Thermo Scientiﬁc TSQ Quantum XLS Ultra Triple Quadrupole GC … · The Thermo Scientific TSQ...

Introducing Ultra Selective GC-MS/MS

Thermo Scientific TSQ Quantum XLS Ultra

Triple Quadrupole GC-MS

Persistent Organic Pollutants

Food Safety

Drug Screening

Forensic Evidence

Sports Doping

Part of Thermo Fisher Scientific

c h r o m a t o g r a p h y

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The Gold Standard in GC-MS/MSHigher Mass Resolution with breakthrough Ultra Selective Reaction Monitoring (U-SRM).Best in class selectivity and precision for an extensive range of GC/MS applications.Fast GC runs for multi-component analysis of more samples simultaneously.

Low fg Sensitivity

Greatly Increased Mass Resolution

Unsurpassed Analyte Selectivity

Highest Productivity for Real Life Samples

The Thermo Scientific TSQ Quantum XLS Ultra triple quadrupole mass spectrometer is the highest performing GC-MS/MS instrument available. It features best in class target compound selectivity, analytical performance,and lab productivity – its the new “Gold Standard” from the technology leaderin GC-MS/MS.

HyperQuad™ technology is included which delivers highly increased massresolving quadrupoles for ultra selective SRM, with best in class sensitivity,and allows unsurpassed analytical performance for the most difficult of matrix challenges.

This is the most selective GC tandem quadrupole instrument available,yielding ultimate analytical performance particularly with regards to discrimination against chemical matrix background and detection of targets.Consequently, the TSQ Quantum XLS Ultra™ GC-MS/MS is expressly applicablefor labs seeking high performance and productivity advantages, especially inenvironmental, food safety, forensics, drugs and doping applications.

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The Highest Performing GC-MS/MS Instrument Available


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Unique Value for Your Most Challenging AnalysesThe increased resolution offered by the new TSQ Quantum XLS Ultra GC-MS/MSenables more precise and reliable analyses to meet rigorous international standards.

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Unique Target Compound Selectivity for POPs, Dioxin/dl-PCBs and Bioactive Compounds

• HyperQuad technology for very highly resolved Q1 precursor selection (< 0.2 Da U-SRM)

• Unsurpassed analyte selectivity in very complex matrix extracts• Superior results from less cleaned real life sample extracts• Reliable, first time peak integration, quantitation• Ion ratio confirmation compliant to official regulations

Superior Sensitivity, Superior Precision

• High precision at lowest concentration levels • Lowest LOQs e.g. at low fg levels for TCDD• LOD < 1 ppb in typical difficult biological matrices as urine,

blood, plan tissue

High Productivity

• Save precious sample prep time • Screen more compounds in one run• Especially suited for multi component trace analysis• Designed for fast-GC applications (10 –15 m column lengths)• t-SRM acquisition for more than 1000 compounds in one fast run

Exceptional Robustness

• Maximum uptime for unattended operation with proven IRIS source

• Unique matrix pre-filter• Robustness for a large number of matrix samples • Ion volumes for quick exchange by vacuum interlock

Ease-of-Use – Workflow Software

• Simplified method installation and maintenance from Master Methods

• Workflow software with custom reporting tools


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DuraBrite IRIS technology offers greatersensitivity, extended maintenance cyclesand strong routine matrix robustness allowing more samples to be analyzed and increasing laboratory productivity.

DuraBrite™ IRIS Technology InsideDuraBrite IRIS technology delivers greater sensitivity and extended maintenance cycles for more samples and more productivity.

Experience the benefit of Exchangeable Ion Volumes:replace the ion volume without venting the MS system.Designed for quick source maintenance, or for changingfrom EI to NCI or PCI operation and back for increasedsystem uptime.

The new DuraBrite IRIS source technology delivers double benefits: highly inert materials prevent sensitive compounds such as drugs and pesticides from degrada-tion and matrix components cut by the pre-filter do notenter the quadrupole analyzer.

High-throughput, workflow oriented software boosts lab efficiency.


Single reaction monitoring (SRM) has become an established technique for analyzing target compounds in the most challenging of matrices.

With the Thermo Scientific TSQ Quantum XLS GC-MS/MS, weintroduced highly selective SRM (H-SRM). This capability allowedlaboratories to target compounds with cleaner backgrounds thanever before. The desire to produce fast results, however, oftenmeans sample purification steps are reduced and as a result, evenhigher performance is required from their GC-MS/MS systems.

Building on the success of the Quantum XLS™ system, anotherstep up in SRM selectivity with Ultra Selective SRM (U-SRM) isintroduced with the TSQ Quantum XLS Ultra GC-MS/MS. HyperQuadtechnology allows increased resolution of up to 0.1 amu. This translates into the most selective SRM available.

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Ultra Selective GC-MS/MS......when Standard SRM Isn’t Enough

Optimize Clean-up Procedures

Leave your Background Interferences behind

at the First Stage of MS

Reduce Chemical Noise

Extend Limits of Detection in the Most Difficult Matrices

Improve Peak Integration Efficiency with Cleaner Mass Chromatograms

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During U-SRM, Q1 (first quadrupole) is set to only transmit the precursor mass of the target compound within a < 0.2 m/z window. This means there is less opportunity for interfering masses to be transmitted to enter the collision cell, ultimatelyreducing chemical noise.

This reduction in noise allows increased detection capability insome of the most difficult matrices. It also extends the possibilityfor less vigorous sample clean-up to be carried out.

Another advantage is cleaner mass chromatograms than everobtained before, allowing easy peak identification and integration.This means data can be evaluated quickly and easily, providingfaster answers for high through-put laboratories.

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Compelling Solutions...Your lab’s next competitive advantage.

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The TSQ Quantum XLS Ultra triple quadrupole mass spectrometeraddresses the requirements of the most demanding analytical tasksacross applications. Food safety, environmental, clinical, forensic,toxicology, pharmaceutical and metabolomic sanalyses can all benefit from the highest performing instrument available.

Unsurpassed Target Compound SelectivityClinical, forensic/doping, toxicological, metabolomic, and pharmacokinetic quantification /screening all require exceedingly selective MS analyzers. Reliable results that withstand any legal interrogation are key in drug related applications. The TSQ Quantum XLS Ultra GC-MS/MS comes with selectivity that isunmatched by any other GC triple quadrupole analyser.

Chromatographic Integrity in Difficult MatricesBioanalysis takes advantage of GC/MS/MS analysis for small molecule quantitation. Metabolomics applications especially requiretarget compound GC/MS quantitation for small compounds in difficultmatrices which benefit from the extraordinary selectivity androbustness of a TSQ Quantum XLS Ultra GC-MS/MS.

Designed for Tomorrow's ChallengesFrequent contamination crises in both food and environmental sectors result in extensive monitoring programs with lower detectionlimits and high sample matrix diversity. This is a big challenge forlaboratories which leads to the need for powerful analyticalmethodologies to be able to succeed. From POPs to pesticides, withfemtogram level sensitivity and U-SRM capability, the TSQ QuantumXLS Ultra GC-MS/MS delivers a complete system that is capable ofmeeting the regulatory challenges of both today and tomorrow.

TSQ Quantum XLS Ultra GC-MS/MS: 2378-TCDD in anon-compliant milk sample (top: 2 transitions for nativeTCDD and 2 for 13 C labeled IS TCDD below).

A fast decision on compliance or non-complianceregarding maximum TEQ levels can be made.


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TSQ Quantum XLS Ultra GC-MS/MS analysis of lindane isomers ingreen tea. Signal/noise increases significantly due to heightenedresolution and reduced chemical background in the chromatogram.

Endrin 1 pg in contaminated land sample ran both in SRM (Q1 0.7 amu) and U-SR< (Q1 0.1 amu).

Animal fat sample with reduced sample clean-up PCDD/F-TEQ value is 0.95 pg/g fat. 125 fg of 2,3,7,8-TCDD injected.


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Maximize Productivity with Workflow-Oriented Software Options

Powerful software packages follow laboratory workflows for maximum productivity.

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Simplified workflows for efficient navigation

Dynamically linked datareview and reporting

Lab Forms Software PackagesThe TSQ Quantum XLS Ultra system offersreliable, robust performance, ideally suitedfor GC/MS applications from research toroutine. Thermo Scientific Lab Forms applications – QuanLab™ Forms, EnviroLab™

Forms and ToxLab™ Forms – complement routine GC/MS applications and streamlineyour workflows.

Lab Forms Core CapabilitiesThe Lab Forms packages offer common user tools that simplify workflows and make getting from sample to result easierand more efficient.

Easy Navigation A dashboard guides users to their activities tomove quickly to the desired mode. Configureand customize the application, develop andcreate methods, or focus on daily productionto program batches, review data, and generate reports.

User Role CapabilitiesOptional user roles allow you to controlaccess to program settings and functionsbased on the user’s job types. This allowssimplified routine workflows and protectsmethods and data from inadvertent changes.

Optimized Data ReviewThe Lab Forms Data Review environment isdesigned to simplify reviewing complexdata sets by incorporating easy-to-interpretflags. These flags can highlight data thatfalls outside of your lab’s criteria, allowingyou to easily spot and correct any issues,simply and easily.

Active ReportingWhere the Lab Forms software packages trulyredefine workflows is with a revolutionaryapproach to data review and reporting.Through powerful Smart Reporting, datareview and data reporting are dynamicallylinked in Active View, allowing for real-timechanges to the reports based on changes tothe data. Any changes to data are immediatelyreflected in the report – no reprocessing, noreanalyzing the data. Manual integrations areflagged for auditing purposes, so a record iskept of the changes made to the batch.

Custom ReportsLab Forms software offers the ability to use custom reporting by creating specialMicrosoft® Excel® reports. These customreports can be automated at a batch orsample level, using the same processes as the integrated standard reports.

QuanLab FormsQuanLab Forms comes with your TSQQuantum XLS Ultra system, providing youwith a simple tool for routine GC/MS dataacquisition, analysis and reporting. A wideselection of standard, pre-configured reportsallows you to easily report data in a style thatsuits your lab’s needs, plus customizablereports allow you to tailor reports for yourspecific applications. Generate reports inreal time during sample acquisition, orreview and report data through the intuitiveData Review screen.


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Thermo Scientific TargetQuanThe dedicated quantitation package isspecifically designed for the isotope dilutiontechnique, covering protocols like EPA 1613,JIS K 0311/0312, or EN 1948.

Dedicated Quantitation PackageTargetQuan software, is available as part ofthe Thermo Scientific Xcalibur data system.It has been tailored to the EPA, EN, and JISprotocols for analysis of persistent organicpollutants, such as halogenated dioxins andfurans, polychlorinated biphenyls, brominatedflame retardants, and many more. The software package consists of three individualprograms, TargetQuan, Response, andReporter. TargetQuan software is the mainquantitation application, which includes the user interface for method setup, peakintegration, and result viewing. Responsedeals with calibration curves, while Reporterhelps to created printed or electronic chromatogram documents.

Features

• Quantitation based on relative responsefactors (RRF)

• User definable dependency of standards• One quantitation mass and up to two

ratio masses for confirmation based onisotopic abundance

• Freely configurable spreadsheet for dataviewing and method setup

• Automated or manual peak integration • Retention time correction• Toxicity equivalents (TEQ) according to

WHO definition including lower, medium,and upper boundary calculation

• User definable summation of calculatedamounts or TEQs for reporting of sumTEQ values

• Allows quantitation based on averageresponse of selected compounds (for EPA 1613)

Ready To GoThe software comes with templates forquantitation of polychlorinated dioxins, furans(like EPA 1613 and more), and other POPs.

Automation Built-in scripting allows for full automationfrom creating a calibration curve to measuringsamples unattended. The simple scriptingfunctionality enables you to tailor the softwareto follow the workflow of your laboratory.

Reporting Spreadsheets can be printed, saved, exported,or emailed directly from the TargetQuanapplication. Columns, headings, and displaysettings can be arranged as desired andsaved as layout files for easy access. TheReporter application comes with an intuitiveeditor for creating reporting templates using‘drag-and drop’ objects.

Using the templates, chromatogramreports can be printed or stored as documentfiles automatically from a sequence.

LIMS ExportAny selected set of parameters and compound can be exported to a LIMS system using CSV, ASCII, or XLS file export. File export can be initiated automaticallythrough a sequence, or manually.

Xcalibur Data SystemThe Xcalibur™ data system provides confidentcontrol from method development to reportingusing the TSQ Quantum XLS system. Xcalibursoftware is also used to provide tools forgenerating and maintaining your own spectrallibraries. It is compatible with commerciallibraries such as NIST, Wiley, Maurer-Pfleger-Weber and others. Xcalibur software providescomplete control of the TRACE GC Ultra and FOCUS GC, the mass spectrometer andoptional liquid or headspace autosamplers.

Easy Interpretation ofMass Spectral DataThermo Scientific Mass Frontier softwareprovides a suite of options that allows theMS operator to interpret mass spectraldata. This optional software package assiststhe operator in structural identification,isotope pattern determination, and spectralclassifications.


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©2011 Thermo Fisher Scientific Inc. All rights reserved.Mass Frontier is a trademark of HighChem Ltd. Microsoftand Excel are registered trademarks of MicrosoftCorporation. All other trademarks are the property ofThermo Fisher Scientific Inc. and its subsidiaries.

Specifications, terms and pricing are subject to change.Not all products are available in all countries. Pleaseconsult your local sales representative for details.

Tap our expertise throughout the life of your instrument. Thermo Scientific Services

extends its support throughout our worldwide network of highly trained and certified

engineers who are experts in laboratory technologies and applications. Put our team

of experts to work for you in a range of disciplines – from system installation, training

and technical support, to complete asset management and regulatory compliance

consulting. Improve your productivity and lower the cost of instrument ownership

through our product support services. Maximize uptime while eliminating the

uncontrollable cost of unplanned maintenance and repairs. When it’s time to

enhance your system, we also offer certified parts and a range of accessories and

consumables suited to your application.

To learn more about our products and comprehensive service offerings,

visit us at www.thermoscientific.com.

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Thermo Scientiﬁc TSQ Quantum XLS Ultra Triple Quadrupole GC … · The Thermo Scientific TSQ...

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