The Visible Human The Visible Human ProjectProject

"The Visible Human Project includes "The Visible Human Project includes digitized photographic images for digitized photographic images for

cryosectioning, digital images derived cryosectioning, digital images derived from computerized tomography and digital from computerized tomography and digital magnetic resonance images of cadavers."magnetic resonance images of cadavers."

The Visible Human The Visible Human ProjectProject

1.1. Find a Find a normalnormal male and female cadaver male and female cadaver2.2. Fresh CT & MRFresh CT & MR3.3. Fill blood vessels and cavities with contrast mediaFill blood vessels and cavities with contrast media4.4. Pose and stabilize in opaque gelPose and stabilize in opaque gel5.5. Freeze the cadaverFreeze the cadaver6.6. Cut cadaver into blocksCut cadaver into blocks7.7. Frozen CTFrozen CT8.8. Grind down block and take photographGrind down block and take photograph

Infuse blood vessels and fill cavities Infuse blood vessels and fill cavities with contrast media (resin)with contrast media (resin)

Cryo-section Data CollectionCryo-section Data Collection

Data CollectionData Collection

Data CollectionData Collection

CT (bone) MRI (proton-density)

MRI (T1) MRI (T2)

Data CollectionData Collection

• Photographic cross-sections: Volume Dimensions: 1760 x 1024 x 1878Pixel Dimensions: .33 mm x .33 mm x 1 mmPixel Depth: 24-bit (8-bits x RGB)Volume Size: 9.5 GB

• Computed Tomography (CT) - in fresh state: Volume Dimensions: 512 x 512 x 500Pixel Dimensions: variable x variable x 1 mmPixel Depth: 16-bitVolume Size: 250 MB

• Computed Tomography (CT) – in frozen state:Volume Dimensions: 512 x 512 x 1878Pixel Dimensions: variable x variable x 1 mmPixel Depth: 16-bitVolume Size: 939 MB

Data CollectionData Collection

• Photographic cross-sections: Volume Dimensions: 1664 x 928 x 5189 Pixel Dimensions: .33 mm x .33 mm x .33 mm Pixel Depth: 24-bit (8-bits x RGB) Volume Size: 22.4 GB

• Computed Tomography (CT) - in fresh state: Volume Dimensions: 512 x 512 x 1730 Pixel Dimensions: variable x variable x 1 mm Pixel Depth: 16-bit Volume Size: 864 MB

Data CollectionData Collection

Transverse Coronal Sagittal

The Visible HumanThe Visible Human

Segmentation and ClassificationSegmentation and Classification

Semi-automatic SegmentationSemi-automatic Segmentation

Marr-Hildreth edge detection filter, seed filling and neighbor connectivity filter

Spline interpolation of surface

Mostly done by anatomists using a drawing and filtering program.

SegmentationSegmentation

ClassificationClassification

ClassificationClassification

ClassificationClassification