The world leader in serving science

UBS West Coast

Life Science Bus Tour

San Jose, CA

March 25, 2009

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� Company Overview

Kenneth Apicerno, Vice President, Investor Relations

� Technology Overview

Ian Jardine Ph.D., Vice President, Global Research & Development

� Factory Tour

Mark Chatfield, High Performance Liquid Chromatography (HPLC) Cell Manager

Agenda

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Company Snapshot

� $10.5 billion in revenue

� 34,000 employees in 40 countries

� 350,000 customers

� 150 countries served

� #269 on Fortune 500

Clear industry leadership

4

An Attractive Profile…

Global ReachMarket StrengthBalanced Mix

Asia,

ROW

13%

North America

61%

Europe

26%

Healthcare

22%

Life Science

46%Environmental,

Industrial

& Safety

32%

…to meet diverse needs of global customers

Services

16%

Consumables

49%Instruments

& Equipment

30%

5%

Software

5

Two Distinct Business Segments

Analytical Technologies Segment

Laboratory Products and Services Segment

Unmatched combination of technology breadthand purchasing convenience

41% 59%

� Innovative technologies

geared toward the

scientist and engineer

� Focused on providing

integrated workflows

� Growth platforms:

• Analytical Instruments

• Specialty Diagnostics

• Biosciences

� Providing customers

easy access to routine

laboratory products and

services

� Focused on complete

product offerings and

outsourced services

� Growth platforms:

• Laboratory Products

• Customer Channels

• Biopharma Services

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Analytical Technologies at Glance

Analytical InstrumentsRevenue: $2.5B

� Instruments and software:

• Mass spectrometry

• Chromatography

• Molecular spectroscopy

• Elemental analysis

• LIMS and lab software

�Moving technologies outside the laboratory

� Scientific Instruments

� Environmental Instruments

� Process Instruments

Key Capabilities

BiosciencesRevenue: $0.7B

� Life Science Research

� Bioprocess Production

� Laboratory Chemicals

Key Capabilities

� High-end reagents for life science research:

• RNAi technologies

• Proteomics workflows

� High content screening kits, cellular protein pathways, cell culture products

� Leader in disposable bioprocess products for biotech manufacturing

� Microbiology

� Immunoassay

� Molecular Diagnostics

� Anatomical Pathology

Specialty DiagnosticsRevenue: $1.3B

Key Capabilities

� Integrated workflow solutions for highly specialized diagnostic tests:

• Drugs of abuse testing

• MRSA infection

• Cancer detection

• Organ transplantation

• Genetic testing

Revenue numbers before inter-company eliminations

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Laboratory Products and Services at Glance

Laboratory ProductsRevenue: $1.9B

� Equipment:

• Sample preparation

• Separation

• Controlled environment

� Liquid handling solutions

� Plastic and glass consumables

� Laboratory furniture and design

� Laboratory Equipment

� Laboratory Consumables

� Laboratory Workstations

Key Capabilities

Customer Channels

Revenue: $4.3B

� Research Catalog

� Healthcare Catalog

� Safety Catalog

Key Capabilities

� Unparalleled customer access

� Research: World leading resource for lab equipment and consumables

� Healthcare: Premier diagnostic test catalog for hospitals, reference labs and physicians’ offices

� Safety: Occupational health and safety products

� Clinical Trials Logistics

� Analytical Services

Biopharma ServicesRevenue: $0.7B

Key Capabilities

� Logistics services for clinical trials:

• Package, label, ship, store

� Biological specimen archiving and management

� Controlled drug storage and distribution

Revenue numbers before inter-company eliminations

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Agenda

� Company Overview

Kenneth Apicerno, Vice President, Investor Relations

� Technology Overview

Ian Jardine Ph.D., Vice President, Global Research & Development

� Factory Tour

Mark Chatfield, High Performance Liquid Chromatography (HPLC) Cell Manager

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Healthcare Funding in the News

� Recovery & Reinvestment Act of 2009 (Stimulus Bill)

• $10.4B one-time boost to NIH budget

• $3B one-time boost to National Science Foundation

� Obama’s Current Budget Proposal

• $6B one-time increase in NIH funding for cancer research

• $1B increase to 2009 NIH budget (now $30.3B)

• $1B to FDA to support food safety efforts

Increased opportunities in healthcare

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Stem Cell Research

� Stem Cell Research is aimed at regenerating damaged tissues such as bone loss, nerve damage and replacement of dysfunctional cells

� Opportunity to treat diseases such as Alzheimer’s, Parkinson’s, Type 1 Diabetes and blood cancers

� Current administration expected to open up federal funding in the U.S. (included within stimulus package)

� Over $14b of U.S. investment expected over next ten years from state and private funding and expected to grow at 9% through 2015

Stem cell research promises to fill gaps where current methods fall short

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Stem Cell Research - Integrated Workflow Solutions

Key elements combined to assure stability and reproducibility

� Offering qualified culture ware, media and controlled environment that stem cells need in order to grow and multiply in a predictable way

� Technology to allow researchers to completely monitor, control and analyze stem cell growth

� Detection technology to ensure the quality of the final cell type, whether for therapeutics or for drug development

Culture Ware

Cell Lines

Media

Cell Imaging

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� Proteins: basic components of all living cells and regulate how our bodies function

� Scientists working diligently to identify proteins

• i.e.: ~10,000 proteins in our blood, and only about 3,000 can be detected today

� Understanding of proteins is critical for developing effective drug treatments

� Identifying the difference in proteins and protein levels in one patient versus another

• Leading to personalized medicine and companion diagnostics

� Biomarker identification to enable the development of better diagnostic tests

Protein Research

Protein biomarkers are key indicators of disease

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Protein Research – Mass Spectrometry

Thermo Fisher Scientific is leading the way in advancing protein science

� Mass spectrometry is the instrument of choice to identify protein biomarkers

� Speed, resolution and accuracy are all improving rapidly

� Offering scientists complete workflow solutions … instruments, reagents, consumables

and software

Accelerating Time to Identify 1 Protein

2004

1 Every

30 seconds

2006

1 Every

3 seconds

20081 Every 3/10ths

of a second

Before 1990

1 Every

Year

Next1 Every 3/100ths

of a second

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RNAi Technology

RNAi research advancing drug discovery

� RNA interference (RNAi) silences a gene and prevents that gene from producing its protein product

• Nobel Prize winning technology developed in 1998

� Research opportunity:

Scientists are able to independently manipulate genes and evaluate the consequences to cells by silencing certain genes

� Therapeutic opportunity:

Scientists are able to silence a gene and identify those gene products that are suitable as drug targets – they can now target “cancer” causing genes

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RNAi Technology – Reagents and Services

Most comprehensive portfolio of RNAi-based reagents and services

Industry leading products

� Pre-designed libraries of silencing reagents (siRNA, shRNA, and miRNA)

� Screening and profiling services for researchers

� mRNA and protein detection reagents

� Custom reagents for RNAi research

Automated RNAi screening

� Integrated instrumentation and robotics for cell growth and analysis

� Performs high throughput screens using RNAi based reagents

� Standardizes process to maximize efficiency

RNAi discovery services

� Provides RNAi-based high-throughput screening and analysis

� Conducting whole genome wide screens that help identify drug target

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Pittcon 2009: New Products for Key Applications

Data Interpretation

Sample Analysis

Sample Preparation

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Pittcon 2009: New Products for Sample Preparation

Protein Catalogs

Electrodes

Meters

siRNA, shRNA, miRNABioreagents

Hamilton Infinity Fume Hood

Hamilton Distinction II Green Lab Furniture

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New Thermo Scientific Products for Sample Analysis

Accela Exactive™ LCMS

TSQ Vantage™

Niton XRF GOLDD™Titan 4000™

NSX Analyzer

Basic

Research

Drug Discovery

& DevelopmentEnvironmental &

Food Screening

Industrial &

Product TestingPetroleum &

Chemical

Arena™

Chemistry Analyzer

A range of innovations, from research to routine testing

NanoDrop™

2000/2000cUV/Vis

R

Transcend TLX™ Access Max™

LCMS

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The Value of High Mass Accuracy and Ultrahigh Resolution

The Case for Exactive

A mixture of >100 pesticides,

mycotoxins and veterinary

drugs at different concentration

levels in horse feed matrix

analyzed at two resolution

settings utilizing full scan

accurate mass measurements

(+/- 2ppm)

100k

10K

0 20 40 60 80 100

250

50

10

% Detected

Detected compounds ppm

45%

10K resolution can’t detect known chemicals

Vastly superior analytical results with Orbitrap performance

99%

100%

93%

32%

11%

250

10

The power of 100K resolution

Orbitrap

ToF

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Orbitrap Technology for Routine Screening Applications

Exactive will displace ToFs and QToFs!TM

Thermo Scientific Exactive

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Pittcon 2009: New Data Interpretation Solutions

OMNIC Specta on Raman

Pathfinder TraceFinder

Enterprise Insights

Connects

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The World Leader in Serving Science

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Agenda

� Company Overview

Kenneth Apicerno, Vice President, Investor Relations

� Technology Overview

Ian Jardine Ph.D., Vice President, Global Research & Development

� Factory Tour

Mark Chatfield, High Performance Liquid Chromatography (HPLC) Cell Manager

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San Jose LC/MS Products

3D and Linear Ion-traps

LTQ-ETD

Triple Quads

LTQ FTMS

LTQ OrbitrapSurveyor HPLCAccela UHPLC

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The World Leader in Serving Science

We are the leading provider of analytical instruments,

equipment, reagents and consumables, software and services

for research, analysis, discovery and diagnostics.

Thank you!