The potential regeneration of transected hair follicles in...
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The potential regeneration of transected hair follicles in the
donor area using FUE
Georgios Zontos MD, PhDDiplomate ABHRS
Medical Director of Harklinikken, Denmark- University of Patras, School of Medicine, Patra, Greece
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DISCLOSURES:
The Speaker has no relevant financial relationship
or conflict of interest to declare.
Georgios Zontos MD, PhD, Diplomate ABHRS 2
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Background
➢ Devroye found that only
60% of transected hair
follicles regrow
Georgios Zontos MD, PhD, Diplomate ABHRS
➢ regrowth is unpredictable
but is more probable if
transection occurs at the
upper part of the follicle
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➢ What happens to transected
hair follicles in the donor
area?
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Objectives
The purpose of this study is
-to precisely quantify the regrowth rate of transected
hair follicles by using advanced image processing
techniques.
-to investigate under which conditions a potential
regeneration of hair follicles will likely occur
Georgios Zontos MD, PhD, Diplomate ABHRS4
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Materials and Methods
▪ 3 patients
▪ 6 areas of interest in the donor
region were permanently marked
by a tattoo
▪ A 0.6 sharp circular punch was
used to deliberately increase the
transection rate while harvesting
within the marked areas
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All the FUs were precisely
mapped before and after the
harvesting process while the
extracted grafts were
photographed and observed
under a stereoscope
Georgios Zontos MD, PhD, Diplomate ABHRS
Materials and Methods
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A proprietary image processing system was
adapted to compare the micro-photographs
taken of each study square
Micro photographs were taken of each study
square before and immediately after the
harvesting process and 9 months later.
Georgios Zontos MD, PhD, Diplomate ABHRS
Materials and Methods
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Georgios Zontos MD, PhD, Diplomate ABHRS
Comparison of micro-photographs before and immediately after the harvesting process
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Comparison of micro-photographs before and 9 months after the harvesting process
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What was recorded ?
➢ The initial number of FUs /hairs
➢ Number of harvested grafts/hairs
➢ Number of remaining FUs /hairs
➢ Number of intact extracted hair follicles
➢ Number of transected hair follicles
➢ Number of regenerated hair follicles over the study period
What was measured ?
- The percentage of regeneration of transected hair follicles in
each study square.
- Any evidence of regeneration of hair growth associated with
intact extracted hair follicles .Georgios Zontos MD, PhD, Diplomate ABHRS 10
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Protocol A -Statistical analysis of the results
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Protocol B:The correlation between the location of transection and regeneration of the remaining part of the follicles
From 3 new patients, 60 FUs
were transected transversally,
leaving less than 50% of the
FU length. Georgios Zontos MD, PhD, Diplomate ABHRS 12
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Protocol B -Statistical Analysis of the results
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The Regeneration Percentage in Protocol B decreased by 21.5%
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0.00%
10.00%
20.00%
30.00%
40.00%
50.00%
60.00%
70.00%
80.00%
90.00%
Regeneration Percentage A Regeneration Percentage B
84.91%
66.67%
Comparison of Regeneration Percentage in both Protocols
A B
The lower the transection level occurs, the lower the regrowth rate is
Georgios Zontos MD, PhD, Diplomate ABHRS
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Conclusions
Georgios Zontos MD, PhD, Diplomate ABHRS 15
- There is a high degree of accordance with
Devroye in Protocol B.
- Transecting FUs ,is likely to influence their
vitality.
- if transection occurs at the upper third part of the
hair follicle the regeneration rate is 100%
- Any damage at the level of the hair bulge ,or
absence of it, may diminish the regeneration
capability of the remaining transected hair follicle
- A high transection rate potentially affects the
harvesting capacity of the donor area especially
for a novice surgeon
- There is no evidence of regrowth of intact
extracted hair follicles.
Photo Courtesy:
Hair Transplantation,
Walter P. Unger, Ronald Shapiro
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The take - home message
- The potential regeneration of transected
hair follicles varies depending on where
the location of transection has occurred
during the FUE process.
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