Obstetric Difficult Airway Guidelines _ Difficult Airway Society 2015
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The Obstetric Difficult Airway Guidelines
Dr Mary Mushambi
Chair OAA/DAS obstetric difficult airway guidelines group
Consultant Anaesthetist
Leicester Royal Infirmary
The OAA/DAS Obstetric
Difficult Airway Guidelines
The purpose of my lecture
1. Discuss the work that the group has been doing
2. Highlight difficulties of formulating evidence based guidelines
3. Consultation process with you as members of OAA
Who we are
OAA/DAS combined group
Members
Mary Mushambi (Chair) - Leicester
Mansukh Popat - Oxford
Mike Kinsella - Bristol
Hilary Swales - Southampton
Audrey Quinn - Leeds
KK Ramaswamy - Northampton
Anoushka Winton - Trainee
representative
Steve Robson - Obstetrician
Malachy Columb - Statistician
The rest of this presentation
is on behalf of the work done
by the group
OAA/DAS obstetric
guidelines plan
Meeting since May 2012
Funding – DAS & OAA
Gather evidence/literature
search (>6,000 abstracts
and >600 papers)
Librarian support from
Leicester
Review of literature
Airway management in the pregnant woman
• Why airway is difficult
• How to assessment airway
• GA in the pregnant woman
- Pre-oxygenation
- Position
- RSI drugs
- Cricoid pressure
• Unanticipated difficult airway
• Anticipated difficult airway
• Teaching and training
What other guidelines are there
and what can we learn from them?
Plan A:
Initial tracheal
intubation plan
Plan B:
Secondary tracheal
intubation plan
Plan C:
Maintenance of
oxygenation, ventilation,
postponement of
surgery and awakening
Plan D:
Rescue techniques
for "can't intubate,
can't ventilate" situation
Direct laryngoscopy
failed intubation
succeed
succeed
succeed
Tracheal intubation
ILMATM or LMATM
failed oxygenation
failed oxygenation
Revert to face mask
Oxygenate & ventilate
LMATM
increasing hypoxaemia
or
fail
Cannula
cricothyroidotomy
Surgical
cricothyroidotomy
improved
oxygenationAwaken patient
Confirm - then
fibreoptic tracheal
intubation through
ILMATM or LMATM
Postpone surgery
Awaken patient
failed intubation
ASA
Italian
UK
Canadian
Success of the DAS unanticipated guidelines
- Step-by-step approach
- Simple flow charts
- Standardised teaching
- Standardised equipment
Plan A:
Initial tracheal
intubation plan
Plan B:
Secondary tracheal
intubation plan
Plan C:
Maintenance of
oxygenation, ventilation,
postponement of
surgery and awakening
Plan D:
Rescue techniques
for "can't intubate,
can't ventilate" situation
Direct laryngoscopy
failed intubation
succeed
succeed
succeed
Tracheal intubation
ILMATM or LMATM
failed oxygenation
failed oxygenation
Revert to face mask
Oxygenate & ventilate
LMATM
increasing hypoxaemia
or
fail
Cannula
cricothyroidotomy
Surgical
cricothyroidotomy
improved
oxygenationAwaken patient
Confirm - then
fibreoptic tracheal
intubation through
ILMATM or LMATM
Postpone surgery
Awaken patient
failed intubation
OAA guidelines group
Failed intubation guidelines
Selected GUIDELINE examples Dated
•Ipswich Hospital March 2008
•North Bristol NHS Trust August 2008
•Poole Hospital NHS Foundation Trust June 2009
•Queen Charlotte's Hospital London July 2010
•Sandwell & West Birmingham Hospitals NHS Trust March 2009
•Southampton University Hospitals NHS Trust March 2010
(These guidelines first displayed in September 2009)
Failed intubation guidelines
General/good points
Correct patient
position
Avoid 2nd dose of sux
and multiple attempts
Reducing cricoid
pressure
Easy to follow
flowcharts
Rescue airway
devices
Failed intubation guidelines
General/good points
Correct patient
position
Avoid 2nd dose of sux
and multiple attempts
Reducing cricoid
pressure
Easy to follow
flowcharts
Rescue airway
devices
Grading of decision
to continue/wake up
Call for help and
who to call for help
Continue with CS as
part of CPR
Follow up and
airway alerts
Failed intubation guidelines
Poor points
Multiple flow charts with no overall all-in-
one
Inserting Proseal LMA before sux wears
off
No mention or option about whether to
proceed or not
Not having a flow chart
Failed intubation guidelines
Unsure
Proceed to Proseal LMA before
attempting mask ventilation
All Guidelines mentioned continuing
with SV – Why not IPPV?
Nasal airway or blind nasal intubations
OAA/DAS obstetric guidelines
Brain storming
Questions to address
Brainstorming
Team briefing / ?
Include backup plan
Face mask ventilation
during RSI
Which laryngoscopes
Oxygen insufflation
during laryngoscopy
Max. no. of attempts
STP vs Propofol
Sux vs Roc and
sugammadex
Questions to address
Brainstorming
Team briefing / ? Include
backup plan
Face mask ventilation
during RSI
Which laryngoscopes
Oxygen insufflation
during laryngoscopy
Max. no. of attempts
STP vs Propofol
Sux vs Roc and
sugammadex
Supraglottic devices
How to continue with
GA
How to wake up/position
after FI
Experience of
anaesthetist vs continue
Technique for a known
difficult airway
Help / who and when
OAA/DAS obstetric guidelines plan
Background papers/projects
1. All reported cases/series of failed
intubations
2. Neonatal outcome
3. National OAA survey
4. Anticipated difficult airway
5. Final paper and algorithms
Case Series
Total no of GAs
Number of FI
Incidence of FI
Woken/continue
Airway devices
Morbidity/mortality
Year Case Series1978 Lyons
1979
1980 Glassenberg
1981
1982 Samsoon
1983
1984 Hawthorne McKeen
1985
1986
1987
1988 Saravankumar
1989
1990 Tsen
1991 Rocke Enohumah
1992 Ajmal
1993 Barnardo Nze
1994
1995
1996
1997 Shibli
1998
1999 Rahman
2000 Djabatey Palanisamy
2001 Tao
2002 Kan
2003 Bullough
2004 Teoh
2005 McDonnell
2006 Kirodian
2007
2008 Pujic Kessack Quinn Davies
2009 Keen NOAD 09
2010 NOAD 10
2011 NOAD 11
2012
Failed intubation series1
97
8
19
79
19
80
19
81
19
82
19
83
19
84
19
85
19
86
19
87
19
88
19
89
19
90
19
91
19
92
19
93
19
94
19
95
19
96
19
97
19
98
19
99
20
00
20
01
20
02
20
03
20
04
20
05
20
06
20
07
20
08
20
09
20
10
20
11
20
12
Lyons
Hawthorne
Glassenberg
Samsoon
McKeen
Saravankumar
Tsen
Rocke
Enohumah
Ajmal
Nze
Barnardo
Shibli
Rahman
Djabatey
Palanisamy
Tao
Kan
Bullough
Teoh
McDonnell
Kirodian
Davies
Quinn
Pujic
Kessack
Keen
NOAD 09
NOAD 10
NOAD 11
Number of reports 30
Number of Obs GAs 133,209
Total Failed intubations 330
Median FI rate
CS GAs 1:463
Total GAs 1:411
Case Reports
Urgency
BMI/Weight if available
Airway assessment
Number of attempts
Mask ventilation
Airway device
Cricoid pressure
Continue or wake up
SV or IPPV
Maternal/neonatal outcome
47 case reports
Main findings (case reports and series)
1. Failed intubation rates
2. Wake up or continue - majority continue - from 1990’s
3. Which SAD - majority in literature cLMA
4. 2nd generation LMA - orogastric tubes passed in majority
5. Cricoid pressure - Continued in 50% of cases
? With 2nd generation LMA
6. IPPV vs SV - not clear
7. Maintaining anaesthesia - majority used volatile
Main findings (case reports and series)
1. Failed intubation rates
2. Wake up or continue - majority continue - from 1990’s
3. Which SAD - majority in literature cLMA
4. 2nd generation LMA - orogastric tubes passed in majority
5. Cricoid pressure - Continued in 50% of cases
? With 2nd generation LMA
6. IPPV vs SV - not clear
7. Maintaining anaesthesia - majority used volatile
Number of failed intubations -
continued or woken up
Wake up vs continue data
F a ile d In tu b a t io n s P ro c e e d in g
Y e a r
Pro
po
rti
on
pro
ce
ed
ing
1 9 8 0 1 9 8 5 1 9 9 0 1 9 9 5 2 0 0 0 2 0 0 5 2 0 1 0
0 .0 0
0 .2 5
0 .5 0
0 .7 5
1 .0 0S lo p e 3 .4 % /y r (9 5 % C I 1 .4 -4 .9 )
P < 0 .0 0 0 1
Main findings (case reports and series)
1. Failed intubation rates
2. Wake up or continue - majority continue - from 1990’s
3. Which SAD - majority in literature cLMA
4. 2nd generation LMA - orogastric tubes passed in majority
5. Cricoid pressure - Continued in 50% of cases
? With 2nd generation LMA
6. IPPV vs SV - not clear
7. Maintaining anaesthesia - majority used volatile
Case reports – Airway device
cLMA - 23 cases
- 17 (74%) successful
- 12 cases completed on LMA
- 13 (76%) continued CP
2nd generation LMA
- All after 2004
- 8 cases
- All surgery continued
- 7/8 passed OG tubes
Rescue procedures for FI in UKOSS
Rescue Number of cases N = 57
_____________________________________________________
cLMA 39
Intubating LMA 4
Proseal LMA 3
I-gel 3
Bag and mask 2
Smaller ETT 1
Re-intubation attempt 3
2nd dose Suxamethonium 1
Tracheostomy 1
Woken up 4
Sedation and LA 1
Spinal 3
Quinn BJA 2013:110:74-80 (UKOSS 2008-10)
Main findings (case reports and series)
1. Failed intubation rates
2. Wake up or continue - majority continue - from 1990’s
3. Which SAD - majority in literature cLMA
4. 2nd generation LMA - orogastric tubes passed in majority
5. Cricoid pressure - Continued in 50% of cases
? With 2nd generation LMA
6. IPPV vs SV - not clear
7. Maintaining anaesthesia - majority used volatile
Neonatal outcome data
UKOSS Data
Index Cases
(n=57)
Controls
(n=106)
Odds Ratio 95%CI P value
Maternal
morbidity
8 (14.0%) 7 (6.6%) 2.29 0.78 – 6.67 0.13
Maternal ICU 15 (26.3%) 7 (6.6%) 5.05 1.92 – 13.28 0.001
Neonatal
morbidity
2 (3.5%) 8 (7.5%) 0.44 0.04 – 2.33 0.50
Neonatal ICU 20 (35.0%) 23 (21.7%) 1.93 0.94 – 3.94 0.072
Neonatal
mortality
0 (0.0%) 3 (2.8%) 0.00 0.00 – 4.50 0.55
Maternal and neonatal morbidity and mortality
Variable Odds Ratio 95%CI P value
Failed tracheal Intubation 2.72 1.03 – 7.42 0.043
Lowest SpO2 0.964 0.932 – 0.998 0.037
Gestation (weeks) 0.71 0.59 – 0.83 <0.0001
Birth weight (g) 0.9986 0.9979 – 0.993 <0.0001
Apgar score 1 min 0.77 0.62 – 0.94 0.0083
Maternal morbidity 3.39 0.76 – 15.8 0.12
Current pregnancy problems
1.61 0.48 – 5.47 0.44
Variables were entered at P<0.15 after univariate analyses. Multivariate models include failed tracheal intubation or lowest maternal SpO2 and gestation or birth weight to avoid collinearity leaving five variables per model.
Multivariate exact logistic regression results
for factors influencing neonatal ICU admission
Variable Odds Ratio 95%CI P value
Failed tracheal Intubation 2.72 1.03 – 7.42 0.043
Lowest SpO2 0.964 0.932 – 0.998 0.037
Gestation (weeks) 0.71 0.59 – 0.83 <0.0001
Birth weight (g) 0.9986 0.9979 – 0.993 <0.0001
Apgar score 1 min 0.77 0.62 – 0.94 0.0083
Maternal morbidity 3.39 0.76 – 15.8 0.12
Current pregnancy problems
1.61 0.48 – 5.47 0.44
Variables were entered at P<0.15 after univariate analyses. Multivariate models include failed tracheal intubation or lowest maternal SpO2 and gestation or birth weight to avoid collinearity leaving five variables per model.
Multivariate exact logistic regression results for factors influencing neonatal ICU admission
Neonatal outcome data
(Cases reports and series, UKOSS, CESDI)
Message
• Outcome of baby may be related to reason for the CS
• Prevention of hypoxia reduces NICU admission
• Need neonatologists when failed intubation occurs
• Continue in-utero fetal resuscitation
Management of failed intubation and difficult airways in
UK Obstetric Units - an OAA survey
H Swales, M Mushambi, A Winton, K Ramaswamy, A Quinn, M Popat, M Kinsella OAA Dublin 2014
1. Number of failed intubations occurring within the last year with details of how the case(s) was managed.
2. Availability and use of difficult airway equipment
3. Training of anaesthetists in obstetric anaesthesia
Management of failed intubation in
UK Obstetric Units - an OAA survey
No. of FI 55 (41 case details available)
Continued after FI 28/41 (68%)
SAD 30/41 (73%)
2nd generation SAD 18/30 (60%)
IPPV 18/28 (64%)
NDMR 10/18 (56%)
Volatile agent all except one
Videolaryngoscopes – 90% of units and Airtraq most common
Anticipated difficult airway review
80 case reports
0
5
10
15
20
25
30
35
40
Failures
Numbers
Be prepared for failure of plan A – Have a Plan B/C
Anticipated difficult airwayAssessment and planning
1. Assess the nature of airway
difficulties
2. Formulate anaesthetic and
obstetric plan
3. Communicate with teams
and patient
4. Vaginal delivery /operative
delivery (awake or GA)
5. Plan for unplanned
emergency admission
Algorithms/Tables
1. Performing a safe GA
2. Failed intubation drill
3. Decision making table
4. Continue/wake up plan
5. Can’t intubate can’t oxygenate (CICO)
6. Anticipated difficult airway
Safe airway environmentEquipmentTrained primary anaesthetistTrained assistantSenior help identified
Planning, Preparation and Performing
Pre-theatre preparationAirway assessmentExplanation & consentAntacid prophylaxisStarvation
Team Safety CheckWHO checklistPre plan – wake up Vs continuePre plan equipment
Safe Obstetric General Anaesthesia
Rapid sequence inductionPatient positionPre oxygenationInduction agent – adequate dose Cricoid pressure Muscle relaxant – adequate doseGood laryngoscopy technique
Vaginal delivery Caesarean Section
Antenatal anaesthetic assessment
Multidisciplary planning (severe cases)
Primary and back up plans
Documentation of plan (s)Decision: Mode of delivery
MODE OF DELIVERY
Communication(obstetrician, anaesthetist, midwife, patient)
Review management plans
Alert senior personnel
Aspiration prophylaxis
Early working epidural
Airway avoidance
Central neuraxial blockClinical judgement: Spinal, Epidural, CSE, CSA
Fail
Contraindicated
Airway manipulation
Awake (fibreoptic) intubation
Awake tracheostomy
GA
EMERGENCY ELECTIVE
Management of obstetric patient with anticipated difficult airway
Other things to address
List of recommended equipment
Section on training and human factors
Liaise with the DAS unanticipated
guidelines group on RSI and CICO
Level of evidence
No randomised trials to support the majority of our
work.
Most of evidence is by way of case reports/series
and consensus.
Therefore we shall not grade the guidelines
according to level of evidence.
Thanks to
1. Members of the group
2. Steve Robson and
Malachy Columb
3. UKOSS – Neonatal data
4. Sheffield and Manchester
teams for allowing us to use
their data
5. OAA and DAS for paying
our expenses
Anaesthesia 1982
The rapid induction technique for Caesarean section
Why do we still use Suxamethonium?
Young anaesthetists in this country are taught that the use of this drug to facilitate intubation in CS is virtually mandatory….
I have used a technique for 5yrs which avoids both sux and atropine but permits equally rapid intubation ..and there has not been a single case of regurgitation.
Pt is pre-oxygenated with a tilt 10 degrees to the left, cricoid pressure is then applied by a trained assistant and alcuronium 0.25 mg/Kg injected into the iv infusion set port and this is immediately followed by a sleep dose of methohexitone
Letter in Anaesthesia 1982
The rapid induction technique for Caesarean section
Inflation of the lungs is gently begun in time with the
patient’s own inspiration efforts which usually cease
shortly after the injection of methohexitone, so that,
between 10 and 20 seconds after methohexitone has
been given, intubation is easily accomplished and a
conventional maintenance regime instituted.
Letter in Anaesthesia 1982
The rapid induction technique for Caesarean section
Should it prove impossible to intubate the patient, atropine is given, oropharyngeal toilet carried out and ventilation is maintained by mask with an airway inserted if necessary. Cricoid pressure is maintained throughout the procedure using a mechanical device which I have developed partly for this eventuality, which will be described in a paper which is in preparation.
Letter in Anaesthesia 1982
The rapid induction technique for Caesarean section
Should it prove impossible to intubate the patient, atropine is given, oropharyngeal toilet carried out and ventilation is maintained by mask with an airway inserted if necessary. Cricoid pressure is maintained throughout the procedure using a mechanical device which I have developed partly for this eventuality, which will be described in a paper which is in preparation.
A I Brain, Anaesthesia:1982
Any comments and questions
Variable Odds Ratio 95%CI P value
Failed Tracheal Intubation 1.93 0.94 – 3.94 0.072
Maternal Age (years) 1.49 0.29 – 7.52 0.63
Apgar Score 1 minute 0.50 0.38 – 0.66 <0.0001
Urgency Grade 0.81 0.56 – 1.17 0.27
Birth Weight (g) 0.9989 0.9984 – 0.9995 0.0005
Lowest SpO2 (%) 0.972 0.946 – 0.998 0.036
Gestation (weeks) 0.65 0.55 – 0.77 <0.0001
BMI (kg m-2) 1.01 0.96 – 1.07 0 .60
Ethnicity (white) 1.83 0.80 – 4.21 0.30
Maternal Morbidity 3.76 1.27 – 11.14 0.017
Current Pregnancy Problems 4.37 2.06 – 9.27 0.00012
Smoking history 1.20 0.55 – 2.60 0.65
Univariate logistic regression for factors influencing neonatal ICU admission
Anticipated difficult airwayfailures and solutions
Epidurals (64%)
Dural tap (3) - CSA (High BMI 62 and 83)
Failed to top up - Failed AFI – ILMA and intub through ILMA
- GA with glidescope
- Spinal – failed – AFI
CSE (33%)
Dural tap - CSA
Intra-op pain - Remifentanil
Spinal(29%)
Failed spinal - GA - FI – Glidescope
GA (MOH) - Inhalational and size 5 ETT
OAA/DAS obstetric guidelines
planConsultation period in 2014
Publish end 2014 (?2015)
Where- submit to:
Background papers – IJOA
Guideline paper – Anaesthesia
Algorithms – (? copyrights to DAS and OAA)
IJOA & OAA/DAS website
Links to DAS/OAA website for extra papers or information
Why do we need national obstetric
difficult airway guidelines?
1. Reduced GA rates &
reduced number of
GAs per trainee
2. Morbidity/mortality
related to GA
3. DAS guidelines
4. National survey of
obstetric guidelines in 2009
5. Coroners Rules and
preventable deaths
6. Request from DAS
and OAA members
7. Pregnant woman
- Physiological
- Anatomical
- Foetus
8. Labour ward
environment
Why do we need national obstetric guidelines? –
Training issues
Number of C/S under GAs ↓
1982 - 425
1998 - 68
2006 - 41
Number of GAs per trainee ↓
1982 - 18
1998 - 4
2006 - 1
Johnson Anaesthesia 2000Searle IJOA 2008
Total LSCS
GA LSCS
GAs per trainee
Why do we need national
obstetric guidelines
1. Reduced GA rates &
reduced number of
GAs per trainee
2. Morbidity/mortality
related to GA
3. DAS guidelines
4. Survey 2009
• CEMACE – 3 airway deaths
- Aspiration on emergence ?use of orogastric tube
- Unrecognised oesophageal intubation
• NAP4 - 4 cases - all alive
- Failed AFI- Failed needle FON (obese)- Failed proseal/Bonfils
success with McCoy
Preventable deaths (CMACE) and advanced airway skills (NAP4)
Why do we need national
obstetric guidelines
1. Reduced GA rates &
reduced number of
GAs per trainee
2. Morbidity/mortality
related to GA
3. DAS guidelines
4. Survey 2009
National survey of obstetric difficult airway guidelines and equipment
A Joseph, J Dedhia, M. Mushambi
Anaesthetics, University Hospitals of Leicester Leicester, UK
IJOA 2009;18:S40
Guidelines used in 131 hospitals
Guidelines
DAS guidelines 21 (16%)None 3 (0.2%)
Methods to improve laryngoscopy
33% did not advice change in head/neck position.
38% did not advice change of blade
32% did not advice use of bougie
Methods for oxygenation
Nasopharyngeal airway 21 (16%)
Proceed or wake up
Most units did not mention indications for continuing
Joseph IJOA 2009;18:S40
Survey findings
16% using unmodified DAS guidelines
Maximum attempts of laryngoscopy
Methods to improve laryngoscopy
Methods of oxygenation following failed laryngoscopy
Most units did not mention indications for continuing
Exclusion of Obstetrics in the RSI algorithm