The neuropsychiatry of stroke John O’Donovan. Stroke Third most common cause of death post MI and...
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The neuropsychiatry of stroke
John O’Donovan
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Stroke
• Third most common cause of death post MI and cancer• 11% of deaths in UK and Wales• 20% of acute beds and 25% of long term beds occupied
by stroke patients• Acute focal neurological deficit resulting from vascular
disease. • TIA not very accurate really, concept of less then 24
hours, note TIA with risks can suggest a 30% chance of a full stroke happening. Be cautious with these patients!
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Types of stroke
• Nearly all arterial, less then 1% is venous. • 85% are infarctions• 15% are haemorrhagic, which can be
intercranial or subarachnoid• 3 mechanisms of ischemic stroke, thrombosis,
embolism or hypoperfusion.
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Risk factors
• Age: incidence doubles each decade post 55• Hypertension: 25% of adult population 140/90• Smoking• Diabetes: 2 fold increase• A fib: 5% of over 60s, 4% per year risk of stroke • Dyslipidemia • Alcohol • Obesity • Carotid stenosis • Drug misuse
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Lacunar Stroke
Small discrete lesion, generally deep tissue and associated with hypertension/ischemia. 5 classical types 1: pure motor hemiparesis 2: sensorimotor 3: pure sensory 4: ataxic hemiparesis 5: dysarthria/clumsy Hand
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Lacunar Stroke 2
Can be associated with cognitive impairment Can be associated with depression Can be silent Can be associated with unusual sub types such as antiphospholipid AB syndrome and CADASILNo cortical signs No neglectDWI test of choice. If pronnounced may cause leucoaraiosis
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Large Vessel Disease
Cortical signs Note: amarosis fugax Generally large vessel occlusion, embolicTends to be MCA territoryACA is less common Lesion site is obviously important for presentation
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Haemorrhage
Much less common, 10-15%Much worse outcomeBig risk is hypertension
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SAH
Nearly always rupture of an aneurysm Mortality of 50% 10/100,000 incidence
Risks: genetics, connective tissue problems, smoking, hypertension, female sex
Also AVMCavernous angiomas
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Rare causes of stroke
• CADASIL • Venous • Shunting, PFO• Moya moya disease• Carotid dissection• Vasculitis • Thrombophilias • Mitochondrial • Farby’s disease
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Psychiatry and stroke
Psychiatric patients• Risk factors • Smoking • Increased mortality • Insulin resistance • Poor compliance with
medical therapy • Common problem
Medical patients• Post stroke depression or
mood changes • Post stroke emotionalism • Post stroke cognitive
impairment• Stroke risk and
development of dementia
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Stroke and psychiatric effects
• Basic ideas • Certain stroke syndromes are likely to cause
specific presentations. • Stroke may not always be apparent. • As patients get older the odds of having
cerebrovascular disease increases. • Stroke is very common and should be considered
in atypical depression, cognitive impairment or any unusual psychiatric presentation.
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Prevalence of psychiatric disorders post stroke
• Depression: 35%• Mania: rare• Bipolar disorder: rare• Anxiety disorder: 25%• Apathy : 20%• Psychosis: rare• Pathologic affect 20%• Catastrophic reaction: 20%
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Depression post stroke
• Prevalence studies vary from 10-79% depending on location of study, time of study and case ascertainment.
• In general hospital studies report higher rates.• Interesting clinical point is that depression
more or less immediately post stroke does not predict further problem
• Depression at six months, suggests ongoing problems for another year.
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Risk factors for depression post stroke
Definite• Prior psychiatric illness • Dysphasia • Poor social support
Argued• Age • Gender • Lesion location • Lesion volume • Impaired ADLs
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Clinical features
Core psychopathology• Core features of sustained
low mood and anhedonia need to be distinguished from common medical problems such as fatigue and sleep disturbance.
• Concentrate on cognitive features.
• Some authors argue in favor of a more somatic approach
Stroke related depression• Peak at 3-6 months post
event. • Generally prevalence
reduces by up to half at one year.
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Mechanism
Psychological • Weak evidence of lesion
location • High rates in many medical
illnesses • Treatment effects, are not
very convincing • Loss and obvious
psychological mechanisms • Loss of role, independence,
future effects
Physical• High prevalence of
depression in stroke • Frontal striatal mechanism • Lesion location, head of
caudate, frontal akinesis etc • Differential response to
noradrenergic anti depressants
• Occurs in anosognosia
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Post stroke depression treatment
Psychological • Firstly depression post
stroke is clearly both psychological and biological
• Rehabilitation is crucial• Pain management • Social supports• Encourage independence
again, sense of future hope
Pharmacological• Good evidence for SSRIs
post stroke• Suggestion that they may
prevent depression post stroke and improve rehabilitation outcomes.
• Cochrane database reviews do not give clear outlines for any intervention
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Post stroke mania
• Rare 1-5% prevalence • Classically non dominant temporal lobe • However this is a non robust finding • Increased rate in BPAD patients • Concept of manic defence for exams• Treatment with antipsychotics/mood
stabilisers (note increased risk of CVA with anti psychotics and dementia)
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Post stroke apathy
Apathy • Absence of concern about the
environment and self• Little interest in doing things • Frontal type initiation, not
uncommon in stroke • Look at lesion location,
frontal? • Trial of ADTs anyway?• Some suggest that
noradrenergic and or stimulants more effective
Depression• nearly always has features
of apathy • Distinction difficult• Generally core cognitions
will distinguish
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Post stroke anxiety disorders
• 20% of post stroke patients. • GAD and panic • No clear evidence about what treatments are
best.• Frequently interlinked with depression
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Post stroke catastrophic reactions
• Up to 19% post stroke • Associated with basal ganglia lesions and
frontal lesions• Outbreak of severe distress when unable to
perform simple tasks secondary to new disability.
• Release phenomena commonly
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Hyperemotionalism
• Pathological affect • Emotional lability • Inability to control affect in response to
emotional or other stimuli • Frequently seen as part of a pseudobulbar
affect. • Some evidence for SSRIs (weak-case series
data)
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Psychosis post stroke
• Allegedly very rare in longitudinal case series with prevalence below 1%
• I doubt this and would suggest that it depends on how long the psychosis must last to be identified, certainly stroke is not uncommonly associated with delirium and this frequently is associated with psychosis.
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ACAM anuerysm
Can cause a WKSSame structures as affected in Wernick’e anatomically
Patients can end up profoundly amnestic, with a degree of confabulation from disruption of thalamic connections.
Generally seen post SAH/neurosurgery.
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Hypoxic ischemic encephalopathyAny age Most commonly describe in children
Also adults how suffer pump failure/global hypoperfusion/hpoxia/CO poisoning
Selective hippocampal loss and watershed infarcts, vulnerable areas
Global cognitive problems but classically amnestic due to hippocampal damage.
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Head of the caudate lesion
In this example bilateral
Classically associated with outflow problems from basal ganglia to frontal cortices
“akinetic mutism”
Can mimic catatonia but acuity of onset is classical.
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Bilateral thalamic damage
Can occur in general from embolic causes (rare)
When it does occur, prominent psychiatric features can result of disorientation, impaired memory, visual hallucinosis and longer term amnestic type state. Diencaphalic amnesia
Can also be similar to bilateral caudate problems.
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Bilateral occipital/parietal stroke
In general hospital, most commonly seen post CABG
Hypoperfusion injury or embolic
Can have a very odd presentation and frequently the team seek psychiatric opinion.
Generally has features of cortical blindness and visuospatial integration problems
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Conclusion
• Stroke is very common• Significantly complicated by psychiatric
disturbance• Need to consider physical rehab, psychiatric and
psychological aspects • Sometimes a trial of treatment when things are
not clear is a valid option. • Remember language disturbance may make
diagnosis difficult