
Dip Pen55,000 tipsThermally actuatedMultiple inks15 nm resolutionFast
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Smart Pores -> Smart Silkscreen
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DNA Origami: 50 billion Smiley Faces
Paul W. K. Rothemund, Folding DNA to create nanoscale shapes and patterns, Nature Vol 440,16 March 2006 Courtesy Paul Rothemund
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Easily reproducible
Qian Lulu, et al., Analogic China map constructed by DNA. Chinese Science Bulletin. Dec 2006. Vol. 51 No. 24
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The DNA Origami Process
c.d.
b.a.
Figure a,b, and d from Paul Rothemund, Design of DNA origami, IEEE/ACM International Conference on Computer-Aided Design. Nov. 2005
Figure c by Toth-Fejel
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Helper Strands
Detail from Paul W. K. Rothemund, Nature Vol 440,16 March 2006
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Helper Strands for Pixilated Origami
Labeled Helper Strand (bit=1)Regular Helper Strand (bit=0)
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Pixelated DNA Origami
courtesy Paul W. K. Rothemund
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Pixelated DNA Origami
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DNA Internal Labeling
Amino-Modifier C6 dA
Glenn Research http://www.glenres.com/
Amino-Modifier C6 dG
Amino-Modifier C6 dT
Amino-Modifier C6 dC
Biotin-dT
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DNA-mediated Nanocube Assembly
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DNA-mediated Multi-layered Nanocube Assembly
P-type or
N-typeSemiconductor
Insulator
Conductor
Patent Pending
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NAND
•Not inherently limited to 2D
•Features ~ Bohr exitonradius
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Hierarchical Assembly
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Hierarchical Assembly: Polyominoes
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Design-ahead: NanoEngineer-1
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Applications
Product DesirementsLow cost High performanceHigh value
Nanostructure Manufacturing CapabilitiesArbitrarily complex HeterogeneousMolecular precisionLong-range orderBulk quantities
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Pore nanocubes
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PEM Fuel Cells
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Extreme Broadband Reconfigurable Fragmented Aperture Phased Arrays
UV to Radio WavelengthsHigh efficiencyConformal and flexible
Pringle, et al. A Reconfigurable Aperture Antenna Based on Switched Links Between Electrically Small Metallic Patches. IEEE Trans Antennas & Propagation, V52N6, June 2004
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Negative Index of Refraction MetamaterialsPerfect lens with sub-wavelength resolutionUnusual nanophotonicdevicesOptical Cloaking/Camouflage
D. Schurig, et al. Metamaterial Electromagnetic Cloak at Microwave Frequencies Science 314, 977 (2006);
Smolyaninov, et al., Magnifying Superlens in the Visible Frequency Range. Science 315, 1699-1701 (2007)
Inami, et al., Optical Camouflage Using Retro-Reflective Projection Technology ISMAR 2003
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Desktop Nanofactory Appliance
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Molecular Printers, the Tragedy of Commons, Orwell, and Owning Air
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Conclusion
Nanofactories are a tipping point in the industrial revolutionThere are many approachesComing soon to your neighborhood