The role of biological monitoring in managing occupational skin exposure to isocyanates · 2020. 3....
Transcript of The role of biological monitoring in managing occupational skin exposure to isocyanates · 2020. 3....
Health and SafetyExecutive
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The role of biologicalmonitoring in managingoccupational skin exposureto isocyanates
16 September 2019
Kate Jones
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What is Biological Monitoring?Assessment of overall systemic exposure to
chemicals by measurement of the chemicals or theirbreakdown products in
blood and breathurine
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Dermal-specific techniques• Interception
– Patches, gloves, suits• Removal
– Hand-washing, tape-stripping• Visualisation
• No simple measure• No agreed standard approach
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Disentangling exposures
Airborneconcentration
BM value
Dermal absorption ?
RPE ?
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Skin Structure
E P ID E R M IS
D E R M IS
S U B C U T A N E O U S
V A S C U L A RS U P P L Y
S tra tu mc o rn e u m
S tra tu m b a s a le
h a ir fo ll ic le
s e b a c e o u s g la n d
s w e a t g la n d
h a ir
p o re
n e rv e e n d in g
P a c in ia nc o rp u s c le
M e is s n e rsc o rp u s c le
F A T
[J e w e ll C .J . a n d W ill ia m s F . M . N e w c a s t le U n iv e rs ity , w it h p e r m is io n ]
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Delayed absorption/excretionUr
inary
excr
etion
Time from start of dose (h)
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Reservoir effectF ifte e n m in u te d e rm a l e x p o s u re
0
5
1 0
1 5
2 0
2 5
0 2 4 6 8 1 0 1 2 1 4
T im e h o u rs
Urinar
y 5-HN
MP D e rm a lE x p o s u re
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Is dermal absorption significant?
Urinary 5-HNMP after inhalation (8h, 10mg/m3) or dermal (1 hand, 15min, 15%) exposure to NMP
10 20 30 40 50 60-5
0
5
10
15
20
25InhalationDermal
Time (hours)
Urina
ry 5-
HNMP
Akrill et al (2002). Toxicol. Lett. 265 - 269
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Isocyanates
• Primarily considered an inhalation hazard, causingrespiratory sensitisation
• However, also cause skin sensitisation and evidenceto show that skin exposure can induce respiratorysensitisation
• Is there evidence to show skin uptake of isocyanates?
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Laying floor screed
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Laying floor screed
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Industrial Flooring Panels
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Intervention – glove type
Glove Type
MDA
inur
ine(µm
ol/mo
lcrea
tinine
)
Leather
Polyester0
2
4
6
8
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Longitudinal monitoring
07/09/2015
03/11/2015
17/05/2016
06/06/2016
19/09/2016
06/02/20170
2
4
6
8MD
Ain
urine
(µm
ol/m
olcr
eatin
ine)
BMGV
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Individual worker exposure patterns
07/09/2015
03/11/2015
17/05/2016
06/06/2016
19/09/2016
06/02/20170
2
4
6
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BM for skin exposure to isocyanates
• Evidence that for MDI (low volatility, low aerosol processes)skin uptake can occur
• Can result in significant body burden compared to UK BMGV
• Tasks may need to be redesigned for best intervention asPPE requires ongoing management
• Even when problem ‘solved’, monitoring is required toreinforce behaviours.