The Research and Development Ecosystem

R.V. Duncan, Ph.D.Vice Chancellor for Research

Rotary Presentation October 12, 2011

Restore the Frontier!

According to the NY Times on 9/29/10:The Midwest will has declined to 94 Congressional seats following the 2010 U.S. Census, down from an all-time high of 143.

Major Midwest Universities like MU can help reverse thistrend

MU = 1/3 Health + 2/3 University

Last year, University of Missouri Health Care admitted 20,260 patients, performed 19,222 surgeries, recorded 510,897 clinic visits and 42,995 emergency-center visits.MU is one of only six public universities in the country with medicine, veterinary medicine, public health, law, engineering and agriculture all on one campus.

MU makes major investments in inter-disciplinary research centers, such as the BLSC, MURR, Dalton, RBL, I2NM2, and others. $55M/year out of $240M+MU’s total budget is just under $2B

Unprecedented Research Growth MU attracts over 70 percent of the federal research dollars flowing to Missouri's public universities. In 2010 MU spent over $44M of NSF funding, the most in Missouri, out of $119M total in State.

In 2010 Thompson Reuters ranked MU 8th in the USA and 15th in the world for plant and animal sciences research impact.

Total External Academic Contract and Grant Awards in 2010 totaled $485M, up $210M over 2006 level.

2011 Fall Enrollment• Record enrollment of

33,800+

• Students represent every Missouri county, every state and 100+ countries

• Very strong student body growth, averaging over 3% per year while many other university growth rates are flat or declining. ACT scores are highest in a decade!

• All out-of-state growth with improvement in student body diversity

What Are We Adapting to?

A VERY rapidly increasing student body!

Mizzou Advantage has catalyzed new teams, and conveyed MU’s strengths concisely to the public.

Emergence of on-line education, with national emphasis on workforce preparation over R&D

Rapid expansion of industrial interest in MU’s R&D capabilities.

Rapidly growing student interest in free-market pursuits, and rapidly declining State support…

Change in Core Funding Sources

0%

20%

40%

60%

80%

100%

1990 1995 2000 2005 2010

70%

27%

3%

39%

54%

7%

Core budget for on-campus teaching and support services

2001-10

State Support Falls Short of Inflation

$245M

$319M

$193M

$189M

0255075

100125150175200225250275300325350

2001 2002 2003 2004 2005 2006 2007 2008 2009 2010

millions

2010 shortfall: $130MShortfall since 2001: $728M

Inflation Adjusted

Inflation & Enrollment Adjusted

Actual Received

Technology Commercialization • Rapid growth in Intellectual Property Licensing Revenues,

Disclosures, and Licensing Deals. Licensing revenues total almost $60M from over $1B in gross sales by companies that licensed MU technology

• Licensing revenues grew from $4.7M in FY07 to $10.1M in FY09, representing a 600% ROI in 2009. A small decline since then in gross revenues, as net revenues increased.

• Missouri Life Sciences Business Incubator at MU

• Dedicated in May, 2009

• Jake Halliday, Executive Director

• Coulter Opportunity!

Technology Transfer ChallengesThe Interface at which we operate

UNIVERSITY INDUSTRY

Commercializationof New and Useful

Technologies

Teaching

Research

Service

EconomicDevelopment

Profits

Product R&D

Knowledge for Knowledge’s Sake

Academic FreedomOpen Discourse

Management ofKnowledge for Profit

ConfidentialityLimited Public Disclosure

Technology Commercialization, Con’t. • Savage River Farms venture capitalized by Kleiner Perkins,

and delivering product as of 9/2/11. MU has licensed the IP, taken equity in the company, and secured a commitment for a Missouri plant within five years.

• Shasun NBI, LLC attracts millions of dollars from Chennai, India to create high-end drug development jobs in Missouri

• Organovo was named as one of the top 50 inventions of 2010 by Time Magazine, and is now going public.

• Proposed system for making 150M gallons / year of butanol from woody biomass along major river valleys in the USA

• At last years R&D Advisory Board Meeting, VC Martin Sanders teamed with MU Professor John Viator to create a company that detects blood-borne pathogens photo-acoustically.

Organovo and Organ Printing

Invented by Professor Gabor Forgacs at MU

See: http://www.organovo.com/

C.E.O.: Keith Murphy

The Economist Magazine

Pharmaceutical Research

MURR CenterMURR Center

College of Veterinary Medicine

School of Medicine

Chemistry and Biochemistry

Physics and Radiology

MURR Pharmaceutical Research

25-year history of successful and innovative pharmaceutical research, including the development of:

• CeretecTM (with 99mTc), a diagnostic used to evaluate cerebral blood flow in patients.

• Quadramet® (with 153Sm), a therapeutic for treatment of pain associated with metastatic bone cancer.

• TheraSphere® (with 90Y), a glass microsphere used to treat patients with inoperable liver cancer.

• Zegerid ®, an antacid and not a radio-pharmaceutical, is by far our most successful drug ever, with over 40 million dollars in royalties and over a billion dollars in total sales.

Impact: Plant and Animal SciencesInstitution Papers Citations Citations/paper

1 John Innes Centre, UK 1,134 42,568 37.542 RIKEN, Japan 926 25,453 27.49 3 Max Planck Society, Germany 2,858 65,851 23.04 4 University of California, San Diego 1,143 25,349 22.18 5 University of California, Berkeley 2,121 43,417 20.47 6 University of Arizona 1,717 31,073 18.10 7 CNRS, France 2,303 33,022 14.34 8 University of Washington 2,226 31,089 13.97 9 Wageningen University 4,083 54,517 13.35 10 University of Cambridge 1,949 25,875 13.28 11 CSIRO, Australia 3,729 49,339 13.23 12 Cornell University 4,912 64,964 13.23 13 Washington State University 2,473 32,544 13.16 14 University of Wisconsin 3,977 52,336 13.16 15 University of Missouri 2,497 30,756 12.32 16 Purdue University 2,673 32,600 12.20 17 INRA, France 6,199 75,164 12.13 18 Michigan State University 3,469 42,055 12.12 19 University of British Columbia 2,539 29,670 11.69 20 Iowa State University 2,682 31,115 11.60

Thought for the Day

If we all worked on the assumption that what is accepted as true is really true, there would be little hope of advance.

Orville Wright