Theise Upaya 2 2008
-
Upload
neil-theise -
Category
Spiritual
-
view
987 -
download
1
description
Transcript of Theise Upaya 2 2008
Bushell & Theise
Zen Body, Yogic HealingZen Body, Yogic Healing
William C. Bushell, PhDMIT and Tibet House (Director of East/West Studies)
New York City
Neil Soten Theise, MDDepts. Of Pathology and Medicine
Beth Israel Medical Center – Albert Einstein College of MedicineNew York City
Bushell & Theise
Put group portrait from menla conference HERE
Bushell & Theise
What kind of models?
Bushell & Theise
for example,2 models from Ancient Greece:
Is the body made of… indivisible subunitsindivisible subunits or an endlessly divisible fluidan endlessly divisible fluid
Bushell & Theise
Bushell & Theise
Bushell & Theise
Bushell & Theise
Bushell & Theise
Models of the body are perspective/technique dependent
Look at it this way (cell membranes): the body is made of cells
Look at it that way (organelles): the body is an endlessly divisible fluid
Bushell & Theise
Models are perspective/technique dependent
Look at it this way (cell membranes): the body is made of cells
Look at it that way (organelles): the body is an endlessly divisible fluid
Yet another way (the genome):… overlapping spatial/temporal fields of molecular
organization
Bushell & Theise
Put group portrait from menla conference HERE
Bushell & Theise
““There’s no such thing as a central There’s no such thing as a central dogma into which everything will dogma into which everything will fit...any mechanism you can think of, fit...any mechanism you can think of, you will find -- even if it is the most you will find -- even if it is the most bizarre kind of thinking. bizarre kind of thinking.
““Anything... Anything...
““So if the material tells you, ‘It may So if the material tells you, ‘It may be this,’ allow that. Don’t turn it aside be this,’ allow that. Don’t turn it aside and call it an exception, an aberration, and call it an exception, an aberration, a contaminant.a contaminant.
“ “So many good clues have been lost So many good clues have been lost that way.“that way.“
“A Feeling for the Organism”Evelyn Fox Keller, 1983
Nobel-laureate Barbara McClintock:Nobel-laureate Barbara McClintock:
Bushell & Theise
regeneration
aging
longevity
protection
Bushell & Theise
regeneration
Bushell & Theise
regeneration
tissue repair & restitutionfollowing cell loss or injury
Bushell & Theise
regeneration
longevity
Bushell & Theise
regeneration
aging
longevity
Bushell & Theise
regeneration
aging
longevity
protection
Bushell & Theise
regeneration
aging
longevity
protection
Bushell & Theise
GLOBAL/SYSTEMIC interventions
Bushell & Theise
Cognitive
Behavioral
Practices
GLOBAL/SYSTEMIC interventions
Bushell & Theise
Cognitive(mindfulness, visualization, analytical etc.)
Behavioral
Practices
GLOBAL/SYSTEMIC interventions
Bushell & Theise
Cognitive(e.g. mindfulness, contemplative)
Behavioral(e.g. prostrations, yoga asanas, pranayama, caloric restriction)
Practices
GLOBAL/SYSTEMIC interventions
Bushell & Theise
Cognitive(e.g. mindfulness, contemplative)
Behavioral(e.g. prostrations, yoga asanas, pranayama, caloric restriction)
Practices
GLOBAL/SYSTEMIC interventions
LOCAL effects
Bushell & Theise
Cognitive (e.g. mindfulness, contemplative)
Behavioral (e.g. prostrations, yoga asanas, pranayama, caloric restriction)
Practices
GLOBAL/SYSTEMIC interventions
LOCAL effects
Site Specific, Tissue Regeneration
Bushell & Theise
Cognitive(e.g. mindfulness, contemplative)
Behavioral(e.g. prostrations, yoga asanas, pranayama, caloric restriction)
Practices
GLOBAL/SYSTEMIC interventions
LOCAL effects
e.g.Stabilization of stem cell niche and stem cell integrity
Proliferation and organization of repopulating cellsInhibition of scar formation
Site Specific, Tissue Regeneration
Bushell & Theise
Cognitive(e.g. mindfulness, contemplative)
Behavioral(e.g. prostrations, yoga asanas, pranayama, caloric restriction)
Practices
GLOBAL/SYSTEMIC interventions
LOCAL effects
e.g.Stabilization of stem cell niche and stem cell integrity
Proliferation and organization of repopulating cellsInhibition of scar formation
Humoral factors Nerve signaling Bioelectromagnetism Cell trafficking
Site Specific, Tissue Regeneration
Bushell & Theise
Cognitive(e.g. mindfulness, contemplative)
Behavioral(e.g. prostrations, yoga asanas, pranayama, caloric restriction)
Practices
GLOBAL/SYSTEMIC interventions
LOCAL effects
e.g.Stabilization of stem cell niche and stem cell integrity
Proliferation and organization of repopulating cellsInhibition of scar formation
Humoral factors
Site Specific, Tissue Regeneration
Bushell & Theise
Cognitive(e.g. mindfulness, contemplative)
Behavioral(e.g. prostrations, yoga asanas, pranayama, caloric restriction)
Practices
GLOBAL/SYSTEMIC interventions
LOCAL effects
e.g.Stabilization of stem cell niche and stem cell integrity
Proliferation and organization of repopulating cellsInhibition of scar formation
e.g. Melatonin!!
Site Specific, Tissue Regeneration
Bushell & Theise
Cognitive(e.g. mindfulness, contemplative)
Behavioral(e.g. prostrations, yoga asanas, pranayama, caloric restriction)
Practices
GLOBAL/SYSTEMIC interventions
LOCAL effects
e.g.Stabilization of stem cell niche and stem cell integrity
Proliferation and organization of repopulating cellsInhibition of scar formation
e.g. Melatonin!!
Bushell & Theise
Bushell & Theise
Bushell & Theise
Abbasoglu O et al, 1995. The effect of the pineal gland On liver regeneration in rats, J Hepatology 23: 578-81.
Bellipanni G et al, 2005. Effects of melatonin in perimenopausal and menopausal women: our personal experience, Annals of the NY Academy of Sciences 1057: 393-402Bubenik GA, 2002. Gastrointestinal melatonin: localization, function,
and clinical relevance, Digestive Disease Science 47: 2336-48.
Castagnino HE et al, 2002. Cytoprotection by melatonin and growth hormone in early ratmyocardial infarction as revealed by Feulgen DNA staining, Neurology Endocrinology Letters 23(5-6): 391-5.
Conti et al, 2000. Evidence for melatonin synthesis in mouse and human bone marrow cells.J Pineal Res. 2000 May;28(4):193-202.Csaba G, 1993. Presence in and effects of pineal indoleamines at very low level of phylogeny, Experientia 49: 627-34.
Danilova N et al, 2004. Melatonin stimulates cell proliferation in zebrafish embryo and accelerates its development, FASEB J 18: 751-3.
Dundar K et al, 2005. Protective effects of exogenously administered or endogenously produced melatonin on hyperbaric oxygen-induced oxidative stress in the rat brain, Clinical & Experimental Pharmacology and Physiology 32(11): 926-30. Erkanli K et al, 2005. Melatonin protects against
ischemia/reperfusion injury in skeletal muscle, J Pineal Research 39(3): 238-42.Escames G et al, 2006. Melatonin counteracts inducible mitochondrial nitric oxide synthase-dependent mitochondrial dysfunction in skeletal muscle of septic mice, J Pineal Research 40(1): 71-8.
Esrefoglu M et al, 2005. Potent therapeutic effect of melatonin on aging skin in pinealectomized rats, J Pineal Research 39(3): 231-7.
Feng Z et al, 2006. Early melatonin supplementation alleviates oxidative stress in a transgenic mouse model of Alzheimer’s disease, Free Radicals in Biology & Medicine 40(1): 101-9.
Girotti L et al, 2003. Low urinary 6-sulfatoxymelatonin levels in patients with severe congestive heart failure, Endocrine 22(3): 245-8. Karasek M, 2004. Melatonin, human aging, and age-related diseases, Experimental Gerontology 39(11-12): 1723-9.
Kobayashi H, et al, 2005. A role of melatonin in neuroectodermal-mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptors.FASEB J. 2005 Oct;19(12):1710-2.
Lesnikov VA & Pierpaoli W, 1994. Pineal cross-transplantation (old-to-young and young-to-old) as evidence for an endogenous “aging clock” Annals of the NY Academy of Sciences 719: 456-60.
Maestroni GJM et al, 1988. Pineal melatonin, its fundamental immunoregulatory role in aging and cancer, Annals of the NY Academy of Sciences 521: 140-8.
Pierpaoli W, 1998. Neuroimmunomodulation of aging: a program in the pineal gland Annals of the NY Academy of Sciences 840: 491-7. Pierpaoli & Maestroni GJM, 1987. Melatonin: a principal neuroimmunoregulatory and anti-stress hormone: its antiaging effects, Immunology Letters 16: 355-62.Sainz RM et al, 2003. Melatonin and cell death: differential actions on normal and cancer cells, Cellular & Molecular Life Science 60: 1407-26.
Slominski A, et al, 2005. On the role of melatonin in skin physiology and pathology. Endocrine. 2005 Jul;27(2):137-48.
MELATONINMELATONIN
Bushell & Theise
Effects of Melatonin
Cytoprotection
Bushell & Theise
Effects of Melatonin
Cytoprotection
Regeneration
Bushell & Theise
Effects of Melatonin
Cytoprotection
Regeneration
Oncostasis
Bushell & Theise
Bushell & Theise
Bushell & Theise
Effects of Melatonin
Cytoprotection
Regeneration
Oncostasis
Longevity…?
Bushell & Theise
Bushell & Theise
Other MoleculesModulated in Meditation,
e.g.
Arginine vasopressin
DHEA
Nitric Oxide
Bushell & Theise
Cognitive(e.g. mindfulness, contemplative)
Behavioral(e.g. prostrations, yoga asanas, pranayama, caloric restriction)
Practices
GLOBAL/SYSTEMIC interventions
LOCAL effects
e.g.Stabilization of stem cell niche and stem cell integrity
Proliferation and organization of repopulating cellsInhibition of scar formation
Humoral factors Cell trafficking
Site Specific, Tissue Regeneration
Bushell & Theise
Cognitive(e.g. mindfulness, contemplative)
Behavioral(e.g. prostrations, yoga asanas, pranayama, caloric restriction)
Practices
GLOBAL/SYSTEMIC interventions
LOCAL effects
e.g.Stabilization of stem cell niche and stem cell integrity
Proliferation and organization of repopulating cellsInhibition of scar formation
Humoral factors Cell traffickingNerve signaling
Site Specific, Tissue Regeneration
Bushell & Theise
Neil’s stuff #2
Bushell & Theise
Cognitive(e.g. mindfulness, contemplative)
Behavioral(e.g. prostrations, yoga asanas, pranayama, caloric restriction)
Practices
GLOBAL/SYSTEMIC interventions
LOCAL effects
e.g.Stabilization of stem cell niche and stem cell integrity
Proliferation and organization of repopulating cellsInhibition of scar formation
Humoral factors Cell traffickingNerve signaling
Site Specific, Tissue Regeneration
Bushell & Theise
Bill’s stuff #2
Bushell & Theise
Bill’s stuff #2NOT ONLY!
Bushell & Theise
A MIND – BODY CONNECTIONnerves connect to liver stem cells
Bushell & Theise
Yogic Practicesand the Vagus
Meditation
Bushell & Theise
Yogic Practicesand the Vagus
Meditation
Mantrayana
Bushell & Theise
Yogic Practicesand the Vagus
Meditation
Mantrayana
Pranayama
Bushell & Theise
Yogic Practicesand the Vagus
Meditation
Mantrayana
Pranayama
Asana
Bushell & Theise
Cognitive(e.g. mindfulness, contemplative)
Behavioral(e.g. prostrations, yoga asanas, pranayama, caloric restriction)
Practices
GLOBAL/SYSTEMIC interventions
LOCAL effects
e.g.Stabilization of stem cell niche and stem cell integrity
Proliferation and organization of repopulating cellsInhibition of scar formation
Humoral factors Nerve signaling Bioelectromagnetism Cell trafficking
Bushell & Theise
Bioelectromagnetism
Definitions!
Bushell & Theise
Bioelectromagnetism
NOT necessarily“energy” or “chi” or or or or or…
Bushell & Theise
Bioelectromagnetism
Electron or ionic flux
Bushell & Theise
Bioelectromagnetism
Electron or ionic flux
Nerveconduction Tissue
flux
Molecularlevel
(DNA)
Bushell & Theise
Bioelectromagnetism
Electron or ionic flux
Nerveconduction Tissue
flux
Molecularlevel
(DNA)
Bushell & Theise
Bushell & Theise
Bushell & Theise
Bushell & Theise
Cognitive(e.g. mindfulness, contemplative)
Behavioral(e.g. prostrations, yoga asanas, pranayama, caloric restriction)
Practices
GLOBAL/SYSTEMIC interventions
LOCAL effects
e.g.Stabilization of stem cell niche and stem cell integrity
Proliferation and organization of repopulating cellsInhibition of scar formation
Humoral factors Nerve signaling Bioelectromagnetism Cell trafficking
Site Specific, Tissue Regeneration
Bushell & Theise
Bushell & Theise
Nerves
Cell Trafficking
Humoral factors
Bioelectomagnetic
Bushell & Theise
Nerves
Cell Trafficking
Humoral factors
Bioelectomagnetic
Yoga Asanas
Chi Kung
Acupuncture
Pranayama
Meditation
Bushell & Theise
Macroscopic body
Microscopic body
Nanoscopic body
Quantum body
Bushell & Theise
Macroscopic body
Microscopic body
Nanoscopic body
Quantum body
e.g. physical therapysurgery
e.g. cell therapies
e.g. molecular medicineantibiotics
e.g. electromagnetics
Bushell & Theise
Macroscopic body
Microscopic body
Nanoscopic body
Quantum body
e.g. yogatai chi
e.g. acupuncture?
e.g. traditional remedies
e.g. energy healing?meditation?
Bushell & Theise
Macroscopic body
Microscopic body
Nanoscopic body
Quantum body
CoarseBody
?
EnergyBody
?
SubtleBody
?
Indo-Tibetan Medicine/Physiology
Bushell & Theise
Macroscopic body
Microscopic body
Nanoscopic body
Quantum body
CoarseBody
?
EnergyBody
?
SubtleBody
?
Indo-Tibetan Medicine/Physiology
Bushell & Theise
From the global to the local:Pathways for the transduction of Indo-Sino-Tibetan
cognitive behavioral practices into site specific, tissue regenerative effects.
William C Bushell & Neil D. Theise
Beyond cell doctrine:Complexity thery informs alternate models of the bdy
For cross cultural dialogue
Neil D. Theise
www.neiltheise.com
Bushell & Theise