The PATCHED (Ptc) Gene
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Transcript of The PATCHED (Ptc) Gene
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The PATCHED (Ptc) The PATCHED (Ptc) GeneGene
Brendan McQuellonBrendan McQuellon
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What is PATCHWhat is PATCH
• Transmembrane surface receptor
• Binds ligands of Hedgehog(Hh) familyWeinberg, 2007
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Normal Ptc RoleNormal Ptc Role
• Controls cell fate by inhibiting Hh/Shh signaling
• Inhibits the transcription of Hh/Shh target genes
• Can regulate the cell cycle
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Shh/Ptc/Gli pathwayShh/Ptc/Gli pathway
Weinberg, 2007
http://www.armchairempire.com/images/feature-articles/Weekly-Top-10/pub-crawl/sonic-hedgehog.jpg
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Shh/Ptc/Gli pathwayShh/Ptc/Gli pathway
Weinberg, 2007
http://www.armchairempire.com/images/feature-articles/Weekly-Top-10/pub-crawl/sonic-hedgehog.jpg
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Sonic hedgehog and Patched Sonic hedgehog and Patched regulate neural developmentregulate neural development
http://scienceblogs.com/pharyngula/2007/03/basics_neurulation.phpwww.pressthebuttons.com/
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Sonic hedgehog and Patched Sonic hedgehog and Patched regulate neural developmentregulate neural development
http://scienceblogs.com/pharyngula/2007/03/basics_neurulation.phpwww.pressthebuttons.com/
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Sonic hedgehog and Patched Sonic hedgehog and Patched regulate neural developmentregulate neural development
http://scienceblogs.com/pharyngula/2007/03/basics_neurulation.php
www.pressthebuttons.com/
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Sonic hedgehog and Patched Sonic hedgehog and Patched regulate neural developmentregulate neural development
Goodrich et al, 2007 www.pressthebuttons.com/
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How KO’s were madeHow KO’s were made
Goodrich et al., 1997
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Heterozygous MiceHeterozygous Mice
Goodrich et at., 1997
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Heterozygous MiceHeterozygous Mice
Goodrich et at., 1997
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How does Ptc relate to cancer?How does Ptc relate to cancer?
• Gorlin Syndrome– Basal Cell Carcinomas
– Medulloblastomas
• Sporadic Instances
• Ionizing Radiation
http://www.medicalecology.org/images/atmosphere/skincancer1.gif
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How does Ptc relate to cancer?How does Ptc relate to cancer?
• Meningiomas, Breast and Esophageal carcinomas
• Shh/Ptc pathway hyperactive in many other cancers