The Neuroscience of the Gut -...

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98 The Neuroscience of the Gut http://www.scientificamerican.com/article.cfm?id=the-neuroscience-of-gut Princeton University scientist Bonnie Bassler compared the approximately 30,000 human genes found in the average human to the more than 3 million bacterial genes inhabiting us, concluding that we are at most one percent human . We are only beginning to understand the sort of impact our bacterial passengers have on our daily lives. Autism and microbiome – is there a connection? 20.000 human genes, but about 3.000.000 microbial genes! (1%!) Christl Meyer, AIDS Research, Vienna/ Austria, 2018 https://www.youtube.com/watch?v=qdRu-S6S6qM Microbiome: When Good Bugs Go Bad Yasmine Belkaid, NIH 21.5.2014

Transcript of The Neuroscience of the Gut -...

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TheNeuroscienceoftheGut

http://www.scientificamerican.com/article.cfm?id=the-neuroscience-of-gut

PrincetonUniversityscientistBonnieBasslercomparedtheapproximately30,000humangenesfoundintheaveragehumantothemorethan3millionbacterialgenesinhabitingus,concludingthatweareatmostonepercenthuman.Weareonlybeginningtounderstandthesortofimpactourbacterialpassengershaveonourdailylives.

Autismandmicrobiome–isthereaconnection?

20.000humangenes,butabout3.000.000microbialgenes!

(1%!)

ChristlMeyer,AIDSResearch,Vienna/Austria,2018

https://www.youtube.com/watch?v=qdRu-S6S6qM Microbiome: When Good Bugs Go Bad — Yasmine Belkaid, NIH 21.5.2014

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Doi.10.1038/Nature12199NIHScientistsfindlinkbetweenallergicandautoimmunediseasesinmousestudy

Nature.2013June27;498(7455):506–510.doi:10.1038/nature12199.Bach2represseseffectorprogrammestostabilizeTreg-mediatedimmunehomeostasis

RegulatoryT-cells(Tregs)andhealth

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MichaelSkinnerandcolleaguesfoundthatifpregnantrats,thatgotasubstanceinjectedthatdepressedandrogens,theoffspringbecameillandthiswasinheritedoverseveralgenerations.„...101casesofepigeneticinheritance...“

EvaJablonkaisProfessorattheCohnInstitutefortheHistoryandPhilosophyofScienceandIdeas,Tel-AvivUniversity.

MarionLambwasSeniorLectureratBirkbeckCollege,UniversityofLondon.

EvaJablonkaandMarionLamb2009-02-05

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Methyl-andAcetylgroups

regulategene-expression

ChristlMeyer,AIDSResearch,Vienna/Austria,2018

https://www.nature.com/articles/s41598-018-23841-1EpigeneticalterationsareassociatedwithmonocyteimmunedysfunctionsinHIV-1infection3.4.2018InthecaseofHIV,epigeneticsisinvolvedinregulationofvirallatencyandviralreplication.

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Nutritionandlife-styleinfluencegeneexpressionandmightchangehereditybyepigenetics!

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Monogeneticdiseasemultifactorialdisease

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Food-derivedopioidpeptidesinhibitcysteineuptakewithredoxandepigeneticconsequences

MalavS.Trivedia,JayniS.Shaha,SaraAl-Mughairya,NathanielW.Hodgsona,BenjaminSimmsa,GeertA.Trooskensb,WimVanCriekingeb,RichardC.Detha,⁎aDepartmentofPharmaceuticalSciences,NortheasternUniversity,Boston,MA02115,USAbDepartmentofMathematicalModelling,StatisticsandBioinformatics,FacultyofBioscienceEngineering,GhentUniversity,Ghent9000,BelgiumReceived21January2014;receivedinrevisedform7April2014;accepted5May2014Abstract

JournalofNutritionalBiochemistryxx(2014)xxx–xxx

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Literature: Jörg Blech: Gene sind kein Schicksal S. Fischer-Verlag

Affection triggers genes (stress hormon receptor- better stress resistance!)

RESILIENCE

Loveandcaretriggergene-expression

ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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Epigeneticchangesduringlifeinidenticaltwins.

SPEKTRUMDerWissenschaftSpezial2/13GeneundUmwelt

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TheDutchFamine Sincesmallbirthweightisassociatedwithanincreasedriskofchronicdiseasesinlaterlife,andpoormaternalnutritionduringgestationcontributestorestrictedfetaldevelopment,maternalmalnutritionmaybeacauseofincreaseddiseasesusceptibilityinadulthood. TheDutchfamineof1944orthe"HungerWinter"duringWorldWarIIservesasanepidemiologicalstudythatisusedtoexaminetheeffectsofmaternalunder-nutritionduringdifferentgestationalstages.Theperiodofmaternalstarvationisshowntohavelimitedintrauterinegrowthandhasbeenidentifiedasoneofthemostimportantcontributorstocoronaryheartdiseaseaswellasotherchronicdiseaseslaterinlife.ThesefindingsagreewellwithBarker'shypothesis;itsupportsthetheorythatmaternalunder-nutritionleadstoalowerbirthweightduetorestrictedintrauterinedevelopmentandultimatelyleadstohigherrisksofchronicconditionsinadultlife,overmorethanthenextgeneration. ChristlMeyer,AIDSResearch,Vienna/

Austria,2018

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Biologicalmemoriesofpastenvironments-EpigeneticpathwaystohealthdisparitiesZanetaM.ThayerandChristopherW.KuzawaDepartmentofAnthropology;theCenteronSocialDisparitiesandHealthattheInstituteforPolicyResearch;NorthwesternUniversity;Chicago,ILUSAEpigenetics6:7,1-6;July2011;LandesBioscienceHumanhealthtendstomirrorgradientsinsocialstandingrelatedtoclass,ethnicityandrace..Here,wereviewresearchrelatedtothreedomainsofenvironmentalexposurethatpointtoepigeneticcontributionstohealthdisparities:nutrition,psychosocialstressandenvironmentaltoxicantexposure.Wesuggestthatfutureresearchinenvironmentalepigeneticsfocuson

establishingthereversibilityofstress-inducedepigeneticmodifications,andalsoonidentifyingpositiveepigeneticeffectsofenvironmentalenrichment.

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ON OFF

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Cell Research advance online publication 20 September 2011; doi: 10.1038/cr.2011.158

Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA

Lin et al. Published online 20 September 2011.

Micro-RNA of another species (nutrition from rice) can trigger gene regulation in humans.

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1. Genetics,HIVandtheImmuneSystem2. Epigenetics3. MicrobesinEvolution4. Immunization5. WhatdoesitmeantobeHuman?

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Bacterium

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BacteriophageinfectingBacterium

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(DLO,idw - Max-Planck-Institut für chemische Ökologie,30.04.2008)

Viruses „fertilized“ ancient cells . Researchers from Jena (Germany) found complete viral genetic material in the brown alga Ectocarpus siliculosus.

Horizontal Gentransfer The driving force behind evolution! Journal BMC Evolutionary Biology.

Elektronenmikroskopische Aufnahme von reifen EsV-1 Viruspartikeln © MPI für chemische Ökologie/Delaroque

ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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This is an image of Proteus mirabilis colonies from James Shapiro's research. Shapiro is a bacterial geneticist at the University of Chicago, interested in pattern formation during colony growth and "natural genetic engineering".

This is thought to occur when some organisms actively restructure their genomes in response to harsh environmental conditions.

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Thisflower-likeimageistheworkofEshelBen-Jacob,a

professorofphysicsatTelAvivUniversityinIsrael.•  Working with colleagues at the

Center for Theoretical Biological Physics at the University of California, San Diego, he wants to unravel what it is that makes bacteria so adept at survival by looking at pattern formation in complex dynamic systems alongside the molecular biology and biophysics of bacteria.Ben-Jacob's work is artificially coloured, but the pattern is produced by the bacteria responding to stresses put upon them. For example, by limiting the food source, the colony can be made to reorganise itself into long tendrils, increasing its surface area to find more nutrients.

Surfaceexpansionasresponsetoalackofnutrition!

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In this image, also by Ben-Jacob, you can see the narrow tentacles reaching out as the bacteria struggle to find nutrients. In order to flourish in difficult living conditions the colony must adapt. This requires communication and cooperation from the individual microbes to organise the entire colony.

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Cooperation and Symbiosis

Lynn Margulis

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Evolution and Symbiosis

Nucleus

Chloroplast

Mitochondrion

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ChristlMeyer,AIDSResearch,Vienna/Austria,2018

Cell,15May2013Copyright©2013ElsevierInc.Allrights

reserved.10.1016/j.cell.2013.04.029

Refersto:

Malaria-InfectedErythrocyte-DerivedMic...Authors

NetaRegev-Rudzki,DannyW.Wilson,TeresaG.Carvalho,XavierSisquella,

BradleyM.Coleman,MelanieRug,DejanBursac,FionaAngrisano,MichelleGee,

AndrewF.Hill,JakeBaum,AlanF.Cowman

123

Malaria

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•  Hundredsofhumangeneswerefoundtobemoreconservedwithnon-mammalsthanwithmostmammals.Fewofthesegenesoverlappedwithknownhorizontaltransferredgenes.Thisindicatedthathorizontalgenetransferismorecommonthanweexpectedinthehumangenome.ThisstudyprovidedinsightintopotentialmechanismsofHGTinthehumangenome.

Widespreadofhorizontalgenetransferinthehumangenome:WenzeHuangetal.BMCGenomics201718:274https://doi.org/10.1186/s12864-017-3649-y

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Reyes,A.etal.Nature466,334-340(2010)

Morethan80%oftheviralgeneticsequencesfound,whichincludedsequencescharacteristicofbothanimalandbacterialviruses,haveneverbeenreportedpreviously."Thisisalargelyunexploredworld,"saysJeffreyGordonatWashingtonUniversityinStLouis,Missouri,andanauthoronthepaper,whichispublishedinNaturetoday1."Wearetrulydistinctlifeforms—sumsofmicrobialandhumanparts."

We may need to re-evaluate how we think about evolution Alastair Crisp Inhumans,theyconfirmed17previously-reportedgenesacquiredfromhorizontalgenetransfer,andidentified128additionalforeigngenesinthehumangenomethathavenotpreviouslybeenreported.Inhumans,someofthegeneswereinvolvedinlipidmetabolism,includingthebreakdownoffattyacidsandtheformationofglycolipids.Thesemoleculesareamainpartofthecellmembraneandexo-andendosomes.

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“We need to enhance some of the organisms that are present, but depleted ... Maybe we have to replace some of those vanished organisms, perhaps with

isolates from the Amazon or from Africa. And ultimately, we have to monitor.”

DR. MARTIN BLASER Authorof"MissingMicrobes"

Viewlarger An estimated 30 trillion cells in your body—less than a third—are human. The other 70-90% are bacterial and fungal. by Gaby D'Allesandro /© AMNH

by Gaby D'Allesandro /© AMNH

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HumanMicrobiome

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https://www.youtube.com/watch?v=qdRu-S6S6qM Microbiome: When Good Bugs Go Bad — Yasmine Belkaid, NIH 21.5.2014

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AntibioticsUseinHumansandAnimals

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Hospitals

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“We need to enhance some of the organisms that are present, but depleted ... Maybe we have to replace some of those vanished organisms, perhaps with

isolates from the Amazon or from Africa. And ultimately, we have to monitor.”

DR. MARTIN BLASER Authorof"MissingMicrobes"

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Adiseasethathasbeengonethroughsuccessfullycanbecomparedtoaprocessoflearning!Itcouldhavebeenaninfectionfromoutsideoranimbalancefrominside.Manychildrenbecomemoremature,notonlyintheirbodybutevenintheirmindandspirit.

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http://www.cell.com/cell/fulltext/S0092-8674(17)31509-X A Viral (Arc)hive for Metazoan Memory Nicholas F. Parrish

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Retrovirus-likeGagProteinArc1BindsRNAandTrafficsacrossSynapticBoutons Published:January11,2018

DOI:http://dx.doi.org/10.1016/j.cell.2017.12.022

Takentogether,ourresultspointtoatrans-synapticmRNAtransportmechanisminvolvingretrovirus-likecapsidsandextracellularvesicles.

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Self/Nonself1:4,328-334;October/November/December2010©2010LandesBiosciencewww.landesbioscience.com/journals/selfnonself/article/13315DOI:10.4161/self.1.4.13315Nohumanproteinisexemptfrombacterialmotifs,notevenoneBrettTrost,1GuglielmoLucchese,2AngelaStufano,2MikBickis,3AnthonyKusalik1andDarjaKanduc2,*1DepartmentofComputerScience;and3DepartmentofMathematicsandStatistics;UniversityofSaskatchewan;Saskatoon,Canada;2DepartmentofBiochemistryandMolecularBiology;UniversityofBari;Bari,Italy

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• ChristlMeyer,Vienna,Austria,January24,2015/[email protected]

• GENEORVIRUSINHEALTHANDDISEASE:IT`SALLABOUTSELFANDNON-SELF

• Conclusion:• “HIV“isnotarealexistingvirusbutastatisticalconstruct!• “HIV”sequencesareeverywhere(atleastendogenousin“homosapiensneanderthalensis”,inhumanchromosome8andtumortissue),consequentlytheexistenceof“HIV”beinganinfectiousexogenousvirushasnotbeenproven!• Stressdrivesdiseaseandfastevolutionbyinflammationandchangeofgeneticandgenomicdiversity.• Thereisastrongimpactonthegeneticcomponentsknownas“HIV”whichareinfluencedbythediversityfromthegenesoftheHLAsystem.“HIV”transmissionfrommothertochildmightbecomelifepromotingfortheoffspring,leadingtonewgenesfortheHLAsystem.Insomeconstellationsallergiesmightresult.• Horizontalgenetransferandendogenizationofmicrobialgenes,aswellastransportofmicroRNAsandproteinsfordifferentprocessesbetweencellsandincellularfunctionsprovideamorecomplexviewofgeneexpressionintheevolutionarycontext.• Activationofgeneexpression,(food,sperm)allergy,selfandnon-selfdifferentiation(autoimmunity)provideanewperspectiveonhealthanddisease.• Theterm“virus”isnotaclearlydefinedentity;itisdefinedbytheinteractionofabody´sreactiontoanon-selfparticle. 135ChristlMeyer,AIDSResearch,Vienna/

Austria,2018

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1. Genetics,HIVandtheImmuneSystem2. Epigenetics3. MicrobesinEvolution4. Immunization5. WhatdoesitmeantobeHuman?

136ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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Outdoorpigshadmore‘friendly’gutbacteriathanindoorpigs.D.BURTON/NATUREPL.COM

Immunesystemgetsaboostfromearlyexposuretobacteria.NatashaGilbert

DeniseKelly,agutimmunologistattheUniversityofAberdeen,UK,whoworkedonthestudy,saysthattheresultsprovidethefirstdirectlinkbetweenearlyexposuretomicrobes,immunehealthandgeneexpression(I.E.Mulderetal.BMCBiol.7,79;2009).Untilnow,shesays,thatlinkhadbeencircumstantial."Therehasbeenalotofhearsayaroundgutmicrobiotaandhowitinfluencesimmunefunctionandsusceptibilitytodiseasesandallergies."

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• Wen, L. et al. Nature doi:10.1038/nature07336 (2008). • Turnbaugh, P.J., et al. Nature 444, 1027–1031 (2006). • Mazmanian, S.K., Round, J.L. & Kasper, D.L. Nature 453, 620-625 (2008).

Published online 19 September 2008 | Nature | doi:10.1038/news.2008.1121

Gut microbes fend off diabetes in mice Microbes that call the intestines home help ward off type 1 diabetes in mice, researchers have found.

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Published online 14 July 2010 | Nature | doi:10.1038/news.2010.353

The gut's 'friendly' viruses revealed DNA sequencing reveals a new world of bacterial viruses in our intestines.

"Thiskindofstabilityimpliesthatthereisasymbiosisbetweenbacteriaandviruses,"commentsMartinBlaseratNewYorkUniversityMedicalCenter."Thisisdifferentfromapredator-prey,oranarmsrace,situation.Thisisapictureofamoresettledexistence,inwhichthedifferentpopulationsareworkingtogether.“Reyes,A.etal.Nature466,334-340(2010).

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RESOURCESVaccineSchedulesAccordingtotheCDC,duringthe2015–16schoolyear,mediankindergartenvaccinationcoveragewasnearly95%forMMR(94.6%),DTaP(94.2%),andvaricellavaccine(94.3%),whichwassimilartothepreviousschoolyear.Source:CDC�Instarkcontrast,theCDCclaimsthevastmajorityofadultsarenotvaccinated,under-vaccinated,orout-of-date

From5toabout70doses! 142

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Dr.StefanLanka(Biologist/Germany)wontheprocessatcourtconcerningthetopicthattheredoesnotexistascientificpaperthatcanprovetheexistenceofthe„measlesvirus“.Thisinformationhastospreadtothesociety!

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What should be considered further concerning vaccinations: The entry portal (muscle, blood) does not correspond with the natural infection site of the germ (mouth, nose, skin).

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Growthmaterial:• Verocells(continuouscelllineofgreenmonkeykidneycells)• HELAcells(Humancancercellline)• ChickeneggsIngredients:• GeneticallyengeneeredAntigens• Antibiotics,Formaldehyd,Thiomersal(Quicksilvercontaining)• Aluminum-hydroxid• Nanotechnology(Nanoparticle),i.e.:• Oilinwatersuspension• Squalen• MF59• ASO3,AFO3• DLalpha-Tocopherol(VitaminE-derivate)• Virosomes

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Figure1.Thesexdistributionofthemajorautoimmunediseases.Thenumbersabovethebarsrefertothetotalnumberofdiseasecases(×1,000,000)intheUSA1,7.

CarolineC.WhitacreDepartmentofMolecularVirology,ImmunologyandMedicalGenetics,TheOhioStateUniversityCollegeofMedicineandPublicHealth,Columbus,OH43210-1239,USA.

146ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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147ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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Correlationorcausation?

148ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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JournalofInorganicBiochemistry Volume 105, Issue 11, November 2011, Pages 1489-1499

Do aluminum vaccine adjuvants contribute to the rising prevalence of autism? lLucijaTomljenovicaChristopher A.Shawab

Autismspectrumdisorders(ASD)areseriousmultisystemdevelopmentaldisordersandanurgentglobalpublichealthconcern.DysfunctionalimmunityandimpairedbrainfunctionarecoredeficitsinASD.Aluminum(Al),themostcommonlyusedvaccineadjuvant,isademonstratedneurotoxinandastrongimmunestimulator.Hence,adjuvantAlhasthepotentialtoinduceneuroimmunedisorders.Ourresults,supportedbytheHill'scriteriaforestablishingcausalitybetweenexposure

andoutcomeindicatethatacausalrelationshipmayexistbetweentheexposuretoAlfromvaccinesandtherisingprevalenceofautismintheWesternworld.

149ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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published:12February2018doi:10.3389/fimmu.2018.00073

•  ProlactinandAutoimmunityVâniaVieiraBorba,GiseleZandman-GoddardandYehudaShoenfeld

Tissue Antigens. 2007 Jul;70(1):42-52. Extraordinary cross-reactivity of an autoimmune T-cell receptor recognizing specific peptides both on autologous and on allogeneic HLA class II molecules.

Hansen BE, Rasmussen AH, Jakobsen BK, Ryder LP, Svejgaard A. 1

Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. [email protected]

Prolactin(PRL)hasabioactivefunctionactingasahormoneandacytokine.Itinterfereswithimmunesystemmodulation,mainlyinhibitingthenegativeselectionofautoreactiveBlymphocytes.DopamineisaneffectiveinhibitorofPRL.Certainly,motherhoodrepresentsoneofthemostremarkablechallengesfortheimmunesystem.

150ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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Vaccine-inducedautoimmunity:theroleofmolecularmimicryandimmunecrossreactionYahelSegalandYehudaShoenfeld,Cellular&MolecularImmunologyadvanceonlinepublication,5Mach2018;doi:10.1038/cmi.2017.151www.nature.com/cmiShebaMedicalCenter,Tel-Hashomer,affiliatedwiththeSacklerFacultyofMedicine,TelAvivUniversity,Molecularmimicryisaprototypeofsuchprocesses,whereinanimmunereactiondirectedagainstforeignpathogenicelements,bearingsimilaritytohumanproteins,mayevolveintoanautoimmuneprocesstargetingthehomologousself-proteins.crossreactivity.Itseemssomewhatironicthenthatvaccinesmayinducetheverysameimmunecrossreactivitytheyservetoprevent.

151ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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Narcolepsy,2009A(H1N1)pandemicinfluenza,andpandemicinfluenzavaccinations:Whatisknownandunknownabouttheneurologicaldisorder,theroleforautoimmunity,andvaccineadjuvantsS.SohailAhmeda,*,PeterH.Schurb,NoniE.MacDonaldc,LawrenceSteinmanhttp://dx.doi.org/10.1016/j.jaut.2014.01.033Researchareneededtoexplaintheobservedincreaseinnarcolepsywith2009A(H1N1)pandemicinfluenzainfectionandwithEuropeanAS03-adjuvantedA(H1N1)pandemicvaccinebutnotwiththeMF59-adjuvantedA(H1N1)pandemicvaccinenorwiththeCanadianAS03-adjuvantedA(H1N1)pandemicvaccine

152ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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ENVIRONMENTANDAUTOIMMUNITY

Electrosmogandautoimmunedisease

TrevorG.Marshall1•TrudyJ.RumannHeil2 Publishedonline:13July2016 _TheAuthor(s)2016.ThisarticleispublishedwithopenaccessatSpringerlink.com

AbstractStudiesinmicehaveshownthatenvironmentalelectromagneticwavestendtosuppressthemurineimmunesystemwithapotencysimilartoNSAIDs,yetthenatureofanyElectrosmogeffectsuponhumansremainscontroversial. Previously,wereportedhowthehumanVitamin-Dreceptor(VDR)anditsligand,1,25-dihydroxyvitamin-D(1,25-D),areassociatedwithmanychronicinflammatoryandautoimmunediseases.Wehaveshownhowolmesartan,adrugmarketedformildhypertension,actsasahigh-affinitypartialagonistfortheVDR,andthatitseemstoreversediseaseactivityresultingfromVDRdysfunction.WeherereportthatstructuralinstabilityoftheactivatedVDRbecomesapparentwhenobservinghydrogenbondbehaviorwithmoleculardynamics,revealingthattheVDRpathwayexhibitsasusceptibilitytoElectrosmog.Further,wenotethatcharacteristicmodesofinstabilitylieinthemicrowavefrequencyrange,whichiscurrentlypopulatedbycellphoneandWiFicommunicationsignals,andthatthesusceptibilityisliganddependent.Acase seriesof64patient-reportedoutcomessubsequenttouseofasilver-threadedcapdesignedtoprotectthebrainandbrainstemfrommicrowaveElectrosmogresultedin90%reporting‘‘definite’’or‘‘strong’’changesintheirdiseasesymptoms. Thisismuchhigherthanthe3–5%ratereportedforelectromagnetichypersensitivityinahealthypopulationandsuggeststhateffectivecontrolofenvironmentalElectrosmogimmunomodulationmaysoonbecomenecessaryforsuccessfultherapyofautoimmunedisease.

153ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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1. Genetics,HIVandtheImmuneSystem2. Epigenetics3. MicrobesinEvolution4. Immunization5. WhatdoesitmeantobeHuman?

154ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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When is stress good for me?

155ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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156

Stress can produce free radicals and thus change the oxidative potential of the cell.

Aloweringcanalsobetriggeredbynutrition:Emptycaloriesinsteadofenergeticelectrons–information.

ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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PhotonstriggerenergeticelectronsPhotosynthesis–

Mitochondriagainenergy-ATPvegetables,fruits

157

WOW!

VitaminD

ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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158ChristlMeyer,AIDSResearch,Vienna/Austria,2018

https://www.heartmath.org/gci-commentaries/properties-of-water-does-water-have-memory-or-consciousness/

https://www.youtube.com/watch?v=DTI0OePtg4o WirkungelektromagnetischerFelderundSchwingungenaufLebendiges-Dr.U.Warnke–201416.6.2015

https://www.youtube.com/watch?v=R8VyUsVOic0 WaterMemory(Documentaryof2014aboutNobelPrizelaureateLucMontagnier)28.1.2016

Proteinschangeconformationbyelectromagneticinfluence

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159

Electromagnetismisauniveralstate

ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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Paracelsus:Everythingisdependentontheconcentration

160ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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K.Zänker:DasImmunsystemdesMenschen(Beck´scheReiheS114/115)Testswithrabbitsandtumorcells

tumors

Notumors,morekillercells!

Strokesandtalking

Nutritionanddrinkingwater

161ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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Gutgut.bmj.comGut1998;42:414-420doi:10.1136/gut.42.3.414

MotilityandfunctionaldisordersFunctionalgastrointestinaldisorders:

psychological,social,andsomaticfeatures

-AuthorAffiliationsaDepartmentofGastroenterology,RoyalNorthShoreHospital,Sydney,Australia,bDepartmentofMedicine,RoyalNorthShoreHospital,cDepartmentAcademic

Psychiatry,RoyalNorthShoreHospitalAssociateProfessorJEKellow,DepartmentofMedicine,RoyalNorthShoreHospital,St

Leonards,NSW2065,Australia.

162ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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Itistrue:Thediagnosis(prognosis)ofadiseasecouldmanifestit–eveninatotalhealthyperson.ThisiswhatwecalltheNocebo-effect!ThecontraryisthewellestablishedPlacebo-effect.

163ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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AutopoiesisThetermreferstoasystemcapableofreproducingandmaintainingitself.Thetermwasintroducedin1972byChileanbiologistsHumbertoMaturanaandFranciscoVarelatodefinetheself-maintainingchemistryoflivingcells.Sincethentheconcepthasbeenalsoappliedtothefieldsofcognition,systemstheoryandsociology.

164ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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165ChristlMeyer,AIDSResearch,Vienna/Austria,2018www.heartmath.org

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Communication between living creatures influences cell-communication and thus health and disease!

You are your thoughts and your feelings!

166ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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167ChristlMeyer,AIDSResearch,Vienna/Austria,2018

Self-Regulation:Solveyourproblems!

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Meditation

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169ChristlMeyer,AIDSResearch,Vienna/Austria,2018

Wearecomingtounderstandhealthnotastheabsenceofdisease,butratherastheprocessbywhichindividualsmaintaintheirsenseofcoherence.(A.Antonovsky)Scienceofthehearthttps://www.heartmath.org

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ChristlMeyer,AIDSResearch,Vienna/Austria,2018 170

GERMANISCHEHEILKUNDE_Mag.Theol.Dr.GeerdRykeHamerAshockcanleadtoadisease.Thetraumasetsavisiblemarkinthebrain(HamerscherHerd)..Findingthecause,willleadtotherighttreatment.Duringthehealingphasemicroorganismsareworkingforregainingthebalance.

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171

VIRUS=POISONInfectus=infectuousInfection=comingfromoutsideandcausingdisease

INCONTRAST–FACT:Actingfrominsideinresponsetostimulation!

ChristlMeyer,AIDSResearch,Vienna/Austria,2018

Theoldterms(gene,virus)donotcorrespondwiththelatestscientificfindings!

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"All Truth Goes Through Three Stages:

• First it is ridiculed.

•Then it is violently opposed.

• Finally, it is accepted as self-evident." –

- Arthur Schopenhauer-

172ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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Hippocraticoath:„Astodiseases,makeahabitoftwothings–tohelp,oratleasttodonoharm.“(Hippocrates,5thCenturyB.C.E.GreekPhysician,regardedasthefatherofmedicine)

„Lettheoriesdieinsteadofhumans!“KarlPopper:Austrian/BritishPhilosopher

173ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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evolution/improve-ment

time

TechnicalImprovementversusAwareness/Ethics

174ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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Humans(andotherlivingcreatures)aretheoutcomeofmicrobialcompetitionandsymbiosis.Bacteriophages,bacteria,protists,archaeaandfungicreatedourancestorsandourowngenesandcontributedtotheirspecificity.Weinheritedourancestors´lifestyle(history)andcombineitwithourownepigenetics.Theprincipleoflife(anduniverse)isstillnotrevealed:God,spirit,self(autopoiesis),bychance,ahigherprinciple,eternallaw,scientificlaws;….???Evolutionisstillgoingonandformostofhumanitythepaceistoofast!Weneedtimeforadaptation!Remember:Itisyouyourselfwhohasthepowerofhealingyourself.Societyisresponsiblefortheconditionsthatdopromotelifeandhealth,likeworkingconditions,income,housing,educationsystems,justice,freedomanddemocracy,….Wehavetofocusmoreon„non-materialprinciples“,whichwehaveneglecteduntilnow.

175ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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176ChristlMeyer,AIDSResearch,Vienna/Austria,2018

Lifeiscomprisedbyahomeostaticbalance.Genesandtheenvironnementinteracttogether.Thematerialneededcomesfromhealthynutrition.Youneedenergeticelectronsandphotonstobuildandsustaintheelectromagneticfieldyouare.Humans(cells)areresonators.Theprogramisbasedonyourspirit,moodandmind.

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Theidealswhichhavealwaysshonebeforemeandfilledmewiththejoyoflivingaregoodness,beauty,andtruth.Tomakeagoalofcomfortorhappinesshasneverappealedtome;asystemofethicsbuiltonthisbasiswouldbesufficientonlyforaherdofcattle.--AlbertEinstein

177ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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ChristlMeyer,AIDSResearch,Vienna/Austria,2018 178

Thereareonly2races:Thedecentandtheundecent..Wehavetopromotethedecent.WhatahumanbeingneedsisaMEANINGFORLIFE!(VictorFrankl/Austrianprychiatrist)

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179ChristlMeyer,AIDSResearch,Vienna/Austria,2018

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Thank you for your attention!

Contact: [email protected] http://www.christl-meyer-science.nethttps://independent.academia.edu/ChristlMeyer

ChristlMeyer,AIDSResearch,Vienna/Austria,2018