The Use of WinNonlin for Determining Basic Pharmacokinetic...
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The Use of WinNonlin for The Use of WinNonlin for Determining Basic Determining Basic Pharmacokinetic Pharmacokinetic
ParametersParameters
By Christopher J. Kemper, Ph.D.By Christopher J. Kemper, Ph.D.PharmaPharma Navigators, LLCNavigators, LLC
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OverviewOverview
Basic concepts in Pharmacokinetics Basic concepts in Pharmacokinetics and the Big 7and the Big 7The origins of The origins of NonlinNonlin•• Citrix space Citrix space
Available manuals and publicationsAvailable manuals and publicationsStep by step processing of a sample Step by step processing of a sample data setdata set
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Pharmacokinetic Parameters: Pharmacokinetic Parameters: Non CompartmentalNon Compartmental
CCmaxmax, , TTmaxmax, AUC, AUC•• AUC = AUC = ∫∫ C C dtdt
Dose/AUC = Dose/AUC = ClClsyssys = = Vol_DistVol_Dist x x λλzz
HalflifeHalflife = 0.693 / = 0.693 / λλzz
MRT = AUMC/AUCMRT = AUMC/AUC•• AUMC = AUMC = ∫∫ tCtC dtdt•• The mean residence time represents the The mean residence time represents the
time for 63.2% of the dose to be time for 63.2% of the dose to be eliminatedeliminated
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