Thomas HoyThomas Hoy

Department of Biomedical Engineering Department of Biomedical Engineering BME 273 Senior Design BME 273 Senior Design

January 30, 2004January 30, 2004

Project DefinitionProject Definition What is a Ostium What is a Ostium

Secundum Atrial Septal Secundum Atrial Septal Defect?Defect?• congenital heart diseasecongenital heart disease• causes left to right causes left to right

shunting across interatrial shunting across interatrial septumseptum

Why should we care?Why should we care?• Isolated secundum atrial Isolated secundum atrial

septal defects of septal defects of significance occur in significance occur in approximately 70,000-approximately 70,000-100,000 individuals today.100,000 individuals today.

• Isolated ASDs can cause Isolated ASDs can cause congestive heart failure or congestive heart failure or Eisenmengers syndrome Eisenmengers syndrome

GoalsGoals To develop a less To develop a less

costly occlusion costly occlusion device for an ASD.device for an ASD.

To develop an To develop an occlusion device that occlusion device that is easily sized to the is easily sized to the ASD.ASD.

To ensure easy use of To ensure easy use of this device in this device in medicine.medicine.

Further GoalsFurther Goals

To design a device that should:To design a device that should:• Provide more accurate application Provide more accurate application • Less strain on the applied interatrial wallLess strain on the applied interatrial wall• Stimulate endotheliazation of the deviceStimulate endotheliazation of the device• Be lower in cost and more simplistic in Be lower in cost and more simplistic in

designdesign• Improve the quality of life of the patientImprove the quality of life of the patient

Common Occlusion DevicesCommon Occlusion Devices

Amplatzer – most Amplatzer – most widely usedwidely used

HELEX DeviceHELEX Device Das Angel WingsDas Angel Wings ASDOSASDOS STARFlex OccluderSTARFlex Occluder Sideris "Buttoned Sideris "Buttoned

Device" Device"

Amplatzer Occlusion DeviceAmplatzer Occlusion Device

ResearchResearch• Study of engineering Study of engineering

aspects of the aspects of the Amplatzer designAmplatzer design

• Study of how devices fit Study of how devices fit into catheters and how into catheters and how they work.they work.

Brainstorming possible Brainstorming possible solutions to these solutions to these problemproblem

Amplatzer DeploymentAmplatzer Deployment

Patient is sedatedPatient is sedated

Dynamic X-ray device Dynamic X-ray device used with dye to place used with dye to place the devicethe device

Conformation through Conformation through trans-esophageal trans-esophageal echocardiogramechocardiogram

Amplatzer DetachmentAmplatzer Detachment Locking Locking

mechanism mechanism screws into placescrews into place

Device is Device is unscrewed from unscrewed from cathetercatheter

Amplatzer is able Amplatzer is able to be recaptured to be recaptured if a problem were if a problem were to arise.to arise.

Before and AfterBefore and After

Future WorkFuture Work

Scheduled another meeting with Scheduled another meeting with advisor to discuss progressadvisor to discuss progress

Continued brainstorming and Continued brainstorming and documentation of possible designs documentation of possible designs and implementation devicesand implementation devices

Study engineering possibilities of Study engineering possibilities of designs and modeling for catheter designs and modeling for catheter deploymentdeployment

ModelModel

Works CitedWorks Cited Moodie DS, Sterba, R. Long-term outcomes excellent for Moodie DS, Sterba, R. Long-term outcomes excellent for

atrial septal defect repair in adults. Cleveland Journal of atrial septal defect repair in adults. Cleveland Journal of Medicine 2000; 67(8):591-597.Medicine 2000; 67(8):591-597.

Hughes ML, Maskell G, Goh TH, Wilkinson JL. Prospective Hughes ML, Maskell G, Goh TH, Wilkinson JL. Prospective comparison of costs and short term health outcomes of comparison of costs and short term health outcomes of surgical versus device closure of atrial septal defect in surgical versus device closure of atrial septal defect in children. Heart 2002; 88:67-70.children. Heart 2002; 88:67-70.

Thomson JDR, Aburawi EH, Watterson KG, Van Doorn C, Thomson JDR, Aburawi EH, Watterson KG, Van Doorn C, Gibbs JL. Surgical and transcatheter (Amplatzer) closure of Gibbs JL. Surgical and transcatheter (Amplatzer) closure of atrial septal defects: A prospective comparison of results atrial septal defects: A prospective comparison of results and cost. Heart 2002; 87:466-469.and cost. Heart 2002; 87:466-469.

AGA Medical Corporation, AGA Medical Corporation, http://www.amplatzer.com/products/aso_imp_demo.htmlhttp://www.amplatzer.com/products/aso_imp_demo.html