The wonderful duplicating “machine” A briefe history of the cell cycle 18xx Interphase-Mitosis...
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Transcript of The wonderful duplicating “machine” A briefe history of the cell cycle 18xx Interphase-Mitosis...
A briefe history of the cell cycle
• 18xx Interphase-Mitosis (Flemming)
• 1951 Discovery of a distinct S-phase (Howard and Pelc)
• 1970 Cell fusion experiments (Rao and Johnson)
• 1971 Discovery of MPF (Masui and Markert)
• 197x Yeast cdc mutants (Nurse, Hartwell etc.)
• 1983 Discovery of the first cyclins (Hunt)
• 1988 Cyclin B+cdc2 = MPF (Maller, Newport, Beach)
• 18xx Interphase-Mitosis (Flemming)
• 1951 Discovery of a distinct S-phase (Howard and Pelc)
• 1970 Cell fusion experiments (Rao and Johnson)
• 1971 Discovery of MPF (Masui and Markert)
• 197x Yeast cdc mutants (Nurse, Hartwell etc.)
• 1983 Discovery of the first cyclins (Hunt)
• 1988 Cyclin B+cdc2 = MPF (Maller, Newport, Beach)
• 18xx Interphase-Mitosis (Flemming)
• 1951 Discovery of a distinct S-phase (Howard and Pelc)
• 1970 Cell fusion experiments (Rao and Johnson)
• 1971 Discovery of MPF (Masui and Markert)
• 197x Yeast cdc mutants (Nurse, Hartwell etc.)
• 1983 Discovery of the first cyclins (Hunt)
• 1988 Cyclin B+cdc2 = MPF (Maller, Newport, Beach)
• 18xx Interphase-Mitosis (Flemming)
• 1951 Discovery of a distinct S-phase ()
• 1970 Cell fusion experiments (Rao and Johnson)
• 1971 Discovery of MPF (Masui and Markert)
• 197x Yeast cdc mutants (Nurse, Hartwell etc.)
• 1983 Discovery of the first cyclins (Hunt)
• 1988 Cyclin B+cdc2 = MPF (Maller, Newport, Beach)
• 18xx Interphase-Mitosis (Flemming)
• 1951 Discovery of a distinct S-phase (Howard and Pelc)
• 1970 Cell fusion experiments (Rao and Johnson)
• 1971 Discovery of MPF (Masui and Markert)
• 197x Yeast cdc mutants (Nurse, Hartwell etc.)
• 1983 Discovery of the first cyclins (Hunt)
• 1988 Cyclin B+cdc2 = MPF (Maller, Newport, Beach)
• 18xx Interphase-Mitosis (Flemming)
• 1951 Discovery of a distinct S-phase (Howard and Pelc)
• 1970 Cell fusion experiments (Rao and Johnson)
• 1971 Discovery of MPF (Masui and Markert)
• 197x Yeast cdc mutants (Nurse, Hartwell etc.)
• 1983 Discovery of the first cyclins (Hunt)
• 1988 Cyclin B+cdc2 = MPF (Maller, Newport, Beach)
• 18xx Interphase-Mitosis (Flemming)
• 1951 Discovery of a distinct S-phase (Howard and Pelc)
• 1970 Cell fusion experiments (Rao and Johnson)
• 1971 Discovery of MPF (Masui and Markert)
• 197x Yeast cdc mutants (Nurse, Hartwell etc.)
• 1983 Discovery of the first cyclins (Hunt)
• 1988 Cyclin B+cdc2 = MPF (Maller, Newport, Beach)
• 18xx Interphase-Mitosis (Flemming)
• 1951 Discovery of a distinct S-phase (Howard and Pelc)
• 1970 Cell fusion experiments (Rao and Johnson)
• 1971 Discovery of MPF (Masui and Markert)
• 197x Yeast cdc mutants (Nurse, Hartwell etc.)
• 1983 Discovery of the first cyclins (Hunt)
• 1988 Cyclin B+cdc2 = MPF (Maller, Newport, Beach)
Cdc2/28 (=cdk1) is regulated by:
1. Binding of a cyclin2. Inhibitory phosphorylation3. Activating phosophorylation4. Binding of CKI5. Cellular localization