The R&D landscape in the State of São Paulo,...

Carlos H. de Brito Cruz

Science Director

FAPESP

Shell-FAPESP Workshop on Offshore R&D, 20200303

sp-r-and-d-landscape-chbc20190528.pptx 120190528

The R&D landscape in the State of São Paulo, Brazil

Outline

• R&D in the State of São Paulo, Brazil

– The São Paulo Research Foundation, FAPESP

• A bird’s eye view on R&D results in São Paulo

– The challenge of obtaining more impact from research in three dimensions: Scientific, Social, Economic

• Research collaboration strategy

– Research collaboration across geographies and institutions

– University-Industry joint R&D

– Start-ups and Small Business R&D

20190528 2sp-r-and-d-landscape-chbc20190528.pptx

State of São Paulo, Brasil


42 million people

32% of Brazil’s GDP

45% of Brazilian Science

7,319 PhDs graduated in 2017

39% of the PhDs graduated in Brazil

12% of State budget to HE and R&D

1.3% GDP for R&D (2017)

http://www.guianet.com.br/guiacidades/

http://www.guianet.com.br/guiacidades/

São Paulo: 69,600 researchers, 151 institutions, 15,000 innovative companies


FAPESP: São Paulo Research Foundation

• Mission: support research in all fields• Funded by the State of SP: 1% of all tax revenues• All proposals are peer reviewed (26,000 in 2018)

– Time for decision ~ 70 days; 41% success rate

• Expenditures: R$ 1.266 billion in 2019– Fellowships

• In Brazil: 2,500 SI, 1,150 MSc, 2,400 DrSc, 1,700 Post-docs• Abroad: 1,200 per year

– Academic R&D• 17 Centers (11-yrs dur.), 400 Thematic (5-yrs), 300 Young Investigators (5-yrs), 2,800 Regular (2-

yrs)

– University-Industry Joint R&D: Microsoft, Vale, Petrobrás, Embraer, Boeing, etc.• 14 Engineering Res. Centers: 10 years joint grants FAPESP/Industry – PCBA, GSK, BG/Shell,

Embrapa, …

– Small business R&D (PIPE): 1,500 SBE’s (247 contracts in 2019, many start-ups)


BASIC, APPLIED, ACADEMIC, BUSINESS RESEARCH


Researchers in São Paulo, Brazil publish more than any Latin American country


0

5000

10000

15000

20000

25000

30000Number of articles per year (Clarivate, Incites)

SAO PAULO; BRAZIL MEXICO ARGENTINA CHILE COLOMBIA PERU VENEZUELA

Higher productivity sugarcane:84 → 148 → 212 → 381 ton/Ha??


1980-2013: change in energy sources in the State of São Paulo, Brazil


Oil and oil products

Hydroelectricity

Sugar cane

Other

Natural gas

14%

62%

32%

38%

State of São Paulo

• 42 million people

• 32% of Brazil’s GDP

• 55% of Brazilian

ethanol production

1980 – 2013

• Oil down from 62% to 38%

• Cane up from 14% to 32%

Source: Balanço Energético SP, 2008-2014 (values from 1980-1990 interpolated for visualization)

SIRIUS, Brazilian Synchrotron Light Source:LINAC and Booster inaugurated on Nov , 2018


Unicamp: 821 start-ups; 717 active; 31,143 jobs, R$ 7.9 billion in revenues (2019)

benchmarking-20200209.pptx; © C.H. Brito Cruz e Fapesp 123/4/2020

USP: 1,154 companies, 6 unicorns, R$ 60 billion income (2018)


Embraer-FAPESP: R&D to build an innovative jet


Computational Fluid Dynamics (CFD)

modelling and tests

R&D co-funded by FAPESP, several

universities

University-Business co-authorship in Brazil –exponential growth

benchmarking-20200209.pptx; © C.H. Brito Cruz e Fapesp 153/4/2020

0

200

400

600

800

1000

1200

1400

1600

WoS items with co-authorship between universities in Brazil and companies

Escala logaritimica: +14% por ano

Engineering Research Centers at FAPESP: Advanced Joint University/Industry Research

• A long-term plan for Advanced Research

• Center is hosted in a university/institute, – Center Director is a professor/researcher

– Adjunct Director is a researcher from the company as a visiting professor at the university

– Other company researchers participate as visiting professors

• Up to 10-years contract, w. reviews on years 3, 5, 7

• Cost sharing: FAPESP: Industry: University ̴ 1:1:2– US$ 0.5 – 4 million per year from FAPESP and Company, plus labor

and infrastructure costs by university


Engineering Research Centers: R$ 1,02 billion in contracts; FAPESP+Business+Host (Univ/Res Inst)

1. Peugeot-Citroen/Unicamp: Biofuel Engines Engineering Research Center2. 10+ Pharmas/SGC/Unicamp/Oxford/Toronto/N. Carolina: Structural Genomics Center @ Unicamp3. GSK/I. Butantan: Engineering Research Center on Target Discovery4. GSK/UFSCAR: Engineering Research Center on Sustainable Chemistry5. Shell (British Gas)/USP: Engineering Research Center on Natural Gas6. Natura/USP: Applied Research Center on Well-being and Human Behavior7. Embrapa/Unicamp: Agriculture, Gene Editing, Climate Change8. Shell (BG)/Unicamp/USP/IPEN: New Energy

1. Shell (BG)/Unicamp: Dense Energy Carriers2. Shell (BG)/USP: Computational Materials Sciences3. Shell (BG)/Unicamp: Advanced Energy Storage4. Shell (BG)/IPEN: Methane2Products

9. Equinor/Unicamp: Oil Reservoirs10. Koppert/USP: Biological Control11. Usina S. Martinho/Unesp: Biological Control for Sugarcane12. IBM/USP: Artificial Intelligence13. Call open for 2 more centers on IA


An internationally connected R&D hub in São Paulo, Brazil

• Good supply of qualified researchers

• Stably funded universities and research agency

• Intense, and growing, industrial R&D

– University-Industry R&D collaboration

– Lively start-up scene


CONCLUSION


FT, CB Insights: São Paulo as a Tech-hub


Colaborações em Pesquisa - China


FAPESP-NIH-Butantan: Tetravalent Dengue vaccine


Colaborações em Pesquisa - China


São Paulo, Brazil: University-Business co-authorship in scientific articles


0,00%

0,60%

1,20%

1,80%

2,40%

3,00%

0

120

240

360

480

600

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Main partners

Petrobras

Novartis

Pfizer

Roche

GSK

IBM

Vale/ITV

Merck

Eletrobras

AstraZeneca

Fibria

Westat

Janssen

Embraer

Bayer

Monsanto

Agilent

Braskem

Boehringer Ingelheim

Sanofi

A growing list of high impact research results……


SOAR: Southern Observatory for Astrophysical Research


J.B. Haislip et al., “A photometric redshift of z = 6.39 0.12 for GRB 050904”,

Nature 440, 181-183 (9 March 2006).

Infrared afterglow observation after a GRB -unveils the explosion which happened 13 billion years ago.These results demonstrated that GRBs can be used to trace the star formation, metallicity, and reionization histories of the early Universe.

USP, UFRGS, UNC Ch.Hill

Fapesp, CNPq, NSF,...

Starting 2014:

http://www.nasa.gov/images/content/133245main_sburst_Dana_still.jpg

http://www.nasa.gov/images/content/133245main_sburst_Dana_still.jpg

Personalized medicine


FAPESP’s Center for Cellular Therapyhosted at USP’s Hemocenter, Ribeirão Preto


Monoclonal antibodies: Recepta – Mersanaagreement


Advanced Molecular Biology for Agriculture and Health


Brazil Energy Supply - 2016


0

10

20

30

40

50

60

70

NON-RENEWABLEENERGY

RENEWABLE ENERGY

Brazil 2016, PES

Starting with a MSc dissertation on “Cooperative multirobot localization…”..


…to an idea….+ funding from FAPESP …+IP protection….


…ao produto e empresa


Hoobox is at J&J Innovation Labs, Houston


Destruir tumor cerebral com virus Zika sem afetar as células boas


Usar vírus Zika para acabar

com o tumor sem afetar as

células normais. Super

resultado de Oswaldo

Okamoto, Carolini Kaid,

Mayana Zatz e equipe da

USP com apoio da FAPESP.

https://youtu.be/u_uoaa2Ua

ME

https://youtu.be/u_uoaa2UaME

PIPE, FAPESP: Aumento no emprego


http://revistapesquisa.fapesp.br/2017/12/28/o-maior-programa-de-estimulo-a-inovacao/

O impacto no nível de emprego

das empresas envolvidas é

expressivo: • aumento de 40% nos

recursos humanos

(contratados, terceirizados e

bolsistas)

• aumento de quase 30% no

pessoal contratado

diretamente que levou à

ampliação, até um ano após

o encerramento do projeto• de 60% do pessoal de

nível superior

• de mais de 90% do pessoal

com pós-graduação

Start-ups created by students and faculty at Unicamp, 1974-2015


Engineering Research Centers: R$ 1,02 billion in contracts; FAPESP+Business+Host (Univ/Res Inst)


Themes Company/Univ/Res. Ins.FAPESP

(est 10-yr)Company(est 10-yr)

Hosts(est 10-yr)

Biofuel automobile engines Peugeot-Citroen+Unicamp and others R$ 11 M R$ 8 M R$ 15 M

Green Chemistry GSK+Ufscar e outras R$ 12 M R$ 57M R$ 42M

Target discovery GSK+Inst. Butantan R$ 26 M R$ 23M R$ 67M

Natural Gas Shell/BG+Poli, USP and others R$ 46 M R$ 58M R$ 42M

Human well-being Natura+Inst. Psicologia, USP+ R$ 9 M R$ 10M R$ 22M

Agriculture,Climate Change,Gene Editing EMBRAPA+Unicamp R$ 25 M R$ 33M R$ 45M

New Energy (1 hub, 4 spokes) Shell/BG+Unicamp, IPEN, USP-SC R$ 42 M R$ 65 M R$ 158 M

Oil and Gas Reservoirs Statoil/Equinor+Unicamp and others R$ 34 M R$ 26 M R$ 125 M

Biological Control in Agriculture Koppert R$ 6,9M R$ 5M R$ 6,3M

Biological Control for Sugarcane Usina São Martinho

Artificial Intelligence IBM

Digital Technologies for Oil and Gas Petrobrás

Aerodynamics, Computational Fuidodynamics


Brazil: State R&D expenditures, 2015


Source: Indicadores C&T, MCTI

8 x

29 x

BRIC and OECD countries: % renewables in Total Primary Energy Supply, by type


From: IEA, Renewables Information 2017, Part II, Table 3 p. II.5

Brasil, São Paulo, Brasil fora de São Paulo


Brasil São Paulo Brasil sem São Paulo

Basic research applied to real problems


The R&D landscape in the State of São Paulo,...

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