The State of Dravet Syndrome - Elsevier CME...Comprehensive Epilepsy Center Assistant Professor of...
Transcript of The State of Dravet Syndrome - Elsevier CME...Comprehensive Epilepsy Center Assistant Professor of...
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The State of Dravet Syndrome in 2017 Linda C. Laux, MD
Medical Director
Comprehensive Epilepsy Center
Assistant Professor of Pediatrics
Northwestern University
Feinberg School of Medicine
Chicago, Illinois 2 2
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The State of Dravet Syndrome in 1978
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Les épilepsies graves de l'enfant
Dravet C. Vie Médicale. 1978;8:543-548.
Charlotte Dravet, MD. Pictured above in 1978.
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The State of Dravet Syndrome Since 1978
Seizures
Gait
Cognition
EEG Treatment
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SCN1A
5 Baulac S et al. Am J Hum Genet. 1999;65(4):1078-1085; Escayg A et al. Nat Genet. 2000;24(4):343-345; Claes L et al. Am J Hum Genet.
2001;68(6):1327-1332.
A second locus for familial generalized epilepsy with febrile seizures plus maps to chromosome 2q21-q33.
Mutations of SCN1A, encoding a neuronal sodium channel, in 2 families with GEFS+2.
De novo mutations in the sodium-channel gene SCN1A cause severe myoclonic epilepsy of infancy.
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RESEARCH
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Dravet Syndrome
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Dravet Syndrome: Characteristics, Comorbidities, and Caregiver Concerns
A Dravet Syndrome Foundation (DSF) Survey NICOLE VILLAS, MEd BOARD PRESIDENT
DRAVET SYNDROME FOUNDATION CHERRY HILL, NEW JERSEY
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Disclosures
Parent of a child with Dravet syndrome
Child is enrolled in clinical trial of fenfluramine: NCT02826863
No financial disclosures
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Survey Design
Designed and distributed by Dravet Syndrome Foundation
Posted in Support Group (1600 members)
Link sent to ~4000 email addresses
Likert scales, lists, multiple choice, open response
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Demographics – 256 responses
0
20
40
60
80
100
Re
spo
nd
en
ts (
n)
Patient Age
70% from United States
92% SCN1A+ 6% inherited
(CI = 5.4)
Villas N et al. Epilepsy Behav. 2017;74:81-86. 11
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Patient Characteristics
Comorbidities
Characteristics, Comorbidities, and the Patient
• Gait • Cognitive
Impairment • Speech Delay
• Temperature Dysregulation
• Nocturnal Seizures • Autistic Traits
• Sleep Issues • Frequent
Infections • Behavior
• Blood Abnormalities
• Psychiatric Issues
12 Villas N et al. Epilepsy Behav. 2017;74:81-86.
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Characteristics/Comorbidities by Age
0
20
40
60
80
100
% R
ep
ort
ed
Age
Osteopenia
Gait Disturbances
Severe DevelopmentalDelay
Nocturnal Seizures
Temp Dysregulation
Villas N et al. Epilepsy Behav. 2017;74:81-86. 13
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Patient
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0 20 40 60 80 100
Dental Issues
Frequent Infections & Immunity Issues
Hearing/Vision/Neurological Issues
Cardiac Issues
Psychiatric Issues
Urinary Tract, Bowel, & Digestive Issues
Developmental Slowing, Regression, or Stagnation
Autistic Characteristics
Communication Issues
Developmental Delays
Growth, Endocrine Function, & Metabolism Issues
Sleep Disorders
Orthopedic & Movement Issues
% of Caregivers Responding "Yes" to Any Issue in the Category
Frequency of Issues Reported
Villas N et al. Epilepsy Behav. 2017;74:81-86. 15
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Caregiver Concerns
After seizure control:
1. Speech/Communication (43)
“We don’t know if he’s hurt.”
“…inability to communicate her feelings.” “I don’t know if he’s sick or in pain.”
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Caregiver Concerns
After seizure control:
1. Speech/Communication (43)
2. Sibling Impacts (42)
“Time solely devoted to one child, the other siblings feel left out.”
“Concern for sibling’s quality of life.”
• 74% report having concerns about the emotional impact on siblings
Villas N et al. Epilepsy Behav. 2017;74:81-86. 17
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Caregiver Concerns After seizure control:
1. Speech/Communication (43)
2. Sibling Impacts (42)
3. Cognitive/Developmental Delay (39)
72% reported moderate developmental delay 57% reported severe developmental delay
80% reported global memory/executive function issues
Villas N et al. Epilepsy Behav. 2017;74:81-86. 18
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Caregiver Concerns
After seizure control:
1. Speech/Communication (43)
2. Sibling Impacts (42)
3. Cognitive/Developmental Delay (39)
4. Behavior (34)
Behavior/Psychiatric Issues Reported as “Sometimes” or “Often”
0 50 100
% Reported
“BEHAVIOR”
Difficulty with impulse control
ADD or ADHD
Irritability
Aggression
Anxiety
Perseveration
Villas N et al. Epilepsy Behav. 2017;74:81-86. 19
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Caregiver Concerns After seizure control:
1. Speech/Communication (43)
2. Sibling Impacts
3. Cognitive/Developmental Delay
4. Behavior
5. Long-Term Care
“Where will he live when his mom and I are gone?”
“How will I manage to look after my son when I am older? (I am already 50 and exhausted)..”
Villas N et al. Epilepsy Behav. 2017;74:81-86. 20
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Caregiver Concerns
After seizure control:
1. Speech/Communication (43)
2. Sibling Impacts
3. Cognitive/Developmental Delay
4. Behavior
5. Long-Term Care
6. SUDEP and Mortality
59% 24%
12%
6%
n=17 SUDEP
StatusEpilepticus
Drowning
Asphyxia
SUDEP=sudden unexpected death in epilepsy.
Villas N et al. Epilepsy Behav. 2017;74:81-86; Cooper M et al. Epilepsy Res. 2016;128:43-47.
Classification of Mortality
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Impact on the Caregiver 97% reported sleep issues
82% sleep with the patient
46% use a pulse oximeter
66% of caregivers reported depression
“First marriage broke down due to pressures of caring, we are now divorced”
Villas N et al. Epilepsy Behav. 2017;74:81-86. 22
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Impact on the Family
Logistical
0-3 years: Frequent status Outings difficult, cut short
11+ years: Can’t move patient after simple seizure, behavioral refusals Outings difficult, take longer than anticipated
Physical
Nocturnal seizures, fear of SUDEP, sleep issues Exhaustion
Transfers, equipment (wheelchairs, O2, emergency bag) Exhaustion
Constant care Exhaustion
Villas N et al. Epilepsy Behav. 2017;74:81-86. 23
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Conclusion
Dravet syndrome is more than seizures, and significantly decreases the patient’s quality of life
Dravet syndrome impacts the patient and the family
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Assessing the Impact of Caring for a
Child With Dravet Syndrome:
Results of a Single Center Survey
Kelly G. Knupp, MD, MSCS, FAES
Associate Professor of Pediatrics and Neurology
Neurology and Neurodiagnostics
Children’s Hospital Colorado,
University of Colorado Denver
Denver, Colorado
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Themes I Hear in Clinic
• Constipation provokes seizures
• Poor sleep
• Long mealtimes
• Ambulation concerns
• No response to pain Leads to injuries
• Autonomic symptoms Flushing, not tolerating heat/cold
Racing HR
• Behavior Perseveration
Safety
Dravet syndrome
affects many body
systems; therefore,
family impact is large
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Family Impact
• High stress in caregivers Deterioration of relationships
Fear
Uncertainty
Sleep problems
• Sleep deprivation
• Reduced mental health
• Deterioration of relationships
• Financial burden
• Depression
Nolan KJ et al. Dev Med Child Neurol. 2006;48(9):761-765; Skluzacek JV et al. Epilepsia. 2011;52 suppl 2:95-101;
Jensen MP et al. Epilepsy Behav. 2017;74:135-143. 27
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Methods
• Survey emailed to caregivers of children with Dravet syndrome
at single institution
• Electronic survey administered through REDcap
• Assessed the following domains: Time spent
Difficulty performing caregiver tasks
Caregiver health-related quality of life (QoL)
Caregiver work-related productivity/activity impairment
28 Whittington MD et al. Epilepsy Behav. 2018;80:109-113.
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Response Rate
• Sent to 60 caregivers 34 (57%) response rate
Of these, 30 (88%) had complete response
Patients aged 2 to 22 years
91% had known SCN1A mutation
73% of caregivers were employed
29 Whittington MD et al. Epilepsy Behav. 2018;80:109-113.
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Moderate or Greater Time Burden
• Providing transportation (93%)
• Personal [DS patient] care (87%)
• Additional household tasks (83%)
• Communication (80%)
• Symptom observation (77%)
30 Campbell JD et al. Epilepsy Behav. 2018;80:152-156.
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Moderate or Greater Difficulty
• Arranging for care (73%)
• Communication (70%)
• Coordinating resources (67%)
• Managing behavior problems (67%)
• Personal care (63%)
31 Campbell JD et al. Epilepsy Behav. 2018;80:152-156.
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Time and Difficulty of Tasks
32
Reprinted from Epilepsy & Behavior, 80, Campbell JD, Whittington MD, Kim CH, VanderVeen GR, Knupp KG, Gammaitoni A. Assessing the impact of
caring for a child with Dravet syndrome: Results of a caregiver survey, 152-156, Copyright 2018, with permission from Elsevier.
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Impact on Work Productivity and
Leisure Time EQ-5D VAS ≥65 (n=18) EQ-5D VAS <65 (n=12)
Mean (SD) Median (IQR) Mean (SD) Median (IQR)
Weekly time missed from work (hours) 7.4 (15.2) 0.5 (0.0, 2.8) 6.9 (12.3) 0 (0.0, 8.0)
Weekly time missed from leisure (hours) 31.0 (53.9) 7.0 (1.8, 23.0) 57.8 (59.2) 40.0 (7.3, 84.0)
Effect caregiving had on work
productivity 39.1 (25.6) 52.0 (13.8, 58.0) 76.9 (19.8) 75.0 (68.0, 90.0)
Effect caregiving had on leisure time 55.1 (24.0) 55.5 (39.5, 69.3) 82.6 (12.4) 81 (77.3, 91.8)
EQ-5D=EuroQol health-related quality-of-life survey; IQR=interquartile range; VAS=visual analog scale.
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Reprinted from Epilepsy & Behavior, 80, Campbell JD, Whittington MD, Kim CH, VanderVeen GR, Knupp KG, Gammaitoni A. Assessing the impact of
caring for a child with Dravet syndrome: Results of a caregiver survey, 152-156, Copyright 2018, with permission from Elsevier.
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Cost of Care Schematic
34
Reprinted from Epilepsy & Behavior, 80, Whittington MD, Knupp KG, VanderVeen G, Kim C, Gammaitoni A, Campbell JD. The direct and indirect
costs of Dravet Syndrome, 109-113, Copyright 2018, with permission from Elsevier.
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Per-Person Direct Cost of Care
Cost Component Mean Unit
Cost
Caregiver-Reported
Annualized Rate
Mean (SD)
Annual Cost
Mean (SD)
Conventional Health Care Utilization
In-Home Visits $214 46.23 (137.64) $9,894 ($29,456)
Doctor Visits $245 11.13 (9.07) $2,728 ($2,221)
Emergency Department Visits $788 1.90 (2.27) $1,497 ($1,789)
Hospitalizations $10,204 1.13 (2.16) $11,565 ($22,001)
Ground Ambulance $1,111 0.67 (1.58) $741 ($1,753)
Air Ambulance $7,160 0.07 (0.25) $477 ($1,786)
Complementary and Alternative Health Care Utilization
Chiropractic Services $36 6.53 (16.80) $235 ($605)
Multivitamin Use $10 6.33 (9.07) $63 ($91)
Essential Oil Use $10 2.57 (5.90) $26 ($59)
Marijuana Prescription $150 0.33 (0.83) $50 ($125)
Total Annual Direct Cost
Mean (95% interval)
$27,276
($15,757, $41,904)
35
Reprinted from Epilepsy & Behavior, 80, Whittington MD, Knupp KG, VanderVeen G, Kim C, Gammaitoni A, Campbell JD. The direct and indirect
costs of Dravet Syndrome, 109-113, Copyright 2018, with permission from Elsevier.
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Indirect Cost Burden
Caregiver-Reported Time
Mean (SD)
Annual Cost
Mean (SD)
Lost Productivity (n=24, 73%)
Absenteeism 381 (704) hours $7,587 ($16,941)
Presenteeism 616 (719) hours $12,338 ($19,196)
Lost Leisure Time (n=33, 100%) 2,047 (2,929) hours $52,415 ($74,932)
Income Loss Due to Caregiving (n=21, 64%) $9,242 ($19,410)
Total Annual Indirect Cost
Mean (95% interval)
$81,582
($57,253, $110,151)
Total time commitment = 380 eight-hour work days/year
36
Reprinted from Epilepsy & Behavior, 80, Whittington MD, Knupp KG, VanderVeen G, Kim C, Gammaitoni A, Campbell JD. The direct and indirect
costs of Dravet Syndrome, 109-113, Copyright 2018, with permission from Elsevier.
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Conclusion
• Caregivers spend significant amount of time providing care
for children with Dravet syndrome
• Direct and indirect cost of care is great
• Total time commitment = 380 eight-hour work days per year!
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SUDEP in Dravet Syndrome: What Do We Know
About Pathophysiology? Lieven G. Lagae, MD, PhD
Professor of Paediatric Neurology
Director of Paediatric Neurology
University Hospitals Leuven – Paediatric Neurology
Leuven, Flanders, Belgium
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Presentation Outline
• SUDEP and epidemiology
• Pathophysiology and risk factors
• Mortality and SUDEP in Dravet syndrome
• Preventive measures?
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Definition and Incidence of SUDEP
SUDEP is defined as sudden, unexpected, nontraumatic, nondrowning death in an individual with epilepsy, witnessed or unwitnessed, in which postmortem examination does not reveal an anatomical or toxicological cause of death. Documented status epilepticus is excluded.
Adapted from Shankar R et al. Epileptic Disord. 2017;19(1):1-9; Harden C et al. Neurology. 2017;88(17):1674-1680. 40
Practice Guidelines Summary* Incidence of SUDEP in Different Epilepsy Populations
*Complete guideline information available at Neurology.org † 95% CI (confidence interval)
0.22
1.2
0.58
0.0
0.2
0.4
0.6
0.8
1.0
1.2
1.4
Childhood Adulthood Overall
In…
MODERATE Confidence
LOW Confidence
LOW Confidence
(0.64-2.32) †
(0.16-0.31)†
(0.31-1.08)†
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Sudden Unexpected Death in Epilepsy
41 Reprinted from The Lancet, 378/9808, Shorvon S, Tomson T. Sudden unexpected death in epilepsy, 2028-2038, Copyright 2011, with permission
from Elsevier.
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Reprinted from The Lancet Neurology, 7/11, Tomson T, Nashef L, Ryvlin P. Sudden unexpected death in epilepsy: current knowledge and future directions,
1021-1031, Copyright 2008, with permission from Elsevier.
Sudden Unexpected Death in Epilepsy: Current Knowledge and Future Directions
42
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Typical Cardiovascular Events Peri-ictal
43 Reprinted by permission from Springer Customer Service Centre GmbH: Springer Nature. Nature Reviews Neurology. Mechanisms of sudden unexpected
death in epilepsy: the pathway to prevention. Massey CA, Sower LP, Dlouhy BJ, Richerson GB. 10(5);271-282. 2014.
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Seizures Leading to SUDEP : The MORTEMUS Study
44
(Secondary) GTC Variable duration Generalized EEG suppression Night – Prone Early collapse 3 min, sometimes already fatal First respiratory suppression, then asystole
Reprinted from The Lancet Neurology, 12/10, Ryvlin P, Nashef L, Lhatoo SD, et al. Incidence and mechanisms of cardiorespiratory arrests in epilepsy
monitoring units (MORTEMUS): a retrospective study, 966-977, Copyright 2013, with permission from Elsevier.
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At end of fatal seizure = breathing >18 min At end of fatal seizure = heart rhythm very variable
Seizures Leading to SUDEP : The MORTEMUS Study
45 Reprinted from The Lancet Neurology, 12/10, Ryvlin P, Nashef L, Lhatoo SD, et al. Incidence and mechanisms of cardiorespiratory arrests in epilepsy
monitoring units (MORTEMUS): a retrospective study, 966-977, Copyright 2013, with permission from Elsevier.
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Role of Brainstem Serotonin?
46 Reprinted by permission from Springer Customer Service Centre GmbH: Springer Nature. Nature Reviews Neurology. Mechanisms of sudden unexpected
death in epilepsy: the pathway to prevention. Massey CA, Sower LP, Dlouhy BJ, Richerson GB. 10(5);271-282. 2014.
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4-aminopyridine in cortex
ECG=electrocardiogram; SD=spreading depolarization.
Spreading Depolarization in the Brainstem Mediates Sudden Cardiorespiratory Arrest in Mouse SUDEP Models
47 From Aiba I, Noebels JL. Spreading depolarization in the brainstem mediates sudden cardiorespiratory arrest in mouse SUDEP models. Sci Transl Med.
2015;7(282):282ra46. Reprinted with permission from American Association for the Advancement of Science.
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Genetic Risk Factors
48 Reprinted by permission from Springer Customer Service Centre GmbH: Springer Nature. Nature Reviews Neurology. Mechanisms of sudden unexpected
death in epilepsy: the pathway to prevention. Massey CA, Sower LP, Dlouhy BJ, Richerson GB. 10(5);271-282. 2014.
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Klassen TL et al. Epilepsia. 2014;55(2):e6-e12. Reprinted with permission.
CNV=copy number variant.
High-Resolution Molecular Genomic Autopsy Reveals Complex Sudden Unexpected Death in Epilepsy Risk Profile
3-year-old boy with Dravet syndrome and SUDEP
De novo single nucleotide polymorphisms and CNVs in: SCN1A, KCNA1 and RYR3 and HTR2C
49
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Adapted from Harden C et al. Neurology. 2017;88(17):1674-1680.
Practice guideline summary. Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society
Risk Factors for SUDEP
50
10
5.07
15.46
4.7 6
0.4 0.1
0.02.04.06.08.0
10.012.014.016.0
Presence ofGTCS vs lack of
GTCS
Frequency ofGTCS
(1-2 GTCS/yr)
Frequency ofGTCS
(>3 GTSC/yr)
Not beingseizure-free
for 1-5 yr
Not adding anAED when
patients aremedicallyrefractory
Nocturnalsupervision
(riskreduction)
Use ofnocturnallistening
device (riskreduction)
Od
ds
Rat
io
(0.2-0.8)* (0-0.3)*
MODERATE Confidence
(7-14)*
(2.94-8.76)* (1.4-16)* (2-20)*
*CI
AED=antiepileptic drug; GTCS=generalized tonic-clonic seizure.
MODERATE Confidence
MODERATE Confidence
MODERATE Confidence
MODERATE Confidence
(9.92-24.10)*
HIGH Confidence
HIGH Confidence
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Ranking the Leading Risk Factors in SUDEP
51
DeGiorgio CM, Markovic D, Mazumder R, Moseley BD. Ranking the leading risk factors for sudden unexpected death in epilepsy. Frontiers in Neurology.
2017;8:Article 473. https://www.frontiersin.org/articles/10.3389/fneur.2017.00473/full. This is an open-access article distributed under the terms of the
Creative Commons Attribution License (CC BY) and is available under Public License, https://creativecommons.org/licenses/by/4.0/legalcode.
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Premature Mortality in Dravet Syndrome
Mean Age 8.7 ± 9.8 yrs 73% < 10 yrs age 93% < 20 yrs age
DS=Dravet syndrome; SE=status epilepticus.
52 Reprinted from Epilepsy & Behavior, 64/Pt A, Shmuely S, Sisodiya SM, Gunning WB, Sander JW, Thijs RD. Mortality in Dravet syndrome: A review, 69-74,
Copyright 2016, with permission from Elsevier.
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Epilepsy-related deaths SUDEP 49% (n=87) + Status Epilepticus 32% (n=56) = 81% of all premature deaths compared with <3% new-onset epilepsies (non-DS)
Cause of Death in 177 Dravet Syndrome Cases
53 Reprinted from Epilepsy & Behavior, 64/Pt A, Shmuely S, Sisodiya SM, Gunning WB, Sander JW, Thijs RD. Mortality in Dravet syndrome: A review, 69-74,
Copyright 2016, with permission from Elsevier.
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100 DS patients followed for a median of 17 years : 17 dead, 10/17 : SUDEP Dravet-specific SUDEP rate : 9.32/1000 person-years
Mortality in Dravet Syndrome
54 Reprinted from Epilepsy Research, 128, Cooper MS, Mcintosh A, Crompton DE, et al. Mortality in Dravet syndrome, 43-47, 2016,
with permission from Elsevier.
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Dravet ?
Ranking the Leading Risk Factors in SUDEP
55
DeGiorgio CM, Markovic D, Mazumder R, Moseley BD. Ranking the leading risk factors for sudden unexpected death in epilepsy. Frontiers in Neurology.
2017;8:Article 473. https://www.frontiersin.org/articles/10.3389/fneur.2017.00473/full. This is an open-access article distributed under the terms of the
Creative Commons Attribution License (CC BY) and is available under Public License, https://creativecommons.org/licenses/by/4.0/legalcode.
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Cardiac Abnormalities in Dravet Syndrome
DS patients had depressed Heart Rate Variability (HRV) variables compared with patients with epilepsy (ES) patients (ES/AED and ES/no-AED) and healthy control group.
ES=epileptic syndrome; RR=inter-beat; SDNN=standard deviation of normal-to-normal.
56 Reprinted with permission. Delogu AB, Spinelli A, Battaglia D, et al. Electrical and autonomic cardiac function in patients with Dravet syndrome. Epilepsia.
John Wiley and Sons. Wiley Periodicals, Inc. © 2011 International League Against Epilepsy.
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Adapted from Auerbach DS et al. PLoS One. 2013;8(10):e77843.
EADs=early afterdepolarizations.
Altered Cardiac Electrophysiology and SUDEP in a Model of Dravet Syndrome
57
Increase Na influx Increased excitability
Heart rate decrease before SUDEP
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Sudden Unexpected Death in Epilepsy: Basic Mechanisms and Clinical Implications for Prevention
58 Reproduced from Journal of Neurology, Neurosurgery & Psychiatry, Dlouhy BJ, Gehlbach BK, Richerson GB. vol. 87, 402-413, 2016,
with permission from BMJ Publishing Group Ltd.
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59 Epilepsy Foundation of America. https://www.epilepsy.com/make-difference/public-awareness/aimforzero-striving-toward-future-free-sudden-
unexpected-death. Accessed February 12, 2018.
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Non-EEG Seizure Detection Systems and Potential SUDEP Prevention: State of the Art: Review and Update
Monitoring Patients at Night?
Reprinted from Seizure, vol. 41, Van de Vel A, Cuppens K, Bonroy B, et al. Non-EEG seizure detection systems and potential SUDEP prevention:
State of the art: Review and update, 141-153, Copyright 2016, with permission from Elsevier. 60
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61
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We found very low-quality evidence of a preventative effect for nocturnal supervision against SUDEP. Further research is required to identify the effectiveness of other current interventions, for example, seizure detection devices, safety pillows, SSRIs, early surgical evaluation, educational program, and opiate and adenosine antagonists in preventing SUDEP in people with epilepsy.
Maguire MJ et al. Cochrane Database Syst Rev. 2016;7:CD011792.
Treatments for the Prevention of Sudden Unexpected Death in Epilepsy (SUDEP)
62
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Summary: SUDEP in Dravet Syndrome
• Pathophysiology and risk factors:
refractory syndrome factors and (compound) genetic factors
• Mortality and SUDEP in Dravet syndrome
> 10 x higher than in other epilepsies
• Need for SUDEP preventive studies
63
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Approaches to Treatment of Dravet Syndrome:
What's on the Horizon?
Joseph E. Sullivan, MD Associate Professor of Neurology & Pediatrics University of California, San Francisco (UCSF)
Director, UCSF Pediatric Epilepsy Center of Excellence San Francisco, California
64
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Presentation Outline
• Dravet treatment landscape pre-2012
• Cannabidiol (CBD) Phase 3 Review
• Fenfluramine Phase 3 Review
• On the horizon
65
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Treatments
• Valproate
• Topiramate
• Clobazam
• Stiripentol
• Levetiracetam
• Ketogenic diet
• Vagal nerve stimulation
• Bromides
• Verapamil
• Rescue plans with benzodiazepines
• Avoidance of carbamazepine, oxcarbazepine, phenytoin, lamotrigine
66
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Sad, But Honest
67
The Pharmacologic Treatment of Dravet Syndrome • Valproate is used as a first-line agent to prevent the recurrence of
febrile seizures, and oral/nasal/rectal benzodiazepine is used for any long-lasting seizures, but these agents are most often insufficient
Chiron C, Dulac O. Epilepsia. 2011;52 suppl 2:72-75
Current therapeutic procedures in Dravet syndrome • Valproate and benzodiazepines are the first-line treatments, but are
usually insufficient therapeutic options Chiron C. Dev Med Child Neurol. 2011;53 suppl 2:16-18
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The Data (or Lack Thereof!)
• Recent Cochrane Review 2013
• 14 studies – 11 excluded (9 uncontrolled, 2 abstract only, 1 metanalysis)
– Left with 2 studies, both of which evaluated stiripentol (STP)
Brigo F, Storti M. Cochrane Database Syst Rev. 2013;(11):CD010483. 68
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Syndrome-specific Treatment? Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-
controlled syndrome-dedicated trial
69 Chiron C et al. Lancet. 2000;356(9242):1638-1642.
Methods
• After a baseline period of 1 month, placebo (n=20) or stiripentol (n=21)
Findings
• 15 (71%) patients were responders on stiripentol (including 9 free of clonic or tonic-clonic seizures),
• (-69%) than on placebo (+7%), P<·0001
Interpretation
• Results also provide good reason to focus studies on a specific epilepsy syndrome–a small sample of patients
is sufficient to show the efficacy that might have been missed in a heterogeneous population
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70 Young S. Marijuana stops child’s severe seizures. CNN Health Web site. http://www.cnn.com/2013/08/07/health/charlotte-child-medical-
marijuana/index.html. Updated August 7, 2013. Accessed January 10, 2018.
Marijuana Stops Child’s Severe Seizures
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Devinsky O et al; Cannabidiol in Dravet Syndrome Study Group. N Engl J Med. 2017;376(21):2011-2020.
Trial of Cannabidiol For Drug-resistant Seizures in the Dravet Syndrome
71
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Study Overview
• Phase 3 double-blind, placebo-controlled trial
• 120 subjects randomized – 61 CBD (20mg/kg/d) vs 59 placebo
– Baseline seizure frequency (14 per month)
• 2-week dose escalation followed by 12-week maintenance
• 12 withdrew (9 CBD vs 3 placebo)
• Median of 3 concomitant AEDs (clobazam, valproates, levetiracetam, topiramate)
Devinsky O et al; Cannabidiol in Dravet Syndrome Study Group. N Engl J Med. 2017;376(21):2011-2020. 72
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CBD 5% seizure free vs 0 in placebo
73
Cannabinoids for Epilepsy – Real Data, At Last
From The New England Journal of Medicine, Devinsky O, Cross JH, Laux L, et al; Cannabidiol in Dravet Syndrome Study Group, Trial of cannabidiol for
drug-resistant seizures in the Dravet syndrome, vol. 376, 2011-2020. Copyright © 2017 Massachusetts Medical Society. Reprinted with permission from
Massachusetts Medical Society; Berkovic SF. N Engl J Med. 2017;376(21):2075-2076.
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Cross JH et al. Poster presented at: American Epilepsy Society Annual Meeting; December 2-6, 2016; Houston, TX.
Second Phase 3 Randomized Control Trial
• 12-week maintenance period
• Treatment effect increased for patients receiving cannabidiol
74
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Adverse Events
Devinsky O et al; Cannabidiol in Dravet Syndrome Study Group. N Engl J Med. 2017;376(21):2011-2020.
93% Treatment vs 75% Placebo
• Diarrhea • Decreased appetite
• Vomiting • Lethargy
• Fatigue • Somnolence
• Pyrexia • Fatigue
• URI
75
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CBD Conclusions
• Anecdotal experience led to well-designed placebo-controlled trials
• Appears to be safe, well tolerated, and effective in reducing seizures in Dravet syndrome
• Mechanism of action of cannabidiol remains poorly understood
• Role of other cannabinoids needs further study
76
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Fenfluramine in Dravet Syndrome
Ceulemans B et al. Epilepsia. 2012;53(7):1131-1139. 77
Successful Use of Fenfluramine as an Add-on Treatment For Dravet Syndrome
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78 Reprinted with permission. Ceulemans B, Boel M, Leyssens K, et al. Successful use of fenfluramine as an add‐on treatment for Dravet syndrome. Epilepsia.
John Wiley and Sons. Wiley Periodicals, Inc. © 2012 International League Against Epilepsy.
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Fenfluramine Study
• Phase 3 double-blind, placebo-controlled trial
• 119 subjects randomized – 39 (0.8 mg/kg/d), 40 (0.2 mg/kg/d), 40 (placebo) – Baseline seizure frequency (40 per month)
• 6-week baseline, 2-week titration, 12-week maintenance
• 5 subjects withdrew (all in 0.8 mg/kg/d)
• Most on 2 to 3 concomitant AEDs (clobazam, valproates, topiramate, levetiracetam)
Lagae L et al. ZX008 (fenfluramine) in Dravet syndrome: results of a phase 3, randomized, double-blind, placebo-controlled trial. Poster presented at:
71st American Epilepsy Society Annual Meeting; December 1-5, 2017; Washington, DC. 79
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ZX008 – Initial Phase 3 Clinical Trial Results
80 Lagae L et al. ZX008 (fenfluramine) in Dravet syndrome: results of a phase 3, randomized, double-blind, placebo-controlled trial. Poster presented at:
71st American Epilepsy Society Annual Meeting; December 1-5, 2017; Washington, DC.
• Phase 3 randomized, double-blind, placebo-controlled clinical trial of children and young adults with Dravet syndrome
• The study met its primary objective of demonstrating that ZX008 at 0.8 mg/kg/d was superior to placebo as adjunctive treatment according to the change in the frequency of convulsive seizures between the 6-week baseline period and the 14-week treatment period
– Patients treated with ZX008 0.8 mg/kg/d achieved a mean 63.9% reduction in monthly seizures compared with placebo (P<.001)
• Patients treated with ZX008 0.2 mg/kg/d also demonstrated statistically significant reductions in monthly convulsive seizures compared with placebo, with the results suggesting a dose-response relationship
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ZX008 – Initial Phase 3 Clinical Trial Results (cont’d)
• 70% of patients treated with ZX008 0.8 mg/kg/d achieved a ≥50% reduction in monthly convulsive seizures compared with 7.5% of placebo-treated patients (P<.001)
• 45% of patients treated with ZX008 0.8 mg/kg/d achieved a ≥75% reduction in monthly convulsive seizures compared with 2.5% of placebo-treated patients (P=.001)
• ZX008 was generally well tolerated, with adverse events consistent with the known safety profile of fenfluramine
• 95% of patients treated with either dose of ZX008 experienced at least 1 treatment-emergent adverse event compared with 65% of placebo-treated patients
• Prospective safety monitoring throughout the study found no clinical or echocardiographic evidence of cardiac valvulopathy or pulmonary hypertension
81 Lagae L et al. ZX008 (fenfluramine) in Dravet syndrome: results of a phase 3, randomized, double-blind, placebo-controlled trial. Poster presented at:
71st American Epilepsy Society Annual Meeting; December 1-5, 2017; Washington, DC.
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Adverse Events
95% Treatment vs 65% Placebo
• Diarrhea • URI
• Vomiting • Decreased Appetite
• Pyrexia • Lethargy
• Nasopharyngitis • Somnolence
82 Lagae L et al. ZX008 (fenfluramine) in Dravet syndrome: results of a phase 3, randomized, double-blind, placebo-controlled trial. Poster presented at:
71st American Epilepsy Society Annual Meeting; December 1-5, 2017; Washington, DC.
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Cardiac Echo Findings
5 Placebo, 7 (0.2 mg/kg), 9 (0.8 mg/kg)
• No clinically significant abnormalities
• Trace mitral regurgitation or aortic regurgitation
83 Lagae L et al. ZX008 (fenfluramine) in Dravet syndrome: results of a phase 3, randomized, double-blind, placebo-controlled trial. Poster presented at:
71st American Epilepsy Society Annual Meeting; December 1-5, 2017; Washington, DC.
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Fenfluramine Conclusions
• Dramatic reduction in seizure frequency – Higher dose is superior to lower dose
• Clinically significant number of patients with “Near Seizure Freedom”
• Safe and well tolerated
• No clinically relevant cardiac echo findings
84
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On the Horizon
85
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Blinded Drug Screen
• Clinical observations led to studies
• 3500 FDA-approved compounds
• Screened in this SCN1 zebrafish model at 100 and 667 µM
• Observed for swim behavior – Electrophysiologic forebrain recordings
Courtesy of Baraban Lab 86
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87 Reprinted by permission from Springer Customer Service Centre GmbH: Springer Nature. Nature Communications. Drug screening in Scn1a zebrafish mutant
identifies clemizole as a potential Dravet syndrome treatment, Baraban SC, Dinday MT, Hortopan GA. 2013.
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Clemizole
• FDA approved with safe toxicology profile
• H1 antagonist
• NS4B RNA inhibiting properties
• What is the mechanism of action?
88
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Mechanisms of Action • Clemizole hypothesized to act
independently of H1 antagonism
• 49 drugs with antihistaminergic properties – None inhibited mutant seizure
behavior – 3 were toxic
89
Dinday M, Baraban SC. Large-scale phenotype-based antiepileptic drug screening in a zebrafish model of Dravet syndrome. eNeuro. 2015;2(4):e0068-15.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596025/. This is an open-access article distributed under the terms of the Creative Commons Attribution
License (CC BY) and is available under Public License, https://creativecommons.org/licenses/by/4.0/legalcode.
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• Huperzine A (Biscayne Pharmaceuticals)
• Fenfluramine (Zogenix)
90
Dinday M, Baraban SC. Large-scale phenotype-based antiepileptic drug screening in a zebrafish model of Dravet syndrome. eNeuro. 2015;2(4):e0068-15.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596025/. This is an open-access article distributed under the terms of the Creative Commons Attribution
License (CC BY) and is available under Public License, https://creativecommons.org/licenses/by/4.0/legalcode.
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Adapted from Griffin A et al. Brain. 2017;140(3):669-683. 91
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Disease Modifying?
• OPK-88001
• Phase 2 study-PK, safety and tolerability
– AntagoNAT (anti-Natural Antisense Transcript compound)
• Preliminary animal data increased SCN1A expression in mice
• Lumbar puncture on days 1, 14, 28, 56, 84
• Secondary end points – Seizure frequency
Hsiao J et al. EBioMedicine. 2016;9:257-277. 92
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Conclusions
• 2 novel and effective drugs for the treatment of Dravet syndrome in just the past 3 years
• Open-label studies with both compounds are ongoing to determine durability of treatment effect
• Well-designed animal models are identifying novel compounds with novel pathways (serotonin)
• Disease-modifying therapies being explored
• Improved treatments at an earlier age may lead to improved outcomes
93
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