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Transcript of Thudichum Medal Lecture - Biochemical Society · PDF fileThudichum Medal Lecture ... R. 1. H....
London: The Biochemical Society 0 I995 Executive Editor: Keith Snell Staff Editor: Kim Benson
Thudichum Medal Lecture
The Acetylcholine Receptor: A Model for Allosteric Membrane Proteins 1.-P, CHANGEUX
Colworth Medal Lecture
Molecules Mediating Signals L. STEVENS
Royal
Ultraviolet in DNA
Irish Academy Medal Lecture
Radiation Damage
colloquia
653rd Meeting Sussex
I95
107
R. 1. H. DAVIES 407
colloquium: Plant Peroxidases, Structure and Molecular Biology
Structural determinants of the catalytic activities of peroxidases
The crystal structure of ascorbate and manganese peroxidases: the role of non-haem metal in the catalytic mechanism
Aromatic donor molecule binding sites of haem peroxidases
The functional role of the key residues in the active site of peroxidases
Gene structures of peroxidase isoenzymes in horseradish and Arabidopsis thaliana and their expression
Expression of horseradish peroxidase in transgenic tobacco
Homology modelling of horseradish peroxidase coupled to two-dimensional NMR spectral assignments
P. R. ORTIZ DE MONTELLANO, S.4. OZAKI, S. L. NEWMYER, V. P. MILLER AND C. HARTMANN
T. L. POULOS, W. R. PAITERSON AND
M. SUNDARAMCCIRTHY
N. C. VEITCH
G. SMULEVICH
K. FUJIYAMA, C. INTAPRUK AND A. SHINMYO
A. PELLEGRINEXHI, M. KIS, I. Dix, T. A. KAVANAGH AND
P. J. Dix
G. H. Low, P. Du AND A. T. SMITH
113
iia
131
140
145
147
150
Volume 23 Part 2 May 1995
n 0 3 r) 0 3 rr VI
I -1
Z P n -1
z
F m
5 m
Functions of electrostatic potentials and conserved distal and proximal His-Asp H-bonding networks in haem peroxidases
Radical cation cofactors in lignin peroxidase catalysis
Vanadium chloroperoxidases occur widely in nature
Characterization of a novel non-haem-containing extracellular peroxidase from Thermomonorpora fusca
K. G. WELINDER, 6. BJ0RNHoLM AND H. 6. DUNFORD 257
P. J. HARVEY AND L. P. CANDEIAS 262
E. G. M. VOLLENBROEK, L. H. SIMONS, J. W. P. M. VAN SCHIJNDEL, P. BARNETT, M. BALZAR, H. DEKKER, C. VAN DER LINDEN AND R. WEVER
A. S. BALL AND C. TRIGO
267
272
colloquium: Lipids in Immune Function and Inflammatory Disorders
Chairman’s Introductory Remarks
n - 3 Polyunsaturated fatty acids in the regulation of human cytokine synthesis
Modulatory influence of unsaturated fatty acids on the biology of tumour necrosis factor-a
Suppression of autoimmune disease by a, - 3 fatty acids
Fatty acid modulation of cell responsiveness
Arachidonic acid in the reticuloendothelial network
Fatty acids, dietary lipids and lymphocyte functions
K. W. J. WAHLE
S. ENDRES, T. EISENHUT AND B. SINHA
277
277
R. F. GRIMBLE AND P. S. TAPPIA 282
D. R. ROBINSON, C. T. KNOELL, M. URAKAZE, R. HUANG, 287 H. TAKI, E. SUGIYAMA, L.-L. Xu, E. T. H. YEH, W. OLESIAK, M. Guo, R. B. COLVIN AND P. E. AURON
D. ROTONDO 29 I
H. A. LEAVER, J. R. WILLIAMS, I. M. DAWN AND 297 P.-L. YAP
P. C. CALMR 302
~~~
colloquium: Regulation of Carbohydrate Metabolism in Muscle and Liver
Regulation of glucose metabolism in cardiac muscle
Mechanisms underlying suppression of glucose oxidation in insulin-resistant states
The mitochondria1 carnitine palmitoyltransferase system: its broadening role in fuel homoeostasis and new insights into its molecular features
Amylin regulation of carbohydrate metabolism
Adult glucose and lipid metabolism may be programmed during fetal life
Paracrine/autocrine control of the islet and the amylin family
L. HUE, C. DEPRE, V. LEFEBVRE, M. H. RIDER AND
K. VEITCH
M. C. SUGDEN AND M. J. HOLNESS
31 I
314
J. D. MCGARRY 32 I
A. YOUNG, R. PITTNER, B. GEDULIN, W. VINE AND
T. RINK
M. DESAI, N. J. CROWTHER, S. E. OZANNE, A. LKAS AND C. N. HALES
D. M. SMITH AND S. R. B L ~
325
331
336
colloquium: The Control of Flux: 21 Years On
n 0 J ft
The control of flux
Molecular biology for flux control
Control analysis of energy metabolism in mitochondria
Probing the properties of enzymes in vivo using NMR
Two paradigms of metabolic engineering applied to amino acid biosynthesis
Recent developments beyond Metabolic Control Analysis
H. KACSER, J. A. BURNS AND D. A. FELL
P. R. JENSEN, J. L. SNOEP, D. MOLENAAR, W. C. VAN HEESWIJK, B. N. KHOLODENKO, A. A. VAN DER GUGTEN A ~ D H. V. WESTERHOFF
M. D. BRAND AND A. KESSELER
34 I
367
37 I
K. BRINDLE, 5. FULTON, J. SHELEON AND S. WILLIAMS 376
T. W. SIMPSON, G. E. C O L ~ N AND G. STEPHANOPOULOS 38 I
H. KACSER 387
colloquium: Molecular Liaisons
Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: 'designer' changes in V,,,,,., stability and membrane association
Models of human disease through gene targeting
M.D. HOUSLAY, G. SCOTLAND, L. POOLEY, S. SPENCE, I. WILKINSON, F. MCCALLUM, P. JULIEN, N. G. RENA, A. M. MICHIE, S. ERDOGAN, L. ZENG, J. C. O'CONNELL, E. S. TOBIAS AND I . MACPHEE
393
R. C. MOORE AND D. W. MELTON 398
Transforming growth factor-8 and the protection from cardiovascular injury hypothesis
J. C. METCALFE AND D. J. GRAINGER 403
colloquium: Environmental Biochemistry
Drug metabolizing enzymes of mussels as bioindicators of chemical pollution
The glutathione S-transferase multigene family: a paradigm for xenobiotic interactions
Peroxisome proliferation in response to xenobiotics
Might environmental factors contribute to neurodegenerative diseases?
Detection of micro-organisms in the environment
D. SHEEHAN, J. MC~NTOSH, A. POWER AND
P. J. FITZPATRICK
T. J. MANTLE
J. W. DEPIERRE, A.-K. SOHLENIUS, Y. CAI, A. MESSING ERIKSSON. K. ANDERSSON AND c. SUNDbERG
K. F. TIPTON
R. POWELL, M. MULL-ARKEY, D. O'BRIEN AND
J. 0. MC~NERNEY
419
423
425
429
435
(D
I
0" 3 r ) 0 3 r ) v)
I
Plant peroxidases, structure and molecular biology
Magnetic circular dichroism studies on Vaccinium myrtillus cationic peroxidases
lonically-bound and covalently-bound wall peroxidases differ in their substrate specificity
N. S. MELO, P. S. FEVEREIRO AND E. LARSEN I495
G. J. MCDOUGALL AND I. M. MORRISON 150s
A structural model of the alternative oxidase of plant A. L. MOORE, A. L. UMBACH AND J. N. SIEMW 151s mitochondria
Progress in the characterization of catalase-peroxidase from Mycobacterium tuberculosis
j. M. NAGY, A. E. G. CASS AND K. A. BROWN 152s
Electron transfer between cytochrome c peroxidase and ferrocene
S. J. SADEGHI AND A. E. G. CASS I535
Purification and partial characterization of 'extensin peroxidase' M. D. BROWNLEADER
N. AHMED, M. CHAPLIN, M. TREVAN, P. M. DEY AND 1545
Photosynthesis
reversible addition of 2-nitrobenzyl groups
Studies on photocleavable nitrobenzyl-bovine serum albumin conjugates
CO flash photolysis of cytochrome bd from Azobacter vinelandii
The modulation of Protein A-lgG(Fc) binding by the S. THOMPSON, M.-C. FAWCETT, J. A. SPOORS AND 155s C. H. SELF
C. H. SELF, M.-C. FAWCETT, J, A. SPOORS, L. B. PULMAN AND S. THOMEON
S. JUNEMANN, P. R. RICH AND J. M. WRIGGLESWORTH
156s
I575
Glvcobiolonv of inflammation
Appearance of lymphocytes positive for E-selectin ligands during inflammatory reactions in vivo
The L-selectin counter-receptor in porcine lymph nodes
Endothelial selectin expression and leukocyte trafficking in cutaneous DNFB-induced delayed hypersensitivity
The kinetics of E-selectin expression and leukocyte traffic in BCG/PPD delayed hypersensitivity in the pig
Adhesion of eosinophils to E- & P-selectin
Oligosaccharides of IgG in rheumatoid arthritis
The influence of cytokines on the glycosylation pattern of a- I -acid glycoprotein secreted by the HepG2 cell line
Tissue specific expression of the human a( 1-3) fucosyltransferase gene family
Chemical modification of a( 1-3) fucosyltransferase defines residues of caalytic importance
Activation of complement by DMSO and ethanol and i t s inhibition by soluble complement receptor type I
S. T. WOOLLEY, A. WHYTE, S. T. LICENCE, M. K. ROBINSON, D. 0. HASKARD AND R. M. BINNS
A. WHYTE, P. WOODING, N. NAYEEM, S. R. WATSON, S. D. ROSEN AND R. M. BINNS
A. WHYTE, S. T. LICENCE, S. T. WOOLLEY, A. A. HARRISON, D. 0. HASKARD AND R. M. BINNS
A. A. HARRISON, A. WHYTE, S. T. LICENCE, S. T. WOOLLEY, R. M. BINNS AND D. 0. HASKARD
R. PRIEST, S. NAWAZ, P. M. GREEN AND M. I. BIRD
A. J. MACGILLIVRAY, M. IWOBI, L. FERNANDES AND
G. PAPASAWAS
H. G. ELLIOTT, M. A. ELLIOTT, J. WATSON AND
K. D. SMITH
A. WINDER, N. SMITHERS, S. WITHAM, A. SYMONS AND M. EDBROOKE
C. BRITEN, C. HOOD AND M. BIRD
A. J. LAVER, M. HIBBS AND R. A. G. SMITH
158s
159s
160s
161s
162s
163s
164s
165s
I665
167s
An improved multiwell immunoassay using digoxigenin- labelled lectins to study the glycosylation of purified glycoproteins
M. T. GOODARZI, M. RAFIQ AND G. TURNER 168s
Molecular mechanisms of signalling by tyrosine kinases
lnositol I ,2,3-trisphosphate is a product of InsP, dephosphorylation in WRK- I rat mammary epithelial cells and exhibits transient concentration changes the cell cycle
Contrasting mechanisms of intracellular calcium ([Ca2+Ii) elevation by angiotensin II (All) and platelet derived growth factor-BB (PDGF-BB) in human vascular smooth muscle cells (VSMCs)
AIF,- inhibits influx of Ca2+ into vascular smooth muscle cells
Correlation of heparin binding with responsiveness in human vascular smooth muscle cells
Differential mitogenic effects of PDGF isoforms and heparin on human vascular smooth muscle cells
Signalling at the epidermal growth factor receptor: role of glycosyl-phosphatidylinositol hydrolysis
Cyclic AMP modulates adipogenesis in 3T3-F442A cells
Critical role for the phosphorylation of tyrosines 674 and 675 in signalling by the Trk tyrosine kinase
Developmental protein expression in thermally stressed Pisum sativum plants
lmmunochemical characterization of mitochondria1 proteins isolated from Pisum sativum, subjected t o thermal stress and age development
The role of phosphatidylinositol 3-kinase activity in insulin-stimulated mitogenesis in 3T3-L I adipocytes
Purification of an insulin-stimulated acetyl-CoA carboxylase kinase from rat epididymal adipose tissue
Inhibition of Xenopus laevis poly (ADP-ribose) polymerase in oocytes
Cytokine-induced E-selectin expression by human umbilical vein endothelial cells (HUVEC). A role for protein tyrosine kinases?
Effect of phorbol esters on phosphatidylinositol 3-kinase activity in adipocytes
Differential modulation of apical and basolateral endocytosis in Caco-2 cells
lntracellular mediators of insulin-like growth factor I during otic vesicle development
C. J. BARKER, J. WRIGHT, C. J. KIRK AND R. H. MICHELL 1695
G. F. CLUNN, M. SCHACHTER AND A. D. HUGHES
A. D. HUGHES AND M. SCHACHTER
J. 8. REFSON, M. SCHACHTER, M. K. PATEL, P. CHAN, J. H. N. WOLFE AND P. SEVER
J. 8. REFSON, M. ~ H A C H T E R , M. K. PATEL, J. H. N. WOLFE AND P. SEVER
D. R. JONES, R. CLEMENTE AND I. VARELA-NIETO
8. J. YARWOOD, N. G. ANDERSON AND E. KILGOUR
M. GUITON, F. J. GUNN-MOORE AND J. M. TAVARE
C. K. WOOD, J. R. PRATT AND A. L. MOORE
J. R. PRATT, C. K. WOODANDA. L. MOORE
R. J. HAIGH, P. R. SHEPHERD, B. T. NAVE AND K. SIDDLE
K. J. HEESOM, 8. K. MOULE AND R. M. DENTON
S. AOUFOUCHI AND 8. SHALL
M. J. MAY, C. P. D. WHEELER-JONES AND J. D. PEARSON
B. T. NAVE, P. R. SHEPHERD AND K. S~DDLE
W. SHURETY AND J. P. Luzio
Y. LEON, C. SANZ AND I. VARELA-NIETO
170s
1715
1725
I735
174s
I755
I765
177s
I785
I795
180s
1815
182s
1835
184s
185s
Construction and expression of a functional chimeric receptor from PDGFr-B and c-erbB-2
Effects of myristoylated pseudosubstrate protein kinase C peptide inhibitors on insulin secretion
Comparative phosphorylation kinetics of the human insulin receptor protein-tyrosine domain and an enzymatically competent deletion construct - the tail could wag the dog
Calcium oscillations and waves during IgE receptor crosslin king
Possible role for PI3 kinase but not ~ 7 0 ~ ~ ~ in regulation of lipogenesis by insulin and growth hormone in sheep adipose tissue
Micro-injection of p2 I ras into Xenopus oocytes, o r incubation of oocyte S- I00 with ATP, induces the activation of elF-4a kinase(s)
A basic residue C-terminal to tyrosine compromises its viability as a tyrosine kinase target
P2 I -ras is involved in regulation of voltage-dependent calcium channels in cultured rat dorsal root ganglion cells
Stimulation of platelets with platelet-activating factor induces changes in the subcellular distribution and activity of the tyrosine kinase pp6OC-"'
V-Ras activates phosphatidylinositol 3-kinase
Role of c-lyn in the functional effects of GM-CSF on human neutrophils
Differential effects of wortmannin on growth hormone dependent signalling pathways in 3T3-F442A cells
Phosphatidic acid phosphohydrolase in guinea-pig airway smooth muscle
Phospholipase D regulation involves extracellular calcium as a conditional requirement for subsequent stimulation by protein kinase C
PKC-dependent activation of the type II adenylate cyclase in airway smooth muscle limits the bradykinin- stimulated ERK-2 pathway
Involvement of PI 3-kinase in stimulation of glucose transport and recruitment of transferrin receptors in 3T3-L I adipocytes
Insulin activates glycogen synthase by a novel PI 3-kina~e/p70"~ dependent pathway in 3T3-L I adipocytes
Thrombin and histamine phosphorylate the 42 kDa mitogen-activated protein kinase in HUVEC
I. J. UINGS, G. D. SPACEY AND R. W. BONSER 186s
T. E. HARRIS, S. J. PERSAUD, T. SAERMARK AND
P. M. JONES
P. G. QUIRK, N. E. KEANE, B. A. LEVINE, L. WEI AND
L. ELLIS
187s
188s
B. HAYES, A. CROFTS AND K. RAY 189s
R. G. VERNON AND S. LINDSAY-WA~ 190s
S. J. MORLEY AND V. M. PAIN 191s
N. E. KEANE, P. G. QUIRK, B. A. LEVINE, A. CHAVANIEU, 192s B. CALAS, Y. GAO, L. WEI AND L. ELLIS
E. M. FITZGERALD AND A. C. DOLPHIN 193s
C. T. MURPHY AND J. WESTWICK 194s
T. KODAKI, R. W~XHOLSKI AND P. J. PARKER 195s
N. T. THOMPSON, R. W. RANDALL AND L. G. GARLAND 196s
N. G. ANDERSON AND E. KILGOUR 197s
D. G. TOLAN, N. J. PYNE AND S. PYNE 198s
S. PYNE AND N. J. PYNE 199s
N. J. PYNE, P. STEVENS, N. MOUGHAL AND S. PYNE 200s
P. R. SHEPHERD, B. T. NAVE AND K. SIDDLE 201s
P. R. SHEPHERD, B. T. NAVE AND K. SIDDLE 202s
C. P. D. WHEELER-JONES AND J. D. PEARSON 203s
Phosphatase inhibitors potentiate the release of vasoactive mediators from human endothelium
Effects of myristoylated pseudosubstrate inhibitor of PKC in intact human platelets
Studies with wortmannin indicate that insulin stimulation of lipogenesis involves multiple signalling pathways
Cloning of a chicken gene homologous to the rabbit mono-ADP-ribosyltransferase gene
The regulation of phospholipase C (PLC) and phospholipase D (PLD) by G protein receptor- activated tyrosine kinases in aT3- I cells
Characterization of a novel '22kDa' phosphoprotein which may be important in insulin action
The effect of tyrosin kinase inhibition on phorbol 12.13-dibutyrate- and ionomycin-induced LH and GH release
C. P. D. WHEELER-JONES, R. A. HOULISTON, A. J. MORGAN AND J. D. PEARSON
C. P. D. WHEELER-JONES, S. SAVED AND
S. J. PEFSAUD
S. K. MOULE, N. J. EDGELL, G. I. WELSH, T. A. DIGGLE, C. G. PROUD AND R. M. DENTON
204s
205s
2065
T. DAVIS AND S. SHALL 207s
R. MITCHELL, W. B. WOLBEFS, P. SIM AND
M. FENNELL 208s
T. A. DIGGLE AN[
M. S. JOHNSON, J. R. MITCHELL
R. M. DENTON 209s
~OBLE, W. B. WOLBEFS AND 210s
Biochemical immunology group
antigen 19-9 and carbohydrate antigen I25 in carcinoma of the lung
Serum levels of neuron-specific enolase, carbohydrate G. OKTAY, G. GUNER, C. KARLIKAYA AND
A. AKKKLU
A. GUNER, G. OKTAY, M. KERMAN AND G. GUNER
21 I S
Immunoglobulins and a- I -proteinase inhibitor in 212s human intervertebral disc material
Iron, desferrioxamine, and ATP interactions in proliferating lymphocytes and B-cell lines
Apoptosis in T and B lymphocyte's life cycles
G. 0. LATUNDE-DADA AND S. P. YOUNG 213s
C. G. H. BELL 214s
Heat shock protein (Hsp)65-70: dominant self-antigen candidate in the selection of yd lymphocytes?
B-cell repertoire selection: fine specificity of antibodies elicited by bacterial polysaccharide dextrans and by V-region reactive ligands
C. G. H. BELL
C. G. H. BELL
2155
2165
Hormone Prow
High concentrations of B-adrenergic agonists inhibit DNA binding of glucocorticoids in human lung in vitro
Measurement of insulin secretion from single pancreatic assay
Characterization of a variant of ovine growth hormone (oGH I158A) produced by site-directed mutagenesis
Preparation and characterization of recombinant DNA-derived ovine growth hormone variants in which the C-terminal disulphide bridge is modified
The mitogen-activated protein kinase cascade in rat islets of Langerhans
cells using a reverse haemolytic plaque
I. M. ADCOCK, M. J. PETERS, C. R. BROWN, D. A. STEVENS AND P. J. BARNES
H. RATCLIFF AND P. M. JONES
217s
218s
A. LIOUPIS, 0. C. WALLIS AND M. WALLIS 219s
R. E. GILES, 0. C. WALLIS AND M. WALLIS 220s
S. J. PEFSAUD, C. P. D. WHEELER-JONES AND P. M. JONES 221s
n 0 3
3 (3 VI
0 I 8 3 3 i5' R i5'
C 3
.II
3t
Membrane group
Effects of ion concentration gradients on glycine transport and accumulation
L. C. WARREN AND K. P. WHEELER 222s
Molecular and cellular pharmacology group
The involvement of inositol lipids and phosphates in signalling in the fission yeast Schizosocchorornyces pornbe
Antioxidant status in hypertension and effects of angiotensin converting enzyme inhibition
J. A. STUART, P. j. HUGHES, C. J. KIRK, j. DAVEY AND
R. H. MITCHELL 223s
H. J. F. WHY, H. ANSELL, V. B. PATEL, W. S. WASSIF, j. REEVES, T. SIDDIQ, P. J. RICHARDSON AND
V. R. PREEDY
224s
Naphthoquinone-induced DNA damage in the absence of oxidative stress
W. A. MORGAN 225s
Neurochemical group
Nerve growth factor regulation of a late response gene - neuropeptide Y
Alanine reverses the inhibitory effect of phenylalanine and i ts metabolites on Na*,K+-ATPase in synaptic plasma membanes from cerebral cortex of rats
formation from labeled substrates by rat cerebral cortex
Inhibition of citrate oxidation in vim by 2-hydroxybutyrate and 4-hydroxybutyrate in cerebral cortex of young rats
N. HOLLIDAY, D. BALBI, A. PANCE AND J. M. ALLEN
A. T. S. WYSE, M. WAJNER, A. BRUSQUE AND
C. M. D. WANNMACHER
226s
227s
2-Hydroxybutyrate and 4-hydroxybutyrate inhibit CO, C. S. DUTRA-FILHO, M. WAJNER, C. M. D. WANNMACHER, E. GASSEN, R. H. CANDIAGO, A. M. WILHELMS AND H. F. C. DE MALFUSSI
C. S. DUTRA-FILHO, M. WAJNER, C. M. D. WANNMACHER, E. GASSEN, R. H. CANDIAGO, A. M. WILHELMS AND H. F. C. DE MALFUSI
220s
229s
Free radicals and oxidative stress - environment, drunr and food additives
Mechanisms of free-radical scavenging by the nutritional antioxidant B-carotene
Effect of superoxide dismutase on nitric oxide production by RAW264 macrophages
E.p.r. studies on reduced rat liver mitochondria incubated with nitric oxide
Nitric oxide production, alveolar macrophages and type II alveolar epithelial cells in response to LPS in vivo and in v i m
Changes in the catalytic properties of benzylamine oxidase
Cigarette smoke, glutathione metabolism and epithelial permeability in rat lungs
Muscle damage revisited: does tamoxifen protect by membrane stabilization or radical scavenging rather then via the E2-receptor?
Modification of aromatic amino acids by reactive nitrogen species
S. A. EVERETT, S. C. KUNDU, S. MADDIXAND R. L. WILWN
S. P. FRICKER, E. SLADE AND N. A. POWELL
230s
231s
M. P. LINHARES AND R. CAMMACK 232s
X. LI, K. DONALDSON AND W. MACNEE 233s
I. J. SILVA, M. S. AZEVEDO AND C. F. MANSO 234s
I. RAHMAN, X. Y. LI, K. D~NALDSON AND W. MACNEE 235s
P. D. R. BAR, R. W. KOOT AND G. H. J. AMELINK 2365
A. VAN DER VLIET, J. P. EISERICH, 6. HALLIWELL AND
c. E. CROSS 2375
Interactions of diesel engine emissions with extracellular biological fluids
Role of oxidants in TNF-a-mediated cytotoxicity
Fructation induced cross-linking of /?-lactoglobulin and lysozyme
Molecular mechanisms of chromium toxicity: oxidation of hemoglobin
The role of thiols in oxidation of low-density lipoprotein by macrophages
The use of LDL-resembling particle (LDL-r) as a model for the investigation of the effect of oxidation on the behaviour of LDL
A study of the effects of complexation of heme by hemopexin upon its reactions with organic peroxides
Effect of a very low fat diet on lipid peroxidation indices
Effect of a high fat meal on lipid peroxidation products
Dietary linoleic acid in alcohol-induced liver cirrhosis
Detection of intermediates formed on reaction of hyaluronic acid and related materials with the hydroxyl radical
The action of iron on amino acid and protein peroxides
The pro-oxidant activity of aminoguanidine and protein glycation
Structural modulation of lipid peroxidation by the proteins within membranes: model protein studies with liposomes
The interaction of carotenoids with reactive oxy-species
Release of the antioxidant, ferulic acid, from plant material by specific esterases
Evaluation of the antioxidant properties of food extracts
Influence of the SOD-mimetic complex Cu-PuPy on cellular redox systems, adenylates, and cell survival
Mechanism of inhibition of microsomal lipid peroxidation by estrogens: possible interactions with the cytochrome P450-dependent monooxygenase system
Antioxidants and the prevention of cataract
J. P. EISERICH, A. VAN DER VLIET, B. HALLIWELL AND
c. E. CROSS
V. B. O'DONNELL AND A. Azzi
J. LIGGINS AND A. J. FURTH
M. C. ALPOIM, C. F. GERALDES, C. R. OLIVEIRA AND
M. C. LIMA
J. L. WOOD AND A. GRAHAM
K. R. BRUCKDORFER AND C. ETELAIE
G. S. TIMMINS, M. J. DAVIES AND U. MULLER-EBERHARD
C. H. BOLTON, J, F. DWIGHT, T. M. LEVY, V. J. PARFITT AND M. HARTOG
C. H. BOLTON, K. STEER, V. J. PARFITT, M. I. HOPTON AND M. HARTOG
J. M. BAILEY, G. FISKUM, A. N. MAKHEJA AND
J. Y. VANDERHOEK
C. L. HAWKINS AND M. J. DAVIES
S. GEBICKI, G. BARTOSZ AND J. M. GEBICKI
J. V. HUNT, A. G. Mcbv AND J. T. SKAMARAUSW
A. RIEDL, M. ANDERTON. Z. SHAMSI, P. GOLDFARB AND
A. WISEMAN
T. G. TRUSCOT, D. MCGARVEY, C. LAMBERT, T. HILL, J. TINKLER, P. CONN, F. BOHM, E. J. LAND AND
W. SCHALCH
C. B. FAULDS AND G. WILLIAMSON
G. W. PLUMB, S. J. CHAMBERS, N. LAMBERT, S. WANIGATUNGA, G. R. FENWICK AND
G. WILLIAMSON
A. NAGELE
M. B. RUIZ-LARREA, A. LEAL, R. MARTINEZ, C. MARTIN AND M. LACORT
2385
2395
240s
241s
2425
2435
244s
245s
246s
2475
2485
249s
250s
251s
2s2s
253s
254s
255s
256s
W. R. MCLAUCHLAN, J. SANDERSON AND G. WILLIAMSON 257s
3 r )
3 r ) ul I
Free-radical mediated toxicity in whole rat brain reaggregate cultures is prevented by a-tocopherol
Damage to DNA and RNA by tumour promoter- derived alkoxyl radicals: an EPR spin trapping study
Investigations of a series of novel cationic photosensitisers and their potential use in photodynamic therapy
Detection of protein radicals formed by the photodynamic action of porphyrin sensitizers
Amplification of oxidative stress by decarboxylation: a new strategy in anti-tumour drug design
Oxidative stress in the plant tissue culture environment
ATP: a hitherto unrecognised, iron-specific membrane antioxidant
Differential inhibition of DNA synthesis by paracetamol in the rat testis and GI tract
Molecular liaisons
R. M. Fox, J. DAVENPORT JONES AND C. K. ATTERWILL
C. HAZLEWCOD AND M. J. DAVIES
S. M. BURROW, S. GUINOT, M. WAINWRIGHT, 1.1. WARING AND D. A. PHOENIX
J. A. SILVESTER, G. S. TIMMINS AND M. J. DAVIES
L. P. CANDEIAS, L. K. FOLKES AND P. WARDMAN
L. ROBERTSON, W. J. MAGILL, E. E. BENKIN, D. H. BREMNER AND T. E. J. BUULTJENS
T. HALLINAN, D. KUNDU AND J. GOR
C. LISTER AND A. MCLEAN
258s
2595
260s
261s
262s
2635
264s
265s
Cloning and over-expression of the structural gene encoding isocitrate dehydrogenase from Klebsiella pneumoniae
Functional characterisation of an ovine oxytocin signal transduction pathway in oxytocin receptor cDNA transfected Cos 7 cells
Analysis of a novel A-kinase anchoring protein 100, (AKAP 100)
Exogenous CD59 incorporated into U937 cells through i t s glycosyl phosphatidylinositol anchor becomes associated with signalling molecules in a time dependent manner
The human A3 adenosine receptor gene
Interferon-tau activates protein kinase C in Madin Darby bovine kidney cells
C. A. INCHE, D. J. PLATT, H. KACSER, S. A. COWAN C. F. A. BRYCE AND E. M. T. EL-MANSI
2665
P. R. RILEY, H. j. STEWART, R. E. ABAYASEKARA AND
A. P. F. FLINT 267s
S. MCCARTNEY, B. M. LITTLE AND J. D. SCOTT 2685
C. W. VAN DEN BERG, T. CINEK, M. B. HALLETT, V. HOREJSI AND B. P. MORGAN
269s
E. MURRISON, S. J. GOODSON, C. A. HARRIS AND
M. R. EDBROOKE
R. E. ABAYASEKARA, M.-J. SEARLE AND A. P. F. FLINT
270s
27 I S
b ids in immune function and indammatow disorders
The effect of dietary lipid manipulation on macrophage cell surface molecule expression
Dietary lipid modulation of cell mediated immunity in the rat
Systemic sclerosis, plasma antioxidants and lipids
Synthesis of ph~sphatidyl[~H]butanol molecular species by phospholipase D in HL60 granulocytes
Substrate selectivity of phospholipase D in HL60 granulocytes: effects of fatty acid supplementation
E. J. SHERRINGTON, P. SANDERSON AND P. C. CALDER 272s
P. SANDERSON, P. YAWB AND P. C. CALDER 273s
T. D. BUNCE, C. M. BLACK AND K. R. BRUCKCORFER
Y. M. M. HEUNG AND A. D. PSTLE
274s
275s
Y. M. M. HEUNG AND A. D. PSTLE 276s
Effects of high levels of dietary oils on autoimmune responses
Apo C subclasses from non-insulin-dependent diabetic patients - a quantitative comparison with control subjects
The effect of dietary lipid manipulation on the production of murine T-cell derived cytokines
The effects of dietary lipid manipulation upon the production of reactive oxygen species by murine peritoneal macrophages
Spontaneous hyperlipoproteinaemia in the Arabian dromedary
The phosphoinositide 3-kinase inhibitor wortmannin inhibits CD28-mediated T cell co-stimulation
A role for phosphoinositide 3-kinase in RANTES induced chemotaxis of T lymphocytes
Comparison of the lipolysis of chylomicron remnants derived from corn oil or olive oil by hepatic lipase in vitro
Depolarising levels of KCI inhibit endothelin- I -mediated release of arachidonic acid in rat C6 glioma cells
The effect of cytokines on tissue factor expression in HL-60 and U937 cell lines
H. A. C. ATKINSON AND J. MAISEY
S. VENKATESAN, H. IMRIE, S. READ AND D. HALLIDAY
P. YAWS AND P. C. CALDER
P. C. CALDER
M. P. T. GILLET, M. S. LAKHANI AND G. NATION
A. WILKIN, D. SANSOM, R. PARRY, J. WESTWICK AND
S. WARD
L. TURNER, S. G. WARD AND J. WESTWICK
K. M. BOTHAM, P. A. MAYES, M. AVELLA, A. CANTAFORA AND E. BRAVO
D. J. DUNICAN, R. GRIFFITHS, L. A. J. O’NEILL AND
D. C. WILLIAMS
J. C. FREEBURN, W. S. GILMORE AND J. J. STRAIN
277s
2785
279s
2805
2815
282s
2835
2848
2855
286s
The control of flux: 21 years on
A series of cases in which metabolic channelling can decrease the pool size at constant net flux in a simple dynamic channel
Top-down regulation analyses of palmitoyl-CoA oxidation and ketogenesis in isolated rat liver mitochondria
A mathematical model t o describe quinone pool kinetics and analyse control of respiration in plant mitochondria
lsoprenoid synthesis in peppermint (Mentha x giperita): development of a model system for measuring flux of intermediates through the mevalonic acid pathway in plants
In situ regulation of methylglyoxal metabolism
Regulation of oxidative and glycogenolytic ATP turnover in exercising rat skeletal muscle
Trans-sarcolemmal Pi fluxes in perfused rat heart: a quantitative analysis
Error and bias in control coefficients calculated from elasticities
P. MENDES, D. B. KELL AND H. V. WESTERHOFF 2875
R. A. MAKINS, L. F. DRYNAN, V. A. ZAMMIT AND
P. A. QUANT
2885
K. KRAB, C. W. M. VAN DEN BERGEN AND A. L. MWRE 289s
D. MCCASKILL AND R. CROTEAU 2905
C. A. CORDEIRO AND A. P. FREIRE
A. L. SANDERSON, G. J. KEMP, C. H. THOMPSON AND
G. K. RADDA
G. J. KEMP, K. E. POLGREEN, J. A. C. HOPKINS, K. CLARKE 2935 AND G. K. RADDA
S. THOMAS AND D. A. FELL
291s
292s
294s
n 0 3 rs 0 3 rs # I
C 3
0 3
3 r ) cn
P
I
Cytochrome c oxidase control by ApH and A Y gradients: effects of fatty acids
P. NICHOLLS. M. SHARPE AND C. TARBA 295s
Object-oriented metabolic programming 1. H. WOODS 296s
Design of experiments to measure elasticity coefficients 297s D. A. FELL
Stimulation of free radical reactions: a multi-compartment Monte Carlo approach
J. P. MONIZ-BARRETO AND D. A. FELL 2985
Lipid group
Lipid analysis in human intervertebral disc material G. OKTAY, A. GUNER, G. GUNER, M. KERMAN AND
U. PABUCCUOLU
A. ADJABI, N. BELATAR, H. AMANI AND S. AQUABED
299s
Study of phospholipids in mucilage (Gum) of sunflower, rapeseed and soja: analytical approach
Effect of phospholipid extracts from brain and egg on activated partial prothrombin time
Desaturation and esterification of palmitic and stearic acids in cultured hepatocytes
N-3 polyunsaturated fatty acids (PUFA) modulate the expression of functionally associated molecules on human monocytes
Molecular enzymology group
300s
A. ADJABI, S. AMOKRANE, N. BELATTAR AND
Y. BOUGUERN
j. S. BRUCE, S. RICHARDS, G. LEGRAND AND A. M. SALTER 302s
3015
D. A. HUGHES, A. C. PINDER, Z. PIPER AND E. K. LUND 303s
Cloning and expression of human intestinal sucrase- isomaltase
C. E. C. MCOLENAAR AND H. Y. NAIM
Analysis of the putative cleavage site in human lactase-phlorizin hydrolase
R. JACOB AND H. Y. NAIM
304s
305s
Peptidase content of the bile canalicular membrane
Substrate dependence of the mitochondria1 energy status in the isolated working rat heart
Localisation and characterisation of carbonic anhydrase isozymes (CA I, CA II, CA 111 and CA IV) in an umbilical vein endothelial cell line (EA-hy926)
Characterization of a human ductal pancreatic Capan-I clone (IMEH): carbonic anhydrases II and IV (CA II and CA IV) expression and targetting
Evaluation of alkaline phosphatase isoenzymes in sera of hemodialysis and periton dialysis patients by agarose gel electrophoresis
Small RNAs in the nucleus and cytoplasm
K. A. ZUZEL, J. G. GRAHAM, J. HRYSZKO, D. BILLINGTON AND A. J. TURNER
C. A. KEON, N. TUKHIYA, Y. KASHIWAYA, K. SATO, K. CLARKE, G. K. RADDA AND R. L. VEECH
I. MAHIEU, A. SAGGAR-MALIK, E. HOLLANDE AND
N. CARTER
3065
307s
308s
I. MAHAIEU, N. CARTER AND E. HOLLANDE 309s
G. OKTAY, M. FADILOLU. B. ONVURAL, T. CAMSARI AND 3 IOS A. CELIK
Effects of expression of the Epstein-Barr virus small RNA EBER- I in heterologous cells on protein synthesis and cell growth
Analysis of the double-stranded RNA binding properties of the La antigen
Interaction of the dsRNA-dependent protein kinase PKR with Epstein-Barr virus W RNAs
K. G. LAING, V. MATYS AND M. j. CLEMENS 31 I S
M. C. JAMES, G. j. M. PRUIJN. W. J. VAN VENRCOIJ AND
M. J. CLEMENS
E. ELIA, A. SCHOFIELD AND M. j. CLEMENS
3 12s
3135
Genomic organization of plant U I 4 snoRNA genes D. J. LEADER, J. F. SANDERS, A. TURNBULL-ROSS, R. WAUGH AND J. W. S. BROWN
T. OHLMANN, M. RAU, S. MORLEY AND V. M. PAIN
314s
Effect of cleavage of the p220 subunit of eukaryotic translation initiation factor elF-4F on protein synthesis in vitro
Features of the translational regulation of the mammalian growth-related protein P23
315s
A. V. BOROVJAGIN, P. RUSSELL, M. J. CLEMENS, M. A. GREAGG AND U.-A. BOMMER
316s
Regulation of carbohydrate metabolism in muscle and liver
Profiles of sorbitol dehydrogenase and Na+/K+-ATPase activity in a rat brain capillary cell line in various glucose concentrations may suggest an endothelium- protective mechanism
Restoration o f hepatic metabolism by cold reperfusion
Glycogen metabolism in G8 mouse muscle cells
Characterization of membrane bound carbonic anhydrase IV (CA IV) located on the external surface o f lung pulmonary endothelial cells
Hepatic glucokinase activity in animals fed glucose at birth
Endotoxin causes reciprocal changes in hepatic nitric oxide synthesis and gluconeogenesis
Measurement of glycogenin utilization for glycogen synthesis in type II diabetic cells by use of a specific immunoassay for apo-glycogenin
Inhibition of nitric oxide synthase by L-arginine metabolites
C. N. B. ECHETA AND K. R. F. E L L I O ~ 317s
S. J. MITCHELL, T. A. CHURCHILL AND B. J. FULLER
Y. S. ANDERSON, C. A. WOOD AND G. K. RADDA
I. MAHIEU, A. BENJAMIN, R. STEPHENS, D. WALTERS AND
N. CARTER
318s
319s
320s
H. LYALL, D. TOSH AND A. BURCHELL 321s
R. A. HORTON, R. G. KNOWLES AND M. A. TITHERA~CE 322s
J. M. BAILEY, E. P. LILLEHOJ, A. N. SIDAWY, B. JONES AND 323s J . L. COHEN
I. DAS AND N. S. KHAN 3248
Nucleic acids and molecular biology group
Inhibition of Pax 5 activity by expression of i t s DNA binding domain
Duodenal expression of NF-E2 in mouse models of altered iron metabolism
The effect of various stretch and electrical stimulation regimes on proto-oncogene induction in skeletal muscle
Growth hormone induction and somatostatin suppression of hepatic proto-oncogenes and IGF- I in the rat
lmmunolocalization of proto-oncogene expression in mechanically stimulated skeletal muscle
Upregulation of calreticulin expression in HeLa cells by calcium-stress
The cytotoxicity of anthramycin to mutants o f Schizosoccharornyces pornbe deficient in D N A damage responses
G. Z. HASTINGS AND B. ADAMS 325s
K. B. RAJA, B. GERARD, A. MCKIE, C. BEAUMONT, R. J. SIMPSON, B. GRANDCHAMP AND T. J. PETERS
N. J. DAWES, D. M. LEE, V. M. Cox, H. NGA AND
D. F. GOLDSPINK
326s
327s
J. PENMAN, S. LIU, P. BELCHETZ AND D. F. GOLDSPINK 3285
D. M. LEE, N. J. DAWES, V. M. Cox, J. E. HESKETH AND 329s D. F. GOLDSPINK
D. H. LLEWELLYN. F. N. SHEIKH, J. M. KENDALL AND
A. K. CAMPBELL
F. HAW, D. E. THURSTON, A. M. CARR AND R. W. JONES 331s
330s
I; P 3
3 ~
v)
I 8 3 111
5 C 111
The role of zinc in the structure and function of the transcription factor BSAP (PAX-5 gene product)
J. M. GCODING AND B. ADAMS 3325
Protein and DeDtide science grow
Haem and non-haem iron in pig tissues and vitro
Production of soluble surface glycoprotein GP70, of
G. 0. LATUNDE-DADA
J. M. ALLEN, M. ALI AND M. 0. MCCLURE
333s availability studies
the Mason-Pfizer monkey virus in COS cells is dependent on the presence of regions of the transmembrane domain
334s
Regulation in metabolism group
methionine synthase by protein kinase A
In vivo hepatic energy perturbations during alanine infusion using )IP-NMR spectroscopy
In vitro phosphorylation of vitamin B,, dependent S. H. KENYON, T. AST AND W. A. GIBBONS 335s
K. K. CHANGANI, M. L. BARNARD, J. D. BELL, S. C. R. WILLIAMS, S. R. BLOOM AND R. A. ILES
336s
Insulin insensitivity in the ischaemic heart J. C. A. HOPKINS, K. CLARKE AND G. K. RADDA
K. LAZOUW, D. POUNTNEY AND R. J. SIMPSON
337s
338s Inhibition of duodenal mucosal ferricyanide reductase
~
Miscellaneous
Regulation of lysophosphatidic acid-stimulated tyrosine phosphorylation of pp42 mitogen-activated protein kinase C and protein kinase A in EAhy926 cells
A. MCLEES, A. GRAHAM, K. MALARKEY, G. W. GOULD AND R. PLEVIN
339s
Lignin peroxidase catalysis: reaction with veratryl alcohol and a polymeric dye, Poly R
The permissive effect of serum on the inhibition of mitogen-activated protein kinase by forskolin in vascular smooth muscle cells
P. J. HARVEY, L. P. CANDEIAS, P. J. KING, J. M. PALMER AND R. WEVER
D. M. AIDULIS, K. MALARKEY, A. MCLEES, G. W. GOULD 34 I S AND R. PLEVIN
340s
Spectra and reactivity of the radical cations of lignin peroxidase co-factors and model compounds
L. P. CANDEIAS AND P. HARVEY 342s
Irish Area Section Meeting on Environmental Biochemistry, University College Cork
Ca2+ transport in erythrocytes from a hibernating and non-hibernating species
Regulated nuclear entry of a yeast transcription factor
The cloning and expression of the a subunit of equine glycoprotein hormones
Rheological and syneretic properties of acid gels fortified with whey proteins
Adenomatous polyposis coli gene mutations in Irish pedigrees with familial adenomatous polyposis
I -Methyl-4-phenylpyridinium and catechol-0- methyltransferase
A comparison of the regulation of de novo cholesterol synthesis by LDL and LP(a)
E. R. HORWITZ AND J. C. ELLORY 345s
D. NEILL, M. MCNAMARA AND G. BUTLER
M. OBRIEN AND D. R. HEACON
346s
347s
G. CURTIN, R. MEHRA, T. GUINEE, B. OKENNEDY, B. CONNOLLY AND D. SHEEHAN
M. J. OSULLNAN, T. MULCAHY, C. B. 0. SUILLEABHAIN, W. 0. KIRWAN, C. T. DOYLE AND T. V. MCCARTHY
J. M. BYRNE AND K. TIPTON
3485
349s
350s
S. M. GILLIGAN AND P. B. COLLINS 351s
Mutation screening of dihydropyridine receptor y subunit cDNA from malignant hyperthermia susceptible patients
The complementary actions of proline specific enzymes of guinea-pig brain
Seasonal variations in the levels of antioxidant enzymes in Mytilus edulis
The detection of bovine herpesvirus I in routine diagnostic submissions using PCR
Investigation of glucocorticoid modulation of apolipoprotein mRNA transcription
Use of proton NMR spectroscopy in the toxicological evaluation of new anti-mycobacterial agents
Regulation of Ca2+ release from the ryanodine receptor of sarcoplasmic reticulum
Gene expression in bovine mammary tissue at different stages of the oestrus cycle
Differential reactivity of native and recombinant xGST in various assay systems
Perturbations in the cytosolic free calcium ion concentration in isolated cells exposed to certain organic atmospheric pollutants
Use of HPLC for the determination of serum 7a-hydroxycholesterol in cholestyramine-treated rats
Comparative immunoblot analysis of the guanine nucleotide binding protein Gqa in control and Alzheimer's disease brains
Evidence from affinity precipitation that glutamate analogues are bound in a folded conformation to glutamate dehydrogenase
Resolution of lactate dehydrogenase isoforms by affinity precipitation
Purification of a-acetolactate synthase from Leuconostoc lactis NCW I
Response of root surface phosphatase activity of Molinia caerulea (L.) Moench, the purple moor grass, t o edaphic environments
Effect of probenecid and pyridoxal-5-phosphate on the aggregation of rat blood platelets
Thermal denaturation as a predictor of stability on long-term storage of a protein
Soluble protein changes in pollution-adapted Gammarus duebeni
Identification of novel ligands for the peripheral-type benzodiazepine receptor
P. J. LYNCH, F. J. COUCH, R. G. GREGG, P. A. POWERS, K. HCGAN AND T. V. MCCARTHY
352s
L. GILMARTIN 353s
354s A. POWER AND D. SHEEHAN
S. MOORE, M. GUNN AND D. WALLS
M. M. MACMAHON AND W. M. C. LOVE
355s
356s
R. OCONNOR, R. O'KENNEDY AND P. JAMES
G. H. OSULLIVAN AND J. J. A. HEFFRON
357s
3585
N. A. SEELY, J. SREENAN, D. MORRIS AND D. R. HEADON 3595
F. MANNING, A. CONWAY AND S. DOYLE
J. MC~NTOSH AND J. J. A. HEFFRON
L. D~WLING AND R. DEVERY
C. SHANAHAN, M. DEASY, R. RAVID AND C. ONEILL
M. ODONNELL, M. MAHER AND T. GRIFFIN
J. A. IRWIN AND K. F. TIPTON
N. M. CARROLL, D. SHEEHAN AND T. M. CWAN
K. A. SALIM, D. GORDON, S. SHAW AND C. A. SMITH
N. EL-NAGEH AND M. G. HARRINGTON
C. TWOMEY, S. DOONAN AND A. GIARTOSIO
L. JERVIS AND M. B. JONES
D. M. ZISTERER AND D. C. WILLIAMS
360s
361s
3625
3638
3645
3655
366s
367s
3685
369s
370s
371s
I)
3
3 rt v)
0
0 I
I 8 3 3
F S =I
=I u)
Haplotype analysis of the RYRl gene in malignant hyperthermia and central core disease
Aggregation characteristics of platelets in stored concentrates of human blood
Purification of glutathione S-transferases from Yarrowia lipolytica
Oxidative stress and human ageing
Relationship between early diet and subsequent cognitive performance during adolescence
Studies on the GTP binding ability of the human Rabrlp, expressed in E. coli
The significance of adenine phosphoribosyl- transferase for DNA repair processes in Friend cells
Cloning of electron-transferring flavoprotein from Megasphaera elsdenii
Construction of a recombinant HRab I A Baculovirus
The effects of mutating aspartate-95 and aspartate- I27 on the thermodynamic properties of Desulfovibrio vulgaris flavodoxin
Structural investigation of a glutathione binding site using computational analysis
Can PCR be used t o normalise a cDNA library?
Cloning of the gene for flavodoxin from the anaerobic bacterium Megasphaera elsdenii
Validation of a HPLC method for measurement of collagen crosslinks in urine - potential biomarkers for osteoporosis
Purification of collagen crosslinks; potential biomarken for bone disorders
Potassium ferrate as a DNA chemical sequencing reagent and probe of secondary structure
Cysteine plays a role in catalysis in glutathione S-transferase I - I Purification and properties of salmon liver biliverdin reductase
Co-purification from human blood plasma of activated factor XI1 with albumin with dye-ligand and metal- chelate chromatography
Expression of gelatinolytic activity by oesophageal and colon carcinoma cell lines
The relationship between volume-sensitive taurine efflux and the anion-exchanger in lactating mammary tissue
K. A. QUANE, K. E. KEATING, J. M. S. HEALY, J. J. A. HEFFRON, M. LEHANE, R. KRIVOSIC-HORBER, L. HEYTENS AND T. V. MCCARTHY
M.-L. NOLAN AND M. G. HARRINGTON
V. FOLEY AND D. SHEEHAN
C. M. KING AND Y. A. BARNETT
L. C. GREENE, A. LUCAS, M. B. E. LIVINGSTONE P. S. E. G. HARLAND AND B. A. BAKER
F. OBRIEN AND M. W. MCCAFFREY
A. A. NELSON, K. JOYCE, P. G. MCKENNA AND
Y. A. BARNETT
H. M. ONEILL, G. BUTLER AND S. G. MAYHEW
F. J. DRUMMOND AND M. W. MCCAFFREY
D. P. OCONNELL, G. VOORWW AND S. G. MAYHEW
T. R. BARRY, P. WATERS, S. NAN AND
D. SHEEHAN
C. POPE, P. V. NESTOR, C. MORRISON AND F. GANNON
S. M. GECGHEGAN, G. BUTLER AND S. G. MAYHEW
U. M. CASSERLY, B. J. MCGUINNESS, M. J. POWER AND
P. F. FOTTRELL
B. J. MCGUINNESS, U. M. CASSERLY, M. J. POWER AND
P. F. FOTRELL
C. STEVENSON AND R. J. H. DAVIES
R. M. MCCARTNEY AND D. SHEEHAN
G. ELLIOTT AND T. J. MANTLE
B. J. MION AND B. F. MASTERSON
P. DELLA PORTA, N. M. RYAN AND J. K. COLLINS
D. 8. SHENNAN, S. A. MCNEILLIE AND M. J. CLIFF
372s
373s
374s
375s
3763
377s
378s
379s
380s
381s
382s
383s
384s
3856
386s
3875
3885
3895
390s
3915
392s
The dependance of the detection limit of reagent- T. O'CONNOR, M. M. KANE AND 1. P. GOSLING 393s limited immunoassay on antibody affinity
The relative protein disulphide isomerase (PDI) C. C. CHEW, T. MAGALLON, N. MARTINAT, F. LECOMPTE, T. COMBARNOUS AND J. P. GOSLING
394s activities of gonadotrophins, thioredoxin and PDI
n 0 3
3 r ) M
ri 1