Unstoppable productivity

Thermo Scientific ISQSingle Quadrupole GC-MS

Part of Thermo Fisher Scientific

c h r o m a t o g r a p h y

The Ideal Solution for Truly UnstoppableGC-MS Productivity

Let’s face it. The reality of using GC-MS systems for analysis of samples – clean, dirty, complex, orroutine – means that your system will get dirty. Stopping to clean the instrument means lost time, lostmoney, and lost resources. Even scheduled maintenance means rearranging priorities and shifting ofwork to take care of the cleaning. It’s a day of work, gone.

Not anymore.Re-think the way your lab operates with the Thermo Scientific ISQ single quadrupole GC-MS system. The ISQ™ GC-MS incorporates a newsource design that lets your system stay cleaner, longer. With heat throughout the ion optics, the ISQ can analyze more dirty samples perday, with maximum uptime. Better yet, when the instrument finally requires cleaning, the new source design can be fully removed –including all of the lenses and the repeller – through the front vacuum interlock, without venting the system. This lets you clean your source,swap it, or change ionization type, and be ready to run samples within minutes, not hours or days. Why break your workflow when you canhave unstoppable productivity?

Innovation with a Purpose– Your Lab’s SuccessToday’s technology is changing fast, andyour lab is changing too. The ISQ representsa new design, not an incrementalimprovement, and it includes the latest intoday’s technology and knowhow. Withthe ISQ, there is no need to buy differentGC-MS systems from different vendors toperform different tasks. The ISQ deliversexcellent performance for routine GC-MSanalyses, while incorporating innovativeadvances that allow you to easily expandyour lab’s test ranges or incorporate newsample analysis techniques. This innovationlies in the new ExtractaBrite™ source, theheart of the ISQ mass spectrometer.

The Heart of the ISQThe ISQ is designed to stay cleaner, longer,to maximize your instrument’s uptime andimprove your lab’s productivity. The need tobreak vacuum, cool off your system, andspend hours cleaning, reassembling, andrestoring the system is gone. The heatedion volume, lens stack, and ion optics pathin the ISQ ensure that the system stayscleaner longer, but when the system nolonger meets your analytical needs,restoring performance is quick and easy.The ExtractaBrite source incorporates acartridge that contains the repeller, sourcelenses, and RF lens, all of which can beremoved from the instrument while stillunder vacuum. What once took hours, oreven an entire day, is now accomplished inminutes.

Thermo Scientific ISQ

Single Quadrupole G

C-MS

ISQ Feature Benefits •Extend instrument uptime with unique Full Source Removal™for continuous day-in, day-out operation

• Improve sample throughput using the industry's fastest scanrate across a usable mass range for use with today’shigh-performance gas chromatographs

•Extended mass range for analytical versatility•Sequential Full Scan/SIM for confirmation and screening inthe same analysis

Advanced Technology,Routine ApplicationsThe ISQ single quadrupole massspectrometer consists of the ExtractaBritesource, S-shaped ion guide, solid metalquadrupole rods, and the Thermo ScientificDynaMax XR detection system. Thispowerful combination provides a systemthat gives you unmatched analyticalperformance with the benefit of extendingthe time between instrument maintenancecycles.

Heat – Right Where it BelongsThe entire ion source and lens stack isheated, not just the ion volume. More heatequals more robustness. Plus, the S-Shapedion guide protects the analyzer rods fromcontamination. There is no need to worryabout cleaning, heating, or replacing therod set – it is not subject to contamination.

Time to Clean? No Time Lost!The ExtractaBrite source features a high-temperature source and independentlyheated lenses. The cartridge sourceincludes the repeller, ion volume, lensesand RF lens. This entire cartridge can beremoved from the front of the ISQ withoutbreaking the system vacuum. Fully restoreinstrument performance in minutes.

Performance without CompromiseExcellent sensitivity in all modes of analysis– Page 4

ExtractaBrite SourceInert, high-temperature source for excellenttransmission and robustness– Page 6

Extended Mass Range1.2 – 1100 u with unit mass resolutionthroughout the range– Page 7

DynaMax™ XR Detection SystemBroadest electronic dynamic range inthe industry– Page 7

Software that Works for YouSoftware solutions to streamline workflows– Page 8

GC and Autosampler OptionsFlexible, efficient and powerful sampleintroduction and separation– Page 10

Analytical Flexibility and VersatilityOptions for applications from research toroutine– Page 11

GC-MS Columns and SuppliesHigh-quality Thermo Scientific and certifiedsupplies for optimal analytical results– Page 13

QUICK LINKS

Ease of Use Built Right InThe ISQ GC-MS system is designed toeasily fit into your laboratory’s workflows.Easy to learn, easy to use, and easy tomaintain – the ISQ was developed to meetthe needs of the modern analyticallaboratory. Whether you’re upgrading fromGC detectors to GC-MS, adding a newsystem to your lab, or just getting startedwith GC-MS, the ISQ offers the right mix ofpower and simplicity.

Rugged enough for demanding 24/7operations, the ISQ also provides for futuregrowth and expansion by being easilyupgradeable. This flexibility means that yourinvestment is protected, and your lab’sability to change to meet changingenvironments is assured.

Extended Mass Range– More Compounds to CoverThe ISQ offers an extended mass range,from 1.2 to 1100 u. This wide mass rangemeans that your lab can perform analysesacross the broadest range of compounds.Because the ISQ is compatible with directsample introduction, you are not limitedto the mass range of compounds that areGC-able, allowing you to further exploitthis mass range.

Enhanced Transferline DesignThe ISQ features an optimized GC-MSinterface. This transferline evenlydistributes heat across the length of theanalytical column, ensuring that there areno hot or cold spots, which in turn deliversGaussian peak shapes, even for high-boilingcompounds.

The Right GC-MS System for Today’s Challenges,Tomorrow’s Opportunities

Thermo Scientific ISQ

Single Quadrupole G

C-MS

Decabromobiphenyl and decabromobiphenyl ether,demonstrating excellent peak shape

Decabromobiphenyl

Decabromobiphenylether

Meet Demanding PerformanceRequirements, Day In and Day OutWhat do you give up when you move tounstoppable productivity? With the ISQ youdon’t have to compromise performance forproductivity. Today’s GC-MS assays demandultimate sensitivity for meeting strictregulatory guidance, so the ISQ offersunbeatable performance in all modes ofanalysis.

No Noise is Good NoiseAchieving lower detection limits using asingle quadrupole GC-MS requires breakingboundaries of noise – chemical noise,electronic noise, and neutral noise.Chemical noise and neutral noise contributeto higher backgrounds and affectdetectability – the ability to distinguish alow-concentration target from noise. TheISQ design reduces chemical and neutralnoise, allowing for lower detection limitsand improved sensitivity.

Excellent Sensitivity– Unparalleled RobustnessEasily meet your required detection limits,and consistently meet them even as youcontinue to run samples. It’s not only abouthow sensitive your system is when it firstarrives, but how long you can continue toachieve your required performance levelsthat is the true measure of productivity.Heated ion optic zones in the ISQ helpensure that the system stays cleaner for alonger period of time.

•Mass range from 1.2-1100 u

•Vacuum interlock for Full-Source Removalwithout venting

•S-Shaped Ion Guide for noise reduction

•ExtractaBrite source for analytical robustnessand flexibility

• Fast acquisition rates compatible withhigh-speed gas chromatography

•Removable cartridge source design for quickmaintenance or to easily change ionizationmodes

•Sequential full scan/SIM for qualitative andquantitative analysis in a single injection

•Dual filament with fine-tuned control forreliable operation

•QuanLab Forms layered application softwarefor easy acquisition, review and reporting ofGC-MS data

Analytical Flexibility

•EI mode for unknown analysis – the standardfor GC-MS acquisitions

•Chemical ionization, including PCI for molecularweight confirmation, NCI for enhancedselectivity and sensitivity, with PPINICI standardfor alternating PCI and NCI scans in a singleinjection

Expanded Capabilities

•Liquid and headspace autosampler options

•DEP/DIP direct sample probes

•Range of injection port options, all with largevolume injection capabilities

•EnviroLab Forms and ToxLab Forms forworkflow-oriented data acquisition, review andreporting according to specific market needs

•Choice of gas chromatographs to match GCperformance to the analytical needs of your lab

•Compatible with additional sample introductiontechniques, such as thermal desorption, purgeand trap and solid phase microextraction (SPME)

ISQ Features

Thermo Scientific ISQ

Single Quadrupole G

C-MS

Full Source Removal for EasyMaintenanceThe ExtractaBrite source incorporates asource cartridge that contains the repeller,lens stack, and RF lens, all of which can beremoved from the instrument while stillunder vacuum. What once took hours, oreven an entire day, is now accomplished inminutes.

The cartridge source allows you tochange ionization modes from electronionization (EI) to chemical ionization (CI) andback again without shutting off your system.Why compromise EI or CI performance usinga source that isn’t optimized for yourionization mode when you can simplychange sources in minutes?

Unique Dual-Filament DesignThe ISQ offers a dual filament for extendedoperation and lifetime. The unique design ofthe filament in the ISQ ensures that bothfilaments offer similar analytical performance.The filaments are oriented in the samedirection for improved performance and areprotected by an electron lens. Your analysesdo not pay a price for switching from onefilament to the next. In addition, filamentcurrent at lower settings is more tightlyregulated, for better accuracy and increaseddynamic range.

Go WirelessThe cartridge source eliminates the hassleof connecting and disconnecting wireswhen maintaining your ion source. Secureelectrical connections with the ion opticsoffer consistent connections, wirelessly.There is no need to inspect the source toconfirm that the wires are in the correctlocation, or to remember which lead goeswhere – just insert the cartridge and go.

S-shaped Ion Guide ReducesExcited Helium NoiseOff-axis optics combined with a uniques-shaped ion guide (SSIG) dramaticallyreduce the effects of excited heliumneutrals reaching the detector by creatinga path that the neutrals cannot navigate.The ISQ offers improved detectivity withoutreducing the available dynamic range of theinstrument and without affecting thespectral data generated.

Design Innovations that Work for YouTapping into advanced technology to streamline day-to-day operations

The ISQ GC-single quadrupole MS has been designed to be at its heart a true workhorse for yourlaboratory. Rugged components, simplified access, and streamlined tool requirements are allincorporated into the ISQ to make the system easy to use, simple to maintain, and ideal for yourGC-MS analysis needs from research to routine.

Noise reduction due to off-axis ion optics

On-Axis (in-line) Optics Off-Axis Optics

noise reducedto ~2 ions/sec

Scan Fast, Across a UsefulMass RangeFast scan rates on a GC-MS system sound good,until you run into analytical limits on the utility ofthese faster scan rates. The ISQ features fastelectronics that write data to disc nearly as fast asit can be acquired, so your applications are limitedmore by the physics of ion flight time, not theinstrument’s electronics. Mass spectra generatedat high scan rates are comparable to those createdat slower scan rates, meaning that you’ll be ableto confidently identify compounds using standardlibrary searching.

Unsurpassed Detector Dynamic RangeThe ISQ detection system was designed to providea broad dynamic range to cover concentrationsthat could vary widely from sample to sample.Within a day’s batch, unknown concentrations canbe either very low, approaching the detectionlimits, or very high, pushing the capability of boththe analytical column and the mass spectrometer.The detection system is modular to facilitate quick,easy, and cost effective replacement of themultiplier element over the life of the instrument.The conversion dynode and associated ion opticsremain a permanent part of the instrument. Onlythe multiplier module is replaced. The mounting isdesigned to insure proper alignment for maximumperformance. The multiplier itself is a discrete-dynode device which enables maximum dynamicrange while reducing noise.

High scan rates for quantitative precision and fast throughput

Excellent analytical linearity reduces re-analysis needs

Wide mass range covers broad application needs

Thermo Scientific ISQ

Single Quadrupole G

C-MS

Lab Forms Software PackagesThe ISQ GC-MS system offers reliable, robustperformance, ideally suited for GC-MSapplications from research to routine. ThermoScientific Lab Forms applications – QuanLabForms, EnviroLab Forms and ToxLab Forms –complement routine GC-MS applications andstreamline your workflows.

Lab Forms Core CapabilitiesThe Lab Forms packages offer common usertools that simplify workflows and make gettingfrom sample to result easier and moreefficient.

Easy Navigation A dashboard guides users to their activities tomove quickly to the desired mode. Configureand customize the application, develop andcreate methods, or focus on daily production toprogram batches, review data, and generatereports.

User Role CapabilitiesOptional user roles allow you to control accessto program settings and functions based on theuser’s job types. This allows simplified routineworkflows and protects methods and datafrom inadvertent changes.

Optimized Data ReviewThe Lab Forms Data Review environment isdesigned to simplify reviewing complex datasets by incorporating easy-to-interpret flags.These flags can highlight data that fallsoutside of your lab’s criteria, allowing you toeasily spot and correct any issues, simply andeasily.

Active ReportingWhere the Lab Forms software packages trulyredefine workflows is with a revolutionaryapproach to data review and reporting.Through powerful Smart Reporting, datareview and data reporting are dynamicallylinked in Active View, allowing for real-timechanges to the reports based on changes tothe data. Any changes to data are immediatelyreflected in the report– no reprocessing, no reanalyzing the data.Manual integrations areflagged for auditingpurposes, so a record iskept of the changesmade to the batch.

Custom ReportsLab Forms software offers the ability to usecustom reporting by creating specialMicrosoft® Excel® reports. These customreports can be automated at a batch or samplelevel, using the same processes as theintegrated standard reports.

Maximize Productivity with Workflow-OrientedSoftware OptionsDesigned for routine GC-MS analyses, to improve efficiency and productivity

Simplified workflows for efficient navigation

Dynamically linked data review and reporting

QuanLab FormsQuanLab Forms comes with your ISQ GC-MSsystem, providing you with a simple tool forroutine GC-MS data acquisition, analysis andreporting. A wide selection of standard, pre-configured reports allows you to easily reportdata in a style that suits your lab’s needs, pluscustomizable reports allow you to tailorreports for your specific applications.Generate reports in real time during sampleacquisition, or review and report data throughthe intuitive Data Review screen.

EnviroLab FormsFor today’s environmental labs, balancing highproductivity and sample throughput withstringent quality controls means that the datareview process is typically a bottleneck inmoving from sample to report. EnviroLabForms follows environmental laboratoryworkflows, with report options tailored to theneeds of environmental laboratories. Becausereviewing environmental data can be very

time-consuming, Smart Reporting streamlinesthis task. Simply double-click out of range orquestionable results, review and fix ifpossible, and you’re done. Manualintegrations are flagged for auditing purposes,and reports are ready to approve and print.Enhanced tools for tentatively identifiedcompounds are included in EnviroLab Forms.

ToxLab FormsToxLab Forms is designed for the clinicalresearch or forensic toxicology laboratory.ToxLab Forms streamlines the path fromunknown sample to known result in a mannerthat is secure, defensible, and aligned withyour lab’s specific needs. Enhancementscustomized for routine toxicology analysis arebuilt into the system. ToxLab Forms providesautomated spectral library searching for non-target peaks and reports semi-quantitativeresults for these unknown compounds.

Xcalibur Data SystemThe Xcalibur data system provides confidentcontrol from method development to reportingusing the ISQ GC-MS system. Xcalibur is alsoused to provide tools for generating andmaintaining your own spectral libraries. It iscompatible with commercial libraries such asNIST, Wiley, Maurer-Pfleger-Weber and others.Xcalibur provides complete control of the TRACEGC Ultra and FOCUS GC, the ISQ massspectrometer and optional liquid or headspaceautosamplers.

Easy Interpretation ofMass Spectral DataMass Frontier software provides a suite ofoptions that allows the MS operator to interpretmass spectral data. This optional softwarepackage assists the operator in structuralidentification, isotope pattern determination,and spectral classifications.

ToxLab Forms Method View

EnviroLab Forms Data review

Thermo Scientific TRACE GC Ultra– The Ideal ISQ PartnerThe TRACE GC Ultra gas chromatograph is afull-performance, full-featured instrumentideal for routine or advanced GC techniques.The TRACE GC Ultra offers an unparalleledrange of injection port options, designed tomeet your sample requirements:• Standard split/splitless for routine sampleanalysis, plus perform large volumesplitless injections with only minormodifications

• Advanced multi-mode programmabletemperature vaporizing inlet (PTV) withPTV mode, constant temperature andavailable large-volume and backflushoptions

• True cold-on-column inlet for ultimate innon-discriminating injections, with fullautomation possible using the ThermoScientific TriPlus AutosamplerThe TRACE GC Ultra also offers the

ability to add a complement of GC detectors:FID, ECD, PID, FPD, NPD, and PDD.

Data for up to two detectors plus theISQ can be automatically acquired andprocessed through the Thermo ScientificXcalibur data system.

Thermo Scientific FOCUS GC– Small in Stature,Big on Performance

The FOCUS GC is equipped with a full-sizedGC oven, compatible with standard GCcolumn cages, yet it takes up a fraction ofthe bench space of the full-sized GCs. ThisGC offers full-sized GC performance, too,with a standard split/splitless injection port.Combined with the ISQ, this creates apowerful GC-MS system ideal for routineapplications in environmental,petrochemical, forensic andQA/QC laboratories

ISQ withFOCUS GC

Thermo Scientific ISQ

Single Quadrupole G

C-MS

Excellence in GC-MS Begins with the GCMatch GC and Autosampler Options to Your Lab’s Needs

The ISQ GC-MS system can be configured with either the FOCUS GC, a single-channel gaschromatograph with a split/splitless injection port or the TRACE GC Ultra gas chromatograph,with a full range of versatile injector and detector options.

ISQ with TRACE GC Ultra

Fast analysis of volatileorganics in drinking water

Thermo ScientificAutosampler OptionsPrecise sample introductions are requiredfor best reproducibility and accuracy.The Thermo Scientific AI/AS 3000 IIautosampler and TriPlus™ autosampler offerideal solutions for automated injections.

TriPlus Autosampler– Flexible Sampling Solutions

With advanced robotic technology andindependent three-dimensional movementof the syringe holder, the TriPlus Autosamplerprovides flexibility in sample capacity andhandling for high lab productivity.

TriPlus AS for liquid samples

• Excellent precision for reproducibleresults

• Capacity for 300 2-mL autosampler vials• Use 50 mm or 80 mm needle lengths• Compatible with large volume injections• Anticipated injection cycles for faster

sample-to-sample times

TriPlus HS for headspace analysis• Excellent for use in volatiles analysis and

solvent detection • Heated syringe-based system minimizes

sample loss• Simplified method development

TriPlus DUO – includes bothheadspace and liquid samplingturrets• Interchangeable turrets provide flexible

configuration depending on analyticalneeds

TriPlus SPME* Option for automatedsolid phase microextraction• Automates sample preparation

and analysis• Excellent for pesticide residue analysis

to minimize initial sample preparation

AI/AS 3000 II Sampler

The AI 3000 II offers a basic configurationfor up to 8 vials at a time, while the AS 3000 II holds 105 standard liquidautosampler vials. Excellent precision andtool-free alignment make this sampler aperfect choice for routine liquid sampleinjections.

TriPlus AS LiquidAutosampler

* Sold under license from Supelco®

AS 3000 IIAutosampler

Sample Handling

• Comprehensive range of vials andclosures

• Mass Spec Certified vials, the onlypre-cleaned chromatography vialavailable

Sample Preparation

• Thermo Scientific HyperSep Retainpolymeric solid phase extraction products

• QuEChERS solutions for efficient samplepreparation and clean-up

• GC derivatization reagents• Reacti-Therm sample derivatization

system

GC Columns and Accessories

• TraceGOLD GC columns• TracePLOT columns – for permanent

gas and light hydrocarbon • GC Consumables• Essential tools and equipment, including

the following:– GLD-Pro Leak Detector– GFM-Pro Electronic Flowmeter

Thermo Scientific ChromatographyColumns and ConsumablesThe perfect partner for optimal analytical performance

Thermo Scientific chromatography columns and consumables are designed to complement our innovativerange of GC and GC-MS systems. Get the most out of the ISQ GC-MS system by pairing it with advanced,high-performance Thermo Scientific products. The wide range of consumables and accessories offercustomers applications-focused solutions in the environmental, food analysis, forensics/toxicology,petrochemical, pharmaceutical and general analytical industries.

Columns and Consumables

Chemical Ionization forRoutine UseChemical ionization using reagent gases isone tool for increasing the selectivity ofsingle quadrupole GC-MS analyses.However, this technique is not often appliedto routine applications due to its apparentcomplexity. The ISQ allows you to tap intothe utility of chemical ionization, easily, toincorporate it into routine analyticalapplications.

Plumb two reagent gases into thesystem, with software selection of thereagent gas inside your instrument method.Optimize methods for two different reagentgases, and switch easily between themwithout any manual modifications to thesystem.

Change from chemical ionization toelectron ionization and back without ventingyour mass spectrometer using the standardvacuum interlock feature. Acquire positiveand negative ion chemical ionization resultsin a single injection using Thermo Scientificproprietary Pulsed Positive Ion Negative IonChemical Ionization (PPINICI™) capability,standard with chemical ionization on theISQ system.

Oil-Free Pump for CleanEnvironmentsAn available oil-free pump preferable forclean environments is available for theISQ system. Eliminate oil changes andcostly disposal of used pump oil with thesystems's dry pump option, also suitablefor use with ammonia reagent gas.

Direct Sample Probe for Analysiswithout the Gas ChromatographPerform quick characterizations of liquid orsolid samples without using the gaschromatograph by employing a DirectSample Probe. The Direct Sample Probeallows you to use either a micro-crucibleapproach to more slowly volatilize yoursample (Direct Insertion Probe), or use afilament to rapidly heat the sample for aquicker volatilization (Direct ExposureProbe). Both are easily performed on theISQ, all without venting the system. Plus,the GC remains in place, allowing you theflexibility to switch between traditional gaschromatography and the direct sampleprobe approach.

Easy to Use for Routine Applications,with Advanced Options for ResearchBreak detection limit barriers

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Specifications, terms and pricing are subject to change.Not all products are available in all countries. Pleaseconsult your local sales representative for details.

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extends its support throughout our worldwide network of highly trained and certified

engineers who are experts in laboratory technologies and applications. Put our team

of experts to work for you in a range of disciplines – from system installation, training

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consulting. Improve your productivity and lower the cost of instrument ownership

through our product support services. Maximize uptime while eliminating the

uncontrollable cost of unplanned maintenance and repairs. When it’s time to

enhance your system, we also offer certified parts and a range of accessories and

consumables suited to your application.

To learn more about our products and comprehensive service offerings,

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