The ”sparks” and the ”soup”

”I wonder whether anybody during my few remaining years will yet discover either of the (probably) two missing transmitters concerned in your monosynaptic excitatory and inhibitory effects on different motoneurones”.

Dale to Eccles, October 1, 1953

OH

NH2

COOHOH

NH2

COOH

OH

OH

NH2OH

OH

NH2OH

OH

tyrosine DOPA

dopamine noradrenaline

Biosynthetic pathway for noradrenaline

Hans Corrodi, 1929-1974

A New Concept (1970s):Medicinal chemistry and pharmacology

Under the same roof In academic setting

High

Low

Normal

Psychomotor activation

Dopamine stabilizer

High

Low

Normal

Psychomotor activation

Standard antipsychotic

Dopamine Stabilizers

n-Pr

SO2CH

3

N

H

Structure of (-)-OSU6162

Future Vision:Restart Our Drug Research

According to the Previous ConceptSupported by The Arvid Carlsson Fund