TIBCO Spotfire for Discovery Research - chemaxon.com · TIBCO Spotfire for Discovery Research ......
Transcript of TIBCO Spotfire for Discovery Research - chemaxon.com · TIBCO Spotfire for Discovery Research ......
© 2008 TIBCO Software Inc. All Rights Reserved. Confidential and Proprietary.
TIBCO Spotfire for Discovery Research
How Visual Analysis Can Accelerate Insights
September 2011
http://spotfire.tibco.com/spotfire-for-you/by-industry/life-sciences/lead-discovery.aspx
© 2006 TIBCO Software Inc. All Rights Reserved. Confidential and Proprietary. 2 © 2005 TIBCO Software Inc. All Rights Reserved. Confidential and Proprietary. 2 © 2008 TIBCO Software Inc. All Rights Reserved. Confidential and Proprietary.
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What is Spotfire?
Unique interactive visual
analytics to spot trends, outliers
and other hidden relationships in
data
Applicable to many different
types of data
Easily accesses data from
multiple, disparate sources
(Oracle, Excel, SAP, etc.)
Helps deploy best practices
Extensible platform with an open
SDK
© 2006 TIBCO Software Inc. All Rights Reserved. Confidential and Proprietary. 3 © 2005 TIBCO Software Inc. All Rights Reserved. Confidential and Proprietary. 3 © 2008 TIBCO Software Inc. All Rights Reserved. Confidential and Proprietary.
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Validation HTS
Lead
Optimization ADME Toxicology Clinical Manufact
Spotfire Across the Pharma Enterprise
PV
One user experience for analytics - Unified data retrieval - Configurable
to any business process
Sales &
Marketing
Proteomics
Systems
Biology
Biomarker Research
Pharmacokinetics
Compound
Profiling
Pharmacology
Biostatistics
Exploratory
Development
Toxicology.
Animal Studies
Screening
Safety and Risk Mgmt
Portfolio Assessment
Competitive
Efficacy
Physician Targeting
Segmentation
Gene
Expression,
Bioinformatics
Adverse Events
Data Monitoring
Call Planning
Sales Force
Effectiveness
Hit Selection
Combinatorial Chemistry
Computational Chemistry
Clinical Pathology
Biostatistics
© 2006 TIBCO Software Inc. All Rights Reserved. Confidential and Proprietary. 4 © 2005 TIBCO Software Inc. All Rights Reserved. Confidential and Proprietary. 4 © 2008 TIBCO Software Inc. All Rights Reserved. Confidential and Proprietary.
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Spotfire Integration with ChemAxon
JChem Cartridge
Spotfire Server
MarvinView
Spotfire Client
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TIBCO Spotfire: One Platform, Many Applications
HCS, HTS Project KPIs
SAR Competitive Intelligence Gene Expression
Kinase Inhibitors
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Chemistry Project Dashboard
For: Team Leaders, Project Managers, Scientific Management
How is my project doing vs. goals?
Which series looks most promising?
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SAR
For: Medicinal Chemists, Computational Chemists, Biologists
Are there trends? Outliers?
What’s the structural basis for observed activity?
What should I make next?
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Selectivity Analysis
For: Screening Biologists, Lead Chemists
How do my compounds behave across targets?
Which compounds are selective, and why?
Which compounds should advance?
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Dose Response
For: Screening Biologists, Team Chemists
How do my lead compounds behave in different assays?
How do my lead compounds compare to a reference compound?
How reliable are my IC50 values?
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High Throughput Screening
For: Screening Biologists, Team Chemists, Team Biologists
How do I detect systematic quality issues?
How do I identify hits?
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Competitive Analysis
For: Researchers, Managers
Where is my company strong and weak?
What therapeutic areas, diseases, mechanisms are best to
target?