The reference model for disease progression uses MIST to find data fitness by Jacob Barhak PyData SV...

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The Reference Model for Disease Progression uses MIST to find data fitness Jacob Barhak Austin, Texas http://sites.google.com/site/jacobbarhak/ PyData Silicon Valley 2014 Facebook Headquarters Menlo Park, CA 03 May 2014

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The Reference Model for Disease progression [1,2] is a league of disease models that compete amongst themselves to fit existing clinical trial results. Clinical Trial results are widely available publicly at the summary level. Disease models are typically extracted from a single trial and therefore may not generalize well to all populations. The Reference Model determines the fitness of multiple disease models for multiple populations and helps deduce better fitting scenarios. This is done using High Performance Computing (HPC) techniques that support Monte Carlo simulation at the Micro individual level. The MIcro Simulation Tool (MIST) [3,4] facilitates running those simulations in HPC environment using Sun Grid Engine (SGE) [5]. MIST can even run over the cloud using StarCluster [6] and an anaconda AMI [7]. Note, however, the public published data is summary data while simulations are conducted at the individual level. The individual population is reconstructed from summary data using the MIST Domain Specific Language (DSL) and is optimized using evolutionary computation using Inspyred [8]. This allows creating populations that conform to the clinical trial summary statistics and allow incorporating trial inclusion and exclusion criteria as well as cope with skewed population distributions. The Reference Model allows exploring new assumptions and hypothesis about disease progression and determines their fitness to existing population/model data. These virtual trials consider much more information than a single trial, using already available and public data. Links to relevant own publications: [1] The Reference Model video: http://youtu.be/7qxPSgINaD8 [2] The Reference Model short description: http://healtheconblog.com/2014/03/04/the-reference-model-for-disease-progression/ [3] MIST video presentation: http://www.youtube.com/watch?v=AD896WakR94 [4] MIST github repository: https://github.com/Jacob-Barhak/MIST Links to external free software tools relevant to this work: [5] SGE: http://gridengine.org/blog/ [6] INSPYRED github repository: https://github.com/inspyred/inspyred [7] StarCluster home page: http://star.mit.edu/cluster/ [8] B. Zaitlen, StarCluster Anaconda. Online: http://continuum.io/blog/starcluster-anaconda

Transcript of The reference model for disease progression uses MIST to find data fitness by Jacob Barhak PyData SV...

Page 1: The reference model for disease progression uses MIST to find data fitness by Jacob Barhak PyData SV 2014

The Reference Model for Disease Progression

uses MIST to find data fitness

Jacob BarhakAustin, Texas

http://sites.google.com/site/jacobbarhak/

PyData Silicon Valley 2014Facebook Headquarters

Menlo Park, CA03 May 2014

http://sites.google.com/site/jacobbarhak/
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Disease Modeling - The Very Basics

• Disease models:– Describe phenomena observed in past trials– Attempt to predict future disease progression– Used to predict Costs / Quality of Life

• Typically developed from a certain population

• Current efforts attempt to generalize those models

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The Reference Model

• Built from literature references and hence the name: The Reference Model• Designed to serve as a reference for new equations and populations• A League / Consumers Report for disease models• Current version deals with diabetic populations

MINo CHD Survive MI CHD Death

StrokeNo Stroke Survive Stroke Stroke Death

Alive Other Death

Death

Process CHD

Process Stroke

Process Competing Mortality

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How Does it Work?

• Loop through Risk Equation/Hypothesis combinations• Loop through populations• Calculate fitness of simulation outcomes to observed phenomena

MINo CHD Survive MI CHD Death

StrokeNo Stroke Survive Stroke Stroke Death

Alive Other Death

Death

Process CHD

Process Stroke

Process Competing Mortality

1 2

34

1 2

34

Pop 3

Pop 2

Pop 1

Eq 1 1 1 1 1 …

Eq 2 1 2 3 4 …

Pop 1 4 6 2 1 …

Pop 2 2 4 6 1 …

Pop 3 2 3 9 2 …

… … … … … …

Fitness Matrix

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MIST Basics

• MIST stands for MIcro-Simulation Tool– In a nutshell it is a Monte-Carlo simulation compiler– Offers a Domain Specific Language– Reproducible simulations

• MIST Supports Population Generation– Generating functions– Optimization towards objectives– Evolutionary computation with INSPYRED

• MIST runs over the cloud! – And on Sun Grid Engine (SGE) clusters

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MIST Uses Computing PowerHere is Proof!

Fried after two year of extensive use

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MIST Runs Over the Cloud!

Anaconda drives MIST to run over the Amazon cloud!

• Batch mode MIST utilities allow:– Submitting jobs to Sun Grid Engine (SGE)– Running simulations– Generating reports– Combining reports from multiple repetitions/scenarios

• Star Cluster creates an SGE cluster on the Amazon Elastic Compute Cloud

• The Anaconda Amazon Machine Image (AMI) is used for the cluster master / nodes

• Good for: – Cutting down computation time by renting computing power– Saving initial and maintenance costs associated with a cluster

MIST

Cloud

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Populations: Background• The First Table in a Clinical Trial publication typically contains

Population Statistics– Summary Data Only: Mean (SD) / Median (IQR)– Limited information about distribution– Inclusion/exclusion criteria skew the distribution

–

Example: Excerpt from Table 1 in UKPDS 33

Control InterventionAge 53.3 (8.6) 53.2 (8.6)% Male 61.9% 59.3%Smoke 31% 30%Systolic Blood Pressure (mmHg) 135(20) 135(20)Total Cholesterol (mmol/L) 5.4 (1.02) 5.4(1.12)

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INSPYRED MIST

• INSPYRED MIST can regenerate mock populations from Table 1 in clinical trials

• Only publicly available summary data is used• No need to have access to restricted data

MIST

INSPYREDTable 1

Generate

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MIST uses INSPYRED• Bio Inspired computation Python library

– Evolutionary Computation– Swarm Intelligence– Neural Networks

• Developed and Maintained by Aaron Garrett

• Repository: https://github.com/inspyred/inspyred

https://github.com/inspyred/inspyred
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MISTINSPYRED

INSPYRED Evolutionary Computation: Population Generation & Objectives

• Generation Expressions: – Define how to generate a single individual– Test if individual fits the inclusion/exclusion criteria– Define ties and correlations between characteristics

• Objectives:– Define aggregate targets for the entire population– Reduce random generation error– Handle skewed distributions to fit target

Expression Compiler

Evolutionary Computation

Monte Carlo ResultSelection

Result PopulationConverges toObjectives

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INSPYRED Evolutionary Computation

Generator

Evaluator 3.1 7.5 4.2 5.2

Selector

Crossover MutationVariators

Candidates

Parents

+ = →Repeat

Terminator

Best Solution

Generations / Epocs

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Population Generation ExampleSkewed by Inclusion/Exclusion

• Generate 10 people with:– Inclusion criteria is 45< Age <90– The base population distribution is:

• Age for Male: Mean 53 SD 10• Age for Female: Mean 52 SD 7• Male: 50%

• Generation Functions (Implementation):Age ~ Iif (Male,Gaussian(53,10) ,Gaussian(52,7))Male ~ Bernoulli(0.5)Assert = And(Gr(Age,45),Ls(Age,90))

• Notes:– May not represent well what was intended– Assertion drops non qualifying candidates– The resulting Age is skewed

Age Male48.85785535 059.94741744 056.19039096 164.40825341 049.77582796 160.29975596 151.27571792 172.13820388 155.51746037 058.72574003 0

Final population that would have been reported in Table 1:Age Mean: 57.71366233Age SD: 7.115024093Male Mean: 0.5

Result to be Published

Design is Subject to

Constraints

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Population Generation ExampleWith Objectives & INSPYRED

• Generate 10 people with objectives:– Base distribution & Inclusion criteria as before– Age : Mean 50, SD 5– Male: 60%

• Objectives (Implementation):Age Mean: 50 , Weight 1Age SD: 5 , Weight 1Male: 0.6 , Weight 10

• Notes:– Design matches results as much as possible– The designer can study effect of constraints– Table 1 can now be planned ahead!

Age Male50.8953429 0

53.71135174 152.86278825 0

46.021901 148.36662032 147.87355499 145.11370607 162.15347882 147.48350736 045.93131347 0

Final population selected out of 1000 generated candidates:Age Mean: 50.04135649Age SD: 5.166548964Male Mean: 0.6

Design = Desired +

Constraints

Result to be Published

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The Reference Model Fitness Matrix

Method_A1c 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1Method_BMI 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1Method_BP 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1Method_Lipids 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1Method_Smoke 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1Method_MI 1 1 1 1 1 1 1 1 2 2 2 2 2 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 5 5 5 5 5 6 6 6 6 6 6 6 7 7 7 7 7 8 8 8 8 8 1 1 1 1 1 1 1 1 2 2 2 2 2 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 5 5 5 5 5 6 6 6 6 6 6 6 7 7 7 7 7 8 8 8 8 8Method_Stroke 1 2 3 4 5 6 7 8 1 2 3 4 6 1 2 3 4 5 7 8 1 2 3 4 5 6 7 8 1 3 4 5 6 1 2 4 5 6 7 8 1 3 4 6 7 1 3 4 6 8 1 2 3 4 5 6 7 8 1 2 3 4 6 1 2 3 4 5 7 8 1 2 3 4 5 6 7 8 1 3 4 5 6 1 2 4 5 6 7 8 1 3 4 6 7 1 3 4 6 8Method_DeathCHD 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1Method_DeathStroke 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1Method_TimeImprove -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1FITNESS: LOW SCORE = GOOD FITNESSUKPDS33 Conventional 13.845 20.743 15.914 21.72 25.441 25.36 28.089 18.589 14.877 20.577 14.15 22.322 26.799 29.021 32.342 18.513 28.939 28.647 34.265 42.527 19.646 24.438 25.212 32.941 29.175 23.545 23.493 37.46 30.928 35.489 26.746 31.944 44.571 37.471 44.368 38.836 39.246 37.899 48.124 42.4 8.7074 19.295 22.161 15.355 13.49 21.597 27.906 28.312 32.555 36.855 18.076 16.406 19.626 23.232 16.078 22.236 12.856 32.593 21.405 21.905 20.199 18.307 21.999 31.123 33.52353 35.19492 30.07539 40.29552 26.23041 38.48692 22.66249 22.58756 19.19884 34.47119 34.58814 37.09544 29.17024 35.44334 26.99075 13.22095 32.83443 34.01337 33.75026 42.34086 41.60634 46.24915 38.83031 40.82201 45.0277 40.20789 17.25467 18.23899 13.5631 21.80644 18.25077 33.22091 27.01441 27.52192 24.4146 26.18002UKPDS33 Intensive 9.9209 11.567 8.9666 7.3778 22.481 16.845 13.75 20.252 21.469 5.9306 18.021 8.3755 13.62 25.523 13.279 21.563 16.842 25.693 29.859 27.102 48.374 53.194 46.236 49.011 43.378 30.947 39.597 45.211 22.309 22.092 28.781 24.337 32.361 33.461 35.164 30.958 33.267 29.412 30.243 29.072 14.004 18.4 5.882 15.535 11.593 13.378 19.551 16.665 23.987 23.567 11.089 6.6215 11.106 10.896 18.277 12.87 16.757 19.121 16.311 10.836 14.716 12.052 8.723 22.66 22.18713 22.81032 23.29195 17.52691 19.83347 19.68946 36.78836 48.66079 44.88712 46.76087 40.41662 46.68597 46.10053 42.76746 18.27661 27.01638 18.27117 20.07734 23.78032 31.59603 29.50407 26.57366 35.80162 29.12223 31.625 41.31305 7.454333 16.49486 10.37217 20.75803 10.40375 20.34087 19.93435 14.67622 15.87331 25.40965UKPDS33 Full 13.801 17.379 20.605 13.518 21.071 15.365 15.861 22.986 30.024 21.303 21.534 14.49 21.363 26.102 15.306 19.029 28.894 34.46 29.271 28.788 28.99 39.663 24.09 43.844 36.598 49.925 45.689 43.035 25.162 22.559 26.797 28.137 33.903 35.026 36.421 34.474 36.6 32.841 36.58 36.107 12.334 10.827 10.081 15.849 15.338 22.875 20.415 27.372 35.901 30.882 19.788 18.288 22.66 16.893 23.216 12.458 11.861 24.485 14.27 8.7388 14.332 16.798 14.124 20.251 19.20442 15.91239 25.02071 27.55646 28.15635 27.43958 33.53995 46.68913 32.88769 40.90189 47.05068 30.89849 39.74441 41.77824 19.99875 21.32849 27.91905 34.23523 30.27157 37.70196 37.64045 30.13108 38.18436 35.20906 32.40403 44.60335 13.89977 14.31121 9.882864 9.315511 15.0712 17.62772 16.87899 21.94292 25.44539 33.54797ASPEN All Placebo 18.728 14.958 19.71 6.8007 19.742 15.033 8.544 17.059 25.169 16.271 23.617 19.767 22.55 19.352 20.791 14.612 11.214 21.777 23.071 20.463 34.627 18.412 16.748 20.803 27.523 15.898 19.812 25.947 11.336 13.5 11.853 10.794 12.942 8.6603 9.9121 11.478 17.734 11.895 8.2614 16.039 17.958 19.666 20.408 27.618 22.028 16.583 15.851 9.0277 13.647 17.479 15.443 14.916 13.388 11.597 18.848 20.67 18.615 19.526 15.305 13.73 14.807 15.264 16.837 15.78 9.987492 11.67262 19.94367 18.01388 14.74788 24.5 25.71964 24.5255 22.07374 25.64664 26.33913 21.13646 22.61637 27.3633 8.930286 14.77329 15.17399 13.87444 19.9374 12.41974 15.04992 13.17194 13.00961 16.9632 11.68332 16.7556 16.36307 15.40292 20.2608 14.75635 21.87464 9.785193 14.18626 14.45683 15.34601 14.45683ASPEN All Atorvastatin 18.276 25.426 23.717 19.033 41.707 30.533 24.515 25.03 23.606 30.004 21.989 24.094 25.758 25.681 20.827 23.345 19.824 28.64 20.821 18.255 27.263 32.152 28.134 31 44.931 38.22 33.534 33.756 16.225 20.18 10.025 17.769 21.817 16.47 16.837 18.987 19.429 15.141 15.74 21.743 26.707 24.804 23.329 27.322 24.31 15.322 17.168 21.196 21.668 18.426 15.732 16.078 23.098 12.155 17.861 17.044 17.139 18.788 12.278 17.671 21.668 15.708 18.782 15.922 15.94522 18.46619 11.0227 10.79352 13.50926 21.17782 23.97916 25.68073 24.25387 25.89401 26.65521 19.27434 26.07202 21.0891 16.77796 11.7686 9.246621 13.81123 13.36039 10.12423 14.36141 13.38843 9.759611 15.37856 17.0147 12.10372 12.82576 17.29884 16.31717 17.38534 28.28869 12.4298 9.578622 13.87444 14.02676 19.48076ASPEN Primary Placebo 28.262 21.829 13.379 23.351 17.168 21.477 15.969 23.452 24.723 22.023 34.673 17.93 24.026 21.136 18.574 19.222 17.678 22.051 18.534 25.952 35.071 32.734 40.109 37.809 26.429 37.928 37.37 33.604 19.602 16.568 15.256 22.187 18.828 16.132 11.958 11.64 21.207 18.628 14.891 18.007 34.471 23.318 23.377 25.48 30.976 15.508 18.615 22.544 21.937 24.688 24.97 23.817 15.313 30.36 26.311 26.566 27.902 23.843 32.222 30.716 35.882 29.069 28.627 21.184 20.57304 17.03673 13.02881 17.05872 22.16416 22.78706 30.42614 33.45893 37.35974 36.4863 34.18333 39.83403 31.51587 28.46928 18.06239 15.19046 16.89675 18.01388 21.80023 20.5548 14.73092 14.79865 15.59647 14.05347 12.09339 15.10794 17.60682 22.43881 27.04626 33.84893 26.1247 19.65324 29.71952 14.07125 21.36586 26.73013ASPEN Primary Atorvastatin 25.055 19.761 31.619 25.065 27.051 30.927 25.788 27.249 28.723 18.561 20.676 24.31 30.471 18.069 18.049 20.056 28.557 19.526 26.201 21.886 36.946 30.615 24.885 35.658 48.047 35.054 40.611 34.623 27.937 20.255 18.514 18.419 19.634 15.867 15.289 14.95 20.457 12.39 13.124 23.659 25.323 22.045 23.728 37.977 31.405 17.428 19.786 17.578 19.039 30.765 13.36 16.666 14.44 13.62 19.532 14.824 21.743 18.574 19.118 15.182 21.943 18.152 16.279 24.218 16.57558 10.12423 19.51922 16.5 20.21757 17.95828 20.70024 33.74167 35.26684 20.6942 18.8016 25.83602 27.17996 20.76656 13.41641 17.61391 15.70828 23.77499 15.24795 9.656604 15.01666 14.48275 19.66596 15.83509 14.5 14.13329 25.03498 19.98124 28.95255 10.98863 28.79236 14.62019 12.57975 18.73499 17.47856 19.43579ASPEN Secondary Placebo 36.435 21.628 18.987 18.392 21.407 32.384 16.332 25.402 22.738 19.856 22.858 28.539 28.465 21.645 11.247 16.477 25.564 22.433 15.564 23.617 21.389 17.464 18.748 18.432 20.39 31.788 15.867 26.944 39.291 30.307 30.042 28.883 38.347 20.218 21.737 20.609 17.464 29.125 19.416 18.534 26.725 20.603 22.282 29.908 17.241 31.678 31.643 24.031 27.785 33.249 23.796 21.29 21.972 17.923 21.142 31.377 24.587 21.869 28.627 20.062 18.708 21.72 31.639 20.694 19.94367 18.05547 16.66583 22.67157 14.57738 30.21589 15.53222 17.21191 15.90597 19.05256 25.87953 34.0551 18.50676 22.54994 33.84524 37.10795 29.87892 25.87953 37.3497 21.03568 23.29163 19.39716 25.224 33.58943 20.70628 16.80774 21.37756 23.64847 19.8809 28.90069 14.55163 21.48837 31.72932 24.38237 32.85575 23.25403ASPEN Secondary Atorvastatin 20.292 24.845 24.89 22.444 16.023 20.421 19.261 20.261 18.358 15.508 12.227 12.669 27.595 34.18 24.91 29.466 45.044 36.159 26.472 32.427 25.164 17.132 25.676 23.838 28.718 36.565 21.296 25.632 14.37 17.4 12.99 21.731 32.5 14.124 6.9821 20.555 23.2 24.094 13.509 16.823 24.955 19.384 26.847 29.026 23.011 16.263 21.628 14.23 28.262 21.703 21.178 7.9057 15.108 13.955 16.837 22.622 7.7298 19.609 9.6437 10.283 15.411 15.652 25.431 24.31 19.36492 41.91658 30.02499 24.64244 10.97725 27.66315 9.513149 9.013878 17.57128 14.7394 11.09054 27.79838 12.90349 16.46967 16.74067 14.00893 10.06231 24.5204 28.11583 17.0147 7.5 15.47579 15.67642 19.48076 7.36546 27.43173 11.86381 19.38427 23.33452 25.01 16.62077 11.80042 10.87428 15.52417 34.49275 17.30607ASPEN Full 15.186 6.4129 10.302 12.966 14.427 13.053 8.8388 18.224 16.458 12.384 22.575 9.3608 16.602 17.281 7.673 9.6631 9.1173 21.439 18.698 16.051 23.883 19.586 13.505 13.148 19.548 24.599 24.731 18.183 13.233 13.091 5.534 16.617 17.752 14.921 14.392 5.2321 9.5851 19.439 8.3141 17.871 15.285 14.366 13.346 15.012 25.615 14.031 10.398 6.093 7.5416 12.821 9.9058 14.659 17.084 14.987 18.169 12.545 21.251 20.625 8.0545 16.9 16.96 10.788 15.776 16.237 7.945124 8.696264 9.829802 13.41175 16.15163 11.09617 18.944 25.09233 20.6791 23.74605 23.577 12.83063 22.48611 17.36016 9.931012 11.77391 7.27152 18.07968 14.44386 7.721723 9.387492 11.69936 11.12991 12.46495 9.585145 18.27909 17.11359 6.661456 14.67566 20.75753 18.36096 11.46189 12.17066 16.09736 18.87127 13.62443ADVANCE Standard 47.506 57.988 55.213 54.352 64.557 51.108 59.33 57.614 33.671 51.022 40.267 29.328 48.277 41.595 43.5 55.843 38.253 52.773 46.383 55.319 69.632 56.87 70.452 67.819 67.419 60.455 46.695 62.493 32.628 14.687 18.902 32.344 20.736 17.259 34.469 21.709 41.6 36.251 25.422 25.391 41.407 33.528 32.118 47.371 51.608 21.223 14.852 26.189 24.951 41.778 29.554 38.68 43.227 29.079 39.106 42.117 38.569 47.829 33.827 33.774 25.051 32.768 40.302 34.709 39.47694 37.53475 30.78265 39.23737 30.67572 42.79686 46.01397 35.55479 44.60141 44.5357 42.0272 55.69304 41.42808 64.11597 18.92466 14.11686 21.28715 25.57622 35.41388 16.42298 11.79588 7.416198 21.25021 20.17424 6.77179 33.56869 41.18252 30.90076 36.63722 33.97478 25.55945 9.561829 6.279217 20.6778 39.58174 27.16353ADVANCE Intensive 64.295 49.845 76.751 62.371 57.927 60.38 56.294 62.628 23.299 41.756 40.859 40.1 50.396 41.158 42.017 56.967 44.878 59.781 42.509 47.038 54.492 50.357 52.811 66.874 62.457 56.731 62.054 63.265 24.991 20.973 31.129 34.507 22.447 34.178 12.101 25.671 47.933 41.725 20.73 30.458 40.485 38.502 46.222 53.195 45.006 31.085 22.662 26.899 38.892 34.084 35.333 35.543 24.116 31.471 41.326 35.507 29.13 47.073 25.837 27.888 31.516 28.224 38.737 28.777 25.60134 23.25019 37.95862 35.80902 36.85493 41.90124 42.61288 36.5904 46.86759 48.12038 50.39416 57.54874 42.65309 36.86462 20.26256 13.03293 20.36103 21.18962 12.74475 8.518887 14.74061 24.12764 21.02719 22.8567 16.5702 18.9473 32.14921 29.3355 29.3355 31.90163 35.08968 32.92632 19.02254 19.84223 18.89444 20.02498ADVANCE Asia Standard 66.355 58.244 41.785 43.722 68.608 63.073 53.692 47.367 23.829 21.312 30.695 26.298 15.862 37.481 38.168 39.24 32.462 37.374 31.912 39.136 63.567 70.606 60.198 62.567 50.569 72.643 59.149 65.328 18.363 11.082 11.645 9.757 24.008 19.89 19.606 30.338 18 38.314 29.234 32.274 25.152 26.833 16.565 26.42 20.577 8.3785 9.9599 13.993 13.327 12.681 38.701 31.645 38.629 50.468 41.864 35.676 35.892 29.786 16.267 22.32 16.205 16.535 30.939 39.696 34 33.94702 34.44706 25.20317 34.44996 52.72381 45.65742 45.46647 41.64373 41.2068 59.29081 43.90444 44.79062 39.33192 15.11952 10.92703 12.48199 10.82589 24.07904 17.32051 23.16031 23.16031 26.79552 26.85889 15.94992 25.54604 14.66288 19.77372 13.38656 25.56951 20.83747 12.00833 9.476286 4.538722 11.82371 5.366563ADVANCE Asia Intensive 53.918 58.964 63.998 56.296 68.148 54.858 52.148 73.71 27.961 36.105 35.688 17.407 33.193 40.272 36.412 32.23 56.921 56.91 43.188 41.4 61.33 69.482 61.8 66.342 71.103 68.833 58.164 59.716 15.199 19.391 11.305 12.239 16.118 37.561 23.622 48.079 31.806 27.419 19.657 34.511 31.768 42.112 33.091 37.515 30.496 7.7846 15.434 11.305 23.264 15.792 42.546 42.995 27.893 27.287 30.312 43.474 24.091 31.847 21.114 16.358 22.694 24.69 29.634 33.211 31.28578 31.97812 46.13675 40.89254 33.58273 38.50195 46.98936 44.92438 41.20437 52.08839 36.58688 51.57519 38.87673 46.68833 22.48555 11.41928 7.014271 12.86079 24.91184 15.06652 18.85206 19.02104 23.68966 13.73317 24.68603 11.48042 22.44103 33.06962 23.61356 26.14957 19.0683 15.76705 15.20526 11.97497 24.75884 1.788854ADVANCE EME Standard 62.2 56.706 57.29 65.003 76.042 83.53 55.415 66.351 55.4 76.085 77.162 58.554 64.067 57.46 56.127 44.933 47.274 62.849 49.771 71.311 72.746 73.207 80.652 77.612 100.8 76.202 79.755 87.843 46.02 41.9 27.528 60.544 56.793 33.592 41.068 47.487 44.797 57.815 49.169 66.927 77.226 69.275 54.938 76.341 67.543 54.329 53.907 36.434 62.698 67.073 57.651 56.84 57.131 60.055 54.297 58.294 48.409 72.558 48.559 46.562 55.105 44.627 61.304 47.318 46.42629 44.71241 45.87374 59.36834 39.77688 57.87918 72.03471 66.90142 64.21682 74.64449 77.05323 57.8256 57.66281 65.96969 33.76389 42.65443 26.16486 43.4304 51.15076 46.34221 24.4663 23.74447 41.67253 38.04997 31.02902 46.10206 59.96832 57.04384 58.47906 69.16936 61.28948 41.65093 38.20733 41.12907 40.58325 52.32017ADVANCE EME Intensive 86.633 69.307 70.818 70.419 69.997 68.257 70.061 94.739 79.637 66.756 56.189 61.563 77.227 57.682 50.933 71.574 65.24 76.003 54.975 75.693 76.438 72.378 84.907 77.178 96.653 85.255 84.976 107.04 50.709 43.327 42.956 59.516 65.109 50.752 40.8 25.179 60.934 56.512 43.69 59.558 75.986 71.681 70.566 89.269 71.602 49.808 62.044 50.214 68.724 65.529 48.293 53.17 42.939 38.771 46.122 57.214 46.426 61.444 56.909 61.649 53.572 49.169 68.179 39.054 39.31158 35.72954 44.58251 56.31696 48.52834 54.98182 60.33904 49.38623 65.24722 53.36291 72.58512 79.54998 38.28316 82.81787 40.69644 40.26661 43.71727 46.18225 40.08491 37.82063 27.79209 36.18563 42.06186 30.94188 35.08276 40.10985 72.65122 61.4817 62.71682 65.59726 54.70283 42.96277 33.53207 36.20773 40.67677 55.75661ADVANCE Eastern Europe Standard 44.423 46.964 52.09 56.764 60.727 53.192 40.447 61.91 54.659 61.926 49.342 41.711 67.692 42.207 39.189 32.367 36.219 57.99 27.041 55.986 62.346 63.203 44.123 51.348 71.663 57.616 48.475 65.838 14.142 11.705 18.778 43.442 51.728 11.933 16.535 17.983 35.819 30.189 30.659 36.905 55.391 52.492 51.763 67.738 61.995 29.333 30.223 24.633 42.176 36.761 35.808 55.611 32.212 17.292 47.083 35.816 30.848 56.784 59.395 33.767 35.443 31.238 52.663 31.174 31.69543 40.6694 32.08115 44.20633 31.00645 41.93567 34.99429 49.45301 41.36182 52.40801 56.23878 69.34119 46.24284 66.30988 10.87198 12.05819 15.9875 31.70489 27.7092 8.988882 16.41341 18.6494 30.09651 19.32356 20.02498 24.61707 52.43472 35.28739 33.09381 54.65711 46.5532 18.17691 16.04369 15.78607 25.34956 29.27798ADVANCE Eastern Europe Intensive 63.465 54.345 46.219 59.095 65.839 65.746 48.757 65.786 55.998 24.352 39.704 50.381 60.414 28.723 42.071 58.689 54.452 66.866 45.943 41.002 63.422 47.168 64.786 66.135 83.41 60.065 73.547 80.207 26.9 16.697 28.046 49.394 48.726 29.117 34.044 18.493 29.98 35.93 40.696 57.893 55.688 54.834 44.089 65.854 65.408 25.448 35.457 18.601 48.734 62.645 20.533 26.161 23.778 28.217 41.161 29.725 28.719 42.783 28.26 32.299 38.613 33.281 45.372 32.769 33.51119 30.25558 19.00526 43.63026 41.97857 35.52745 48.63538 53.7829 44.40045 39.9975 58.68219 31.72381 62.89038 60.58052 18.89974 21.07131 15.44668 38.60311 27.50273 9.97998 13.60882 6.244998 25.27845 14.22674 21.73937 32.64966 27.20662 18.55802 56.77147 50.16373 52.72191 16.04992 14.29685 24.08734 36.35932 28.32314ADVANCE Full 37.867 49.677 44.613 51.244 56.625 43.77 42.639 72.98 56.567 45.178 46.879 49.65 66.593 46.829 50.379 50.004 42.919 53.893 56.067 58.076 70.32 79.124 70.971 51.276 71.669 75.489 66.505 73.266 37.587 19.2 28.699 42.094 40.842 32.119 35.576 43.092 42.819 45.278 42.62 58.696 54.271 60.871 51.511 56.636 55.428 28.454 30.927 14.214 41.208 50.778 27.264 42.821 33.854 32.758 46.981 40.581 36.796 47.464 62.579 40.2 44.376 50.924 42.893 36.108 48.25903 43.66677 40.81227 55.13304 39.03017 55.35414 50.60992 49.97506 45.13079 34.78393 45.85928 58.47172 48.43484 51.85082 32.6703 30.1293 17.44112 50.36938 38.42889 19.16231 14.89645 27.38196 27.70865 49.04304 24.69643 37.80676 50.05219 56.15232 55.37351 53.66902 42.2991 32.94898 31.79945 39.99551 31.54456 43.85439ACCORD BP Standard Therapy 39.663 52.236 62.209 44.658 46.8 64.068 45.7 58.773 41.106 41.27 49.68 41.207 59.746 54.324 50.431 48.797 51.67 59.437 59.228 67.685 55.698 52.765 60.915 53.715 51.831 63.254 66.038 67.187 36.625 41.478 40.649 50.946 57.773 45.713 45.214 47.461 50.573 56.187 47.86 42.414 53.129 46.29 47.197 60.286 51.965 41.016 39.679 39.189 57.188 44.842 43.846 42.803 49.054 53.79 50.254 61.599 38.95 51.836 43.567 44.279 49.557 41.636 60.357 59.068 63.09756 53.36588 59.82507 57.74548 56.0604 60.37507 53.84697 61.18766 58.7087 56.85903 42.95179 60.83377 53.91216 54.68165 34.52606 31.39912 45.46286 45.06671 54.48609 37.43555 44.03754 49.0809 46.50134 55.2022 37.24087 50.62645 41.95631 54.11239 45.08539 57.92412 52.0882 39.2801 33.37011 40.92891 66.97515 43.16264ACCORD BP Intensive Therapy 38.501 43.179 54.278 43.943 57.022 53.488 56.192 52.165 44.685 36.752 35.563 49.113 67.268 46.258 45.203 61.914 54.686 58.258 42.979 63.509 59.398 48.095 53.454 57.366 71.858 58.294 48.656 62.344 31.294 35.084 39.695 38.368 44.263 35.475 45.243 41.116 42.575 53.884 33.434 59.392 43.848 56.944 35.498 58.071 37.212 31.657 41.148 32.422 55.309 42.579 34.195 35.936 42.994 42.236 50.318 47.706 38.588 53.055 43.258 23.619 38.273 40.841 50.831 34.015 41.93353 41.16953 49.84724 56.41206 44.71246 51.65144 28.53475 30.80471 42.06139 40.17586 45.10157 38.25995 29.39693 42.37776 37.1113 37.02059 33.71171 46.15297 46.54236 31.02187 27.62513 36.91642 36.33782 44.57518 38.64834 50.55192 35.25795 38.71664 37.54194 52.34051 29.30084 29.83799 30.41647 34.52754 42.78197 37.83079ACCORD BP Full 48.886 43.179 57.444 53.715 54.137 55.247 51.351 49.873 39.712 32.433 51.586 46.156 61.969 55.743 63.368 48.76 47.809 61.252 56.582 65.174 55.413 54.565 55.061 61.874 75.485 67.907 42.005 69.109 36.565 33.807 35.651 45.268 58.277 37.577 38.037 41.21 42.037 64.119 53.349 51.238 41.723 40.63 48.983 68.612 49.145 36.79 42.953 40.149 55.794 44.361 39.127 41.785 44.754 46.915 56.293 62.027 45.988 39.103 41.036 31.67 55.298 47.771 52.262 47.047 50.63383 52.22284 56.61367 53.90855 42.96476 58.48467 41.75387 44.97807 42.94205 43.66469 51.05981 53.11276 47.6859 54.55997 37.36272 35.50154 38.90312 44.96484 44.26273 42.36062 38.45213 36.47209 48.9023 46.39214 39.77541 44.48023 43.95849 46.38778 46.49311 50.12646 39.69487 28.72887 33.16661 38.21615 51.11573 45.28257KP 20-34 9.5786 6.2249 16.21 12.43 11.091 10.416 8.6891 10.782 9.5 11.158 9.2601 12.99 12.835 11.158 14.44 13.647 15.827 11.822 13.666 9.7211 14.569 15 22.226 9.6825 14.824 16.34 12.47 12.58 8.7034 9.2601 13.332 14.448 12.42 12.52 11.068 12.669 13.248 10.954 14.62 12.43 7.5993 11.214 12.43 10.886 9.8362 8.6891 11.5 13.802 12.369 10.332 9.9373 12.61 15.124 9.1241 12.268 15.419 12.073 8.7034 6.6895 7.746 10.571 11.034 11.906 10.025 9.246621 18.88121 10.21029 11.21383 14.30909 12.8355 10.79352 17.14643 17.13184 16.25577 13.51851 19.32615 14.90805 13.83835 5.894913 12.78671 11.81101 8.660254 9.823441 6.946222 16.88935 9.721111 16.26346 16.14001 12.5996 17.72005 6.30476 12.09339 9.513149 12.68858 7.449832 12.4298 16.17869 18.85471 11.06797 9.287088KP 35-50 18.641 25.283 22.147 18.661 22.011 28.452 26.405 24.213 22.913 29.24 27.143 32.07 27.152 24.088 22.793 24.729 22.344 26.641 26.125 23.335 42.039 43.937 38.714 43.442 41.161 49.952 34.081 36.589 25.303 27.848 25.357 22.31 25.52 21.101 33.023 21.018 24.346 17.059 27.477 27.875 20.579 34.081 30.85 25.005 25.593 20.555 26.851 23.103 23.13 28.062 17.84 28.377 33.47 27.897 24.693 26.972 27.825 29.787 24.713 22.528 20.037 27.032 17.168 18.561 27.75788 18.12457 21.43012 21.47673 26.35337 19.57039 50.88959 40.06557 46.12212 38.75564 47.26256 40.73082 39.59482 44.88597 21.43595 17.75528 19.98124 20.79663 24.82942 25.20417 17.25543 30.37269 17.63519 30.4836 26.73948 30.52048 25.76335 28.82707 36.15591 29.6395 24.5153 31.47221 30.83018 27.39526 24.80423 21.87464KP 50-65 41.479 56.323 59.064 50.085 64.37 51.337 47.718 59.405 44.975 59.435 45.632 51.442 54.014 46.489 42.65 47.568 66.972 53.81 47.233 54.268 68.536 80.47 82.526 77.618 84.364 90.579 74.751 78.202 42.314 32.646 41.225 47.755 46.179 28.346 38.292 34.565 50.302 46.193 46.749 50.929 54.429 48.629 44.623 64.861 53.061 46.163 49.028 43.903 44.866 46.837 50.779 49.015 46.699 50.381 53.638 57.775 52.721 54.502 44.187 49.93 58.647 55.464 61.589 46.419 49.26967 49.33052 42.92435 57.12705 55.13166 62.80923 80.63343 77.26092 65.73622 74.44125 81.23577 80.68147 87.00862 77.41608 29.80352 43.00872 31.73326 51.83387 49.82469 29.79513 40.92371 39.13758 45.8503 38.87801 40.62635 52.86303 48.56439 61.4451 52.31396 63.16051 55.96651 37.52999 42.64094 51.74456 45.11375 60.79062KP 65-75 72.827 75.849 79.961 90.978 81.59 108.21 80.425 87.172 74.748 91.699 83.561 100.96 114.25 87.918 92.058 95.082 96.446 96.781 100.15 109.53 94.939 97.117 87.079 109.82 92.349 109.08 75.791 98.871 67.829 59.002 84.27 84.898 90.069 58.004 65.856 81.655 80.553 93.113 73.469 85.131 74.128 90.264 88.935 115.47 90.678 67.088 71.99 82.623 73.012 82.175 68.982 78.278 89.758 90.768 93.611 90.838 75.13 106.81 72.248 76.821 86.481 93.531 110.93 85.087 78.24002 70.42372 115.5617 103.5833 91.90892 112.8317 90.25381 78.09289 108.2335 98.55709 82.21314 105.0274 85.65337 88.0284 62.91065 55.03181 79.39616 70 99.0568 65.09224 55.07268 88.73697 81.5935 98.30437 68.15424 77.66756 99.77475 95.13937 112.5722 113.5859 94.04919 69.57909 74.47483 88.38835 101.3435 84.91614KP 75+ 125.89 119.96 120.64 152.26 136.99 138.95 110.35 107.62 148.9 130.45 126.73 170.14 143.28 154.28 142.26 139.66 176.27 158.43 156.34 171.77 109.8 90.313 89.489 120.88 101.63 133.03 100.44 106.52 122.97 117.85 153.37 120.47 126.57 131.61 129.12 156.63 133.9 139.23 111.68 139.46 139.45 148.37 149.09 160.29 131.96 124.41 106.28 139.15 133.82 121.07 125.93 109.5 102.42 139.18 149.56 156.13 105.79 133.78 153.2 133.37 137.64 150.85 148.53 173.32 134.6737 146.8954 176.8198 162.4731 150.6469 148.0827 111.5572 94.94472 84.39194 123.2933 101.7571 119.6296 88.03124 107.9641 126.7655 121.064 143.7167 127.6626 141.0496 140.9264 129.1878 152.4238 126.7902 144.8249 113.6299 145.6082 149.6554 136.9881 158.1977 161.6184 136.2011 121.9436 103.3671 144.0477 123.8134 125.994KP Total 57.085 58.401 54.534 69.42 78.841 73.695 60.805 75.375 61.475 66.652 71.69 75.757 73.092 64.721 72.795 69.085 73.101 75.673 68.943 67.68 67.982 64.475 81.102 79.379 69.721 77.445 66.857 79.507 52.126 56.335 59.948 61.502 70.301 49.907 51.387 68.454 58.994 58.079 58.963 70.252 67.038 52.455 73.321 70.269 79.325 59.195 50.997 64.484 62.938 64.22 59.028 58.718 63.266 67.215 79.844 64.63 60.243 78.549 64.648 51.796 69.535 69.223 79.969 75.301 71.16356 75.05354 72.07208 74.00638 61.02019 67.64988 54.75018 78.0044 58.47601 88.21379 81.51017 93.02931 68.20729 85.44532 49.03401 52.99232 64.16167 52.61954 71.75664 61.78986 52.43389 56.15554 60.05512 66.66797 57.01654 62.61913 57.27068 75.70524 66.4619 85.21527 58.09295 46.77928 64.36105 61.24258 65.59108 66.11525NDR 20-34 8.5147 9.2195 10.124 12.59 13.892 11.068 10.817 14.089 14.16 10.607 19.455 14.714 11.853 8.6023 13.21 11.511 12.349 10.512 17.335 12.083 20.518 20.555 20.591 17.464 27.613 15.264 20.591 14.916 19.092 15.652 10.512 20.809 10.63 12.903 11.853 14.577 11.18 10 16.155 15 9.9247 13.946 12.083 9.6177 16.447 19.144 18.028 13 14.318 14.983 12.104 15.443 18.385 5.1478 15.443 14.422 12.349 13.21 10.817 13.601 12.207 15.182 13.416 10.607 17.39253 10.63015 10.5119 10.29563 10.19804 14.57738 23.33452 24.18677 20.70024 19.30026 20 21.27205 19.03943 22.63846 14.1598 13.94633 11.42366 13.0384 8.944272 16.98529 12.34909 13.60147 13.28533 16.55295 19.45508 12.04159 16.32483 19.96246 14.76482 12.90349 10.81665 11.51086 15.89025 16.55295 17.73415 13.94633NDR 35-50 20.159 11.67 14.327 15.871 9.5373 11.002 16.474 6.8789 15.914 26.202 21.13 19.285 18.698 7.3993 9.8939 5.8152 12.333 4.9747 10.147 11.469 37.78 25.326 37.389 36.788 35.593 32.871 35.301 42.487 17.285 16.095 22.385 15.477 17.474 10.91 8.5583 20.782 18.85 11.933 17.862 10.168 13.674 13.674 16.805 20.987 23.512 14.446 27.487 14.006 20.83 26.651 11.015 19.024 24.853 13.904 12.078 6.3776 14.645 14.327 9.5861 17.939 16.69 15.537 19.496 4.5471 13.66562 7.002231 13.51855 12.69828 14.60538 9.147472 39.21621 34.25398 38.3459 24.45347 29.43588 29.55218 28.38336 27.36869 22.93099 10.28699 20.38132 23.638 24.18175 8.886183 11.97169 8.789212 11.01137 12.76853 12.24309 17.67066 19.14153 12.5883 17.05149 15.74463 26.51496 26.50964 15.66273 21.09095 18.88609 16.35877NDR 50-65 27.464 25.24 32.149 39.106 39.603 36.312 36.675 43.955 42.059 22.874 34.109 37.39 48.659 29.336 38.989 32.594 22.042 37.859 31.492 36.663 69.625 60.495 51.273 57.485 61.333 63.057 55.483 57.363 25.144 26.859 43.823 26.408 28.946 19.791 23.185 24.528 29.253 30.548 30.132 36.104 38.092 51.033 40.286 51.688 47.14 22.984 24.69 30.446 35.596 45.816 44.183 36.312 30.083 31.2 31.778 40.673 21.208 42.686 30.388 41.599 42.757 42.982 36.312 29.944 34.58592 22.80899 27.03121 26.69528 34.01209 25.46955 63.99014 60.0405 53.98828 52.96337 67.8316 46.99389 56.17193 65.09545 18.74721 29.58604 22.94772 36.02541 27.57394 12.3563 21.73242 15.98456 31.14563 32.1081 11.93558 32.78759 53.37024 44.89016 37.01878 46.38627 39.92931 38.70041 32.87945 20.72684 33.6892 38.8159NDR 65-75 48.969 54.641 49.87 52.465 60.983 59.206 54.176 61.995 51.756 45.731 50.73 59.507 53.613 39.775 46.802 35.556 49.885 47.098 36.201 55.371 51.793 45.946 36.96 51.994 60.983 61.341 60.307 45.059 25.149 31.541 24.332 38.787 36.397 28.799 21.356 25.447 31.469 24.788 24.22 45.631 49.679 55.291 58.956 42.152 51.05 32.35 42.691 31.557 39.677 44.184 48.403 51.624 55.645 54.116 58.389 54.684 51.523 64.37 60.446 57.693 44.705 49.235 56.756 47.853 53.18656 43.4053 48.67042 49.4842 29.83149 48.48 56.74367 61.66596 53.24671 58.47037 70.5535 54.54072 57.06495 48.73299 33.07733 28.54992 29.67609 44.41802 39.80292 31.14055 18.86478 16.46311 35.65743 42.717 25.64258 43.54979 64.77998 72.99386 64.34338 58.45462 68.85726 38.63154 25.63158 37.48485 44.1598 35.07652NDR 75+ 79.257 69.089 48.495 66.785 57.625 73.422 64.07 65.018 58.343 32.814 44.617 64.086 58.731 77.955 73.614 65.029 59.828 72.571 54.051 69.506 35.259 26.639 27.274 28.345 31.874 24.817 18.766 25.763 50.641 25.623 33.76 18.296 23.97 69.796 34.202 34.752 39.359 40.324 29.886 49.327 57.044 57.662 63.179 64.086 77.834 62.73 45.997 29.042 41.185 41.158 53.201 64.771 66.278 73.475 59.183 64.43 71.781 75.524 62.175 58.887 55.595 61.069 53.89 68.037 43.16874 59.87061 53.0076 68.36969 62.62931 54.75427 47.29655 24.06217 25.84697 28.82683 32.59724 23.81732 17.09605 25.4538 47.25227 22.46586 23.31581 25.26206 28.24011 46.88137 34.15898 31.26004 41.6844 34.03686 32.1957 50.25222 73.55645 65.69882 66.53402 63.96304 62.6571 53.55895 27.12506 37.29167 36.35419 32.32709NDR Total 43.058 33.218 35.984 57.078 43.44 42.686 41.011 43.592 48.115 57.335 43.142 38.225 51.922 28.286 37.019 33.12 39.395 45.236 40.763 48.533 54.574 43.726 52.222 47.499 56.767 53.111 47.645 60.571 37.408 28.898 18.092 24.592 32.091 19.857 16.759 19.705 26.788 23.697 19.287 31.315 52.783 32.555 40.46 50.881 54.017 34.612 40.938 33.218 35.738 23.592 41.281 40.288 47.288 40.898 38.619 42.793 43.679 47.254 50.797 34.544 39.76 60.118 33.081 46.489 39.9059 34.5062 35.98985 45.87663 40.30553 42.48057 42.90356 48.70174 38.19072 54.02893 59.8035 59.69498 40.22242 46.33394 19.67315 26.18659 31.15969 38.90535 29.33038 17.73669 16.36056 17.733 23.68099 24.67766 16.8942 34.26302 51.53954 50.82945 55.12317 55.2249 53.2442 37.24369 33.96317 23.097 32.53607 48.23595AHEAD Control 70.932 69.883 64.859 60.769 83.678 72.747 58.605 79.179 61.43 79.018 87.756 72.878 81.876 76.02 74.346 75.75 93.065 94.463 78.257 93.743 88.669 89.833 89.627 115.91 108.45 102.07 106.46 106.01 56.887 53.129 53.061 58.073 53.141 79.005 60.02 61.866 65.754 82.103 56.247 66.421 76.79 77.66 76.686 79.947 77.866 52.557 53.307 65.963 72.402 62.851 47.012 48.351 60.868 66.883 68.954 60.66 63.293 62.003 61.525 59.203 75.383 71.2 68.384 82.207 77.2744 75.4214 83.20829 95.01568 55.13534 83.31883 86.41313 69.70303 88.80189 101.2906 81.20946 101.5044 92.80234 102.551 52.64744 59.14396 73.70755 57.16382 65.409 58.91981 53.53396 66.66848 74.52231 73.31617 48.78896 68.91542 52.12094 80.11895 65.31537 64.85177 69.89072 51.00029 53.17066 51.74519 73.57255 71.56379AHEAD Intervention 77.084 62.48 66.244 70.609 73.371 96.76 71.308 86.411 78.272 75.02 79.306 77.785 91.082 71.852 77.128 95.205 83.222 100.32 82.891 97.524 102.34 82.17 88.294 98.961 110.65 108.44 106.19 93.998 55.146 42.788 62.615 51.57 65.672 57.577 58.031 63.883 58.084 74.08 45.382 68.206 67.866 70.503 81.605 97.552 61.673 61.048 58.164 58.253 70.921 66.385 53.284 58.972 64.362 57.024 72.45 66.132 47.796 65.18 61.916 65.724 61.68 76.571 77.42 56.819 57.97596 76.33954 78.06035 77.3327 72.93919 86.25006 99.93964 90.07775 80.81177 90.83674 77.15249 99.07846 94.00278 86.30873 39.24546 55.61202 52.14535 51.22253 62.70044 55.52815 66.29899 52.4305 82.52974 64.20305 66.64922 55.59278 57.27973 68.46805 87.63542 76.96896 73.35495 55.93869 56.68382 56.99322 55.29891 58.03291AHEAD Full 71.284 74.857 73.654 75.615 76.566 82.247 73.587 82.891 77.795 83.698 72.813 79.59 84.991 84.123 90.289 71.723 79.82 94.327 72.427 85.081 102.45 105.6 108.63 104.75 115.52 132.97 97.908 107.75 55.549 55.445 70.58 62.043 73.802 55.767 63.702 72.162 79.177 75.443 74.76 67.729 76.631 85.119 99.892 82.779 80.587 59.625 59.196 64.208 69.774 71.871 62.661 69.248 60.194 61.244 68.8 77 52.06 84.247 70.451 74.563 68.133 77.641 82.609 81.567 72.83978 73.17806 73.00988 78.37396 62.73755 74.57664 88.25704 72.79475 81.82338 81.38222 93.73673 89.99672 89.99018 92.01466 48.13727 52.18478 51.30918 58.77476 74.86892 65.82568 47.85216 61.3031 62.95515 63.03293 55.75211 61.89969 78.8821 67.45445 74.9856 70.09205 75.48924 70.07004 47.38219 67.88298 69.38271 65.09727ADDITION Routine 41.803 48.485 61.486 50.205 63.02 51.24 53.505 57.151 43.399 52.242 53.35 54.615 57.232 36.949 38.949 39.462 28.836 41.743 42.997 47.297 92.903 96.946 79.546 85.917 79.955 85.905 72.744 90.608 27.622 33.053 38.965 46.556 49.409 26.462 31.949 26.472 39.316 24.362 29.034 36.773 52.398 51.786 42.793 61.247 56.582 38.125 45.667 41.911 43.491 47.26 17.27 27.308 22.517 18.289 37.33 23.822 23.179 31.329 29.013 40.488 37.091 35.415 47.789 14.79 28.19574 24.09876 18.91428 25.41161 23.02173 38.14446 54.32541 59.10584 54.28398 59.10584 50.97794 61.84658 54.307 47.66288 25.23391 28.95686 31.233 28.24447 39.22053 13.22876 19.18984 19.37782 23.17865 18.47972 13.72953 17.55705 41.17645 32.14032 33.95217 36.89851 42.24038 18.30301 31.83159 31.97264 39.53479 39.35416ADDITION Intensive 48.036 46.707 44.931 53.645 53.607 49.772 56.013 60.254 56.749 51.032 51.218 43.076 49.216 36.817 45.708 35.784 36.8 50.926 55.709 56.646 81.532 89.803 93.404 81.837 94.11 93.136 80.737 98.395 36.79 41.527 46.704 48.14 38.775 29.043 26.977 21.201 38.613 35.718 35.627 40.725 59.205 50.274 60.287 77.685 58.425 39.303 46.027 35.623 52.835 55.322 24.088 31.918 35.658 28.062 31.674 28.588 30.112 37.36 43.191 36.5 44.334 37.346 35.461 21.506 31.87868 25.56854 21.77728 33.35041 42.95637 50.26927 63.14665 56.59284 64.70317 48.09626 61.54267 57.81652 62.98016 64.04881 36.10402 26.49056 29.16762 36.44859 28.25774 15.19046 15.07481 18.20714 30.6635 28.32402 34.0147 28.52192 44.39313 44.37623 41.2977 45.10543 48.05726 28.8184 38.72015 47.326 36.18011 34.11744ADDITION Full 35.644 45.747 58.691 59.592 59.096 46.046 52.037 60.706 49.131 58.102 47.682 53.356 54.088 38.045 27.214 33.219 31.026 47.646 33.916 44.67 94.656 84.679 77.888 86.753 102.93 88.553 95.466 100.96 35.565 40.019 38.522 53.161 42.855 20.733 35.936 21.304 37.132 35.932 28.013 47.624 46.064 48.261 54.968 60.867 48.195 40.934 53.757 45.137 52.941 50.793 26.683 27.648 28.799 28.142 37.058 31.893 26.095 33.456 33.77 45.811 26.623 43.331 46.583 22.275 20.24825 18.05351 21.73631 41.78521 24.84483 28.12747 56.99514 49.9509 50.53629 54.40331 62.83326 53.58532 53.83199 62.30456 29.92634 28.6043 35.14352 30.07006 35.85275 14.73212 20.32227 18.57066 30.33172 25.60018 22.30238 33.64528 32.95458 41.48538 40.83987 43.0981 50.13957 33.31616 33.32031 36.23743 33.7911 35.88UKPDS33 Conventional Correlated 25.045 35.017 29.24 31.782 41.778 38.2 29.777 46.879 14.656 18.466 16.524 15.451 21.38 15.477 20.774 21.087 21.206 44.867 25.113 36.785 67.057 63.527 65.243 67.976 66.818 62.605 63.007 75.907 20.076 19.36 22.985 35.261 29.451 32.363 27.763 29.438 40.486 33.573 27.943 39.681 15.251 10.461 17.164 27.631 20.637 10.782 12.93 16.641 21.007 37.987 27.212 37.122 34.794 39.19 43.591 33.615 34.259 43.218 11.957 17.888 20.694 13.731 29.196 19.395 23.0559 19.58786 12.08705 36.65801 21.28382 42.06195 65.88564 58.02905 66.05837 58.80761 74.29599 72.82883 63.51251 66.33521 18.73379 16.35771 17.31018 30.2672 20.60576 22.26462 34.73846 28.64703 30.5385 40.46111 34.26707 37.62484 14.55782 16.57807 19.91043 28.32552 22.58707 19.19956 22.54955 14.59012 28.08197 28.41862UKPDS33 Intensive Correlated 50.133 44.224 50.879 45.578 43.554 50.664 46.206 45.002 11.193 19.134 20.554 20.723 21.678 9.5029 18.384 15.375 14.287 29.95 16.176 31.852 66.06 71.948 78.917 77.151 79.939 76.491 68.262 78.752 15.176 10.647 14.293 31.278 24.575 15.16 19.314 20.303 33.296 20.499 22.94 37.002 16.231 25.284 19.582 24.58 21.928 7.4727 8.1061 8.1968 19.346 29.784 44.587 49.312 45.417 41.514 55.945 51.529 30.225 57.041 19.173 20.18 21.132 16.891 22.159 17.168 18.16631 9.126913 13.3797 23.27935 17.57847 37.65385 69.66731 75.92333 68.42288 65.67099 73.38624 75.63363 71.84168 78.851 12.31341 14.59015 10.48435 32.94067 24.1628 14.99384 20.29269 19.0969 37.93925 32.26874 30.32533 36.98932 15.93075 28.68016 23.85006 24.99085 23.68968 11.78643 4.292813 14.21463 21.94744 32.25956UKPDS33 Full Correlated 40.928 34.87 47.177 43.355 56.058 45.647 49.234 53.315 9.9239 13.371 12.21 17.386 29.491 9.9451 11.932 15.437 11.776 28.657 17.635 30.162 74.527 64.982 72.065 70.939 69.203 67.86 66.368 69.77 17.591 19.098 13.712 32.085 18.859 23.076 29.512 18.335 39.336 16.63 21.559 35.046 20.25 17.776 20.994 30.877 29.345 9.1406 16.278 8.8659 25.631 33.47 33.331 47.137 41.53 35.897 52.656 39.445 33.865 54.065 8.9625 22.232 11.778 9.2474 26.137 15.751 13.91752 15.44127 10.42857 38.35831 23.51628 26.89665 54.26978 66.6063 75.60898 63.5061 80.63836 69.66938 59.80273 71.08688 15.38244 10.53476 12.04383 34.26308 27.80266 15.01448 24.717 29.22879 37.03304 28.65065 29.52574 39.35585 24.24074 14.43726 15.82083 19.83764 31.10288 12.1353 13.77509 13.64712 20.60466 31.33154ASPEN All Placebo Correlated 45.875 49.066 43.041 39.869 50.351 51.875 46.511 49.792 34.304 32.829 30.008 32.098 36.708 37.128 26.225 26.125 23.89 32.133 28.592 28.539 52.436 49.186 48.772 40.666 43.94 43.414 47.721 49.115 27.78 15.969 22.254 20.094 21.296 30.749 14.739 15.66 13.775 18.908 10.428 27.884 35.69 39.538 34.893 31.725 29.202 23.157 15.223 20.815 30.891 33.365 55.489 46.06 40.611 51.839 52.856 59.962 45.415 46.559 28.018 29.504 35.795 26.561 31.468 34.979 31.08456 33.52238 20.21757 41.84196 33.93376 30.58594 54.75856 48.53349 39.03524 44.50281 47.71268 40.70319 41.51205 58.50855 22.41093 21.23087 20.16185 27.59529 30.52048 24.56115 12.49 19.9875 20.35927 23.98437 21.85749 36.43487 24.5815 29.09897 35.74213 36.84427 45.65906 31.58718 19.05256 29.43213 28.34167 27.27178ASPEN All Atorvastatin Correlated 54.923 56.42 51.344 50.51 63.101 58.801 49.825 60.733 37.865 33.845 45.686 28.853 40.401 29.762 37.699 33.612 43.766 36.756 33.478 39.099 41.842 54.143 52.628 46.677 54.884 52.17 50.826 44.054 16.263 24.845 20.676 30.781 31.165 20.457 16.47 18.187 28.513 33.384 27.409 23.885 49.267 39.793 32.226 37.36 28.909 24.109 25.705 26.467 32.346 30.025 48.515 41.806 50.946 37.383 50.022 44.255 43.629 44.908 24.693 39.506 26.462 30.054 39.221 31.448 35.21008 32.94313 25.68073 30.18692 21.37756 26.8235 39.98125 36.42458 43.41947 40.15595 45.11652 47.56049 42.08919 48.54379 19.55761 20.70024 22.88012 22.09638 22.52776 24.23324 16.38597 16.03901 24.92489 18.79495 18.04162 18.37798 24.87971 38.42525 21.78302 33.23778 38.48376 22.5 24.36186 17.73415 21.43012 24.18677ASPEN Primary Placebo Correlated 61.437 51.405 62.121 55.944 60.519 64.85 56.085 60.92 39.781 35.809 43.442 36.038 39.601 37.871 37.888 33.716 33.856 35.539 47.122 38.643 58.764 61.956 49.401 48.099 59.864 66.996 63.847 57.955 29.891 25.328 23.043 29.783 29.753 23.569 21.249 21.61 31.788 28.614 24.95 31.165 32.415 37.875 36.177 55.195 41.94 29.749 33.738 38.056 32.585 34.446 70.742 57.708 61.786 58.393 71.655 61.284 61.551 53.28 41.533 31.824 36.763 37.769 42.232 35.847 23.05428 27.16155 19.84313 39.16312 31.64253 36.36276 56.3427 57.79057 54.22177 52.57851 66.33438 60.79885 46.62885 50.0025 28.59196 26.05283 27.59529 27.35416 33.66749 24.01041 23.14627 34.7491 25.43128 28.08469 21.25441 26.83747 41.94639 43.14221 49.68652 41.00305 46.0923 31.13278 34.56154 30.51229 29.57195 22.41651ASPEN Primary Atorvastatin Correlated 59.552 65.198 59.044 66.144 63.902 61.029 65.843 57.528 33.667 32.411 34.154 39.392 39.592 26.669 27.102 29.47 36.349 38.558 27.884 47.077 64.393 48.875 43.494 50.316 55.675 55.168 54.21 59.163 26.41 18.432 30.467 25.734 28.408 24.187 24.723 28.736 28.697 23.356 18.131 29.458 46.144 31.867 35.85 39.972 35.843 31.504 22.616 23.292 20.652 37.845 39.437 39.922 40.367 45.117 42.72 51.887 46.859 41.067 30.992 31.044 25.234 26.636 36.125 37.057 28.53507 29.62685 26.98611 34.82815 32.14809 30.91116 44.87204 47.58676 48.64925 44.84696 55.09537 39.84658 56.62155 44.32832 32.93175 20.4817 25.54408 31.18894 26.35337 15.73213 11.46734 21.03568 18.88783 30.29026 15.40292 23.98437 38.43826 32.81768 27.19375 46.76003 35.14612 20.0624 24.47958 27.64959 22.24298 26.83282ASPEN Secondary Placebo Correlated 28.469 33.422 25.348 35.263 46.583 42.991 24.031 38.542 28.714 19.912 26.94 25.583 34.857 35.567 29.279 36.235 29.095 38.856 35.093 28.531 30.631 18.594 40.826 22.683 28.588 28.697 14.95 25.189 30.042 28.022 23.638 36.187 34.954 26.387 20.081 18.615 22.666 33.996 17.958 24.062 34.007 17.882 22.655 30.733 18.848 37.706 25.894 19.615 39.449 30.042 37.343 28.275 28.434 32.989 41.277 43.396 25.426 33.189 30.008 15.612 24.92 25.475 35.651 37.97 30.78149 31.91786 30.92329 39.2492 20.89258 33.13986 34.86402 26.65521 22.75961 22.50555 19.83683 45.13037 17.19011 34.85685 41.77918 28.80538 26.32964 27.48181 41.18859 31.69779 22.91288 18.24144 26.43861 31.42849 17.97915 25.0699 31.37276 16.92631 20.71232 37.89789 17.05139 32.58834 33.30916 24.91486 41.4367 28.5ASPEN Secondary Atorvastatin Correlated 50.693 43.592 47.085 51.227 45.615 55.286 49.684 46.266 34.619 39 27.299 31.627 42.924 51.098 33.151 50.227 48.997 49.412 47.069 48.278 40.945 36.118 30.895 40.481 32.265 45.853 39.994 42.03 30.212 21.249 16.636 27.762 40.231 45.158 14.534 35.341 30.455 40.583 19.685 33.593 34.713 27.861 25.01 43.362 24.3 27.641 21.272 14.335 43.099 32.488 37.878 38.856 27.942 38.409 34.993 58.784 32.234 33.489 34.853 12.01 21.095 15.017 33.481 53.512 35.58792 48.24158 34.67348 52.12965 42.13668 41.27651 32.38055 28.08024 22.43881 32.31099 26.11034 35.17812 19.67867 31.10466 20.30394 20.26697 20.03746 19.84313 34.16504 31.71356 14.22146 24.86463 31.33289 45.43677 27.07859 25.0699 31.12073 21.09502 18.77498 32.87096 16.57558 22.39978 18.41874 11.18034 41.25227 18.8016ASPEN Full Correlated 41.375 51.508 34.44 38.028 38.391 56.878 48.085 46.461 20.14 20.041 23.693 16.819 29.94 26.441 21.474 22.291 24.246 23.835 22.943 39.867 43.438 32.926 42.108 45.151 41.933 51.138 46.703 49.073 16.534 8.8388 13.005 20.673 23.203 23.305 16.458 11.264 20.497 14.987 18.162 23.057 47.206 32.317 21.246 33.588 27.652 17.688 21.051 18.911 21.694 23.476 37.012 43.109 31.351 30.568 43.254 40.378 35.565 43.097 30.465 23.31 15.839 11.974 34.269 28.985 32.79291 24.49235 22.26264 23.5876 17.02572 26.88169 46.62483 38.65715 34.53802 28.55039 33.38974 35.61425 46.65699 51.10651 17.39612 23.21368 13.34635 23.0353 25.08735 13.01442 10.0312 14.20827 19.67549 18.9374 13.00481 21.73419 22.12182 31.77853 22.90469 33.78794 21.83174 16.72947 11.25278 9.387492 22.80077 31.79819ADVANCE Standard Correlated 77.644 70.806 77.936 69.963 68.62 79.464 73.629 79.925 29.27 35.124 33.698 22.69 43.854 50.704 38.628 47.295 36.768 42.697 50.438 42.942 63.241 56.455 58.559 63.812 60.522 72.597 75.548 63.765 24.08 14.243 24.375 27.594 30.496 31.834 19.712 35.163 33.63 45.073 29.326 32.816 49.93 42.844 30.09 56.008 39.826 30.04 26.433 23.065 29.311 43.963 48.465 51.275 50.875 51.636 61.386 76.265 55.014 55.306 25.629 25.467 20.567 24.71 30.554 30.701 30.56375 30.93542 34.32617 43.30622 39.58355 44.16042 39.35371 37.05016 54.88039 51.62502 53.10636 52.96225 43.41001 56.70097 17.72005 11.11627 18.63177 16.83109 35.75112 25.90091 14.02039 16.59174 27.54736 32.08694 21.04757 29.0566 34.77684 31.61148 34.22405 34.11116 33.43223 26.25425 17.95232 27.57069 32.92199 33.16194ADVANCE Intensive Correlated 63.604 77.39 65.727 71.557 85.706 79.682 90.396 84.923 46.773 29.123 42.036 45.233 48.48 46.912 54.141 42.104 45.645 47.722 43.599 56.497 73.958 64.581 77.746 79.571 76.085 81.242 66.837 92.794 48.14 21.125 23.549 25.876 30.896 35.325 25.324 43.994 35.942 50.581 43.533 55.527 42.482 44.373 39.301 47.233 45.125 38.665 28.621 27.923 30.982 37.388 66.911 52.564 62.917 49.007 53.792 58.406 48.753 60.992 39.889 33.276 20.833 42.825 42.574 34.986 38.71877 37.48714 43.40671 49.50036 23 35.35534 50.29484 40.7466 51.31833 57 55.73919 59.34163 47.48383 45.12997 18.73881 12.32303 20.36453 37.70184 33.91376 26.88069 13.83577 17.58652 28.89884 43.73622 25.2728 24.35452 45.49254 36.89173 36.81421 36.67619 40.50749 28.95563 34.34489 17.70391 29.99762 29.19393ADVANCE Asia Standard Correlated 90.327 88.441 95.526 107.34 98.072 84.478 89.293 96.987 20.876 25.577 35.864 37.924 33.974 68.468 54.054 42.926 48.931 53.896 37.17 62.159 64.347 63.519 84.239 73.479 81.799 86.272 89.868 84.779 33.719 12.704 7.5631 19.975 25.04 21.886 40.085 40.482 47.108 37.36 24.339 29.189 32.444 23.524 31.837 47.94 24.323 16.625 11.278 6.7676 13.491 5.8652 56.461 65.646 64.96 76.318 72.007 85.033 71.903 59.79 20.469 15.944 18.52 22.865 26.918 48.479 47.78284 43.97044 41.59567 43.49713 50.63003 41.833 45.6377 55.16521 59.82642 50.87829 49.683 56.79084 52.93014 63.71499 9.143304 11.89117 8.342661 11.04536 4.939636 37.44863 30.74411 30.47294 36.94049 21.76695 26.64958 31.2666 21.2132 25.44799 21.84949 34.54562 18.05547 12.77498 13.98571 11.89117 6.723095 10.13903ADVANCE Asia Intensive Correlated 111.28 81.794 83.132 98.4 92.52 90.082 96.726 95.211 23.074 32.775 33.326 32.833 35.592 50.06 54.107 52.6 64.946 51.297 57.976 53.256 77.527 66.934 50.418 66.569 78.483 91.78 60.594 84.704 25.597 22.93 18.963 17.539 36.058 42.818 33.199 40.603 38.181 49.703 38.846 36.837 36.775 34.17 35.066 45.991 25.231 14.22 10.139 7.2388 28.865 27.637 63.74 56.53 62.319 68.79 55.667 58.619 59.484 72.96 36.008 26.092 25.788 28.545 32.119 58.643 47.69486 38.23349 44.85309 39.52468 44.04316 54.90902 65.96666 53.20338 60.29594 60.67949 53.34604 54.56922 47.02765 46.8615 6.033241 14.87279 12.22293 11.01817 20.61068 25.48725 24.82338 26.49906 22.07261 22.71563 23.09978 22.56546 28.16381 21.85864 21.61018 18.85736 22.88668 17.21627 19.19896 7.823043 21.3682 13.53514ADVANCE EME Standard Correlated 82.684 93.358 82.888 64.034 115.41 91.899 85.303 96.922 62.556 63.337 62.14 50.886 63.114 70.355 67.155 66.854 41.26 67.325 68.5 74.154 80.082 78.238 90.437 97.536 103.6 82.158 83.518 97.182 47.588 34.598 43.499 53.303 54.56 44.993 44.497 36.97 54.697 44.808 51.164 44.141 70.437 59.968 74.359 55.007 63.307 56.379 31.016 30.578 47.074 47.745 81.358 56.879 70.427 57.543 83.223 74.377 67.226 62.806 59.511 50.281 47.793 63.503 62.492 55.685 46.52741 42.48058 39.00256 68.7968 59.88656 66.3988 63.44289 68.29788 56.22277 52.63459 75.18776 65.56066 66.36415 69.14767 42.88823 38.8973 46.38965 67.20417 43.89533 32.02187 32.10607 27.81367 39.94496 55.73688 39.8748 50.018 55.44186 59.72604 46.70546 61.73168 49.3518 46.54031 30.28861 39.1561 39.91491 53.6973ADVANCE EME Intensive Correlated 69.03 102.48 78.579 86.909 92.864 91.993 88.88 95.439 71.402 72.507 57.002 63.691 72.985 72.191 72.523 64.645 74.309 84.092 62.887 91.62 95.572 84.8 105.72 95.571 83.046 82.689 94.421 99.477 42.596 51.231 49.002 58.677 42.433 43.25 37.963 45.609 59.245 52.604 48.943 57.435 75.125 60.731 64.365 71.372 67.655 47.64 45.701 47.233 50.874 56.838 56.241 65.08 55.6 72.58 60.481 62.153 41.241 67.304 66.346 57.338 57.763 61.272 71.162 65.955 37.72797 82.26664 42.43112 64.73175 64.3506 56.81197 65.54083 81.38182 56.03749 71.49406 65.62164 75.50629 71.99861 83.23941 38.55905 55.69919 33.68679 34.59191 44.47696 40.53147 25.23886 25.05195 48.94691 34.31326 30.17284 37.34434 70.17122 52.93581 65.00769 70.22535 58.28207 40.09489 44.24251 39.88734 52.29914 57.92754ADVANCE Eastern Europe Standard Correlated 85.726 90.926 79.317 82.884 91.539 98.558 88.135 87.519 69.52 53.833 42.055 52.347 61.465 51.43 39.243 37.35 36.924 46.161 55.163 53.006 66.863 69.059 59.738 81.406 81.632 65.933 66.597 89.076 34.788 21.772 20.616 39.138 40.494 37.855 18.968 24.429 39.299 47.722 31.818 26.721 71.28 47.802 45.957 56.187 53.213 43.021 27.434 31.138 38.887 34.658 61.221 44.75 68.606 67.206 79.159 74.675 66.378 81.505 42.697 24.306 39.669 43.033 53.081 53.072 37.73857 35.98611 38.98974 47.4173 35.98889 39.90238 59.654 53.39288 64.3133 62.89674 72.27724 68.80552 48.70113 68.68479 18.27019 21.29319 13.01538 25.88049 29.66142 20.24846 12.17374 18.25377 36.50479 29.41088 15.8619 42.23979 39.47911 39.09476 46.05866 57.26605 27.5971 33.34367 25.37321 24.78306 35.01143 37.66431ADVANCE Eastern Europe Intensive Correlated 83.908 77.843 91.647 85.872 95.874 91.337 79.791 91.411 63.325 53.158 50.776 57.039 77.057 59.377 52.553 52.169 39.558 68.145 60.985 60.559 85.61 59.319 52.494 51.433 82.071 80.011 68.558 78.427 39.764 29.329 53.584 33.124 47.445 26.495 22.082 38.275 45.288 40.388 29.003 25.683 72.886 63.178 67.574 59.193 62.605 41.792 30.345 29.903 47.493 36.829 59.291 44.562 38.387 45.115 66.243 73.346 58.559 68.901 47.047 41.974 34.214 38.518 39.487 36.409 46.8807 32.08738 32.80854 48.21411 37.97368 52.07111 51.06662 53.30103 58.60887 54.10545 60.26608 51.34783 52.87911 59.18953 28.56921 14.49828 8.843076 41.83061 31.49921 34.68141 14.99333 16.72722 34.45287 34.34822 15.99375 38.64971 57.40906 45.24157 30.49918 55.51576 38.41354 36 10.45945 21.52673 32.96058 41.28196ADVANCE Full Correlated 92.386 85.034 103.18 75.538 95.827 87.727 88.481 103.43 65.245 55.95 50.105 59.896 73.478 77.104 67.396 59.363 63.477 79.917 74.954 71.59 76.548 77.712 71.564 81.305 87.115 96.398 79.019 84.847 52.458 52.832 51.301 57.675 46.133 52.974 36.36 45.514 56.873 66.063 44.287 53.806 61.125 59.341 53.307 82.989 50.416 41.539 34.112 39.472 43.143 49.611 68.712 68.408 72.461 69.157 80.644 86.017 70.277 85.042 60.379 58.164 63.114 60.335 79.093 57.324 50.84648 64.36461 62.7542 56.84764 62.09166 70.2187 83.63505 68.07733 61.23796 63.8465 77.52023 69.75022 65.41476 79.85943 49.47228 28.04694 29.74277 43.49959 45.49018 34.07649 29.80754 27.59506 45.39116 45.92305 37.69515 47.57026 41.47718 50.78885 57.42149 69.29199 58.61813 38.76205 42.2129 30.02956 49.67972 48.77136ACCORD BP Standard Therapy Correlated 74.296 71.869 65.973 63.429 80.292 89.338 70.57 87.007 53.858 65.235 52.059 45.972 69.432 58.729 62.792 71.287 64.566 75.406 55.046 71.671 73.541 67.939 66.991 78.316 91.187 94.901 59.389 89.569 47.55 52.113 45.006 48.552 66.139 55.164 42.295 51.129 58.203 75.463 47.601 57.716 52.944 61.302 57.254 61.572 57.425 48.724 44.751 44.065 58.925 55.671 63.237 68.045 71.195 69.435 71.032 84.317 60.537 73.723 60.656 59.548 53.202 64.226 63.29 70.531 72.52215 58.54797 67.82487 86.51173 68.07878 73.72404 62.27132 67.84098 68.38756 54.65185 69.02843 78.30387 59.29385 78.6532 46.05515 47.626 39.86562 47.73633 52.00224 46.49896 44.91775 41.23435 56.20179 61.85257 55.58498 47.44403 54.98303 62.10443 51.06118 62.21982 55.23042 42.21571 50.99447 47.47472 56.70182 55.98693ACCORD BP Intensive Therapy Correlated 82.016 73.423 86.957 73.702 73.788 90.6 81.732 86.871 58.372 51.955 72.398 44.083 65.846 60.977 58.823 71.794 55.967 57.887 75.698 68.857 79.073 63.884 71.029 60.004 77.79 86.883 66.565 70.092 37.939 38.5 44.563 61.575 64.641 54.034 40.244 43.529 53.082 68.944 40.044 52.274 56.97 56.945 48.933 78.007 51.509 56.919 45.345 44.381 64.442 53.258 69.006 58.119 65.735 50.369 77.335 68.828 60.999 70.847 46.018 44.091 59.855 38.869 67.304 58.264 53.9951 63.04109 51.1597 66.16038 50.41728 63.6746 51.07424 44.62567 57.46056 47.82925 50.54818 56.73 55.85227 63.42404 29.90023 38.28347 40.45682 46.05863 55.8218 44.67576 41.06567 44.31425 53.82613 56.86185 47.9141 56.48717 41.47728 41.68698 56.41195 61.946 44.60033 38.17652 40.33538 38.86472 57.40778 51.68197ACCORD BP Full Correlated 78.132 75.553 79.028 88.19 91.855 90.717 71.135 80.905 67.474 64.444 72.621 51.74 67.539 71.765 70.195 66.14 70.295 79.638 68.845 84.386 66.329 73.181 74.43 75.348 77.927 82.63 78.441 87.763 49.177 43.947 43.518 56.657 72.515 46.496 47.307 53.258 53.389 72.708 53.518 60.882 62.042 75.191 56.039 71.1 66.613 56.203 55.179 39.466 62.037 53.093 75.971 60.862 68.863 64.464 79.333 77.922 63.311 90.403 52.764 52.874 60.592 49.087 67.517 60.228 60.49518 58.10243 58.14058 74.35935 57.94247 67.32869 59.05167 53.59443 63.66799 48.28172 67.23709 61.74021 55.82206 64.3326 45.89693 40.29929 42.71524 53.45227 64.16985 44.45149 44.23524 49.14979 52.59231 61.45166 50.89269 53.96361 41.20191 44.92455 51.03905 61.96513 45.58232 39.89546 35.40417 39.34315 60.36107 52.93222KP 20-34 Correlated 23.184 18.344 26.8 16.837 20.694 20.899 19.164 22.428 10.464 10.747 13.519 9.7211 13.086 15.636 18.655 17.664 12.787 15.058 18.875 18.398 13.435 17.428 22.55 22.051 12.52 25.353 17.248 15.78 9.6047 14.133 15.748 14.204 11.811 14.195 15.922 17.226 18.055 14.925 16.681 17.015 8.6168 14.722 12.894 11.937 13.638 7.7782 14.265 14.68 13.847 11.99 14.414 17.909 20.748 21.926 22.897 14.748 22.951 18.007 11.292 11.554 11.587 9.7211 11.683 9.6825 14.61164 25.70992 14.25658 14.66288 19.44865 17.0147 7.141428 15.6365 19.9374 14.08013 20.8866 22.01136 14.5688 14.1598 7.599342 13.64734 9.912114 9.124144 14.3788 12.30853 15.32155 20.59733 18.98684 18.53375 20.5061 16.02342 8.616844 17.53568 9.565563 13.22876 14.66288 9.407444 13.7659 12.35921 18.04162 16.68083KP 35-50 Correlated 51.877 52.607 50.185 51.834 61.229 46.43 43.669 56.866 34.253 46.462 34.921 38.383 34.486 26.182 41.812 39.045 29.176 36.763 25.933 35.795 54.461 60.791 67.017 53.446 66.708 67.22 57.953 54.587 30.802 41.623 24.865 32.5 38.594 29.39 28.745 28.125 39.462 40.509 49.852 50.666 35.857 39.781 37.616 41.373 42.656 29.373 33.027 39.44 41.788 36.844 46.508 56.73 46.257 46.872 51.425 51.308 58.34 50.326 30.012 45.244 38.881 38.144 46.165 38.442 41.6143 38.2034 35.83643 48.01302 39.19503 45.50824 60.38833 68.4087 64.53875 50.92887 61.23316 51.25427 50.12484 58.51923 35.75612 31.99609 40.53702 46.03531 44.18993 30.6635 25.59785 24.995 34.17967 26.67864 38.11168 37.3497 32.01562 38.91979 27.40894 36.72193 34.24909 30.84639 37.61981 31.85122 34.42383 37.61316KP 50-65 Correlated 77.822 82.506 89.987 82.272 100.3 97.341 90.497 103.5 60.986 57.734 62.552 62.231 81.383 52.49 62.51 71.084 55.794 78.789 50.087 81.783 94.888 104.87 104.78 99.027 103.03 106.32 96.339 104.47 51.505 50.671 52.564 64.659 72.232 45.346 58.922 51.578 60.659 55.505 60.908 73.121 54.208 76.776 58.792 73.372 60.758 52.086 46.637 58.724 73.14 60.087 70.523 77.721 93.747 75.773 104.99 97.241 89.121 94.012 67.615 74.271 64.121 70.244 79.632 61.553 63.90031 56.59064 70.41129 65.69817 64.02148 75.4586 96.38594 96.74838 96.92136 94.39942 104.7306 104.324 103.2945 104.0216 37.67957 57.97198 55.02499 62.0665 65.92609 38.1248 69.87489 49.97499 62.19727 61.09214 44.14465 66.22877 66.23254 71.07215 72.34984 83.49551 65.28017 46.89616 49.64121 50.9436 60.08328 47.31807KP 65-75 Correlated 123.21 108.21 121.29 115.23 124.15 121.38 116.15 135.03 83.46 87.103 93.714 107.39 117.32 115.03 108.78 116.12 123.64 121.52 111.64 130.41 120.34 94.128 92.933 97.494 103.4 125.86 94.177 111.56 69.471 81.017 78.054 78.838 84.592 85.894 69.266 87.049 103.83 103.04 91.801 82.485 110.65 107.35 114.93 111.63 92.915 63.411 80.785 97.779 104.73 96.893 120.6 104.59 100.06 131.69 118.5 117.63 110.79 133.97 102.99 100.75 110.39 101.22 128.98 111.42 95.31264 117.6977 118.311 125.862 120.0927 131.5076 87.05889 89.57399 104.0973 110.8388 122.9837 116.6244 104.8642 120.1863 75.28944 72.59132 79.15491 91.5833 104.3528 83.68244 80.88881 72.83715 104.2809 100.307 81.39564 94.63086 99.66695 99.95749 106.9871 132.632 102.5171 96.20551 80.07809 82.49394 98.27004 93.63493KP 75+ Correlated 166.68 149.46 142.69 173.54 165.56 167.94 144.18 143.89 157.74 153.89 133.28 170.43 145.94 177.97 147.52 163.05 190.05 150.45 134.78 180.34 122.6 89.72 100.17 138.44 115.63 125.13 95.292 121.68 143.68 121.36 146.51 135.01 137.55 155.19 136.99 149.19 152.21 159.18 127.52 149.51 163.58 137.73 164.35 166.42 163.6 140.78 119.64 139.03 150.6 139.4 169.44 148.61 155.75 185.27 158.23 158.13 130.71 141.27 167.86 119.99 128.33 154.6 160.29 180.77 145.2265 162.3499 188.8333 171.1184 131.9782 165.3133 127.1908 106.8352 99.47613 145.4381 129.244 118.1196 105.513 127.3283 148.2068 115.8555 144.6807 127.6215 146.9132 156.305 136.9033 167.4074 143.2925 152.6663 128.6954 143.8011 178.6246 145.4089 180.5443 173.8606 159.1674 148.0616 136.6885 144.8206 149.6713 137.0711KP Total Correlated 146.38 134.33 145.46 129.98 123.38 137.77 137.69 144.67 87.163 79.817 95.51 90.373 104.39 110.59 95.926 108.9 82.699 112.81 96.354 120.08 120.86 110.73 113.36 99.172 98.165 120.49 95.3 120.91 85.889 76.413 73.454 80.119 100.39 93.187 84.6 89.358 90.437 84.098 70.382 85.222 95.882 105.33 99.61 115.72 94.927 69.716 72.526 76.286 89.081 93.513 115.28 127.26 137.7 136.82 148.67 160.32 139.14 123.9 98.881 80.023 103.43 99.551 102.44 118.78 105.2121 103.6874 101.3986 109.4736 114.7082 107.3657 114.0517 95.07103 86.53523 108.3453 115.23 107.5457 93.80628 103.2313 84.84961 75.65107 68.52665 93.45176 88.62128 100.9992 80.40919 72.75474 103.091 102.7207 80.60832 82.77928 92.60953 91.62098 86.7396 111.5541 87.00623 80.39023 71.23042 78.5985 111.8787 84.55756NDR 20-34 Correlated 26.249 20.591 20.616 19.723 20.616 23.505 16.688 28.302 13.601 19.925 19.609 15.89 18.788 10 14.142 15.508 18.868 13.342 20.616 16.14 26.315 24.352 37.443 28.018 20.797 22.902 22.192 26.618 15.62 18.358 20.125 19.416 28.018 10 19.723 16.155 19.039 13.601 14.983 14.56 19.105 20.261 23.717 25 22.192 19.105 16.808 21.691 27.722 25.06 17.029 27.83 24.87 25.544 23.033 18.868 18.507 18.561 16.401 20.125 18.868 19.912 21.633 11.336 13.92839 13.92839 7.615773 16.14001 15.70032 14.31782 26.95366 27.10166 18.56071 26.31539 26.23928 21.96588 25.94224 25.34758 27.6134 19.72308 21.09502 20.0125 20.80865 21.26029 18.43909 17.49286 12.74755 17.02939 17.72005 16.76305 21.26029 20.61553 18.56071 27.01851 22.7706 27.58623 19.55761 31.40064 21.09502 25.387NDR 35-50 Correlated 32.83 35.037 34.692 25.059 30.708 32.168 34.411 32.224 31.688 28.222 27.166 23.02 32.516 15.287 18.774 19.142 18.374 23.746 18.66 20.272 43.572 58.257 48.992 40.116 44.627 45.628 47.019 47.68 25.086 21.73 21.946 24.145 26.907 15.537 15.146 19.024 18.281 14.819 19.715 18.66 37.803 24.453 25.823 30.112 33.749 33.713 21.101 24.695 30.987 27.341 26.466 32.003 12.243 35.12 31.367 16.739 27.757 31.561 21.532 28.222 26.243 30.673 26.879 10.927 19.72403 18.28645 25.52676 24.65553 12.76853 23.739 47.75744 44.30636 45.38942 44.69083 44.36115 46.9177 37.38 57.70979 25.66073 21.78069 31.65401 31.61669 26.50961 10.3596 19.72403 23.5123 17.68472 19.30687 29.77363 21.26622 37.07785 26.65067 26.54329 27.44684 40.08716 25.82306 31.48999 25.39211 23.0009 29.68237NDR 50-65 Correlated 49.132 56.155 44.513 56.598 48.87 63.415 51.533 54.05 42.757 41.295 52.902 42.933 55.431 39.688 26.087 29.252 35.796 41.891 49.204 44.256 63.994 56.435 62.784 68.289 66.774 71.383 62.256 82.755 29.899 33.561 24.373 45.235 34.039 28.293 25.075 24.432 49.472 26.534 25.847 39.119 47.011 47.772 45.387 56.145 58.791 29.586 34.39 27.966 32.74 37.43 61.874 60.316 40.219 62.145 70.948 58.128 60.286 74.258 51.273 52.217 45.387 46.587 45.628 36.606 31.20048 32.02402 33.88543 50.58267 43.47098 40.72407 75.35178 72.13663 62.39361 65.81047 81.64838 65.60587 85.45119 69.42975 39.69506 40.21888 35.77432 36.46195 41.37035 22.58641 18.57014 27.96594 31.54771 35.45231 37.80336 37.03482 43.49462 56.21969 44.23395 46.09809 55.48263 43.58337 30.85719 48.28994 34.54652 40.76202NDR 65-75 Correlated 97.757 81.827 94.204 96.889 100.33 91.862 87.888 92.127 62.087 77.605 65.503 61.096 51.495 63.267 53.245 49.883 61.754 52.651 56.219 68.839 65.514 75.21 62.425 73.843 70.156 76.29 59.036 81.428 40.725 41.857 28.16 51.342 38.803 45.119 24.187 38.325 43.154 40.552 37.036 56.644 64.226 60.446 66.345 61.872 63.168 50.906 39.095 43.41 44.129 53.151 88.339 86.475 90.075 102.38 96.077 96.524 87.827 100.12 65.357 59.526 54.344 57.851 63.081 54.379 59.6309 53.40206 74.39136 56.2367 55.37149 58.47921 64.66605 83.58465 65.25101 65.93018 66.87941 78.35349 63.16822 68.3025 41.74729 46.10137 36.1808 49.79739 49.15024 47.95014 32.66613 28.98783 39.14103 49.34063 31.92839 43.71277 79.54905 77.26183 69.25234 62.10129 67.40835 50.21141 44.70099 44.54905 45.75542 51.17828NDR 75+ Correlated 89.257 105.56 98.317 97.194 97.367 95.735 113.48 105.36 70.717 54.476 53.406 56.063 46.198 108.29 62.675 63.041 73.911 60.096 72.99 75.673 75.694 40.192 25.634 37.108 27.407 42.953 33.633 46.493 74.145 29.897 30.776 32.098 52.656 75.738 42.142 42.117 43.401 49.43 43.524 48.435 100.94 70.096 69.087 70.341 68.254 72.896 40.065 34.654 45.768 31.26 103.42 114.26 103.1 96.038 105.46 88.279 106.31 97.464 65.613 63.13 49.239 58.398 58.852 78.818 73.47762 81.8822 58.16476 71.74029 79.31383 71.01226 64.5972 53.06071 37.80275 35.4047 30.70229 38.68214 37.68143 48.0107 75.92238 22.26827 44.92602 33.66645 36.08918 74.82655 40.49127 62.91005 45.86712 45.86712 44.35119 38.76189 84.41613 68.26504 67.8415 67.70814 66.26611 75.1667 32.81376 57.19868 51.25671 38.35364NDR Total Correlated 95.503 86.129 88.986 97.033 101.03 105.78 89.436 109.22 59.472 75.724 48.489 54.319 65.187 64.664 69.181 69.283 51.839 61.239 56.097 71.476 87.564 52.359 70.972 73.628 69.33 72.603 73.35 69.587 54.091 31.001 46.425 42.217 41.651 44.176 42.424 39.601 50.117 45.751 38.335 51.258 69.085 76.313 62.325 63.901 64.919 38.87 53.196 34.254 51.31 49.373 95.831 95.361 98.892 102.67 113.23 114.34 86.766 102.67 66.106 48.82 52.299 57.019 54.642 63.976 56.92372 57.23412 68.86218 64.14354 58.59646 71.48034 78.45936 71.34014 74.55945 58.16603 74.17805 65.72447 67.31744 75.59318 53.75821 39.73529 32.8404 50.12076 41.36338 57.61716 50.07749 39.58331 51.25682 54.49055 52.2954 50.64016 52.90685 75.51251 67.96416 68.14079 64.91941 42.1508 49.5799 49.5799 45.67361 51.53363AHEAD Control Correlated 81.756 72.35 70.084 76.008 80.386 76.181 66.125 68.316 67.459 70.146 75.585 78.043 84.94 85.247 78.214 99.269 75.834 93.595 72.16 90.902 87.741 89.183 92.186 96.652 102.19 104.02 72.506 106.43 54.997 60.962 56.477 70.616 59.041 57.087 67.676 72.353 81.125 73.126 60.117 72.577 80.562 81.705 79.503 91.014 66.616 60.916 63.019 74.855 58.915 62.877 50.377 66.484 69.597 55.963 71.752 65.991 54.324 59.149 59.293 74.944 72.268 80.703 74.138 78.677 86.34861 81.02097 88.56813 81.10023 86.69793 83.04284 79.04566 66.40927 82.51667 80.67526 92.73681 96.65808 90.14785 86.22908 48.21716 52.41076 59.58864 65.93725 61.0871 54.14814 57.71006 65.42981 69.24639 74.37791 58.39436 76.77518 59.46336 73.56583 71.98423 80.65294 77.27151 53.69545 52.06021 46.55756 59.79139 64.2663AHEAD Intervention Correlated 58.952 61.126 70.534 66.24 74.949 83.084 77.431 73.875 68.407 63.309 51.151 73.768 87.17 92.025 70.642 83.709 94.905 73.355 76.636 82.665 95.503 96.717 94.075 85.606 112.24 107.19 83.364 90.164 58.09 62.159 57.314 54.887 65.073 58.549 67.292 70.301 64.343 86.904 65.151 66.883 64.256 66.106 80.082 83.66 63.892 66.304 60.015 56.177 68.5 64.942 56.68 61.401 65.45 63.067 70.228 75.59 67.622 65.617 46.067 55.976 62.232 80.309 60.8 65.16 69.16074 63.23811 84.38677 71.75974 71.46705 72.96682 76.85434 67.8844 84.33021 88.72437 82.58245 97.863 78.66008 84.16483 52.85208 56.30461 50.96493 64.53192 59.01392 46.3583 58.25807 51.12826 70.37357 75.1436 60.52434 61.67986 76.03123 69.92481 78.51487 70.4507 63.89326 50.0806 55.02804 60.91714 67.60156 65.91877AHEAD Full Correlated 63.695 66.499 73.498 78.252 64.832 78.205 74.073 87.681 67.804 71.303 70.443 73.294 85.083 74.099 76.494 71.775 89.498 91.93 69.06 90.223 82.365 82.292 71.927 105.02 116.44 106.63 92.64 94.813 46.329 51.32 65.214 65.876 75.584 67.425 69.013 73.762 69.974 68.611 58.458 75.488 70.438 79.521 84.291 74.652 75.666 54.594 53.211 59.62 65.599 75.112 53.693 56.184 56.258 69.186 67.363 77.429 67.834 67.532 70.997 55.639 69.539 65.967 70.9 74.667 77.32356 83.36665 88.19548 82.85811 81.44887 77.19396 57.24897 82.29208 90.21114 96.72228 84.9623 85.42324 91.02974 74.15295 45.30319 55.1137 56.66488 52.28777 62.84918 45.16567 46.78993 72.99388 72.86382 67.947 54.50716 71.32261 74.56113 73.66356 82.17 85.66469 79.64009 50.31529 49.11199 65.63619 61.00061 62.98918ADDITION Routine Correlated 59.802 56.732 61.561 69.423 66.779 72.317 63.663 69.762 58.267 56.292 52.19 47.183 54.208 38.02 46.054 32.791 53.033 52.598 41.104 58.6 79.205 88.395 99.736 95.159 87.483 95.514 95.914 79.481 32.749 32.307 50.312 50.985 38.92 29.845 44.682 26.206 40.896 28.805 30.492 47.334 54.658 58.185 69.432 72.026 66.549 42.512 44.396 45.089 54.53 49.855 37.128 42.773 29.979 29.351 57.563 50.698 33.653 54.5 37.98 39.62 41.572 53.174 40.15 25.99 33.8969 23.44142 40.23059 37.53998 42.02678 47.54209 60.9713 50.30408 63.30087 55.88604 61.86477 64.81898 66.04733 56.3671 30.60229 21.59861 22.10204 29.74054 26.54713 26.16295 17.53568 26.8235 34.64823 24.91987 26.02883 27.46361 45.89662 37.23909 39.51582 48.33477 40.43513 25.10976 29.20188 30.54096 39.2269 37.15508ADDITION Intensive Correlated 66.5 72.244 58.596 63.951 57.4 74.113 71.174 61.129 57.308 57.983 60.289 47.286 61.096 52.034 50.433 51.909 64.323 63.646 52.309 62.646 78.653 89.15 92.519 81.482 99.746 91.88 100.69 101.51 35.868 47.17 41.632 46.371 63.775 44.404 32.879 31.93 56.734 48.094 36.623 49.026 55.206 63.457 65.297 64.23 63.963 52.043 44.73 48.518 44.925 66.577 43.629 37.987 34.275 34.868 58.794 39.326 43.284 49.596 36.544 41.848 44.065 44.744 46.621 31.472 30.52048 35.75961 42.13965 50.13482 32.84814 48.65182 56.87047 64.27675 66.38712 80.68922 60.1602 63.02777 52.82992 67.81961 35.2881 25.40177 26.20115 32.7185 41.27348 29.33428 39.82462 22.42209 32.04294 30.78149 25.31304 28.78368 53.64466 51.16151 45.16082 60.03124 50.09741 34.99643 27.90161 28.09804 40.45368 46.68779ADDITION Full Correlated 62.438 61.076 66.082 63.124 58.788 73.898 72.863 70.285 56.349 58.349 49.258 59.934 69.784 43.039 41.627 40.186 55.826 61.428 57.607 61.314 83.183 81.672 90.64 82.471 86.522 87.719 91.152 90.395 40.157 41.368 41.58 53.864 51.141 25.61 47.293 37.9 37.411 41.328 40.141 38.957 58.921 70.159 59.636 67.078 72.464 40.072 50.53 49.317 43.442 69.144 18.592 38.827 33.136 39.034 43.309 46.466 39.412 51.295 40.163 34.245 40.044 48.139 47.134 25.157 41.39042 34.89201 27.71402 34.33489 31.85641 46.41751 56.17868 54.76712 66.77478 68.91273 65.32207 45.63318 60.52524 59.31724 20.66338 40.35355 34.76198 41.41723 39.09598 26.07513 28.53525 19.10739 37.49474 36.12187 27.18159 42.24828 43.88415 47.09286 45.43896 48.97049 46.88119 28.59037 42.32757 25.46496 54.26152 35.3011

UKPDS33 Conventional 22.682 33.113 31.04 21.467 58.797 38.473 49.675 72.61 46.327 55.362 61.86 51.552 52.244 32.016 43.968 42.604 47.724 64.85 47.309 61.787 9.7618 40.66 29.562 30.556 47.76 45.486 47.546 60.719 27.017 37.616 31.844 51.351 51.828 15.865 28.79 29.999 56.376 48.941 49.987 53.421 59.375 55.497 70.846 67.805 66.765 42.636 47.266 43.311 51.41 77.712 16.362 33.556 29.202 35.924 56.793 52.785 47.507 69.458 43.677 62.196 53.322 49.326 60.571 29.136 39.75568 33.98455 47.80412 55.81559 55.99189 78.30599 14.0096 34.19175 27.94858 37.8329 46.23177 43.65464 51.02163 61.35953 22.33977 38.15995 34.80526 57.9613 44.46611 20.51818 40.04357 36.33323 54.51511 50.50104 47.94879 57.23485 53.81419 60.50669 63.14598 72.30952 65.76327 29.49698 32.49851 42.69933 59.34713 71.70911UKPDS33 Intensive 6.3796 31.901 21.355 21.808 44.647 39.198 42.409 62.237 49.715 64.244 45.998 47.637 78.034 35.72 48.342 37.518 50.442 69.557 51.078 70.74 13.226 29.297 28.832 28.378 48.84 42.832 34.163 64.802 39.933 34.48 40.189 65.505 48.064 14.792 38.754 33.475 61.376 51.108 52.477 70.215 58.405 62.246 75.086 72.655 63.546 52.614 48.301 61.614 62.136 68.209 17.232 32.496 29.855 24.163 53.94 42.385 36.971 69.812 50.671 57.545 42.312 61.81 58.501 41.066 47.9072 39.87996 57.97196 74.82128 55.83234 68.60185 12.09508 33.70208 26.11277 25.80335 58.02875 41.98888 43.66763 60.7739 31.99438 43.3154 42.22283 60.96123 49.26492 17.46408 43.71416 30.87702 66.79641 49.21984 46.54577 61.1083 63.17527 67.2213 67.16097 84.9948 71.37707 55.89949 48.5736 55.82556 63.72802 80.59222UKPDS33 Full 14.099 29.692 39.376 28.19 46.482 43.348 45.568 62.26 43.566 59.194 55.528 54.357 59.978 33.304 55.717 35.968 44.782 62.873 54.881 71.634 13.517 25.037 32.966 21.241 49.896 38.614 39.796 65.711 32.339 34.154 35.974 62.306 48.997 24.989 34.989 19.835 57.014 50.548 40.744 62.186 49.85 60.521 64.334 74.852 79.501 42.618 44.564 39.652 49.715 66.595 11.117 22.683 31.788 25.962 52.321 42.66 40.038 66.867 48.007 56.108 50.548 47.068 67.396 33.428 42.00793 56.74762 41.93285 61.36435 48.32392 77.76668 12.31117 32.33717 29.9773 28.03243 37.16035 34.45346 36.66629 59.17629 31.81025 34.97856 30.79973 62.94258 47.14706 21.39873 32.26441 22.79815 50.94836 47.371 47.54967 64.92126 54.18096 63.45564 59.04307 62.99639 71.69251 44.45669 45.91503 43.39417 57.75868 74.62617ASPEN All Placebo 19.887 14.874 15.819 7.9687 19.558 15.827 10.428 15.379 28.182 21.84 29.176 32.152 30.59 14.637 25.105 18.426 26.865 30.166 23.479 27.12 11.023 15.322 10.32 12.329 19.098 23.701 17.628 26.106 22.721 12.309 11.758 17.313 15.338 13.105 21.92 11.225 21.622 24.223 20.736 24.824 26.763 25.656 28.762 31.253 34.337 12.052 21.372 12.981 19.455 29.266 16.591 11.906 11.269 12.298 11.8 19.085 8.6891 27.902 24.094 21.249 29.013 30.68 29.975 25.224 25.5 31.28098 20.68212 32.76431 20.70024 20.46949 10.54751 14.29161 19.9875 15.69235 20.5061 21.24265 22.52776 18.70829 12.75735 21.19552 12.5499 27.16155 31.68201 15.34601 19.67867 21.01785 18.41874 18.19341 29.52118 25.26361 23.2056 32.65348 32.3651 32.77194 33.84524 23.16247 13.81123 21.30141 22.88012 25.89401ASPEN All Atorvastatin 17.27 9.0692 11.158 11.554 18.688 23.764 12.59 24.875 30.533 30.863 28.421 24.474 31.82 28.386 32.932 30.257 33.083 44.716 35.76 34.663 8.5732 13.574 16.852 15.149 16.462 20.062 14.509 23.948 15.676 23.383 22.028 26.5 28.271 19.748 19.729 21.806 28.745 28.403 19.634 30.426 35.475 42.559 33.068 35.798 38.623 22.181 26.889 28.262 31.82 37.733 9.7211 11.533 16.778 11.937 26.655 20.946 17.393 21.972 32.917 31.068 25.485 23.399 33.731 36.445 31.12876 21.9488 31.38869 32.91656 38.24918 24.60691 15.02498 19.352 13.55544 11.97915 15.3948 19.9374 15.42725 23.58495 16.95582 17.97915 12.93252 16.36307 29.40663 21.04163 19.60867 19.30673 25.03498 25.99519 18.20714 20.65793 24.58658 30.95561 35.55981 30.53277 29.47032 19.30673 25.015 22.28789 20.99405 29.30444ASPEN Primary Placebo 17.103 18.822 12.278 17.342 15.524 14.335 15.882 20.694 23.838 37.209 32.121 35.274 37.33 34.172 32.508 24.377 24.357 37.047 33.034 44.051 13.509 13.388 7.1414 18.405 17.176 16.83 12.679 27.051 30.174 20.982 17.93 37.769 24.51 20.767 28.258 17.197 26.211 20.31 19.577 26.163 33.155 33.027 42.471 43.049 35.648 21.131 28.561 21.96 37.034 39.872 13.229 8.1086 6.8374 12.339 13.36 13.134 14.714 20.205 32.757 28.684 33.649 38.798 35.728 30.7 20.67607 32.34579 23.04344 39.70831 24.46937 38.17394 11.45644 5.567764 9.137833 11.78983 18.77498 13.38843 11.69402 25.64664 30.42203 20.90454 21.36001 30.3521 24.80423 22.99456 24.11431 22.41651 28.74891 19.42936 20.2052 37.21223 38.72015 37 33.94849 43.11032 44.77723 26.88866 21.41261 26.30114 29.06888 27.43173ASPEN Primary Atorvastatin 11.822 9.6566 10.886 10.062 19.481 17.212 13.229 28.901 30.012 28.165 37.047 33.324 36.51 28.539 29.253 28.08 30.7 28.244 27.704 38.2 6.7639 13.295 11.258 14.16 19.326 18.398 12.629 22.683 24.285 18.908 24.336 27.34 31.583 16.21 24.218 19.157 24.764 20.857 23.843 32.55 34.106 44.187 38.791 42.831 30.033 26.476 31.973 26.819 28.544 35.655 10.84 14.37 13.601 15.411 12.933 16.279 8.0467 18.695 33.782 33.35 23.859 28.009 35.267 22.028 27.38156 31.45234 29.31723 22.78706 30.26549 26.66458 16.07794 14.20387 12.45994 8.860023 15.94522 16.52271 10.24695 26.99074 16.77796 16.46208 18.73499 27.90609 21.1542 16.92631 21.22499 15.54027 26.63175 24.31049 20.04994 20.42058 43.57178 37.66962 34.28557 35.83643 36.18011 19.17681 22.74313 21.58124 33.20015 30.80584ASPEN Secondary Placebo 32.535 39.326 47.112 42.388 36.218 57.406 37.6 39.414 4.5826 10.747 22.125 12.629 38.144 24.156 19.672 25.661 25.005 38.849 20.087 30.216 56.84 50.446 53.308 42.468 46.111 68.326 50.423 49.104 28.5 25.343 22.82 34.85 49.847 6.8739 17.741 14.671 24.485 25.889 11.885 30.875 12.278 19.881 13.528 40.134 14.107 17.875 24.423 28.814 42.787 33.76 40.488 47.231 39.607 36.29 46.96 53.742 32.168 44.679 11.169 16.748 25.681 10.173 43.595 30.307 40.71241 42.12481 17.07337 25.90849 37.98026 43.00872 49.11975 50.08493 49.5757 43.7207 50.38601 53.30572 47.42626 52.6925 24.18677 29.858 27.20754 23.18405 44.07947 13.7659 8.558621 13.55544 27.40894 42.37334 9.460444 29.3428 16.78541 20.13703 13.13393 30.72865 13.2382 8.87412 21.27205 16.41646 40.23991 22.23173ASPEN Secondary Atorvastatin 11.843 19.404 31.056 24.254 32.703 36.232 21.113 35.121 17.125 17.678 33.242 26.735 38.558 44.522 39.727 52.969 52.813 52.17 56.167 48.585 22.864 28.526 30.046 27.527 35.415 40.74 30.125 38.662 14.37 28.836 19.209 35.071 39.147 22.995 18.722 28.289 36.201 51.505 29.542 44.892 26.476 35.475 35.05 49.059 26.632 10.512 30.381 23.141 50.423 39.671 19.17 21.749 27.852 15.898 27.951 48.13 23.543 39.083 11.63 21.668 24.93 22.842 45.577 49.747 45.82848 34.82815 43.77499 47.32336 38.35036 46.21147 31.35283 30.51639 34.83533 36.54449 31.48809 47.34184 32.29164 36.10055 12.14496 23.73289 21.78876 25.27845 42.1693 20.3224 13.68393 26.05283 29.48729 37.65302 35.53519 27.72183 14.46548 20.63977 22.28228 40.06869 28.04461 9.26013 25.8215 16.45448 35.75961 29.31723ASPEN Full 12.674 16.7 15.91 13.514 17.302 18.327 10.326 24.205 14.513 22.133 19.846 22.883 23.977 11.635 23.476 17.331 25.202 26.891 12.047 26.756 16.952 13.652 18.524 11.71 16.397 23.741 18.415 30.771 18.341 9.1036 7.7055 19.452 16.819 9.0898 13.725 13.987 24.751 19.934 19.413 18.204 30.486 24.023 19.884 22.173 24.241 17.752 21.694 28.18 14.744 23.38 18.584 12.425 16.42 12.654 17.759 18.692 20.503 17.317 14.401 15.886 20.937 16.504 18.951 17.78 15.17811 20.25154 19.80215 24.13763 22.84458 22.08789 14.55593 17.49643 21.69965 14.36576 26.40786 22.00852 17.288 27.58849 9.212763 12.61448 6.846532 10.68293 18.82485 15.2848 13.01442 7.424621 22.35229 14.92062 11.66726 20.76957 17.72357 19.52882 25.65395 24.20485 29.34493 15.33379 15.17811 14.00446 22.83364 26.63879ADVANCE Standard 13.974 12.912 8.9123 11.563 21.501 30.019 16.916 19.745 39.708 35.098 40.89 35.927 44.409 38.93 33.586 29.297 41.782 48.631 42.847 67.542 21.037 10.177 12.387 9.4944 25.876 27.384 14.516 22.634 20.213 9.204 17.784 33.422 34.631 13.169 12.335 29.862 42.84 31.296 21.762 38.554 34.988 36.536 41.29 50.78 46.554 14.682 31.099 24.634 28.661 43.62 12.598 13.229 12.218 8.1591 12.801 26.737 10.226 14.462 21.676 24.574 33.901 30.414 41.005 26.801 29.3087 24.43066 30.22771 38.12761 43.41823 35.47031 30.65476 18.59723 16.12009 11.26943 21.37087 22.78784 18.58955 19.2836 15.82945 18.52026 16.73747 17.90052 24.28403 15.82945 18.30301 18.77308 27.59658 18.70447 17.86057 34.62245 19.89616 36.84717 32.39047 37.10988 34.13628 18.44683 12.13025 19.17588 27.67929 29.64312ADVANCE Intensive 17.134 9.7907 14.208 16.941 28.676 34.157 16.013 27.757 32.049 27.506 41.264 32.002 51.571 32.492 45.242 36.909 37.336 62.802 46.074 58.502 14.092 12.541 14.112 9.3808 18.323 27.255 15.575 29.333 21.21 16.466 23.537 34.397 27.798 22.586 24.576 26.67 48.621 39.337 27.928 54.073 38.706 35.962 34.769 50.599 41.732 18.377 27.888 23.67 41.395 35.069 17.304 13.748 13.137 7.7919 21.607 24.113 7.4833 17.948 21.906 23.54 35.141 40.137 40.05 31.362 27.45906 36.04759 33.07783 45.06028 26.4845 44.00325 15.08074 11.24405 13.94889 11.86231 13.89758 13.43769 14.62386 20.0713 9.486833 15.39016 19.38704 30.11881 31.35966 19.48992 10.92834 16.75027 26.15339 29.04184 17.05453 23.26248 33.8104 40.04997 33.54315 41.67905 37.72078 12.91179 22.27747 15.33437 31.96203 28.79484ADVANCE Asia Standard 26.226 20.586 8.8657 11.55 16.751 19.708 15.356 17.692 19.935 19.391 27.078 16.763 37.752 36.609 39.294 39.133 44.741 42.311 36.442 49.016 25.342 21.401 12.578 19.432 17.193 11.705 22.53 20.174 25.573 21.703 16.168 9.5289 18.847 27.17 22.623 20.169 21.762 30.486 24.323 22.168 26.963 34.957 20.396 26.71 18.687 23.971 13.885 22.154 16.679 15.013 30.043 17.956 20.154 10.844 9.1104 16.407 25.612 11.95 27.593 22.83 23.753 15.186 30.166 34.537 34.81092 34.09105 36.16075 35.64828 33.89985 39.72657 35.03427 23.04344 18.14387 28.56221 16.8226 17.58977 22.54773 14.45683 34.4093 16.88787 15.32971 13.76953 11.98332 28.26659 21.89064 14.19155 17.69746 17.52142 23.02607 29.80268 27.24335 27.0555 23.25081 23.38803 18.95785 24.85961 16.18023 13.54991 15.33623 11.14451ADVANCE Asia Intensive 24.22 15.382 17.012 7.4027 12.231 24.302 15.843 17.788 22.865 19.647 31.119 23.795 35.57 36.973 49.58 34.22 41.204 42.984 45.861 40.549 22.28 14.526 16.236 12.53 12.361 23.401 16.625 11.091 25.698 11.824 16.438 24.896 15.12 24.739 25.326 27.037 31.458 32.628 22.235 32.119 25.652 24.38 28.096 26.956 39.005 18.083 13.483 16.965 18.237 15.659 29.594 15.543 17.748 8.2946 11.67 9.1104 21.109 17.47 25.904 25.365 20.075 27.644 25.338 25.687 29.93326 25.39291 46.80598 28.14249 32.28622 28.62516 31.60696 18.9842 18.47701 12.89961 10.75174 19.54994 24.23634 14.89966 23.2379 15.96246 10.63015 10.0995 10.16858 25.26262 21.0808 19.71801 18.15489 32.54228 21.42429 20.46949 19.59592 22.58761 27.07028 23.2422 18.88915 24.3146 15.47902 17.69181 12.32071 14.58081ADVANCE EME Standard 15.277 25.996 16.882 18.499 42.367 31.142 27.368 41.272 29.203 44.018 55.534 61.869 64.12 40.934 62.098 45.193 54.057 60.655 51.803 67.637 22.909 19.011 18.708 21.513 30.203 25.144 33.398 36.669 23.203 34.464 19.985 52.351 38.158 16.941 35.395 37.076 54.213 45.416 51.387 73.993 52.249 59.736 58.328 61.379 60.6 23.379 41.449 50.082 50.67 51.078 18.989 18.237 15.563 17.035 31.997 33.607 20.761 51.241 31.132 29.688 36.669 42.452 63.927 40.983 42.9907 44.39369 45.51264 49.00612 34.58902 51.0294 22.71563 24.11224 23.3538 20.94755 35.02856 30.19934 23.68122 27.43356 11.54123 24.44995 27.21764 30.02332 38.00526 10 26.8961 39.32429 43.42119 51.14294 40.68906 38.17591 35.19943 35.44573 44.70123 50.22748 51.47232 17.34359 32.02187 27.21029 45.00222 49.21788ADVANCE EME Intensive 8.5206 20.288 31.222 15.113 29.377 46.478 20.025 48.555 54.19 47.278 53.755 44.524 61.644 41.564 43.107 55.941 68.167 66.543 60.806 68.05 11.082 18.916 18.601 15.46 44.353 34.508 17.199 33.064 23.452 34.788 42.821 57.618 60.216 19.468 22.887 40.022 62.779 47.147 49.289 59.765 54.566 72.945 55.411 77.562 63.826 36.932 44.075 43.118 55.236 55.669 19.975 20.376 17.263 12.791 27.839 35.471 28.775 33.991 39.651 41.893 40.733 41.214 54.807 25.76 39.07685 40.78725 39.19694 47.46156 47.59202 51.11556 15.30359 20.22869 16.57106 16.98823 29.09295 24.24459 25.72547 39.59293 26.4764 33.03029 26.27166 33.3976 35.92771 17.96664 19.29767 15.06652 38.93071 44.02954 24.71841 47.51842 45.09545 54.44079 62.30088 53.12438 55.40217 24.86363 39.97749 42.40519 54.90173 51.99615ADVANCE Eastern Europe Standard 26.458 10.555 19.473 18.804 24.507 33.115 16.994 28.078 27.59 55.839 32.994 35.409 49.82 41.871 33.956 37.873 48.328 51.68 46.782 59.383 34.805 26.249 19.662 29.038 29.913 36.332 29.796 38.956 18.553 22.154 17.928 48.396 36.935 33.079 21.808 22.154 49.82 47.299 21.995 28.164 43.729 42.849 54.246 79.768 58.506 28.025 23.917 30.308 33.903 48.405 27.521 20.154 19.682 23.414 32.178 24.771 21.014 26.81 32.668 28.534 38.575 33.184 55.613 31.645 40.66694 28.59021 38.6523 52.19387 29.83287 53.33854 33.79053 29.7859 31.2346 33.01515 38.22303 38.04208 32.39136 30.10316 23.20776 29.40408 19.04206 26.40076 35.79385 22.33383 23.71919 16.65533 36.4582 39.78191 21.18962 36.49932 39.59545 35.78547 32.0905 51.7378 38.7195 24.76691 30.59412 17.46997 29.62094 47.91451ADVANCE Eastern Europe Intensive 11.967 20.722 20.474 18.401 33.365 34.595 23.104 37.186 30.786 47.689 41.296 41.955 54.29 37.858 48.896 45.532 45.771 42.895 49.972 54.024 25.191 16.328 24.24 20.89 27.298 37.995 26.359 35.474 36.205 26.601 24.654 38.249 40.915 21.038 15.146 26.241 44.466 42.874 30.322 48.456 47.537 55.962 48.734 70.787 62.206 23.618 28.313 31.868 48.458 44.762 33.571 17.641 23.065 27.39 27.335 23.216 24.454 34.762 27.767 33.269 34.191 39.575 53.69 28.157 21.54994 29.35984 26.49906 53.1921 26.22594 48.20788 31.08376 27.48818 32.47461 25.19127 27.38978 26.67583 27.21029 29.75567 17.23949 21.49884 19.07878 27.12563 33.40359 15.60769 19.08926 12.51399 35.04568 27.08874 14.69694 44.00909 35.16248 48.24521 43.78356 47.41097 35.98889 17.4069 19.52434 27.14406 31.61961 40.33113ADVANCE Full 9.5935 18.717 25.727 11.571 28.808 40.035 14.635 44.83 33.627 35.654 38.966 35.892 68.142 42.355 55.599 66.378 67.393 61.736 60.567 82.656 20.34 16.921 10.242 9.8726 36.524 24.196 13.45 35.511 26.31 38.686 32.323 36.834 37.18 23.929 24.502 38.185 52.356 49.187 29.165 49.351 41.515 51.003 45.04 53.897 54.617 20.765 22.805 29.953 47.092 52.812 12.143 7.4472 17.371 7.3023 28.619 26.705 13.894 33.259 32.666 38.418 35.417 45.221 38.431 35.628 42.1603 37.30267 48.5305 48.02745 48.05575 61.77785 23.84511 16.10311 15.0246 18.27231 29.28732 29.7255 13.40159 22.13662 26.18435 35.36415 29.3656 33.90398 34.90263 23.4347 19.64443 23.21131 44.91641 32.6395 37.45555 38.1339 42.07213 41.69351 52.10082 42.22469 49.57317 35.39449 30.20967 24.94091 47.84562 46.20828ACCORD BP Standard Therapy 28.51 24.513 33.4 27.157 37.275 49.384 30.206 35.588 17.131 26.509 28.455 27.515 42.865 37.462 35.764 36.121 41.452 49.432 31.232 47.924 33.98 32.11 40.861 32.991 33.844 43.999 34.827 43.638 23.189 29.219 28.894 28.621 49.13 18.945 31.463 21.723 36.238 50.51 26.102 43.729 24.281 36.923 27.059 38.423 24.282 16.157 26.334 27.705 38.997 33.448 23.039 25.02 38.453 30.422 37.195 42.692 29.845 35.574 20.181 22.671 29.708 24.679 45.801 25.356 41.53355 35.23118 27.93286 47.3615 32.35092 45.61885 31.0608 33.52794 38.5718 33.43249 37.88795 45.22398 39.20075 39.52075 23.60021 23.00364 25.49575 34.43875 40.56654 21.21092 22.01946 26.53827 38.86881 46.35282 23.9119 38.24344 21.65156 28.412 28.18736 49.8482 21.99386 14.80681 24.18649 23.88036 39.78749 38.18017ACCORD BP Intensive Therapy 25.823 28.086 29.702 31.861 39.628 40.754 30.538 33.807 12.722 27.192 29.88 19.122 46.57 17.217 30.149 35.974 36.705 43.489 31.184 47.356 28.604 29.884 36.267 29.508 35.59 39.373 31.346 39.673 17.262 29.169 25.348 35.531 37.24 17.14 28.618 28.298 28.87 53.6 20.075 56.286 19.314 33.677 31.139 42.106 30.99 13.806 21.116 25.229 52.899 34.893 29.782 28.992 32.259 31.588 40.645 42.724 25.215 37.405 10.452 21.72 35.447 22.131 47.182 29.34 23.51525 30.12917 27.88569 31.98894 29.70875 46.11645 37.28665 37.95161 34.33264 36.37462 38.19984 41.94378 43.16065 38.78465 23.80071 25.62863 24.39501 22.91334 36.7517 13.03507 21.57758 18.1426 35.49607 40.11149 21.60025 31.33347 15.51859 24.87374 26.04163 44.85812 22.16292 14.49694 26.54304 25.25171 37.02036 31.39971ACCORD BP Full 21.49 31.84 31.108 29.036 30.769 44.964 34.154 36.981 15.221 29.146 28.852 22.895 46.932 20.042 32.314 48.294 29.465 33.025 33.512 49.191 29.615 34.449 31.932 30.713 39.724 41.319 32.632 41.077 17.293 23.721 24.567 28.33 44.197 17.091 14.842 25.905 36.099 46.381 24.46 40.212 16.829 30.53 29.736 52.156 30.888 12.737 31.406 26.632 45.498 36.902 23.048 29.073 27.487 32.879 41.794 45.765 34.492 41.824 12.155 18.859 22.774 27.877 44.506 15.417 30.12171 41.45338 43.89624 39.12017 32.6751 35.41749 37.92087 33.93566 35.41822 31.69765 37.58302 44.2363 38.08958 38.92475 21.05149 24.95791 24.79171 29.70569 47.77445 14.91349 26.01881 29.57584 28.40917 46.88289 23.63492 32.69726 14.23104 41.683 27.38022 43.79436 19.53593 19.69994 21.33053 20.02587 45.59572 35.63632KP 20-34 5.5 6.2048 7.1937 4.3012 6.8007 5.8737 13.398 12.59 8.3964 8.9722 11.769 9.3408 9.1924 12 9.5786 11.091 11.402 12.062 11.478 12.247 3.5707 7.6322 4.6637 7.1937 6.6708 6.364 6.8191 9.4604 10.21 10.712 9.7211 11.651 10.464 11.325 12.51 15.692 10.851 15.273 10.32 13.048 7.1414 12.61 11.147 11.424 10.464 7.8899 12.903 11.258 11.113 7.5 5.172 7.3824 7.1937 9.4736 7.5166 9.5917 7.746 7.5166 5.7228 9.0692 8.4853 8.231 8.5732 9.083 7.905694 8.455767 19.38427 9.836158 10.95445 13.91941 3.674235 6.062178 8.746428 4.898979 4.743416 7.314369 6.763875 7.905694 8.031189 10.6066 7.889867 12.5499 9.578622 13.7659 9.604686 11.52172 12.09339 13.69306 12.24745 14.51723 7.228416 10.14889 8.732125 10.13657 13.43503 9.604686 11.72604 7.36546 13.32291 8.529361KP 35-50 10.149 5.7663 11.779 4.4159 11.554 12.767 9.9121 9.3408 12.816 30.299 22.153 17.93 25.372 22.293 25.11 24.546 20.378 23.89 21.154 17.161 8.4705 10.062 16.666 10.897 14.344 12.42 7.5166 16.109 17.299 24.744 26.763 17.557 19.326 21.054 23.441 22.544 24.218 18.927 20.585 18.675 22.483 17.051 24.01 13.937 29.912 14.748 24.464 27.686 28.766 26.158 4.7434 9.7724 16.394 11.236 12.718 7.2457 14.586 11.683 22.17 25.763 21.506 19.164 23.78 17.299 17.74824 18.35756 23.05971 17.64228 20.98809 18.10387 8.616844 11.64045 14.04457 6.363961 11.36882 6.576473 13.32291 11.55422 17.07337 22.16416 15.58846 22.81447 20.71835 16.50757 25.36237 23.5372 13.97319 30.24897 21.9032 24.19711 27.17996 17.25543 19.40361 24.23324 21.9032 14.37011 18.34394 25.43619 27.32215 25.69533KP 50-65 13.096 26.847 16.016 20.18 38.856 30.393 29.034 35.224 41.343 53.282 47.397 46.997 54.454 32.074 51.364 46.597 37.597 47.313 47.964 47.778 11.64 18.96 21.966 22.394 30.883 32.175 27.331 42.866 20.748 30.541 29.559 38.095 46.955 31.93 30.765 34.191 47.445 47.849 31.992 56.254 31.044 51.223 54.18 42.924 44.266 26.865 44.755 43.235 54.27 49.389 15.898 30.096 22.776 30.59 35.913 25.15 28.662 39.611 40.342 56.016 39.278 37.58 56.103 32.596 41.94341 61.15145 48.64412 62.95832 58.67921 54.24712 17.39253 26.14383 22.52776 25.85537 24.34132 33.48507 24.69312 36.30083 24.75379 36.75595 28.39454 45.63989 47.91138 29.72793 46.44351 37.66298 58.66643 46.38426 30.93542 61.5711 33.81937 43.30127 41.00915 53.89573 39.19821 35.03926 36.86801 35.8155 36.43487 39.15035KP 65-75 36.139 42.196 56.002 57.441 57.935 67.481 44.379 56.76 71.965 72.509 68.88 85.245 98.822 71.786 94.591 90.573 94.959 92.632 89.077 98.829 33.362 36.284 49.47 40.293 53.484 59.078 40.308 53.296 54.374 66.937 66.847 65.159 90.701 64.316 68.771 70.55 86.566 84.637 74.648 76.227 80.379 81.974 80.864 123.63 83.047 55.014 65.732 71.699 81.162 87.466 36.284 52.101 59.395 51.037 51.829 75.619 45.918 61.976 71.962 85.308 70.647 75.09 101.21 78.31 89.8916 87.95595 100.5709 98.99747 89.03511 103.8184 31.94918 34.35841 42.20486 44.09649 46.9867 60.62384 50.2643 58.30738 54.14333 56.56191 58.89185 75.14153 85.98546 52.12725 66.79072 63.23962 79.15017 89.4511 63.36995 73.74958 63.7299 84.65518 74.47651 101.6354 78.81466 58.67282 71.06511 76.84074 76.18399 83.86447KP 75+ 99.159 104.82 92.9 119.7 100.13 124.87 108.4 117.78 111.52 128.64 129.94 150.64 154.38 144.25 132.54 160.7 167.17 151.1 154 147.14 97.846 88.492 97.729 112.46 110.86 106.28 81.597 117.41 106.81 108.98 142.72 129.81 134.88 111.08 122.79 165.99 129.9 142.41 125.84 156.34 124.85 140.41 160.23 160.74 137.69 102.36 133.68 129.92 149.08 126.66 95.374 99.058 101.01 110.42 102.23 120.8 92.338 119.58 130.3 111.83 131.18 158.71 143.84 136.13 137.3617 140.0955 169.4358 164.3426 145.3909 158.6742 88.24115 101.0371 106.5692 112.8926 112.0658 119.3514 103.8027 114.2399 107.0852 106.3062 142.3561 122.6683 136.424 116.5408 133.6058 148.78 131.123 145.4802 119.3199 152.8905 139.6818 152.386 153.6945 142.0933 128.3092 107.861 120.3723 140.6867 144.5234 114.7584KP Total 27.012 31.046 32.13 45.529 50.042 50.035 31.073 44.287 48.692 70.967 57.066 59.839 63.361 55.541 69.353 63.776 56.852 65.856 79.157 81.434 24.369 25.778 31.964 37.502 41.384 43.763 37.745 43.223 48.472 43.828 54.481 46.863 57.388 40.993 50.576 51.636 59.073 63.907 52.82 69.69 58.666 65.682 64.995 68.475 63.814 47.149 58.557 56.744 57.089 65.071 27.579 33.587 32.508 33.82 49.087 44.688 27.031 49.715 54.293 47.464 64.304 67.31 71.754 54.084 67.6333 64.57061 66.46992 63.01832 67.30997 75.96921 26.64298 33.41574 36.00599 32.38226 42.51306 48.38994 40.72832 47.72194 37.19161 41.24802 59.83521 56.88368 63.48284 36.47512 61.19042 71.53507 60.76649 61.68015 63.92056 56.35162 52.45549 77.74874 69.36353 66.51686 69.70825 40.13799 52.09537 63.99958 48.40523 65.14261NDR 20-34 14.142 7.2801 7.0711 3.8079 6.4031 8.9443 9.8234 14.56 11.314 11.511 12.166 15.953 15.264 13.509 13.928 18.439 15 12.748 14.983 15.652 3.8079 8.9443 7.0711 11.424 6.0415 6.0415 12.166 6.6708 15.572 13.657 15.524 13.21 13.416 18.385 19.455 19.558 12.042 10.44 12.207 15.652 17.029 15 21.471 13.21 17.464 16.263 20 17.889 10.817 12.369 8.6023 9 12.51 7.0711 9.2195 6.5192 6.0415 7.6158 12.806 10.296 17.889 8.6023 13.038 11.511 13.28533 9.617692 15.44345 12.36932 17.26268 18.17966 11.31371 8.246211 7.28011 4.743416 10.77033 7.615773 9.486833 7.516648 14.1598 17.08801 13.72953 17.90251 11.6619 15.55635 12.90349 10.29563 11.85327 17 11.6619 13.28533 16.97056 14.76482 14.76482 19.30026 12.74755 14.14214 17.08801 20.12461 20 12.02082NDR 35-50 3.4791 7.8668 11.971 3.156 7.2036 7.1785 8.3939 9.8611 16.015 15.889 14.349 11.217 15.027 5.2541 11.011 9.1475 11.933 17.158 20.644 14.906 2.4846 8.0509 5.2535 6.753 10.098 5.1439 12.676 6.2702 24.521 18.897 16.139 24.936 21.794 12.668 12.58 15.909 12.263 13.519 18.897 19.201 24.392 17.317 21.276 25.138 24.415 25.059 17.262 22.908 20.005 16.474 3.9225 14.86 4.2041 8.7277 9.8031 1.6569 14.386 7.0428 18.218 14.693 21.276 19.551 20.782 7.3751 15.47702 10.2868 13.88612 17.26176 15.15982 10.2868 1.293926 8.922065 9.100233 9.100233 10.5606 7.738814 12.0991 9.409051 13.82169 26.0036 26.21155 22.68191 16.56711 12.66757 8.148021 13.82419 22.40949 14.32656 15.66273 14.40105 22.23835 25.58822 25.82306 24.45347 22.1804 18.04476 31.12148 21.09095 23.75258 34.26334NDR 50-65 17.891 9.7274 13.136 11.555 31.708 22.168 15.834 35.663 43.507 26.613 45.286 37.932 38.031 35.204 32.024 37.565 42.975 31.105 34.39 36.116 8.9366 21.135 8.7915 15.571 26.032 18.188 20.484 26.256 24.104 32.391 24.149 45.637 30.804 18.992 19.787 22.485 33.039 25.075 27.997 30.039 41.723 44.672 47.14 59.595 48.709 38.119 32.435 21.704 37.174 51.342 7.0834 11.145 12.534 7.8257 27.46 18.858 15.102 37.027 46.585 47.708 35.238 43.009 38 30.407 33.85927 43.85127 35.32928 31.66983 35.13406 29.53408 12.47293 10.13539 6.261793 10.27512 29.31467 15.75062 14.21696 26.85022 29.46914 27.48531 44.07251 38.21573 31.31054 23.25636 23.16182 21.69152 26.6041 32.5912 27.57394 40.83271 48.50285 50.19225 38.68496 46.73588 45.49793 37.78749 23.29502 30.75461 42.87099 52.76482NDR 65-75 14.073 21.346 10.841 15.708 18.784 35.263 7.7779 27.69 44.403 46.825 70.149 49.257 54.082 49.345 50.045 59.254 43.556 75.738 47.528 65.847 18.273 7.6296 12.101 5.5778 25.973 33.474 12.822 38.93 39.74 43.481 22.242 33.155 37.915 23.416 25.496 26.397 43.248 47.098 26.089 56.466 63.084 59.101 72.45 56.797 69.441 41.789 35.606 39.423 38.263 52.703 11.16 15.122 4.2598 13.299 33.336 24.289 14.982 35.605 65.873 50.457 37.856 45.25 53.595 49.299 57.75296 61.75636 60.24563 46.66633 60.34461 58.69228 5.735337 7.131626 5.228584 4.390227 24.14212 28.46089 9.469957 43.91512 32.66123 37.76925 23.64534 44.32613 39.90093 24.29774 27.93038 22.99544 50.39437 44.11449 25.84105 43.69771 78.16877 56.0371 63.87419 72.15381 63.96221 38.58528 57.26395 29.29987 49.02038 57.81275NDR 75+ 4.9302 3.9405 9.646 6.5967 31.971 39.6 9.539 45.964 61.282 51.167 44.19 56.247 66.554 62.657 71.11 87.049 78.598 74.18 68.482 82.278 37.778 34.763 34.741 43.262 35.488 53.801 36.428 57.353 32.313 24.383 37.963 32.946 42.872 40.589 46.008 50.61 36.45 50.757 45.189 49.257 68.319 71.87 65.868 82.903 75.325 31.067 35.751 29.122 37.37 46.507 4.437 9.2113 8.6915 22.053 16.992 39.587 5.0809 44.852 50.593 48.763 43.963 50.908 66.099 78.538 76.52302 81.35006 54.73486 67.27242 46.33555 70.76712 30.16743 38.59784 42.90291 41.3179 49.00278 52.04892 37.82221 48.73625 24.54569 24.45023 26.29194 38.0516 39.53553 37.87195 34.57242 46.20169 29.91583 47.25715 29.66292 57.34208 71.95751 59.72046 61.16524 67.41699 67.77896 36.4933 44.41335 28.56821 47.28318 52.19237NDR Total 13.898 19.38 3.1788 20.93 32.329 19.346 10.118 34.22 44.61 45.177 50.088 53.419 46.241 52.853 27.51 44.418 33.388 57.029 55.888 51.534 11.534 13.855 13.496 20.061 34.313 30.003 7.9171 26.408 29.15 36.926 24.805 39.654 29.092 16.818 25.866 24.14 30.1 36.591 36.486 30.215 63.553 56.135 43.049 57.91 40.763 41.717 28.898 38.225 48.901 33.703 16.769 9.5935 10.261 9.8313 28.126 30.16 8.0752 30.913 48.334 38.718 44.689 38.154 44.04 52.566 48.4195 41.84372 50.2883 54.23248 48.17582 51.42806 18.91133 7.550838 5.77893 8.516254 28.56676 22.35988 3.492342 23.68061 41.878 33.82512 32.424 30.38986 34.7937 22.30107 37.52046 16.77526 34.11352 27.60075 20.56149 38.68867 58.50601 45.43585 52.49144 46.59433 61.90755 45.88399 30.31127 37.6283 30.83695 42.62731AHEAD Control 18.778 24.597 28.559 27.981 34.766 36.195 25.11 32.715 34.394 55.609 38.337 61.691 60.303 40.611 52.243 61.659 52.7 61.365 46.605 53.837 21.473 25.795 29.957 27.842 38.153 42.807 23.358 41.268 28.329 32.242 36.866 31.449 38.413 22.953 30.839 34.847 55.525 43.069 31.899 41.001 43.263 49.169 46.014 74.344 49.42 17.848 39.815 40.497 43.32 40.616 23.507 22.345 26.421 27.97 28.304 30.149 21.093 37.469 26.141 36.646 28.059 35.06 51.727 38.577 43.53047 64.9751 54.00488 51.16382 49.44008 59.7976 28.63986 25.82049 24.60092 23.90655 27.168 38.0577 17.00947 27.48774 20.35091 26.10068 36.07699 35.49074 38.65183 28.21581 35.79145 43.87927 52.22269 36.80451 36.78522 40.87817 34.07726 47.77666 43.25142 61.31247 46.77165 24.35322 40.71889 22.91685 33.43361 47.61664AHEAD Intervention 24.665 24.383 27.679 20.439 40.165 38.344 29.354 47.738 35.371 39.702 48.979 46.601 56.426 43.622 58.932 61.483 43.568 67.278 52.426 63.221 18.847 23.971 23.667 22.425 29.672 35.583 25.531 32.379 33.321 43.514 39.866 41.776 56.068 34.025 37.816 40.004 40.568 59.581 31.885 58.272 46.667 46.502 55.998 66.557 54.943 27.168 44.18 32.131 59.262 51.548 22.446 23.389 27.703 25.749 25.008 35.703 24.013 34.052 42.65 44.969 42.928 43.961 53.665 42.496 41.91181 55.99385 49.56294 58.77224 44.78362 57.37753 21.84316 23.34741 29.28081 21.25215 26.71213 35.0426 24.64825 27.13791 20.80084 21.84892 31.95137 40.3842 40.44815 25.98114 34.42281 39.94131 45.62082 46.14046 33.75297 51.83827 43.63663 42.73797 44.05777 53.02194 44.81442 36.91942 30.35818 42.62011 48.42627 41.37746AHEAD Full 28.515 24.81 21.218 32.673 37.072 40.554 19.556 35.739 39.383 42.09 54.543 48.003 60.684 41.95 57.689 57.384 55.745 68.753 53.517 66.514 23.645 25.378 24.886 29.246 32.052 36.305 30.916 37.148 26.698 46.371 33.797 45.567 45.73 22.727 40.477 55.652 43.015 51.288 42.855 48.706 47.469 53.391 54.767 64.524 54.448 37.332 45.386 38.795 55.383 64.194 22.816 20.621 25.29 27.984 24.336 37.29 21.504 36.004 41.041 44.785 39.969 41.08 56.404 42.77 50.89533 57.28411 46.07094 53.57681 52.95893 58.47796 21.64546 27.67908 28.79754 21.30214 25.00884 34.10649 22.04209 33.20138 22.38383 27.77382 33.83302 41.92292 45.88364 29.68504 30.9056 42.51367 36.94713 49.04273 41.25355 43.30423 44.02245 51.83721 49.95567 53.5671 47.77787 30.89579 41.021 26.64655 41.56244 40.77324ADDITION Routine 21.477 23.157 20.031 12.01 24.213 22.057 27.6 34.471 34.835 43.692 40.583 40.181 36.094 23.457 31.185 24.642 24.264 52.711 31.205 46.22 19.538 23.927 22.299 17.139 31.563 22.902 20.767 35.637 31.725 26.828 22.984 39.972 38.223 22.31 23.114 16.993 27.244 23.796 28.111 32.947 44.286 41.62 53.132 48.952 51.284 27.468 29.009 38.373 35.089 41.237 8.1854 12.309 12.99 6.4031 28.275 14.883 16.179 24.824 27.464 28.618 28.102 31.121 29.508 22.119 21.41261 24.74874 15.37043 30.3768 24.25902 32.64583 11.24722 17.30607 14.33527 14.05347 23.22714 20.0624 18.5809 20.05617 22.10769 25.67586 20.98809 33.5 21.6044 11.03404 19.39716 17.5 24.02603 17.28439 16.07016 27.06474 36.7015 28.97844 35.22428 30.32326 35.87478 24.20227 24.71336 25.17439 24.56624 36.01389ADDITION Intensive 16.823 19.013 16.926 19.072 27.304 21.731 29.555 35.267 42.977 39.424 45.456 44.13 37.33 42.376 35.207 31.737 27.861 42.886 36.912 46.666 22.611 27.175 21.915 20.628 44.011 24.398 22.288 40.475 33.604 33.384 30.875 33.875 39.68 13.739 27.308 24.156 37.503 26.424 29.09 35.809 42.435 57.563 45.763 66.725 52.804 32.458 38.994 36.507 38.085 46.556 8.1548 17.958 11.747 20.537 19.274 14.396 12.5 28.067 37.49 33.264 40.762 36.517 31.157 24.749 30.68795 26.1247 23.39872 22.15852 36.17665 36.23534 11.42366 18.20714 11.86381 15.41914 21.58703 20.25463 18.43231 27.15695 28.59196 33.85631 29.81191 32.47691 26.41023 16.36307 16.27882 19.67232 36.11786 23.5372 21.46509 28.93959 37.59654 36.7049 34.97499 38.55516 47.22817 24.59675 26.97684 30.35622 30.60637 42.45586ADDITION Full 17.939 22.073 16.198 21.873 30.998 28.21 19.406 35.633 40.213 31.189 46.375 40.218 40.065 29.789 30.465 28.25 33.259 36.369 29.308 36.68 12.818 19.462 24.968 27.957 28.205 24.601 17.863 40.945 26.277 30.078 30.919 45.706 29.647 19.422 25.084 14.597 30.474 25.868 30.039 30.141 44.706 52.399 51.414 65.564 52.866 35.013 37.047 34.144 34.247 45.86 11.738 13.559 7.0218 11.452 24.402 14.225 16.913 28.769 33.917 30.744 40.783 40.74 33.283 17.845 22.66642 20.97805 18.68532 28.06151 21.60937 24.6935 10.02365 16.93811 17.08405 12.93601 26.52758 16.90005 13.61447 22.89159 21.8886 24.52128 24.14775 30.19042 30.71595 14.93447 21.65697 19.09516 27.01575 19.48307 18.63947 27.28109 41.39072 46.17266 32.03258 39.75077 41.27616 20.68094 27.4063 25.11424 29.89624 29.37477UKPDS33 Conventional Correlated 45.267 48.165 50.279 44.354 85.682 78.447 61.285 79.29 76.665 75.754 72.922 77.845 82.446 71.425 75.426 81.773 61.662 87.822 82.649 97.455 24.591 47.955 47.674 36.719 72.972 70.254 62.816 81.202 44.264 69.591 48.898 78.556 79.142 43.305 64.463 46.539 78.03 75.656 72.605 97.437 86.938 95.336 98.949 100.29 97.218 69.669 65.509 60.233 87.301 94.686 47.78 56.406 66.532 52.335 85.975 69.521 63.896 88.889 70.208 74.407 87.783 71.231 90.486 58.433 75.9312 81.03283 61.94338 83.88925 86.57528 97.6052 28.76874 54.54962 52.10211 36.35506 71.5431 70.24705 69.51551 76.25096 45.39535 51.54902 62.1322 82.53225 81.30782 45.46068 56.03475 40.80394 83.58831 79.55051 64.45454 103.5857 91.35691 88.42272 92.23652 121.1207 96.43884 69.41598 79.95182 57.85938 75.66109 98.18024UKPDS33 Intensive Correlated 58.153 63.435 62.648 49.906 72.328 73.935 71.722 85.95 78.744 77.222 91.341 91.559 89.211 74.21 79.723 91.085 83.398 95.026 87.4 105.38 29.44 46.262 56.478 39.845 80.567 75.878 62.906 83.29 43.558 63.7 74.749 82.989 74.279 48.664 61.59 57.095 73.254 87.052 56.392 92.772 100.74 103.06 109.43 109.81 98.848 73.764 75.837 71.146 100.34 99.191 40.841 59.543 61.24 59.525 83.289 79.25 73.754 87.951 71.03 86.34 85.791 77.623 99.179 65.816 77.12232 79.24033 74.15441 107.4359 81.77402 105.4306 44.07782 51.6596 57.44148 30.80047 76.00037 66.95171 66.76633 91.48774 58.37505 63.44901 59.81655 86.32927 73.29949 49.72029 61.24794 57.92892 78.25342 76.97434 65.35423 86.75964 92.10485 110.1007 99.76378 121.013 105.5843 65.99251 78.08494 79.82909 97.06665 94.45523UKPDS33 Full Correlated 49.732 61.347 58.247 51.943 75.597 75.888 61.383 79.861 73.16 74.377 70.706 74.551 94.987 54.105 85.574 70.553 69.493 94.038 87.274 108.44 34.783 55.355 52.427 40.482 69.963 73.728 60.31 83.529 52.505 65.098 47.423 71.601 78.2 41.646 56.492 50.611 91.536 74.358 58.424 82.172 103.87 97.805 88.254 113.65 107.59 60.158 79.864 64.315 83.29 101.24 48.064 62.835 60.347 65.423 80.697 73.667 65.893 75.898 83.424 84.169 81.143 85.172 93.022 75.956 82.43009 81.15555 64.89135 97.08221 89.1389 101.5367 43.73129 53.17059 51.62682 42.61983 73.79085 68.25722 54.65431 85.79803 47.45659 65.63699 51.0235 68.73408 74.87176 52.63331 71.27339 48.75421 76.22479 82.24884 68.0597 83.10534 89.53167 95.37643 78.15692 114.3226 96.36085 66.18341 66.04769 65.61154 96.63077 95.75197ASPEN All Placebo Correlated 13.285 24.233 17.479 24.403 34.921 33.147 25.164 34.194 39.335 44.292 41.21 40.162 41.842 36.421 50.092 31.992 41.623 36.287 45.856 50.836 14.756 20.421 11.158 15.443 24.238 32.195 13.901 38.177 22.836 19.164 23.415 34.187 31.02 26.391 16.055 28.236 27.982 33.682 22.995 36.753 47.542 48.386 52.024 53.486 39.62 27.735 25.145 25.07 37.051 34.533 17.421 21.178 20.341 16.718 32.031 34.42 24.269 36.776 32.722 30.174 41.967 35.064 33.593 46.837 43.72928 32.95072 52.5 47.91138 50.47276 41.02743 8.573214 19.9875 16.76305 12.05197 21.50581 38.29164 12.74755 32.17919 30.15792 25.10976 19.38427 26.27261 35.34827 29.46608 21.80023 27.38156 34.44198 35.22073 30.33562 44.79118 37.24916 57.38467 43.9033 44.77443 47.82782 25.37716 26.29639 28.00893 34.56516 46.36ASPEN All Atorvastatin Correlated 29.808 28.116 24.119 18.668 33.44 39.074 25.333 35.334 46.717 42.362 44.368 33.451 58.348 32.5 41.584 44.769 48.386 52.529 42.317 54.404 9.3541 12.981 12.319 14.603 29.896 24.814 18.18 30.418 23.399 29.279 26.782 43.735 37.862 25.725 35.986 42.08 42.294 41.107 37.249 37.336 47.36 59.879 47.069 50.289 39.032 36.854 37.99 39.338 47.389 42.953 10.92 18.588 17.19 15.788 32.55 32.631 22.699 33.2 29.875 31.777 33.17 38.341 52.863 34.63 44.07664 43.061 32.21025 42.45292 38.8748 50.60632 8.674676 17.61391 12.8355 12.29837 19.24838 21.38925 14.93318 32.69557 22.6495 26.89796 23.07596 30.4795 28.42974 23.83275 27.59076 36.15937 35.15324 35.3235 22.45551 38.50325 36.94929 42.21374 41.60529 47.58676 37.11469 34.1504 22.47777 28.69669 32.76049 45.93746ASPEN Primary Placebo Correlated 27.861 31.173 28.605 32.519 33.399 38.331 29.517 32.488 46.699 41.382 45.73 45.481 57.031 36.562 37.074 36.613 44.167 41.14 39.294 52.707 16.109 13.964 15.281 13.191 24.031 25.402 21.178 37.463 25.783 27.272 30.344 33.061 36.407 21.442 39.411 33.264 34.132 35.798 37.236 39.563 45.415 46.144 47.101 50.376 42.585 34.088 39.941 33.782 49.442 45.809 25.865 31.918 29.958 28.588 34.384 35.746 28.302 40.863 41.076 43.974 39.771 50.963 52.666 38.177 45.92113 38.06902 39 53.72616 45.63442 49.94247 15.31339 17.13184 15.50806 14.5688 21.03568 22.39978 19.68502 25.22895 34.94639 26.55184 32.05464 42.12778 42.77558 27.42718 29.23611 28.53945 45.73565 38.46752 34.5 49.64625 55.11125 58.25376 46.53762 56.99781 60.44419 38.60376 31.86691 27.43173 39.21734 41.87481ASPEN Primary Atorvastatin Correlated 27.902 31.105 34.044 27.505 46.564 33.838 33.812 39.185 33.963 39.01 59.233 40.872 58.282 36.152 44.184 32.661 45.36 47.547 40.657 58.269 22.405 18.486 18.967 20.922 25.952 26.566 26.618 34.187 42.597 36.215 27.762 37.56 39.702 33 36.377 25.884 36.135 37.407 40.82 40.143 51.473 48.376 59.245 53.54 43.442 31.788 32.882 41.728 42.971 47.199 21.645 25.204 24.094 27.322 24.769 26.481 25.928 35.669 30.655 41.164 36.27 43.761 38.752 41.629 32.93554 37.74917 41.11265 42.24334 39.17908 46.65297 10.54751 18.22773 19.58954 17.53568 27.80288 16.48484 13.38843 28.41654 23.16247 25.91332 31.70173 32.76431 38.52921 27.57263 24.87469 20.93442 31.253 39.48734 36.20428 43.15669 47.60777 55.93747 47.38934 48.81342 44.60661 27.6315 30.20761 32.76049 37.04727 49.48485ASPEN Secondary Placebo Correlated 23.574 16.016 24.734 23.049 35.295 48.985 21.319 39.054 14.089 18.152 29.962 18.567 45.796 30.154 49.158 47.681 41.322 52.998 50.624 57.064 46.449 39.579 48.885 38.746 46.877 69.141 42.137 54.679 19.609 27.645 12.865 34.598 52.7 23.717 22.638 18.337 30.508 45.984 24.047 33.805 20.555 35.99 23.049 54.309 22.305 16.148 29.937 19.538 45.108 28.862 16.919 22.125 29.862 24.3 31.67 47.786 20.211 32.97 14.748 16.086 26.594 19.962 54.943 56.655 40.46295 37.74917 39.29058 52.04565 45.8939 52.82518 36.12132 38.94868 46.68779 44.42691 49.37104 53.64233 35.57387 51.99519 18.29617 31.21298 22.14159 26.86541 38.78466 25.23391 25.10976 21.6044 36.46231 55.18378 24.26417 32.8291 17.24819 28.92231 23.30236 52.59753 29.27456 9 32.21801 9.66954 38.94226 28.39014ASPEN Secondary Atorvastatin Correlated 10.332 19.474 41.228 25.647 36.397 57.981 23.184 46.696 35.986 33.238 45.547 28.102 60.488 60.616 62.215 63.522 63.992 69.186 76.31 73.883 21.639 22.192 29.065 19.609 34.735 54.998 23.452 32.661 14.195 38.321 19.072 37.733 62.911 42.506 51.24 46.211 50.282 67.428 38.665 52.084 41.662 43.595 48.528 62.036 35.788 25.505 31.105 32.78 61.029 34.803 15.248 15.756 28.018 17.875 30.15 50.747 24.073 36.404 22.929 24.3 36.503 25.249 49.492 62.964 48.17157 51.46358 60.04373 65.23228 55.72253 64.98846 26.19637 28.08024 37.60984 30.74492 31.08858 52.99764 31.00403 32.41142 8.645808 33.68605 19.01315 29.31297 40.88704 43.93177 36.23879 36.1317 37.38649 64.78812 38.9551 45.30453 28.5263 34.86402 28.5263 60.768 29.85381 11.16915 33.72684 23.09221 50.46781 35.17812ASPEN Full Correlated 23.646 9.6372 22.229 11.837 28.599 30.089 14.138 32.336 18.937 38.372 31.873 22.724 34.357 24.174 32.751 49.185 33.221 35.198 35.311 50.387 8.1317 15.996 16.375 14.642 23.582 27.895 17.745 25.522 18.885 16.02 11.678 17.653 41.087 7.9136 21.334 24.06 29.528 27.076 18.361 36.389 33.292 37.916 38.424 49.806 27.002 27.85 28.515 24.635 32.429 33.636 8.2689 25.002 17.625 17.216 31.932 30.494 15.56 30.998 40.31 22.724 20.252 39.964 46.132 23.294 35.51232 34.6356 41.81357 43.10887 32.64008 49.65254 9.791578 16.29033 15.60849 15.34194 32.04099 29.31083 15.71226 29.47244 14.58167 17.37455 19.27109 26.18444 25.07738 10.0312 13.51388 19.29702 34.85147 30.03123 23.3907 32.65157 30.96571 34.25456 38.82171 38.53408 43.91327 15.99609 19.1017 18.86465 39.47943 36.00521ADVANCE Standard Correlated 17.521 19.42 13.12 8.7096 30.411 49.699 16.036 38.234 27.944 31.312 38.443 19.183 50.616 47.79 40.46 26.699 48.574 59.344 52.305 58.576 14.092 12.649 15.095 13.299 18.369 29.715 9.7468 22.316 15.418 17.772 30.81 31.987 26.838 22.383 36.385 34.107 39.746 48.612 30.956 42.322 32.582 32.998 29.554 58.859 42.947 14.358 19.213 23.364 26.897 23.373 11.778 12.392 11.582 9.7248 20.87 30.993 17.96 25.211 25.464 17.234 26.476 25.017 32.437 36.483 32.02454 32.90462 41.58983 45.83199 28.7253 42.44829 19.97498 23.31768 18.49324 15.74802 20.733 22.50079 14.71637 19.90334 18.7959 26.45481 17.39458 22.92846 30.80121 21.12548 19.30581 22.74078 24.00893 32.13587 24.75595 28.76754 27.1609 21.92846 41.83129 48.36764 26.82483 18.31861 24.98571 20.52177 26.61364 32.58177ADVANCE Intensive Correlated 23.655 22.659 20.539 31.767 33.698 36.149 21.587 22.602 35.503 33.992 29.089 36.859 43.314 46.765 39.234 56.829 58.384 65.032 43.364 51.593 11.526 14.808 12.621 6.6009 11.508 28.284 7.8376 25.191 10.67 30.859 28.4 36.448 32.018 32.127 29.742 26.987 40.527 52.267 38.868 48.958 33.903 42.212 31.442 56.658 43.609 21.102 38.811 28 31.453 37.296 7.4642 12.13 16.699 14.177 21.394 27.41 5.2644 30.419 32.846 26.243 34.042 32.479 52.579 36.633 39.50768 34.4176 31.58435 52.26854 30.65942 46.19215 13.73733 9.978548 8.693183 13.83061 12.56412 24.13948 8.99206 21.49419 18.14229 10.55597 6.77179 25.53149 30.89383 18.8035 14.75514 20.47298 31.34827 43.86831 16.49242 29.76815 26.99471 49.80534 34.89372 49.4816 39.11704 16.16875 26.62169 16.25247 33.78081 34.88757ADVANCE Asia Standard Correlated 18.724 25.609 40.861 16.31 36.691 21.401 25.076 24.487 27.419 29.292 26.933 21.968 35.637 45.917 50.713 53.335 44.922 38.533 49.327 46.467 13.609 8.8769 14.826 17.234 11.891 19.875 17.012 10.334 23.605 14.17 24.483 19.504 14.636 27.583 31.113 33.006 31.327 35.553 24.421 28.007 18.708 27.313 25.729 37.164 27.557 14.318 17.703 19.834 18.039 19.733 18.873 19.277 18.542 16.547 20.63 26.374 20.736 14.608 24.273 22.825 22.231 18.958 37.595 38.626 32.48692 49.49545 37.79153 36.57048 41.17524 32.87856 26.35906 20.94278 12.51399 19.86957 16.31564 21.19434 22.63184 14.41527 20.95233 14.63557 16.79286 15.60769 25.97306 27.64778 21.9545 21.72556 26.15722 37.32292 18.6333 21.9545 21.94994 16.28496 20.81826 31.57214 24.67793 21.83575 10.0896 15.45962 17.12308 14.09255ADVANCE Asia Intensive Correlated 27.335 25.9 24.417 24.36 31.991 44.49 22.356 19.504 28.443 24.31 15.64 23.609 26.495 49.878 51.227 56.007 50.933 45.352 36.827 49.289 17.81 15.245 11 7.0427 11.1 24.519 14.839 13.145 13.711 12.783 17.748 18.374 27.925 30.179 23.723 30.338 30.189 40.195 26.676 33.49 22.852 19.115 23.554 38.213 28.869 13.55 19.488 15.192 26.332 18.942 21.052 17.17 12.239 23.85 22.064 26.45 16.395 14.785 21.652 25.42 15.531 20.562 23.761 32.37 39.24793 34.03234 39.40051 52.16512 45.00222 37.11334 22.08619 17.42412 9.338094 15.60769 12.08305 16.16168 22.78157 9.327379 14.40139 11.89117 12.09959 10.31504 20.63977 20.86624 18.97367 29.55334 16.77498 25.45584 22.81228 18.68689 26.45373 17.3839 17.09386 36.54586 18.0942 16.79286 20.76054 14.24079 20.92845 8.876936ADVANCE EME Standard Correlated 15.485 27.68 29.168 20.435 37.876 37.614 39.56 36.469 32 47.935 43.19 46.056 71.495 36.083 52.377 45.308 59.907 64.053 63.619 73.485 12.633 16.577 10.982 19.774 26.51 35.925 19.56 36.682 15.944 24.319 22.592 45.915 49.874 23.074 27.452 39.403 46.665 46.435 27.792 57.545 50.878 66.126 55.221 76.129 54.312 24.799 27.052 41.061 59.284 62.938 7.9498 21.166 20.707 9.3059 29.661 28.716 20.07 41.658 28.559 40.826 45.131 46.797 49.848 32.438 49.94797 54.92176 53.09426 45.54558 39.78945 65.18435 15.34927 18.85736 20.50853 27.9249 31.18333 27.62245 23.24651 36.06383 13.31165 32.83291 16.5106 38.704 46.15626 21.2744 27.42262 37.75712 50.12385 47.16567 41.57162 43.57063 40.78725 45.00444 37.39251 78.31986 44.78616 16.49848 30.91602 23.45208 47.23346 45.51703ADVANCE EME Intensive Correlated 22.943 24.896 24.54 21.119 33.245 43.056 25.53 53.115 47.962 50.436 59.693 55.832 62.718 39.108 61.49 66.298 66.846 68.491 56.761 76.539 12.182 13.394 18.857 16.655 32.958 39.444 24.633 41.864 19.142 43.433 31.375 55.299 49.491 25.911 32.305 43.26 61.673 55.328 39.92 57.067 64.379 58.052 49.699 68.069 43.079 23.917 39.454 35.319 59.147 72.547 8.1363 8.0498 19.642 16.407 31.324 35.128 18.698 40.443 39.054 40.252 49.311 46.197 66.234 33.811 36.82391 58.36437 52.1977 63.59245 36.96214 58.75032 14.46375 19.59081 22.37856 13.28909 24.90381 31.01935 20.17424 35.60618 12.28007 26.43483 20.63977 39.48417 38.37447 25.11971 36.15799 47.10414 30.16621 51.78031 28.69495 50.29513 52.36411 44.07494 40.91455 65.45533 59.96499 34.01176 32.60368 21.94083 24.09149 43.82921ADVANCE Eastern Europe Standard Correlated 20.943 24.548 26.941 15.881 40.09 34.863 21.638 48.822 35.465 36.395 35.097 44.322 56.361 34.17 49.283 32.041 34.234 66.699 37.283 61.124 29.913 27.677 21.749 27.633 24.323 25.267 30.262 35.919 19.94 30.935 31.362 42.14 46.26 24.042 25.187 28.217 41.384 49.319 30.077 38.299 48.224 52.249 50.036 44.522 52.52 23.711 32.184 25.338 39.588 57.857 16.285 16.775 12.091 12.946 18.601 21.596 17.877 29.88 31.67 36.962 40.586 30.216 34.612 33.296 32.56378 30.00333 42.93716 53.73639 38.08937 52.62509 28.10694 26.16486 21.48953 31.08697 32.47461 31.40701 31.1705 37.83649 25.10378 18.96312 19.95495 36.53491 38.49935 15.70987 19.15202 18.01111 28.01785 34.17894 26.69457 32.97272 35.27889 58.27349 38.69884 59.97666 44.08174 28.59021 21.00476 22.39196 32.95148 47.68438ADVANCE Eastern Europe Intensive Correlated 17.861 22.786 16.715 19.095 45.614 31.632 27.554 40.425 41.627 36.505 52.134 36.434 46.512 36.611 51.231 36.48 55.633 65.617 54.571 71.718 22.159 19.483 26.207 21.387 27.166 31.426 23.975 31.947 15.199 41.924 17.601 40.856 35.844 27.677 43.779 16.236 35.477 44.052 33.1 45.087 52.536 48.565 55.096 71.669 47.737 18.417 32.539 30.143 54.628 44.306 12.791 19.975 19.38 19.478 22.113 21.213 16.864 28.45 28.277 22.694 35.634 25.884 59.983 25.819 33.56188 41.2068 28.35489 50.27723 35.98611 60.3904 28.17801 24.84754 29.91989 28.33725 22.3875 34.33948 29.90318 30.9645 20.68816 26.37802 25.11573 41.15823 31.73326 12.56185 25.5147 18.94202 35.64267 36.87004 21.71635 39.5525 41.7229 46.23202 42.53939 47.7284 57.27478 30.2721 32.41913 26.81418 37.82856 50.14778ADVANCE Full Correlated 25.038 28.816 41.974 27.452 42.062 49.246 34.053 54.255 41.8 51.655 48.411 48.449 63.804 55.804 60.063 78.97 59.822 82.371 56.344 85.497 7.5711 7.5992 7.9577 12.114 37.264 35.541 16.354 32.51 35.352 38.524 25.404 46.193 43.694 28.798 42.098 37.991 50.243 67.205 36.374 66.878 50.045 64.357 65.748 69.838 64.501 29.767 46.001 28.082 57.299 58.586 15.068 15.599 17.498 15.79 38.999 36.017 25.717 40.356 38.907 52.672 47.964 46.269 57.087 54.518 43.43376 61.60191 51.94845 63.19307 52.18581 67.4797 10.78482 8.117183 11.80918 8.833911 22.39352 24.89772 17.12228 34.54047 15.68574 30.29226 45.3612 46.28543 44.75554 33.68851 36.092 27.35579 35.55958 54.29999 32.48602 48.74053 52.14062 53.76599 40.98157 71.20553 65.24953 26.24981 28.7237 27.92677 43.21941 48.65101ACCORD BP Standard Therapy Correlated 24.237 30.271 33.887 30.396 39.756 50.205 30.34 45.332 21.706 38.969 34.169 19.678 54.395 33.051 51.574 48.092 34.08 52.764 50.033 52.125 30.817 30.652 36.711 28.475 37.993 53.521 36.253 42.087 26.035 28.775 25.983 42.59 48.959 25.032 26.795 30.704 41.789 57.561 31.505 41.731 25.754 31.807 29.792 67.646 41.916 20.849 34.51 24.522 40.828 41.779 19.398 28.04 30.845 26.704 39.586 43.797 26.64 43.829 19.49 26.964 35.037 28.347 63.373 28.615 44.06649 52.78231 41.55092 46.37686 35.86904 59.5278 35.12023 33.69885 35.99173 32.61607 40.12572 51.35296 37.90296 41.99455 19.04072 32.72838 25.95774 30.53617 54.62118 32.48625 39.07797 22.81708 48.90226 48.56546 34.25182 36.4712 22.5587 42.84733 28.1803 52.232 41.98295 23.28011 32.49563 20.98931 41.00171 43.67219ACCORD BP Intensive Therapy Correlated 22.759 26.849 31.303 24.947 38.882 45.231 32.554 43.101 24.325 31.458 35.395 26.202 51.54 36.002 45.17 46.063 43.523 55.02 56.108 60.385 30.771 34.324 36.168 34.187 32.781 59.873 25.501 40.049 19.063 27.025 27.043 32.297 54.01 16.401 28.798 24.4 44.664 47.649 33.599 41.81 24.721 40.31 29.765 62.36 44.322 15.889 40.519 25.97 46.556 41.602 21.739 25.933 32.606 28.51 36.942 43.601 27.513 39.022 11.729 38.717 37.311 25.168 55.454 33.063 39.57478 48.10015 27.96445 54.60203 47.61343 52.66351 33.02433 33.59707 39.64396 29.90756 42.66624 55.26001 42.4041 41.48106 18.44696 32.09817 23.85133 34.80454 45.32436 19.58391 21.41055 24.17664 30.60695 46.28738 29.6646 41.6705 20.57769 49.54569 29.57533 51.12334 26.60166 14.93586 27.86505 24.56919 41.45789 43.35701ACCORD BP Full Correlated 13.88 24.651 31.038 21.632 37.071 52.43 26.175 48.886 26.399 29.778 42.579 22.297 57.913 35.735 45.136 50.136 47.044 54.41 38.64 66.507 29.04 40.704 34.141 29.056 40.273 52.928 29.494 45.75 22.879 34.912 18.698 36.586 54.144 28.805 42.526 25.569 47.247 64.511 28.663 50.446 27.451 41.303 33.375 56.733 32.23 21.283 35.059 27.228 47.147 40.462 21.79 27.594 29.962 20.397 43.15 43.951 28.443 41.862 17.425 27.668 37.803 29.688 57.204 40.098 48.15596 54.05938 59.28063 52.39668 47.13496 46.68427 32.18632 32.29646 36.55753 33.15855 44.15136 46.00231 32.96129 40.58927 17.68585 39.27147 24.18708 36.86707 55.43185 23.02099 22.77551 23.90693 35.53554 51.00785 26.3669 47.19342 21.68056 34.73456 21.53892 46.38952 35.16165 18.31942 27.98954 34.11113 41.0552 48.13939KP 20-34 Correlated 8.4705 14.221 9.5656 12.47 8.4261 7.3314 10.416 11.853 10.368 11.478 12.952 6.3048 12.093 9.6825 9.3675 18.615 17.951 14.018 14.577 21.581 6.6895 9.2871 9.0967 4.272 5.0498 7.0887 8.2916 7.1937 5.9791 11.325 6.8007 11.906 9.5656 17.342 14.891 15.443 16.394 24.439 17.161 13.739 12.639 14.916 8.9861 10.84 10.712 11.705 16.132 11.769 10.759 9.4736 7.5166 13.766 13.874 12.319 11.113 14.942 13.332 10.782 11.948 8.8318 12.062 8.86 9.9121 16.658 10.33199 16.83746 12.55986 10.70047 12.34909 16.03122 4.66369 5.634714 9.565563 4.242641 7.331439 8.732125 7.889867 7.53326 7.228416 9.874209 9.460444 10.87428 11.74734 8.336666 13.93736 15.87451 15.05822 10.46422 14.47411 20.43893 11.42366 12.15525 11.29159 14.55163 13.55544 11.0227 16.91892 14.33527 14.34399 13.24764KP 35-50 Correlated 17.875 22.578 28.974 20.261 18.908 23.463 31.765 29.047 22.989 37.306 33.563 34.011 31.898 32.284 37.45 37.289 28.749 32.856 30.578 38.266 15.992 29.492 10.571 17.741 21.184 23.638 19.17 23.189 21.639 28.853 34.835 28.196 35.214 22.175 30.976 29.419 34.706 36.301 31.824 27.722 26.505 30.058 35.135 36.083 39.56 26.239 35.812 25.588 35.093 38.311 12.659 14.543 21.5 20.482 28.134 27.023 24.14 22.633 21.794 32.772 23.911 24.393 29.983 23.775 27.97767 27.70379 35.45772 35.90961 32.21025 36.06591 5.612486 19.94367 13.08625 17.67767 15.37043 17.35655 18.25514 19.09843 33.84154 32.61518 21.31901 26.9583 27.04626 22.26544 30.55323 27.32215 36.07284 34.97856 27.89713 37.86819 30.08322 32.48846 23.52658 33.5522 29.65637 29.27456 32.1014 32.87856 34.48188 32.70321KP 50-65 Correlated 25.402 28.805 45.484 31.949 48.505 49.048 38.122 57.702 40.221 45.075 53.512 48.309 76.351 53.94 57.177 49.732 52.785 68.984 67.899 55.94 18.453 32.715 26.334 25.952 48.466 49.117 26.353 37.45 33.162 44.839 37.583 60.98 56.58 35.965 47.281 47.893 52.259 68.283 51.643 61.555 56.069 64.44 64.533 63.846 70.502 41.731 44.872 42.172 59.233 65.605 38.115 34.051 46.597 42.524 51.858 45.809 42.67 55.841 49.832 48.088 61.681 64.432 68.24 48.049 60.1789 57.94394 59.88739 65.22653 74.77633 70.94012 22.61637 22.33831 25.91332 29.78255 40.9695 56.87047 32.32646 49.88487 27.69476 53.60504 43.75786 49.35585 52.90085 33.70089 49.22906 50.36616 60.73302 73.59687 52.1656 70.54608 47.35504 66.68958 65.63917 61.37182 72.11623 46.87217 43.09872 38.68462 66.33061 70.03571KP 65-75 Correlated 39.402 51.549 56.013 53.033 76.358 80.391 53.589 75.809 74.838 77.624 77.042 89.206 106.22 84.476 108.12 100.02 91.107 99.743 100.59 111.32 32.175 44.037 42.098 62.813 64.85 61.012 43.032 61.99 51.976 91.221 63.73 74.547 100.54 63.47 85.279 69.549 83.338 90.374 68.9 86.503 74.347 102.52 87.882 107.84 87.165 63.936 72.784 76.758 110.51 83.696 41.325 64.523 61.927 55.635 69.192 66.616 53.856 90.227 86.888 97.261 77.978 81.788 92.639 85.14 97.8647 95.82145 109.3892 102.4536 87.28545 103.4444 40.68169 41.85093 45.57686 39.06725 64.06052 68.23672 44.89432 66.11165 55.05225 68.30447 80.04061 86.21195 90.63802 63.26531 85.54239 78.21445 97.24711 106.7872 73.96283 88.67497 87.52999 97.09531 97.40893 114.777 90.31334 60.36969 64.08003 75.48344 85.04411 87.64987KP 75+ Correlated 98.584 103.01 108.66 125.86 122.37 137.81 102.87 123.47 137.3 143.1 133.23 154.02 156.6 165.18 149 172.49 169.02 168.02 171.33 171 101.67 97.514 92.853 95.397 108.46 124.97 79.58 106.35 112.51 139.15 129.75 121.96 133.13 133 132.61 154.89 154.69 162.26 129.64 147.75 141.19 155.17 147.56 167.59 138.27 109.36 143.19 132.14 161.38 147.86 100.94 102.11 119.25 122.81 125.29 137.17 97.903 129.15 135.13 127.16 140.56 143.66 163.69 147.68 147.7786 166.5998 177.721 176.7979 154.1923 185.0925 97.56664 87.09908 108.1215 96.29512 109.5981 112.651 99.04671 110.8873 122.7284 123.5121 148.1604 140.7427 134.4489 130.0875 137.6408 145.8749 153.4837 157.1743 139.858 144.216 140.7924 160.6168 154.6294 177.7147 144.307 116.4023 137.3772 137.933 163.0659 146.5938KP Total Correlated 58.254 63.004 58.727 55.629 86.828 86.145 63.378 70.857 79.398 68.557 89.424 77.643 96.863 85.316 96.552 98.656 90.402 93.452 93.577 104.65 28.708 43.276 52.428 41.744 64.403 63.033 50.451 56.094 46.025 65.812 70.199 85.165 74.485 63.583 88.055 70.001 92.963 95.788 83.642 85.716 74.051 86.121 89.574 83.873 95.292 60.563 59.365 73.475 92.695 90.874 48.999 63.332 66.923 66.063 77.609 79.189 75.481 83.214 87.237 77.791 79.076 71.42 95.118 80.683 93.20294 95.75204 100.7771 103.5828 92.82765 114.9368 34.65083 41.81893 53.88183 36.45416 50.14377 68.1743 49.03585 60.12703 61.35043 68.84244 59.82082 78.37868 85.20943 66.49386 69.80894 86.3121 83.55231 103.1698 70.09456 97.42013 84.62645 102.4905 92.6492 109.0508 94.61112 63.32954 85.06665 72.43039 81.32232 86.07897NDR 20-34 Correlated 13.454 16.031 14 8.5147 9.8489 11.18 14.142 12.748 17.678 25.942 14.983 15.264 21.783 16.263 14.714 15.508 13.038 19.313 16 16.447 6.7082 9.0554 18.028 8.6023 9 10.77 12.349 13.509 22.727 20.591 24.413 20.94 23.927 18.398 20.1 13.657 20.261 22.472 20.555 18.125 18.398 23.717 17.493 21.633 23.77 21.92 27.973 24.839 23.717 24.166 4.9497 12.349 11.402 9.434 9.4868 13.73 15 14.577 14.916 15.811 19.455 19.558 14.983 9.9247 13.58308 17.10263 16.27882 12.74755 14.86607 16.86713 5.700877 13.15295 7.648529 10.63015 12.16553 7.071068 12.74755 13 24.78911 19.03943 28.50439 22.82542 17.02939 19.14419 23.71708 16.32483 21.09502 23.02173 24.18677 14.31782 21.93171 25.26856 18.78829 23.02173 23.71708 29 26.23928 33.35416 32.44996 29.15476NDR 35-50 Correlated 10.442 20.216 8.9221 8.148 17.228 9.1002 16.37 21.232 25.223 27.557 22.222 32.487 27.447 22.931 23.032 22.845 20.679 22.957 25.313 25.794 10.235 20.483 16.039 14.161 14.246 9.2212 16.159 21.902 22.275 23.944 23.594 23.256 22.709 22.275 27.783 18.886 16.739 19.71 23.838 26.145 34.952 37.598 25.323 40.968 36.358 35.683 30.801 38.51 28.38 35.347 6.6681 16.489 15.544 8.2439 18.799 15.769 14.556 17.541 23.674 18.682 24.582 31.422 29.957 15.228 19.02354 23.29101 21.27638 20.15565 26.73483 16.10994 4.731833 16.10994 11.85163 6.554559 16.56467 11.18491 16.61199 20.37232 32.25646 26.1624 18.30607 27.4247 27.31643 20.82513 23.94421 11.97169 27.54931 19.72403 26.64386 25.65504 20.11858 25.9871 31.65401 32.0264 31.54434 27.18016 33.88392 35.39038 41.5226 34.13692NDR 50-65 Correlated 18.1 23.483 23.262 23.262 32.317 34.464 26.006 37.451 46.585 42.975 46.459 44.415 53.653 46.998 53.947 42.71 42.29 48.774 37.483 62.564 11.037 22.693 17.777 12.05 34.79 25.198 20.039 28.282 26.087 51.19 29.351 30.674 49.154 41.173 35.238 24.119 37.546 39.761 29.537 45.666 51.764 63.194 53.289 59.015 47.182 41.065 36.002 37.115 45.421 51.149 15.366 20.638 18.216 18.854 32.55 26.695 22.742 39.755 57.8 49.047 45.169 56.31 57.852 39.928 43.17372 48.40477 46.40438 41.53473 39.58593 48.35587 15.38629 19.83225 15.80791 12.48543 35.76633 29.65323 16.56013 35.7974 29.32081 38.6953 38.54117 49.56767 38.8159 31.17547 33.09323 34.24228 44.54371 42.96494 36.58795 39.74295 49.92244 44.58576 58.36651 63.36111 54.17141 32.14912 49.41759 52.68618 50.68659 37.0616NDR 65-75 Correlated 30.739 38.742 36.861 33.376 54.221 65.149 41.529 60.117 68.143 55.219 73.731 45.946 66.876 62.392 71.446 60.684 79.589 85.849 72.119 68.782 2.0519 8.6906 7.4093 8.571 36.449 38.5 15.472 38.368 41.616 38.853 31.953 50.141 55.302 56.283 35.141 49.548 48.385 68.328 44.938 73.657 72.423 70.269 79.649 88.025 82.058 48.539 52.298 45.119 56.816 65.867 46.825 38.317 43.372 37.459 57.615 38.803 32.593 46.837 61.345 62.324 58.552 71.014 76.191 68.029 94.98304 66.75265 59.49637 72.82761 70.94395 72.27347 11.26189 6.236513 26.93812 10.43686 37.65974 44.38516 10.39664 51.10998 42.92494 37.72084 32.84363 50.59613 71.34428 34.78123 46.14677 46.8254 62.21566 56.17496 43.87724 66.51535 82.86804 67.34248 73.13716 80.27642 82.44501 37.63374 56.28611 43.76421 58.42628 69.19773NDR 75+ Correlated 41.49 36.603 32.645 42.715 33.528 64.677 16.693 52.257 60.049 49.204 49.07 51.829 63.361 86.488 75.02 92.424 74.314 87.673 99.404 82.202 47.826 31.142 45.638 28.134 35.718 61.289 40.351 51.76 27.889 24.055 35.609 38.613 45.183 57.354 70.181 63.486 60.513 68.362 58.075 60.946 65.417 57.752 70.12 88.879 71.535 42.49 42.376 56.865 61.256 62.474 48.924 34.49 40.679 36.884 30.197 45.806 37.568 40.184 72.913 47.369 55.563 42.706 59.942 79.178 73.99142 89.56537 87.87041 99.79002 73.28635 87.00126 32.96876 44.16483 34.4591 32.57261 46.38246 55.299 34.75429 58.73104 38.77103 34.22306 36.78964 29.27903 48.54059 50.24512 45.97103 55.42412 63.65408 56.5998 43.50787 70.78665 72.79477 75.69027 76.5083 88.97559 83.17453 45.11608 48.07701 50.60993 36.94431 53.51159NDR Total Correlated 50.881 47.645 58.555 52.113 49.167 53.899 43.178 63.269 67.914 61.857 56.839 57.874 61.149 66.554 58.521 65.821 61.565 77.245 60.089 82.504 6.906 12.733 16.336 17.881 31.395 34.356 17.428 53.278 41.603 46.131 41.357 53.521 56.494 40.898 45.91 41.817 49.504 62.356 57.915 60.595 73.559 65.753 78.17 78.969 69.313 51.424 46.264 60.265 63.131 60.095 47.274 52.425 44.254 42.32 50.64 46.516 50.755 62.631 65.766 56.097 59.695 76.486 68.701 72.954 70.83605 75.77371 85.18445 64.75849 66.53489 84.83685 11.61501 10.95883 23.06102 20.33318 36.72741 33.50389 20.22631 42.75721 37.449 36.41444 40.94518 56.11752 59.3596 51.42449 41.31894 47.82216 51.42806 67.12578 42.69651 67.79355 85.75565 79.18051 66.61309 86.07532 80.89447 60.66686 50.37258 58.65354 56.74934 64.7297AHEAD Control Correlated 19.255 23.089 29.387 26.095 26.337 41.288 26.169 29.743 36.53 32.877 52.842 55.377 61.801 41.529 56.257 60.382 61.546 76.639 57.965 61.486 26.899 30.162 24.395 31.875 32.729 36.513 24.037 40.437 20.637 39.068 32.214 36.213 47.521 23.686 49.123 53.733 37.439 58.914 47.909 52.111 40.23 49.278 42.632 66.147 44.236 28.377 35.574 28.623 50.039 44.788 25.334 17.695 30.872 25.966 28.164 36.546 27.473 34.59 35.636 26.299 43.432 47.481 58.698 42.428 60.03597 53.06528 65.6479 59.14535 37.47514 67.85203 35.26464 23.80807 27.20027 24.26052 32.08737 38.43941 25.21126 30.54505 22.63183 28.02459 26.2872 34.93868 35.3136 25.34645 34.30483 37.18064 42.5281 48.54957 29.89905 52.48586 31.02699 43.42837 38.31558 54.58723 46.10875 25.18063 28.92475 26.06138 46.63666 41.60066AHEAD Intervention Correlated 21.386 25.176 24.036 24.89 25.519 44.201 21.01 33.31 31.942 42.707 44.343 43.699 50.446 40.774 50.805 43.47 50.981 67.811 48.004 78.952 22.335 21.039 21.723 17.624 24.585 37.459 27.303 35.56 16.107 36.466 41.114 37.062 47.043 34.463 46.403 40.66 56.375 73.7 44.265 65.47 44.707 61.54 53.194 65.144 49.987 30.168 36.932 30.367 52.489 42.558 26.76 26.788 18.934 20.598 24.617 27.371 19.289 33.571 26.976 30.91 38.925 41.255 48.716 48.496 51.51591 57.83976 47.19153 60.34054 49.93546 60.84268 28.0176 21.89322 19.75981 23.62955 30.08597 36.68516 26.09191 31.82735 20.11383 30.72752 34.83324 29.25671 57.08976 30.08294 41.31217 36.9201 44.64726 45.36598 43.73596 44.08342 35.93888 33.46684 50.8603 60.19333 39.81571 28.74976 29.59162 42.74911 36.98874 39.30617AHEAD Full Correlated 25.862 26.582 19.365 23.507 30.617 39.55 20.882 25.341 35.955 36.707 42.724 47.692 60.642 68.793 55.574 69.267 60.195 67.83 65.266 60.276 27.019 27.456 26.207 27.648 32.969 41.14 24.225 36.541 24.75 35.403 37.167 51.549 40.539 26.968 40.527 31.192 45.455 62.596 34.337 49.599 49.349 66.562 60.388 66.857 44.442 27.056 36.879 30.303 48.635 45.174 23.67 25.828 22.548 27.941 26.259 38.85 21.752 34.043 29.21 32.129 42.577 37.738 44.635 54.14 53.40604 46.13002 62.01177 53.78968 51.64714 54.47643 29.10672 22.09043 23.07083 23.60879 29.76152 30.3755 20.28 31.35945 22.7244 22.69462 39.90384 27.51362 40.01311 29.45684 27.77101 35.79017 41.34391 46.36474 35.50261 48.46416 27.55285 41.67373 37.92269 61.54413 46.76105 22.68557 29.70695 36.61825 44.41414 43.14444ADDITION Routine Correlated 9.1378 18.822 15.898 17.117 34.369 27.29 28.944 34.547 35.605 33.121 43.761 45.516 49.767 32.932 31.777 26.024 33.697 45.492 40.515 46.182 16.163 26.201 16.485 18.901 28.328 25.367 22.028 30.525 18.18 30.145 36.555 45.006 35.662 17.073 29.043 27.744 33.697 24.485 29.987 36.39 48.094 38.604 40.237 48.536 51.288 34.205 42.62 27.991 37.279 33.493 13.019 17.671 13.739 8.0623 21.737 23.404 18.021 26.134 28.182 26.22 26.215 27.749 39.287 18.2 26.73481 22.95648 35.80154 28.44732 25.89401 28.33284 5.809475 10.27132 15.32155 13.05756 23.90607 20.83867 13.90144 29.03016 18.56071 23.08138 22.46664 28.6007 28.67054 13.70219 24.44381 21.45926 27.95979 35.50352 22.62189 31.64253 31.54362 33.39536 36.08324 40.74923 31.99609 22.17544 19.42292 23.67488 31.13679 29.97082ADDITION Intensive Correlated 16.109 26.763 18.145 20.779 31.8 38.115 35.103 36.142 41.839 44.3 50.19 42.267 52.913 42.488 46.341 42.039 35.075 45.445 42.573 50.085 14.08 21.29 22.567 17.937 31.472 30.737 22.825 34.106 20.451 30.224 35.518 39.906 38.929 24.92 30.434 34.735 43.789 31.209 33.96 40.268 44.167 44.511 55.547 58.919 56.708 32.051 41.776 29.572 36.858 41.079 11.769 17.219 13.946 18.405 30.112 20.056 16.591 32.473 31.157 30.52 35.749 40.441 35.007 26.618 33.98897 30.11229 32.1014 33.31666 30.83018 45.48077 12.02082 15.41914 14.94992 11.82159 20.56696 19.24838 17.53568 18.80824 24.4387 20.95233 27.96873 30.69202 28.68362 20.97022 25.5832 24.59167 25.44111 26.40076 22.25983 29.97499 36.09016 39.55692 34.78865 42.62335 38.41224 31.42053 24.89478 30.17449 30.89094 36.68106ADDITION Full Correlated 19.119 26.809 18.887 23.206 32.286 29.935 22.553 40.438 41.57 40.964 43.546 47.787 56.75 34.254 35.015 50.421 35.276 46.651 42.261 49.031 18.862 23.399 15.043 18.672 33.469 28.893 24.176 36.2 29.508 29.656 29.526 35.828 40.837 25.158 26.202 29.769 36.377 32.866 28.606 32.228 38.671 46.193 48.545 57.139 46.099 35.047 34.944 39.425 38.076 47.883 12.763 15.059 13.926 11.766 18.309 21.523 17.813 27.355 33.959 35.208 26.974 34.323 35.251 25.795 33.2934 21.40087 35.80205 30.31716 28.57745 33.75606 8.322346 12.51285 14.75296 14.40318 25.70739 27.27283 19.69282 29.78579 25.29611 25.03795 24.94678 30.72467 24.20451 20.7312 26.34269 15.33425 21.91895 27.47884 26.90512 26.15859 33.29674 39.53337 39.80173 32.04581 42.87103 26.31957 18.26741 22.58661 43.14238 34.07839

Method_A1c 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1Method_BMI 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1Method_BP 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1Method_Lipids 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1Method_Smoke 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1Method_MI 1 1 1 1 1 1 1 1 2 2 2 2 2 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 5 5 5 5 5 6 6 6 6 6 6 6 7 7 7 7 7 8 8 8 8 8 1 1 1 1 1 1 1 1 2 2 2 2 2 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 5 5 5 5 5 6 6 6 6 6 6 6 7 7 7 7 7 8 8 8 8 8Method_Stroke 1 2 3 4 5 6 7 8 1 2 3 4 6 1 2 3 4 5 7 8 1 2 3 4 5 6 7 8 1 3 4 5 6 1 2 4 5 6 7 8 1 3 4 6 7 1 3 4 6 8 1 2 3 4 5 6 7 8 1 2 3 4 6 1 2 3 4 5 7 8 1 2 3 4 5 6 7 8 1 3 4 5 6 1 2 4 5 6 7 8 1 3 4 6 7 1 3 4 6 8Method_DeathCHD 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1Method_DeathStroke 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1Method_TimeImprove 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5

Date Correction

Raw Models BioMarker Correction

Date+BioMarker Correction

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Version 22 - MIST_RefModel_2014_04_29_MATRIX_TraceBack.zip

Page 16: The reference model for disease progression uses MIST to find data fitness by Jacob Barhak PyData SV 2014

Jacob Barhak

This Modeling Technology Opens Possibilities

• The Reference Model for Disease Progression – Participating in the Mount Hood Challenge 2014 – Non diabetic populations?

• Population Generation - Unexplored Potential:– Planning Recruitment Efforts?• Clinical Trials?• Other Recruitment Efforts?

– Other population modeling?

Page 17: The reference model for disease progression uses MIST to find data fitness by Jacob Barhak PyData SV 2014

Jacob Barhak

Acknowledgments• Deanna J.M. Isaman - who is the spirit behind the great ideas. She taught me my first steps in disease modeling

• Morton Brown & William H. Herman – for guidance, critical feedback, and growth environment

• Aaron Garrett – for his responsiveness and help with starting with Inspyred – he saved me at least a months work if not two by sending me solution code within one day.

• Continuum Analytics and specifically:– Benjamin Zeitler for creating the cloud AMI– Ilan Schnell for his work on Anaconda.

• All those who developed free software used and supported it: including Python, Anaconda, Spyder, numpy, SciPy, nose, winpdb, Star Cluster, Ubuntu, Sun Grid Engine

• The legacy IEST modeling framework was supported by the Biostatistics and Economic Modeling Core of the MDRTC (P60DK020572) and by the Methods and Measurement Core of the MCDTR (P30DK092926), both funded by the National Institute of Diabetes and Digestive and Kidney Diseases. The modeling framework was initially defined as GPL and was funded by Chronic Disease Modeling for Clinical Research Innovations grant (R21DK075077) from the same institute. MIST is based on IEST.

• The Reference Model and MIST were developed independently without financial support

Page 18: The reference model for disease progression uses MIST to find data fitness by Jacob Barhak PyData SV 2014

Jacob Barhak

Questions?

MIST Jacob Barhakhttps://github.com/Jacob-Barhak/MIST http://sites.google.com/site/jacobbarhak/

https://github.com/Jacob-Barhak/MIST
http://sites.google.com/site/jacobbarhak/
http://sites.google.com/site/jacobbarhak/

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