The National Academy of Sciences, India - Section … Nomination Book 2016...The National Academy of...

CONFIDENTIAL (For use of Fellows of the Academy only)

The National Academy of Sciences, India

NOMINATIONS Valid for Consideration for Election to

Fellowship – 2019

Section of Biological Sciences BOOK - II

ANIMAL SCIENCES (Structural, Developmental, Functional, Genetical, Ecological,

Behavioural, Taxonomical and Evolutionary Aspects)

MEDICAL & FORENSIC SCIENCES

(Basic and Clinical Medical Sciences, Pharmacology, Anthropology, Psychology and Forensic Sciences, Human genetics, Reproduction

Biology, Neurosciences, Molecular Medicine)

5, Lajpatrai Road, Prayagraj-211002

The National Academy of Sciences, India

NOMINATIONS Valid for Consideration for Election to

Fellowship – 2019

Section of Biological Sciences BOOK - II

CONTENTS

ANIMAL SCIENCES 290 - 336 (Structural, Developmental, Functional, Genetical, Ecological, Behavioural, Taxonomical and Evolutionary Aspects)

MEDICAL & FORENSIC SCIENCES 337 - 442 (Basic and Clinical Medical Sciences, Pharmacology, Anthropology, Psychology and Forensic Sciences, Human genetics, Reproduction Biology, Neurosciences, Molecular Medicine)

5, Lajpatrai Road, Prayagraj-211002

(I)

ANIMAL SCIENCES

ACHAMVEETTIL, Gopalakrishnan 309

AGRAWAL, Nirupama 324

ANILKUMAR, Thapasimuthu Vijayamma 290

BANDYOPADHYAY, Probir Kumar 310

BHADRA, Anindita 298

BHADURY, Punyasloke 311

BHATTA, Raghavendra 299

CHATTOPADHYAY, Pronobesh 291

CHATURVEDI, Vinita 292

CHAUBE, Shail Kumar 293

CHAUHAN, Manmohan Singh 312

DAS, Manoj Kumar 325

DEB, Rajib 300

DINESH, Diwakar Singh 313

GARG, Lalit Chander 301

GUPTA, Neelima 314

HEGDE, Nagendra Ramachandra 302

HUSSAIN, Syed Ainual 326

JADHAO, Arun Govindraoji 332

JOSHI, Prakash Chandra 303

KAMARAJU, Raghavendra 333

KAR-CHOWDHURI, Debapratim 334

KRISHNAMOORTHY, Venkataraman 315

KUMAR, Pradeep G. 316

KUMAR, Vinod 294

MADAN, Taruna 304

MAZUMDER, Shibnath 305

MISRA, Aditya Kumar 327

MONDAL, Sukanta 306

MUKHERJEE, Srabani 295

MUKHOPADHYAY, Arnab 317

NALLUR, Ramachandra Basappa 318

NAUTIYAL, Prakash 296

PETER, M.C. Subhash 319

PRAKASH, Soam 335

RAISUDDIN, Sheikh 328

RAMESH, Saraf Rajagopalaiahsetty 320

ROY, Bishnupada 321

ROY, Jagat Kumar 336

SHARMA, G. Taru 329

SINGH, Raj Kumar 307

SINHA, Ravindra Kumar * 322

SUBBIAH, Poopathi 330

TRIPATHI, Bhupendra Nath 331

TRIVEDI, Sunil Prakash 297

YADAV, Rajpal Singh 308

YENUGU, Suresh 323

MEDICAL & FORENSIC SCIENCES

AFZAL, Mohammad 337

AHMAD, Farhan Jalees 361

BAJPAI, Minu 385

BAL, Chandra Sekhar 386

BALASUBRAMANYAM, Muthuswamy 362

BANERJEE, Monisha 410

BANERJEE, Soma 387

BARAL, Rathindranath 411

BARTHWAL, Manoj Kumar 338

BHADADA, Sanjay Kumar 339

BHARTI, Alok Chandra 363

BHATTACHARYYA, Maitree 426

BHUMA, Vengamma 388

CHAKRABARTI, Sasanka 389

CHAKRABARTI, Subhabrata 427

CHANDAK, Giriraj Ratan 428

CHANDRA, Amar Kumar 340

CHANDRA, Poodipedi Sarat 364

CHATTOPADHYAY, Debprasad 429

CHILAKAPATI, Murali Krishna 341

CHIPLUNKAR, Shubhada Vivek 390

CHOWDHARY, Anuradha 365

COLAH, Roshan Behram 430

DAS SARMA, Jayasri 366

DAS, Kusal Kanti 412

DAS, Madhusudan 367

DAS, Nilay Kanti 391

DAS, Satya Narayan 431

DAS, Sujata 342

DASH, Debabrata 392

DEEPAK, Kishore Kumar 393

DIXIT, Madhulika 368

DUTTA, Ranjna 413

DUTTA, Shanta 343

GANGADHAR, Bangalore Nanjundaiah 414

GARG, Pankaj 415

GARG, Prashant 369

GHATAK, Ashim 416

GHOSH, Deepa 394

GOEL, Rajesh Kumar 344

GUPTA, Ritu 345

GUTTI, Ravi Kumar 346

HALDER, Ashutosh 432

HANUMANTHAPPA, Krishna Prasad 433

HARINARAYAN, Chittari Venkata 395

HUSAIN, Nuzhat 434

(II)

JAIN, Amita 347

KAKKAR, Poonam 435

KANT, Ravi 348

KANT, Surya 370

KAPAETTU, Satyamoorthy 349

KAR, Shantanu Kumar 436

KATARE, Om Prakash 417

KAUR, Indu Pal 396

KESAVADAS, Chandrasekharan 371

KULKARNI, Mahesh Jagdish Rao 418

KUMAR, Rajeev 419

KUMAR, Rakesh 397

MAHDI, Abbas Ali 372

MAHESHWARI, Monika 398

MISHRA, Akhilesh Chandra 399

MISHRA, Amit Kumar 400

MISHRA, Prabhat Ranjan 420

MISHRA, Pradyumna Kumar 373

MISRA, Ramnath 437

MOHANAN, Parayanthala Valappil 374

NAMPERUMALSAMY, Venkatesh Prajna 421

NANDINENI, Madhusudan Reddy 350

NATH, Gopal 401

NEGI, Vir Singh 375

NEINIWAL, Sanjeev Kumar 376

PANDIT, Lekha 351

PARVEZ, Suhel 377

PATI, Sanghamitra 352

PATURU, Kondaiah 438

PAUL, Jaishree 422

PRASAD, Kashi Nath 378

RAJAMMA, Usha 402

RAJKUMAR, Hemalatha 379

RAMACHANDRAN, Balaraman 403

RANA, Surinder Singh 404

REDDY SHETTY, Prakasham 439

RISHI, Praveen 353

ROY, Tara Sankar 354

SADAKSHARAM, Jayachandran 423

SAGAR, Rajesh 405

SAXENA, Sandeep 406

SAXENA, Sunita 380

SENGUPTA, Amitava 355

SENGUPTA, Sharmila 407

SHARMA, Aman 440

SHARMA, Jai Bhagwan 408

SINGH, Sarman 356

SINGH, Sunit Kumar 441

SINHA, Sukesh Narayan 381

SOUNDARAPANDIAN, Kannan 424

SRINIVAS, Priya 357

SRINIVASAN, Narayanan 358

SRIVASTAVA, Achal Kumar 382

SRIVASTAVA, Deep Narayan 409

SULTANA, Sarwat 383

TANDON, Salil 425

TIWARI, Rajnarayan Ramshankar 359

TOTEJA, Gurudayal Singh 442

TRIPATHI, Manjari 360

VERMA, Mahesh 384

(III)

290

ANIMAL SCIENCES (Structural, Developmental, Functional, Genetical, Ecological,

Behavioural, Taxonomical and Evolutionary Aspects)

ANILKUMAR, T.V. (b 1961), Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram-695012

Member of the NASI: Yes (YON 2019, Animal Sciences)

Dr. TV Anilkumar is a veterinarian specialized in Toxicologic Pathology and Laboratory Animal Medicine. He has completed MSc (Experimental Pathology and Toxicology) and PhD (Pathology) of the University of London at the Imperial College School of Medicine (Hammersmith). Currently, he is a Scientist-G at the Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Thiruvananthapuram, an institute of national importance under the Government of India. He heads the Division of Experimental Pathology, which includes a Histopathology Laboratory that functions on par with international standards (ISO 17025) for testing and evaluation of biomaterials and biomedical devices. Dr Anilkumar pioneered the use of porcine cholecyst-derived extracellular matrix for regenerative medicine applications and invented a non-detergent and non-enzymatic technique for preparing tissue engineering scaffolds. When used for graft-assisted healing, the scaffold induces faster wound healing with minimal scarring, apparently by promoting a tissue remodelling reaction mediated by M2-macrophage and type-2 helper T-lymphocytes. The technology has now been transferred to M/s Alicorn Medical Private Limited, a start-up firm incubated in TIMED at the technology incubation facility of SCTIMST. Prototype of a wound healing matrix, identified as ‘Cholederm’ has been prepared. Dr Anilkumar has 60 peer reviewed journal articles, an American patent and an Irish patent. He is the President of the Indian College of Veterinary Pathologists and Past President of the Asian Society of Veterinary Pathology.

Proposer: Dr Oommen V. Oommen, Seconder: Dr. R. Prakashkuma

Ten Best Publications:

1. Anilkumar TV, Sarraf CE, Hunt T, Alison MR (1992). The nature of cytotoxic drug-induced cell death in murine intestinal crypts. British Journal of Cancer, 65 (4): 552-558. (if=5.922, ci=90)

2. TV Anilkumar, CE Sarraf, MR Alison (1992). The biology and pathology of programmed cell death (apoptosis). Veterinary and Human Toxicology, 34 (3): 251-254. (if=2.010, ci=23)

3. Anilkumar TV, M Golding, RJ Edwards, EIN Lalani, CE Sarraf, MR Alison (1995). The resistant hepatocyte model of carcinogenesis in the rat: the apparent independent development of oval cell proliferation and early nodules. Carcinogenesis, 16 (4): 845-853. (if=5.334, ci=44)

4. Burugapalli K, Anilkumar T (joint first author), Chan JCY, Yao L, Brody S, Kelly JL, Pandit A (2007). Scaffold with a natural mesh-like architecture: isolation, structural, and in vitro characterization. Biomacromolecules, 8(3):928-936. (if=5.246, ci=38)

5. Revi, D, Vineetha VP, Muhamed J, Rajan A, Anilkumar TV (corresponding author) (2013). Porcine cholecyst–derived scaffold promotes full-thickness wound healing in rabbit. Journal of Tissue Engineering ;4:2041731413518060. doi: 10.1177/2041731413518060.(if=2.683, ci=24)

6. Muhamed J, Deepa Revi, Roy Joseph, Anilkumar T (corresponding author) (2013). Phenotypic modulation of cell types around implanted polyethylene terephthalate fabric in rabbit muscle. Toxicologic Pathology, 41(3):497-507. (if=1.966, ci=8)

7. Anilkumar TV (corresponding author), VP Vineetha, D Revi, J Muhamed, A Rajan (2014). Biomaterial properties of cholecyst‐derived scaffold recovered by a non‐detergent/enzymatic method. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 102(7):1506-16. doi: 10.1002/jbm.b.33131. (if=3.373, ci=23)

8. Muhamed J, Revi D, Rajan A, Geetha S, Anilkumar TV (corresponding author) (2015) Biocompatibility and Immunophenotypic Characterization of a Porcine Cholecyst-derived Scaffold Implanted in Rats. Toxicologic Pathology, 43(4): 536-45. doi: 10.1177/0192623314550722. (if=1.966, ci=13)

9. Muhamed J, Revi D, Rajan A, Anilkumar T (corresponding author) (2015). Comparative local immunogenic potential of scaffolds prepared from porcine cholecyst, jejunum, and urinary bladder in rat subcutaneous model.J Biomed Mater Res B Applied Biomaterials, 103(6):1302-11. doi: 10.1002/jbm.b.33296. (if=3.373, ci=7)

10. Nair RS, Ameer JM, Alison MR, Anilkumar TV (corresponding author) (2017). A gold nanoparticle coated porcine cholecyst-derived bioscaffold for cardiac tissue engineering. Colloids Surf B Biointerfaces, 157:130-137. doi: 10.1016/j.colsurfb.2017.05.056. (if=4.294, ci=9)

291

CHATTOPADHYAY, PRONOBESH (b 1975), Scientist, Defence Resaerch laboratory, DRDO, Tezpur-784001, Assam

Member of the NASI: No (YON 2019, Animal Sciences)

Dr. P. Chattopadhyay's major achievements are a development of Chilli Grenade- used for the mob dispersal. In this regard, a number of trials were conducted with different police forces i.e. CRPF, RAF, NSG etc which are and now inducted to the different state police forces. The effects on animals eye, respiration system, and safety aspects were established is an alternate product and more effective than tear gas which is carcinogenic. This product technology already transferred to three industries for large production. Dr. P. Chattopadhyay also put his efforts to many contributions to overcome a real challenge in jungle operation of forces and snake repellant is one of the important products developed by him. Snake repellant is widely used by Indian Forces and effective against poisonous and nonpoisonous snakes. Also, this product technology already transferred to industry for large production. He also contributed for glacial terrain research, especially protection of Ultraviolet B and C protection. The formulation is stable at -50C and SPF 50+. The product is safe, cleared the regulatory requirement as per government norms and under in active consideration for deployment in Indian Forces. Dr.P. Chattopadhyay has more than 100 publications, 2 book chapters, more than 10 patent filed and trademark for 3 products.

Proposer: Dr. Arun Bandopadhyay, Seconder: Dr. Sib Sankar Roy


1. Krishnatreyya H, Hazarika H, Saha A, Chattopadhyay P. 2018. Fundamental pharmacological expressions on ocular exposure to capsaicin, the principal constituent in pepper sprays. Scientific Report 8(1): 12153. doi: 10.1038/s41598-018-30542-2. (if=4.122, ci=05)

2. Nehra S, Bhardwaj V, Bansal A, Chattopadhyay P, Saraswat D. 2017. Nanocurcumin-pyrroloquinoline formulation prevents hypertrophy-induced pathological damage by relieving mitochondrial stress in cardiomyocytes under hypoxic conditions. Experimental Molecular Medecine. 49(12):e404. doi: 10.1038/emm.2017.199 (if=5.584, ci=01)

3. Barua, S., Gogoi, B., Aidew, L., Buragohain, A.K., Chattopadhyay, P., Karak, N., 2015c. Sustainable Resource based Hyperbranched Epoxy Nanocomposite as an Infection Resistant, Biodegradable, Implantable Muscle Scaffold. (if=6.140, ci=07)

4. Bora NS, Mazumder B, Mandal S, Patowary P, Goyary D, Chattopadhyay P, Dwivedi SK. 2019. Amelioration of UV radiation-induced photoaging by a combinational sunscreen formulation via aversion of oxidative collagen degradation and promotion of TGF-β-Smad-mediated collagen production. (if=3.869, ci=06)

5. Das, B., Chattopadhyay, P., Mishra, D., Maiti, T.K., Maji, S., Narayan, R., Karak, N., 2013b. Nanocomposites of bio-based hyperbranched polyurethane/funtionalized MWCNT as non-immunogenic, osteoconductive, biodegradable and biocompatible scaffolds in bone tissue engineering. J. Mater. Chem. B 1, 4115. doi:10.1039/c3tb20693a. (if=4.776, ci=06)

6. Patowary P, Pathak MP, Zaman K, Raju PS, Chattopadhyay P. 2017. Research progress of capsaicin responses to various pharmacological challenges. Biomed Pharmacother. 96:1501-1512. doi: 10.1016/j.biopha.2017.11. (if=3.457, ci=07)

7. Chattopadhyay P, Dhiman S, Devi K, Banerjee S, Rabha B, Chaurasia A, Veer V. 2013. Ultra low concentration deltamethrin loaded patch development and evaluation of its repellency against dengue vector Aedes (S) albopictus. (if=3.490, ci=08)

8. Krishnatreyya H, Hazarika H, Saha A, Chattopadhyay P. 2018. Capsaicin, the primary constituent of pepper sprays and its pharmacological effects on mammalian ocular tissues. Eur J Pharmacol. 2018. 819:114-121. doi: 10.1016/j.ejphar.2017.11.04. (if=3.044, ci=05)

9. Banerjee, S., Chattopadhyay, P., Ghosh, A., Pathak, M.P., Gogoi, J., Veer, V., 2014c. Protection by a transdermal patch containing eserine and pralidoxime chloride for prophylaxis against (±)-Anatoxin A poisoning in rats. Eur. J. Pharm. Sci. 56, 28–36. doi:10.1016/J.EJPS.2014.01.013. (if=3.773, ci=05)

10. Upadhyay, A., Chattopadhyay, P., Goyary, D., Mazumder, P.M., Veer, V., 2013b. Eleutherine indica L. accelerates in vivo cutaneous wound healing by stimulating Smad-mediated collagen production. J. Ethnopharmacol. 146, 490–494. doi:10.1016/j.jep.2013.01.012.. (if=3.155, ci=20)

292

CHATURVEDI, VINITA (b 1963), Senior Principal Scientist, CSIR-Central Drug Research Institute. Lucknow


Dr. Vinita Chaturvedi developed a convenient in-vitro surrogate screen by utilising Fast-grower,non-hazardous Mycobacterium smegmatis to short-list molecules active against slow-grower,hazardous MDR-Mtb. The screen showed 100% specificity vis-à-vis MDR-Mtb(T5)and has been replicated by other laboratories across the world. She established Mtb bacteraemia in immune-competent mice to short-list in-vivo actives. Multiplication/ killing(after drug treatment) of Mtb in the blood and routinely investigated tissues(lung/spleen/liver)were found comparable(T2). Since, evaluation of drug efficacy on bacteraemia will, avoid animal sacrifice, help to determine bactericidal and anti-relapse efficacies in same set of animals and reflect overall therapeutic outcome in whole body. Towards anti-TB drug discovery, her laboratory identified two new anti-TB leads- a synthetic molecule S006-830(T3,P8) and a herbal extract of Salicornia spp(P9[US Patent-7442393]-P19). S006-830 showed bactericidal activity in-vitro, ex-vivo (in infected mouse macrophages) and in vivo (in infected mice) models, inhibited growth of single/multi-drug (isoniazid/rifampicin/both) resistant Mtb(T3). PK parameters revealed that S006-830 is a drug-like molecule. The more active S-enantiomer(S-S006-830) of the racemate (S006-830), in combination with Rifampicin killed 100% intracellular Mtb in 8 days. S-S006-830 acts by a novel mechanism by targeting FabG4(β-ketoacyl CoA reductase) of Mtb cell membrane(CM) which is involved in the production of mycolic acids(T1). She also characterised antigens of M habana a candidate TB vaccine identified by CSIR-CDRI. Triton-X-114-soluble antigens(proteins) of Peripheral CM protected Mtb infected mice(T8,T9), whereas Triton-X-114-insoluble antigens(LAM,LM,PIMs) of Integral CM detected antibodies in the clinical samples(serum/body fluids) of extra-pulmonary TB patients(T7).

Proposer: Prof. Tapas K. Kundu, Seconder: Prof. V.P. Kamboj


1. Singh P, Kumar SK, Maurya VK, Mehta BK, Ahmad H, Dwivedi AK, Chaturvedi V*, Thakur TS, Sinha S. 2017. S-enantiomer of the anti-tubercular compound S006-830 complements activity of frontline TB drugs and targets biogenesis of Mycobacterium tuberculosis cell envelope.ACS Omega, 2(11): 8453-8465. (if=Not yet known., ci=2)

2. Dwivedi R, Singh S, Trivedi P, Chaturvedi V*. 2017. Multiplication of Mycobacterium tuberculosis in Peripheral Blood of Mice and Effect of Anti- tubercular Drugs on Bacteremia. Lett Drug Design Discovery, 14(9), 1048-1052. (if=1.17, ci=NIL)

3. Singh P, Manna SK, Jana AK, Saha T, Mishra P, Bera S, Parai MK, Kumar M SL, Mondal S, Trivedi P, Chaturvedi V, Singh S, Sinha S, Panda G. 2015. Thiophene containing Trisubstituted methanes [TRSMs] as identified lead against Mycobacterium tuberculosis.Eur J Medici Chem, 95 357- 368. (if=3.499, ci=7)

4. Singh S, Dwivedi R and Chaturvedi V*. 2012. Influence of vehicles used for oral dosing of test molecules on the progression of Mycobacterium tuberculosis infection in mice.Antimicrob Agents Chemoth 56: 6026-6028. (if=4.84, ci=5)

5. Chaturvedi V*, Dwivedi N, Tripathi RP, Sinha S. 2007. Identification and evaluation of Mycobacteriu smegmatis as a possible surrogate screen for selecting molecules active against multi-drug resistant M tuberculosis.J Gen Appl Microb 53, 333-337. (if=1.00, ci=79)

6. Chaturvedi V, Girdhar BK, Sengupta U, Sinha S. 2007.Semi-quantitative detection of Mycobacterium leprae antigens in skin scrapings: Suitability as a laboratory aid for field diagnosis of leprosy.Trans Royal Soc Trop Med Hyg, 101, 699-706. (ci=3)

7. Chaturvedi V*, Gupta HP. 2002. Evaluation of integral membrane antigens of Mycobacterium habana for serodiagnosis of extrapulmonary tuberculosis : Association between levels of antibodies and Mycobacterium tuberculosis antigens. FEMS Immunol MED Microbiol 33, 1-7. (if=2.684, ci=13)

8. Chaturvedi V*, Srivastava A, Gupta HP and Srivastava BS. 1999. Protective proteins of Mycobacterium habana are distributed between peripheral and integral compartments of plasma membrane. A study in experimental tuberculosis of mouse. Vaccine 17: 2882-2887. (if=3.492, ci=13)

9. Chaturvedi V*, Jyoti D Srivastava S and Gupta HP. 1999. Secretory proteins of Mycobacterium habana induce a protective response against experimental tuberculosis.FEMS Immunol Med Microbiol 26(2): 143-151. (if=2.684, ci=7)

10. Gupta I, Jain A, Singh NB, Chaturvedi V and Agarwal SK. 1998. Role of antigen specific circulating immune complexes in diagnosis of tuberculosis.Int J Tuber Lung Dis 2(6); 456-461. (if=2.61, ci=11)

293

CHAUBE, SHAIL KUMAR (b 1968), Professor, Department of Zoology, Institute of Science, BHU, Varanasi


Prof. Shail K Chaube has made significant contributions in the field of oocyte physiology during last 25 years to enrich scientific knowledge in a greater detail so that the oocyte quality could be improved for various Assisted Reproductive Technology programs. His high quality research enabled him to publish over 100 research papers in international journals of repute. He has reported that the cAMP drop is prerequisite for meiotic resumption from diplotene arrest. He explained why diplotene-arrested immature oocytes do not extrude first polar body under in vitro culture conditions and demonstrated the beneficial impact of a moderate level of Reactive Oxygen Species (ROS) during meiotic maturation. He has made a significant breakthrough by reporting that the premature release of insufficient amount of calcium from internal stores induces maturation promoting factor (MPF) destabilization that triggers spontaneous abortive activation after ovulation and deteriorate oocyte quality in several mammalian species including humans. He proposed that ROS acts as signal molecules and modulate oocyte physiology including meiotic cell cycle progression arrest, apoptosis, necroptosis and autophagy in mammals. He reported that the presence of encircling granulosa cells could protect ROS-mediated deterioration of oocyte quality under in vitro culture conditions. The germ cell depletion from ovary is one of the major issues since it directly affects reproductive potential in mammals. He proposed that stress-mediated generation of ROS,ROS-mediated early germ cell depletion and deterioration in oocyte quality causes for reduced reproductive potential, rapid decline of several precious mammalian species from the globe.

Proposer: Dr. Satish Kumar Gupta Seconder: Prof. M.K. Thakur


1. Tripathi A., Premkumar K.V. and Chaube S.K. (2010) Meiotic cell cycle arrest in mammalian oocyte. J Cell Physiology 223; 592-600(if=3.923, ci=143)

2. Chaube, S.K. Prasad P.V., Thakur S.C. and Srivastava T.G. (2005) Hydrogen peroxide modulates meiotic cell cycle and induces morphological features charecteritics of apoptosis in rat oocytes cultured in vitro. Apoptosis, 10: 863-875. (if=3.94, ci=98)

3. Pandey A.N., Tripathi A., Premkumar K.V., Shrivastav T.G. and Chaube S.K. (2010) Reactive Oxygen and Nitrogen Species during Meiotic Resumption from Diplotene Arrest in Mammalian Oocytes. J. Cell. Biochem. 111: 521-8. (if=2.96, ci=78)

4. Tiwari M, Prasad S, Tripathi S, Pandey AN, Singh AK, Shrivastav TG, Chaube SK (2015) Apoptosis in Mammalian Oocytes: A Review. Apoptosis 20:1019–1025 (if=3.94, ci=70)

5. Tripathi A, Khatun S, Pandey A.N., Mishra S. K., Chaube R, Shrivastav T.G., and Chaube S. K. (2009) Intracellular levels of hydrogen peroxide and nitric oxide in oocyte at various stages of meiotic cell cycle and apoptosis. Free Radical Research, 43, 287-294. (if=3.038, ci=58)

6. Prasad S, Tiwari M, Tripathi A, Pandey AN, Shrivastav TG and Chaube SK. (2016). Impact of stress on female reproductive outcome. J Biomed Sci.: 23;36 (1-5). (if=3.46, ci=47)

7. Chaube, S.K. Prasad P.V., Thakur S.C. and Srivastava T.G. (2005) Estradiol protects clomiphene citrate induced apoptosis in rat ovarian follicles and superovulated cumulus oocyte complexes. Fertility Sterility; 84; 1163-1172. (if=4.08, ci=38)

8. Prasad S, Tiwari M, Tripathi A, Pandey AN, Chaube SK (2015) Changes in levels of signaling molecules and maturation promoting factor during meiotic resumption from diplotene and metaphase-II arrest in rat oocytes. Cell Biol. Intl 39; 759-769. (if=1.94, ci=34)

9. Tripathi A, Chaube SK (2012) High level of cytosolic free calcium signals apoptosis through the mitochondria-caspase mediated pathway in rat eggs cultured in vitro. Apoptosis 17, 439-448. (if=3.94, ci=36)

10. Prasad S, Tiwari M, Koch B and Chaube SK (2015) Morphological, cellular and molecular changes during postovulatory egg aging in mammals. J Biomed Sci 2015 22:36 (if=3.46, ci=30)

294

KUMAR, VINOD (b 1956), Professor, Department of Zoology, University of Delhi, Delhi

Member of the NASI: No

(YON 2019, Animal Sciences)

Professor Vinod Kumar is a well-established investigator in the area of Photobiology and Chronobiology/ Behavioral Neuroscience/ Physiological Ecology. His research programs on circadian and photoperiodic physiology of Palaearctic-Indian migratory are pioneering. His research has, for the first time (i) provided evidence for molecular differences in the hypothalamic control between spring and autumn migration; (ii) transcriptome-wide changes in the hypothalamus, liver and gonads have revealed molecular differences in photoperiod-induced seasonal life-history states; (iii) unravelled transcriptional basis of circadian rhythm dependence of seasonal phenotypes in migratory birds; (iv) provided evidence for the adaptation of gonadal, metabolic and oxidative phosphorylation pathway(s) at gene levels to seasonal metabolism; (v) showed high temperature affects both the timing and duration of phenologies linked with spring migration and reproduction in migratory buntings; (vi) availability of food at “right time”, not the “right quantity or quality” alone, was critical for optimal reproductive performance; (vi) There can be independent circannual timing strategies, with females sharing a greater role in defining the reproductive season in relation with the environment; (vii) Pineal melatonin secretion is circadian in nature and the information acquired in-vivo can be recalled in-vitro even after a few days of constant conditions in songbirds. His research, mostly conceptual in nature, contributes to the understanding that in a shared ecological niche, a flexible but self-sustained and differentially responsive timekeeping system sensitive to multiple environmental cues enables individuals and species to program their physiological activities along the course of day and/ or of the year in an adaptive sense.

Proposer: Prof. Jitendra P. Khurana, Seconder: Prof. Yogendra Singh


1. Aakansha Sharma, Devraj Singh, Shalie Malik, Neelu JainGupta, Sangeeta Rani and Vinod Kumar (2018) Difference in control between spring and autumn migration in birds: Insight from seasonal changes in hypothalamic gene expression in captive buntings. Proceedings of Royal Society B 285: http://dx.doi.org/10.1098/rspb.2018.1531 (if=IF: 4.847)

2. Devraj Singh, Vivek Swarup. Hiep Le and Vinod Kumar (2018) Transcriptional signatures in liver reveal metabolic adaptations to seasons in migratory blackheaded buntings. Frontiers in Physiology doi: 10.3389/fphys.2018.01568 (if=4.134)

3. S. K. Tahajjul Taufique, Abhilash Prabhat and V. Kumar (2018) Illuminated night alters hippocampal gene expressions and induces depressive-like response in diurnal corvids. European J. Neuroscience doi: 10.1111/ejn.14157 (if=2.941)

4. Neelu Anand Jha and Vinod Kumar (2017) Effect of no-night light environment on behaviour, leanring performance and personality in zebra finches. Animal Behaviour 132: 29-47. (if=3.068)

5. Devraj Singh, Amit Kumar Trivedi, Sangeeta Rani, Satchidananda Panda and Vinod Kumar (2015) Circadian timing in central and peripheral tissues in a migratory songbird: Dependence on annual life-history states. The FASEB Journal doi:10.1096/fj.15-275339.(if=5.595)

6. Amit Kumar Trivedi, Jayant Kumar, Sangeeta Rani and Vinod Kumar (2014) Annual life history-dependent gene expression in the hypothalamus and liver of a migratory songbird: Insights into the molecular regulation of seasonal metabolism. Journal of Biological Rhythms 29: 332-345. (if=3.906)

7. J. Singh, P. Budki, S. Rani and V. Kumar (2012) Temperature alters the photoperiodically controlled phenologies linked with migration and reproduction in a night-migratory songbird. Proceeding of Royal Society. B. 279: 509-515 (IF 5.064). (if=4.847)

8. J. Singh, P. Budki, S. Rani and V. Kumar (2012) Functional similarity in relation to the external environment between circadian behavioral and melatonin rhythm in the subtropical Indian weaver bird. Hormones and Behavior doi:10.1016/j.yhbeh.2012.01.015.(if=4.418)

9. R. Brandstaetter, V, Kumar, U. Abraham and E. Gwinner (2000) Photoperiodic information acquired and stored in vivo is retained in vitro by a circadian oscillator, the avian pineal gland. Proc. Natl. Acad. Sci. USA, 97: 12324-12328. (if=9.504)

10. V. Kumar and B. K. Follett (1993) The circadian nature of melatonin secretion in Japanese quail (Coturnix coturnix japonica). J. Pineal Res. 14: 192-200. (if=11.613)

295

MUKHERJEE, SRABANI (b 1964), Scientist F National Institute for Research in Reproductive Health (ICMR), Mumbai


PCOS, a common heterogeneous endocrinopathy, is a major cause of anovulatory infertility with metabolic repercussions and increasing prevalence in Indian women is an important public health concern. Dr. Mukherjee has been focused towards elucidating the complex pathophysiology of PCOS using multipronged approach involving genomics, proteomics and epigenetics, over last 15 years. She has developed a mouse model by neonatal estrogenization, which mimics PCOS-like features including follicular growth arrest, premature luteinisation, prominent cystic follicles demonstrating increased apoptosis via the mitochondrial pathway in granulosa cells, and infertility (Shinde, 2018). Extended studies on same model have shown global epigenetic alterations in ovary evidenced by increased 5hmC and decreased 5mC content. She has elucidated changes in epigenetic signatures through global methylation and genome-wide methylation studies in granulosa cells of women undergoing IVF that may yield putative markers which can be therapeutically targeted (Sagvekar, 2017, 2019). Her studies on differential proteomics of follicular fluid identified altered expression of several vital proteins indispensable for follicular growth, which partially explains the aberrant folliculogenesis in PCOS. She observed for the first time dysregulation of proteins involved in formation and expansion of COC matrix which leads to poor oocyte quality reported in PCOS women(Ambekar,2015). Further investigations also revealed compromised angiogenesis in PCOS follicle (Patil, 2019). She is also working towards delineating the genetic predisposition profile of Indian PCOS women. Her candidate gene studies reported differences in genetic pathomechanism between lean and obese women with PCOS, which emphasize the necessity of phenotypic subgrouping of PCOS women (Mukherjee. 2009; Dadachanji, 2015).

Proposer: Dr. Smita D. Mahale, Seconder: Dr. V. P. Kamboj


1. Mukherjee S, Shaikh N, Khavale S, Shinde G, Meherji P, Shah N, Maitra A. (2009) Genetic variation in exon 17 of INSR is associated with insulin resistance and hyperandrogenemia among lean Indian women with polycystic ovary syndrome. Eur J Endocrinol. May;160(5):855-62. (if=3.867, ci=75)

2. Ambekar AS, Nirujogi RS, Srikanth SM, Chavan S, Kelkar DS, Hinduja I, Zaveri K, Prasad TS, Harsha HC, Pandey A, Mukherjee S. (2013) Proteomic analysis of human follicular fluid: a new perspective towards understanding folliculogenesis.. J of Proteomics. 87:68-77. (if=3.722, ci=62)

3. Shaikh N, Mukherjee A, Shah N, Meherji P, Mukherjee S. (2013) Peroxisome proliferator activated receptor gamma gene variants influence susceptibility and insulin related traits in Indian women with polycystic ovary syndrome. J Assist Reprod Genet. 30(7):913-21(if=2.788, ci=16)

4. Ambekar AS, Kelkar DS, Pinto SM, Sharma R, Hinduja I, Zaveri K, Pandey A, Prasad TS, Gowda H, Mukherjee S. (2015) Proteomics of follicular fluid from women with polycystic ovary syndrome suggests molecular defects in follicular development. J Clin Endocrinol Metab. 100(2):744-53. (if=5.789, ci=37)

5. Dadachanji R, Shaikh N, Khavale S, Patil A, Shah N, Mukherjee S (2015). PON1 polymorphisms are associated with PCOS susceptibility, related traits, and PON1 activity in Indian women with the syndrome. Fertil Steril.104(1):207-16. (if=4.803, ci=7)

6. Shaikh N, Dadachanji R, Meherji P, Shah N, Mukherjee S (2016). Polymorphisms and haplotypes of insulin-like factor 3 gene are associated with risk of polycystic ovary syndrome in Indian women. Gene. 577(2):180-6. (if=2.498, ci=13)

7. Sagvekar P, Mangoli V, Desai S, Patil A, Mukherjee S (2017) . LINE1 CpG-DNA hypomethylation in granulosa cells and blood leukocytes is associated with PCOS and related traits. J Clin Endocrinol Metab. 102(4):1396-1405 (if=5.789, ci=Nil)

8. Shinde G, Khavale s, Dadachanji R, D’Souza S, Nandedkar T, Mukherjee S. (2018). Estrogenized mouse model of PCO highlights mitochondrial pathway of apoptosis. Indian Journal of Experimental Biology. 56(05): 293-304 (if=1.475, ci=Nil)

9. Patil K, Yelamanchi S, Kumar M, Hinduja I, Prasad T, Gowda H, Mukherjee S (2019). Quantitative mass spectrometric analysis to unravel glycoproteomic signature of follicular fluid in women with polycystic ovary syndrome. PLoS One. April 4;14(4):e0214742(if=2.766, ci=Nil)

10. Sagvekar P, Kumar P, Mangoli V, Desai S and Mukherjee S. (2019). DNA Methylome Profiling of Granulosa Cells Reveals Altered Methylation in Genes Regulating Vital Ovarian Functions in Polycystic Ovary Syndrome. Clinical Epigenetics (in press). (if=6.091, ci=Nil)

296

NAUTIYAL, PRAKASH (b 1958), Professor, H.N.B. Garhwal University, Arinagar, UK


Prof. Prakash Nautiyal has made outstanding contributions to the biology of the Himalayan mahseer (A state fish of Jammu & Kashmir, Himachal Pradesh, Uttarakhand, and Arunachal Pradesh), related ecology and biodiversity of the Ganga (National river) system (Annexures I, II). During the past 38 years he has undertaken the following major research activities resulting in 128 original peer reviewed research papers in journals, proceedings and knowledge-based books, 2 reports and 10 books. His publications and curriculum vitae reveal excellent work on fisheries biology, population dynamics and related ecology of the Himalayan mahseer in uplands of the Ganga, facilitated by research projects from MoEF, DST, UCST, DCFR and work done for Doctoral degree under his supervision. This research was extended to the species of economic and conservation importance, as Reader at University of Allahabad, resulting in Doctoral degrees. His extensive work on community ecology of benthic diatoms and macroinvertebrates in rivers of Bundelkhand Plateau also lead to Doctoral degrees (Thesis Awarded 21). This and studies in Himalaya generated knowledge on longitudinal and spatial distribution of benthic communities and leading to Doctoral degrees addressing various ecological problems including biogeography. Later on he contributed to conservation biology of the endangered mahseer Tor putitora through research, as advisor to WWF (Reports) and Conservation Leadership Programme (2017) and as consultant to hydropower projects. He participated in the determination of e-flows for the Upper Ganga and Ramganga with WWF and IIT’s. This knowledge has been applied for remedying ill-effects of HEP on aquatic biodiversity.

Proposer: Prof. W.S. Lakra, Seconder: Prof. U.C. Srivastava


1. Nautiyal P, Mishra A S, Verma J & Agarwal A. 2017 River Ecosystems of Central Highland Ecoregion: Spatial distribution of benthic flora and fauna in the Plateau rivers (tributaries of the Yamuna and Ganga) in Central India. Aquatic Ecosystem Health & Management Society; 20:1-2, 43-58 doi 10.1080/14634988.2017.1296324 (if=1.033)

2. Wantzen, K. M., Ballouche, A., Longuet, I., Bao, I., Bocoum, H., Cisse´ f L., Chauhan, M., Girard, P., Gopal B., Kane A., Marchese M. R., Nautiyal P., Teixeiram, P., Zalewski, M., 2016 River Culture: an eco-social approach to mitigate the biological and cultural diversity crisis in riverscapes. Ecohydrology & Hydrobiology 16, 7-18. http://dx.do (if=1.592)

3. Gupta, N., Nautiyal, P, Borgohain, A., Sivakumar, K., Mathur, V., Chadwick, M. 2016 Catch-and-release angling as a management tool for freshwater fish conservation in India. Oryx, 50 (2)-250-256; Online 2014 doi:10.1017/ S0030605314000787. (if=1.91)

4. Nautiyal P, Nautiyal R, Semwal V P, Mishra A S, Verma J, Uniyal D P, Uniyal M, & Singh K R 2013 Ecosystem health indicators in the Ganga Basin (Uttarakhand, India): Biodiversity, spatial patterns in structure and distribution of benthic diatoms, macroinvertebrates and ichthyofauna. Aquatic Ecosystem Health & Management Society 16(4),362-373. h (if=1.041)

5. Nautiyal P 2013 A review on the art and science of the Indian mahseers (game-fish) in the 19th-20th century - road to extinction or conservation? Proc Natl Acad Sci India Sect. B Biol Sci. 84(2), 215-236. DOI: 10.1007/s40011-013-0233-3 (if=0.396)

6. Nautiyal P 2010 Food Chains of Ganga River Ecosystems in the Himalaya. Aquatic Ecosystem Health & Management Society, 13 (4), 362.-373. DOI: 10.1080/14634988.2010. (if=0.075)

7. Dinesh, K. Nandeesha, M. C. Nautiyal, P. and Aiyappa, P. 2010 Mahseers in India: A review with focus on conservation. Indian Journal of Animal Sciences (Supplement 1) 80(4), 26 – 38 (if=0.147)

8. Nautiyal P., Nautiyal R, Kala, K and Verma J 2004. Taxonomic richness in the diatom flora of Himalayan streams (Garhwal, India). Diatom 20, 123-132. https://doi.org/ 10.11464/diatom 1985.20.0_123 (if=Not known)

9. Nautiyal P, Kala Kavita and Nautiyal R 2004 A preliminary study of the diversity of diatoms in streams of the Mandakini basin (Garhwal Himalaya) pp. 235-269. In: Proceedings 17 Internat. Diatom Symp. Ottawa (M Poulin [ed.], Biopress Limited, Bristol. (if=IF not known)

10. Bhatt J P Nautiyal P & Singh H R 2000 Population structure of Himalayan Mahseer, A large cyprinid fish in the regulated foothill section of the river Ganga. Fisheries Research 44, 267-271 (if=IF not known)

297

TRIVEDI, SUNIL PRAKASH (b 1960), Professor, Department of Zoology, University of Lucknow, Lucknow226007.India


Dr. Sunil Prakash Trivedi, Professor of Zoology in University of Lucknow, has teaching and research experience of more than 28 years. He is consistently engaged in Fish Toxicology/ Toxicogenomics / Nutrigenomics involving identification of biomarkers and elucidation of molecular mechanisms under the exposure of different genotoxicants in fish. He has supervised 17 candidates for the award of Ph.D. degree. Most of them are well placed in State Universities: University of Lucknow, CSJM University, Kanpur, MJP Rohilkhand University, Bareilly; National Research Institutes like CSIR-IITR, Lucknow, National Disease Control Board, New Delhi, and Rajiv Gandhi Center for Biotechnology (DBT), Trivandrum. Dr. Trivedi has delivered more than 20 ‘Invited talks’ in national and International seminars/conferences and also contributed more than 65 research papers in peer reviewed journals, 20 Book Chapters, 18 edited books, and one text book, “Fundamentals of Toxicology” which he has co-authored. He has introduced Micronucleus test (MNT) and Chromosomal aberration test (CAT) among post-graduate students. Prof. Trivedi has completed one major research project funded by the UGC, New Delhi and recently he has been awarded “Center of Excellence in ‘Fish Nutrigenomics’ funded by the U.P. State Government. In recognition of his research and academic contributions, Prof. Trivedi was honored with fellowships and awards of several learned scientific bodies, viz., Academy of Science for Animal Welfare, The Zoological Society, Calcutta, Academy of Environmental Biology, Zoological Society of India, Bodh Gaya, Bioved Research Society, and Indian Academy of Environmental Sciences.

Proposer: Dr.Renu Tripathi, Seconder: Dr. Anuradha Dube


1. Atindra Kumar Pandey, Naresh S. Nagpure, Sunil P. Trivedi (2018) Genotoxicity assessment of pesticide profenofos in freshwater fish Channa punctatus (Bloch) using comet assay and random amplified polymorphic DNA (RAPD). Chemosphere 211 (2018) 316-323.(if=4.208, ci=1)

2. Yashika Awasthi, Arun Ratn, Rajesh Prasad, Manoj Kumar and Sunil P. Trivedi (2018). An in vivo analysis of Cr6+ induced biochemical, genotoxicological and transcriptional profiling of genes related to oxidative stress, DNA damage and apoptosis in liver of fish, Channa punctatus (Bloch, 1793). Aquatic Toxicology, 200, 158–167. DOI:10.1016/j.aquatox (if=4.129, ci=4)

3. Anubha Shukla and Sunil P. Trivedi (2018). An in vitro analysis of the rat C6 glioma cells to elucidate the linear alkylbenzene sulfonate induced oxidative stress and consequent G2/M phase cell cycle arrest and cellular apoptosis. Chemosphere 205 443-451. (if=4.208, ci=1)

4. Arun Ratn, Rajesh Prasad, Yashika Awasthi, Manoj Kumar, Abha Misra, and Sunil P. Trivedi (2018). Zn2+ induced molecular responses associated with oxidative stress, DNA damage and histopathological lesions in liver and kidney of the fish, Channa punctatus (Bloch, 1793). Ecotoxicology and Environmental Safety, 151, 10-20. (if=3.783, ci=3)

5. Shraddha Dwivedi, Manoj Kumar & Sunil P. Trivedi. (2017) Mitigating potential of Melissa officinale against As3+-induced cytotoxicity and transcriptional alterations of Hsp70 and Hsp27 in fish, Channa punctatus (Bloch). Environ Monit Assess (2017) 189:306 (if=1.804, ci=4)

6. Arun Ratn,Yashika Awasthi, Manoj Kumar, Sunil Kumar Singh, Renu Tripathi , Sunil P. Trivedi.(2017). Phorate induced oxidative stress, DNA damage and differential expression of p53, apaf-1 and cat genes in fish, Channa punctatus (Bloch, 1793). Chemosphere, 182, 382-391. (if=4.208, ci=7)

7. Atindra K Pandey, Naresh Sahebrao Nagpure, Sunil P Trivedi, Ravindra Kumar and Basdeo Kushwaha. (2011). “Profenofos induced DNA damage in freshwater fish, Channa punctatus (Bloch) as detected using alkaline single cell gel electrophoresis”. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, vol. 726, 209-214. (if=1.996, ci=45)

8. Kartik, R., Rao, C. V., Trivedi, S. P., Pushpangadan, P., & Reddy, G. D. (2010). Amelioration effects against N-nitrosodiethylamine and CCl4-induced hepatocarcinogenesis in Swiss albino rats by whole plant extract of Achyranthes aspera. Indian journal of pharmacology, 42(6), 370. (if=0.691, ci=30)

9. Kamlesh K. Yadav and Sunil P. Trivedi (2009). “Sublethal exposure of heavy metals induces micronuclei in fish, Channa punctata”. Chemosphere, 77, 1495-1500. (if=4.208, ci=72)

10. Yadav, K.K. And Trivedi, S.P. (2009). “Chromosomal aberrations in a fish, Channa punctata after in vivo exposure to three heavy metals”. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 678, 7-12. (if=1.996, ci=38)

298

BHADRA, ANINDITA (b 1977), Assistant Professor, Indian Institute of Science Education and Research, Kolkata


Immediately following her PhD, Anindita Bhadra has established her own independent research group to work on the Indian stray dog. The dog is far from an established model system but holds great promise. Dogs are everywhere, relatively easy to study, both in the lab and in the field, can be experimentally manipulated easily and are pretty good proxies for humans and other higher animals. Anindita and her students have measured the dog’s time-activity budgets, mortality rates, denning habits and mating seasonality. Through clever experiments they have shown that the dogs can be either social or solitary depending on the environment, that their preference for meat is not innate but has to be learned, that they show both parent-offspring conflict on the one hand and grandmotherly care on the other. They have recently obtained a counter-intuitive result – that mothers are more selfish in sharing food with their offspring when food is rich and more altruistic when food is poor. In the light of the parent-offspring conflict theory which guided their research however, this behaviour is indeed expected. She and her students have demonstrated that stray dogs quickly learn to distrust humans, and that they are more likely to trust humans who show them love, rather than those who give them food. These studies have important implications for understanding the evolution of the dog-human relationship. Thus, Anindita is now well on her way to making the Indian stray dog an excellent model system for animal behaviour, ecology, evolution and conservation.

Proposer: Prof. H.A. Ranganath , Seconder: Prof. R. Gadagkar


1. Anindita Bhadra, Priya L. Iyer, A. Sumana, Sujata A. Deshpande, Saubhik Ghosh and Raghavendra Gadagkar (2007). How do workers of the primitively eusocial wasp Ropalidia marginata detect the presence of their queens? Journal of Theoretical Biology 246, 574-582. doi:10.1016/j.jtbi.2007.01.007 (if=2.049, ci=24)

2. Anindita Bhadra and Raghavendra Gadagkar (2008). “We know that the wasps know”: Cryptic successors to the queen in the primitively eusocial wasp Ropalidia marginata. Biology Letters 4, 634-637. doi: 10.1098/rsbl.2008.0455 (if=3.345, ci=16)

3. Anindita Bhadra, Aniruddha Mitra, Sujata Deshpande, K. Chandrashekhar, Dattatraya G. Naik, Abraham Hefetz and Raghavendra Gadagkar (2010). Regulation of reproduction in the primitively eusocial wasp Ropalidia marginata: On the trail of the Queen pheromone. J. Chemical Ecology 36 (4), 424-431. DOI 10.1007/s10886-010-9770-x. (if=3.151, ci=36)

4. Sreejani Sen Majumder, Anandarup Bhadra, Arjun Ghosh, Soumitra Mitra, Debottam Bhattacharjee, Jit Chatterjee, Anjan K. Nandi and Anindita Bhadra (2014). To be or not to be social: Foraging associations of free-ranging dogs in an urban ecosystem. Acta Ethologica 17 (1): 1-8. doi: 10.1007/s10211-013-0158-0 (if=0.804, ci=35)

5. Manabi Paul, Sreejani Sen Majumder and Anindita Bhadra (2013). Selfish mothers? An empirical test of parent-offspring conflict over extended parental care. Behavioural Processes. 103: 17-22. doi: 10.1016/j.beproc.2013.10.006 (if=1.555 , ci=18)

6. Sreejani Sen Majumder and Anindita Bhadra (2015). When love is in the air: Understanding why dogs tend to mate when it rains. PLoS ONE 10(12): e0143501. doi:10.1371/journal.pone.0143501 (if=2.766 , ci=10)

7. Manabi Paul, Sreejani Sen Majumder, Anjan K. Nandi and Anindita Bhadra (2015). Selfish mothers indeed! Resource-dependent conflict over extended parental care in free-ranging dogs. Royal Society Open Science 2: 150580; DOI: 10.1098/rsos.150580 (if=2.504 , ci=10)

8. Manabi Paul, Sreejani Sen Majumder, Subhra Sau, Anjan K. Nandi and Anindita Bhadra (2016). High early life mortality in free-ranging dogs is largely influenced by humans. Scientific Reports 6:19641; DOI: 10.1038/srep19641 (if=4.122, ci=18)

9. Debottam Bhattacharjee, Shubhra Sau, Jayjit Das and Anindita Bhadra (2017). Free-ranging dogs prefer petting over food in repeated interactions with unfamiliar humans. Journal of Experimental Biology 220: 4654-4660. doi: 10.1242/jeb.166371 (if=3.32, ci=5)

10. Manabi Paul and Anindita Bhadra (2018). The great Indian joint families of free-ranging dogs. PLoS ONE 13(5): e0197328. https://doi.org/10.1371/journal.pone.0197328. (if=2.766, ci=0)

299

BHATTA, RAGHAVENDRA (b 1965), Director, ICAR-National Institute of Animal Nutrition and Physiology, Bengaluru


Dr. Bhatta’s significant contribution is the development of All India district-wise inventory on enteric methane emission. This is the first of its kind because it is based on a) the primary data on enteric methane emission factor b) feeding management at different agro-eco zones and c) latest livestock census. He has developed simple, cost effective and eco-friendly strategies and products for enteric methane amelioration. Two such products are ‘Harit Dhara’ and ‘Tamarin Plus’. Harit Dhara is prepared from selected phyto-sources and daily oral administration of Harit Dhara to adult cattle and buffaloes, reduces methane emission upto 700 litres CO2 eq/day, with a BCR ratio of 3:1. Tamarin Plus (Patented) is a complete-feed-block for enteric methane amelioration (15-20 %). He has also developed ‘ReproFat Plus’, product for addressing low fertility and low milk fat in dairy animals. Another product is a specific mineral mixture for breeding bulls and both these products are under commercialization. Recently, Dr Bhatta has commercialized small ruminant mineral mixture (Patented)to M/s. Kamdhenu Feeds, Saharanpur and M/s. Shakthi Feeds, Meerut, Uttar Pradesh. He has filed 3 patent applications. He has published more than 100 research papers in journals (>1600 citations) of international repute; has authored 3 books, one each in Cambridge University Press, London and Springer. He is recipient of several awards including Prestigious Sir CV Raman State Award from Karnataka State Council for Science and Technology, Govt. of Karnataka. He is the Fellow of National Academy of Veterinary Science and National Academy of Diary Sciences.

Proposer: Dr. S. Ayyappan, Seconder: Dr. P.K. Ghosh


1. Bhatta R*, Saravanan M, Baruah L, and Prasad CS. (2015) Effects of graded levels of tannin-containing tropical tree leaves on in vitro rumen fermentation, total protozoa and methane production, Journal of Applied Microbiology, 118, 557-564 (if=J069 8.16, ci= 35)

2. Bhatta R*, Baruah L, Saravanan M, Suresh KP and Sampath KT. (2013). Effect of tannins from medicinal and aromatic plants on rumen fermentation, protozoa population and methanogenesis in vitro. Journal of Animal Physiology and Animal Nutrition. 97(3) 446-456(if=J047 7.61, ci= 39)

3. Bhatta R*, O. Enishi, Y. Yabumoto, I. Nonaka, N. Takusari, K. Higuchi, K. Tajima, A. Takenaka and M. Kurihara (2013) Methane reduction and energy partitioning in goats fed two concentrations of tannin from Mimosa spp. Journal of Agricultural Science (Cambridge). 151: 119-128 (if=J024 7.19, ci= 31)

4. Bhatta R*, M. Saravanan, L. Baruah and K. T. Sampath (2012). Nutrient content, in vitro ruminal fermentation characteristics and methane reduction potential of tropical tannin-containing leaves. Journal of the Science of Food and Agriculture. 92:2929-2935 (if=J495 8.38, ci= 42)

5. Bhatta R*, Y. Uyeno, K. Tajima, A. Takenaka, Y. Yabumoto, I. Nonaka, O. Enishi and M. Kurihara (2009). Difference in the nature of tannins on in vitro ruminal methane and volatile fatty acid production, and methanoginic archaea and protozoal populations. Journal Dairy Science, 92 (11): 5512-5522 (if=J168 8.75, ci= 198)

6. Bhatta R*, O. Enishi, N. Takusari, K. Higuchi, I. Nonaka and M. Kurihara (2008). Diet effects on methane production by goats and a comparison between measurement methodologies. Journal of Agricultural Science (Cambridge) 146: 705-715 (if=J024 7.19, ci= 46)

7. Bhatta R*, S. Vaithiyanathan, N. P. Singh and D. L. Verma (2007) Effect of feeding complete diets containing graded levels of Prosopis cineraria leaves on feed intake, nutrient utilization and rumen fermentation in lambs and kids. Small Ruminant Research, 67(1) 75-83(if=S046 6.97, ci= 33)

8. Bhatta R*, A. K. Shinde, S. Vaithiyanathan, S. K. Sankhyan and D. L. Verma. (2002) Effect of Polyethylene glycol-6000 on nutrient intake, digestion and growth of kids browsing Prosopis cineraria. Animal Feed Science and Technology, 101 (1-4): 45-54 (if=A167 8.14, ci= 80)

9. Bhatta R*, U. Krishnamoorthy and F. Mohammed (2001) Effect of tamarind (Tamarindus indica) seed husk tannins on in vitro rumen fermentation. Animal Feed Science and Technology, 90(3-4) 143-152 (if=A167 8.14, ci= 58)

10. Bhatta R*, U. Krishnamoorthy and F. Mohammed (2000) Effect of feeding tamarind (Tamarindus indica) seed husk as a source of tannin on dry matter intake, digestibility of nutrients and production performance of crossbred dairy cows in mid lactation. Animal Feed Science and Technology, 83: 67-74 (if=A167 8.14, ci= 69)

300

DEB, RAJIB (b 1981), Scientist (SS), ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh, India


Dr. Rajib Deb, Ph.D, TWAS Post-Doctoral Fellow, NAAS (Associate), Scientist (Senior Scale), ICAR-Central Institute for Research on Cattle, Meerut, UP, India has made outstanding contributions in advanced molecular biology and genetics research of livestock specially cattle, the prime animals in agriculture. His research reflects a continuum of high quality basic, strategic, and applied research in cattle health and productivity. He has contributed in the evaluation of “Frieswal”, one of the crossbred strains in India. His major research contribution towards agriculture sectors are highlighted here-(i) Developed a LAMP assay for early detection of cow milk/meat adulterated in buffalo or goat counterparts, which is economical and user friendly(ii) Methodologies developed for user friendly tests for early detection of certain genetic disorders in breeding bulls prior to collection of germplasms (iii) ANN methodology developed for early prediction of bull semen post thaw motility which may reduce time and manpower(iv) Discovered the docking site of FMD virus on it’s bovine host receptor for the first time (v) Catalogued novel microRNAs which are directly or indirectly related to cellular thermotolerance in cattle (vi) For the first time demonstrated the use of GBS for a rapid inventory of the more than 100,000 SNPs in seven major Indian zebu cattle breeds which might prompt implementation of GBS in breeding policy of cattle (vii)For the first time identified Factor XI deficiency in Indigenous cattle breed, which can be implemented for genetic disease screening policy in Indian breeding bulls. He has filed 5 Indian Patents.

Proposer: Prof. S. Ayyappan, Seconder: Prof. Aparna Dutta Gupta


1. Singh, I., Deb, R et al., (2019). Deciphering Foot-and-Mouth Disease (FMD) virus-host Tropism. Journal of Biomolecular Structure and Dynamics, 18:1-13. (if=3.17, ci=...)

2. Deb R et al., (2014) Effect of heat stress on the expression profile of Hsp90 among Sahiwal (Bos indicus) and Frieswal (Bos indicus X Bos taurus) breed of cattle: A comparative study. Gene. 25; 536 (2):435-40. (if=2.49, ci=50)

3. Deb R et al., (2013) Promoter variants at AP2 box region of Hsp70.1 affect thermal stress response and milk production traits in Frieswal cross bred cattle. Gene. 15; 532(2):230-5. (if=2.49, ci=31)

4. Gupta SK, Bajwa P, Deb R, Chellappa MM, Dey S. (2014) Flagellin-A TLR5 agonist as an adjuvant in chicken vaccines. Clinical and Vaccine Immunology. 21(3):261. (if=2.872, ci=32)

5. Gupta SK, Deb R, Chellappa M M, Dey S. (2014) TLR based adjuvants – Enhancing the immune response to vaccines against infectious diseases of chicken. Expert Review of Vaccines. 13(7):909-925 (if=4.22, ci=25)

6. Sengar G S, Deb R et al., (2018) Identification of differentially expressed microRNAs in Sahiwal (Bos indicus) breed of cattle during thermal stress. Cell Stress and Chaperones. 23(5):1019-1032. (if=2.5, ci=3)

7. Sengar G S, Deb R et al., (2017) Differential expression of microRNAs associated with thermal stress in Frieswal (Bos taurus x Bos indicus) crossbred dairy cattle. Cell Stress and Chaperones.23(1): 155–170. (if=2.5, ci=6)

8. Sajjanar B, Deb R et al., (2017) Untranslated regions (UTRs) orchestrate translation reprogramming in cellular stress response. Journal of Thermal Biology. 65:69-75 (if=2.157, ci=9)

9. Deb R et al., (2015) Understanding the mechanisms of ATPase beta family genes for cellular thermo tolerance in crossbred bulls, International Journal of Biometrology,59: 1783-1789. (if=2.577, ci=6)

10. Deb R et al., (2015) Designing of an Artificial Neural Network model to evaluate the association of three combined Y specific microsatellite loci on the actual and predicted post thaw motility in crossbred bull semen, Theriogenology, 83 (9): 1445–145 (if=2.136, ci=3)

301

GARG, LALIT CHANDER (b 1952), INSA Senior Scientist, National Institute of Immunology, New Delhi


Dr.Garg’s group has been engaged in understanding the molecular mechanisms underlying pathobiolgy of infectious organism for the development of vaccines and to identify new drug targets.He has made seminal contribution towards the development of a vaccine against epsilon-toxin of Clostridium perfringens D, a major cause of veterinary enteric disease (Appl.Microbiol.Biotechnol. 2010, Clin. VaccineImmunol.2010). This basic research work has been translated into a technology transfer to an industry for which phaseII trials have been completed. Based on structure-function relation, his group identified critical amino acid residues responsible for the toxicity of the epsilon-toxin and developed non-toxic recombinant vaccines against the toxin, for which international patents have been granted(PatentApplication#1577/DEL/2010,05-07-2010). Further, using deletion variants of LTB, he has demonstrated the critical role of the N-terminal α1 helix of heat-labile enterotoxin B subunit (LTB) of enterotoxigenic Escherchia coli in its stability (PNAS,2007). His studies on PE_PGRS proteins of Mycobacterium tuberculosis gave deep insight into their roles in its virulence and latency (FEMS Microbiol.Letters2011; FEBS Letters2014; MicrobesandInfection2016). Dr. Garg’s t contribution in the area of recombinant proteins of therapeutic importance are noteworthy. He is the first one to deposit gene sequences to the data base from buffalo.His research on recombinant expression of buffalo and human growth hormones in large amounts using bacterial expression systems has led to the technology transfer for their industrial production to an industry (Gene, 1995; PEP, 2000).

Proposer: Dr. Sher Ali, Seconder: Dr. Anil Suri


1. Solanki AK, Bhatia B, Kaushik H, Deshmukh SK, Dixit A, Garg, LC (2017) Clostridium perfringens beta toxin DNA prime-protein boost elicits enhanced protective immune response in mice. Appl. Microbiol. Biotechnol. 101, 5699-5708. (if=3.42, ci=7)

2. Chatrath S, Gupta VK, Dixit A and Garg LC (2016) PE_PGRS30 of Mycobacterium tuberculosis mediates suppression of proinflammatory immune response in macrophages through its PGRS and PE domains. Microbes Infect. 18:536-542. (if=2.152, ci=3)

3. Chatrath S, Gupta VK and Garg LC (2014) The PGRS domain is responsible for translocation of PE_PGRS30 to cell poles while the PE and the C-terminal domains localize it to the cell wall. FEBS Lett, 588: 990-994. (if=3.519, ci=7)

4. Mathur DD, Deshmukh S, Kaushik H, Garg LC (2010) Functional and structural characterization of soluble recombinant epsilon toxin of Clostridium perfringens D, causative agent of enterotoxaemia. Appl Microbiol Biotechnol, 88: 877-884. (if=3.42, ci=29)

5. Chandran D, Naidu SS, Sugumar P, Rani GS, Vijayan SP, Mathur D, Garg LC, Srinivasan VA (2010) Development of a recombinant epsilon toxoid vaccine against enterotoxemia and its use as a combination vaccine with live attenuated sheep pox virus again (if=2.598, ci=35)

6. Alone P, Malik G, Krishnan A, Garg LC (2007). Deletion mutations in N-terminal alpha1helix render heat labile enterotoxin B subunit susceptible to degradation. Proc Natl Acad Sci U S A, 104: 16056-16061. (if=9,661, ci=9)

7. Patra AK, Mukhopadhyay R, Mukhija R, Krishna A, Garg LC, Panda AK (2000) Optimization of inclusion body solubilization and renaturation of recombinant human growth hormone from Escherichia coli. Prot Expr Purif., 18: 182-192. (if=1.695, ci=234)

8. Goswami P, Rupa P, Prihar NS, Garg LC (1996) Molecular cloning of Clostridium perfringens epsilon-toxin gene and its high level expression in E. coli. Biochem. Biophys. Res Commun., 226: 735-40. (if=2.297, ci=30)

9. Mukhija R, Rupa P, Pillai D, Garg LC (1995) High level expression and one step purification of biologically active human growth hormone in E. coli. Gene, 165: 303-306. (if=2.319, ci=64)

10. Ghorpade A, Garg LC (1993) Efficient processing and export of human growth hormone by heat labile enterotoxin chain B signal sequence. FEBS Letters, 330: 61-65. (if=3.519, ci=22)

302

HEGDE, NAGENDRA RAMACHANDRA (b 1967), Scientist G, National Institute of Animal Biotechnology, Hyderabad


Dr. Hegde is a biologist working in the field of infectious disease with an illustrious career in epidemiology, genomics, host-pathogen interactions, vaccines and diagnostics. His early research focused on hemagglutination of peste des petits ruminants virus; he was one of the first to characterize this activity of the virus. He then worked on the fundamental biology of peptide binding characteristics of the bovine major histocompatibility complex (MHC) class I molecules; he reported the first allele-specific peptide binding motif of any bovine MHC molecule. Later, he studied the cell biology of immune evasion by human cytomegalovirus, leading to the key contribution on the first two viral inhibitors of the MHC class II pathway of antigen presentation. He also worked on the development and testing in animal models of adenovirus-vectored vaccine to hantaviral disease. Following the establishment of his own independent group, he (a) worked extensively on the epidemiology of bluetongue virus in India, contributing to the understanding of the emergence and movement of the virus strains, and development of molecular diagnostics, (b) ventured into epidemiology and prophylactic measures for bovine mastitis caused by staphylococci, and (c) has been involved in the development and/or testing of several vaccines of importance to humans. In summary, Dr. Hegde has contributed both to the basic understanding of pathogen emergence and biology as well as ways to diagnose and prevent infectious diseases of humans and livestock. He has also contributed to training and teaching several students to enhance human resource generation.

Proposer: Dr. Subeer S. Majumdar, Seconder: Dr. J. Gowrishankar


1. PP Rao, NR Hegde, YN Reddy, YK Jyothi, YV Reddy, B Susmitha, K Putty, GH Reddy. 2016. Epidemiology of bluetongue in India. Transbound Emerg Dis 63(2):e151-64. (if=3.585, ci=20)

2. A Singh, M Mitra, …, NR Hegde*, MM Gore, VK Mohan, KM Ella. 2015. A Japanese encephalitis vaccine from India induces durable and cross-protective immunity against temporally and spatially wide-ranging global field strains. J Infect Dis 212(5):715-25. (if=6.273, ci=17)

3. PL Preethirani, S Isloor, …., NR Hegde*. 2015. Isolation, biochemical and molecular identification, and in-vitro antimicrobial resistance patterns of bacteria isolated from bubaline subclinical mastitis in South India. PLoS ONE 10(11):e0142717. (if=2.806, ci=10)

4. S Manjunath, PG Kulkanri, K Nagavelu, RJ Samuel, N Ramasamy, NR Hegde*, RS Gudde*. 2015. Sero-prevalence of rodent pathogens in India. PLoS ONE 10(7):e0131706. (if=2.806, ci=8)

5. D Safronetz, NR Hegde, H Ebihara, M Denton, GP Kobinger, S St Jeor, et al. 2009. Adenovirus vectors expressing hantavirus proteins produce sterile immunity and protect hamsters against lethal challenge with Andes virus. J Virol 83(14):7285-95. (if=4.663, ci=42)

6. NR Hegde, MS Chevalier, TW Wisner, MC Denton, K Shire, L Frappier, et al. 2006. The role of BiP in ER-associated degradation of major histocompatibility complex class I heavy chain induced by cytomegalovirus proteins. J Biol Chem 281:20910-19. (if=4.125, ci=55)

7. NR Hegde, C Dunn, DM Lewinshohn, MA Jarvis, JA Nelson, DC Johnson. 2005. Endogenous human cytomegalovirus gB is efficiently presented by MHC class II molecules to CD4+ CTL. J Exp Med 202(8):1109-19. (if=11.991, ci=83)

8. NR Hegde, RA Tomazin, TW Wisner, C Dunn, et al. 2002. Inhibition of assembly, transport and loading of HLA-DR by human cytomegalovirus glycoprotein US3: a novel mechanism for evading MHC class II antigen presentation. J Virol 76(21):10929-41. (if=4.663, ci=125)

9. R Tomazin, J Boname, NR Hegde, DM Lewinsohn, Y Altschuler, TR Jones, P Cresswell, JA Nelson, et al. 1999. Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells. Nature Med 5(9):1039-43. (if=29.886, ci=278)

10. NR Hegde, SA Ellis, RM Gaddum, CA Tregaskes, G Sarath, S Srikumaran. 1995. Peptide motif of cattle MHC class I antigen, BoLA-A11. Immunogenetics 42(4):302-03. (if=2.092, ci=27)

303

JOSHI, PRAKASH CHANDRA (b 1964), Professor, Gurukula Kangri Vishwavidyalaya, Haridwar


Prof. Joshi has been working in the field of insect ecology and air pollution since last 26 years. He has extensively worked on insect fauna of Himalayan region including Nanda Devi Biosphere Reserve, Pindari, Askot, Mukteshwar and Rajaji National Parks, determining the role of insect fauna in sustaining forests, status of insect pollinators as impacted by anthropogenic activities and decline in oak tasar worm in the Garhwal Himalaya. He has published 121 research papers and 06 books, completed 10 major research projects sanctioned by different funding agencies. He has been awarded fellowship by British High Commission and the BOYSCAST fellowship by DST, GOI to visit many universities abroad. Visited 14 foreign Universities in USA, UK, China, Singapore, Malasiya and Thiland not only to have collaborative research work but to deliver invited talks. He has been a recipient of Gold medal of ZSI, Platinum Jubilee lecture award of ISCA in 2015. Elected President, Animal, Veterinary and Fisheries Science Section of ISCA-107 in 2019. Supervised 23 Ph. D. and 32 M. Sc. Dissertations. Presently 05 students are registered for their Ph. D. After the establishment of State Industrial Development Corporation in Uttarakhand, he started collecting data on air pollution and its impacts in and around the city of Haridwar. The findings have been published in reputed journals and are being highly cited world over. He has continuously been writing in daily news papers on issues like loss of biodiversity, pollination, pollution to create awareness among masses

Proposer: Dr. Rajendra Dobhal, Seconder: Prof. Omkar


1. P. C. Joshi, A. Swami (2007). Physiological responses of some tree species under roadside automobile pollution stress around city of Haridwar, India. The Environmentalist 27 (3), 365-374 (ci=143)

2. P.C. Joshi, A. Swami (2009). Air pollution induced changes in the photosynthetic pigments of selected plant species. Journal of Environmental Biology 30 (2), 295-298 (ci=104)

3. N. Joshi, A. Chauhan, P. C. Joshi (2009). Impact of industrial air pollutants on some biochemical parameters and yield in wheat and mustard plants. The Environmentalist 29 (4), 398-404 (ci=67)

4. A Swami, D Bhatt, PC Joshi (2004). Effects of automobile pollution on sal (Shorea robusta) and rohini (Mallotus phillipinensis) at Asarori, Dehradun. Himal J Environ Zool 18 (1), 57-61 (ci=58)

5. A. Chauhan, P. C. Joshi (2010). Effect of ambient air pollutants on wheat and mustard crops growing in the vicinity of urban and industrial areas. New York Sci. J 3 (2), 52-60 (ci=56)

6. NC Joshi, PC Joshi (2010). Foraging behaviour of Apis spp. on apple flowers in a subtropical environment. New York Science Journal 3 (3), 71-76 (ci=56)

7. PC Joshi, A Chauhan (2008). Performance of locally grown rice plants (Oryza sativa L.) exposed to air pollutants in a rapidly growing industrial area of district Haridwar, Uttarakhand, India. Life Science Journal 5 (3), 41-45 (ci=43)

8. G Sharma, PC Joshi (2009). Diversity of Butterflies (Lepidoptera: Insecta) from Dholbaha dam (Distt. Hoshiarpur) in Punjab Shivalik, India. Biological Forum 1 (2), 11-14 (ci=34)

9. PC Joshi, JA Lockwood, N Vashishth, A Singh (1999). Grasshopper (Orthoptera: Acridoidea) community dynamics in a moist deciduous forest in India. Journal of Orthoptera Research, 17-23 (ci=27)

10. A. Chauhan, P. C. Joshi (2010).Composting of some dangerous and toxic weeds using Eisenia foetida. J. Am. Sci 6 (3), 1-6 (ci=25)

304

MADAN, TARUNA (b 1968), Scientist F, and Head, Department of Innate Immunity, ICMR- National Institute for Research in Reproductive Health, Mumbai, Parel, 400012


Dr. Taruna Madan has pioneered the research on collectins, a family of immunoregulatory pattern recognition proteins. She has deciphered their relevance in host defense, cancer surveillance and reproductive health. With a series of elegant studies in murine models and knock-out mice she established the therapeutic potential of collectins viz. SP-A, SP-D and MBL against the fungal pathogen Aspergillus fumigatus (Madan et al.,1997a;1997b;2001a;2001b;2002; 2005a;2005b;2010; Kaur et al.,2007;2006;2005). Importantly, her team made an outstanding discovery that SP-D recognizes the immune-evasive dormant conidia via melanin through its collagen-like domain (Sze Wah Wong et al.,2018). She has developed synthetic epitope based diagnostic kits to detect A. fumigatus specific IgG and IgE antibodies (Madan et al.,2004;US-patent6902901). Her group was the first to report the direct anti-cancer role of SP-D in leukemic and breast cancer cells via p53 and HMGA1 that was subsequently validated by other groups in pancreatic and ovarian tumor cells (Mahajan et al.,2013;2008). With an aim to develop a vaginal microbicide for HIV, she established the potent and broad spectrum anti-HIV activity of SP-D and elucidated SP-D mediated reversal of HIV-induced pro-inflammatory gene signature (Pandit et al., 2014;2016;2019; ICMR-patent1685/DEL/2009). Taking cues from the significance of immunoregulation in pregnancy and male fertility, she demonstrated critical roles of collectins in the murine embryo implantation, spermatogenesis and placental development (Yadav et al.,2014;2016; Kay et al.,2015,2016; Rokade et al.2016;2017). Clinical research by her group in HIV serodiscordants, preeclamptic women and infertile men has endorsed the translation potential of SP-D.

Proposer: Dr. Smita D. Mahale, Seconder: Dr. Krishna Balaji Sainis


1. Madan T, Eggleton P, Kishore U, Strong P, Aggrawal SS, Sarma PU, Reid KB. 1997. Binding of pulmonary surfactant proteins A and D to Aspergillus fumigatus conidia enhances phagocytosis and killing by human neutrophils and alveolar macrophages. Infect Immun. 65(8):3171-9. (if=3.256, ci=304)

2. Madan T, Kishore U, Shah A, Eggleton P, Strong P, Wang JY, Aggrawal SS, Sarma PU, Reid KB. 1997. Lung surfactant proteins A and D can inhibit specific IgE binding to the allergens of Aspergillus fumigatus and block allergen-induced histamine release from human basophils. Clin Exp Immunol. 110(2):241-9. (if=3.409, ci=178)

3. Madan T, Kishore U, Singh M, Strong P, Clark H, Hussain EM, Reid KB, Sarma PU. 2001. Surfactant proteins A and D protect mice against pulmonary hypersensitivity induced by Aspergillus fumigatus antigens and allergens. J Clin Invest. 107(4):467-75. (if=12.784, ci=217)

4. Madan T, Kishore U, Singh M, Strong P, Hussain EM, Reid KB, Sarma PU. 2001. Protective role of lung surfactant protein D in a murine model of invasive pulmonary aspergillosis. Infect Immun. 69(4):2728-31 (if=3.256, ci=122)

5. Saxena S, Madan T#, Shah A, Muralidhar K, Sarma PU. 2003. Association of polymorphisms in the collagen region of SP-A2 with increased levels of total IgE antibodies and eosinophilia in patients with allergic bronchopulmonary aspergillosis. J Allergy Clin Immunol. 111(5):1001-7. (if=12.485, ci=121)

6. Madan T, Reid KB, Singh M, Sarma PU, Kishore U. 2005. Susceptibility of mice genetically deficient in the surfactant protein (SP)-A or SP-D gene to pulmonary hypersensitivity induced by antigens and allergens of Aspergillus fumigatus. J Immunol. 174(11):6943-54.(if=4.92, ci=108)

7. Kaur S, Gupta VK, Shah A, Thiel S, Sarma PU, Madan T*. 2005. Plasma mannan-binding lectin levels and activity are increased in allergic patients. J Allergy Clin Immunol. 116(6):1381-3 (if=12.485, ci=68)

8. Kaur S, Gupta VK, Thiel S, Sarma PU, Madan T*. 2007. Protective role of mannan-binding lectin in a murine model of invasive pulmonary aspergillosis. Clin Exp Immunol. 148(2):382-9 (if=3.409, ci=90)

9. Mahajan L, Madan T*, Kamal N, Singh VK, Sim RB, Telang SD, Ramchand CN, Waters P, Kishore U, Sarma PU. 2008. Recombinant surfactant protein-D selectively increases apoptosis in eosinophils of allergic asthmatics and enhances uptake of apoptotic eosinophils by macrophages. Int Immunol. 20(8):993-1007 (if=5.189, ci=39)

10. Madan T*. 2017. Recombinant Fragment of Human Surfactant Protein D: A Hierarchical Regulator of Pulmonary Hypersensitivity. Am J Respir Crit Care Med. 15;196(12):1495-1496 (if=13.204, ci=2)

305

MAZUMDER, SHIBNATH (b 1964), Professor, University of Delhi, Delhi


Prof. Shibnath Mazumder’s long-time research interest has been emergent to develop intervention strategies against important zoonotic pathogens. He successfully used fish-model to understand Aeromonas hydrophila and Mycobacterium fortuitum induced pathogenesis. His group unveiled the novel paradigm where plasmid plays pivotal role in A.hydrophila-pathogenesis (Aquaculture, 2007, Microb Pathog, 2009), and developed translational disease intervention strategy using candidate vaccines against the bacterium (Fish Shellfish Immunol, 2006). Prof. Mazumder’s laboratory was first to report the occurrence of a quinolone-resistance plasmid in A. hydrophila which forced rethinking in controlling the bacterium (PLASMID, 2011). His group uncovered, the role of calcium and its dependent kinases in apoptosis induced by Aeromonas hydrophila and Mycobacterium fortuitum (Plos Pathogens, 2014; PLOS One, 2016; Dev Comp Immunol, 2017). His laboratory also revealed the role of ER-mitochondrial crosstalk in bacterial-pathogenesis in fish (Scientific Reports, 2014; Cell Death Discov, 2018). Recently, they demonstrated how TLR4 topology is exploited for immune-evasion and bacterial persistence, adding new aspect in understanding host-pathogen interactions (Cell Death Discov, 2017). Xenobiotic-immunotoxicity is not well understood yet. Prof. Mazumder’s group delineated the pathways triggering arsenic-induced apoptosis and identified the signature genes involved in the process (Toxicol Appl Pharmacol, 2009; J Hazard Mater, 2017). Recently, his group elucidated that chronic endosulfan-exposure cause immune commotion wherein the immune-organs per se, generate endosulfan-metabolites, principal components of endosulfan-toxicity (Aquat Toxicol, 2017). The research accomplishment of Prof. Mazumder is fundamental and ground breaking in nature. His recent series of publications in high visibility journals uncover novel mechanisms of bacterial-pathogenesis and immunity.

Proposer: Prof. Kasturi Datta, Seconder: Prof. Chinmay Kumar Mukhopadhyay


1. Majumdar. T, Sharma.S, Kumar. M, Hussain. Arafat, Chauhan. N, Kalia. I, Sahu, A.K, Rana. V.S, Bharti. R, Haldar. A.K, Singh. A.P, Mazumder. S. (2019). Tryptophan-kynurenine pathway attenuates β-catenin-dependent pro-parasitic role of STING-TICAM2-IRF3-IDO1 signalosome in Toxoplasma gondii infection. Cell Death Dis (Springer-Nature) DOI:10.1038/ (if=6.18, ci=0)

2. Datta. D, Khatri. P, Singh. A, Saha. D.R. Verma. G, Raman. R, Mazumder. S (2018). Mycobacterium fortuitum-induced ER-Mitochondrial calcium dynamics promotes calpain/caspase-12/caspase-9 mediated apoptosis in fish macrophages. Cell Death Discov. (Springer-Nature) DOI: 10.1038/s41420-018-0034-9 (if=Awaited, ci=03)

3. Srivastava. N, Shelly. A, Kumar. M, Pant. A, Das. B, Majumdar.T, Mazumder. S (2017). Aeromonas hydrophila utilizes TLR4 topology for synchronous activation of MyD88 and TRIF to orchestrate anti-inflammatory responses in zebrafish. Cell Death Discov. (Springer-Nature) 3. 17067. DOI: 10.1038/cddiscovery.2017.09.006 (if=Awaited, ci=04)

4. Ray. A, Bhaduri. A, Srivastava. N, Mazumder. S (2017). Identification of novel signature genes attesting arsenic-induced immune alterations in adult zebrafish (Danio rerio). J HAZARD MATER. DOI: 10.1016/j.jhazmat.2016.09.001 (if=6.06, ci=07)

5. Kumari. U, Srivastava. N, Shelly. A, Khatri. P, Sarat. N, Singh. D.K. and Mazumder. S (2016). Inducible headkidney cytochrome P450 contributes to endosulfan immunotoxicity in walking catfish Clarias gariepinus. Aquat Toxicol. 179. 44–54. DOI: 10.1016/j.aquatox.2016.08.009 (if=4.12, ci=08)

6. Datta. D, Khatri. P, Banerjee. C, Singh. A, Meena. R, Saha. D.R., Rajagopal, R, Rajamani. P, Mitra. A , Mazumder. S (2016). Calcium and superoxide-mediated pathways converge to induce nitric oxide-dependent apoptosis in Mycobacterium fortuitum-infected fish macrophages. PLoS ONE 11 (1): e0146554. doi:10.1371/journal.pone.0146554 (if=2.80, ci=09)

7. Banerjee.. C, Singh. A, Das. T.K, Rajagopal. R, Srivastava. A, Mazumder. S (2014). Ameliorating ER-stress attenuates Aeromonas hydrophila-induced mitochondrial dysfunctioning and caspase mediated HKM apoptosis in Clarias batrachus. Scientific Reports. DOI: 10.1038/srep05820 (if=4.25, ci=10)

8. Banerjee. C, Khatri. P, Rajagopal. R, Bhatia. H, Datta. M and Mazumder. S (2014). Role of Calmodulin-Calmodulin Kinase II, cAMP/Protein Kinase A and ERK 1/2 on Aeromonas hydrophila-Induced Apoptosis of Head Kidney Macrophages. PLOSPathogens. 10.1371/journal.ppat.1004018 (if=6.608, ci=21)

9. Datta, S, Ghosh, D, Saha, D.R, Bhattacharaya, S, Mazumder, S (2009). Chronic exposure to low concentration of arsenic is immunotoxic to fish: Role of head kidney macrophages as biomarkers of arsenic toxicity to Clarias batrachus. Aquat Toxicol. 92. 86–94(if=4.12, ci=90)

10. Ghosh, D., Datta Soma, Bhattacharya & Mazumder, S (2007). Long term exposure to arsenic affects head kidney and impairs humoral immune responses of Clarias batrachus. Aquat Toxicol. 81, 79-89 (if=4.12, ci=68)

306

MONDAL, SUKANTA (b 1970), Principal Scientist, ICAR-National Institute of Animal Nutrition and Physiology, Bangalore


Dr. Mondal made outstanding contributions in reproductive genomics which was exemplified by his excellent publications in frontier journals. He cloned and characterized COX-2, PGES, PGFS, osteopontin, galactin, and integrin genes in sheep and delineated the molecular mechanisms involved in maternal recognition of pregnancy. He also cloned and characterized PGES, PGFS and FSH receptor genes in buffalo (Mondal et al., 2008) for the first time in the world. He deciphered molecular basis of climate change impact on embryonic survivality in sheep (Mondal et al., 2014; Mondal et al., 2015). His group identified MRP4 as a functional prostaglandin carrier in bovine endometrium (Nicholas et al., 2011). He is pioneer in studying expression profiling of developmentally important genes to unravel the intricacies of implantation and early embryo development in sheep (Mishra et al., 2016; Mor et al., 2018). He established that elevated level of metabolic stressors induced granulosa cell apoptosis through BAX/BCL-2 pathway and reduced stereoidogenic gene expression (Nandi et al., 2015; 2016; 2017). He made notable contribution in understanding the effect of silencing of prolactin (PRL) gene on PRL, PRL mRNA and PRL, PRLR and GH protein expression in poultry (Reddy et al., 2014). He also identified boron as a trace element and its role in immunity and antioxidant responses in rat (Vijay Bhaskar et al., 2016; 2017). He was instrumental in developing technology for augmenting egg production in layer birds by exposing red spectrum of light (675 nm). I strongly recommend him for the award of NASI Fellowship.

Proposer: Dr. Saumen Kumar Maitra, Seconder: Dr. Biswaranjan Maiti


1. Mondal, S., Minj, A., Tiwari, A.K, Sharma, B. and Varshney, V.P. (2008) Molecular characterization of FSH receptor (FSHR) gene in Indian river buffalo. General and Comparative Endocrinology 158:147-153. (if=2.823, ci=12)

2. Palta, P., Mondal, S., Prakash, B.S and Madan, M.L. (1997) Peripheral inhibin levels in relation to climatic variations and stage of estrous cycle in buffaloes (Bubalus bubalis). Theriogenology 47(5): 989-995. (if=2.136, ci=36)

3. Nicolas LP, Danyod G, Swamy NK, Mondal S, Rong PM, Chapdelaine P, Fortier MA(2011)The Multidrug Resistance-Associated Protein 4 appears as a Functional Carrier of Prostaglandins Regulated by Oxytocin in Bovine Endometrium. Endocrinology 152:4993-5004. (if=3.961, ci=22 )

4. Suresh, K.P., Nandi, S. and Mondal, S. (2009) Factors affecting laboratory production of buffalo embryos: A meta-analysis. Theriogenology 72:978-985. (if=2.136, ci=18 )

5. Vijay BT,Gowda NKS,Mondal S,Krishnamoorthy P,Pal DT,Mor A,Pattanaik AK(2016)Boron influences immune and antioxidant responses by modulating superoxide dismutase activity under calcium deficit abiotic stress in rats.J.Trace Elements Med.Biol.36:73-79(if=3.225, ci=15 )

6. Nandi, S., Mondal, S. and Reddy, I.J. (2012) Effect of prostaglandin producing modulators on in vitro growth characteristics in buffalo endometrial epithelial cells. Theriogenology 77:1014-1020. (if=2.136, ci=2 )

7. Mishra A, Reddy IJ, Gupta PSP, Mondal S(2016)L-carnitine mediated reduction in oxidative stress and alteration in transcript level of antioxidant enzymes in sheep embryos produced in vitro. Reproduction in Domestic Animal doi:10.1111/rda.12682 (if=1.422, ci=20 )

8. Vijay BT,Gowda NKS,Pal DT,KarthikBS,KrishnamoorthyP,Mondal S,Pattanaik AK,Verma AK(2017)Influence of boron supplementation on performance, immunity and antioxidant status of lambs fed diets with or without adequate level of calcium.PLoS ONE12:e0187203(if=2.766, ci=4 )

9. Nandi, S., Tripathi, S.K., Gupta, P.S.P. and Mondal, S. (2017) Nutritional and metabolic stressor on ovine oocyte development and granulosa cell functions in vitro. Cell Stress and Chaperone https://doi.org/10.1007/s12192-017-0846-1 (if=2.571, ci=1 )

10. Swain, P.S., Rao, S. B. N., Rajendran, D., Pal, D. T., Mondal, S. and Selvaraju, S. (2018) Effect of Supplementation of Nano Zinc Oxide on Nutrient Retention, Organ and Serum Minerals Profile, and Hepatic Metallothionein Gene Expression in Wister Albino Rats. Biological Trace Element Research doi.org/10.1007/s12011-018-1517-5 (if=2.361, ci=Yet to be cited)

307

SINGH, RAJ KUMAR (b 1958) Director & Vice Chancellor, ICAR-Indian Veterinary Research Institute (Deemed University), Izatnagar


Dr Raj Kumar Singh has >30 years of research & teaching experience in biotechnology, microbiology and virology. He has made significant contributions in the field of Animal Science by developing vaccines and diagnostics which are commercialized to business houses and state Biologicals. The diagnostics developed for important animal diseases are being used routinely for sero-surveillance in the country. He has developed innovative methods for diagnosis and prophylaxis and got two patents granted besides five national patents in pipeline. He has published >240 research articles and handled several research projects including contract research projects. He has made commendable efforts towards establishing linkages with various national and international organizations for promoting research and has been instrumental in various capacity building programmes and also guided Masters and doctoral students of Animal Biotechnology & Virology. He has established International collaboration with different research laboratories which led to creation of OIE referral laboratories for Equine diseases. He also laid foundation of VTCC which now has collection of > 2000 microbes and WGS completed for some pathogens. He has been awarded with many prestigious awards and fellowships including DBT TATA Innovation Fellowship, ICAR Rafi Ahmed Kidwai Award, Team Research Award, Agriculture Research Leadership Award and many others. He is a fellow of National and International Bodies and has served in apex administrative capacities including Director of NRC on Equines, VTCC, NRC on Buffaloes and NRC on Camels. He is presently holding the position of Director and Vice Chancellor of the Indian Veterinary Research Institute, Deemed University.

Proposer : Dr. Subeer S Majumdar, Seconder :Dr. Rishendra Verma Ten Best Publications: 1. Hosamani, M.; Singh, S.K.; Mondal, B.; Sen, A.; Bhanuprakash, V.; Yadav, M.P.; Bandyopadhyay, S.K. and Singh R.K. (2006). A bivalent vaccine against goat pox and peste des Petits ruminants induces protective immune response in goats. Vaccine 24: 6058-6064. (if= 3.235 ci= 55) 2. Virmani, N.; Bera, B.C.; Singh, B.K.; Shanmugasundaram, K.; Gulati, B.R.; Barua, S.; Vaid, R.; Gupta, A.K.; and Singh, R.K. (2010). Equine influenza outbreak in India (2008-2009): Virus isolation, seroepidemiology and phylogenetic analysis of HA gene. Vet. Microbiol. 143(2-4): 224-237. (if= 2.628 ci= 52) 3. Pallavi R, Roy N, Nageshan RK, Talukdar P, Pavithra SR, Reddy R, Venketesh S, Kumar R, Gupta AK, Singh RK, Yadav SC, Tatu U. (2010). Heat shock protein 90 as a drug target against protozoan infections: biochemical characterization of HSP90 from Plasmodium falciparum and Trypanosoma evansi and evaluation of its inhibitor as a candidate drug. J. Biol. Chem. 285(49): 37964-37975 (Epub Sep 13, 2010). (if= 4.125 ci= 120) 4. Roy N, Nageshan RK, Pallavi R, Chakravarthy H, Chandran S, Kumar R, Gupta AK, Singh RK, Yadav SC, Tatu U. (2010). Proteomics of Trypanosoma evansi infection in rodents. PLoSOne 5(3): 1-10 (e9796). (if= 2.806 ci= 22) 5. Bera, B.C.; Shanmugasundaram, K.; Barua, S.; Venkatesan, G.; Riyesh, T.; Bhanuprakash, V.; Gulati, B.R.; Vaid, R.K.; Virmani, N.; Kakker, N.K.; Malik, P.; Bansal, M.; Gadvi, S.; Singh, R.V.; Yadav, V.; Sardari Lal; Nagarajan, G.; Balamurugan, V.; Hosamani, M.; Pathak, K.M.L.; Singh, R.K. (2011). Zoonotic cases of camelpox infection in India. Vet. Microbiol. 152(1-2): 29-38 (doi: 10.1016/j.vetmic.2011.04.010). (if= 2.628 ci= 47) 6. Anand T, Bera BC, Vaid RK, Barua S, Riyesh T, Virmani N, Hussain M, Singh RK, Tripathi BN (2016). Abundance of antibiotic resistance genes in environmental bacteriophages. J. Gen. Virol. 97: 3458 – 3466 (doi:10.1099/jgv.0.000639). (if= 2.832 ci= 03) 7. Lalsiamtharaa, J.; Gogiaa, N.; Goswami, T. K.; Singh, R. K.; Chaudhuri, P. (2015). Intermediate rough Brucella abortus S19_per mutant is DIVA enable, safe to pregnant guinea pigs and confers protection to mice. Vaccine 33(22): 2577-2583 (doi: 10.1016/j.vaccine.2015.04.004). (if= 3.235 ci= 14) 8. Pavulraj, S.; Bera, B. C.; Joshi, Alok; Anand, T.; Virmani, Meenakshi; Vaid, R. K.; Shanmugasundaram, K.; Gulati, B. R.; Rajukumar, K.; Singh, R.; Misri, J.; Singh, R. K.; Tripathi, B. N.; Virmani, N. (2015). Pathology of equine influenza virus (H3N8) in murine model. PLoSOne 10(11): e0143094 (doi:10.1371/journal.pone.0143094). (if= 2.806 ci= 1) 9. Pandey Aruna, Sahu AR, Wani, SA, Saxena S, Kanchan S, Sah V, Rajak KK, Khanduri A, Sahoo AP, Tiwari AK, Mishra B, Muthuchelvon D, Mishra BP, Singh RK (2017). Modulation of Host miRNAs Transcriptome in Lung and Spleen of Peste des Petits Ruminants Virus Infected Sheep and Goats. Frontiers Microbiol. 8: 1146 (doi: 10.3389/fmicb.2017.01146). (if= 4.165 ci= 1) 10. Kumar, Sanjay; Kumar, Rajender; Gupta, a. K.; Yadav, S. C.; Goyal, S. K.; Khurana, S. K.; Singh, R. K. (2013) Development of EMA-2 recombinant antigen based enzyme-linked immunosorbent assay for seroprevalence studies of Theileria equi infection in Indian equine population. Vet. Parasitology 198: 10–17 (if= 2.278 ci= 11)

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308

YADAV, RAJPAL SINGH (b 1958), Scientist (P5 - diplomatic grade), Vector Ecology & Management, Department of Control of Neglected Tropical Diseases, World Health Organization Geneva 27, 1211, Switzerland.


Dr. Yadav is an expert in malariology and a global leader in vector biology and control policies, strategies and field operations. He contributed to developing the integrated disease vector control technology in India as part of a Technology Mission (1984–1987); established a field station of ICMR-National Institute of Malaria Research in Rourkela (1988–1995) and headed NIMR field station in Gujarat (1996–2008). He studies bionomics of vectors of malaria (An. culicifacies, An. stephensi, An. fluviatilis), dengue and Culex spp. the forested, urban, irrigated and semi-arid ecosystems; assessed impact of irrigation and climate on malaria in western India; monitored insecticide resistance; investigated malaria and dengue epidemics; field tested local approaches and supported in health emergencies. He was a 5-time consultant to WHO offices in New Delhi, Cairo and WHO HQ (1999–2007). He studies epidemiology of P. falciparum, P. vivax and P. malariae; assessed malaria burden in urban and mining areas. He headed the WHO Pesticide Evaluation Scheme (2009–2018) and recommended new products (e.g. long-lasting insecticidal nets); their use has reduced global malaria burden in recent years. He has created a global network of laboratories for research. He has supported an academic course in public health entomology in India and trained >350 senior staff for malaria, dengue and kala-azar control. He is the editor, contributor and author of many WHO guidelines and training manuals in vector control. He has received a life-time achievement award and other awards for his national and international leadership, and scientific and public health contributions.

Proposer: Dr. R.C. Dhiman, Seconder: Dr. Neena Valecha


1. Van den Berg H., R. S. Yadav, M. Zaim (2015) Setting International Standards for the Management of Public Health Pesticides. PLoS Medicine 12(5): e1001824. doi:10.1371/journal.pmed.1001824 (IF=11.675, C=2) (if=11.675, ci=2)

2. Baeza A., M. J. Bouma, R. C. Dhiman, E. B. Baskerville, P. Ceccato, R. S. Yadav and M. Pascual (2013). Long-lasting transition toward sustainable elimination of desert malaria under irrigation development. PNAS, www.pnas.org/cgi/doi/10.1073/pnas.1305728110.(if=9.504, ci=20)

3. Van den Berg, H., M. Zaim, R. S. Yadav, A. Soares, B. Ameneshewa, A. Mnzava, J. Hii, A. P. Dash, M. Ejov (2012). Global trends in the use of insecticides to control vector-borne diseases. Environmental Health Perspectives, 120(4): doi:10.1289/ehp.1104340 or http://dx.doi.org/10.1289/ehp. 1104340. (if=8.309, ci=121)

4. Matthews, G., M. Zaim, R. S. Yadav, A. Soares, J. Hii, B. Ameneshewa, A. Mnzava, A.P. Dash, M. Ejov, S.H. Tan, H. van den Berg (2011). Status of legislation and regulatory control of public health pesticides in countries endemic with or at risk of major vector-borne diseases. Environmental Health Perspectives, 119 (11): doi:10.1289/ehp.1103637. (if=8.309, ci=35)

5. Laneri, K., A. Bhadra, E.L. Ionides, M. Bouma, R.C. Dhiman, R. S. Yadav, M. Pascual (2010). Forcing versus feedback: epidemic malaria and monsoon rains in NW India. PLoS Computational Biology, 6(9):e1000898. doi:10.1371/journal.pcbi.1000898. (if=3.955, ci=125)

6. Prajapati SK, A. Verma, T. Adak, R. S. Yadav, A. Kumar, A. Eapen, M.K. Das, N. Singh, S.K. Sharma, M.A. Rizvi, AP Dash, H. Joshi (2006). Allelic dimorphism of Plasmodium vivax gam-1 in the Indian subcontinent. Malaria Journal, 5:90. doi:10.1186/1475-2875-5-90. (IF=2.845, C=20) (if=2.845, ci=20)

7. Dunne MW, N. Singh, M. Shukla, N. Valecha, P.C. Bhattacharya, K. Patel, M.K. Mohapatra, J. Lakhani, C. Usa Devi, T. Adak, V. Dev, R. S. Yadav, C. Lele, K. Patki (2005). A double-blind, randomized study of Azithromycin compared to chloroquine for the treatment of Plasmodium vivax malaria in India. Am. J. Trop. Med. Hyg., 73(6): 1108-1111. (if=2.564, ci=37)

8. Yadav, R. S., R.M. Bhatt, V.K. Kohli and V.P. Sharma (2003). The burden of malaria in Ahmedabad city, India- a retrospective analysis of reported cases and deaths. Annals of Tropical Medicine & Parasitology, 97(8): 793-802. https://doi.org/10.1179/000349803225002642. (if=1.203, ci=37)

9. Yadav, R. S., H.C. Srivastava, T. Adak, N. Nanda, B. R. Thapar, C. S. Pant, M. Zaim and S. K. Subbarao (2003). Randomized House-scale Trial of Bifenthrin Indoor Residual Spraying for malaria Vector Control in India. Journal of Medical Entomology, 40(1): 58-63.(if=1.968, ci=20)

10. Yadav, R. S. and S.K. Ghosh (2002). Radical curative efficacy of five-day regimen of primaquine for treatment of Plasmodium vivax malaria in India. Journal of Parasitology, 88: 1042-44. (if=1.395, ci=25)

309

ACHAMVEETTIL, GOPALAKRISHNAN (b 1962), Director, ICAR-Central Marine Fisheries Research Institute, Kochi – 682 018, Kerala


Dr. Gopalakrishnan has contributed significantly to the genetic stock Identification (GSI), species inventory, taxonomy and breeding and seed production of threatened and maricultural important species throughout his 30 year career period, from Scientist at the National Bureau of Fish Genetic Resources, Lucknow to the Director, Central Marine Fisheries Research Institute (CMFRI), Kochi. His major scientific contributions are as follows: Distinct genetic stocks of 18 commercially important fish species identified. Developed 140 polymorphic Microsatellite markers (STRs) and species-specific DNA markers in 23 finfish, shellfish species; and whole mtDNA sequence of 5 fishes DNA Barcodes developed for 111 elasmobranchs and 356 teleosts and shellfish. Developed 4 cross-bred varieties of marine ornamental clown fish. Technique for forensic identification of meat of endangered whale shark and dugong developed using species-specific DNA markers. Milt cryopreservation and captive breeding protocols developed for six threatened fish species. Formulated green certification guidelines of native freshwater ornamental fishes from India. Seven fish cell lines developed for use in viral disease studies and vaccine development in marine finfish. Described two new fish species from Indian waters. Significantly contributed in developing three nutraceuticals against Hypothyroidism, Diabetes type II, Obesity & Hyper Cholesterolemia from the bioactive leads isolated from the seaweeds. Co-ordinated the Marine Fisheries Census of India (2016) covering 4057 fishing villages and 1281 fish landing centres/harbours. Fixed the minimum legal size for 58 species of commercially important fishes (Gazette notified by Govt. of Kerala in 2017). Developed the guidelines for sea-cage farming in India as Chairman of the national committee.

Proposer: Dr. W.S. Lakra, Seconder: Dr. Rattan Lal Yadav


1. Anil M.K., Gomathi P., Sugi V.V., Raheem P.K., Raju B., Ambarish P. Gop, Santhosh B., Philipose K.K., Gopakumar G., Gopalakrishnan A., 2019, Captive maturation, breeding and seed production of Pink ear emperor, Lethrinus lentjan (Lacepede, 1802) (Family: Lethrinidae) in recirculating aquaculture system (RAS), Aquaculture, 503: 207-216 https://doi.o (if=2.978)

2. Divya, P. R., Mohitha, C., Rahul, G. K., Shanis, C. P. R., Basheer, V. S., & Gopalakrishnan, A. , 2017, Molecular Phylogenetics and Evolution Molecular based phylogenetic species recognition in the genus Pampus ( Perciformes : Stromateidae ) reveals hidden diversity in the Indian Ocean., Molecular Phylogenetics and Evolution, 109, 240–245. https:// (if=4.419, ci=4)

3. Bineesh, K. K., A. Gopalakrishnan, K. V. Akhilesh, K. A. Sajeela, E. M. Abdussamad, N. G. K. Pillai, V. S. Basheer, J. K. Jena and Robert D. Ward , 2017, DNA barcoding reveals species composition of sharks and rays in the Indian commercial fishery., Mitochondrial DNA Part A, 28(4): 458-472, http://dx.doi.org/10.3109/19401736.2015.1137900. (if=3.35, ci=29 )

4. Kumar, Raj, Gopalakrishnan, A., Divya, P.R., Basheer, V.S., Singh, Rajeev K., Mohindra, Vindya, Lal, Kuldeep K., Jena, J.K., 2017, Population genetic structure of Macrobrachium rosenbergii (Palaemonidae) from Indian waters using mitochondrial ATPase 6/8 gene, Mitochondrial DNA Part A, 28 (4) 602-605 (if=3.35, ci=14)

5. Jeena N. S., A. Gopalakrishnan, E. V. Radhakrishnan, Joe K. Kizhakudan, V. S. Basheer, P. K. Asokan and J. K. Jena , 2016, Molecular phylogeny of commercially important lobster species from Indian coast inferred from mitochondrial and nuclear DNA sequences. , Mitochondrial DNA (A) DNA Map Seq Anal., 27(4):2700-2709. DOI: 10.3109/19401736.2015.104 (if=3.35, ci=12)

6. Joy Linu, C. Mohitha, P. R. Divya, A. Gopalakrishnan, V. S. Basheer, and J. K. Jena , 2016, Weak genetic differentiation in cobia, Rachycentron canadum from Indian waters as inferred from mitochondrial DNA ATPase 6 and 8 genes., Mitochondrial DNA A DNA Mapp Seq Anal. 27(4): 2819-2821, DOI: 10.3109/19401736.2015.1053083. (if=3.35, ci=5)

7. Lakra, W. S., Singh, M., Goswami, M., Gopalakrishnan, A., Lal, K.K., Mohindra, V., Sarkar, U.K., Punia, P.P., Singh, K.V., Bhatt, J.P.,, 2016, DNA barcoding Indian freshwater fishes, Mitochondrial DNA Part A 27 (6) 4510-4517 (if=3.35, ci=4 )

8. Divya, P. R. , Gopalakrishnan, A., Basheer, V.S., Swaminathan, Raja, Mohitha, C., Joy, Linu, Kumar, Raj, Manoj, P., Jena, J.K., 2015, Mitochondrial ATPase 6/8 genes to infer the population genetic structure of silver pomfret fish Pampus argenteus along the Indian waters, Mitochondrial DNA, 26 (2) 189-194 (if=3.35, ci=5)

9. Balasubramanian C. P., Cubelio S. S., Mohanlal D. L, Ponniah A. G., Raj Kumar, Bineesh K. K., Ravichandran P., Gopalakrishnan A., Mandal A., and. Jena J. K. , 2014, DNA sequence information resolves taxonomic ambiguity of the common mud crab species (Genus Scylla) in Indian waters. , Mitochondrial DNA A DNA Mapp Seq Anal. 2016; 27(1):270-5. DOI: 10 (if=3.35, ci=6)

10. Lakra, W. S., Verma, M.S., Goswami, Mukunda, Lal, Kuldeep Kumar, Mohindra, Vindhya, Punia, P., Gopalakrishnan, A., Singh, K.V., Ward, Robert D., Hebert, Paul, 2011, DNA barcoding Indian marine fishes, Molecular Ecology Resources, 11 (1) 60-71 (if=7.332, ci=170)

310

BANDYOPADHYAY, PROBIR KUMAR (b 1959), Professor, Department of Zoology, University of Kalyani, Kalyani


Prof. P. K. Bandyopadhyay has been nominated as a member of NASI in the year 2014. His work has centred on the identification, taxonomy, systematic of protozoan parasites of many invertebrate and vertebrate hosts. Apart from this he had been able to bring a breakthrough research finding in showing an alternate way of controlling fish disease by locally available medicinal plant extracts. His research has been proved to be very significant for the development of aquaculture industry. He has identified a significant number of protozoan parasites causing mass mortality of aquarium fish. He did a lot of research on identification of protozoan parasites of annelids. Apart from protozoan parasites he has also contributed a lot in the field of helminthology. During his career 31 students have been awarded Ph.D. degrees along with 2 M.Phil. degrees. He has published more than 190 research papers on different fields of taxonomy, systematic, molecular taxonomy, phylogeny, disease biology, control of diseases by medicinal plant biomolecules. He has supervised 9 major projects funded by DST (India), DBT (India), ICAR, DST (W.B.), University of Kalyani as the principal investigator and along with many minor projects. In 2018 he has been awarded an Indo-Hungarian collaborative research project with his counterpart in Hungary by DST (India). He has visited many countries for training programs, attending seminars/symposia including Bangladesh, China, Australia, Spain, South Korea. He has successfully organized three numbers of national and international seminars in the capacity of Organizing Secretary and edited three numbers of Proceedings.

Proposer: Prof. Wasim Ahmad, Seconder: Dr. Himanshu Pathak


1. Ghosh, S. Bandyopadhyay, P.K. (2019) Molecular characterization of newly identified Klebsiella PKBSG14 and analysis of its effect on immune response and cell cycle progression using common catfish (Channa punctatus) as a model. Microbial pathogenesis 368-379(if=2.332, ci=-)

2. Saha,M., Bandyopadhyay, P.K.,(2018) Molecular characterization of a novel Thelohanellus species (Myxosporea: Myxobolidae) infecting the fins of Goldfish, Carassius auratus L. with special reference to its histopathological alteration, Acta Tropica. Elsevier, 181:25-34, IF- 2.5 (if=2.509, ci=02)

3. Saha,M., Bandyopadhyay, P.K.,(2018) Identification of a new myxosporean parasiteThelohanellus indianan. sp. (Myxosporea: Myxobolidae) isolated from three major organs of goldfish, Carassius auratusL. highlighted with its morphological and SSU rDNA sequence based molecular description, Microbial Pathogenesis, Elsevier, 122, 191–199, (if=2.332)

4. Ghosh,S., Saha, M., Bandyopadhyay, P.K (2017). Extraction, Isolation and Characterization of Bioactive Compounds from chloroform extract of Carica papaya seed and it’s in vivo antibacterial potentiality in Channa punctatus against Klebsiella PKBSG14. Microbial Pathogenesis, Elsevier, DOI: 10.1016/j.micpath.2017.08.033. IF- 2.2 (if=2.332, ci=02)

5. Saha, M., Bandyopadhyay, P.K.(2017) Phytochemical screening for identification of bioactive compound and antiprotozoan activity of fresh garlic bulb over trichodinid ciliates affecting ornamental goldfish. Acquaculture 473, 181-190 (if=2.710, ci=11)

6. Saha, M., Bandyopadhyay, P.K (2016): First report of some known Trichodinella epizootica Šramek-Hušek, 1953, and Tripartiella Lom, 1959 from the cultured Oranda Gold Fish (Carassius auratus auratus) in India (if=0.931, ci=6)

7. Saha, M., Bandyopadhyay, P.K (2016) Studies on histopathological alteration of three major organs of the goldfish,Carassius auratus L., of India due to myxozoan infection with special reference to scanning electron microscopic observation. Parasitology Research. DOI 10.1007/s00436-016-5314-9. (if=2.558, ci=5)

8. Mitra, A., Bandyopadhyay, P.K., Gong, Y. (2012) Studies on trichodinid and chilodonellid Ciliophorans (Protozoa:Ciliophora) in the Indian freshwater and estuarine fishes with description of Trichodinella sunderbanensis sp.nov.and Trichodina nandusi sp.nov. Parasitol Res (Springer) DOI 10.1007/S00436-012-3234 (if=2.558, ci=11)

9. Mitra, A.K., Bandyopadhyay, P.K. (2005). “Trichodina haldari sp. n. and Paratrichodina bassonae sp. n. (Ciliophora: Peritrichida) from Indian fresh water fishes”. Act Protozool. 45: 289 – 294 (if=1.491, ci=16)

10. Bandyopadhyay, P. K., Roychoudhuri, U. S., Biswas,G. 2004. Descriptions of two new species of acephaline gregarines (Protozoa:Apicomplexa: Eugregarinida) Apolocystis chotonagpurensis sp.n. and Stomatophora janovyi sp.n. from earthworms (Annelida:Oligochaeta:Haplotaxodida) of India. Act Protozool.. 43: 275 - 279. (if=1.491, ci=12)

311

BHADURY, PUNYASLOKE (b 1979) Associate Professor, Indian Institute of Science Education and Research Kolkata


Taxonomic intractability is one of the major problems in metazoan groups that inhabit terrestrial and marine domains. The candidate has effectively used molecular tools to resolve taxonomic intractability in one of the metazoan groups represented by the Phylum Nematoda. Prof. Bhadury has developed DNA barcoding as an effective tool for rapid identification of free-living nematodes across marine realms and for the first time addressed and resolved long standing question in biogeography, in particular cosmopolitan distribution of marine benthic metazoans using molecular microbial tools (Bhadury et al 2006a, Bhadury et al 2006b, Bhadury et al 2008) which could be highly useful for understanding delineating metazoan evolution. More recently, he has conclusively shown that marine phytoplankton are more diverse and harbor cryptic species in global ocean basins that previously thought of and many of these species are unknown from the viewpoint of ecophysiology and resulting coastal primary production (Samanta and Bhadury 2016; Singh and Bhadury 2018 in press). One of the long standing questions pertaining to biogeochemical cycling of arsenic which has immense human health implications in the Bengal Delta Plains (BDP) has been addressed by him. He has now clearly proved the long standing hypothesis, that arsenic mobilization and subsequent contamination of ground water aquifers with As is controlled by dissolved organic carbon pool, in particular petroleum hydrocarbons (Ghosh et al 2015a, 2015b).With robust experimental evidence he has now shown that arsenite oxidizing bacteria which are key to controlling As toxicity are indeed present in BDP aquifers and that they require DOC for biotransformation of As species (e.g. Ghosh et al 2014, Ghosh et al 2015b, Ghosh et al 2017).

Proposer : Prof. Tapas K. Kundu, Seconder : Prof. Anuranjan Anand

Ten Best Publications: 1. Debnath M and Bhadury P (2016) Adaptive responses and arsenic transformation potential of diazotrophic Cyanobacteria isolated from rice fields of arsenic affected Bengal Delta Plain. Journal of Applied Phycology 28: 2777-2792 (if=2.616; ci=5) 2. Land P, Jamie S, Findlay H, Girard-Ardhuin F, Sabia R, Reul N, Piolle J-F, Bertrand C, Quilfen Y, Salisbury J, Vandemark D, Bellerby R and Bhadury P (2015) Salinity from space unlocks satellite-based monitoring of ocean acidification. Environmental Science and Technology DOI: 10.1021/es504849s (if=6.198; ci=23) 3. Ghosh D, Routh J and Bhadury P (2015a) Elemental and biomarker characteristics ina Pleistocene aquifer vulnerable to arsenic contamination in the Bengal Delta Plain, India. Applied Geochemistry 61: 87-98 (if=2.581; ci=13) 4. Ghosh D, Routh J and Bhadury P (2015b) Characterization and microbial utilization of dissolved lipid organic fraction in arsenic impacted aquifers (India). Journal of Hydrology 527: 221-233 (if=3.483; ci=13) 5. Ghosh D, Bhadury P and Routh J (2014) Diversity of arsenite oxidizing bacterial communities in arsenic-rich deltaic aquifers in West Bengal, India. Frontiers in Microbiology DOI: 10.3389/fmicb.2014.00602 (if=4.076; ci=18) 6. Samanta B and Bhadury P (2014) Analysis of diversity of chromophytic phytoplankton in a mangrove ecosystem using rbcL gene sequencing. Journal of Phycology 50:328-340 (if=2.608; ci=12) 7. Bhadury P, Austen MC, Bilton DT, Lambshead PJD, Rogers AD and Smerdon GR (2008) Evaluation of combined morphological and molecular techniques for marine nematode (Terschellingia spp.) identification. Marine Biology 154: 509-518 (if=2.136; ci=69) 8. Bhadury P, Austen MC, Bilton DT, Lambshead PJD, Rogers AD and Smerdon GR (2006a) Molecular detection of marine nematodes from environmental samples: overcoming eukaryotic interference. Aquatic Microbial Ecology 44: 97-103 (if=2.109; ci=37) 9. Bhadury P, Austen MC, Bilton DT, Lambshead PJD, Rogers AD and Smerdon GR (2006b) Development and evaluation of a DNA barcoding approach for the rapid identification of nematodes. Marine Ecology Progress Series 320: 1-9 (if=2.292; ci=127) 10. Bhadury P and Wright PC (2004) Exploitation of marine algae: biogenic compounds for potential antifouling applications Planta 219: 561-578 (if=3.361; ci=248)

312

CHAUHAN, MANMOHAN SINGH (b 1960), Director, ICAR-Central Institute for Research on Goats, Makhdoom, Mathura


Dr.Manmohan Singh Chauhan, Director, ICAR-Central Institute for Research on Goats, Makhdoom, Mathura (UP). Dr. Chauhan is a Distinguished Scientist in the field of Reproductive Biotechnology of Livestock. He has devepoped simple method for In vitro production (IVF) of embryos in cattle, buffalo, goat and yak; production of embryonic stem cell lines in buffalo and goat; ovum pick up (OPU) - IVF technology in cattle and yak; animal cloning in buffalo using simple hand guided cloning technology. These technologies have implemented in animal farm and brought name and fame to ICAR and the country by producing several IVF buffaloes and cloned buffaloes. He is ‘Fellow of National Academy of Agricultural Sciences’, ‘Fellow of National Academy of Dairy Sciences of India’, Principal Investigator of 11 mega projects, granted over 13 crore, guided 10 Doctoral students, organised 3 conferences. He has been recipient of Rafi Ahmed Kidwai Award (ICAR); DBT Overseas Long Term Associate ship Award; ICAR-Team Award; Dr. Rao Bahadur B Viswanath Award, 2016-17 by IARI, New Delhi; Dr. Labhsetwar Award, ISSRF; Certificate of Merit Award for Exemplary Research, Virginia Tech, USA; Prof. G.P. Talwar Middle Career Scientist Award by ISSRF. Over 125 research papers, approximately 90 scientific and technical publicationshave been published by him. He has visited USA, Canada and Germany. He was recognized as Kisano ke Mahanayak by DD Kisan, New Delhi.

Proposer: Dr. Dheer Singh, Seconder: Prof. S. S. Mazumdar


1. Chauhan MS, Singla SK, Palta P, Manik RS, Madan ML. 1998. In vitro maturation and fertilization, and subsequent development of buffalo (Bubalus bubalis) embryos: effects of oocyte quality and type of serum. Reprod Fertil Dev.;10(2):173-7. (if=2.135, ci=127)

2. Chauhan MS, Palta P, Das SK, Katiyar PK, Madan ML. 1997. Replacement of serum and hormone additives with follicular fluid in the IVM medium: effects on maturation, fertilization and subsequent development of buffalo oocytes in vitro. Theriogenology. 48(3):461-9.(if=2.136, ci=57)

3. Chauhan MS, Anand SR. 1990. Effect of egg yolk lipids on the freezing of goat semen. Theriogenology. Nov;34(5):1003-13 (if=2.136, ci=55)

4. . Chauhan, M. S., Nadir, S., Bailey, T. L., Pryor, A. W., Butler, S. P., Notter, D. R., . . . Gwazdauskas, F. C. (1999). Bovine follicular dynamics, oocyte recovery, and development of oocytes microinjected with a green fluorescent protein construct. Journal of Dairy Science, 82(5), 918-926. (if=2.749, ci=32)

5. . Chauhan MS, Kapila R, Gandhi KK, Anand SR. 1994. Acrosome damage and enzyme leakage of goat spermatozoa during dilution, cooling and freezing. Andrologia. 26(1):21-6. (if=2.734, ci=37)

6. Nandi, S., Raghu, H. M., Ravindranatha, B. M., &Chauhan, M. S*. (2002). Production of buffalo (Bubalus bubalis) embryos in vitro: Premises and promises. Reproduction in Domestic Animals, 37(2), 65-74 (if=1.422, ci=85)

7. Verma, V., Gautam, S. K., Singh, B., Manik, R. S., Palta, P., Singla, S. K., . . . Chauhan, M. S*. (2007). Isolation and characterization of embryonic stem cell-like cells from in vitro-produced buffalo (Bubalus bubalis) embryos. Molecular Reproduction and Development, 74(4), 520-529. (if=3.113, ci=74)

8. Nandi S, Chauhan MS, Palta P. 1998. Influence of cumulus cells and sperm concentration on cleavage rate and subsequent embryonic development of buffalo (Bubalus bubalis) oocytes matured and fertilized in vitro. Theriogenology. 50(8):1251-62. (if=2.136, ci=66)

9. . Palta P, Chauhan MS*. 1998. Laboratory production of buffalo (Bubalus bubalis) embryos. Reprod Fertil Dev. 10(5):379-91. (if=2.135, ci=58)

10. George A, Sharma R, Singh KP, Panda SK, Singla SK, Palta P, Manik R, Chauhan MS*. 2011. Production of cloned and transgenic embryos using buffalo (Bubalus bubalis) embryonic stem cell-like cells isolated from in vitro fertilized and cloned blastocysts. Cell Reprogram. 13(3):263-72. doi: 10.1089/cell.2010.0094. (if=1.92, ci=36)

313

DINESH, DIWAKAR SINGH (b 1959), Scientist E, ICMR- Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna


Dr. Diwakar Singh Dinesh is pursuing research on sandfly vector; Phlebotomus argentines (Diptra: Psychodidae) of Kala-azar since last 32 years. He has contributed in biology and control of sandflies and established several facts like landing and biting rhythm of P. argentipes on human and cattle hosts and mid night was found peak biting period, plant sources of fructose to sandflies, insecticidal effect of plant extracts, resistance against DDT to sandflies, LLIN to control sandflies up to 24 per cent, protection from Leishmania donovani infection by sandflies saliva, morphological variations in P. argentipes complex, xenodiagnosis of P. argentipes by DNA probe hybridisation, CDC light trap as potential sandfly collection device, control of sandfly by environmental manage-ment method by skirting indoor walls with brick chimney fly ash and lime and supporting Bihar state during outbreaks of different vector borne diseases like Malaria, JE, Dengue, AES, etc. He has supervised three PhD students and has 52 research publications in different National and International peer reviewed journals and 11 articles/chapters in books and 2 in bulletins. He has completed several National and International research projects. He is life member of several National and International scientific associations. He is a recipient of ICMR Senior Scientist Fellowship 2015. He has been elected as a fellow of the Indian Society of Malaria and Other Communicable Diseases (FISCD)-2017. He has been awarded with ‘Nan Lal Kalra award-2019’ by National Academy of Vector Borne Diseases Bhubaneswar, India for his distinguished contribution in entomological field research in 2019.

Proposer: Prof. Madhav Gadgil, Seconder: Dr. Vishwa Mohan Katoch


1. Dinesh DS, Das ML, Picado A, Roy L, Rijal S, Singh SP, Das P, Boelaert M & Coosemans M (2010) Insecticide Susceptibility of Phlebotomus argentipes in Visceral Leishmaniasis Endemic Districts in India and Nepal. PLoS Negl Trop Dis4 (10): e859 (if=4.367, ci=61)

2. Picado A, Das ML, Kumar V, Keshari S, Dinesh DS, Roy L, Rijal S, Das P, Rowland M, Sundar S, Coosemans M, Boelaert M & Davies C (2010). Effect of village-wide use of Long-Lasting Insecticidal Nets on visceral leishmaniasis vectors in India and Nepal: a cluster randomized trial. PLOS Neglected Tropical Diseases, 4(1): e587 (1-9). (if=4.367, ci=61)

3. Dinesh DS, Kumari S, Hassan F, Kumar V, Singh VP and Das P (2017). Efficacy and evaluation of environmental management system to control sandfly vector of Kala-azar, Journal of Environmental Management, 201:366-368. (if=4.005, ci=0)

4. Bart O, Vanlerberghe V, Picado A, Dinesh DS, Sunder S, Chappuis F, Rijal S, Dujardin JC, Cossemans M, Boelart M & Davies C (2008). Vector control by insecticide-treated nets in the fight against visceral leishmaniasis in the Indian subcontinent, what is the evidence? Tropical Medicine and International Health, 13 (8): 1-13. (if=2.541, ci=78)

5. Clements MF, Gidwani K, Kumar R, Hostomska J, Dinesh DS, ….,Rogers ME (2010). Measurement of recent exposure to Phlebotomus argentiopes, the vector of Indian Visceral Leishmaniasis,by using human antibody responses to sand fly saliva American Journal of Tropical Medicine and Hygiene, 82 (5) 801-807. (if=2.564, ci=57)

6. Dinesh DS, Das P, Picado A, Davies C, Speybroeck N, Bart O, Boelart M & Coosemans M (2008). Long–lasting insecticidal nets fail at household level to reduce abundance of sand fly vector Phlebotomus argentipes in treated houses in Bihar, (India). Tropical Medicine and International Health 13(7): 953-958. (if=2.541, ci=45)

7. Kishore K, Kumar V, Kesari S, Dinesh DS, Kumar AJ, Das P & Bhattacharya SK (2006). Vector Control in Leishmaniasis. Indian Journal of Medical Research, 123: 467 – 472. (if=1.508, ci=121)

8. Dinesh D S, Ranjan A, Palit A, Kishore K & Kar SK (2001). Seasonal and nocturnal landing/biting behavior of Phlebotomus argentipes (Diptera: Psychodidae). Annals of tropical Medicine & Parasitology, 95: 197-202. (if=1.203, ci=68)

9. Dinesh DS, Kar SK, Kishore K, Palit A, Verma N, Gupta AK, Chauhan DS, Singh D, Sharma V D & Katoch VM (2000).Screening sand flies for natural infection with Leishmania donovani, using a non-radioactive probe based on the total DNA of the parasite. Annals of Tropical Medicine & Parasitology,94: 447-451 (if=1.203, ci=37)

10. Dinesh DS, Das P, Picado A, Davies C, Speybroeck N, Boelart M & Coosemans M (2008). The efficacy of indoor CDC light traps for collecting the sandfly Phlebotomus argentipes, vector of Leishmania donovani. Medical and Veterinary Entomology 22:120-123 (if=1.688, ci=34)

314

GUPTA, NEELIMA (b 1955), Professor & Dean Students Welfare, MJP Rohilkhand University, Bareilly


PROF. (MRS) NEELIMA GUPTA, National (1) & State (2) Awardee is an internationally acclaimed taxonomist (blood parasites specific, parasites in general). Several species have been dedicated in her name. Her innovative contributions on morpho-taxonomy, molecular taxonomy, protein profile and scanning electron microscopy are based on 60 species of 22 genera (50 new species, 3 sub species) making her the recipient of the PRESTIGIOUS LIFE TIME NATIONAL AWARD, EK JANAKI AMMAL NATIONAL AWARD ON ANIMAL TAXONOMY (Ministry of Environment & Forests, Government of India). She is the recipient of more than 38 awards including 2 state awards (Vigyan Ratna and Dr. SAH Abidi Krishi Vaigyanik Puraskar). She has published several papers with leading global scientists. She was awarded the “Centre of Excellence” by the State Government and has executed research projects worth Rs. 1.3 crores. She was invited as Lead Speaker in many national and international conferences (George Washington University, USA, Poland, Egypt, Japan, Singapore, China) and became a global leader having international collaborations with five continents of the globe. She is presently working on fish fauna of river Ramganga (UPCAR research project). Her contributions have unfolded many mysteries of parasites and have greatly benefitted fish farmers and scientists. She has a research experience of 40 years, contributing 6 books, 175 research papers, 300 abstracted in conferences (481). She has presented her findings in 135 symposia (26 international, 109 national). Based on my personal knowledge of her own merits and expertise, she has my strong recommendations.

Proposer: Prof. M Shamim Jairajpuri, Seconder: Prof. Wasim Ahmad


1. Gupta, Neelima & Jairajpuri, D. S. (1982): Trypanosoma aligaricus n. sp. from the freshwater murrel, Ophiocephalus punctatus Bloch. Arch. Protistenkd., 125: 109-114. (If=3.045 JCR, 9.05 NAAS, ci=2).

2. Gupta, Neelima & Jairajpuri, D. S. (1983): Trypanosoma batrachi Qadri, 1962 and its effect on the biochemical composition of the blood of Clarias batrachus. Acta Protozool., 22:79-85. (if=1.491 JCR, 1.96 Research Gate,0.581 SJR, 28 H-Index, 6.84, NAAS, 148.36 ICV, ci=5).

3. Gupta, Neelima & Gupta, D. K. (1988): Prevalence of trypanosomes in freshwater fishes of Northern India: Cross transmission experiments on host specificity. Arch. Protistenkd., 136: 203-209 (if=3.045 JCR, 9.05 NAAS, ci=3).

4. Gupta, Neelima, Gupta, D. K. & Yadav, P. (1998): New records of some haemoparasites affecting Puntius ticto (Pisces: Cyprinidae) in India: Observations on interaction and displacement of species. Res. Rev. Parasitol. Spain. 58: 103-108. (If=1.129 JCR, 5.79 ICV, ci=2).

5. Gupta, Neelima and Bhaskar, Manju & Gupta, D.K. (2009): Gastro-intestinal invasion in Hemidactylus flaviviridis with a new species of Parapharyngodon. (Oxyuroidea: Parapharyngodonidae). Zootaxa. 2165: 39-51 (if=0.994 JCR, 1.16 Research Gate, 0.62 SJR, 6.91 NAAS, ci=9).

6. Gupta, D. K. & Gupta, Neelima (2010): A haemogram of Clarias batrachus parasitized by two species of haemoflagellates (Trypanosoma batrachi Qadri, 1962 and Trypanosoma haematalis n. sp.) as an indicator of infectivity. Reviews in Fish. Sc. 18(2): 17 (if=2.032 JCR, 2.54 Research Gate,7.87 NAAS, ci=2).

7. Gupta, Neelima and Bhaskar, Manju and Gupta, D.K. (2012): Macroenvironmental influence on Hepatozoon lacertilis infectivity to lizard Hemidactylus flaviviridis. J. Env. Biol., 33 : 127-132. (if=0.56 JCR, 0.31 SJR, 6.55 NAAS, ci=3).

8. Gupta, Neelima, Singhal, P. and Gupta, D.K. (2012): Population dynamics of Pallisentis (Acanthocephala) in relation to host sex of Channa. J. Env. Biol., 33: 195-199. (if=0.56 JCR, 0.31 SJR, 6.55 NAAS, ci=4).

9. Gupta, Neelima, Bhaskar, M, and Gupta, D.K. (2013): Ecological attributes of Hepatozoan lacertilis Gupta et al., 2011 susceptibility in Indian lizards, Hemidactylus flaviviridis (Gekkonidae) and Calotes versicolor (A (if=0.921 JCR, 0.46 SJR, 6.82 NAAS, ci=1).

10. Gupta, Neelima, Gupta, D.K., Singhal, P. (2015): Description of Pallisentis (Brevitritospinus) punctati n. sp. (Acanthocephala:Quadrigyridae) from Channa punctatus in Bareilly, Uttar Pradesh, India. Iran J Parasitol 10(4):605-616 (if=0.872 JCR, 6.69 NAAS, ci=1).

315

KRISHNAMOORTHY, VENKATARAMAN (b 1955), Former Director, Zoological Survey of India; Senior Scientific Consultant, National Centre for Sustainable Coastal Management, MOEFCC, Chennai


Dr Venkataraman has made significant contributions to animal taxonomy and in conservation of endangered animals of India. His discoveries on vertebrates and invertebrates especially coral associated fauna are of biomonitoring, evolutionary and conservation significance. His acclaimed work on coral taxonomy and associated fauna has been immensely contributing to taxonomy. He started his career in freshwater, migrated to river fauna and finally ended up in coastal and marine ecosystem. He is the first certified Dive Master in India and has been diving throughout the world since 1998. His pioneering underwater studies on Coral reefs have unravelled the Status and coral bleaching as well as corals after Tsunami. His study on marine biodiversity of India has led to consequential increase in marine biodiversity from 12,372 to 21,663 (coral in particular have increased from 218 in 1998 to 577 species in 2015) adding to an increase of fauna of India from 89451 to 100000+. With the aid of his Hand Book on Hard corals of India, he trained researchers and managers on status, taxonomy as well as underwater monitoring studies. His effort towards Coral restoration by transplantation in Gulf of Kachchh is a success story. This has made him a nationally and internationally renowned coral reef researcher. He has discovered a coral species new to science and 351 new records for India. Dr. Venkataraman’s researches have resulted in outstanding contributions to taxonomy, conservation and management of corals and associated marine animals in India and in shaping biodiversity conservation.

Proposer: Dr. Qaiser Husain Baqri, Seconder: Prof. Wasim Ahmad


1. Venkataraman, K. 1981. Field and Laboratory studies on Daphnia carinata Kind (Cladocera: Daphnidae) from a seasonal tropical pond, Hydrobiol., 78 (3): 221-225 (if=2.165, ci=16)

2. Venkataraman, K. and M. Wafar, 2005. Coastal and marine biodiversity of India, Indian J. Mar. Sci. 34 (1) 57-75 (if=0.289, ci=242)

3. Wafar,M. K Venkataraman, B Ingole, SA Khan, P LokaBharathi, 2011. State of knowledge of coastal and marine biodiversity of Indian Ocean countries, PLoS One 6 (1), e14613. (if=4.092, ci=72)

4. Venkataraman, K., C. Raghunathan, C. Satyanarayana, R. Rajkumar, 2016. Invasion of Snowflake Coral, Carijoa riisei (Duchassaing and Michelotti, 1860), in Indian Seas: Threats to Coral Reef Ecosystem, ISSN: 0975-1033; NISCAIR-CSIR, India IJMS Vol.45(1(if=0.289, ci=1)

5. N. Marimuthu, J.S.Y. Kumar, C Raghunathan, N.V. Vinithkumar, K. Venkataraman, 2017. North-south gradient of incidence, distribution and variations of coral reef communities in the Andaman and Nicobar Islands, India, J. Coast. Conservation 21 (2), 28 (if=0.957, ci=2)

6. Kumar, J.S.Y., C. Satyanarayana, K. Venkataraman, K. Chandra, 2017. Studies on survival and growth rate of transplanted Acroporidae in Gulf of Kachchh Marine National Park, India, J. Coast. Conserv. 21 (1): 23-34. (if=1.160, ci=1.)

7. Mondal, T., C Raghunathan, K Venkataraman, 2017. First report of four species of azooxanthellate scleractinian corals in Indian waters from Andaman and Nicobar Islands Indian Journal of Geo Marine Sciences (NISCAIR-CSIR), India 46 (08): 1627-1631 (if=4.37, ci=2)

8. Purushothaman, J., S. Hansda, J. Dey, S. Mohan, A. Basu and K. Venkataraman, 2017. An annotated checklist of Thaliaceans (Chordata: Tunicates) Marine Biodiversity, ISSN 1867-1616; DOI 10.1007/s12526-017-0698-z 1-28 (if=1.646, ci=3)

9. Kalyan De, K. Venkataraman, B. Ingole, 2017. Current status and scope of coral reef research in India: A bio-ecological perspective , Indian Journal of Geo Marine Sciences, NISCAIR-CSIR, India46(4): 647-662. (if=0.534, ci=3)

10. Krishnan, P., R. Purvaja, CR. Sreeraj, R. Raghuraman, R.S. Robin, KR. Abhilash, RS. Mahendra, A. Anand, M. Gopi, PC. Mohanty, K. Venkataraman and R. Ramesh, 2018. Differential bleaching patterns in corals of Palk Bay and the Gulf of Mannar. Curr. Sci (if=0.883, ci=1)

316

KUMAR, PRADEEP G. (b 1962), Scientist G, Rajiv Gandhi Centre for Biotechnology, Thycaud PO, Poojappura, Thiruvananthapuram 605014, Kerala


He demonstrated the presence and reorganizations of detergent-resistant microdomains (membrane rafts) in sperm membranes during epididymal maturation, capacitation and acrosome reaction and that these membrane modifications are dependent on plasma membrane located NOX system. He also showed that defective expression of NOX and several raft-associated proteins in spermatozoa is associated with human male factor infertility and that neutralizing NOX can interfere with sperm functioning in fertile men. He generated proteome profiles of raft and non-raft proteins of human sperm and identified strong association between the absence of any of the 19 critical proteins identified by him and male factor infertility. He has developed a prototype protein-chip for molecular diagnosis of male factor infertility. Using the 1st wave of spermatogenesis in mouse as a model, he has generated epigenetic, transcriptome, mirnome and proteome during the onset and progression germline stem cell differentiation in testis and have identified key pathways and regulatory molecules involved in the processes of gernline stem cell maintenance, initiation of differentiation and meiotic entry. He has develop technology for trans-differentiation of spermatogonial stem cell into embryonic stem cell like (ES-like) cells, which could further be converted into ectodermal, mesodermal and endodermal lineages in culture. At present, he is targeting select miRNAs to alter the expression level of several genes in one go and to reprogram germline stem cells in culture to produce haploid cells in vitro.

Proposer: Prof. G.P. Talwar, Seconder: Prof. K. Muralidhar


1. Kumar GP, Seerwani N, Laloraya M, Nivsarkar M, Verma S and Singh A (1990) Superoxide dismutase as a regulatory switch in mammalian testicular steroidogenesis. Biochem. Biophys. Res. Commun. 173(1), 302 308. (if=3.25, ci=28)

2. Kumar GP, Laloraya M and Laloraya MM (1991) Superoxide radical level and superoxide dismutase activity changes in maturing mammalian spermatozoa. Andrologia 23(2), 171 175. (if=1.630, ci=33)

3. Kumar GP, Malini Laloraya, Cong-Yi Wang, Quin-Guo Ruan, Abdoreza Davoodi-Semiromi, Kuo-Jang Kao, and Jing-Xiong She (2001) The Autoimmune Regulator (AIRE) Is a DNA-binding Protein J. Biol. Chem., Vol. 276, Issue 44, 41357-41364. (if=6.56, ci=155)

4. Shukla S, Jha RK, Laloraya M and Kumar GP (2005) Identification of non-mitochondrial NADPH oxidase and the spatio-temporal organization of its components in mouse spermatozoa. Biochem. Biophys. Res. Commun. 331(2), 476-483. (if=3.25, ci=29)

5. Sreesha S, Radhakrishnan K, Indu S and Kumar PG (2014) Dramatic changes in 67 microRNAs during Initiation of first wave of spermatogenesis in Mus musculus testis: Global regulatory insights generated by microRNA-mRNA network analysis. Biol. Reprod. 91 (3) 69, 1-11. (if=3.471, ci=14)

6. Devi AN, Kumar ATR, Pillai SM, Jayakrishnan K and Kumar PG (2015) Expression profiles of NPHP1 in the germ cells in the semen of men with male factor infertility. Andrology 3, 685-693 (if=2.515, ci=2)

7. Indu S, Sekhar SC, Jeeva S, Anilkumar TR, Pillai SM, Laloraya M and Kumar PG (2015) Aberrant expression of DYNLT1 is associated with human male factor infertility. Mol Cell Proteom 14(12):3185-95 (if=6.564, ci=2)

8. Varghese DS, Chandran U, Soumya A, Pillai SM, Jayakrishnan K, Reddi PP and Kumar PG (2016) Aberrant expression of TAR DNA binding protein-43 is associated with spermatogenic disorders in human males. Reprod. Fertil. Dev. 28(6):713-22 (if=2.583, ci=6)

9. Chandran U, Indu S, Anilkumar TR, Devi AN, Khan I, Srivastava D and Kumar PG (2016) Expression of Cnnm1 and its association with stemness, cell cycle and differentiation in spermatogenic cells in mouse testis. Biol. Reprod 95(1), 7 (if=3.471, ci=3)

10. Radhakrishnan K, Bhagya KP, Anilumar TR, Devi AN, Sengottaiyan J and Kumar PG (2016) Autoimmune regulator (AIRE) is expressed in spermatogenic cells and it altered the expression of several nucleic acid binding and cytoskeletal proteins in GC1-spg spermatogonial cells. Mol Cell Proteomics 15(8), 2686-2698. (if=6.564, ci=2)

317

MUKHOPADHYAY, ARNAB (b 1972), Staff Scientist V, National Institute of Immunology, New Delhi


Aging predisposes humans to age-related diseases like diabetes, cancer and neurodegenerative disorders. Understanding its molecular basis is key to develop interventions that will prevent these diseases and prolong healthy lifespan. Arnab started his lab in NII around ten years ago. Having a strong background in aging biology, Arnab has used a unique combination of genetics, cell biology and genomics to understand how nutrient signaling controls lifespan and modulate aging. He is also one of the few Indian PIs who use Caenorhabditis elegans as a model system. He has identified novel genes that when knocked down convinces animals to believe that food is limiting, even under food-replete condition, to mount a conserved cytoprotective response leading to increased longevity. He has elucidated the complex transcriptional and posttranscriptional regulations of important Forkhead family transcription factors that regulate the aging process. He has shown that Rifampicin analogs can increase life span and delay aging, a finding that has tremendous translation potential. His findings have been published in some of the most respected and leading journals of the field. I believe that Arnab has set up an internationally competitive, collaborative, multidisciplinary program and has several interesting research leads which are bound to generate much excitement in the field. Overall Arnab is showing great potential as a future leader in his chosen area of research and a future fellowship in NASI will help him immensely to foster new collaborations and help him to disseminate his research to a wider and select group of scientific audience.

Proposer: Dr. Sagar Sengupta, Seconder: Dr. Vinay K. Nandicoori


1. Verma S, Jagtap U, Goyala A and Mukhopadhyay A (2018) A novel gene-diet pair modulates C. elegans aging. PLOS Genetics 14(8): e1007608. (if=5.54, ci=1)

2. Tabrez SS, Datta Sharma R, Jain V, Siddiqui AA and Mukhopadhyay A^ (2017) Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity. Nature Communications 8:306 (if=12.53, ci=5)

3. Maity S*, Rajkumar A*, Matai L*, ….Mukhopadhyay A#, Sengupta S#, Chakraborty C# (2016) Oxidative homeostasis regulates response to reductive Endoplasmic Reticulum stress through translation control. Cell Reports 16, 851–865. *,#Equally contribution(if=8.0, ci=15)

4. Singh A, Kumar N, Matai L, Jain V, Garg A and Mukhopadhyay A (2016) A chromatin modifier integrates insulin/IGF-1 signalling and dietary restriction to regulate longevity. Aging Cell 15, pp694–705. (if=7.63, ci=8)

5. Kumar N, Jain V, Singh A, Jagtap U, Verma S and Mukhopadhyay A (2015) Genome-wide endogenous DAF-16/FOXO recruitment dynamics during lowered insulin signalling in C. elegans. Oncotarget 6(39):41418-33. (if=5.168, ci=13)

6. Golegaonkar S, Tabrez SS, Pandit A, Shalini S, Kulkarni MJ and Mukhopadhyay A (2015) Rifampicin reduces Advanced Glycation End products and activates DAF-16 to increase life span in Caenorhabditis elegans. Aging Cell 14(3):463-73. (if=7.63, ci=23)

7. Chamoli M, Singh A, Malik Y, Mukhopadhyay A (2014) A novel kinase regulates Dietary Restriction-mediated longevity in C. elegans. Aging Cell 13(4):641-55. (if=7.63, ci=24)

8. Padmanabhan S, Mukhopadhyay A, Narasimhan S, Tesz G, Czech MP, Tissenbaum HA (2009) A PP2A regulatory subunit, PPTR-1, regulates C. elegans insulin signaling by modulating AKT-1 phosphorylation. Cell 136:939-951.*Co-first authors (if=31.4, ci=152)

9. Oh SW, Mukhopadhyay A, Dixit BL, Raha T, Green MR, Tissenbaum HA (2006) Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation. Nature Genetics 38(2):251-257. Co-first authors (if=27.13, ci=343)

10. Mukhopadhyay A, Vij S, Tyagi AK (2004) Overexpression of a zinc-finger protein gene from rice confers tolerance to cold, dehydration, and salt stress in transgenic tobacco. Proceedings National Academy of Sciences USA 101(16):6309-6314. (if=9.5, ci=440)

318

NALLUR, RAMACHANDRA BASAPPA (b 1958), Professor and Chairman, University of Mysore, Mysuru


Significant contributions in Drosophila Genetics Include: Evolution of new introgressed genetic systems, the short-lived and long-lived Cytoraces in the environs of laboratory with high rate of substitution which would have taken million of years in nature. The rapid divergence of karyotypes, morphology, fitness, mating preference levels and inter sequences simple repeats in these cytoraces is due to the “recombinational speciation” – a maiden report in animal system which illustrates the power of evolution after the event of hybridization under laboratory conditions. Cloning and sequencing of the Sod-1, Rpd3 and aly genes revealed that the novel changes are contributing for the “adaptive genome evolution”. Further, whole genome and transcriptome sequence analysis support 'recombinational speciation’ for rapid genomic changes and ‘adaptive genome evolution' during the 30 year long-range (600-650 generations) interracial hybridization experiment. In Human Genetics the novel findings are: (a) identification of 'advanced maternal grandmother's age' and recombinational errors during meiosis as the potential risk factors for chromosomal aneuploidy leading to Downs syndromes; (b) consanguineous uncle – niece marriages as risk factor for congenital heart diseases (CHD) in South India; (c) Identification of new recombination hotspot- the pseudoautosomal region 3 (PAR3) between the X and Y chromosomes in humans indicating the new dimensions of sex chromosomal dynamics; (d) Identification of SNPs, and CNVs as casual variations in CHD, Asthma, Dyslexia and type 2 diabetes mellitus cases in disease risk genes and (e) Establishment of ‘University of Mysore Genome Centre’ database.

Proposer: Prof. H.A. Ranganath, Seconder: Prof. Mewa Singh


1. Ramachandra, NB and HA Ranganath,1986,The Chromosomes of two Drosophila races: D. nasuta nasuta and D. nasuta albomicana. IV. Hybridization and karyotype repatterning. Chromosoma, 93: 243-248. (if=4.979 , ci=44)

2. Upendra Nongthomba and NB Ramachandra, 1999, A direct screen identifies new flight muscle mutants on the Drosophila second chromosome. Genetics, USA, 71-83. (if=5,963, ci=30)

3. Harini BP and NB Ramachandra, 2003, Evolutionary experimentation through hybridization under laboratory condition in Drosophila: Evidence for Recombinational Speciation. BMC Evolutionary Biology, 3,20 (1-19). (if=3.52, ci=25)

4. Malini S S and NB Ramachandra, 2006, Influence of advanced age of maternal grandmothers on Down syndrome. BMC Medical genetics. 7: 4 (8 pages) Feb. 14th . (if=2.84, ci=82)

5. Smitha R and NB Ramachandra, 2006, Parental consanguinity increases Congenital Heart Diseases in South India. Annals of Hum. Biol. 33(5/6):519-928. (if=1.915, ci=53)

6. Bijanzadeh Mahdi , Mahesh PA, and NB Ramachandra, 2011 An understanding of the genetic basis of Asthma. Review- Indian J. Med Res. 134:149-161 (if=2.031, ci=69)

7. Avinash MV, Marieta S, Prakash P and NB Ramachandra, 2013, Genome-wide copy number scan identifies disruption of PCDH11X in developmental dyslexia. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 9999:1–9. DOI 10.1002/ajmg.b.32199. (if=3.270, ci=35)

8. Avinash M Veerappa, Marita Saldanha, Prakash Padakannaya and NB Ramachandra, 2013, Copy Number Variation analysis in humans reveal previously identified X chromosome Transposed Region (XTR) in Y-chromosome to be a pseudoautosomal region 3 (PAR3). Functional & Integrative Genomics (DOI: 10.1007/s10142-013-0323-6) (if=3.496, ci=27)

9. Jahromi SR, Mahesh PA, Jayaraj BS, Subbarao MV, Holla AD, Sangeetha V, and NB Ramachandra, 2014, Serum Levels of IL-10, IL-17F and IL-33 in Patients with Asthma: A Case-Control Study, Journal of Asthma, 51(10): 1004-1013. (if=1.848, ci=38)

10. Manasa Prabhanjan, Raviraj V. Suresh Megha N. Murthy, NB Ramachandra , 2016, Type 2 diabetes mellitus disease risk genes identified by genome wide copy number variation scan in normal populations. Diabetes Res Clin Pract, http://dx.doi.org/10.1016/j.diabres.2015.12.01 (if=4.1, ci=14)

319

PETER, M.C. SUBHASH (b 1961), Professor and Head, Department of Zoology, Hon. Director, ICEIB, University of Kerala, Kariavattom, Thiruvananthapuram.


For the past two and half decades Dr. Peter has been doing research in stress physiology and endocrinology mainly in the area of thyroid physiology and stress endocrinology in fish. He has successfully presented evidence for a thyroid hormone (TH)–driven sodium pump regulation in fish ionocytes, where TH promotes osmotic competence in varied environments. Extensive work on many fish models provided him with evidences for identifying a role for THs in stress response of fish. He later found an interaction between innate immunity and thyroid-interenal axes in stressed fish. His concept of inter-hormonal interference that explains the interactions of THs with cortisol and adrenaline operates during stress response in fish. He has later conceptualized a novel phenomenon of ease and ease response that provides neuroendocrine basis of stress/ease physiology, which has immense potential in human stress management. His later research on ease physiology provided him evidences to identify the role of melatonin and serotonin as ease hormones in fish. He has established an Inter-University Centre for Evolutionary and Integrative Biology (iCEIB) in 2013 and a Department of Integrative Biology in the University of Kerala in 2019 that offers M.Sc and M.Phil courses and Ph.D. programme in Integrative Biology with a grant of 8 crore directly from the Government of Kerala. As a science manager who serves as Associate Editor of Elsevier journal General and Comparative Endocrinology, he organizes many International Conferences and Workshops in Integrative Stress Physiology and Endocrinology.

Proposer: Prof. Atanu Kumar Pati, Seconder: Prof. Edathil Vijayan


1. Peter, M.C.S., Simi. S., (2017). Hypoxia stress modifies Na+/K+-ATPase, H+/K+-ATPase, Na+/NH4+-ATPase and nkaα1 isoform expression in the brain of immune-challenged air-breathing fish. J. Exp. N. Sci. 11, 1-18. (if=1.30, ci=8)

2. Simi,S., Peter, V. S., Peter, M. C. S., (2017). Zymosan-induced immune challenge modifies the stress response of hypoxic air-breathing fish (Anabas testudineus Bloch): Evidence for reversed patterns of cortisol and thyroid hormone interaction, differential ion transporter functions and non-specific immune response. Gen. Comp. Endocrinol. 251, 94 (if=2.86, ci=10)

3. M.C.S. Peter (2013). Understanding the adaptive response in vertebrates: The phenomenon of ease and ease response during post-stress acclimation Gen. Comp. Endocrinol. 181, 59-64. (if=2.86, ci=8)

4. Peter M. C. S. (2011). “INVITED REVIEW”. The role of thyroid hormones in stress response of fish. Gen. Comp. Endocrinol. 172, 198-210 (if=2.86, ci=14)

5. Peter M. C. S. and Rejitha V. (2011). Interactive effects of ambient acidity and salinity on thyroid function during acid and post-acidic acclimation of air-breathing fish Gen. Comp. Endocrinol. 174, 175-183 (if=2.56, ci=8)

6. Peter M. C. S., J. Leji., V.S. Peter (2011). Ambient salinity modifies the action of triiodothyronine in the air-breathing fish, Anabas testudineus Bloch: Effects on mitochondria-rich cell distribution, osmotic and metabolic regulations. Gen. Comp. Endocrinol. 171, 225-231 (if=2.86, ci=15)

7. Peter V. S. and Peter M. C. S. (2011). “INVITED REVIEW” The interruption of thyroid and interregnal and the inter-hormonal interfrerence in fish: Does it promote physiologic adaptation or maladaptation Gen. Comp. Endocrinol. 174, 249-258. (if=2.86, ci=11)

8. George, N., V.S. Peter, M.C.S Peter. (2013) Physiologic implications of inter-hormonal interference in fish: Lessons from the interaction of adrenaline with cortisol and thyroid hormones in climbing perch (Anabas testudineus). Gen. Comp. Endocrinol 181, 122-129. (if=2.86, ci=9)

9. Ings, J. S., George, N., Peter, M. C. S., Servos, M. R. and Vijayan, M. M. (2012). Venlafaxine and atenolol disrupt epinephrine-stimulated glucose production in rainbow trout hepatocytes. Aquatic Toxicol, 106, 48–55. (if=3.88, ci=14)

10. Babitha, G. S. and Peter, M.C.S. (2010). Cortisol promotes and integrates the osmotic competence of the organs in North African Catfish (Clarias gariepinus Burchell): Evidence from in vivo and in situ approaches. Gen. Comp. Endocrinol. 168, 14-21. (if=2.86, ci=25)

320

RAMESH, SARAF RAJAGOPALAIAHSETTY (b 1954), CEO and Academic Advisor, Mahajana First Grade College (Autonomous), Jayalakshmipuram, Mysuru – 570 012


Dr.Ramesh chose Drosophila nasuta subgroup as research model. He studied intraspecific/interspecific chromosomal variations, biochemical genetics of adult isoenzymes, male accessory gland secretions and larval salivary gland secretions to understand genetic differentiation. He established: • X-chromosomes are homosequential, while chromosomes 2 and 3 differ by inversions and transpositions • Correlation between isoenzyme variation and taxonomic relationship • Absence of correlation between size or number of cells in salivary gland and increased secretion • Pattern polymorphism of larval salivary and adult male accessory gland secretions and chromosomal linkage He studied fitness, eye pigments, sexual selection, localization of mutations and sperm precedence in D.nasuta and D.n.albomicans, their mutants and established • Fitness superiority and sexual selection of certain mutants over wild-type • Location of seven mutant genes on chromosome 2 and one on chromosome 3 • Last mated male sperm precedence in doubly mated females is not ubiquitous Working on learning and memory in Drosophila, validating influence of phytochemicals on radiation induced damages, biochemical and genetic system of wild-type, transgenic Alzheimer’s (AD) and Parkinson disease (PD) models of D.melanogaster, he established • Olfactory memory status in wild-type flies • Age-associated changes in neurotransmitter modulators and structural changes in olfactory learning neural system • Learning and memory in AD model • Amelioration of phytochemicals on memory impairment and loss • Role and extent of neurotoxicity in PD development • Neuroprotection and circadian rhythmicity in transgenics • Phosphorylation prevention and aggregation of α-synuclein in PD model • Radioprotection of phytochemicals against gamma radiation toxicity

Proposer: Prof. H. A. Ranganath, Seconder: Prof. Mewa Singh


1. Ramesh, S. R. and Kalisch, W. -E. 1988 "Glue proteins in Drosophila nasuta". Biochem. Genet. 26: 527-541 (ci=17)

2. Ramesh, S. R and Shivanna, N. 1999 “SDS-PAGE pattern polymorphism of Xchromosomal glue proteins in the natural populations of two Drosophila nasuta subgroup species”. Biochem. Genet. 37: 1-22 (if=0.797, ci=9)

3. Ravi Ram, K and Ramesh, S. R. 2001. “Male accessory gland secretory proteins in a few members of the Drosophila nasuta subgroup”. Biochem. Genet. 39: 99-115. (if=0.625, ci=14)

4. Hosamani, R., Ramesh, S. R and Muralidhara, M. 2010. “Attenuation of Rotenone- Induced Mitochondrial Oxidative Damage and Neurotoxicty in Drosophila melanogaster Supplemented with Creatine”. Neurochem. Res. 35: 1402-1412 (if=2.608, ci=50)

5. Shruti, B and Ramesh, S. R. 2013 “Last mated male sperm precedence in doubly mated females is not ubiquitous: evidence from sperm competition in the laboratory populations of Drosophila nasuta nasuta and Drosophila nasuta albomicans”. J. Genet. 92: 3(if=1.013, ci=2)

6. Haddadi, M., Jahromi, S. R., Shivanandappa, T and Ramesh, S. R. 2013. "Decalepis hamiltonii root extract attenuates the age-related decline in the cognitive function in Drosophila melanogaster". Behavioural Brain Res. 249: 8-14 (if=3.298, ci=10)

7. Haddadi, M., Jahromi, S. R., Sagar, B. K. C., Patil, R. K., Shivanandappa, T and Ramesh, S.R. 2014. "Brain Aging, Memory Impairment and Oxidative Stress: A study in Drosophila melanogaster". Behavioural Brain Research 259: 60-69 (if=3.298, ci=43)

8. Jahromi, S. R., Haddadi, M., Shivanandappa, T and Ramesh, S.R. 2015.“Modulatory effect of Decalepis hamiltonii on ethanol-induced toxicity in transgenic Drosophila melanogaster model of Parkinson’s disease”. Neurochem. International 80: 1-6 (if=3.092, ci=7)

9. Jahromi, S. R., Haddadi, M., Shivanandappa, T and Ramesh, S.R. 2015. “Attenuation of Neuromotor Deficits by Natural Antioxidants of Decalepis hamiltonii in Transgenic Drosophila Model of Parkinson's Disease”. Neuroscience. 293: 136-150 (if=3.357, ci=26)

10. Haddadi, M., Nongthomba, U., Jahromi, S. R and Ramesh, S. R. 2016. “Transgenic Drosophila model to study apolipoprotein E4-induced neurodegeneration. Behavioural Brain Res. 301: 10-18 (if=3.028, ci=4)

321

ROY, BISHNUPADA (b 2060), Professor, North-Eastern Hill University, Shillong


I am personally acquainted with the scientific work of Prof. Bishnupada Roy who has more than 33 years of research experience in the field of parasitology involving taxonomy and chemotherapy of helminth parasites. He has described surface topography of more than 30 different species of helminth parasites and has showed that micro-topography of helminth parasites is species specific, thus provided an additional set of criteria of taxonomic value. Prof. Roy contributed extensively in the field of molecular diagnosis by developing species specific primers and DNA barcodes for several food borne zoonotic helminths and also described 3 new species of helminth parasites. Prof. Roy has developed a new technique for processing of soft biological tissues for scanning electron microscopy. The method is in use globally in many SEM Labs because of its significant features - it is simple, rapid and economical. He also established anthelmintic potential of several medicinal plants consumed by different tribes in North-East India to cure intestinal helminth infections. At present his group is trying to unveil the mechanism of action of the isolated active compounds of these plants and also to evaluate their toxic effect, if any, on the consumers in Northeast India. Eleven students have been awarded Ph.D.degree under his supervision and 7 more are working for their degree.

Proposer: Prof. Anupam Chatterjee, Seconder: Prof. Nirmalendu Saha


1. Tandon, V., Pal, P., Roy, B., Rao, H.S.P. & Reddy, K.S. (1997): In vitro anthelmntic activity of root tuber extract of Flemingia vestita, an indigenous plant in Shillong, India. Parasitology Research, 83: 492-498. (if=2.558, ci=79)

2. Dey, S., Basubaul, T. S., Roy, B & Dey, D. (1989) : A new rapid method of air drying using Tetramethylsilane for scanning electron microscopy”. Journal of Microscopy, 156 : 269-261. (if=2.19, ci=97)

3. Roy, B. & Tandon, V. (1996) : Effect of root tuber extract of Flemingia vestita, a leguminous plant, on Artyfechinostomum sufrartyfex and Fasciolopsis buski : a scanning electron microscopy study. Parasitology Research, 82 : 248-252. (if=2.558, ci=79)

4. Challam, M., Roy, B. & Tandon, V. (2010): Effect of Lysimachia ramosa (Primulaceae) on helminth parasites: Motility, mortality and scanning electron microscopic observations on surface topography. Veterinary Parasitology, 214: 214-218. (if=2.545, ci=105)

5. Roy, B. & Tandon, V. (1992) : Seasonal prevalence of some zoonotic infections in cattle and pigs in a humid sub-tropical montane zone in India. Veterinary Parasitology, 41 : 69-76 (if=2.545, ci=105)

6. Dasgupta, S., Roy, B. & Tandon, V. (2010): Ultrastructural alterations of the tegument of Raillietina echinobothrida treated with the stem bark of Acacia oxyphylla (Leguminosae). Journal of Ethnopharmacology. 172(2): 568-571. (if=3.115, ci=162)

7. Giri, B. R. & Roy, B. (2014). Resveratrol induced structural and biochemical alterations in the tegument of Raillietina echinobothrida. Parasitology International, 63: 432-437. (if=2.111, ci=51)

8. Roy, B., K. Lalchhandama & Dutta, B. K. (2008): Scanning electron microscopic observations on thein vitro anthelmintic effects of Millettia pachycarpa on Raillietina echinobothrida. Pharmacognosy Magazine, 4: 20-25. (if=1.525, ci=27)

9. Roy, B., Dasgupta, S. & Tandon, V. (2009): Ultrastructural observations on Fasciolopsis buski and its alterations caused by shoot extract of Alpinia nigra. Microscopy Research and Technique. 72(2): 61-66. (if=1.17, ci=107)

10. Sharma, S. Lyngdoh, D., Roy, B. & Tandon, V. (2016). Molecular Phylogeny of Cyclophyllidea (Cestoda:Eucestoda): An in-silico analysis based on mtCOI gene. Parasitology Research. DOI 10.1007/s00436-016-5092-4. (if=2.558, ci=79)

322

SINHA, RAVINDRA KUMAR (b 1954), Professor and Head, Department of Zoology, Patna University, Patna


The nominee saved the Ganges dolphin from extinction in India. The fishermen used to kill the dolphins to extract body oil as fish attractant. He discovered an alternative to the dolphin oil from fish scraps which led to significant reduction in the dolphin poaching (Sinha, 2002). He conducted continuous surveys using country boats in the entire length of the Ganges and most of its tributaries in India and Nepal to assess the distribution range, population status, ecological requirements and threats to the dolphin (Smith et al. 1994; Sinha 1997; Sinha et al, 2000; Sinha 2000, Sinha and Sharma 2003; Sinha and Kannan 2014). Based on the analyses of mitochondrial cytochrome b and nuclear interphotoreceptor retinoid-binding protein (IRBP) gene sequence of the 15 Ganges dolphins, and its closer molecular relationship with the baleen whales, he regarded the species as a “living fossil” (Verma et al.,2004). His research and conservation efforts, attracted the attention of both national and international policy makers, executives and scientific communities. In a positive response, Government of India designated the dolphin as National Aquatic Animal in 2009. He developed a Conservation Action Plan for the Ganges dolphin in 2010 (Sinha et al. 2010), which was enthusiastically accepted by the Government of India. The nominee has been conferred “Padma Shri” in 2016, the Swarna Jayanti Puruskar of the National Academy of Sciences, India in 2000, and the Order of the Golden Ark by His Royal Highness Prince Bernhard of the Netherlands in 1999.

Proposer: Prof. Madhav D. Gadgil, Seconder: Prof. Pradeep Das


1. Kannan, K., Tanabe, S., and Tatsukawa, R. and Sinha R.K.(1994): Biodegradation capacity and residue pattern of organochlorines in Ganges river dolphins from India. Toxicological and Environmental Chemistry, 42. 249-261 (if=2.309, ci=72).

2. Sinha R.K.(1997): Status and Conservation of Ganges river dolphin in Bhagirathi-Hooghly river systems in India. Int. J. Ecol. and Env. Sc. 23 : 343-355. (if=1.2, ci=26).

3. Senthilkumar, K., Kannan, K., Sinha, R.K., Tanabe, S., and Giesy, J.P.(1999): Bioaccu Profiles of Polychlorinated Biphenyl Congen and Organochl Pesticides in Ganges River Dolphins. Environ Toxicol and Chem, 18. ( 7). 1511-1520 (if=2.309, ci=94).

4. Sinha, R. K. et al. (2000): Status and distribution of the Ganges susu in the Ganges R Syst of India and Nepal. In ``Biol and Conserv of Freshwater Cetaceans in Asia,'' eds R.R. Reeves, B.D. Smith, and T. Kasuya. Occas papers, IUCN SSC 23: 54-61 (if=0.0, ci=29).

5. Sinha, R. K., (2002): An alternative to dolphin oil as a fish attractant in the Ganges River system: Conservation of the Ganges River dolphin. Biological Conservation, Vol.107(2): 253-257 (if=3.566, ci=22).

6. Verma, S. K., Sinha, R. K., and Singh, Lalji. (2004) Phylogenetic position of Platanista gangetica: insights from the mitochon cyt b and nuclear interphotoreceptor retinoid-binding protein gene sequences. Mole Phylo and Evol. 33; 280-288 (if=4.018, ci=17).

7. Yeung, L. W. Y., Yamashita, N., Taniyasu, S., Lam, P. K. S., Sinha, R.K., Borole, D.V., and Kannan, K. (2009): A survey of PFCs in surface water and biota including dolphins from the Ganges River and in other water bodies in India. Chemo, 76(1):55-62 (if=3.054, ci=92).

8. Kannan, K., Praamsma, M. L., Oldi, J. F., Kunisue, T. and Sinha, R. K .(2009): Occurrence of perchlorate in drinking water, ground water, surface water and human saliva from India. Chemosphere, Vol. 76 (1): 22-26 (if=3.054, ci=100).

9. Pozo, K., Harner, T., Lee, S. C., Sinha, R. K., Sengupta, B., Loewen, M., Geethalakshmi, V., Kannan, K. and Volpi, V. 2011. Assessing Seasonal and Spatial Trends of Pers Organ Pollut (POPs) in Indi Agri Reg using PUF Disk PAS. Env Pollut 159, 646-53 (if=3.135, ci=75).

10. Sinha, R. K. and Kannan, K. (2014): Ganges River dolphin: An overview of Biology, Ecology, and Conservation status in India. AMBIO, 43:1029-1046 (if=2.973, ci=3).

323

YENUGU, SURESH (b 1972), Associate Professor, School of Life Sciences, Department of Animal Biology, University of Hyderabad, Hyderabad


The nominee, Suresh Yenugu is an established investigator in the field of Reproductive Immunology. His laboratory has demonstrated that the antimicrobial peptides of the male reproductive tract exhibit synergistic bacterial killing when used in combination with commonly used antibiotics, thus paving the way for developing strategies to reduce the use of antibiotics to treat infections. His in depth studies on the role of antimicrobial genes in the innate immunity of the male reproductive tract under conditions that mimic an infection established an unconventional function for reproductive tract genes beyond sperm function. The epigenetic mechanisms of antimicrobial regulation demonstrated in his studies opened up the possibility of use of molecules that regulate epigenetic changes to potentiate innate immunity. His studies are of clinical importance which will lead to the use of epigenetic modulators alone or in combination with reproductive tract antimicrobial proteins to boost immune response against reproductive tract infections. His research contributions also led to the identification of many male reproductive tract proteins as potential immuno-contraception targets. His studies showed that knocking down testis specific genes affect sperm function and fertility and this is one of his outstanding contributions in the recent days.

Proposer: Prof. Kambadur Muralidhar, Seconder: Prof. Aparna Dutta Gupta


1. Rajesh A and Yenugu S. shRNA mediated ablation of Prostate and Testis Expressed (Pate) messenger RNA and protein results in impaired sperm function and fertility. Andrology (in press) (if=2.5)

2. Narmadha G and Yenugu S. (2016): Immunization against lysozyme-like proteins affect sperm function and fertility in the rat. Journal of Reproductive Immunology. 118:100-108. (if=3.2)

3. Narmadha G and Yenugu S. (2016): In silico and Biochemical Characterization of Lysozyme-like proteins in the rat. PLoS ONE 11(9):e0161909. (if=4.4, ci=0.5)

4. Rajesh A and Yenugu S. (2015): Effect of immunization against prostate and testis-expressed (PATE) proteins on sperm function and fecundity. Journal of Reproductive Immunology. 110:117-129. (if=3.2, ci=1.0)

5. Biswas B, Bhushan S, Rajesh A, Suraj SK, Lu Y, Meinhardt A, Yenugu S. (2015): Uropathogenic Escherichia coli (UPEC) induced antimicrobial gene expression in the male reproductive tract: evaluation of the potential of Defensin 21 to limit infection. An (if=2.5, ci=0.67)

6. Rajesh A, Yenugu S. (2012): Genomic organization, tissue distribution and functional characterization of the rat pate gene cluster. PLoS One. 2012; 7(3):e32633 (if=4.4, ci=1,33)

7. Narmadha G, Muneswararao K, Rajesh A, Yenugu S. (2011): Characterization of a novel lysozyme-like 4 gene in the rat. PLoS One. 6(11):627659 (if=4.4, ci=1.29)

8. Yenugu S, Hamil KG, Radhakrishnan Y, French FS, Hall SH. The androgen regulated epididymis sperm-binding protein, ESC42, is an antimicrobial beta-defensin. Endocrinology. 2004; 145(7): 3165-3173. (if=4.5, ci=5.71)

9. Yenugu S, Richardson RT, Sivashanmugam P, Wang Z, O’Rand MG, French FS, Hall SH. Antimicrobial activity of Eppin, an androgen regulated sperm bound protein with a whey acidic protein motif. Biology of Reproduction 2004; 71(5): 1484-90. (if=3.8, ci=4.86)

10. Yenugu S, Hamil KG, Birse C.E, Ruben S.M, French F.S, Hall S.H. Antibacterial properties of the sperm-binding proteins and peptides of human epididymis 2 (HE2) family; salt sensitivity, structural dependence and their interaction with outer and cytop (if=4.4, ci=4.2)

324

AGRAWAL, NIRUPAMA (b 1954), Professor, Department of Zoology, University of Lucknow, Lucknow


Prof. Agrawal has original contributions in Helminth taxonomy like monogenoideans, digeneans, cestodes and nematodes. She has solved taxonomic problems and established new species, using morphometric analyses (78, 82,83,128) and new genera from marine fishes of Indian east coast (105, 124). Investigations from collections of Great Barrier Reef (91, 92) and South America (99) resulted in description of four new species. Some Indian species were wrongly placed under genera Ancyrocephalus Creplin, 1839 Haliotrema Johnston et Tiegs, 1922 or Urocleidus Mueller, 1934. New genera were established to accommodate dactylogyrids, infecting various fishes. They are Sclerocleidoides Agrawal et al., 2001 (105) (to include Ancyrocephalus etropli Gussev, 1963); Mastacembelocleidus (118) (Ancyrocephalus bam Tripathi, 1959, Urocleidus rhynchobdelli Jain, 1959, Urocleidus heteronchorus Kulkarni, 1969, Haliotrema tandoni Agrawal and Singh, 1982 and Urocleidus raipurensis Dubey et al., 1992); Chandacleidus Agrawal et al., 2006 (125) (Urocleidus recurvatus Jain, 1961), Xenentocleidus (126) (Urocledius xenentodoni Jain, 1961) and Sundanonchus (130) (Urocleidus behuri Agrawal et Singh, 1982). Further a new genus Esmocleidus (Ancyrocephalus esomi Gusev, 1963 and A. chakrabarti Gusev, 1976) was proposed (171) to accommodate three species from Esomus. Their phylogenetic position is established using molecular markers. Invasive potential of monogenoids via fish trade is reported (127, 131, 162, 163). Recently, DNA extraction, PCR, electrophoresis and different bioinformatic tools are used to complement the morphometric analyses and evolutionary aspects for monogenoidean and digenean parasites (165, 169, 175). Rhythmicity of digeneans were studied (166, 167,168). She has also contributed monographs on Monogenoidea and Trematode Metacercaria.

Proposer: Prof. R.C. Sobti, Seconder: Prof. Omkar


1. Choudhary K., Ray, S., Pandey, K.C. and Agrawal N. 2019.. Morphological and molecular characterization of six Indian Tetracotyle type metacercariae (Digenea: Strigeidae Railliet, 1919), using ribosomal and mitochondrial DNA. Parasitology Internat (if= 2.0)

2. Choudhary K., Tripathi, A., Pandey, K.C. and Agrawal N. 2017. Morpholpgical and molecular characterization of three Indian Neascus type metacercariae (Digenea:Diplostomidae). Parasitology International., 66, 652–659. (if=2.0)

3. Agrawal N, Rajvanshi S and Asthana A. 2017. Intraguild interaction among fiveoioxenous congeneric Thaparocleidus sp. (Monogenoidea) infecting freshwater shark Wallago attu Bloch and Schneider, 1801. Journal of Helminthology. 91, 718-725 (if=1.4, ci=1)

4. Rajvanshi S, Choudhary K and Agrawal, N. 2016. Threading: A novel in silico indagation method for genetic characterization of some diplostomoid metacercariae (Digenea:Diplostomidae Poirier, 1886). Experimental Parasitology.171:71-76. (if=1.86, ci=1)

5. A Tripathi, S Rajvanshi, and N Agrawal. 2014. Monogenoidea on exotic Indian freshwater fishes. 2. Range expansion of Thaparocleidus caecus and T. siamensis (Dactylogyridae) by introduction of striped catfish Pangasianodon hypophthalmus (Pangasiida(if=0.6, ci=5)

6. Tripathi A, Agrawal N, and Pandey, KC. 2007. The status of Quadriacanthus Paperna, 1961 and Anacornatus Dubey et al., 1991 (Monogenoidea :Dactylogyridae) with redescription of Q. kobiensis Ha Ky, 1968, new geographical records for Q. bagrae Pape (if=2, ci=5)

7. A Timbao, Kritsky DC, Yuan S, Jianying Z, and Shuhua S, and Agrawal, N. 2006 Diplectanids infesting the gills of the barramundi Lates calcarifer (Bloch) (Perciformes: Centropomidae), with the proposal of Laticola n.g. (Monogenoidea: Diplecta (if=1.316, ci=23)

8. DC Kritsky, KC Pandey, N Agrawal and SMA Abdullah. 2004. Monogenoids from the gills of spiny eels (Teleostei: Mastacembelidae) in India and Iraq, proposal of Mastacembelocleidus gen. n., and status of the Indian species of Actinocleidus, Urocleid (if=1.5, ci=38)

9. Agrawal, N and Kritsky, DC. 1998. Neotropical Monogenoidea. 33. Three new species of Ancistrohaptor n.g. (Dactylogyridae, Ancyrocephalinae) on Triportheus spp. (Teleostei, Characidae) from Brazil, with checklists of ancyrocephalines recorded fro (if=1.316, ci=13)

10. Agrawal N. Chisholm LA and Whittington ID. 1996. Pseudohexabothrium taeniurae n.sp. (Monogenea: Hexabothridae from the gills of Taeniura lymna (Dasyatidae) off Heron Island, Great Barrier Reef, Australia. J. Parasitol. 82: 131-136. (if=1.3, ci=5)

325

DAS, MANOJ KUMAR (b 1957), Scientist E, National Institute of Malaria Research (ICMR), Ranchi


Dr. M K Das is a trained biomedical scientist in the field of vector borne diseases. He has worked in the remote tribal areas for almost 16 years (Car Nicobar, Andaman & Nicobar Islands) of the country. He was working as the Officer-in-charge MRC Field Station Car Nicobar Island from the year 1990 to 2006. He was deputed to Car Nicobar with a big challenge to control endemic malaria. I am most delighted to feel proud that Dr. Das single handedly planned executed the bioenvironmental malaria control in Car Nicobar and brought down malaria to very low level under the guidance of Late Dr. V P Sharma. This he could do without the use of any insecticide. One of his contributions is the finding of Plasmodium knowlesi from Andaman Nicobar Islands. He is working in the Ranchi, Field Unit of NIMR for the last ten years. He has carried out work on transmission dynamics of malaria, insecticide resistance on malaria vectors, mapping of filariasis in Jharkhand state. His research on Durable Lining, Long Lasting Insecticide Nets (LLINs) leads to the development of novel vector control tools. His studies will help for the elimination of filariasis and malaria from the state vis-à-vis from the country. He has published more than 76 scientific papers in high impact journals. He was awarded ICMR awards for Biomedical research conducted in underdeveloped areas in 2006. He was awarded with the honour of Lt. Governor’s Commendation Certificate at A & N Islands 2015 and also Dr. M.O.T. Iyengar Memorial Award 2015 (ICMR, New Delhi).

Proposer: Prof. A. P. Dash, Seconder: Prof. Y. D. Sharma


1. Das, M.K., Joshi Hema, Verma A, Singh S S and Adak T (2005): Malaria among Jarawas -the primitive and isolated tribe of Andaman and Nicobar Islands, India Annals Trop Med and parasitol.99(6): 1-8 (if=1.20, ci=8)

2. Das M K, S S Singh, T Adak, K Vasantha and D Mohanty (2005): The Duffy blood group of Jarwas – the primitive and vanishing tribe of Andaman and Nicobar Islands, India. Transf. Med. (15): 237-240 (if=1.68, ci=5)

3. Ahmed A., Das, M.K. Vas Dev, M.A. Saifi, Wajihullah and Y.D. Sharma (2006): Quadruple Mutations in Dihydrofolate Reductase of Plasmodium falciparum Isolates from Car Nicobar Island, India. Antimicrob Agents and Chemother. 50: 1546-1549 (if=4.47, ci=25)

4. Ahmed A, Das M K, Dev V, Wajihullah and Sharma YD (2007): Prevalence of Mutations Associated with Higher Levels of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum isolates from Car Nicobar Island and Assam, India. Antimicrob Agents C (if=4.47, ci=28)

5. Lumb V, Das M.K., Mittra P, Ahmed A, Singh SS, Kaur P, Kumar M, Dash AP and Sharma YD (2009): Emergence of an Unusual Sulfadoxine-Pyrimethamine Resistance Pattern and a Novel K540N Mutation in Dihydropteroate Synthetase among Post-tsunami Plasmodi (if=5.99, ci=25)

6. Lumb V, Das M.K., Singh N, Dev V, Khan W, Sharma YD, (2009): Charactristic of genetic hitchhiking around Plasmodium falciparum dihydrofolate reductase (dhfr) gene associated with pyrimethamine resistance, in India. Antimicrob Agents Chemother; 53( (if=4.47, ci=14)

7. Das M.K, Lumb V , Mittra P. , Singh S.S. , Das A.P. and Sharma Y.D.(2010): High Chloroquine treatment failure rates and predominance of mutant genotypes associated with chloroquine and antifolate resistance among falciparum malaria patients from (if=5.31, ci=17)

8. Singh O.P., Dykes C.L., Das M.K., Pradhan S., Bhatt R.N., Agarwal O.P. and Adak T.(2010): Presence of two alternative kdr-like mutations, L1014F and novel mutation , V1010L, in the voltage Na+channel of Anopheles culicifacies from Orissa India. Mal (if=3.11, ci=33)

9. Das M K, Dhamodharan R, Hoti SL, Das AP (2011): Molecular differentiation of periodic and sub-periodic Wuchereria bancrofti and Brugia malayi by randomly amplified polymorphic DNA (RAPD) markers. World journal Microbiol Biotechnol;1525-30. (if=1.53, ci=1)

10. Tyagi R K, Das M K*, Singh S S, Sharma Y D, (2013): “Discordance in drug resistance associated mutation patterns in marker genes of Plasmodium falciparum and Plasmodium knowlesi during co-infections” J Antimicrob Chemother ; 68 (5):1081-8. *equal (if=5.31, ci=29)

326

HUSSAIN, SYED AINUAL (b 1960), Scientist G, Wildlife Institute of India, Dehradun


Dr. Syed Ainul Hussain is internationally acclaimed for his contributions to wildlife sciences. His cutting edge research on otters has led to enhanced understanding of their status, ecology and sociobiology. His work on reproductive success and population vulnerability of gharial has contributed to the understanding of the ecology and biology of this ‘Critically Endangered’ species. His pioneer work on environmental flow contributed significantly in decision making at apex level on water allocation for conservation. His work on seals and penguins in Antarctica provides the baseline for further research. His research on the last remaining population of the critically endangered Eld’s deer or Sangai is unmatched. Dr. Hussain’s research on the movement of breeding waterbirds with special reference to Black-necked cranes and Bar-headed geese has unfolded the mystery of movement pattern of migratory water birds and their ecology in the Tibetan plateau in the wake of increasing anthropogenic pressures and climate change. His scientific contributions to ecosystem level processes such as biomass productivity of wetlands and ecosystem services of the mangrove ecosystems and forested landscapes are highly appreciated. His work on endangered species, ecosystems and their link to biodiversity conservation has helped bridge the gap between ecology and conservation biology.

Proposer: Prof. Mewa Singh, Seconder: Prof. K.S. Rangappa


1. Kumar, A, Ghazi, M.G.U, Hussain, S.A., Bhatt D., Gupta, S.K. (2016): Mitochondrial and nuclear DNA based genetic assessment indicated distinct variation and low genetic exchange among the three subspecies of Swamp deer. Evolutionary Biology,44:31-42. (if=2.747)

2. Platt, R.P., Ogra. M.V., Badola, R., Hussain, S.A. (2016): Conservation-induced resettlement as a driver of land cover change in India: An object-based trend analysis. Applied Geography. 69 (2016) 75e86 (if=2.565)

3. Tuboi, C., Hussain, S.A. (2014): Factors affecting forage selection by the endangered Eld’s deer and hog deer in the floating meadows of Barak-Chindwin Basin of North-east India. Mammalian Biology. 81(1):53-60. (if=1.595)

4. Hoffmann, M., Hilton-Taylor, C., Angulo, A.,Hussain, S. A.,et al. (2010): The Impact of Conservation on the Status of the World’s Vertebrates. Science. 330: 1503-1509. (if=34.661, ci=688)

5. Hussain, S.A. (2009): Basking site and water depth selection by gharial (Gavialis gangeticus) in National Chambal Sanctuary and its implication for river conservation. Aquatic Conservation. 19(2): 127-133. (if=34.661, ci=845)

6. Schipper, J., Chanson, J. S., Chiozza, F., Hussain, S. A.,et al. (2008): The Status of the World's Land and Marine Mammals: Diversity, Threat, and Knowledge. Science, 322: 225-230. (if=2.415, ci=24)

7. Anoop, K. R., Hussain, S.A. (2004): Factor affecting habitat selection by smooth coated otter Lutra perspicillata in Kerala, India. Journal of Zoology. 263 (4) 417-423. (if=1.819, ci=43)

8. Hussain, S.A. (1999): Reproductive success, hatchling survival and growth of a managed population of Ganges gharial. Biological Conservation. 87:261-268. (if=3.985, ci=36)

9. Hussain, S.A., Choudhury, B.C. (1997): Status and distribution of smooth-coated otter (Lutra perspicillata) in National Chambal Sanctuary. Biological Conservation. 80:199-206. (if=3.985, ci=40)

10. Hussain, S.A. (1996): Group size, group structure and breeding in smooth-coated otter (Lutra perspicillata), Geoffroy in National Chambal Sanctuary. Mammalia. 60(2): 289-297. (if=0.681, ci=19)

327

MISRA, ADITYA KUMAR (b 1957), Vice Chancellor, Maharashtra Animal and Fishery Sciences University, Futala Lake Road, Nagpur


Prof. Misra’s pioneering research works on embryo biotechnology in buffalo lead to establishment of embryo transfer (ET) technology in this species that is so important for India and Asia. Consequently, he was invited and sponsored as lead speaker in several national/ international conferences in India and many other top buffalo rearing countries [Italy 2X, Brazil, China, Indonesia, Sri Lanka, Philippines etc.] and became global leader in this field. He produced first buffalo calves following freezing of embryos & non-surgical and surgical embryo transfers in Asia. His group demonstrated first successful vitrification of immature buffalo oocytes; and produced over thousand cattle and over 140 buffalo calves using ET Technology, including a record 11 calves following embryo transfer to 14 recipients (78.6% conception) that was widely acclaimed by media and the Prime Minister. He established OPU-IVF technology in buffalo and Sahiwal cows and was involved in production of first buffalo calf through OPU-IVF in India. The first ONBS project of India/Asia was also successfully implemented by his group at NDDB. He was actively involved in the superovulation of more than 3500 indigenous (Sahiwal, Gir, Kankrej, Red-Sindhi), crossbred and exotic (Holstein and Jersey) cows. Produced over 9700 viable embryos, cryopreserved over 5400 embryos and established over 1400 pregnancies using ET technology. For his outstanding research contribution he has been bestowed with three national awards viz. Rafi Ahmad Kidwai Award and Jawaharlal Nehru Award by the ICAR and Dr. P. Bhattacharya Memorial Award by the National Academy of Agricultural Sciences.

Proposer: Dr. G. C. Mishra, Seconder: Dr. Mohan Wani


1. Mishra, V., Misra, A.K. and Sharma, R (2008): A comparative study of parthenogenic activation and in vitro fertilization of bubaline oocytes, Anim. Reprod. Sci.103:249-259. (if=1.377, ci=16)

2. Shukla, MK and Misra, AK. (2007): Effect of bradykinin on Murrah buffalo (Bubalus bubalis) semen cryopreservation. Anim. Reprod. Sci. 97:175-179. (if=1.377, ci=92)

3. Mishra, V., Misra, A.K. and Sharma, R. (2007): Effect of ambient temperature on in-vitro fertilization of Bubaline oocyte. Anim. Reprod. Sci. 100:379-384. (if=1.377, ci=72)

4. Wani, N.A., Misra, A.K., Maurya, SN (2004): Maturation rates of vitrified-thawed immature buffalo (Bubalus bubalis) oocytes: effect of different types of cryoprotectants. Anim. Reprod. Sci. 84 : 327–335. (if=1.377, ci=63)

5. Wani, N.A., Maurya, S.N., Misra, A.K., Saxena, V.B. and Lakhchaura, B.D. (2004): Effect of cryoprotectants and their concentration on in vitro development of vitrified-warmed immature oocytes in (if=1.377, ci=63)

6. Pant, H.C., Sharma, R.K., Patel,S.H., Shukla, H.R., Mittal, A.K., Kasiraj, R., Misra, A.K., Prabhakar, J.H. (2003): Testicular development and its relationship to semen production in Murrah buffalo bulls. Theriogenology 60: 27-34. (if=2.056, ci=50)

7. Misra, A.K., Mutha Rao, M., Kasiraj, R., Ranga Reddy, N.S. and Pant, H.C. (1999): Factors affecting pregnancy rate following non-surgical embryo transfer in buffalo (Bubalus bubalis) - a retrospective study. Theriogenology, 52 (1): 1-10. (if=2.056, ci=22)

8. Misra, A.K., Kasiraj, R., Mutha Rao, M., Rangareddy, N.S., Jaiswal, R.S. and Pant, H.C. (1998): Rate of transport and development of preimplantation embryo in the superovulated buffalo (Bubalus bubalis). Theriogenology, 50(4):637-649. (if=2.056, ci=25)

9. Kasiraj, R., Misra, A.K., Mutha Rao, M., Jaiswal, R.S. and Rangareddi, N.S.(1993): Successful Culmination of Pregnancy and Live Birth Following the Transfer of Frozen-Thawed Buffalo Embryos. Theriogenology, 39: 1187 - 1192. (if=2.056, ci=18)

10. Misra, A.K., Joshi, B.V., Agrawala, P.L., Kasiraj, R., Sivaiah, S., Rangareddi, N.S. and Siddiqui, M.U. (1990): Multiple ovulation and embryo transfer in Indian buffalo (Bubalus bubalis). Theriogenology, 33(5):1131-1142. (if=2.056, ci=43).

328

RAISUDDIN, SHEIKH (b 1961), Professor, Department of Medical Elementology & Toxicology, Jamia Hamdard, New Delhi


Prof. S. Raisuddin has significantly contributed to the field of toxicology by taking lead in newer areas of research and mentoring over 30 Ph.D. scholars. He has made significant contributions to three major areas of toxicology: biomarkers of exposure and effects and their utility in monitoring and risk assessment, molecular mechanisms of toxicity of endocrine disrupting chemicals (EDCs) and prevention of toxicity of anticancer drugs. His research on biomarkers of exposure to environmental toxicants using fish models has been extensively cited. Using biomarker approach it was shown that oxidative stress biomarkers could be used for monitoring the water quality of river Yamuna. A number of new biomarkers such as protein carbonyls were used for the first time in exposure monitoring and validate in field studies. The other area of his research focuses on prevention of toxicity of anticancer drugs using herbal extracts which are used in Indian systems of medicine. His recent research in this area has focussed on study of urothelial transmembrane proteins (uroplakins) and their expression in response to exposure to anticancer drug cyclophosphamide. These proteins play vital role in membrane integrity and one of the constituents of aged garlic extract, S-allyl cysteine has been shown to provide protection to uroplakins. Research on EDCs has revealed modulatory effects of nutritional factors on their toxicity with special reference to male reproductive system. Recently, he has undertaken research to unravel the molecular interaction of EDCs (bisphenol A) with peroxisome proliferator-activated receptors.

Proposer: Prof. N.K. Ganguly, Seconder: Dr.. Seyed Ehtesham Hasnain


1. Fatima M, Ahmad I, Sayeed I, Athar M, Raisuddin S (2000). Pollutant-induced over-activation of phagocytes is concomitantly associated with peroxidative damage in fish tissues. Aquatic Toxicology 49 (4):243-250. (if=4.129, ci=118)

2. Sharma N, Trikha P, Athar M, Raisuddin S (2001). Inhibition of benzo[a]pyrene- and cyclophoshamide-induced mutagenicity by Cinnamomum cassia. Mutation Research, 480-481: 179-188. (if=2.133, ci=54)

3. Bin-Hafeez B, Haque R, Parvez S, Pandey S, Sayeed I, Raisuddin S (2003). Immunomodulatory effects of fenugreek (Trigonella foenum graecum L.) extract in mice. International Immunopharmacology 3 (2): 257-265. (if=2.956, ci=144)

4. Sayeed I, Parvez S, Pandey S, Bin-Hafeez B, Haque R, Raisuddin S (2003). Oxidative stress biomarkers of exposure to deltamethrin in freshwater fish, Channa punctatus Bloch. Ecotoxicology and Environmental Safety, 56 (2): 295 –301. (if=3.743, ci=302)

5. Pandey S, Parvez S, Sayeed I, Haque R, Bin-Hafeez B, Raisuddin S (2003). Biomarkers of oxidative stress: a comparative study of river Yamuna fish Wallago attu (Bl. & Schn.). Science of Total Environment, 309 (1-3): 105-115. (if=4.900, ci=263)

6. Ali M, Parvez S, Pandey S, Atif F, Kaur M, Rehman H, Raisuddin S (2004). Fly ash leachate induces oxidative stress in freshwater fish Channa punctata (Bloch). Environmental International 30: 933-938. (if=7.088, ci=43)

7. Bhatia K, Kaur M, Atif F, Ali M, Rehman H, Rahman S, Raisuddin S (2006). Aqueous extract of Trigonella foenum graecum L. ameliorates additive urotoxicity of buthionine sulfoximine and cyclophosphamide in mice. Food & Chem Toxicol 44 (10): 1744-1750 (if=3.778, ci=49)

8. Pandey S, Parvez S, Ansari RA, Kaur M, Hayat F, Ahmad F, Raisuddin S (2008). Effects of exposure to multiple trace metals on biochemical, histological and ultrastructural features of gills of a freshwater fish, Channa punctata Bloch.Chem-Biol Intera (if=3.143, ci=158)

9. Rashid H, Ahmad F, Rahman S, Ansari RA, Bhatia K, Kaur M, Islam F, Raisuddin S (2009). Iron deficiency augments bisphenol A-induced oxidative stress in rats. Toxicology 256 (1-2):7-12. (if=3.582, ci=26)

10. Anjum S, Rahman S, Kaur M, Ahmad F, Rashid H, Ansari RA, Raisuddin S (2011). Melatonin ameliorates bisphenol A-induced biochemical toxicity in testicular mitochondria of mouse. Food Chem. Toxicol. 49 (11): 2849-2854. (if=3.778, ci=32)

329

SHARMA, G.TARU (b 1965), Principal Scientist and Head Director, Centre of Advanced Faculty Training in Veterinary Physiology, Division of Physiology and Climatology, ICAR-IVRI, Izatnagar-243122


It gives me great pleasure to strongly recommend and nominate Dr. G. Taru Sharma, ICAR-IVRI for the NASI Fellow. She has conducted outstanding basic and applied studies on buffalo reproduction. Dr. Sharma has developed a novel, innovative and efficacious three-dimensional (3D) microenvironment model for extended in vitro culture of buffalo preantral follicles (PFs) using gel synthetic surface matrix and gel droplet micro encapsulation. She has shown that co-culture of antral ovarian follicles with PFs is beneficial for long term growth, development and survival of pre-antral follicles as it got doubled, using this method and therefore, the oocytes. Oocytes derived from PFs were subjected to IVF and the embryos thus generated were used to derive buffalo pluripotent stem cells and proved the teratogenic nature of such cells. First global report for the elucidation, expression pattern profile, molecular characterization of developmental important genes for in-vitro produced & in-vivo derived buffalo (Bubalus bubalis) embryos. These basic studies will help choosing healthy embryos, required for various assisted reproductive technologies and will be extremely useful for buffalo reproduction. Further, she has developed efficient technique for buffalo female germplasm (PFs, Oocytes & Embryos) cryo-conservation using indigenously developed cryodevice. She has also done excellent studies on translational feasibility and application of adult & fetal stem cells, bone marrow, fetal adnexa from livestock and pets, standardized cryopreservation and banking strategies for the stem cells. Demonstrated feasibility of therapeutic application of mesenchymal stem cell in experimental model, it will help utilization of stem cells for therapeutic application in animals.

Proposer: Dr. V.P. Kamboj, Seconder: Dr. Smita D. Mahale


1. G. Taru Sharma and K. Loganathasamy (2007) Effect of meiotic stages during in vitro maturation on the survival of vitrified- thawed buffalo oocytes. Veterinary Research Communication 31 (7) 881-893. (if=1.933, ci=29)

2. G. Taru Sharma Pawan K. Dubey and S.K.Meur (2009) Survival and developmental competence of buffalo preantral follicles using three dimensional collagen gel culture system. Animal Reproduction Science 114; 115-124 (if=1.647, ci=34)

3. G. Taru Sharma, Pawan K. Dubey and G. Sai Kumar. (2010) Effects of IGF-1, TGF-α plus TGF-β1 and bFGF on in vitro survival, growth and apoptosis in FSH-stimulated buffalo (Bubalus bubalis) preantral follicles. Growth Hormone and IGF Research 20:319-325.(if=0.70, ci=31)

4. G. Taru Sharma, Pawan K. Dubey and Vikash Chandra. (2010). Morphological changes, DNA damage and embryonic developmental competence of in vitro matured, vitrified-thawed buffalo (Bubalus bubalis) oocytes: A comparative study of two cryoprotectants and two cryodevices. Cryobiology 60: 315-321. (if=1.35, ci=30)

5. Dangi S S, Gupta M, Maurya D, Yadav V P, Panda R P, Singh G, Mohan N H, Bhure S K, Das B C, Bag S, Mahapatra R K, Sharma, G.Taru, Sarkar M. (2012). Expression Profile of HSP Genes during Different Seasons in Goats (Capra hircus). Tropical Animal Health Production. 44(8)1905-1912. (if=1.22, ci=73)

6. Kumar Lalit., Panda, R. P., Hyder, I., Yadav, V.P., Sastry, K. V. H., Sharma, G. Taru, Mahapatra, R. K., Bag, S., Bhure, S. K., Das, G. K., Mitra, A. and Sarkar, M. (2012) Expression of leptin and its receptor in corpus luteum during estrous cycle in buffalo (Bubalus bubalis). Animal Reproduction Science135: 8– 17. (if=1.647, ci=38)

7. Pawan K. Dubey,VrajeshTripathi, Ram Pratap Singh, G. Saikumar, Amar Nath, Pratheesh, M.D., Nitin Gade and G. Taru Sharma (2012) Expression of nitric oxide synthase isoforms in different stages of buffalo (Bubalus bubalis) ovarian follicles: effect of nitric oxide on in vitro development of preantral follicle. Theriogenology77; 280-291. (if=2.136, ci=31)

8. Pratheesh M.D., Nitin E Gade, A. Nath, P K Dubey, Amar Pal, G. Saikumar, Bhaskar Sharma and G. Taru Sharma (2013). Isolation and characterization of caprine mesenchymal stem cells derived from amniotic fluid. Research in Veterinary Science 94: 313–319.(if=1.616, ci=40)

9. Rahul Kumar Udehiya, Amarpal, H.P. Aithal, P. Kinjavdekar, A.M. Pawde, and G. Taru Sharma (2013) Comparison of autogenic and allogenic bone marrow derived mesenchymal stem cells for repair of segmental bone defects in rabbits. Research in Veterinary Science 94 743–752. (if=1.616, ci=36)

10. V. Babitha, R.P. Panda, V.P. Yadav, V.S. Chouhan , S SDangi, F.A. Khan, G. Singh, S. Bag, G. Taru Sharma, W.J. Silvia, M. Sarkar. (2013) Amount of mRNA and localization of vascular endothelial growth factor and its receptors in the ovarian follicle during estrous cycle of water buffalo (Bubalus bubalis). Animal Reproduction Science 137: 163– 176. (if=1.647, ci=29)

330

SUBBIAH, POOPATHI (b 1962), Scientist-F, Vector Control Research Centre (ICMR), Pondicherry-605006


Dr.S.Poopathi, a senior scientist and vector control specialist from Indian Council of Medical Research for fellowship in Indian Academy of Sciences. He has over 27 years of research experience in ICMR, the apex medical organization in our country. He is an eminent scientist in ‘Entomology’. His distinctive scientific performance as reflected in more than 100 publications and almost all have first and corresponding author in reputed journals and three Indian patents. Two products were transferred to ICMR for commercialization. Having trained in Institute Pasteur, France on molecular mechanism of insecticidal resistance, he identified in-vitro binding assay of bacterial toxins and this finding is being widely followed for studying mechanism of resistance in medical and agriculture fields. His thrust areas of research continued to in neglected areas of research in India focusing on control of vector borne diseases. Recently he has isolated 31 new bacterial isolates from natural re-sources for mosquito control. His research proposals had high rating and reflected several grants from DST, DBT, DSTE and ICMR etc. His findings on “Chicken feather waste” as source of bio-pesticide production in mosquito control (Indian Patent No: 255023/2013) and demonstration of de-hairing enzymes in culture supernatants of Bti deserves appreciations. Dr.Poopathi is the recipient of A.B.J. Abdul Kalam Award, ICMR-Award, Technology Achievement Award, Sushruta Best Scientist Award, Recognition Award, Life-time Achievement Award etc. Member in professional bodies, Executive editor and Editorial Board member in more than 27 journals and deserves to be more suitable. I strongly recommend his candidature for Fellowship.

Proposer: Prof. Umesh Chandra Srivastava, Seconder: prof.Tridibes Adak


1. Mani, C, Selvakumari, J, Yeon Soo Han, Yong Hun Jo and Poopathi, S (2017). Molecular Characterization of Mosquitocidal Toxin (SLP) from Bacillus cereus VCRC B540. Appl.Biochem.Biotech. Appl.Biochem.Biotech. DOI 10.1007/s12010-017-2602-5 (if=1.75, ci=38)

2. Mani, C, Sundarapandian, SM, Poopathi, S (2015). Identification and characterization of a novel marine Bacillus cereus VCRC-B540 for mosquito control. Biocontrol, 60: 71-79 (if=2.25, ci=83)

3. Poopathi S, De Britto R.L.J, Lakshmi Praba L, Mani C, Praveen M (2015). Synthesis of silver nanoparticles from Azadirachta indica – a most effective methods for mosquito control. Environmental Science and Pollution Research 22: 2956-2963. (if=2.76, ci=52)

4. Poopathi S, Mani, C, Ragul K, Sundarapandian SM, (2014) Isolation of novel mosquitocidal bacteria (Bacillus thuringiensis, B.sphaericus and B.cereus) from excreta of arid birds. Indian Journal of Experimental Biology, 52: 739-747 (if=1.20, ci=32)

5. Poopathi, S, Mani, C, Athisaya Mary, K, and Balagangadharan K (2014). Hexamerin a novel protein associated with Bacillus sphaericus resistance in Culex quinquefasciatus. Applied Biochemistry and Biotechnology. 172: 2299-2307 (if=1.75, ci=61)

6. Poopathi, S., C. Mani, K. Thirugnanasambantham, Niyaz Ahmad Ahangar, K. Balagangadharan (2014). Identification and characterization of a novel marine Bacillus cereus for mosquito control. Parasitology Research. 113 (1) 323-332 (if=2.02, ci=22)

7. Poopathi, S., C. Mani, V. Vignesh, V. Lakshmi Praba (2013). Genotypic diversity among newly isolated mosquitocidal bacteria (Bacillus sphaericus, B.thuringiensis and B. cereus). Applied Biochemistry and Biotechnology): 171 (8): 2233-2246 (if=1.75, ci=42)

8. Poopathi, S and B. Archana (2013) Management of waste product from watermelon for culture and production of mosquitocidal toxins (bio-pesticide). International Journal of Environment and Waste Management 12 (4): 442-452 (if=1.65, ci=18)

9. Poopathi, S and B. Archana (2012) Wastewater Management from Slaughterhouse -A New Approach to Control Mosquitoes. Water Air & Soil Pollution.223: 3263-3270 (if=1.72, ci=23)

10. Poopathi, S and S. Abidha (2012) Use of clarified butter sediment waste from dairy industries for the production of mosquitocidal bacteria. International Journal of Dairy Technology 65 (1) 152-157 (if=1.28, ci=34)

331

TRIPATHI, BHUPENDRA NATH (b 1962), Director, National Research Centre on Equines-National Centre for Veterinary Type Culture,Sirsa Road, Hisar


This gives me great pleasure to bear testimony to the excellent scientific acumen and technology innovation of Dr Tripathi who has some outstanding contributions in the area of structural genomics and animal health and deserves recognition as a NASI fellow. Dr Tripathi’s extensive research focused on molecular pathogenesis, immunology and diagnosis of bacterial and viral diseases of animals. His pioneering work on M.paratuberculosis earned him international recognition (Ref.3-5). He identified for the first time genes in Salmonella pathogenicity island 2 (SPI-2) that are required for the induction of both systemic and enteric salmonellosis in calves (Ref.1). His research on viruses includes global first lab animal model for equine influenza virus (EIV), structural genomics of EIV, generation of recombinant EIV using reverse genetics and bacterial artificial chromosome (BAC) for equine herpes virus (vaccine development) (Ref. 6,7,10). His recent work includes identification of host cell kinases (SERCA, MNK1, etc) for efficient virus replication so as to target them for development of antiviral drugs (Ref. 8, 9). He is significantly contributing to development of Veterinary Type Culture Repository at NRCE, which holds of more than 3200 animal microbes. Dr Tripathi is recipient of Best University Teacher award, outstanding pathologist award, International Wellcome Trust fellowship for Post-doc work, etc. He is fellow of National Academy of Veterinary Sciences, Indian Assoc. of Vet Pathologists (IAVP), and Indian Society for Immunology and Biotechnology. He is currently Task Force member of DBT, Govt of India, and Director of NRCE, and Project Coordinator, NCVTC, Hisar.

Proposer: Dr. M.L. Madan, Seconder: Prof. Parimal Roy


1. Bispham, J., Tripathi, B.N., Watson, P.R. and Wallis, T.S. 2001. Salmonella pathogenicity island-2 influences both systemic salmonellosis and Salmonella induced enteritis in calves. Infection and Immunity, 69(1):367-377. (if=3.593, ci=114)

2. Kumar, P., Tripathi, B.N., Sharma, A.K., Kumar, R., Sreenivas, B.P., Singh, R.P., Dhar, P. and Bandyopadhyay S.K. 2004. Pathological and immunohistochemical study of experimental peste des petits ruminants (PPR) virus infection of goats. Journal of (if=2.323, ci=66)

3. Sivakumar P., Tripathi. B.N. and Singh, N. 2005. Detection of Mycobacterium avium subsp.paratuberculosis from intestinal and lymph node tissues of water buffaloes by PCR and bacterial culture. Veterinary Microbiology, 108(3-4): 263-270. (if=2.628, ci=75)

4. Tripathi, B.N., Sivakumar, P., Paliwal, O.P. and Singh, N. 2006. Comparison of tissue PCR, bacterial culture, johnin and serological test in the diagnosis of naturally Zoonosis and Public Health occurring paratuberculosis in goats. Veterinary Mic (if=2.628, ci=36)

5. Sivakumar P., Tripathi, B.N. and Nem Singh. 2013. Mechanisms of Mycobacterium avium subsp. paratuberculosis induced apoptosis and necrosis in bovine macrophages. Veterinary Microbiology, 165(3-4): 392-401. (if=2.628, ci=10)

6. Pavulraj, S., Bera, B.C., Joshi, A., Anand, T., Virmani, M., Vaid, R.K., Shanmugasundaram, K., Gulati, B.R., Rajukumar, K., Singh, R., Misri, J., Singh, R.K., Tripathi, B.N. and Virmani, N. 2015. Pathology of equine influenza virus (H3N8) in murin (if=2.81, ci=1)

7. Kumar, N., Bera, B.C., Greenbaum, B.D., Bhatia, S., Sood, R., Pavulraj, S., Anand, T. and Tripathi B.N. 2016. Revelation of influencing factors in overall codon usage bias of equine influenza viruses. PLOS One, http://dx.doi.org/10.1371/journal.po (if=2.81, ci=12)

8. Kumar, N., Barua, S., Riyesh, T., Singh, S.V., Sharma. D.K., Sharma, S. and Tripathi B.N. 2016. Complexities in isolation and purification of multiple viruses from mixed viral infection: viral interference, persistence and exclusion, PLOS One, 11( (if=2.81, ci=6)

9. Khandelwal, N., Yogesh C., Krishan D.A., Riyesh, T., Chikkahonnaiah, N., Sharma S., Jindal, N., Tripathi, B.N., Barua, S. and Kumar, N. 2017. Emetine inhibits replication of RNA and DNA viruses without generating drug-resistant virus variant (if=4.271, ci=Recently published)

10. Bera, B.C., Virmani, N., Kumar, N., Anand, T., Pavulraj, S., Rash, A., Elton, D., Rash, N., Bhatia, S., Sood, R., Singh, R.K. and Tripathi, B.N. 2017 Genetic and codon usage bias analyses of polymerase genes of equine influenza virus and its rel (if=3.729, ci=Recently published)

332

JADHAO, ARUN GOVINDRAOJI (b 1960), Professor, Department of Zoology, RTM Nagpur University, Nagpur


Prof. Jadhao did M.Sc. and Ph.D. in Zoology from Nagpur University, Nagpur. Subsequently, he received prestigious fellowship of Alexander von Humboldt (AvH) Foundation, Germany to pursue postdoctoral training in Germany (1994-96) and further worked at different institutes in Germany. He made significant contributions in the area of neuroanatomy and neuroendocrinology. The nominee made a novel finding which shows the anatomically distinct two brain types in the same gender of the fish species and this has been shown for first time in any vertebrate animals demonstrating the inter-sexual and intra-sexual dimorphisms within the males and within females brain, which predominantly seen in the preoptic and tuberal region. Probably such dimorphisms may responsible for the different reproductive behaviors within the same gender. Further, he made a significant contribution in identifying neuronal descending pathways in the central nervous system (CNS) and demonstrated different neuronal cell populations of the brain that projecting to the spinal cord extending up to 25th segment and also shows regeneration capacity in fish. He also identified the gender differences in the expression of galanin and calcium binding protein in the fish preoptic area which controls the hormonal regulation by the pituitary. He identified several novel peptidergic, aminergic, nitrinergic and calcium binding proteins (CaBPs) containing neurons, some co-expressing these substances, and participating in hypophysial regulation using immunocytochemical and fluorescence techniques. For the first time his group has reported the presence of GnIH in the olfactory system and pituitary gland of fish and frog, confirming its role in the hormonal regulation.

Proposer: Prof. P. D. Prasada Rao , Seconder: Dr. Subeer S. Majumdar


1. Jadhao, A. G., Malz, C. R. (2004): Nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase activity in the brain of a cichlid fish, with remarkable findings in the entopeduncular nucleus: A histochemical study. J. Chem. Neuroanat. 27: 75-86 (if=2.5, ci=12)

2. Jadhao, A. G., Malz, C. R. (2003): Localization of NOS-I isoform in the diencephalon and pituitary gland of the catfish, Synodontis multipunctatus: An Immunocytochemical Study. Gen.Comp. Endocrinol. 132(2): 278-283. (if=3.28, ci=15)

3. Jadhao, A. G., D´Aniello, B., Malz, C. R., Pinelli, C., Meyer, D. L. (2001): Intra-sexual and inter-sexual dimorphisms of the red salmon prosencephalon. Cell Tissue Res. 304(1): 121-140. (if=3.33, ci=13)

4. Jadhao, A. G., Pinelli C. (2001): Galanin-like Immunoreactivity in the brain and pituitary gland of the ‘four-eyed’ fish, Anableps anableps. Cell Tissue Res. 306(2):309-318. (if=3.33, ci=20)

5. Jadhao, A. G., Meyer D. L. (2000): Sexually dimorphic distribution of galanin in the preoptic area of red salmon, Oncorhynchus nerka. Cell Tissue Res. 302(2):199-203. (if=3.33, ci=23)

6. D´Aniello, B., Pinelli, C. Jadhao, A. G., Rastogi, R. K., Meyer, D. L. (1999): Comparative analysis of FMRFamide-like immunoreactivity in the brain of the caiman (Caiman crocodilus) and the turtle (Trachemys scripta elegans). Cell Tissue Res. 298(3): (if=3.33, ci=19)

7. Meyer, D. L., Jadhao, A. G., Kicliter, E. (1996): Soybean agglutinin binding by primary olfactory and primary accessory olfactory projections in different frogs. Brain Res. 722:222-226. (if=2.82, ci=19)

8. Prasada Rao, P. D., Jadhao, A. G., Sharma, S. C. (1993): Topographic organization of descending projection neurons to the spinal cord of the goldfish, Carassius auratus. Brain Res. 620:211-220. (if=2.82, ci=21)

9. Sharma, S. C., Jadhao, A. G., Prasada Rao, P. D. (1993): Regenration of supraspinal projection neurons in the adult goldfish. Brain Res. 620:221-228 (if=2.82, ci=61)

10. Prasada Rao, P. D., Jadhao, A. G., Sharma, S.C. (1987): Descending projection neurons to the spinal cord of the goldfish, Carassius auratus. J. Comp. Neurol. 265:96-108. (if=3.7, ci=97)

333

KAMARAJU, RAGHAVENDRA (b 1957) Scientist –G, National Institute of Malaria Research, Sector 8 Dwarka, New Delhi-110077


The nominee Dr. Raghavendra is an established investigator in the area of Entomology & Malariology, made significant contributions to the fields of vector control, insecticide resistance and its management- both of relevance to public health. His Ph.D. work gave, for the first time evidence for the biochemical mechanisms underlying insecticide resistance, differential responses to different classes of insecticides, kinetics of development of resistance among sympatric An. culicifacies sibling species, led to suggesting specific indoor residual spray strategy for vector control. His work on pyrrole class insecticide was acclaimed by WHO, led to innovation of combination LLINs with insecticides. As Indian PI of multi-country WHO research project on universal LLIN coverage for population at risk of malaria with >80% coverage, showed impact on transmission of malaria and management of asymptomatic cases, even with loss of 13%susceptibility, provided leads for use of LLINs in the presence of insecticide resistant malaria vectors. A WHO project is initiated to determine diagnostic dosages of neo-nicotinoids for susceptibility testing in mosquitoes for effective management of multiple insecticide resistance. He is associated with WHO, GoI, ICMR on several decision making committees and working groups on vector control policy. His laboratory published work led to co-patenting of a plant extract as promising larvicide. He is scientist-in-charge of WHO collaborating centre for phase I testing of insecticides since 2012 and the facility is being upgraded for GLP compliance. He guided more than 20 PhD/MSc students, published 110 papers in peer-reviewed international journals and 12 articles as book chapters.

Proposer : Dr. Sarala Karumuri Subbarao, Seconder : Prof. Kambadur Muralidhar Ten Best Publications : 1. Raghavendra K*, Cornel A J, Reddy B P N, Collins F H, Nanda N, Chandra D, Verma V, Dash A P, Subbarao S K, 2009. Multiplex PCR assay and phylogenetic analysis of sequences derived from D2 domain of 28S rDNA distinguished members of the Anopheles culicifacies complex into two groups, A/D and B/C/E. Infection, Genetics and Evolution 9: 271–277. (if=3.264, ci=17) 2. Raghavendra K*, Verma V, Srivastava H C, Gunasekaran K, Sreehari U, Dash A P, 2010. Persistence of DDT, malathion and deltamethrin resistance in Anopheles culicifacies after their sequential withdrawal from indoor residual spraying in Surat district Indian J Med Res 132: 260-264. (if=1.661, ci=23) 3. Raghavendra K*, Barik T K, Sharma P, Bhatt R M, Srivastava H C, Sreehari U, Dash A P, 2011. Chlorfenapyr: a new insecticide with novel mode of action can control pyrethroid resistant malaria vectors. Malar J 10:16. (if=3.07, ci=53) 4. Raghavendra K*, Barik T K, Reddy B P N, Sharma P, Dash A P, 2011. Malaria vector control: from past to future. Parasitol Res 108:757–779. (if=2.329, ci=173) 5. Silica nanopartical: a potential new insecticide for mosquito vector control. If=2.329, ci=41 6. Kleinschmidt I, Mnzava AP, Kafy HT, Mbogo C, Bashir AI, Bigoga J, Adechoubou A, Raghavendra K*, Knox TB, Malik EM, Nkuni ZJ, Bayoh N, Ochomo E, Fondjo E, Kouambeng C, Awono-Ambene HP, Etang J, Akogbeto M, Bhatt R, Swain DK, Kinyari T, Njagi K, Muthami L, Subramaniam K, Bradley J, West P, Massougbodji A, Okê-Sopoh M, Hounto A, Elmardi K, Valecha N, Kamau L, Mathenge E and Donnelly MJ, 2015. Design of a study to determine the impact of insecticide resistance on malaria vector control: a multi-country investigation. Malar J 14:282. (if=3.07, ci=34) 7. Chourasia MK, Raghavendra K*, Bhatt RM, Swain DK, Meshram, Jayant K. Meshram MK, Suman S, Dubey V, Singh G, Prasad KMN, Kleinschmidt I, 2017. Additional burden of asymptomatic and sub-patent malaria infections during low transmission season in forested tribal villages in Chhattisgarh, India. Malaria Journal 16:320. (if=3.07, ci=0) 8. Raghavendra K*, Chourasia MK, Swain DK, Bhatt RM, Uragayala S, Dutta GDP, Kleinschmidt I. Monitoring of long-lasting insecticidal nets (LLINs) coverage versus utilization: a community-based survey in malaria endemic villages of Central India. Malaria Journal . 2017. 16:467. (if=3.07, ci=0) 9. Raghavendra K*, Sharma P, Verma V, Natarajan E, Barik TK, Bhatt RM, Dash AP, 2017. Temporo-spatial distribution of insecticide resistance in Indian malaria vectors in last quarter-century (1991-2016) emphasize the need for regular resistance monitoring and management. J Vector Borne Dis. 54 : 111–130. (if=0.8, ci=2) 10. Chourasia MK, Raghavendra K*, Kleinschmidt I, Bhatt RM, Swain DK, Knox TB, Valecha N, 2017. Impact of long-lasting insecticidal nets on prevalence of subclinical malaria among children in the presence of pyrethroid resistance in Anopheles culicifacies in Central India. International Journal of Infectious Diseases.57:123-129. (if=2.22, ci=1)

334

KAR CHOWDHURI, DEBAPRATIM (b 1960) Chief Scientist & Professor, AcSIR; CSIR-Indian Institute of Toxicology Research, Lucknow


The nominee has made significant contributions in the areas “stress biology and genotoxic stress”. His work received first-rate citations (65-pub;>1600 citations; Nature group journals) and award of prestigious international collaborative project (Major:UK-IERI; British Council). He developed and validated Drosophila model transgenic for stress genes for assessing chemicals-induced cellular toxicity for the first time; application in environmental monitoring studies; nanomaterials-safety, environmental chemical detection in different matrices and hsp70 expression as the first-tier bio-indicator of cellular adversity and as a redox-buffer and elucidation of the underlying mechanism (Environ.-Hlth.-Perspect,2003,111; BBA, 2005, 1725, 81; BBA, 2007, 1770, 1382; Ecotoxicology-&-Environmental-Safety,(Highlighted-article), 2009, 72, 1652; Toxicol. -Appl. -Pharmacol., 2009, 235, 226; Life-Sci., 2010, 86, 377; BBA, 2013, 1830,2256; Age,2014, 25, 1139;Free-Radical-Biology-&-Medicine,2015, PMID- 25746179,e-pub). Global gene expression profiling studies revealed that beside hsp70, other stress associated genes play role in better stress adaptability displayed by exposed organism. Recently, a mutation in methusalah gene (Class-II-GPCR) was shown for the first time to confer significant rescuing effect on dopaminergic neurons in chemical-induced Parkinson disease model of Drosophila and elucidation of underlying mechanism. Subsequently, metabolome profiling studies showed relevance to human as part of GPCR based drug targeting and parallel findings in human PD patients (Chemosphere, 2011, 82, 370; Neurobiology-of-Aging, 2014, 35, 2419, e1-16; PLoS-One,2014, 9(6),e98886;Molecular-Neurobiology,2015,PMID-25428622,e-pub). In genotoxic stress area, methods for the detection of single-strand-break, double-strand-break and oxidative DNA damage were developed and validated. He was the first to demonstrate (global gene profiling, genetic, miRNA profiling) that complex mechanism of DNA damage in Cr(VI)-exposed organism follows perturbation of non-homologous-end-joining DSB-repair. He also demonstrated that perturbed DNA repair in chemical-(DDVP)-exposed organism is due to faulty pre- and post-replication repair pathways along with alkylating and oxidative DNA damage (Environ. Mol. Mutagenesis,2005,46,189;Environ.-Mol.-Mutagenesis,2008,49,206;Mutation-Res,2011,722,44;Mutation-Res,2011,726,222;Mutation-Res-FMMM,2014,747–748,28;Mutation-Res,2014,766,35;J Hazardous Materials,2015,283,558)

Proposer : Prof. Debi P. Sarkar, Seconder : Prof. Prahlad C. Ghosh Ten Best Publications : 1. Pandey A, Khatoon R, Saini S, Vimal D, Patel DK, Narayan G, Chowdhuri DK, (2015) : Efficacy of methuselah gene mutation towards tolerance against dichlorvos exposure to Drosophila melanogaster, Free Radical Biology and Medicine doi: 10.1016/ j.freeradbiomed.2015.02.025 (In Press).( if=5.78) 2. Shukla AK, Pragya P, Chaouhan HS, Patel DK, Abdin MZ, Chowdhuri DK, (2014): A mutation in Drosophila methuselah resists paraquat induced Parkinson-like phenotypes, Neurobiology of Aging 35 (10), 2419. e1-2419. e16. (If=6.16, ci=4) 3. Mishra M, Sharma A, Shukla AK, Pragya P, Murthy RC, de Pomerai, Chowdhuri DK, (2013): Transcriptomic analysis provides insights on hexavalent chromium induced DNA double strand breaks and their possible repair in midgut cells of Drosophila melanogaster larvae, Mutation Research -Fundamental and Molecular Mechanisms of Mutagenesis 747, 28-39.(if=4.44, ci=10) 4. Pandey A, Chandra S, Chauhan LKS, Narayan G, Chowdhuri DK, (2013) : Cellular internalization and stress response of ingested amorphous silica nanoparticles in the midgut of Drosophila melanogaster, Biochimica et Biophysica Acta (BBA)-General Subjects 1830 (1), 2256-2266. (if= 5.00, ci=11) 5. Sharma A, Mishra M, Shukla AK, Kar Chowdhuri D. (2011): Validation and application of Drosophila melanogaster as an in vivo model for the detection of double strand breaks by neutral Comet assay. Mutation Research, 721: 142-6 (if= 2.94, ci=11) 6. Gupta SC, Sharma A, Mishra M, Mishra RK, Kar Chowdhuri D. (2010): Heat shock proteins in toxicology: How close and how far? (Mini Review), Life Sciences, 86: 377-84 (if= 2.45, ci=133) 7. Singh MP, Reddy MM, Mathur N, Saxena DK, Chowdhuri Kar D. (2009): Induction of hsp70, hsp60, hsp83, and hsp26 and oxidative stress markers in benzene, toluene and xylene exposed Drosophila melanogaster: role of ROS generation. Toxicology and Applied Pharmacology, 235: 226-43. (Among Top 25 hot articles of the Journal Sr. No. 18). (if= 3.99, ci=54) 8. Siddique HR, Sharma A, Gupta SC, Murthy RC, Dhawan A, Saxena DK and Kar Chowdhuri D. (2008) : DNA damage induced by industrial solid waste leachates in Drosophila melanogaster: A mechanistic approach. Environmental & Molecular Mutagenesis, 49: 206-16 (if= 3.49 ci=18) 9. Gupta SC, Siddique HR, Mathur N, Vishwaskarma AL, Mishra RK, Saxena DK and Kar Chowdhuri D. (2007): Induction of hsp70, alterations in oxidative stress and apoptosis against dichlovos exposure in transgenic Drosophila melanogaster: modulation by reactive oxygen species. Biochemica et Biophysica Acta (BBA), 1770): 1382-94 (if= 3.85, ci=37) 10. Mukhopadhyay I, Saxena DK and Kar Chowdhuri D. (2003): Hazardous effect of effluent from chrome plating industry: 70kDa heat shock protein expression as a marker of cellular damage in transgenic Drosophila melanogaster (hsp70-lacZ). Environmental Health Perspectives, 111: 1926-32 [Among the top 10 articles (Sr. No. 7) in stress biology domain] (if= 7.02, ci=38)

http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1098-2280

335

PRAKASH, SOAM (b 1956), Professor,Dayalbagh Educational Institute,Dayalbagh, Agra


Prof.Soam Prakash,FAZ contributions in the area of Consciousness and evolution of consciousness in microbes, animals and Man as expert, supervisor of Thesis with multidisciplinary research capabilities in Nano Parasitology and Public health research for last 20 years and would be happy to nominate him for fellowship of the academy for the reasons described below:1.One of the first Indian tosupervise thesis on evolution of consciousness(2018) at DEI with vector control expertise to utilize,synthesize silver and gold nano particles for Malaria, Filariasis, Dengue, Chickengunia control.(69 research publications)One of the first Indian to initiate Consciousness research to trace volutionary aspect of onsciousness, providing outstanding support to create center of excellence in formulating consciousness and Nano research center at Dayalbagh Educational Institute.He has published hundred internationalpublications,Guided 10 Ph.Ds in diversified fields likevector control,Nano biotechnology,public health and successfully completed 10 major projects from DST,AICTE,UGCetc.In last 20 years and has been awarded fellowship from Academy of Zoology.Making a hole in the wall,helping underprivileged people, who received 100% employment opportunity.He could managed to chair 37 international conferences,and is reviewing at least 30 international journals, 6 journals of repute on special issues(4) and has been nominated as Editor for many journals of interdisciplinary research. He has visited USA, Finland, France, Canada and UK for giving 34 invited lectures in diversified topics earning awards.

Proposer: Prof.V.P.Sharma, Seconder: Prof. Anand Mohan


1. Namita, Soni and Prakash,S(2012)S.Efficacy of fungus mediated silver and gold nanoparticles against Aedes aegypti larvae..Parasitology Researchv110issue1,175-184 (if=2.329, ci=98)

2. Namita, Soni and Prakash,S(2012)Synthesis of gold nanoparticles by the fungus Aspergillus niger and its efficacy against mosquito larvae.Reports in Parasitologyvol2p-127 (if=2.329, ci=48)

3. Neetu,Vyas,KKdua,Prakash,S(2007) .Efficacy of Lagenidium giganteum metabolites on mosquito larvae with reference to nontarget organisms.Parasitology Research.V-101,issu2,380-390 (ci=43)

4. Namita Soni and Prakash,S.(2011)Factors affecting the geometry of silver nanoparticles synthesis in Chrysosporium tropicum and Fusarium oxysporum.American journal Of nanotechnology.American journal of nanotechnology.vol2,issue1,112-121 (if=-----, ci=31)

5. Prakash,Soam,Singh,G,Soni,Namita,Sharma,S.(2010).Pathogenicity of Fusarium oxysporum against the larvae of Culex quinquefasciatus (Say) and Anopheles stephensi (Liston) in laboratory.Parasitology Researchvol107.issue3,651-655 (if=2.329, ci=29)

6. Singh,Gavendra and Prakash,S.2009.Efficacy of Bacillus sphaericus against larvae of malaria and filarial vectors: an analysis of early resistance detection.Parasitology research,vol104.p-763 (if=2.329, ci=25)

7. Namita S,and Prakash,S.(2013).Efficacy of Bacillus sphaericus against larvae of malaria and filarial vectors: an analysis of early resistance detection.Adv.n Nanoparticle,vol2,p-125-132 (if=2.13, ci=26)

8. Namita S,and Praksh S,(2012)Fungal-mediated nano silver: an effective adulticide against mosquito.Parasitology Research.vol 111,issue5,p-2091-2098 (if=2..329, ci=19)

9. Preeti,V and Prakash,S.(2010Efficacy of Chrysosporium tropicum metabolite against mixed population of adult mosquito (Culex quinquefasciatus, Anopheles stephensii, and Aedes aegypti) after purification with flash chromatography).Parasitology research (if=2.329, ci=16)

10. Namita,S and Prakash,S,(2012)Entomopathogenic fungus generated Nanoparticles for enhancement of efficacy in Culex quinquefasciatus and Anopheles stephensi.Asian Pas cific Journv-2,Issue1,p-f356-f361al of Tropical Disases (if= (1.13), ci=15)

336

ROY, JAGAT KUMAR (b 1957), Professor, Banaras Hindu University, Varanasi


Using Drosophila as his model system, Prof. Jagat Kumar Roy has made significant contributions to chromosome organization and regulation of gene expression during development and differentiation. He unraveled the dynamic organization of heterochromatin and its differential replication in larval brain. His group showed regulation of developmental genes in Drosophila by the classical tumour suppressor genes. His elegant demonstration that homeotic transformation following perturbation in a segment polarity gene generates wings in all three thoracic segments (Emerald & Roy 1997, Nature 389:684) explains evolution of insect wings. His current research attempts to understand the molecular pathways regulated by Rab11, a G-protein-coding gene involved in vesicular trafficking. Using sophisticated genetic screens and confocal microscopy, he showed how Rab11 affected diverse cellular functions like membrane morphogenesis, cytoskeletal organization, cell adhesion, etc., as well as morphogenesis, viz., formation of eye, myogenesis and gonadogenesis. His studies also characterized development of malignant tumour in Drosphila brain due to mutaion in the dcp2 gene, coding for an RNA degradation protein. Dr Roy’s recent interest in the molecular etiology of cervix cancer has demonstrated the prevalence of HPV in women in eastern India and has shown that mutation in BRN3A is an important cellular factor in cervix cancer, which opens a novel approach in understanding of its molecular pathogenesis. Besides his sustained research contributions, Prof. JagatKumar Roy is one of the most popular teachers among students. His single minded exemplary commitment to teaching and research, and work ethic provide inspiration to students and colleagues alike.

Proposer : Prof. Rajiva Raman, Seconder : Prof.Subhash Chandra Lakhotia


1. Lakhotia S C, Roy J K, Kumar M (1979): A study of heterochromatin in Drosophila nasuta by the 5-bromodeoxyuridine-Giemsa staining technique. Chromosoma 72, 249-255 (if=3.26, ci=11)

2. Lakhotia S C, Roy J K (1981): Effects of Hoechst 33258 on condensation patterns of hetero- and euchromatin in mitotic and interphase nuclei of Drosophila nasuta. Exp Cell Res 132, 423-431 (if=3.557, ci=12)

3. Emerald B S, Roy J K (1997): Homeotic transformation in Drosophila. Nature 389, 684 (if=42.351, ci=9)

4. Emerald B S, Roy J K (1998): Organizing activities of engrailed, hedgehog, wingless and decapentaplegic in the genital discs of Drosophila melanogaster. Dev Genes Evol 208, 504-516 (if=2.179, ci=18)

5. Alone D P, Tiwari A K, Mandal L, Li M, Mechler B M, Roy J K (2005): Rab11 is required during Drosophila eye development. Int J Dev Biol 49, 873-879 (if=2.879, ci=31).

6. Sasikumar S, Roy J K (2009): Developmental expression of Rab11, a small GTP-binding protein in Drosophila epithelia. Genesis 47:32-39 (if=2.042, ci=8).

7. Bhuin T, Roy J K. (2009): Rab11 is required for myoblast fusion in Drosophila. Cell Tissue Res 336, 489-499 (if=3.333, ci=12).

8. Tiwari A K, Roy J K (2009): Mutation in Rab11 results in abnormal organization of ommatidial cells and activation of JNK signaling in Drosophila eye. Eur J Cell Biol 88, 445-460 (if=3.699, ci=8).

9. Singh D, Roy J K (2013): Rab11 plays an indispensable role in the differentiation and development of the indirect flight muscles in Drosophila. PlosOne 8, e73305 (if=3.73).

10. Bhuin T, Roy J K (2014): Rab proteins: the key regulators of intracellular vesicle transport. Exp Cell Res 328, 1-19 (if=3.557, ci=2).

337

MEDICAL & FORENSIC SCIENCES (Basic and Clinical Medical Sciences, Pharmacology, Anthropology, Psychology and Forensic Sciences, Human genetics, Reproduction

Biology, Neurosciences, Molecular Medicine)

AFZAL, MOHAMMAD (b 1959), Professor, Department of Zoology, Aligarh Muslim University, Aligarh

Member of the NASI: No (YON 2019, Medical & Forensic Sciences)

Mohammad Afzal has worked in consanguinity, inbreeding depression, human intelligence, quantitative traits, genetic disorders, brain tumors, population genetics and also natural products as antigenotoxic agents in in-vitro/in-vivo models (human/animal). Mohammad Afzal has established human genetics and toxicology laboratory in Aligarh and introduced human karyotyping, genetic and biological markers for diagnosis of diseases and lymphocyte culture for studying natural products. The running theme in his research especially recently has been how human beings respond to their biological nature, culture and environment on one hand, and also to chemical signaling at cellular level on the other as reflected in phenotypic expression of traits, potentials damages and diseases(genetic and epigenetic). Mohammad Afzal joined Aligarh Muslim University as a lecturer (1986) after his post doc training at AIIMS (1985-86), New Delhi under Dr. I.C Verma, and Ph.D from Zoology Deptt, Bhagalpur University (1984). Thereafter, he was appointed Reader (1997) and Professor (2006) in the Zoology Department (all cadres) Faculty of Life-sciences, Aligarh Muslim University. Being trained in genetics and molecular biology at AIIMS and CCMB, he has worked in CSIR and ICMR projects and conducted his own research projects (5) from ICMR, UGC, UPCST and MAAS. He has guided 20 research scholars for Ph.D and many M.Phils and M.Sc dissertations. He has published over 150 research papers in reputed journals with a citation score of 2242, h=27, i10=71. His illustrious students have since become Professor and Associate Professor in central and state universities in Departments of Zoology, Biosciences, Neurosciences and Human Genetics.

Proposer: Prof. Subrata Sinha, Seconder: Prof. S.N. Ghaskadbi


1. Afzal, M. (1988). Consequences of consanguinity on cognitive behaviour. Behav. Genet.18(50)583- 594 (if=2.036, ci=58)

2. Badaruddoza, Afzal, M.Akhtaruzzaman.(1994). Inbreeding and congenital heart diseases in a North Indian population. Clin. Genet.(45):288–291 (if=3.512, ci=61)

3. Siddique, Y.H., Afzal, M. (2004) Evaluation of genotoxic potential of synthetic progestin chloramadinone acetate. Toxicol Lett. 53(2):221-225. (if=3.166, ci=31)

4. Siddique, Y.H., Ara, G., Beg, T., Faisal, M., Ahmad, M., Afzal, M. (2008) Antigenotoxic role of Centellaasiatica L. extract against cyproterone acetate induced genotoxic damage in cultured human lymphocytes. Toxicology In Vitro. 22:10–17 (if=3.105, ci=54)

5. Shahi, M.H., Afzal, M., Sinha, S., et.al. (2010).Regulation of sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 20 and NKX2.2 and their epigenetic status in medulloblastoma and astrocytoma. BMC Cancer. 10:614 (if=3.288, ci=53)

6. Shahi, M.H., Afzal, M., Sinha, S., et.al. (2011) Expression and epigenetic modulation of sonic hedgehog-GLI1 pathway genes in neuroblastoma cell lines and tumors.Tumor Biol. 32:113–127 (if=3.650, ci=26)

7. Fareed M, Afzal M. (2014). Estimating the inbreeding depression on cognitive behavior: a population based study of child cohort. PLoS ONE 9(10):e109585. (if=2.806, ci=48)

8. Siddiqui S., Ahamad M.S., Jafri A., Afzal M., Arshad M. (2017) Piperine Triggers Apoptosis of Human Oral Squamous Carcinoma Through Cell Cycle Arrest and Mitochondrial Oxidative Stress. Nutr Cancer 69(5):791-799 (if=3.14, ci=03)

9. Fareed M., Kaisar Ahmad M., Azeem Anwar M., Afzal M., (2017) Impact of consanguineous marriages and degrees of inbreeding on fertility, child mortality, secondary sex ratio, selection intensity, and genetic load…. Pediatr Res. 81(1-1):18-26 (if=3.123, ci=03)

10. Firdaus F., Zafeer M.F., Waseem M., Ullah R., Ahmad M., Afzal M., (2018) Thymoquinone alleviates arsenic induced hippocampal toxicity and mitochondrial dysfunction by modulating mPTP in Wistar rats. Biomed Pharmacother 102:1152-1160 (if=3.457, ci=0)

338

BARTHWAL, MANOJ KUMAR (b 1973), Principal Scientist, CSIR-Central Drug Research Institute, Lucknow

Member of the NASI: Yes (YON 2019, Medical & Forensic Sciences)

Atherosclerotic cardiovascular phenotype clinically manifests into ischemic heart disease, peripheral artery disease and stroke leading to maximum number of cardiovascular deaths in India. Dr. Barthwal has focused on macrophage inflammation and foam cell formation, the two important aspects of atherosclerotic cardiovascular disease. Several elegant studies conducted in human monocyte & macrophages demonstrated role of protein kinase c (PKC), interleukin-1 receptor-associated kinase (IRAK), ERK-p67phox-Nox-2 axis in toll like receptor (TLR) and oxidized-low density lipoprotein (Ox-LDL) induced IL-1β production, inflammation and foam cell formation (J.Immunol.2011;187(5):2632-45,J.Lipid.Res.2014,55(7):1226-44,Cell.Mol.Immunol.2016;13(6):745-763,Bioessays.2016;38(7):591-604).A positive correlation between serum Ox-LDL and IL-1β and macrophage CD36-TLR crosstalk was observed during Ox-LDL-induced IL-1β production in systemic inflammatory response syndrome (SIRS) patients (J.Lipid.Res.2014;55(7):1226-1244). Therapeutic intervention of TLR-PKC-IRAK-ERK pathway in animal model prevented vascular smooth muscle cell proliferation and atherosclerosis (Arterioscler.Thromb.Vasc.Biol.2015; 35(6):1445-55).His laboratory also identified a novel curcuma longa derived herbal preparation that prevents dyslipidaemia, inflammation and atherosclerosis(Br.J.Nutr.2015;113(1):100-13,Br.J.Nutr.2013;110(3):437,J.Funct. Foods. 2015,16,152-163). Dr. Barthwal also played an important role in the co-development of an anti-thrombotic molecule which is at IND stage (US9206155B2).His recent work speculates the use of microRNA-99a mimics in diabesity treatment (Cell.Mol.Immunol.2018) as microRNA-99a targets TNF and consequently improves insulin sensitivity in diabetic obese mice. In his recent work Cilastozol ameliorated Angiotensin-II (Ang-II) induced heart failure with preserved Ejection Fraction (HFpEF) in obese mice. Thus Cilostazol might be useful in the subset of obese patients with high renin and Ang-II levels (J.Mol.Cell.Cardiol.2018). Overall Dr. Barthwals research significantly advances the cardiovascular area and suggests novel targets and therapeutic interventions.

Proposer: Prof. Tapas K. Kundu, Seconder: Dr. Madhu Dikshit


1. Reddy SS, Agarwal H, Barthwal MK. (2018) Cilostazol ameliorates heart failure with preserved ejection fraction and diastolic dysfunction in obese and non-obese hypertensive mice. J Mol Cell Cardiol. Oct;123:46-57. doi: 10.1016/j.yjmcc.2018.08.017. (if=5.3, ci=1)

2. Jaiswal A, Reddy SS, Maurya M, Maurya P, Barthwal MK.(2018). MicroRNA-99a mimics inhibit M1 macrophage phenotype and adipose tissue inflammation by targeting TNFα. Cell Mol Immunol. 2018 May 30. doi: 10.1038/s41423-018-0038-7. (if=7.6, ci=0)

3. Rana M, Kumar A, Tiwari RL, Singh V, Chandra T, Dikshit M, Barthwal MK (2016). IRAK Regulates Macrophage Foam Cell Formation by Modulating Genes involved in Cholesterol Uptake and Efflux. Bioessays Jul;38(7):591-604. (if=4.4, ci=4)

4. Singh A, Singh V, Tiwari RL, Chandra T, Kumar A, Dikshit M, Barthwal MK. (2015). The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-1β transcription and processing in monocytes. Cell Mol Immunol. Nov;13(6):745-763 (Invited to write commentary published in Cell Mol Immunol. 2018 Nov;15(11):998-1000.) (if=7.6, ci=12)

5. Jain M, Singh A, Singh V, Barthwal MK. (2015). Involvement of interleukin-1 receptor-associated kinase-1 in vascular smooth muscle cell proliferation and neointimal formation after rat carotid injury. Arterioscler Thromb Vasc Biol. Jun;35(6):1445-55. (if=6.0, ci=14)

6. Rana M, Reddy SS, Maurya P, Singh V, Chaturvedi S, Kaur K, Agarwal H, Ahmad H, Naqvi A, Dwivedi AK, Dikshit M, Barthwal MK (2015). Turmerone enriched standardized Curcuma longa extract alleviates LPS induced inflammation and cytokine production by regulating TLR4–IRAK1–ROS–MAPK–NFκB axis. J Funct Foods.16,152-163 (if=3.47, ci=11)

7. Singh V, Rana M, Jain M, Singh N, Naqvi A, Malasoni R, Dwivedi AK, Dikshit M, Barthwal MK. (2015). Curcuma oil attenuates accelerated atherosclerosis and macrophage foam-cell formation by modulating genes involved in plaque stability, lipid homeostasis and inflammation. Br J Nutr. Jan;113(1):100-13 (if=3.65, ci=8)

8. Tiwari RL, Singh V, Singh A, Rana M, Verma A, Kothari N, Kohli M, Bogra J, Dikshit M, Barthwal MK. (2014). PKCδ-IRAK1 axis regulates oxidized LDL-induced IL-1β production in monocytes. J Lipid Res. May 2;55(7):1226-1244. (if=4.4, ci=13)

9. Singh V, Jain M, Misra A, Khanna V, Rana M, Prakash P, Malasoni R, Dwivedi AK, Dikshit M, Barthwal MK. (2013). Curcuma oil ameliorates hyperlipidaemia and associated deleterious effects in golden Syrian hamsters. Br J Nutr. Aug 28;110(3):437-46. (if=3.65, ci=18)

10. Tiwari RL, Singh V, Singh A, Barthwal MK. (2011).IL-1R-associated kinase-1 mediates protein kinase Cδ-induced IL-1β production in monocytes. J Immunol. Sep 1;187(5):2632-45. (if=4.92, ci=30)

339

BHADADA, SANJAY KUMAR (b 1968), Professor, Postgraduate Institute of Medical Education and Research,Chandigarh


Dr. Bhadada’s work on bone mineral metabolism in particular primary hyperparathyroidism (PHPT) is innovative, exemplary, and is widely recognized in India and abroad. Because of paucity of data from India, he conceived and established the first online Indian PHPT registry, www.indianphptregistry.com, to better understand epidemiological, clinical, and biochemical characteristics of PHPT in Indians. This online national registry collected data throughout country and shown PHPT in India is still symptomatic. He has extensively studied molecular mechanisms of parathyroid tumorigenesis by genomics (VDR, CaSR, Cyclin D1, and PTH), epigenetics (methylation and acetylation of relevant genes), and proteomics approach. He is currently working on parathyroid cell culture and potential biomarkers for diagnosis and treatment of PHPT and multiple endocrine neoplasia. He has contributed text book chapters and participated in developing international guidelines for managing PHPT. His publications on clinical, biochemical, and localization aspects of PHPT are widely cited in the literature. Additionally, he is also actively working in the field of rare metabolic bone disease, celiac disease as well as in diabetes. Through Chandigarh Bone Epidemiological Study (CUBES) his group is generating normative data for various bone and mineral parameters. He published collaborative research with various national and international institutes speak about his research aptitude and immense net working capacity. His contribution informs of novel treatment for TIO (total parathyroidectomy) and FIO (rhGH) is widely acknowledged. This nomination is to recognize his commitment, achievement and talent in the area of Bone Metabolic Disorders.

Proposer: Dr. Ravinder Goswami, Seconder: Dr. T.R Sharma


1. Bhadada SK, Arya AK, Mukhopadhyay S, Khadgawat R, Sukumar S, Lodha S, Singh DN, Sathya A, Singh P, Bhansali A. Primary hyperparathyroidism: insights from the Indian PHPT registry. J Bone Miner Metab. 2018; 36:238-245. (Corresponding author) (if=2.472, ci=5)

2. Arya AK, Bhadada SK, Singh P, Sachdeva N, Saikia UN, Dahiya D, Behera A, Bhansali A, Rao SD. Promoter hypermethylation inactivates CDKN2A, CDKN2B and RASSF1A genes in sporadic parathyroid adenomas. Sci Rep. 2017; 7:3123. (Corresponding author)(if=4.122, ci=4)

3. Thanseer N, Bhadada SK, Sood A, Mittal BR, Behera A, Gorla AKR, Kalathoorakathu RR, Singh P, Dahiya D, Saikia UN, Rao SD. Comparative Effectiveness of Ultrasonography, 99mTc-Sestamibi, and 18F-Fluorocholine PET/CT in Detecting Parathyroid Adenomas in Patients With Primary Hyperparathyroidism. Clin Nucl Med. 2017;42:e491-e497. (if=6.309, ci=16)

4. Bhadada SK, Varshney S, Saikia UN, Sachdeva N, Behera A, Arya AK, Sharma S, Bhansali A, Mithal A, Rao DS Simultaneous Expression Analysis of Vitamin D Receptor, Calcium Sensing Receptor, Cyclin D1 and PTH in Symptomatic Primary Hyperparathyroidism in Asian Indians. Eur J Endocrinol. 2013 ;169:109-16. (Corresponding author) (if=4.333, ci=22)

5. Bhadada SK, Varshney S, Sachdeva N, Arya AK, Saikia UN, Behera A, Rao SD. Methylation Status of the CpG Islands in Vitamin D and Calcium-Sensing Receptor Gene Promoters Does Not Explain the Reduced Gene Expressions in Parathyroi Adenomas. J Clin Endocrinol Metab. 2013;98:1631-5. (Corresponding author) (if=5.789, ci=19)

6. Bhadada SK, Rastogi A, Steenackers E, Boudin E, Arya A, Dhiman V, Van Hul W. Novel SOST gene mutation in a sclerosteosis patient and her parents. Bone 2012: S8756-3282;1317-8. (Corresponding author) (if=4.455, ci=15)

7. Kumar PR, Bhansali A, Ravikiran M, Bhansali S, Dutta P, Thakur JS, Sachdeva N, Bhadada S, Walia R. Utility of glycated hemoglobin in diagnosing type 2 diabetes mellitus: a community-based study. J Clin Endocrinol Metab 2010;95:2832-5.9. (if=5.789, ci=76)

8. Bhadada S K, Bhansali A, Ahluwalia J, GV Chanukya, Behera A, Dutta P. Anaemia and marrow fibrosis in patients with primary hyperparathyroidism before and after curative parathyroidectomy. Clinical Endocrinology 2009;70:527-532. (if=3.077, ci=17)

9. Bhadada S K, Bhansali A, Kochhar R etal. Does every short stature child need screening for celiac disease?. Journal of Gastroenterology & Hepatology 2008; 23:353-6. (if=3.483, ci=21)

10. Bhadada SK, Udawat HP, Bhansali A, Rana SS, Sinha SK and Bhasin DK. Chronic pancreatitis in primary hyperparathyroidism: comparison with alcoholic and idiopathic chronic pancreatitis. Journal of Gastroenterology and Hepatology,2008;23:959-64. (if=3.483, ci=21)

340

CHANDRA, AMAR KUMAR (b 1951), UGC Emeritus Fellow/ Ex Professor, Department of Physiology, University of Calcutta, Kolkata


Dr. Amar K Chandra is an eminent Professor and investigator in thyroid and reproductive endocrinology. His epidemiological studies on iodine nutrition during post-salt iodization phase in northeast, sub-Himalayan-tarai region, delta and coastal areas of Gangetic West Bengal and Kolkata, reveals endemic goiter that still persists moderately not for inadequate iodine intake but for consumption of foods containing cyanogenic glycosides, flavonoids and iodine in excess; in vivo and in vitro studies with thyroid of man and animals goitrogenic/antithyroidal potential of those dietary constituents has established. Molecular mechanism of those Indian plant-foods extracts, calcium and perchlorate on thyroid cells at cellular and molecular levels on thyroid hormone synthesizing regulatory elements, ROS generation, cell cycle analysis, and H2O2 assay studied and postulated the signaling pathway for action. Also studied the adverse effect of several environmental contaminants on male reproduction with possible prevention by natural antioxidants following in vivo and in vitro studies; excess iodine on reproduction, brain and immune system inferring the occurrence of reproductive infertility, neuro-degeneration and immune suppression. He showed improper iodine supplementation in iodine replete environment and classical iodine deficient areas develops autoimmune thyroiditis. He published more than 89 original articles in peer reviewed journals, completed 18 projects and supervised 24 PhDs. For significant contribution in the advancement of Medical Sciences he elected Fellow, National Academy of Medical Sciences, India (FAMS) and UGC Emeritus Professor. His current research interest is on epigenetics related to autoimmune thyroiditis. Besides academic attainment Dr. Chandra is President-PSI, General Secretary-FIPS, Secretary General-SAAP, Executive Editor- IJPAS.

Proposer: Prof. Atanu Kumar Pati, Seconder: Prof. Umesh Rai


1. Chandra AK, Mukhopadhyay S, Lahari D and Tripathy S (2004): Goitrogenic content of cyanogenic plant foods of Indian origin & their in vitro anti-thyroidal activity. Indian J Med Res.119:180-185. (if=2.06, ci=51)

2. Chandra AK, Tripathy S, Ghosh D, Debnath A and Mukhopadhyay S (2005): Iodine nutritional status & prevalence of goitre in Sundarban delta of South 24- Parganas, West Bengal, Indian J Med Res.122 (5): 419-424 (if=2.06, ci=25)

3. Chandra AK, Ghosh R, Chatterjee A, Sarkar M (2007): Effects of vanadate on male rat reproductive tract histology, oxidative stress markers and androgenic enzyme activities. J Inorg Biochem. 101(6): 944-956 . (if=3.348, ci=34)

4. Chandra AK, Chatterjee A, Ghosh R, Sarkar M, Chaube SK (2007): Chromium induced testicular impairment in relation to adrenocortical activities in adult albino rats. Reproductive Toxicol. 24(3-4):388-96. (if=2.850, ci=26)

5. Chandra AK, Chatterjee A, Ghosh R, Sarkar M (2007): Effect of curcumin on chromium induced oxidative damage in male reproductive system, Environ Toxicol Phar. 24: 160–166. (if=2.776, ci=25)

6. Chandra AK, Ghosh R, Chatterjee A, Sarkar M (2007): Amelioration of vanadium induced testicular toxicity and adrenocortical hyperactivity by vitamin E acetate in rats. Mol Cell Biochem, 306 (1-2): 189-200. (if=2.561, ci=24)

7. Chandra AK, Chatterjee A, Ghosh R, Sarkar M (2010): Vitamin E-supplementation protect chromium (VI)-induced spermatogenic and steroidogenic disorders in testicular tissues of rats. Food Chem Toxicol. 48: 972–979. (if=3.8, ci=32)

8. Chandra AK, N De (2010): Goitrogenic/antithyroidal potential of green tea extract in relation to catechin in rats. Food Chem Toxicol. 48: 2304-2311. (if=3.8, ci=29)

9. Chandra AK, Sengupta P, Goswami H and Sarkar M (2012): Excessive dietary calcium in the disruption of structural and functional status of adult male reproductive system in rat with possible mechanism. Mol Cell Biochem. 364 (1-2): 181-191. (if=2.561, ci=21)

10. Chandra AK, Sengupta P, Goswami H and Sarkar M (2013): Effects of dietary magnesium on testicular histology, steroidogenesis, spermatogenesis and oxidative stress markers in adult rats. Indian J Exp Biol. 51(1): 37-47 (if=1.475, ci=28)

341

CHILAKAPATI, MURALI KRISHNA (b 1967), Principal Investigator and Scientific Officer F, Advanced Center for Research, Treatment and Education in Cancer (ACTREC), Navi Mumbai


Dr. Krishna is conducting extensive Raman spectroscopy clinical trials, in vivo and body-fluids/exfoliated cells, for cancer and other disease diagnosis, screening and therapeutic-monitoring. He was first to demonstrate Raman in vivo spectra of oral cancer subjects, in clinically-implementable time, subsequently delineation of oral malignant, premalignant subjects and most importantly cancer-field-effects, the earliest events in oral cancers. His studies ruled out influence of age-related-physiological changes on Raman-based-cancer diagnosis/screening. He successfully shown, oral cavity can be treated as single entity simplifying screening. His cervical cancer clinical trials demonstrated suitability of vagina as internal-control which is very significant for noninvasive Raman-screening applications. His serum-Raman trails demonstrated oral cancer screening with comparable sensitivity/specificity to conventional screening tools- mammography, Pap. Raman-exfoliative-cytology trials of cerival and oral have yielded acceptable sensitivity/specificity. He has successfully explored in vivo and ex vivo approaches in predicting recurrences and secondary primaries, known hurdles and attributed to poor prognosis in oral cancers. His studies suggest utility of serum Raman in diagnosis of asthma, meningioma, malaria and dengue subjects and monitoring therapeutic drug levels of Imatinib, a known drug for CML. Drug and radiation resistance in cell lines/ex vivo samples is also reported by him. He is a BOYSCAST Fellow and regular visiting scientist/professor, Univerisity of Reims, France. 10 students have graduated under him. He authored papers-114 (h-index-30, i10-54) reviews/book chapters-12 and books-1. He successfully pursuing/completed several government funded projects and participating international collaborations (National Translational Research, NCI, NIH, USA, European Union programs, Indo-Finnish, DBT, Indo-Mexican DST).

Proposer: Dr. G. Bhanuprakash Reddy, Seconder: Dr. Kamala Krishnaswamy


1. Kanika Mehta, Apurva Atak, Aditi Sahu, Sanjeeva Srivastava and Murali Krishna C, 2018, An early investigative serum Raman spectroscopy study of meningioma, Analyst,. 10.1039/C8AN00224J (if=3.864, ci=1)

2. Malik Akshat, Sahu Aditi, Singh Surya, Deshmukh Atul, Nair, Deepa, Nair Sudhir Chatturvedi Pankaj, C. Murali Krishna, 2017, In vivo Raman spectroscopic early identification of potential secondary tumors/recurrences in oral cancers: An exploratory (if=2.417, ci=6)

3. Murali Krishna C, Aditi Sahu, 2017 Water concentration analysis of the surgical margin - letter, Cancer Research, 10.1158/0008-5472.CAN-16-3206 (if=9.130)

4. Aditi Sahu Venkatesh Pai Poonam Gera Abhishek Dubey, Gunjan Tyagi Manoj Mahimkar Murali Krishna C, 2017, Raman exfoliative cytology for oral pre-cancer diagnosis, Journal of Biomedical Optics. 22 (11), 115003, 10.1117/1.JBO.22.11.115003 (if=2.367, ci=4)

5. Ekjot Kaur, Aditi Sahu, Jacinth Rajendra, Rohan Chaubal, Nilesh Gardi, Aliasgar Moiyadi, C. Murali Krishna, Shilpee Dutt, 2016, Unique spectral markers discern recurrent glioblastoma cells from heterogeneous parent population, Scientific Repor (if=4.259, ci=5)

6. A. Sahu, Nikhila, S. Sawant and C. Murali Krishna, 2015, Recurrence prediction in oral cancers: a serum Raman spectroscopy study, Analyst 140, 2294 – 2301, 10.1039/C4AN01860E. (if=4.033, ci=30)

7. Rubina S, Priyanka Sathe, Tapas Kumar Dora, Supriya Chopra, Amita Maheshwari, C. Murali Krishna, 2014, In vivo Raman spectroscopy of human uterine cervix: Exploration of internal control, Journal of Biomedical Optics,19 (8), 087001. 10.1117/1.JBO.(if=2.859, ci=15)

8. S.P. Singh, Atul Deshmukh, Pankaj Chaturvedi, Murali Krishna C, 2013, In vivo Raman spectroscopy of oral buccal mucosa: A study on malignancy associated changes (MAC)/cancer field effects (CFE), Analyst, 138 (14), 4175 - 4182. c3an36761d (if=3.906, ci=64)

9. S. Rubina, Maheswari Amita, Deodhar Kedar K., Rekhi Bharat, C. Murali Krishna Raman spectroscopic classification of cervical cell specimen, Vibrational Spectroscopy 68, 115–121, 2013. 10.1016/j.vibspec.2013.06.002 (if=1.79, ci=28)

10. C. Murali Krishna, G. Kegelaer, I. Adt, S. Rubin, V.B. Kartha, M. Manfait and G.D. Sockalingum, 2005, Characterisation of uterine sarcoma cell lines exhibiting MDR phenotype by vibrational spectroscopy Biochimica et Biophysica Acta (BBA) - Gener (if=3.5, ci=31)

342

DAS, SUJATA (b 1970), Consultant (Cornea Service), and Medical Director, Drushti Daan Eye Bank, L V Prasad Eye Institute, Patia, Bhubaneswar, Odisha, 751024.


The work of Sujata Das on microsporidial keratitis has dominated the existing knowledge on parasitic-ocular-infections. Epidemic keratoconjunctivitis (EKC), occurs worldwide, is infectious and often seasonal, and is invariably considered to have a viral etiology (adenovirus/enterovirus). Causes other than viral have never been considered. Das et al were the first-to-report a seasonal-outbreak of EKC caused by microsporidial infection of the cornea. On contrary to the belief that EKC involves immunocompromised patients, Das et al have shown EKC is increasingly prevalent in immunocompetent patients. Her research has established the co-existence of microsporidia and adenovirus for the first-time. Anecdotal reports on the management of microsporidial keratoconjunctivitis include the use of various drugs. Das et al conducted a RCT and concluded that microsporidial infection is self-limiting in nature. Although uncommon, Das et al have reported for the first-time a rare-case of microsporidial-stromal-keratitis with intraocular invasion by microsporidial spores. Das et al have reported diagnosis, clinical features, and treatment outcome of microsporidial keratoconjunctivitis involving one of the largest-series of patients. On the contrary to the belief that surgical-intervention may help in faster clinical resolution by decreasing the microbial-load in the corneal epithelium, Das et al, through a RCT, proved that debridement does not have any significant advantage in terms of resolution of the corneal lesions and final visual outcome in cases of microsporidial keratoconjunctivitis. Sujata Das was also associated in a major survey article and a book chapter that presented the biology, phylogeny, classification, disease profile, diagnosis, and treatment of microsporidia in ocular infections.

Proposer: Gullapalli N Rao, Seconder: Prof. Dorairajan Balasubramanian


1. Sharma S, Sahu SK, Dhillon V, Das S, Rath S (2015). Reevaluating intracameral cefuroxime as prophylaxis against endophthalmitis after cataract surgery in India. J Cataract Refract Surg; 41(2): 393-399. (if=2.680 (2017), ci=48)

2. Basu S, Fernandez MM, Das S, Gaddipati S, Vemuganti GK, Sangwan VS (2012). Clinical outcomes of xeno-free allogeneic cultivated limbal epithelial transplantation for bilateral limbal stem cell deficiency. Br J Ophthalmol; 96(12):1504-1509. (if=3.384 (2017), ci=46)

3. Sharma S, Das S, Joseph J, Vemuganti GK, Murthy S (2011). Microsporidial keratitis: need for increased awareness. Surv Ophthalmol; 56(1): 1-22. (if=3.764 (2017), ci=51)

4. Rautaraya B, Sharma S, Kar S, Das S, Sahu SK (2011). Diagnosis and Treatment Outcome of Mycotic Keratitis at a Tertiary Eye Care Center in Eastern India. BMC Ophthalmol; 11(1): 39. (if=1.819 (2017), ci=72)

5. Das S, Seitz B (2008). Recurrent corneal erosion syndrome. Surv Ophthalmol; 53(1): 3-15. (if=3.764 (2017), ci=83)

6. Das S, Sharma S, Sahu SK, Nayak SS, Kar S (2008). New microbial spectrum of epidemic keratoconjunctivitis: clinical and laboratory aspects of an outbreak. Br J Ophthalmol; 92(6): 861-862. (if=3.384 (2017), ci=41)

7. Das S, Sheorey H, Taylor HR, Vajpayee RB (2007). Association between cultures of contact lens and corneal scraping in contact lens related microbial keratitis. Arch Ophthalmol; 125(9): 1182-1185. (if=6.669 (2017), ci=53)

8. Das S, Link B, Seitz B (2005). Salzmann’s nodular degeneration of the cornea: a review and case series. Cornea; 24(7): 772-777.(if=2.464 (2017), ci=53)

9. Das S, Langenbucher A, Pogorelov P, Link B, Seitz B (2005). Long-term outcome of excimer laser phototherapeutic keratectomy for treatment of Salzmann’s nodular degeneration. J Cataract Refract Surg; 31(7): 1386-1391. (if=2.680 (2017), ci=39)

10. Das S, Langenbucher A, Seitz B (2005). Excimer laser phototherapeutic keratectomy for granular and lattice dystrophy - a comparative study. J Refract Surg; 21(6): 727-731. (if=2.649 (2017), ci=37)

343

DUTTA, SHANTA (b 1962), Director & Scientist-G, Icmr-National Institute of Cholera and Enteric Diseases, Kolkata


Dr. Shanta Dutta has 25 years of research experience in the field of enteric/ diarrheal diseases and her research focused on both applied and basic aspects involving enteric pathogens like Shigella, Salmonella, Vibrio species; in which she has made significant contributions. Her work on PCR based detection of Shigella in clinical samples reported three fold higher rate of detection of shigellosis cases in comparison to the conventional method. This led to her investigation of a localized dysentery outbreak in Kolkata caused by Sh. dysentery Type 1 with epidemic potential. She is actively involved in the development of more sensitive PCR based and specific typhoid diagnostic kit and post marketing monitoring of the existing diagnostics. Her investigation on the molecular characterization of Shigella and Salmonella strains w.r.t. their antimicrobial resistance, their mechanism, virulence markers and molecular subtypes has led to better understanding of the molecular epidemiology of these organisms and formulation of better treatment and control strategies. In typhoid Vi vaccine trial, she was the only laboratory investigator and extended the molecular subtyping to the study strains. Besides, in search of alternative remedies for typhoid she explored anti-typhoid activity of medicinal plant extracts, practiced by some tribal healers and documented some traditional preparations. She is an invited article-reviewer for national/ international journals and project-reviewer for funding agencies, has published >100 original and review articles. Her work was recognized by conferring her DST-RONPAKU Fellowship, fellowship of West Bengal Academy of Science & Technology, Membership of National academy of Medical Sciences etc.

Proposer: Dr. Amit Ghosh, Seconder: Dr. Manoj Kumar Chakrabarti


1. Dutta S, Chatterjee A, Dutta P, Rajendran K, Pramanik KC, Bhattacharya SK. 2001. Sensitivity and performance characteristics of a PCR diagnostic system in comparison to conventional techniques for detection of Shigella and enteroinvasive E. coli in stool samples from children with acute diarrhoea in Calcutta, India. J Med Microbiol. 50: 667-74 (if=2.112 (2017), ci=108)

2. Dutta S, Rajendran K, Roy S, Chatterjee A, Dutta P, Nair GB, Bhattacharya SK, Yoshida S-I. 2002. Shifting serotypes, plasmid profile analysis and antimicrobial resistance pattern of shigellae strains isolated from Kolkata, India during 1995- 2000. Epidemiol Infect. 129(2):235-43 (if=2.044 (2017), ci=75)

3. Dutta S, Dutta D, Dutta P, Matsushita S, Bhattacharya SK, Yoshida S-I. 2003 Shigella dysenteriea serotype 1, Kolkata, India. Emerg Infect Dis. 9(11):1471-74 (if=7.42 (2017), ci=63)

4. Dutta S, Kawamura Y, Ezaki T, Nair GB, Iida Ken-Ichiro Yoshida S-I. 2005. Alteration in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV in Quinolone Resistant Shigella dysenteriae serotype 1 clinical isolates from Kolkata, India. Antimicrob Agents Chemother. 49(4):1660-61 (if=4.476, ci=52)

5. Dutta S, Sur D, Manna B, Sen B, Deb AK, Deen JL, Wain J, Von Seidlein L, Ochiai L, Clemens JD, Kumar Bhattacharya S. 2006. Evaluation of new-generation serologic tests for the diagnosis of typhoid fever: data from a community-based surveillance in Calcutta, India. Diagn Microbiol Infect Dis. 56(4):359-65 (if=2.341 (2017), ci=75)

6. Kanungo S, Dutta S, Sur D. 2008. Epidemiology of typhoid and paratyphoid fever in India. J Infect Dev Ctries. 2(6):454-60 (if=1.353 (2017), ci=73)

7. Holt KH, Dutta S, Manna B, Bhattacharya SK, Bhaduri B, Pickerd D, Ochiai RL, Ali M, Clemens JD, Dougan G. 2012. High resolution genotyping of the endemic Salmonella Typhi population during Vi vaccination trial in Kolkata. PLoS Negl Trop Dis. 6(1):e1490 (if=4.367 (2017), ci=17)

8. Dutta S, Das S, Mitra U, Jain P, Roy I, Ganguly SS, Ray U, Dutta P, Paul DK. 2014 Antimicrobial Resistance, Virulence Profiles and Molecular Subtypes of Salmonella enterica Serovars Typhi and Paratyphi A Blood Isolates from Kolkata, India during 2009-2013. PLoS One. 9(8):e101347 (if=2.766 (2017), ci=53)

9. Howlader DR, Koley H, Maiti S, Bhaumik U, Mukherjee P, Dutta S. 2017. Brief review on the immunological scenario and recent developmental status of vaccines against enteric fever. Vaccine. 35(47): 6359-66 (if=3.285 (2017), ci=1)

10. Chattopadhyay D, Ojha D, Mukherjee H, Bag P, Vaidya SP, Dutta S. 2018. Validation of a traditional preparation against multi-drug resistant Salmonella Typhi and its protective efficacy in S. Typhimurium infected mice. Biomed Pharmacother. 99: 286-89 (if=3.457 (2017), ci=2)

344

GOEL, RAJESH KUMAR (b 1972), Dean, Faculty of Medicine, Punjabi University, Patiala


In the area of epileptology, Prof Goel set the trend to use kindled animals for studying epilepsy associated psychiatric and cognitive comorbidities. He has used this approach to understand different pharmacological targets for amelioration of epilepsy associated memory deficit and Depression. He explored non chemotherapeutic application of monocyclic beta lactams. It gives me pride to say that this was first study conducted, which explored antidiabetic, anxiolytic antihyperlipidemic activities of beta lactams. Professor R K Goel has a lot of experience in investigating the role of different targets for management of Psychopharmacological diseases e.g. Epilepsy, Depression, memory deficit, Anxiety and metabolic disorders Like diabetes,Hyperlipdemia. [Neurochem Int. 2017;104:27-33.,Epilepsy Behavior 201766;93-99, Pharmacological Reports 69 ;143-149.,Epilepsy & Behavior 2017 66; Neurochemistry International (2016 Neuroscience 339.] His interest in in-silico based prediction and evaluation of synthetic moieties resulted in non antibiotic uses of monocyclic beta lactams [(2008) Bioorganic and Medicinal Chemistry Letters 18, (2007) Bioorganic and Medicinal Chemistry Letters 17, (2005). Bioorganic and Medicinal Chemistry Letters 15,. (2005). Die Pharmazie 60, 369-374. ,(2005) Journal of Pharmacy and Pharmaceutical Sciences 8, 182-189., (2004) Journal of Pharmacy and Pharmaceutical Sciences 7, 80-83. (2004) Indian Journal of Pharmaceutical Sciences 66, 87-91.] He also has wide experience of evaluating Phytomolecules and plants for many activities even tried to pin point the variabilities of probable active phytoconstituents responsible for tested biological activities[2018 JPC-Journal of Planar Chromatography-Modern TLC. Aug;31 2018 J Natural product research. an 14:1-7. 2017 Neurochem Int.Mar;104:27-33, 2016 Chemico-Biological Interactions 260, 208-218, 2017 Biomed Pharmacother. Aug;92:720-725.].

Proposer: Prof. R.K. Goyal, Seconder: Prof. Garikapati Narahari Sastry


1. Singh, Damanpreet; Singh, Bikram; Goel, Rajesh Kumar; Traditional uses, phytochemistry and pharmacology of Ficus religiosa: a review Journal of ethnopharmacology 134 3 565-583 2011 (if=3.2, ci=130)

2. Goel, Rajesh K; Mahajan, Mohinder P; Kulkarni, Shrinivas K; Evaluation of anti-hyperglycemic activity of some novel monocyclic beta lactams J Pharm Pharm Sci 7 1 80-83 2004 (if=2.4, ci=83)

3. Singh, Damanpreet; Goel, Rajesh Kumar; Anticonvulsant effect of Ficus religiosa: role of serotonergic pathways Journal of ethnopharmacology 123 2 330-334 2009 (if=3.2, ci=97)

4. Singh, Damanpreet; Singh, Bikram; Goel, Rajesh Kumar; Traditional uses, phytochemistry and pharmacology of Ficus religiosa: a review Journal of ethnopharmacology 134 3 565-583 2011 (if=3.2, ci=130)

5. Lagunin, Alexey A; Goel, Rajesh K; Gawande, Dinesh Y; Pahwa, Priynka; Gloriozova, Tatyana A; Dmitriev, Alexander V; Ivanov, Sergey M; Rudik, Anastassia V; Konova, Varvara I; Pogodin, Pavel V; Chemo-and bioinformatics resources for in silico drug discovery from medicinal plants beyond their traditional use: a critical review Natural product reports (if=11.5, ci=54)

6. Singh, Damanpreet; Mishra, Awanish; Goel, Rajesh Kumar; Effect of saponin fraction from< i> Ficus religiosa on memory deficit, and behavioral and biochemical impairments in pentylenetetrazol kindled mice Epilepsy & Behavior 27 1 Pages 206–211 2013 (if=2.1, ci=37)

7. Goel, Rajesh Kumar; Singh, Damanpreet; Lagunin, Alexey; Poroikov, Vladimir; PASS-assisted exploration of new therapeutic potential of natural products Medicinal Chemistry Research 20 9 1509-1514 2011 (if=1.7, ci=76)

8. Khurana, Navneet; Ishar, Mohan Pal Singh; Gajbhiye, Asmita; Goel, Rajesh Kumar; PASS assisted prediction and pharmacological evaluation of novel nicotinic analogs for nootropic activity in mice European journal of pharmacology 662 1-3 22-30 2011 (if=3, ci=46)

9. Murtazalieva, KA; Druzhilovskiy, DS; Goel, RK; Sastry, GN; Poroikov, VV; How good are publicly available web services that predict bioactivity profiles for drug repurposing? SAR and QSAR in Environmental Research 28 10 843-862 2017 (if=2.3, ci=16)

10. Singh, Bhupinder; Singh, Damanpreet; Goel, Rajesh Kumar; Dual protective effect of< i> Passiflora incarnata in epilepsy and associated post-ictal depression Journal of Ethnopharmacology 2011 (if=3.2, ci=47)

345

GUPTA, RITU (b 1972), Professor & Officer-in-Charge, Laboratory Oncology Unit, AIIMS, New Delhi


Dr Ritu Gupta joined as faculty at AIIMS, New Delhi in 2005. Dr Ritu Gupta has strived to establish state of art diagnostic and research facilities in the domain of Haemato-Oncology. Using high-end genomics, she has profiled the epigenome of Chronic lymphocytic leukemia (CLL) and identified key genes responsible for disease progression in this relatively indolent neoplasm (PMID: 28572861). Recently, she has finished analysis of miRnome in CLL and identified key miRNA responsible for disease progression and outcome in CLL. To further the understanding of factors responsible for aggressive clinical course in CLL, she established the IGHV mutation analysis in conjunction with other laboratory and molecular parameters (PMID: 30338367; 26942309; 24656596). A major focus of her research laboratory is multiple myeloma (MM) and she has established a Unit of Excellence in MM at AIIMS with financial support from DBT. Besides the evaluation of global genetic events such as chromothripsis (PMID: 30576858), her lab has also established a new algorithm for implementation of Revised International Staging System (RISS) for MM (PMID: 30056581). She has also contributed to the understanding of tumour microenvironment including angiogenesis and functional T-cell repertoire in MM (PMID: 23332455; 23113684; 21973309; 22045305; 21146215). Dr Ritu Gupta has established multi-parametric flow cytometry based minimal residual disease evaluation (MRD) in hematolymphoid malignancies (PMID: 1984681; 15023041) and is currently engaged in developing machine learning based tool for monitoring MRD in collaboration with IIITD (Indian Patent Application No.: 201611031953).

Proposer: Prof. Chitra Sarkar, Seconder: Prof. Lalit Kumar


1. Rani L, Mathur N, Gupta R*, Gogia A, Kaur G, Dhanjal JK, Sundar D, Kumar L, Sharma A. Genome-wide DNA methylation profiling integrated with gene expression profiling identifies PAX9 as a novel prognostic marker in chronic lymphocytic leukemia. Clin Epigenetics. 2017;9:57. doi: 10.1186/s13148-017-0356-0. (PMID:28572861) (if=6.091, ci=4)

2. Rani L, Mathur N, Gogia A, Vishnubhatla S, Kumar L, Sharma A, Dubey D, Kaur P, Gupta R*. Immunoglobulin Heavy Chain Variable Region Gene Repertoire and B-Cell Receptor Stereotypes in Indian Patients with Chronic Lymphocytic Leukemia. Leuk Lymphoma 2016;57(10):2389-400(PMID:26942309) (if=2.644, ci=3)

3. Kumar L, Iqbal N, Mookerjee A, Verma RK, Sharma OD, Batra A, Pramanik R, Gupta R. Complete response after autologous stem cell transplant in multiple myeloma. Cancer Med. 2014; 3:939-46. (PMID: 24777883) (if=3.202, ci=16)

4. Bhaskar A, Gupta R*, Sreenivas V, Kumar L, Sharma A, Sharma MC, Prasenjit Das P, Thakur SC. Angiopoietins as biomarker of disease activity and response to therapy in multiple myeloma. Leuk Lymphoma. 2013; 54:1473-8 (PMID: 23113684) (if=2.644, ci=15)

5. Bhaskar A, Gupta R*, Sreenivas V, Rani L, Kumar L, Sharma A, Sharma OD, Sharma MC, Thakur SC. Synergistic effect of vascular endothelial growth factor and angiopoietin-2 on progression free survival in multiple myeloma. Leuk Res. 2013; 37:410-415 (PMID: 23332455) (if=2.4, ci=13)

6. Bhaskar A, Gupta R*, Kumar L, Sharma A, Sharma MC, Kalaivani M, Thakur SC. Circulating endothelial progenitor cells as potential prognostic biomarker in multiple myeloma. Leuk Lymphoma. 2012; 53:635-40. (PMID: 21973309) (if=2.644, ci=22)

7. Gupta R*, Ganeshan P, Hakim M, Verma R, Sharma A, Kumar L. Significantly reduced regulatory T cell population in patients with untreated multiple myeloma. Leukemia Research 2011;35: 874-878 (PMID: 21146215) (if=2.4, ci=51)

8. Gupta R*, Bhaskar A, Kumar L, Sharma A, Jain P. Flow cytometric immunophenotyping and minimal residual disease analysis in multiple myeloma. Am J Clin Pathol 2009;132:728-732 (PMID: 19846814) (if=2.4, ci=63)

9. Gupta R, Jain P, Deo SVS, Sharma A. Flow cytometric analysis of CD5 positive B-cells- a frame of reference for minimal residual disease in Chronic lymphocytic leukemia. Am. J Clin Path. 2004; 121:368-372 (PMID: 15023041) (if=2.4, ci=18)

10. Jain P, Kumar R, Anand M, Asthana S, Deo SVS, Gupta R, Bhutani M, Karak AK, Shukla NK. Touch imprint cytology of axillary lymph nodes after neoadjuvant chemotherapy in patients with breast cancer. Cancer 2003; 99:346-351 (PMID: 14681942) (if=6.537, ci=21)

346

GUTTI, RAVI KUMAR (b 1974), Professor, Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad


The nominee, Ravi Gutti is an established investigator in the area of biomedical science. Dr. Gutti’s work on post-transcriptional regulators (miRNAs) contributing to the developmental differences between neonates and adults is bringing a paradigm shift in our understanding of neonatal thrombocytopenia (low platelets), with clear insights into the molecular regulation of megakaryocytopoiesis. Thrombocytopenia, a low platelet disorder, is common (~50%) among neonates admitted to Neonatal Intensive Care Unit. The causes for the predisposition of neonates to develop thrombocytopenia is unclear. His research is focused on understanding the developmental differences in miRNA mediated post-transcriptional regulation between neonates and adults. The outcomes of his research will help in disease understanding, with clear insights into the molecular regulation of megakaryocytopoiesis. For the first time, his studies showed the inhibitory effect of let-7b on wnt signaling pathway through Fzd4 axis, and thereby regulating proliferation as well as differentiation during megakaryocyte development. His studies also highlighted the functional significance of miR-9 in cell proliferation by targeting RUNX1 and CXCR4, which are essential for polyploidization and cytoskeleton rearrangement in megakaryocyte maturation. His group aim is to provide neonatologists, who are frequently confronted with the issue of severe thrombocytopenia, with clear insights into the molecular regulation of megakaryocytopoiesis by elucidating the role of miRNA in developmental megakaryocytopoiesis.

Proposer: Prof. Appa Rao Podile, Seconder: Prof. Aparna Dutta Gupta


1. Sahu I, Hebalkar R, Kar S, SreeVidya T, Gutti U, Gutti RK.Systems biology approach to study the role of miRNA in promoter targeting during megakaryopoiesis. Exp. Cell Res. 2018 May 15;366(2):192-198. (if=3.546)

2. Raghuwanshi S, Gutti U, Kandi R, Gutti RK. MicroRNA-9 promotes cell proliferation by regulating RUNX1 expression in human megakaryocyte development. Cell Prolif. 2018 Feb;51(1). (if=4.936)

3. Al-Maghout T, Pelzl L, Sahu I, Sukkar B, Zohreh H, Gutti R, Laufer S, Voelkle J, Pieske B, Gawaz M, Lang F. P38 Kinase, SGK1 and NF-κB Dependent Up-Regulation of Na+/Ca2+ Exchanger Expression and Activity Following TGFß1 Treatment of Megakaryocytes (if=5.104)

4. Sahu I, Pelzl L, Sukkar B, Fakhri H, Al-Maghout T, Cao H, Hauser S, Gutti R, Gawaz M, Lang F. NFAT5-sensitive Orai1 expression and store-operated Ca2+ entry in megakaryocytes. FASEB J. 2017, 31(8):3439-3448 (if=5.498)

5. Undi RB, Gutti U, Gutti RK. LiCl regulates mitochondrial biogenesis during megkaryocyte development. J Trace Elem Med Biol. 39 (2017) 193-201. (if=3.225)

6. Undi RB, Gutti U, Gutti RK. Role of Let-7b/Fzd4 Axis in Mitochondrial Biogenesis through Wnt Signaling: In Neonatal and Adult Megakaryocytes. Int J Biochem Cell Biol. 2016 Aug 7;79:61-68. (if=4.25)

7. Undi R, Sarvothaman S, Kovuru N, Gutti U, Gutti RK. Toll-like Receptor 2 Signalling: Significance in Megakaryocyte Development through Wnt Signalling Cross-talk and Cytokine Induction. Cytokine 2016 Jul;83:245-9. (if=3.488)

8. Kandi R, Gutti U, Undi R, Sahu I, Gutti RK. Understanding Thrombocytopenia: Physiological Role of microRNA in Survival of Neonatal Megakaryocytes. J Thromb Thrombolysis. 2015 Oct;40(3):310-6. (if=2.620)

9. Ferrer-Marin, F, Gutti R, Liu Z-J, Sola-Visner M. MiR-9 Contributes to the developmental differences in CXCR-4 expression in human megakaryocytes. (2014) J. of Thrombosis and Haemostasis 12: 282-285. (if=6.08)

10. Kandi R, Undi R, Gutti RK. MiR-125b regulates cell proliferation and survival in neonatal megakaryocytes. Ann Hematol. 2014 Jun;93(6):1065-6. (if=2.845)

347

JAIN, AMITA (b 1960), Professor and Head, Department of Microbiology, King George’s Medical University, UP, Lucknow


Prof. Amita Jain, (MD, PhD, FAMS, FRCPath), is involved in diagnosis, outbreak investigation, research and training in field of Virology and tuberculosis, with capacity of diagnosing more than 43 human pathogenic viruses by serological, molecular, sequencing and viral culture methods. She invented novel methods for detection of Hepatitis viruses, Herpes viruses and Parvovirus 4 and filed patents for the same. She executed large scale studies related to drug resistance in Tuberculosis using advanced methods like sequencing. Her studies focus on epidemiology, mechanisms of emergence/ development and transmission of drug resistance, evaluation and invention of cost effective phenotypic and genotypic methods for diagnosis, detection of drug resistance and looking at treatment options (adjuvant therapy). She published first report on XDR and Pre-XDR Tuberculosis from India. She executed several large multicentric studies on drug resistance in other pathogens like Pneumococci, H. influenza, Staphylococci etc. She has established and serves as officer in charge of Virus research and diagnostic laboratory of Indian Council of Medical Research and Intermediate Reference tuberculosis laboratory, Revised National Tuberculosis Control Program, at Department of Microbiology, King George’s Medical University, Lucknow, UP. She has published two books, total 253 indexed publications (217 Research articles, 23 reviews, 5 book chapters, 8 case reports) and 1346 nucleotide sequences, with total author citations of 4431, H index of 35 and i10 index of 96. She has successfully completed 30 research projects and is guiding 9 projects currently. She has guided 122 MD/ MS/ MDS/ DM/ MCH students and 27 Ph. D. students.

Proposer: Dr. Yogendra Sharma, Seconder: Dr. Kandala Venkata Ramana Chary


1. Roy I, Jain A, Kumar M, Agarwal SK. Bacteriologe of neonatal septicaemia in a tertiary care hospital of northern India. Indian Journal of Medical Microbiology. 2002 Jul 1;20(3):156. (if=1.008, ci=138 )

2. Amita Jain, Indranil Roy, Mahendra K Gupta, Mala Kumar, S. K. Agarwal 2003. Prevalence of extended spectrum beta lactamase producing gram negative bacteria in septicaemic neonates in a tertiary care hospital. Journal of Medical Microbiology 52 421-425(if=2.380, ci=258)

3. Jain A, Basal E. 2003, Inhibition of Propionibacterium acnes-induced mediators of inflammation by Indian herbs. Phytomedicine;10(1):34-8. (if=3.327, ci=138)

4. Basal E, Jain A, Kaushal GP. 2004, Antibody response to crude cell lysate of propionibacterium acnes and induction of pro-inflammatory cytokines in patients with acne and normal healthy subjects. Journal of Microbiology: 42(2):117-25. (if=1.529, ci=49)

5. Amita Jain, Pradeep Kumar, Shally Awasthi, 2005. High nasopharyngeal carriage of drug resistant Streptococcus pneumoniae and Haemophilus influenzae in school going North Indian children. Tropical Medicine and International health 10 (3): 234-239 (if=2.953, ci=78)

6. Amita Jain, Rajesh Mondal 2007. Prevalence and antimicrobial resistance pattern of extended spectrum β-lactamase producing Klebsiella spp isolated from cases of neonatal septicaemia. Indian Journal of Medical Research 125(1):89-94, (if=1.883, ci=69)

7. Rajesh Mondal and Amita Jain, 2007, Extensively drug resistant Mycobacterium tuberculosis, India. Emerging Infectious Diseases 13 (9):1429–143 (if=6.794 , ci=53)

8. Amita Jain, Astha Agarwal 2008, Biofilm production, a marker of pathogenic potential of colonizing and commensal staphylococci. Journal of Microbiological Methods 76: 88-9 (if=2.47, ci=159)

9. Jain A, Agarwal A, 2008, Verma RK. Cefoxitin disc diffusion test for detection of meticillin-resistant staphylococci. Journal of medical microbiology;57(8):957-61. (if=2.380, ci=55)

10. Jain P, Prakash S, Gupta S, Singh KP, Shrivastava S, Singh DD, Singh J, Jain A. 2013 Prevalence of hepatitis A virus, hepatitis B virus, hepatitis C virus, hepatitis D virus and hepatitis E virus as causes of acute viral hepatitis in North India: hospital based study. Indian journal of Medical Microbiology;31(3):261. (if=0.8, ci=53)

348

KANT, RAVI (b 1956) Director & CEO, All India Institute of Medical Science, Rishikesh


Presently Director, AIIMS Rishikesh. Earlier, Vice Chancellor, KGMU Lucknow. Member of Faculty (Surgery) in university since 1984, Resident Research Award for best paper in Gastroenterology by American Society of Lasers in Surgery and Medicine at Orlando (USA) in 1992, Young Surgeons award by Japanese Surgical Society at Sendai (Japan) in 1993, WHO fellowship in Cancer at Mayo Clinic, Rochester, Minnesota, USA and WHO fellowship in Cancer at National Institute of Cancer, Milan, Italy in 2000. Commonwealth Clinical Fellow 1991 in Cancer & Laser at University of London at University College Hospital, London; and Middlesex Hospital, & National Medical Laser Center, . UK, Ethicon Visiting Professorship by Association of Surgeons of India in 1997. Presidential Oration of Indian Association of Surgical Oncology 2007, Best paper award at Indian Association of Surgicai Oncology 2001, Travelling Fellowship by UP-ASI, 1981, Rank 1 House Surgeon based on Index of Marks. Fellow of Royal College of Surgeons of Edinburgh, UK, Fellow of Royal College of Surgeons of Glasgow, UK, Fellow of Royal College of Surgeons in Ireland, Dublin, Ireland, Fellow of American College of Surgeons, Fellow of International College of Surgeons (Surgical Oncology),. Examiner Intercollegiate MRCS Examination of Royal College of Surgeons of UK; Examiner, Saudi Commission for Health Specialties- Board for Post Graduate Examination of Surgery (SCHS); University of Dammam and Arabian Gulf University, Bahrain; Examiner of PhD (Surgical Oncology); Examiner ofMCh (Surgical Oncology) at AIIMS New Delhi, TMH Mumbai & BHU. Visiting Surgeon- Mayo Clinic, USA, University of London UK, National Cancer Institute, Tokyo, Japan; National Cancer Institute, Milan, Italy, Northwestern University, Chicago, USA; University of Sydney, Australia. 10. Awarded Padma Shri by Govt. of India in 2016, Dr B C Roy Award 2014 as Eminent Medical Teacher, Awarded Yash Bharti (Highest Civil Award by Govt. of Uttar Pradesh. Ex Vice Chancellor, King George's Medical University, Lucknow. President of Indian Association of Surgical Oncology 2006(Earlier Secretary IASO 2001-2002 & Editorial Secretary 1999-2000.et.al. (Attached 35 Pages CV mentioning Fellow, Membership, Awards, Publications, More than 500 papers presented in InternationallNational/State Conferences with concluding other distinguish activities of National & International Importance).

Proposer : Prof: M. V. Padma Srivastava, Seconder: Dr. Chandrima Shaha


1. Kant Ravi, Masters A, Lees WR, Bown SG, 1992. Interstitial Laser Hyperthermia in Human pancreas tumours : GUT, supplement. Vol. 33 No 1 W69, P S18. (if=17.016, ci=Pilot Study) 2. Amin Z, Donald JJ, Masters A, Kant R, Steger AC, Bown SG, Lees WR, 1993 May. Hepatic metastases: interstitial laser photocoagulation with real-time US monitoring and dynamic CT evaluation of treatment. Radiology. 1993 May; 187(2):339-47. PubMed PMID:8475270. (if=7.469, ci=401) 3. Basu S, Ravi B, Kant R, 1999. Interstitial laser hyperthermia, a new method in the management of fibroadenoma of the breast: A pilot study. Lasers Surg Med. 25 (2):148-52. PubMed PNID:I0455221. (if=2.726, ci= 28) 4. Ravi Kant, 2000 AIDS associated malignancies. Indian Journal of Surgery, Vol. 62, No 5 OctoberNovember, ISSN 0972-2068, page 321-323. (if= 0.509 , ci=37) 5. Hedau S, Jain N, Husain SA, Mandai AK, Ray G, Shahid M, Kant R, Gupta V, Shukla NK, Deo SS, Das BC, 2004 Nov. Novel germline mutations in breast cancer susceptibility genes BRCA1, BRCA2 and p53 gene in breast cancer patients from India. Breast Cancer Res Treat. 2004 Nov; 88(2): 177-86. PubMed PMID: 15564800. (if=3.940, ci=68) 6. Lal P, Singh L, Agarwal PN, Kant R, 2004 Oct-Dec. Open port placement of the first laparoscopic port: a safe technique. JSLS.8(4):364-6. PubMed PMID: 15554282; PubMed Central PMCID: PMC3016831. (if= 0.64, ci=29) 7. Bikhchandani J, Agarwal PN, Kant R, Malik VK, 2005 Jan. Randomized controlled trail to compare the early and mid-term results of stapled versus open hemorrhoidectomy. Am J Surg. 189(1 ):56-60. PubMed PMID: 15701493. (if=2.406, ci=73) 8. Kant R, Neogi S, Ravi Bina & Sahay S, 2006 Book Chapter - Clinical Medicine Update. Hydatid Disease- Current Trends. Ed. AK Agarwal. Jaypee Publications, New Delhi. A Publication of Indian Association of Clinical Medicne. Vol IX. Page 425-433. (if= 5.583, ci=Book Chapter) 9. Techchandani N, Garg PK, Hadke NS, Jain SK, Kant R, MandaI AK, Bhall P, 2010. Predictive factors for successful early laparoscopic cholecystectomy in acute cholecystitis: a prospective study. Int J Surg. 8(8):623-7. Epub 2010 Ju130. PubMed PMID: 20674811. (if= 2.64, ci=28) 10. Bisher HA, Kant R, Aldamati A, Badar AA, 2011 Mar. Plexiform neurofibroma of the submandibular gland in patient with von Recklinghausen's disease. Rate Tumors. 30;3(l)e4. PubMed PMID: 21464877; PubMed Central PMCID: PMC3070454. (if=0.50, ci=2)

349

KAPAETTU, SATYAMOORTHY (b 1960), Professor & Director, School of Life Sciences, Manipal Academy of Higher Education (MAHE), Manipal


Dr. Kapaettu Satyamoorthy qualified with PhD in Biochemistry from Cancer Research Institute, Bombay University, Bombay (1987). During this time, he investigated mechanisms of anticancer drug resistance and was able to devise strategies to increase the therapeutic efficacies (Anticancer Res, 6, 329, 1986; Leukemia Res., 10, 1327, 1986). During his post-doctoral studies (1987-1989) at Kansa’s State University, he demonstrated intrinsic resistance and mechanisms of anthracycline antibiotics (Cancer Res., 49, 5364, 1989). He subsequently joined Wistar Institute Philadelphia, USA, where he worked on the gene regulation and transcription factor discovery (Mol Cell Biol., 13, 6621, 1993; Nucl Acids Res., 25, 3169, 1997) and molecular basis of cancer (Cell Growth Differ., 11, 467, 2000; Oncogene, 20, 4676. 2001; Cancer Res., 61, 7318, 2001; 63, 756, 2003). In 2001, he joined MAHE, Manipal, as Professor and established School of Life Sciences to undertake teaching and research activities in the area of human health. He has continued to work on genetics and epigenetics human diseases and cancer to establish a) epigenetic mechanisms (Mol Carcinog., 57, 370, 2018; 2018; J Transl Med. 13:151, 2015; J. Biol Chem., 289, 10637, 2014; Intl J Radiat Biol., 87, 2011; Mol Oncol., 5, 77, 2011), b) genetics of human diseases and population diversity (Nature Genet.,49, 1403, 2017; Pharnacogenomics, 19, 905, 2018; 15, 349, 2014; Psychiatr Genet., 25, 135, 2015); and cancer genomics (Br J Cancer, 117, 136, 2017; BMC Cancer 16: 271, 2016). He has published over 220 research articles in peer reviewed international journal and has twelve patents.

Proposer: Prof. M.S. Valiathan, Seconder: Prof. K. Dharmalingam


1. Varghese VK, Shukla V, Kabekkodu SP, Pandey D, Satyamoorthy K. 2018. DNA methylation regulated microRNAs in human cervical cancer. Mol Carcinog. 57: 370-382. (if=3.851, ci=7)

2. Nakatsuka N, Moorjani P, Rai N, Sarkar B, Tandon A, Patterson N, Bhavani GS, Girisha KM, Mustak MS, Srinivasan S, Kaushik A, Vahab SA, Jagadeesh SM, Satyamoorthy K, Singh L, Reich D, Thangaraj K. 2017. The promise of discovering population-specific disease-associated genes in South Asia. Nat Genet. 49: 1403-1407. (if=27.125, ci=28)

3. Chakrabarty S, Varghese VK, Sahu P, Jayaram P, Shivakumar BM, Pai CG and Satyamoorthy K. 2017. Targeted sequencing-based analyses of candidate gene variants in ulcerative colitis associated colorectal neoplasia. Br J Cancer 117: 136-143. (if=5.922, ci=2)

4. Joshi MB, Baipadithaya G, Balakrishnan A, Hegde M, Vohra M, Ahamed R, Nagri SK, Ramachandra L, Satyamoorthy K. 2016. Elevated homocysteine levels in type 2 diabetes induce constitutive neutrophil extracellular traps. Scientific Reports. 6: 36362. (if=4.122, ci=11)

5. Rotti H,Mallya S,KabekkoduSP,Chakrabarty S,BhaleS,BharadwajR,Bhat BK,Dedge AP,Dhumal VR,GangadharanGG,Gopinath PM,GovindarajP,Joshi KS,KondaiahP,Nair S,Nair SN,Nayak J,Prasanna BV,Shintre P,Sule M,Thangaraj K,Patwardhan B,Valiathan MV,Satyamoorthy K.2015.DNA methylation analysis of phenotype specific stratified Indian population. J Trans Med 13:151 (if=4.197, ci=20)

6. Kabekkodu SP, Bhat S, Radhakrishnan R, Aithal A, Mascarenhas R, Pandey D, Rai L, Kushtagi P, Mundyat GP and Satyamoorthy K .2014. DNA Promoter Methylation Dependent Transcription of Double C2 Like Domain Beta (DOC2B) Gene Regulates Tumor Growth in Human Cervical Cancer. J Biol Chem. 289: 10637-10649. (if=4.010, ci=19)

7. Rai PS, Pai GC, Alvares JF, Bellampalli R, Gopinath PM and Satyamoorthy K. 2014. Intraindividual somatic variations in MTHFR gene polymorphisms in relation to colon cancer. Pharmacogenomics 15: 349–359. (if=3.812, ci=9)

8. Kumar A, Rai PS, Upadhya R, Vishwanatha, Kabekkodu S, Satish Rao BS, Satyamoorthy K. 2011. γ-Radiation induces cellular sensitivity and aberrant methylation in human tumor cell lines. Int J Radiat Biol. 87: 1086-1096. (if=1.970, ci=24)

9. Satyamoorthy K., Li, G., Garrero, M.R., Bros, M.S., Volpe, P., Weber, B.L., van Belle, P., Elder, D.E., and Herlyn, M. 2003. Constitutive mitogen activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation. Cancer Res. 63: 756-759. (if=9.130, ci=486)

10. Satyamoorthy K., Park, K., Atchison, M., and Howe, C.C. 1993. The intracisternal A particle upstream element interacts with transcription factor YY1 to activate transcription: Pleiotropic effects of YY1 on distinct DNA promoter elements. Mol. Cell Biol. 13: 6621-6628. (if=3.813, ci=65)

350

NANDINENI, MADHUSUDAN REDDY (b 1973), Staff Scientist and Group Leader, Centre for DNA Fingerprinting and Diagnostics (CDFD), Uppal, Hyderabad


The nominee had an excellent educational background and won several awards during his studies as is evident from his curriculum vitae. His Ph.D. research work at CCMB, Hyderabad had identified five hitherto unknown novel genes that are involved in osmoregulation in Escherichia coli and a part of which was granted international patents. After his post-doctoral research work at the Yale University School of Medicine, the nominee in August 2005 joined CDFD, Hyderabad, which is a referral centre for forensic DNA profiling work in India. Under his supervision, the group has handled >2600 forensic DNA profiling cases in the last 13 years from the various law enforcement agencies and Courts of law across the country, including some of the challenging mass disaster cases from different regions in India like Nithari killings cases from NOIDA in Uttar Pradesh, Air India Express air crash at Mangalore, Samjoutha Express Train bomb blast case, Uttarakhand flood victims, etc. and several cases involving national security and public safety (terror-related cases). The nominee, as Govt. of India Expert Member, was associated with drafting of DNA legislation (Human DNA Profiling Bill) for the country. He has made great efforts at popularizing the use of DNA profiling technology in civil and criminal proceedings in the justice delivery system in the country. His research group is involved in studies on human population genetics, forensic DNA phenotyping and to develop new methodologies for increasing the success rate of DNA profiling of recalcitrant and challenging forensic exhibits.

Proposer: Dr. J. Gowrishankar, Seconder: Dr. Sangita Mukhopadhyay


1. Singh M, Sarkar A, Nandineni MR. (2018). A comprehensive portrait of Y-STR diversity of Indian populations and comparison with 129 worldwide populations. Scientific Reports. 8(1):15421. doi: 10.1038/s41598-018-33714-2). (Impact factor:4.12; Citations: Nil) (if=4.12)

2. Rao S, Sharda S, Oddi V and Nandineni MR. (2018). The Landscape of Repetitive Elements in the Refined Genome of Chilli Anthracnose Fungus Colletotrichum truncatum. Frontiers in Microbiology. 9:2367. doi: 10.3389/fmicb.2018.02367. eCollection 2018.(if=4.07)

3. Sarkar A and Nandineni MR. (2017). Association of common genetic variants with human skin colour variation in Indian populations. American Journal of Human Biology. doi: 10.1002/ajhb.23068 (if=1.92, ci=1)

4. Sarkar A, Stoneking M and Nandineni MR. (2017). Unraveling the human salivary microbiome diversity in Indian populations. PLoS ONE 12(9):e0184515. https://doi.org/10.1371/journal.pone.0184515. (if=2.76, ci=3)

5. Sarkar A and Nandineni MR. (2017). Development of a SNP-based panel for human identification for Indian populations. Forensic Science International- Genetics; 27:58-66. doi:10.1016/j. fsigen.2016.12.002 (if=5.63, ci=4)

6. Singh M and Nandineni MR. (2017). Population genetic analyses and evaluation of 22 autosomal STRs in Indian populations. International Journal of Legal Medicine. doi: 10.1007/s00414-016-1525-y. (if=2.31, ci=3)

7. Gadipally SR, Sarkar A and Nandineni MR. (2015). Selective enrichment of STRs for applications in forensic human identification. Electrophoresis, 36(15):1768-74. doi: 10.1002/elps.201400490. Epub 2015 Jun 23. (if=3.02, ci=2)

8. Reich D, Patterson N, Kircher M, Delfin F, Nandineni MR, et al. (2011). Denisova Admixture and the First Modern Human Dispersals into Southeast Asia and Oceania. American Journal of Human Genetics, 89(4): 516-528. (if=9.02, ci=438)

9. Gunnarsdóttir ED, Nandineni MR, et al. (2011). Larger mtDNA than Y-chromosome differences between matrilocal and patrilocal groups from Sumatra. Nature Communications, 2:228. (if=12.35, ci=38)

10. Nandineni MR and Gowrishankar, J. (2004). Evidence for an arginine exporter encoded by yggA (argO) that is regulated by the LysR-type transcriptional regulator ArgP in Escherichia coli. Journal of Bacteriology, 186:3539-3546. (if=3.21, ci=72)

https://doi.org/10.1371/journal.pone.0184515

351

PANDIT, LEKHA (b 1959), KS Hegde Medical Academy,Nitte (deemed to be university), Mangalore


Dr Lekha Pandit trained as a clinical neurologist and later learnt molecular genetics,cementing her skills by completing a PhD in Biosciences and a research scholarship at University of Cambridge,UK. She set up a committed research laboratory at her university, and started the Mangalore Demyelinating disease registry in 2007 which has over 1250 patients who are actively followed longitudinally. What sets her apart is that in the ensuing years, she combined her clinical and research skills and generated new and India specific data which has improved the understanding of multiple sclerosis (MS) and Neuromyelitis Optica Spectrum Disorders (NMOSD). Three years before the diagnostic criteria for NMOSD were published, she vividly described these conditions as being distinctly different from multiple sclerosis (#10) and cemented her pioneering role in the field of CNS autoimmune disorder research. Her epidemiological study in southern India showed that MS was nearly 10 times more than previously known and she provided the first epidemiological data for NMOSD in India (#6). She published robust studies on the genetics of MS among Indians that conclusively showed strong similarity between white Europeans and Indians( #1,2,9) and also for NMOSD (#3). Her work on environmental factors associated with MS among Indians showed striking differences from European populations (4,7,8). Internationally recognized in the field, she was the lead author in an international collaboration which described the clinical and demographic features of NMOSD ( #5).

Proposer: Dr. Vijayalakshmi Ravindranath, Seconder: Dr. M.S. Valiathan


1. Pandit L, Maria B, Beecham AH et al. European multiple sclerosis risk variants in the south Asian population. Mult Scler 2016; 22: 1536-1540. (if=5.28, ci=3.01)

2. Pandit L, Malli C, Singhal B et al. HLA association in South Asian Multiple Sclerosis. Mult Scler 2016;22:19-24 (if=5.28, ci=3.01)

3. Pandit L, Malli C, D’Cunha A et al. HLA association in Neuromyelitis Optica in Indian population . Mult Scler 2015; 21:1217-8. (if=5.28, ci=3.01)

4. Malli C, Pandit L, D’Cunha A et al. Environmental factors related to Multiple sclerosis in Indian population. 2015 PLoS ONE 10(4): e0124064 (if=2.76)

5. Pandit L, Asgari N, Apiwattanakul M et al. Demographic and Clinical features of Neuromyelitis optica- A review. Mult scler 2015; 21(7):845-53. (if=5.28, ci=3.01)

6. Pandit L, Kundapur R. Prevalence and patterns of demyelinating central nervous system disorders in urban Mangalore, South India in India. Mult Scler 2014; 20:1651-3. (if=5.28, ci=3.01)

7. Pandit L, Ramagopalan SV, Malli C, D’Cunha A, Kunder R, Shetty R, Association of vitamin D and multiple sclerosis in India. Mult Scler 2013; 19:1592- 1596. (if=5.28, ci=3.01)

8. Pandit L, Malli C, D’Cunha A et al. Association of Epstein–Barr virus infection with multiple sclerosis in India. J Neurol Sci 2013;325: 86-89. (if=2.536, ci=2.03)

9. Pandit L, Ban M, Sawcer N et al. Evaluation of the established non-MHC Multiple Sclerosis loci in an Indian Population. Mult Scler 2011; 17:139-143 (if=5.28, ci=3.01)

10. Pandit L, Rao S N. Recurrent Myelitis. Journal of Neurology Neurosurgery and Psychiatry 1996; 60: 336-338. (if=7.14)

352

PATI, SANGHAMITRA (b 1969), Scientist-G & Director, ICMR-Regional Medical Research Centre, Bhubaneswar


Dr. Sanghamitra Pati, a physician turned health research scientist, is working as the Director of ICMR-RMRC Bhubaneswar. For the past two decades, her work has been focused on prevention and management of chronic, endemic in primary care practice, tobacco control, nutrition, water & sanitation, diseases prevention & health promotion in both community and primary care settings, which is evident by scientific publications in various journal of repute like The Lancet, The Lancet Oncology, Lancet Diabetes, BMC Medicine, PLOS One etc. She is recipient of various international and national awards from Well come Trust, Harvard school of Public Health, ABC foundation, Merieux fellowship, Bursary award, International Society of Behavioural Medicine, USA, ISID fellowship, American association of University Women (AAUW), WONCA Europe etc. She had developed a smoking cessation skill building program for medical students which won her APACT Young Investigator Award and early career award from International Society of Behavioural Medicine (2010, 2012) for integrating behavioural health interventions into health professional education. Since her joining as director, ICMR-Regional Medical Research Centre, Bhubaneswar has expanded its horizon to various field like Public Health, Health System Research, Health Technology Assessment, zoonotic diseases. She has mentored interns of ICMR-IIT-IIM funded Medtech Internship Programme. She is also advisor & coordinator of various projects related to medical technology/innovation like MAMA (Mobile Application for Mother Assistance), CHER (Continuous Heart Rate, ECG & Respiratory rate monitoring system), SMILE (Screening expecting mothers by indigenous low cost and effective devices), IPMD (Intrapartum monitoring devices).

Proposer: Dr. Bhabani Sankar Das, Seconder: Dr. Gagan Bihari Nityananda Chainy


1. Pati S, Sinha R, Panda M, Pati S, Sharma A, Zodpey S. 2017. Global Health Teaching in India: A Curricular Landscape. Front Public Health. 5:259. doi: 10.3389/fpubh.2017.00259 (ci=2)

2. Pati S, Swain S, Metsemakers J, Knottnerus JA, van den Akker M.2017. Pattern and severity of multimorbidity among patients attending primary care settings in Odisha, India. PLoS One. 12(9):e0183966. doi: 10.1371/journal.pone.0183966. (if=2.913, ci=2)

3. Pati S, Hussain MA, Swain S,et al. 2016. Development and Validation of a Questionnaire to Assess Multimorbidity in Primary Care: An Indian Experience, BioMed Res Int., doi:10.1155/2016/6582487. (if=2.476, ci=3)

4. Pati S, Swain S, Hussain MA, van den Akker M, Metsemakers J, Knottnerus JA, Salisbury C. 2015. Prevalence and outcome of multi morbidity in South Asia: a systematic review. BMJ Open. 5(10):e007235. (if=2.369, ci=4)

5. Kowal P, ArokiasamyP, Afshar S, Pati S, Snodgrass J. 2015Multimorbidity: health care that counts “past one” for 1.2 billion older adults. The Lancet, 385(9984) 2252-2253 (if=47.831, ci=4)

6. Pati S, Agrawal S, Swain S, Lee JT, Vellakkal S, Hussain MA, Millett C. 2014. Non communicable disease multi-morbidity and associated health care utilization and expenditures in India: cross-sectional study. BMC Health Serv Res. 14(1):451. (if=1.827, ci=5)

7. Pati S, Sharma A, Zodpey S. 2014. Teaching of public health ethics in India: a mapping exercise. Indian Journal of Medical Ethics, 2014; 11 (3): 185-90. (ci=2)

8. Pati S, Chauhan AS, Swain S, Panda M, Hussain MA. 2014. Neonatal care practices in a tribal community of Odisha, India: A cultural perspective. Journal of Tropical Pediatrics doi: 10.1093/tropej/fmu005 (if=1.093, ci=3)

9. Pati S, Hussain MA, Chauhan AS, Mallick D, Nayak S.2013. Patient Navigation pathway and barriers to care seeking in cancer in India: A Qualitative Inquiry.Cancer Epidemiol. 37(6):973-8. (if=2.343, ci=4)

10. Lawson C, Pati S, Green J, Messina G, Strömberg A, Nante N, Golinelli D, Verzuri A, White S, Jaarsma T, Walsh P, Lonsdale P, Kadam UT. 2017. Development of an international comorbidity education framework.Nurse Educ Today. 55:82-89. doi: 10.1016/j.nedt.2017.05.011. (if=2.533, ci=1)

353

RISHI, PRAVEEN (b 1958), Professor and Ex-Dean, Faculty of Science, Panjab University, Chandigarh


Recent research work of Prof. (Mrs.) Praveen Rishi has revealed for the first time that i) Cadmium acquired by Salmonella from the environment, is one of the factors for the enhanced antibiotic resistance of the pathogen. ii) She has also reported that in the presence of antimicrobial peptides, Salmonella is rendered sensitive to the antibiotics to which it is otherwise resistant. iii) In the field of diagnostic microbiology, she has developed antibody/ aptamer prototypes for detection of Salmonella in collaboration with Institute of Microbial Technology (IMTECH), Chandigarh. In this context, technology has already transferred to the industry to develop the diagnostic kit. She has been the recipient of Dr. Y.S. Narayana Rao Oration Award (ICMR) and has recently been conferred with Prof. S.R. Vyas Memorial Award (AMI-2018). Dr. Rishi has 131 research publications to her credit and has also filed two patents. In view of her consistent outstanding work in the field of Microbiology, she was elected Fellow, Academy of Microbiological Sciences, India (FAMSc, 2009) and Fellow, Indian Association of Biomedical Scientists (FABMS-2011).

Proposer: Dr. Javed N. Agrewala, Seconder: Prof. K.K. Bhasin


1. Pathania, P.K., Saini, J.K., Vij, S., Tewari, R., Sabherwal, P., Rishi, P. and Suri, C.R., 2018. Aptamer functionalized MoS2-rGO nanocomposite based biosensor for the detection of Vi antigen. Biosensors and Bioelectronics, 122: 121-126. (if= 8.17, ci=-)

2. Pathania P, Sharma A, Kumar B, Rishi P, Suri CR. Selective identification of specific aptamers for the detection of non-typhoidal salmonellosis in an apta-impedimetric sensing format. Microchimica Acta. 2017 May 1;184(5):1499-508. (if= 5.7, ci= 3 )

3. Kaur, U.J., Preet, S. and Rishi, P., 2018. Augmented antibiotic resistance associated with cadmium induced alterations in Salmonella enterica serovar Typhi. Scientific Reports, 8(1),p.12818. (if= 4.12, ci= 1)

4. Singh, AP., Preet S., Rishi, P. 2014. Nisin/β-lactam adjunct therapy against Salmonella enterica serovar Typhimurium: a mechanistic approach. Journal of Antimicrobial Chemotherapy (2014) 69 (7): 1877-1887. (IF-5.213, CI-16) (if= 5.21, ci= 16)

5. Bharrhan, S., Koul, A., Chopra, K. and Rishi, P., 2011. Catechin suppresses an array of signalling molecules and modulates alcohol-induced endotoxin mediated liver injury in a rat model. PLoS One, 6(6), p.e20635. (IF - 4.092, CI - 56) (if= 4.09, ci= 56)

6. Preet S., Verma, I. & Rishi, P. Cryptdin-2: a novel therapeutic agent for experimental Salmonella infection. Journal of Antimicrobial Chemotherapy 65 (5): 991-994, 2010 (IF - 4.65, CI - 24) (if= 4.65, ci= 24)

7. Rishi, P., Preet, S., Bharrhan, S. and Verma, I., 2011. In vitro and in vivo synergistic effects of cryptdin 2 and ampicillin against Salmonella. Antimicrobial Agents and Chemotherapy, 55(9), pp.4176-4182. (IF - 4.47, CI - 28) (if= 4.47, ci= 28)

8. Kaur, G., Tirkey, N., Bharrhan, S., Chanana, V., Rishi, P. and Chopra, K. Inhibition of oxidative stress and cytokine activity by Curcumin in amelioration of Endotoxin-induced experimental hepatotoxicity in rodents. Clinical and Experimental Immunology. 145(2): 313-321, 2006 (if= 3.13, ci= 140)

9. Rishi P, Singh A, Arora S, Garg N, Kaur IP. (2013).Revisting anti-infective eukaryotic biotherapeutics. Critical Reviews in Microbiology DOI : 10.3109/1040841X.2012.749210. (if= 6.27, ci= 7)

10. Rishi, P., Mavi, S.K., Bharrhan S, Shukla, G., Tewari, R. Protective efficacy of probiotic alone or in conjunction with prebiotic in Salmonella-induced liver damage. FEMS Microbioogy Ecology 69(2): 222-230, 2009. (if= 3.59, ci= 74)

354

ROY, TARA SANKAR (b 1955), Professor and Head, Department of Anatomy, All India Institute of Medical Sciences, New Delhi


Prof Roy has made significant contributions towards the understanding of development and aging of the human auditory system. He, for first time reported that human fetal auditory system is mature during 20th week of gestation, signifying onset of hearing. He also demonstrated that onset of aging process in the auditory system in Indians start very early, at 4th decade of life. He has established neurotoxicology and pancreatology laboratory in AIIMS. His current research focus on animal model of acute pancreatitis. He has guided 10 PhD, 12 MD, 6 MSc and innumerable undergraduate students. He is a devoted teacher and popular among students for his unique teaching methodology. He developed soft embalming process for cadavers to be used for various surgical maneuvers. Over the years due to his continuous efforts, methods of teaching, evaluation and research methodology he became popular in the country. Thus, Prof Roy’s professional and scientific achievements qualify him for the fellowship of the Academy.

Proposer: Dr. Ravinder Goswami, Seconder: Dr. N.R. Jagannathan


1. TS Roy, FJ Seidler, TA Slotkin. 2002. Prenatal nicotine exposure evokes alterations of cell structure in hippocampus and somatosensory cortex Journal of Pharmacology and Experimental Therapeutics 300 (1), 124-133. (if=3.867, ci=171)

2. TS Roy, JE Andrews, FJ Seidler, TA Slotkin. 1998. Nicotine evokes cell death in embryonic rat brain during neurulation, Journal of Pharmacology and Experimental Therapeutics 287 (3), 1136-1144. (if=3.867, ci=153)

3. B Ray, TS Roy, S Wadhwa, KK Roy.2005. Development of the human fetal cochlear nerve: a morphometric study. Hearing research 202 (1-2), 74-86. Article has been cited in 40th and 41st edition of Gray's Anatomy,Sec 4, Page 642. (if=2.824, ci=30)

4. R Chauhan, TS Roy. 2002. Communication between the median and musculocutaneous nerve–a case report. J Anat Soc India 51 (1), 72-75. (if=0.21, ci=93)

5. TS Roy, U Sabherwal. 1998. Effects of gestational nicotine exposure on hippocampal morphology. Neurotoxicology and teratology 20 (4), 465-473. (if=2.762, ci=93)

6. TS Roy, U Sabherwal. 1994. Effects of prenatal nicotine exposure on the morphogenesis of somatosensory cortex. Neurotoxicology and teratology 16 (4), 411-421. (if=2.762, ci=89)

7. TS Roy, V Sharma, FJ Seidler, TA Slotkin.2005. Quantitative morphological assessment reveals neuronal and glial deficits in hippocampus after a brief subtoxic exposure to chlorpyrifos in neonatal rats. Developmental brain research 155 (1), 71-80. (if=3.27, ci=80)

8. TS Roy, FJ Seidler, TA Slotkin.2004. Morphologic effects of subtoxic neonatal chlorpyrifos exposure in developing rat brain: regionally selective alterations in neurons and glia. Developmental brain research 148 (2), 197-206. (if=3.27, ci=71)

9. M Kumar, T Agarwal, S Khokhar, M Kumar, P Kaur, TS Roy, R Dada.2011. Mutation screening and genotype phenotype correlation of α-crystallin, γ-crystallin and GJA8 gene in congenital cataract. Molecular vision 17, 693. (if=2.245, ci=41)

10. AK Sarkar, TS Roy. 2000.Anatomy of the cystic artery arising from the gastroduodenal artery and its choledochal branch—a case report. Journal of anatomy 197 (3), 503-506. (if=2.097, ci=39)

355

SENGUPTA, AMITAVA (b 1978), Senior Scientist, CSIR-Indian Institute of Chemical Biology (CSIR-IICB), Kolkata


Dr Amitava Sengupta has made significant contribution towards understanding of hematopoiesis, molecular pathology of myeloid leukemia and cancer epigenetics. He and his group identified genetic determinants of mammalian hematopoietic-stem-cell (HSC) physiology, bone-marrow microenvironment, and leukemia genetics. He unraveled role of RacGTPases in leukemia-stem cell activity (Blood 2010), and epigenetic regulators in tumor cell de-differentiation, reprogramming (Blood 2012). He designed gene-therapy vectors against BCR-ABL+-leukemia (Leukemia 2007, J Gene Medicine 2006). He identified functional immunological (Macrophage-Osteoblast) niche required for HSC bone-marrow retention (Cell Reports 2014). His findings based on mice genetics, repudiated dogma of cell polarity in hematopoiesis (PNAS 2011, Nature Medicine 2010). His seminal contribution in identification of molecular determinants of hematopoiesis has tremendous implications in HSC-transplantation and transfusion medicine. His present group has discovered novel epigenetic fingerprints in human myelodysplasia, acute-myeloid-leukemia (MDS/AML) pathobiology. His lab highlighted that chromatin remodeler plasticity in AML bestows oncogenic properties (Mol Cancer Research, 2017). His research underscored synthetic lethality in AML precision medicine (FASEB J 2019); AML cohort with specific gene expression, are sensitive to molecular-targeted therapy. His team proposed chromatin-modifying enzymes as therapeutic targets in AML (Exp Hematology, 2017; ACS-Chemical Biology). They identified unique expression signature in human bone-marrow failure (Exp Hematology, 2018). His ongoing research on systems hematology is harnessing epigenetics towards cancer immunotherapy. His lab is spearheading CRISPR/Cas-gene editing of sickle-HSCs. Overall, within hardly 15years, Dr Sengupta already contributed immensely to understanding of molecular mechanisms of hematopoiesis and cancer. He continues to lead research with great potential for applications in clinical medicine.

Proposer: Dr. Vishwa Mohan Katoch, Seconder: Prof. Samit Chattopadhyay


1. Biswas M, Chatterjee SS, Boila LD, Chakraborty S, Banerjee D, Sengupta A*. 2019 MBD3/NuRD loss participates with KDM6A program to promote DOCK5/8 expression and Rac GTPase activation in human acute myeloid leukemia. FASEB J doi:10.1096/fj.201801035R (if=5.6, ci=na, downloaded 40 times as of 17 Feb 2019 )

2. Chatterjee SS, Biswas M, Boila LD, Banerjee D, Sengupta A*. 2018 SMARCB1 deficiency integrates epigenetic signals to oncogenic gene expression program maintenance in human acute myeloid leukemia. Mol Cancer Research (an official journal of AACR) 16, (if=5.0, ci=2+)

3. Sinha S, Chatterjee SS, Biswas M, Nag A, Banerjee D, De R, Sengupta A*. 2018 SWI/SNF subunit expression heterogeneity in human aplastic anemia stem/progenitors. Exp Hematology (the official journal of ISEH) 62, 39-44. Cover Page Article (if=3.0, ci=2+)

4. Boila LD, Chatterjee SS, Banerjee D, Sengupta A*. 2018 KDM6 and KDM4 demethylases emerge as molecular therapeutic targets in human acute myeloid leukemia. Exp Hematology 58, 44-51. (if=3.0, ci=6+)

5. Chang KH1, Sengupta A1, Nayak R, Duran A, Lee SJ, Pratt R, Wellendorf AM, Hill SE, Watkins M, Gonzalez-Nieto D, Aronow BJ, Starczynowski DT, Civitelli R, Diaz-Meco MT, Moscat J, Cancelas JA. 2014 p62 is required for stem cell/progenitor retention thr (if=8.0, ci=30+)

6. Sengupta A, Ficker A, Dunn S, Madhu M, Cancelas JA. 2012 Bmi1 reprograms chronic myelogenous leukemia B-lymphoid progenitors to become B-ALL-initiating cells. Blood 119, 494-502. (if=15, ci=26+)

7. Sengupta A, Duran A, Ishikawa E, Florian M, Dunn S, Ficker A, Leitges M, Geiger H, Diaz-Meco MT, Moscat J, Cancelas JA. 2011 aPKCζ and aPKCλ are dispensable in hematopoietic stem cell activity and blood formation. Proc Natl Acad Sci USA 108, 9957-996 (if=10, ci=44+)

8. Sengupta A, Arnett JA, Dunn S, Williams DA, Cancelas JA. 2010 Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo. Blood 116, 81-84. (if=15, ci=47+)

9. Sengupta A, Banerjee D, Chandra S, Banerji SK, Ghosh R, Roy R, Banerjee S. 2007 Deregulation and cross talk among Sonic hedgehog, Wnt, Hox and Notch signaling in chronic myeloid leukemia progression. Leukemia 21, 949-955. (if=12, ci=165+)

10. Sengupta A, Banerjee D, Chandra S, Banerjee S. 2006 Gene therapy for BCR-ABL+ human CML with dual phosphorylation resistant p27Kip1 and stable RNA interference using an EBV vector. J Gene Med 8, 1251-1261. (if=3.0, ci=23+)

356

SINGH, SARMAN (b 1956), Director, All India Institute of Medical Sciences (AIIMS), Bhopal


Prof. Singh is focusing on point-of-care (POC) test device development. He has 8 patents, three of these are ground-breaking technological discoveries. The indigenous rapid diagnostic test (RDT) kits developed for kala-azar at a very affordable price are having 100% specificity and 98% sensitivity. This technology has been taken-up by the Government of India in its kala-azar elimination programme, thus he has attained a distinction of being the first medical scientist whose technology has served the national disease control programme. He has been awarded by British Medical Journal, Indian Medical Association, Delhi Medical Association, Medical Council of India, Government of Uttar Pradesh, the Department of Biotechnology among others. For the diagnosis of tuberculosis his team has identified 5 novel antigens that are over-expressed only during the in-vivo drug resistance development. These antigens have shown very high sensitivity (98.2% -100%) and specificity (89.1 - 98.2%). He is Fellow of 6 national and international Academies and Member of more than 20 scientific bodies. He has written 6 books, 46 book chapters and more than 321 research papers in various indexed journals, with a total citation of 8900, i10 index of 173 and h-index of 43. Prof. Sarman Singh did his MBBS from KGMC, Lucknow, and MD from PGIMER Chandigarh. He has made several landmark discoveries and has developed point-of-care rapid test devices for kala-azar and Tuberculosis. The kala-azar Rapid Diagnostic Test kit is being used in the national kala-azar elimination programme of the Government of India.

Proposer: Prof. Subrata Sinha, Seconder: Prof. Sanjay K. Agarwal


1. Singh S*, Veena Kumari, Singh N. (2002) Predicting Kala-Azar Disease Manifestations in Asymptomatic Patients with Latent Leishmania donovani Infection by Detection of Antibody against Recombinant K39 Antigen. Clin Diagn Lab Immunol; 9: 568-72. .(if=2.09, ci=115)

2. Singh S*, Mohanty A, Joshi YK, Deka D, Mohanty S, Panda SK. (2003) Mother-to-child transmission of hepatitis E virus infection. Indian J Paed, 70: 37-39. (if=0.9, ci=121)

3. Singh S, Sivakumar R. (2004) Challenges and new discoveries in the Treatment of Leishmaniasis. Review. J Infect Chemother 10 (6): 307-315 (if=1.52, ci=291)

4. Sivakumar, R., Sharma, P., Chang, K.-P., and Singh S.* (2006). Cloning, expression, and purification of a novel recombinant antigen from Leishmania donovani. Protein Expr. Purif. 46, 156–165. (if=1.695, ci=57)

5. Gopinath, K., and Singh S.* (2009). Multiplex PCR assay for simultaneous detection and differentiation of Mycobacterium tuberculosis, Mycobacterium avium complexes and other Mycobacterial species directly from clinical specimens. J. Appl. Microbiol. 107, 425–435. Citation-83 (IF-2.60). (if=2.60, ci=83)

6. Kumar, D., Nath, L., Kamal, M.A., Varshney, A., Jain, A., Singh S, and Rao, K.V.S. (2010). Genome-wide Analysis of the Host Intracellular Network that Regulates Survival of Mycobacterium tuberculosis. Cell 140, 731–743. (if=31.398, ci=284)

7. Rufai SB, Kumar P, Singh A, Prajapati S, Balooni V, Singh S*. (2014) Comparison of Xpert MTB/RIF with Line Probe Assay for Detection of Rifampin-Monoresistant Mycobacterium tuberculosis. J Clin Microbiol. Jun;52(6):1846-52. doi: 10.1128/JCM.03005-13.(if=4.232, ci=77)

8. Singh, J., Sankar, M.M., Kumar, P., Couvin, D., Rastogi, N., Singh S*, and Indian TB Diagnostics Network (2015). Genetic diversity and drug susceptibility profile of Mycobacterium tuberculosis isolated from different regions of India. J. Infect. 71, 207–219. (if=4.603, ci=25)

9. Srivastava S, Mishra J, Gupta AK, Singh A, Mishra PS, Singh S*. (2017) Laboratory Confirmed Miltefosine Resistant Cases of Visceral Leishmaniasis from India. Parasites & Vectors 10:49 DOI 10.1186/s13071-017-1969-z, Citation-36, IF-3.603,(IF: 3.41). (if=3.603, ci=36)

10. Singh A, Gupta A, Gopinath K, Sharma P, Singh S*. (2017) Evaluation of 5 Novel protein biomarkers for the rapid diagnosis of pulmonary and extra-pulmonary tuberculosis: preliminary results. Nature Sc Rep, 2017; 7:44121 (1-10). DOI: 10.1038/srep44121 Citation-8 (IF-4.303). (if=4.303, ci=8)

357

SRINIVAS, PRIYA (b 1972), Scientist F, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapurman


Dr. Priya Srinivas has made seminal contributions in analysing the genetic cause of hereditary breast ovarian cancers, unleashing the possibilities to attenuate the tumor development and unravelling the implications of BRCA defects, for which she has won several National and International accolades, including the prestigious ICMR Prem Nath Wahi Award (2013), and the American Association of Cancer Research-National Cancer Institute (NCI) International Investigator Opportunity Grants, USA (2008). Dr. Srinivas has more than 1300 citations and has an H-index of 15 for her research publications which amounts to about 40 international peer reviewed publications, in high impact factor journals. She has presented her work in more than 70 conferences and has mentored 7 PhD students for their doctoral thesis. She has successfully completed 10 research projects which were funded by various government funding agencies. Dr. Srinivas has proved for the first time, the targeted anti-cancer activity a plant derived naphthoquinone, Plumbagin in BRCA1 defective cancers. She has also been granted an Indian Patent in 2017, for the mechanism by metal chelated copper carbohydrazome complex and its combination with plumbagin in breast cancer cells. For the first time, she has confirmed that CAFs are transformed to Metastasis Associated Fibroblasts (MAF), when co-cultured with BRCA1 deficient but not with BRCA1 wild type breast cancer cells. Also, Dr. Srinivas’s demonstrated that the pregnancy hormone, β-hCG, increases tumorigenesis in BRCA1 mutated, but not BRCA1 wild type women. Undoubtedly, Dr. Priya Srinivas possesses a unique scientific accomplishment profile as a Cancer Research Scientist.

Proposer: Prof. Chandrima Shaha, Seconder: Prof. M. Radhakrishna Pillai


1. Priya Srinivas, Gokul Gopinath, Asoke Banerji, Abhilash Dinakar, Gopal Srinivas. 2004. Plumbagin induces reactive oxygen species mediated apoptosis in human cervical cancer cells. Mol. Carcinogenesis, 39(1): 15-25 (if=3.265, ci=189)

2. Gopal Srinivas, Lois A Annab, Gokul Gopinath, Asoke Banerji, Priya Srinivas. 2004. Antisense blocking of BRCA1 enhances the sensitivity to plumbagin but not tamoxifen in BG-1 ovarian cancer cells. Mol Carcinogenesis, 40; 201-211 (if=3.265, ci=58)

3. Thasni KA, Rakesh S, Rojini G, Ratheeshkumar T, Srinivas G, Priya Srinivas. 2008. Estrogen-dependent cell signaling and apoptosis in BRCA1-blocked BG1 ovarian cancer cells in response to plumbagin and other chemotherapeutic agents. Ann Oncol 19: 4; 696-705(if=5.17 , ci=68)

4. K A Thasni, G Rojini, S. Nair Rakesh, Thankappan Ratheeshkumar, Mani Shankar Babu, Gopala Srinivas, Asoke Banerji, Priya Srinivas. 2008, Genistein induces apoptosis in ovarian cancer cells via different molecular pathways depending on Breast Cancer Susceptibility gene-gene-1 (BRCA1) status. European Journal of Pharmacology, Vol 588, 2-3, p 158- (if=2.482, ci=38)

5. Priya Srinivas, Chitta Ranjan Patra, Santanu Bhattacharya and Debabrata Mukhopadhyay. 2011, Cytotoxicity and ROS generating capacity of naphthaquinones is quenched when conjugated with gold nanoparticles. International J of Nanomedicine: 6 2113–2122.(if=4.97, ci=20)

6. Thasni KA, Ratheeshkumar T, Rojini G, Sivakumar KC, Rakesh Sathish Nair, Srinivas G, Asoke Banerji, Veena Somasundaram, Priya Srinivas. 2013, Structure activity relationship of Plumbagin in BRCA1 related Cancer Cells. Mol Carcinog. 52, 392-403. (if=4.269, ci=18)

7. Sinha, S., Pal, K., Elkhanany, A., Dutta, S., Cao, Y., Mondal, G., Iyer, S., Somasundaram, V., Couch, F. J., Shridhar, V., Bhattacharya, R., Mukhopadhyay, D. and Srinivas, Priya. 2013, Plumbagin inhibits tumorigenesis and angiogenesis of ovarian cancer cells in vivo. Int. J. Cancer: 132, 1201-1212. (if=6.198, ci=68)

8. Rakesh S Nair; Mini Kuriakose; Veena Somasundaram; Vinesh Shenoi; M.R. Prathapachandra Kurup; Priya Srinivas, 2014. The Molecular Response of a Novel Vanadium Complex of Nicotinoyl Hydrazone in Cervical Cancers - A Possible Interference with HPV Oncogenic Markers. Life Sciences 116, 90–97. IF. 2.538. (if= 2.538, ci=23)

9. Reshma RS, Sreelatha KH, Veena Somasundaram, Satheesh Kumar S, Revathy, Rakesh Sathish Nair, Priya Srinivas. 2016, Plumbagin, a naphthaquinone derivative induces apoptosis and in BRCA 1/2 defective castrate resistant prostate cancer cells as well as prostate cancer stem-like cells. Pharmacological Research Volume 105, Pages 134–145. (if=4.408, ci=12)

10. Satheesh K S, Revathy N, Rakesh S N, Sreelatha K H, Veena S, Reshma R S, Arathi R, Neetha R L, Geetu R V, Ratheeshkumar T, Jerald M Kumar, Arkadiusz Chil, Thapasimuthu V Anilkumar, Priya Srinivas. 2018, BRCA1 regulation on β-hCG: A mechanism for tumorigenicity in BRCA1 defective breast cancer. Oncogenesis, 6(9):e376. (if=4.722., ci=7)

358

SRINIVASAN, NARAYANAN (b 1968), Professor, University of Allahabad, Prayagraj


The most innovative contribution by Prof. Srinivasan to the discipline is elucidating the nature of scope of attention and full range of effects of scope of attention on other mental processes. The findings on scope of attention range from the nature of computations performed with broad scope of attention and showing using event-related potentials as a tool that broad scope of attention is involved in computing statistical summaries in vision. Using dwell time paradigm, Prof. Srinivasan has shown the nature of shifting attention from one spatial scope to another. Designing novel experimental paradigms, Prof. Srinivasan has shown reciprocal interactions between scope of attention and emotion perception; broad scope of attention is linked to happy emotions and narrow scope of attention is linked to sad emotions. By making people engage in a task that manipulates scope of attention, he has shown that broad scope of attention is linked to better memory and preference. More importantly, he has shown that changes in scope of attention lead to changes in visual awareness. Scope of attention is also linked to different types of meditation and he has shown that focused attention meditation leads to better pre-attentive processing and changes in visual awareness.

Proposer: Prof. Mewa Singh, Seconder: Prof. U.C. Srivastava


1. Ge, D., Srinivasan, N. and Krishnan, S.M. (2002). Cardiac arrhythmia classification using autoregressive modeling. Biomedical Engineering Online, 1, 5. (if=1.676, ci=279)

2. Srinivasan, N., & Baijal, S. (2007). Concentrative meditation enhances pre-attentive processing: A MMN study. Neuroreport, 18, 1709-1712. (if=1.343, ci=98)

3. Baijal, S., & Srinivasan, N. (2010). Theta activity and meditative states: Spectral changes during Sahaj Samadhi meditation. Cognitive Processing, 11, 31-38. (if=1.15, ci=127)

4. Srivastava, P., & Srinivasan, N. (2010). Time course of visual attention with emotional faces. Attention, Perception, & Psychophysics, 72, 369-377. (if=1.678, ci=55)

5. Srinivasan, N., & Hanif, A. (2010). Global-happy and local-sad: Perceptual processing affects emotion identification. Cognition & Emotion, 24, 1062-1069. (if=2.563, ci=80)

6. Baijal, S., Jha, A., Kiyonaga, A., Singh, R., & Srinivasan, N. (2011). The influence of concentrative meditation training on the development of attention networks in early adolescence. Frontiers in Psychology, 2:153. (if=2.059, ci=57)

7. Tewari, S., Khan, S.S., Hopkins, N., Srinivasan, N., & Reicher, S. (2012). Participation in mass gatherings can benefit well-being: Longitudinal and control data from a North Indian Hindu pilgrimage event. PLOS ONE, 7(10), e47291. (if=2.766, ci=83)

8. Srinivasan, N., Hopkins, N., Reicher, S., Khan, S.S., Singh, T., & Levine, M. (2013). Social meaning of ambiguous sounds influences retrospective duration judgments. Psychological Science, 24, 1060-1062. (if=6.128, ci=18)

9. Raffone, A., Srinivasan, N., & van Leeuwen, C. (2014). The interplay of attention and consciousness in visual search, attentional blink and working memory consolidation. Philosophical Transactions of the Royal Society of London B: Biological Sciences, 369(1641):20130215. (if=5.666, ci=33)

10. Srinivasan, N., & Singh, A. (2017). Concentrative meditation influences visual awareness: A study with color afterimages. Mindfulness, 8, 17-26. (if=3.692, ci=7)

359

TIWARI, RAJNARAYAN RAMSHANKAR (b 1970), Director, ICMR-National Institute for Research in Environmental Health, Bhopal


Dr. RR Tiwari, a public health physician by qualification, is currently the Director of the ICMR-National Institute for Research in Environmental Health, Bhopal. His research work is primarily in the field of Occupational, Environmental and Public Health. The nominee through his baseline but pioneering studies on silicosis, asbestosis and coal workers pneumoconiosis has highlighted the magnitude of these occupational lung disorders and also provided interventions for improving the workplace environment to protect the poor workers from acquiring these occupational diseases. He also worked as a nominee member of task force of Government of India for silicosis and asbestosis and member of Supreme Court committee on ship breaking. He also contributed to highlight the health hazards of the working children. The nominee has carried out research in about 30 different occupations. He contributed significantly in capacity building of the nation in occupational health. He highlighted the issue through his series of publication and designed and conducted training programmes to develop and strengthen the manpower in occupational health. As faculty and coordinator for the several courses he also contributed in development of about 800 professionals in occupational health and safety in country. For his remarkable contribution in public health and occupational health he has been awarded prestigious fellowship of IAPSM and IPHA. Recognizing his contribution in the field of Occupational Health, Government of Gujarat awarded him Honorary Associate Fellow in Industrial Health in 2013. He is also an elected Member of NASI (India) and NAMS, India.

Proposer: Dr. Vishwamohan Katoch, Seconder: Dr. Anil Prakash


1. Ganveer GB, Tiwari RR. Injury pattern among non-fatal road traffic accident cases: a cross-sectional study in Central India. Indian Journal of Medical Sciences 2005; 59: 9-12. (if=-, ci=177)

2. Khandekar SP, Bagdey PS, Tiwari RR. Oral cancer and some epidemiological factors: A hospital based study. Indian Journal of Community Medicine 2006; 30(3): 157-159. (if=-, ci=147)

3. Saiyed HN, Tiwari RR. Occupational Health Research in India. Industrial Health 2004; 46(2): 141-148. (if=0.95, ci=97)

4. Tiwari RR. Occupational health hazards among sewage and sanitary workers. Indian Journal of Occupational and Environmental Medicine 2008; 12(3): 112-115. (if=-, ci=57)

5. Zodpey SP, Tiwari RR. Risk factors for haemorrhagic stroke: a case - control study. Public Health 2000; 114: 117 – 122. (if=1.44, ci=55)

6. Tiwari RR, Pathak MC, Zodpey SP. Low back pain among cotton textile workers. Indian Journal of Occupational and Environmental Medicine 2003; 7(1): 27-29. (if=-, ci=52)

7. Tiwari RR, Sharma K, Zodpey SP. Situational analysis of nursing education and work force in India. Nursing Outlook 2013; 61 (3), 129-136 (if=2.28, ci=21)

8. Tiwari RR, Narain R, Patel BD, Makwana IS, Saiyed HN. Spirometric measurements among quartz stone ex-workers of Gujarat, India. Journal of Occupational Health 2003: 45 (2), 88-93 (if=1.2, ci=19)

9. Tiwari RR, Saha A, Parikh JR. Asthenopia (eyestrain) in working children of gem-polishing industries. Toxicology and Industrial Health 2011; 27 (3), 243-247 (if=1.71, ci=13)

10. Tiwari RR, Sharma YK. Respiratory health of female stone grinders with free silica dust exposure in Gujarat, India. International Journal of Occupational and Environmental Health 2008; 14 (4), 280-282 (if=1.195, ci=10)

360

TRIPATHI, MANJARI (b 1968), Professor, Department of Neurology, All India Institute of Medical Sciences (AIIMS)


Prof. Manjari Tripathi graduated her MBBS with distinctions and gold medal. She graduated in Neurology from prestigious National Institute of Mental Health and Neurosciences (NIMHANS) and joined as faculty in Department of Neurology, All India Institute of Medical Sciences (AIIMS). She had contributed in diagnosis and treatment of various neurological disorders like epilepsy, stroke, sleep disorders since 1998. She was awarded the National Institute of Health (NIH-USA) Fellowship, UCLA, in 2005-06 for basic research in Epilepsy. She is also the CO- Principal Investigator- Center of Excellence (COE) for treatment of Epilepsy, a national facility funded by DBT. She has nearly 20 years of experience in epilepsy treatment and an competent team includes neurologists, neuropathologist, basic scientists, physiologist, nuclear medicine, clinical psychology, and neuroradiology. She focuses on research areas like drug resistant epilepsy (DRE), functional neuroimaging and programming of implantable devices in epilepsy. Under her supervision, two new procedures for epilepsy surgery were started - Hemispherotomy and Phase two evaluation with depth and grids to benefit people with DRE. She is principal investigator in various research projects like International pilot study of an internet based platform to run epilepsy trials, rapid diagnostic method for the detection of HLA allele and its association with cutaneous drug reactions in persons with epilepsy, Correlation of Electrophysiological States and Hemodynamic changes during simultaneous EEG-fMRI in Intractable Epilepsy, Cognitive Studies of Language and Memory as Preoperative Evaluation in Patients with DRE. Her landmark article on surgery outcomes in children with DRE was published in NEJM.

Proposer: Prof. N.R. Jagannathan, Seconder: Prof. Subrata Sinha


1. Dwivedi R, Ramanujam B, Chandra PS, Sapra S, Gulati S, Kalaivani M, Garg A, Chandra SB, Tripathi M, Dwivedi SN, Sagar R, Sarkar S, Tripathi M. (Corresponding author)Surgery for drug resistant epilepsy in children. (2017) New Engl J Med. 377:1639-1647(if=79.406 , ci=50)

2. Kumar S, Ramanujam B, Chandra PS, Dash D, Mehta S, Anubha S, Appukutan R, Rana MK, Tripathi M [corresponding author]. Randomized controlled study comparing the efficacy of rapid and slow withdrawal of antiepileptic drugs during long-term video-EEG(if=5.295 , ci=14)

3. Srivastava A, , Banerjee Dixit A, Paul D, Tripathi M, Sarkar C, Chandra PS, Banerjee J. Comparitive analysis of cytokine/chemokine regulatory networks in patients with hippocampal sclerosis and focal cortical dysplasia Sci Rep. Nature (2017) 7:15 (if=4.122, ci=14)

4. Banerjee J, Banerjee Dixit A, Srivastava A, Ramanujam B, Kakkar A, Sarkar C, Tripathi M, Chandra PS. Altered glutamatergic tone reveals two distinct resting state networks at the cellular level in hippocampal sclerosis. Sci Rep (Nature). (2017) 7( (if=4.122, ci=14)

5. Chandra PS, Kurwale NS, Chibber SS, Banerjee J, Dwivedi R, Garg A, Bal C, Tripathi M, Sarkar C, Tripathi M. [corresponding author] Endoscopic-Assisted (Through a Mini Craniotomy) Corpus Callosotomy Combined With Anterior, Hippocampal, and Posteri (if=3.6, ci=7)

6. Chandra PS, Kurwale N, Garg A, Dwivedi R, Malviya SV, Tripathi M.[corresponding author] Endoscopy-assisted interhemispheric transcallosal hemispherotomy: preliminary description of a novel technique. Neurosurgery (Official journal of Congress of N (if=3.6, ci=7)

7. Chandra PS, Vaghania G, Bal CS, Tripathi M, Kuruwale N, Arora A, Garg A, Sarkar C, Diwedi R, Malviya S, Padma V, Tripathi M [corresponding author]. Role of concordance between ictal-subtracted SPECT and PET in predicting long-term outcomes after (if=2.491, ci=4)

8. Tripathi M, Garg A, Gaikwad S, Bal CS, Chitra S, Prasad K, Dash HH, Sharma BS, Chandra PS. Intra-operative electrocorticography in lesional epilepsy. Epilepsy Res. 2010, 89(1):133-41 (if=2.491, ci=4)

9. Chandra PS, Bal C, Garg A, Gaikwad S, Prasad K, Sharma BS, Sarkar C, Singh MB, Padma VM, Tripathi M [corresponding author] Surgery for medically intractable epilepsy due to postinfectious etiologies. Epilepsia. (2010). 51(6):1097-100 (if=5.295, ci=25)

10. Thapa A, Chandra PS, , Sinha S, Sreenivas V, Bhawani S. Sharma and Tripathi M. “Post-traumatic seizures—A prospective study from a tertiary level trauma center in a developing country. Seizure- European Journal of Epilepsy 2010; 19, (4): 211-216 (if=2.05, ci=13)

361

AHMAD, FARHAN JALEES (b 1965), Professor and Dean, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi


Prof. Farhan Jalees Ahmad has 26 years of experience in Research and Teaching through his fruitful association with Ranbaxy Research Laboratories for six years as Scientist. His domain research includes development, scale-up, technology transfer and launching of pharmaceutical products. He is working in the area of Nanomedicine for the last 15 years. He has developed Technology for the preparation of stable Nano DPI with a lung deposition of more than 60% proven clinically in patients of COPD. Products based on this technology have been successfully transferred to Defense Services and are in use in the Armed Forces after approval by DCGI. A total of fourteen products are transferred to Defense Services for use in the Armed Forces He has received research funding of 5.5 crores from National agencies like DBT, CCRUM, AYUSH, UGC, DST and International agencies like FIP and OPCW etc. ] He has recieved Young Scientist Fast Track Award from DST, Scientist of the Year-2005 from NESA, UGC Research Award 2011, Bharat Jyoti Award 2011, Pharma Ratan Award 2017 and ABAP Senior Scientist Award 2017. He has a US patent, Two PCTs and 24 Indian patents. He has published more than 300 research and review papers, 12 Book chapters, 9 books, He has a total citations of 9000 with H Index of 42 and i-10 index of 200. He has guided around 35 M.Pharm students and about 43 PhD scholars. I strongly recommend his candidature as a Fellow of NASI.

Proposer: Prof. Seyed Ehtesham Hasnain, Seconder: Prof. Ahmed Kamal


1. Raisuddin Ali, G.K. Jain, Zeenat Iqbal, Sushma Talegaonkar, P. Pandit, S. Sule, G. Malhotra, R.K. Khar, A. Bhatnagar, Farhan J. Ahmad, 2009 “Development and clinical trial of nano atropine sulfate dry powder inhaler as a novel organophosphorous poisoning antidote”, Nanomed- Nanotechnol. 5(1), 55–63. (if=6.93, ci=34)

2. Bhavna, Farhan J. Ahmad, Gaurav Mittal, Gaurav K. Jain, Geena Malhotra, Roop K. Khar, Aseem Bhatnagar, 2009 “Nano-salbutamol dry powder inhalation: A new approach for treating broncho-constrictive conditions”, Eur. J. Pharm. Biopharm., 71(2), 282-291. (if=3.157, ci=70)

3. A Hussain, VK Singh, OP Singh, K Shafaat, S Kumar, FJ Ahmad, 2016 “Formulation and optimization of nanoemulsion using antifungal lipid and surfactant for accentuated topical delivery of Amphotericin B, Drug Delivery, 1-10, Volume 23, 2016 - Issue 8(if=6.402, ci=11)

4. Neha Mallick, M Anwar, M Asfer, Syed H Mehdi, M Moshahid Alam Rizvi, S Talegaonkar, Farhan Jalees Ahmad, 2016 “Chondroitin sulfate-capped super-paramagnetic iron oxide nanoparticles as potential carriers of doxorubicin hydrochloride” Carbohydrate Polymers, Volume 151, 20, Pages 546-556. (if=4.811, ci=10)

5. M Anwar, S Akhter, N Mallick, S Mohapatra, S Zafar, MMA Rizvi, A Ali, Farhan J Ahmad, 2016 “Enhanced anti-tumor efficacy of paclitaxel with PEGylated lipidic nanocapsules in presence of curcumin and poloxamer: In vitro and in vivo studies” Pharmacological Research 113, 146-165 (if=4.48, ci=09)

6. Z. Naz, Farhan J Ahmad 2015 “Curcumin-loaded colloidal carrier system: formulation optimization, mechanistic insight, ex vivo and in vivo evaluation” International journal of Nanomedicine 10, 4293 (if=4.3, ci=20)

7. S Fatima, Z Iqbal, AK Panda, M Samim, S Talegaonkar, FJ Ahmad 2018 “Polymeric nanoparticles as a platform for permeability enhancement of class III drug Amikacin” Journal Colloids and Surfaces B: Biointerfaces 169, 206-213, (if=4.294, ci=nil)

8. M Anwar, I Ahmad, MH Warsi, S Mohapatra, N Ahmad, S Akhter, A Ali, 2015 “Experimental investigation and oral bioavailability enhancement of nano-sized curcumin by using supercritical anti-solvent process” European Journal of Pharmaceutics and Biopharmaceutics, 96, 162-172, (if=4.159, ci=16)

9. M Anwar, M Asfer, AP Prajapati, S Mohapatra, S Akhter, A Ali, FJ Ahmad (2014), Synthesis and in vitro localization study of curcumin-loaded SPIONs in a micro capillary for simulating a targeted drug delivery system. International journal of pharmaceutics 468 (1), 158-164. (if=4.09, ci=14)

10. Iqbal Ahmad, S Akhter, Mohammed Anwar, Sobiya Zafar, Rakesh Kumar Sharma, Asgar Ali, Farhan Jalees Ahmad, 2017 “Supercritical anti-solvent technique assisted synthesis of thymoquinone liposomes for radioprotection: Formulation optimization, in-vitro and in-vivo studies” International Journal of Pharmaceutics, Volume 523(1)398-409, (if=3.649, ci=02)

362

BALASUBRAMANYAM, MUTHUSWAMY (b 1960), Dean of Research & Senior Scientist, Madras Diabetes Research Foundation, Chennai


The most innovative contribution of the nominee is that his molecular medicine work has unraveled ‘the clinical significance and subclinical relevance of systemic and cellular biomarkers in patients with Type 2 diabetes and its vascular complications’. Balu’s research contributions include: Liquid-biopsy potential of exosomal microRNAs to predict the risk of diabetic kidney disease; Accelerated aging in diabetes as evidenced by telomere shortening; identification of circulatory miRNAs of ‘Asian Indian Phenotype’; identification of ‘druggable’ target epigenetic signature in type 2 diabetes; scientific evaluation of probiotics and herbals with pathway specific mode of action(s); demonstration of detrimental effects of high-fructose diet & endoplasmic reticulum (ER) stress pathway as novel drug target. He has set up the human skeletal muscle and human retinal endothelial cell culture to perform molecular investigations. His present research is linked to several aspects of molecular medicine (transcriptomics, epigenomics, proteomics, metabolomics, metagenomics as well as exposomics) with directionality towards identification of novel drug targets / biomarkers for personalized or precision medicine. He also works on the molecular mechanisms of exercise/yoga lifestyle intervention benefits. Balu serves as an expert member in several task forces and committees. Besides an active researcher, he also serves as a Science Communicator. He is a strong supporter of all components of INSPIRE programs and served as mentor for > 40 INSPIRE camps. He has been serving as mentor for students of IASc-INSA-NASI Summer Research Fellowship and popularizing the concept of “Borderless Biology & Converging Science” through his frequent lectures to the students.

Proposer: Dr. V.Mohan, Seconder: Dr. S.P.Thyagarajan


1. Prabu P, Rome S, Sathishkumar C, Gastebois C, Meugnier E, Mohan V, Balasubramanyam M. MicroRNAs from urinary extracellular vesicles are non-invasive early biomarkers of diabetic nephropathy in type 2 diabetes patients with the 'Asian Indian phenotype'. Diabetes Metab. 2018 Aug 27. pii: S1262-3636(18)30161-7. doi: 10.1016/j.diabet.2018.08.004. (if=3.744, ci=4)

2. Sathishkumar C, Prabu P, Mohan V, Balasubramanyam M. Linking a role of lncRNAs (long non-coding RNAs) with insulin resistance, accelerated senescence, and inflammation in patients with type 2 diabetes. Human Genomics. 2018 Aug 23;12(1):41. doi: 10.1186/s40246-018-0173-3. (if=3.50, ci=3)

3. Sathishkumar C, Prabu P, Balakumar M, Lenin R, Prabu D, Anjana RM, Mohan V & M.Balasubramanyam. Augmentation of histone deacetylase 3 (HDAC3) epigenetic signature at the interface of proinflammation and insulin resistance in patients with Type 2 Diabetes. Clinical Epigenetics, 2016, 24;8:125. (if=6.091, ci=23)

4. Balakumarm M, Prabhu D, Sathishkumar C, Prabu P, Rokana N, Ramesh Kumar, Raghavan S, Avinash Soundarajan, Grover S, Batish V.K, Mohan V and Balasubramanyam M. Improvement of glucose tolerance and insulin sensitivity by probiotic strains of Indian gut origin in high-fat diet fed C57BL/6J mice. European Journal of Nutrition, 2018, Feb;57(1):279- (if=4.370, ci=18)

5. Prabu P, Rome S, Sathishkumar C, Aravind S, Mahalingam B, Shanthirani CS, Gastebois C, Villard A, Mohan V, Balasubramanyam M. Circulating MiRNAs of 'Asian Indian Phenotype' Identified in Subjects with Impaired Glucose Tolerance and Patients with Type 2 Diabetes. PLoS One. 2015 May 28;10(5):e0128372. (if=3.234, ci=23)

6. Lenin R, Sankaramoorthy A, Mohan V & M.Balasubramanyam. Altered immuno-metabolism at the interface of increased Endoplasmic reticulum (ER) stress in patients with type 2 diabetes. Journal of Leukocyte Biology 2015;98(4):615-22 (if=4.289, ci=27)

7. Korwar AM, Vannuruswamy G, Jagadeeshaprasad MG, Jayramaiah RH, Bhat S, Regin BS, Ramaswamy S, Giri AP, Mohan V, Balasubramanyam M, Kulkarni MJ. Development of diagnostic fragment ion library for glycated peptides of human serum albumin: targeted quantification in prediabetic, diabetic and microalbuminuria plasma by PRM, SWATH & MSE. Mol Cell Pro (if=6.540, ci=29)

8. Balasubramanyam M, Aravind S, Gokulakrishnan K, Prabu P, Sathishkumar C, Ranjani H and Mohan, V. Impaired miR-146a expression links subclinical inflammation and insulin resistance in type 2 diabetes. Mol Cell Biochem. 2011 351(1-2):197-205 (if=2.561, ci=164)

9. Adaikalakoteswari A, Balasubramanyam M and Mohan V. Telomere shortening occurs in patients with Type 2 diabetes. Diabetic Medicine, 22, 1151–1156, 2005. (if=3.132, ci=170)

10. Balasubramanyam M, Rohowsky-Cochan C, Reeves JP and Gardner JP. Na+/Ca2+ exchange-mediated calcium entry in human peripheral blood lymphocytes. Journal of Clinical Investigation, 94:2002-2008, 1994. (if=13.251, ci=66)

363

BHARTI, ALOK CHANDRA (b 1974), Professor, University of Delhi, Delhi


Prof. Alok Chandra Bharti’s contributions in understanding molecular mechanisms of carcinogenesis and establishing transcription factors as molecular markers and therapeutic target is outstanding. He is recognized for his sincere efforts in developing novel anti-cancer, and anti-HPV therapeutics. His research on (dys) regulation of transcription factor STAT-3, NF-B and AP-1 during epithelial carcinogenesis elucidated tumor-promoting role of these factors in cell survival, maintenance of stemness and in cancer chemoresistance. These transcription factors have emerged as key prognostic and therapeutic targets in cancer of cervix, head and neck, esophagus and stomach. Dr. Bharti contributed significantly in development of cost-effective HPV diagnostics for early detection of cervical cancer and actively participated in development of uniform international standards for HPV DNA diagnostics coordinated by WHO, Geneva. His ground-breaking work on STAT3 has received international recognition by inclusion of STAT3 in developing fluorescent in-situ hybridization (FISH)-based detection of HPVE6/E7 for perfect screening of HSILs+ lesions. His research has tremendous translational value for early diagnosis, progression and prognosis of cervical cancer.

Proposer: Prof. Bhudev C. Das, Seconder: Prof. Lalit Kumar


1. Bhat A, Sharma A, Bharti AC## (2018). Upstream Hedgehog signaling components are exported in exosomes of cervical cancer cell lines. Nanomedicine (Lond)13(17):2127-2138. PMID: 30265222 (if=IF2017 – 5.005, ci=NEW)

2. Tyagi A, Vishnoi K, Mahata S, Kaur H., Srivastava Y, Roy BG, Das BC, and Bharti AC## (2017) Cervical Cancer Stem Cells Manifest Radioresistance: Association with Upregulated AP-1 Activity. Sci Rep 7(1):4781. (if=IF2017 – 4.122, ci=7)

3. Verma, G., Vishnoi, K., Tyagi, A., Jadli, M., Singh, T., Goel, A., Sharma, A., Agarwal, K., Prasad, S. C., Pandey, D., Sharma, S., Mehrotra, R., Singh, S. M. and Bharti, A. C. ## (2017). Characterization of key transcription factors as molecular signatures of HPV-positive and HPV-negative oral cancers. Cancer Med 6(3): 591-604. (if=IF2016 – 3.362, ci=11)

4. Vishnoi, K., Mahata, S., Tyagi, A., Pandey, A., Verma, G., Jadli, M., Singh, T., Singh, S. M. and Bharti, A.C. ## (2016). Cross-talk between Human Papillomavirus Oncoproteins and Hedgehog Signaling Synergistically Promotes Stemness in Cervical Cancer Cells. Sci Rep 6: 34377. (if=IF2017 – 4.122, ci=10)

5. Vishnoi K, Mahata S, Tyagi A, Pandey A, Verma G, Jadli M, Singh T, Singh SM, Bharti A.C.##. (2016) Human papillomavirus oncoproteins differentially modulate epithelial-mesenchymal transition in 5-FU-resistant cervical cancer cells. Tumour Biol. 37(10):13137-13154. (if=IF2016 – 3.65, ci=7)

6. Tyagi A, Vishnoi K, Mahata S, Verma G, Srivastava Y, Masaldan S, Roy BG, Bharti A.C.##, Das BC. (2016) Cervical cancer stem cells selectively overexpress HPV oncoprotein E6 that controls stemness and self-renewal through upregulation of HES1. Clin Cancer Res. 22(16):4170-8. (if=IF2017 – 10.119, ci=28)

7. Shishodia, G., Shukla, S., Srivastava, Y., Masaldan, S., Mehra, S. Bhambhani, S., Sharma, S. Mehrotra, R., Das, B. C. and Bharti, A.C.## (2015). Alterations in microRNAs miR-21 and let-7a correlate with aberrant STAT3 signaling and downstream effects during cervical carcinogenesis. Mol Cancer. 14: 116. (if=IF2017 – 7.776, ci=34)

8. Shishodia, G., Verma, G., Srivastava, Y., Mehrotra, R., Das, B. C. and Bharti, A.C.## (2014). Deregulation of microRNAs Let-7a and miR-21 Mediate Aberrant STAT3 Signaling during Human Papillomavirus-induced Cervical Carcinogenesis: Role of E6 Oncoprotein. BMC Cancer. 14(1): 996. (if=IF2016 – 3.288, ci=36)

9. Shukla, S., Mahata, S., Shishodia, G., Pandey, A., Tyagi, A., Vishnoi, K., Basir, S. F., Das, B. C. and Bharti, A. C.## (2013). Functional regulatory role of STAT3 in HPV16-mediated cervical carcinogenesis. PLoS One 8(7): e67849. (if=IF2017 – 2.766, ci=45)

10. Shukla, S., Shishodia, G., Mahata, S., Hedau, S., Pandey, A., Bhambhani, S., Batra, S., Basir, S. F., Das, B. C. and Bharti, A. C.## (2010). Aberrant expression and constitutive activation of STAT3 in cervical carcinogenesis: implications in high-risk human papillomavirus infection. Mol Cancer 9: 282. (if=IF2017 – 7.776, ci=76)

364

CHANDRA, PODDIPEDI SARAT (b 1968), Professor, Department of Neurosurgery, All India Institute of Medical Sciences (AIIMS), New Delhi


Prof PS Chandra graduated his MBBS with honors, distinction, gold medals. He graduated his neurosurgery from prestigious National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore. He joined as faculty at AIIMS, New Delhi in 1998 and is currently Professor at the Department of Neurosurgery. Over his tenure at AIIMS, he has operated a large number of surgeries (>25,000) and has contributed to the scientific literature by publishing large number of papers in National and International peer reviewed journals. He is also an eminent teacher and has delivered over hundreds of lectures nationally and internationally. His principal areas of interest include epilepsy and related networks and epilepsy imaging and surgery. His other interest is the craniovertebral junction anomalies. He has a multispeciality team of epileptologists, neurologists, electrophysiologist and basic scientists. He has established Center of Excellence for Epilepsy (first of its kind in India) which provides state of art surgical treatment for patients with drug resistant epilepsy and to develop research paradigms by correlating imaging, brain mapping, MEG studies along with the molecular, cellular and electrophysiological studies to find out the nature of epileptogenic networks and also the possible biomarkers for epilepsy. He has developed new surgical techniques like multi-modal imaging for epilepsy surgery, endoscopic hemispherotomy, endoscopic corpus callosotomy with commissurotomy, DCER technique for cranio-vertebral junction anomalies, absolute alcohol embolization for vertebral hemangioma with short segment fixation and disposable endoscopic carpal tunnel syndrome. His pioneering research on 2 independent neuronal networks in hippocampal sclerosis has impact on modifying surgical strategies.

Proposer: Prof. N.R. Jagannathan , Seconder: Prof. Chitra Sarkar


1. Dwivedi R, Ramanujam B, Chandra PS, Sapra S, Gulati S, Kalaivani M, Garg A, Chandra SB, Tripathi M, Dwivedi SN, Sagar R, Sarkar S, Tripathi M. Surgery for drug resistant epilepsy in children. (2017) New Engl J Med. 377:1639-1647 (if=79.406 , ci=50)

2. Dixit AB, Sharma D, Tripathi M, Srivastava A, Paul D, Prakash D, Sarkar C, Kumar K, Banerjee J, Chandra PS (corresponding author). Genome wide DNA methylation and RNA seq analyses aberrant signaling pathways in Focal Cortical Dysplasia Type II. Sc (if=4.122, ci=14)

3. Banerjee J, Banerjee Dixit A, Srivastava A, Ramanujam B, Kakkar A, Sarkar C, Tripathi M, Chandra PS (corresponding author). Altered glutamatergic tone reveals two distinct resting state networks at the cellular level in hippocampal sclerosis. 2017 (if=4.122, ci=14)

4. Baumgartner JE, Blount JP, Blauwblomme T, Chandra PS (corresponding author). Technical descriptions of four hemispherectomy approaches: From the Pediatric Epilepsy Surgery Meeting at Gothenburg 2014. (2017) Epilepsia., 1:46-55. (if=5.295, ci=20)

5. Dixit AB, Banerjee J, Srivastava A, Tripathi M, Sarkar C, Kakkar A, Jain M, Chandra PS (corresponding author). RNA-Seq analysis of hippocampal tissues reveals novel candidate genes for drug refractory epilepsy in patients with MTLE-HS. 2016 Genomi (if=3.2, ci=12)

6. Chandra PS, Kurwale NS, Chibber SS, Banerjee J, Dwivedi R, Garg A, Bal C, Tripathi M, Sarkar C, Tripathi M. Endoscopic-Assisted (Through a Mini Craniotomy) Corpus Callosotomy Combined With Anterior, Hippocampal, and Posterior Commissurotomy in Len (if=3.6, ci=7)

7. Banerjee J, Banerjee Dixit A, Tripathi M, Sarkar C, Gupta YK, Chandra PS [corresponding author]. Enhanced endogenous activation of NMDA receptors in pyramidal neurons of hippocampal tissues from patients with mesial temporal lobe epilepsy: A mecha (if=2.491, ci=4)

8. Chandra PS, Prabhu M, Goyal N, Garg A, Chauhan A, Sharma BS. Distraction, Compression, Extension, and Reduction Combined With Joint Remodeling and Extra-articular Distraction: Description of 2 New Modifications for Its Application in Basilar Invag (if=3.6, ci=19)

9. Chandra PS, Kurwale N, Garg A, Dwivedi R, Malviya SV, Tripathi M. Endoscopy-assisted interhemispheric transcallosal hemispherotomy: preliminary description of a novel technique. 2015 Neurosurgery (Official journal of Congress of Neurological Surge(if=3.6, ci=19)

10. Chandra PS, Bal C, Garg A, Gaikwad S, Prasad K, Sharma BS, Sarkar C, Singh MB, Padma VM, Tripathi M. Surgery for medically intractable epilepsy due to postinfectious etiologies. 2010 Epilepsia. 51(6):1097-100 (if=5.295, ci=29)

365

CHOWDHARY, ANURADHA (b1969) Professor, Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110 007


Prof A. Chowdhary is renowned for her outstanding original contributions that have significantly advanced the knowledge of fungal infections in India. Her work on antifungal resistance in Aspergillus and Candida is recognized globally. She reported for the first time about multi drug resistant Candida auris in several hospitals in India and highlighted the problem of its misidentification and demonstrated molecular mechanisms of antifungal resistance in azoles and echinocandins (Emerg. Infect. Dis. 2013; 19: 1670-3; J Clin Microbiol. 2015; 53: 1823-30; Clin Microbiol Infect. 2016; 22: 277.e1-9 J Antimicrob Agents & Chemother 2018; 73:891-899). The therapeutic option for infection with this yeast is limited was shown in her publications highlighting that all three classes of antifungals available for therapy are ineffective in several patients. Also, whole genome sequence data of Indian isolates pointed to the occurrence of highly related clone, suggesting that its emergence in India is a recent phenomenon (New Microbes and New Infect. 2016; 13:77-82; Clin Infect Dis. 64:134-140) Following her findings, presently, C.auris is considered to be an emerging super bug worldwide prompting US CDC, European CDC and Public Health London to issue alerts regarding its notification. Her work on invasive aspergillosis due to Aspergillus fumigatus, the commonest mould infection associated with high mortality highlighted for the first time the problem of multi-azole resistance in A. fumigatus in India in azole naïve patients (J Antimicrob Chemother 2012,67;362-6; Front. Microbiol 2016; 6: 1-10). This emergence of azole-resistance in A. fumigatus significantly impacts the therapeutic role of azoles in aspergillosis as it rules out the use of oral antifungals, which are the treatment of choice in these patients. (PLoS Pathog. 2013; 9: 10: e1003633) Reports of her extensive environmental surveys pointed out those azole fungicides in the environment induce cross-resistance to medical azoles in A. fumigatus. (PloS ONE. 2012; 7:e52871; J Antimicrob Chemother 2016; 69: 555-7 Mbio. 2015; 6: pii: e00536-15.). Recognizing her significant work on antifungal resistance, she was nominated as expert member of International Expert Opinion to deliberate on treatment of azole resistant aspergillosis (Drug Res Update. 2015; 21-22: 30-40). She is a Fellow of American Academy of Microbiology and Infectious Disease Society of America, and led group in 2013-14 for development of ESCMID & ECMM guidelines for diagnosis and management of diseases caused by black fungi (Clin Microbiol Infect. 2014; 20: S3: 47-75).

Proposer: Prof. Amit P. Sharma, Seconder: Prof. S.E. Hasnain Ten Best Publications: 1. Chowdhary A, Kathuria S, Randhawa HS, Gaur SN, Klaassen CH, Meis JF. 2012. Isolation of multiple-triazole- resistant Aspergillus fumigatus strains carrying the TR 34 /L98H mutations in the cyp51A gene in India. J Antimicrob. Chemother. 67: 362-366. (If= 5.313; Ci= 150) 2. Chowdhary A, Kathuria S, Xu J, Sharma C, Sundar G, Singh PK, Gaur SN, Hagen F, Klaassen CH, Meis JF. 2012. Clonal expansion and emergence of environmental multiple-triazole- resistant Aspergillus fumigatus strains carrying the TR 34 /L98H mutations in the cyp51A gene in India. PloS ONE. 7:e52871. (If= 2.806; Ci= 100) 3. Chowdhary A, Sharma C, Duggal S, Agarwal K, Prakash A, Singh PK, Jain S, Kathuria S, Randhawa HS, Hagen F, Meis JF. 2013. New clonal strain of Candida auris, Delhi, India. Emerg. Infect. Dis. 10: 1670-3. (If= 8.22; Ci= 94) 4. Chowdhary A, Kathuria S, Xu J, Meis JF. 2013. Emergence of azole resistant Aspergillus fumigatus strains due to agricultural azole use creates an increasing threat to human health. PLoS Pathog. 9: 10e1003633 (If= 7; Ci= 142) 5. Chowdhary A, Sharma C, Kathuria S, Hagen F, Meis JF. 2014. Azole-resistant Aspergillus fumigatus with the environmental TR 46 /Y121F/T289A mutation in India. J Antimicrob Chemother. 69: 555-7. (if 5.313; Ci= 66) 6. Chowdhary A, Sharma C, Kathuria S, Hagen F, Meis JF. 2015. Prevalence and mechanism of triazole resistance in Aspergillus fumigatus in a referral chest hospital in Delhi, India and an update of the situation in Asia. Front. Microbiol. 6: 1-10. (If= 4.076; Ci= 45) 7. Abdolrasoulia A, Rhodes J, Beale MA, Hagen F, Rogers TR, Chowdhary A, Meis JF, Armstrong-James D, Fisher MC. 2015. Genomic context of azole-resistance mutations in Aspergillus fumigatus determined using whole-genome sequencing. Mbio. 6: pii: e00536-15. doi: 10.1128/mBio.00536-15. (If= 6.956; Ci= 46) 8. Kathuria S, Singh PK, Sharma C, Prakash A, Masih A, Kumar A, Meis JF, Chowdhary A. 2015. Multidrug resistant Candida auris misidentified as C. haemulonii: Characterization by Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS), DNA sequencing and its antifungal susceptibility profile variability by VITEK-2, CLSI-Broth Microdilution and E-test method. J Clin Microbiol. 53: 1823-30. (If= 4.232; Ci= 103) 9. Prakash A, Sharma C, Singh A, Singh PK, Kumar A, Hagen F, Govender PN, Colombo AL, Meis JF, Chowdhary A. 2016. Evidence of genotypic diversity among Candida auris isolates by multilocus sequence typing, matrix-assisted laser desorption ionization-time of flight mass spectrometry and amplified fragment length polymorphism. Clin Microbiol Infect. 22(3): 277.e1-9. doi: 10.1016/j.cmi.2015.10.022. (If= 5.292, Ci= 38) 10. Chowdhary A, Sharma C, Meis JF. 2017. Candida auris: A rapidly emerging cause of hospital acquired multi-drug resistant fungal infections globally. PLoS Pathog. 135:e1006290. doi: 10.1371/journal.ppat.1006290. eCollection 2017. (If= 7; Ci= 41)

366

DAS SARMA, JAYASRI (b 1965), Professor, Indian Institute of Science Education and Research, Kolkata


Jayasri Das Sarma works in the field of neurovirology and neuroimmunology. She has made significant contribution in our current understanding of viral-induced demyelination in an animal model of human demyelinating disease, Multiple Sclerosis (MS). Her work revealed that Mouse Hepatitis Virus (MHV) induced demyelination is concurrent with axonal loss due to microglia-mediated myelin stripping and is not driven by B and T cells or made to order antibodies but the robust upregulation of innate immune mediators. This is different from the conventional autoimmune model of MS and provides a platform to study the mechanism of direct viral induced mechanism of demyelination and axonal loss. Her studies demonstrated that panglial gap junction intercellular communication through Connexin 43/47 has a pivotal role in disruption of myelin which made a paradigm shift in the understanding of the role of astrocytic metabolic coupling in myelination. While she is interested in host factors responsible for the myelin pathology her comprehensive studies to understand the MHV induced cell and cell-cell fusion interactions presents new insights into the virus-induced fusion mechanism and its role in neuropathogenesis which is of general interest in the field of virus-host interaction. The presence of two consecutive proline in fusion peptide of demyelinating MHV strain promote a more ordered, compact and rigid structure of spike protein. In addition, she is attempting to examine Arsenic exposure on humans as this has huge societal relevance. Her findings have revealed that Arsenic binding to Connexin 43 alters cell to cell communication and tissue homeostasis.

Proposer: Dr. Akhil C. Banerjea, Seconder: Dr. Mitali Chatterjee


1. Das Sarma, J.*, Iacono, K., Gard, L., Marek, R., Kenyon, L. C., Koval, M., & Weiss, S. R. (2008). “Demyelinating and Nondemyelinating Strains of Mouse Hepatitis Virus Differ in Their Neural Cell Tropism.” Journal of Virology, 82(11), 5519-5526. doi:10.1128/jvi.01488-07. (if=4.663, ci=26)

2. Shindler, K. S., Kenyon, L. C., Dutt, M., Hingley, S. T., & Das Sarma, J.* (2008). “Experimental Optic Neuritis Induced by a Demyelinating Strain of Mouse Hepatitis Virus.” Journal of Virology, 82(17), 8882-8886. doi:10.1128/jvi.00920-08. (if=4.663, ci=26)

3. Das Sarma, J.*, Kenyon, L. C., Hingley, S. T., & Shindler, K. S. (2009). “Mechanisms of Primary Axonal Damage in a Viral Model of Multiple Sclerosis.” Journal of Neuroscience, 29(33), 10272-10280. doi:10.1523/jneurosci.1975-09.2009. (if=5.988, ci=42)

4. Biswas, K., & Das Sarma, J.* (2013). “Effect of Microtubule Disruption on Neuronal Spread and Replication of Demyelinating and Nondemyelinating Strains of Mouse Hepatitis Virus In Vitro.” Journal of Virology, 88(5), 3043-3047. doi:10.1128/jvi.02545-13. (if=4.663, ci=7)

5. Kenyon, L. C., Biswas, K., Shindler, K. S., Nabar, M., Stout, M., Hingley, S. T., Grinspan, J. B. & Das Sarma, J.* (2015). “Gliopathy of Demyelinating and Non-Demyelinating Strains of Mouse Hepatitis Virus.” Frontiers in Cellular Neuroscience, 9. doi:10.3389/fncel.2015.00488. (if=4.555, ci=3)

6. Basu, R., Banerjee, K., Bose, A., & Das Sarma, J.* (2015). “Mouse Hepatitis Virus Infection Remodels Connexin43-Mediated Gap Junction Intercellular Communication In Vitro and In Vivo.” Journal of Virology, 90(5), 2586-2599. doi:10.1128/jvi.02420-15. (if=4.663, ci=5)

7. Basu, R., Bose, A., Thomas, D., & Das Sarma, J.* (2017). “Microtubule-assisted altered trafficking of astrocytic gap junction protein connexin 43 is associated with depletion of connexin 47 during mouse hepatitis virus infection.” Journal of Biological Chemistry, 292(36), 14747-14763. doi:10.1074/jbc.m117.786491. (if=4.010)

8. Bose, A. Basu, R ., Maulik, M., Das Sarma, J.*(2017). Loss of Cx43-Mediated Functional Gap Junction Communication in Meningeal Fibroblasts Following Mouse Hepatitis Virus Infection. Molecular Neurobiology;1-14; https://doi.org/10.1007/s12035-017-0861-3. (if=6.19)

9. Hussain A, Das Sarma S, Babu S, Pal D, Das Sarma J. Interaction of arsenic with gap junction protein connexin 43 alters gap junctional intercellular communication. Biochim Biophys Acta. 2018 Jul 19;1865(10):1423-1436. doi: 10.1016/j.bbamcr.2018.07.014.(if=3.438)

10. Manmeet Singh, Abhinoy Kishore, Dibyajyoti Maity, Punnepalli Sunanda, Bankala Krishnarjuna, Sreeparna Vappala, Srinivasarao Raghothama, Lawrence C. Kenyon, Debnath Pal and Jayasri Das Sarma.*(2019).A proline insertion-deletion in the spike glycoprotein fusion peptide of mouse hepatitis virus strongly alters neuropathologyJ. Biol. Chem. jbc.RA118.00 (if=4.010)

367

DAS, MADHUSUDAN (b 1965), Professor and Dean of Science, University of Calcutta, Kolkata


Prof. Madhusudan Das is an outstanding faculty member and scientific administrator of the University of Calcutta. His long term research questions are interdisciplinary and address genetic aspects of different pathophysiological conditions coupled to translational perspective. In 25 years of research, Prof. Das has significantly contributed towards unravelling altered genetic signatures associated with different diseases, such as, .hypothyroidism, non-syndromic hearing loss, diabetes, gastric cancer, kidney stone disease. He has discovered unique genomic signatures for early detection of diseases that are relevant for the Indian population. Using samples drawn from West Bengal and Mizoram, he has validated these signatures. He has contributed to the understanding of. inter-individual variability of drug efficacy in type II diabetes mellitus. His findings have provided novel markers of better treatment regime. Prof. Das’s scientific journey starting as ‘Scientist’ of Indian Institute of Chemical Biology to the ‘Dean of Science’ of University of Calcutta is truly remarkable and deserves great appreciation. His scientific dedication, achievement, mentoring and true leadership as the Dean of Science have been phenomenal. His involvement in this long scientific tenure through different national & international projects, personal or collaborative, resulted not only in high impact publications, but also helping the University of Calcutta to maintain its century old scientific accomplishments. I make these statements based on personal knowledge of Dr. Das’s scientific accomplishments. I also wish to state that I have co-authored publications with him. I strongly recommend his candidature for the Fellowship of NASI.

Proposer: Prof. Partha Pratim Majumder, Seconder: Dr. Susanta Roychoudhury


1. Maity B, Chakraborti S, Pramanick A, Saha S, Roy S, Chaudhuri A, Das M, Ghosh S and Stewart A. (2018). Atypical G protein β5 promotes cardiac oxidative stress, apoptosis, and fibrotic remodeling in response to multip Cancer Research 78(2):528-541 (if=9.329)

2. Ghosh S, Bankura B, Ghosh S, Saha ML, Pattanayak AK, Ghatak S, Guha M, Nachimuthu SK, Panda CK, Maji S, Chakraborty S, Maity B, and Das M. (2017). Polymorphisms in ADH1B and ALDH2 genes associated with the increased risk of BMC Cancer, 17:782-793 (if=3.362)

3. Mitra P, Guha M, Ghosh S, Mukherjee S, Bankura B, Pal DK, Maity B, and Das M. (2017). Association of calcitonin receptor gene (CALCR) polymorphism with kidney stone disease in the population of West Bengal, India, Gene, 622:23-28 (if=2.415, ci=1)

4. Ghosh S, Ghosh S, Bankura B, Saha ML, Maji S, Ghatak S, Pattanayak AK, Sadhukhan S, Guha M, Senthil Kumar N, Panda CK, Maity B, and Das M. (2016). Association of DNA Repair and xenobiotic pathway gene polymorphisms . Tumour Biology, 37(7): 9139-9149 (if=3.650, ci=5)

5. Guha M, Bankura B, Ghosh S, Pattanayak AK, Ghosh S, Pal DK, Puri A, Kundu AK, and Das M. (2015). Polymorphisms in CaSR and CLDN14 Genes Associated with Increased Risk of Kidney Stone Disease in Patients from the Eastern Part PLoS One,10(6):e0130790 (if=2.806, ci=9)

6. Adhikary B, Ghosh S, Paul S, Bankura B, Pattanayak AK, Biswas S, Maity B, and Das M.(2015). Spectrum and frequency of GJB2, GJB6 and SLC26A4 gene mutations among nonsyndromic hearing loss patients in eastern part of India. Gene, 573(2): 239-245 (if=2.415, ci=8)

7. Fung MM, Nguyen C, Methani P, Salem RM, Perez B, Thomas B, Das M, Schork NJ, Mahata SK, Ziegle MG, O’Connor DT. (2008). Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation Circulation, 117(4):517-525 (if=19.309, ci=16)

8. Zhang L, Rao F, Zhang K, Khandrika S, Das M, vaingankar SM, Bao X, rana BK, et al. (2007). Discovery of common human genetic variants of GTP Cyclohydrolase1 (GCH1) nitric oxide autonomic activit Journal of Clinical Investigation, 117(9): 2658- 2671 (if=15.32, ci=76)

9. Rao F, Zhang L, Wessel J, Zhang K, Wen G, Kennedy BP, Rana BK, Das M, et al. (2007).Tyrosine hydroxylase, the rate- limiting enzyme in catecholamine biosynthesis: discovery of common human geneti Journal of Clinical Investigation, 117(9): 2658- 2671 (if=19.309, ci=84)

10. Rao F, Wen G, Gayen JR, Das M, Vaingankar SM, Rana BK, et a. (2007) Catecholamine release- inhibitory peptide catestatin (chromogranin A (352- 372)): naturally occurring amino acid variant Gly364Ser causes profound ch Circulation, 115(17): 2271-2281 (if=19.309, ci=115)

368

DIXIT, MADHULIKA (b 1974), Associate Professor, Department of Biotechnology, IIT Madras, Chennai


I have known Dr. Dixit for the last 10 years and her core research interest is to understand mechanisms governing aberrant endothelial function during pre-diabetes and hyperinsulinemia. Since endothelial dysfunction triggers the onset of macro-angiopathy and is accelerated upon metabolic imbalance, despite her basic science approach, her research is relevant for clinical understanding of cardiovascular diseases. She employs primary cultures of umbilical vein derived endothelial cells (HUVECs) and circulating endothelial progenitor cells (EPCs) as cell culture model systems, in addition to performing molecular biology and biochemistry experiments. She further corroborates her mechanistic findings with clinical observations through her medical collaborators. In the past few years she has established a successful research team in Endothelial Biology at IIT Madras which is evident from her peer-reviewed publications in renowned thematic journals such as Arteriosclerosis Thrombosis and Vascular Biology, Journal of Thrombosis and Haemostasis, Diabetes and Vascular Disease Research, and Journal of Nutritional Biochemistry to name a few. Her work demonstrated that chronic hyperinsulinemia as a consequence of insulin resistance, promotes endothelial inflammation by reducing the bio-availability of nitric oxide (NO) due to eNOS uncoupling and increased activity of Arginase-II. This finding was reconfirmed for endothelial cells derived from Gestational Diabetic mothers. Additionally, she reported that the endothelial differentiation and vasculogenic ability of circulating EPCs is attenuated during pre-diabetes, thus delaying the process of vascular repair. Her group has also demonstrated the anti-atherosclerotic effects of Gentiana lutea root extracts, thereby opening the possibility of identifying new drug leads for management of CVD.

Proposer: Dr. G. Bhanu Prakash Reddy, Seconder: Dr. Sathees C. Raghavan


1. Anuradha, S. et.al. (2010) “Angiopoietin-2 levels in glucose intolerance, hypertension, and metabolic syndrome in Asian Indians (Chennai Urban Rural Epidemiology Study-74).” Metabolism Clinical and Experimental, 59(6): 774-9. (if=5.8, ci=22)

2. Nathan, A.A. et.al (2011) "Glucose challenge increases circulating progenitor cells in Asian Indian male subjects with normal glucose tolerance which is compromised in subjects with pre-diabetes: A pilot study.” BMC Endocrine disorders, 11(1):2. (if=2.2, ci=7)

3. Bairagi, S. et.al (2012) "“Glucose induced increase in circulating progenitor cells is blunted in anovulatory subjects.” Human Reproduction, 27(3):844-53. (if=5.02, ci=5)

4. Giri, H. et.al. (2012) "Protein tyrosine phosphatase SHP2 mediates chronic insulin induced endothelial inflammation.” Arteriosclerosis, Thrombosis and Vascular Biology, 32: 1943-1950. (if=6.6, ci=23)

5. Potunuru, U.R. et.al. (2013) "Ellagic acid (EA) inhibits PDGF-BB induced vascular smooth muscle cell proliferation and prevents atheroma formation in streptozotocin-induced diabetic rats.” Journal of Nutritional Biochemistry, 24(11):1830-9. (if=4.5, ci=29)

6. Rushendhiran, K. et.al. (2013) “Inhibition of vascular smooth muscle cell proliferation by Gentiana lutea root extracts.” PLOS One, 8(4): e61393. (if=2.8, ci=25)

7. Giri, H. et.al (2013) “Increased endothelial inflammation, sTie-2 and arginase activity in gestational diabetes.” PLoS One, 8(12): e84546. (if=2.8, ci=13)

8. Nathan, A.A. et.al. (2015) “Impaired glucose tolerance alters functional ability of peripheral blood-derived mononuclear cells in Asian Indian men.” Diabetes and Vascular Disease Research, 12(1): 13-22. (if=2.5, ci=2)

9. Kesavan, R. et.al. (2016) “Gentiana lutea exerts anti-atherosclerotic effects by preventing endothelial inflammation and smooth muscle cell migration.” (2016) Nutrition, Metabolism and Cardiovascular Diseases, 26(4): 293-301. (if=3.7, ci=7)

10. Rathnakumar, K. et.al. (2016) “Angiopoietin-2 mediates thrombin-induced monocyte adhesion and endothelial permeability.” Journal of Thrombosis and Haemostasis, 14(8): 1655-1657. (if=5.3, ci=1)

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369

GARG, PRASHANT (b 1964), Ophthalmologist, L.V. Prasad Eye Institute, Banjara Hills, Hyderabad 500034


Dr. Prashant Garg, MBBS, MS, is an eminent corneal surgeon and researcher, who has effectively combined translational research, in particular infections of the eye and their treatment, with clinical practice. Thought to be among the top 10 corneal surgeons of India, he has been actively involved in what is best described as “bedside to bench and back to bedside”. During the last 20 years, he has focused his research on sight-threatening infection on the eye by microbes- in particular on contact lenses and the cornea- their virulence and drug resistance, diagnosis and treatment of such infections using novel methods. By developing ex vivo models of corneal infections, he has been able to evaluate the efficacy of various diagnostic and therapeutic interventions. Winning grants obtained from the Welcome Trust, Medical Research Council of UK, Newton-Bhabha Fund, and ICMR, he has helped develop (a) a diagnostic contact lens containing specific tags that readily identify gram positive, gram negative bacterial, fungal and such pathogens (thus avoiding the lengthy cell culture based identification) and thus saving time, and (b) using a novel dissolvable polymer micro-needle delivery vehicle to inject besifloxacin into the cornea as an effective treatment mode.

Proposer: Prof. Appa Rao Podile, Seconder: Prof. D. Balasubramanian


1. Bhatnagar S, Saju A, Cheerla KD, Gade SK, Garg P, Venuganti VVK. Corneal delivery of besifloxacin using rapidly dissolving polymeric microneedles. Drug Deliv Transl Res. 2017 Dec 29 (if=3.094)

2. Rathi VM, Thakur M, Sharma S, Khanna R, Garg P. KOH mount as an aid in the management of infectious keratitis at secondary eye care centre. Br J Ophthalmol. 2017 Nov;101(11):1447-1450 (if=3.806)

3. Pinnock A, Shivshetty N, Roy S, Rimmer S, Douglas I, MacNeil S, Garg P. Ex vivo rabbit and human corneas as models for bacterial and fungal keratitis. Graefes Arch Clin Exp Ophthalmol. 2017 Feb;255(2):333-342. (if=2.349)

4. Garg P, Roy A, Sharma S. Endophthalmitis after cataract surgery: epidemiology, risk factors, and evidence on protection. Curr Opin Ophthalmol. 2017 Jan;28(1):67-72. (if=2.920)

5. Sharma S, Balne PK, Motukupally SR, Das S, Garg P, Sahu SK, Arunasri K, Manjulatha K, Mishra DK, Shivaji S. Pythium insidiosum keratitis: clinical profile and role of DNA sequencing and zoospore formation in diagnosis. Cornea. 2015 Apr;34(4):438-4 (if=2.010)

6. Jain R, Garg P, Motukupally SR, Geary MB. Clinico-microbiological review of non-contact-lens-associated acanthamoeba keratitis. Semin Ophthalmol. 2015 Jul;30(4):281-8 (if=1.185)

7. Konda N, Motukupally SR, Garg P, Sharma S, Ali MH, Willcox MD. Microbial analyses of contact lens-associated microbial keratitis. Invest. Optom Vis Sci. 2014 Jan;91(1):47-53. (if=3.303)

8. Garg P. Microsporidia infection of the cornea--a unique and challenging disease. Cornea. 2013 Nov;32 Suppl 1:S33-8 (if=2.010)

9. Vaddavalli PK, Garg P, Sharma S, Sangwan VS, Rao GN, Thomas R. Role of confocal microscopy in the diagnosis of fungal and acathamoeba keratitis. Ophthalmology 2011;118(1):29-35. (if=8.204)

10. Decroos FC, Garg P, Reddy AK, Sharma A, Krishnaiah S, Mungale M, Mruthyunjaya P; Hyderabad Endophthalmitis Research Group. Optimizing Diagnosis and Management of Nocardia Keratitis, Scleritis, and Endophthalmitis: 11-Year Microbial and Clinical O (if=8.204)

370

KANT, SURYA (b 1965), Professor & Head, Department of Respiratory Medicine and Department of Pulmonary & Critical Care (Officiating), KGMU, Lucknow


Dr Surya Kant, Professor and Head, Department of Respiratory Medicine, and Department of Pulmonary & Critical Care (Off.) KGMU, Lucknow has to his credit 14 books, 41 book chapters and 597 research papers. Dr Surya Kant’s article published in an international journal on MDR-TB: An iatrogenic problem is continuously no. 1 article among top 20 articles globally in the domain of TB since 2010. He has guided 151 MD, DNB, PhD and M.Phil students and has supervised 49 research projects and clinical trials. He was conferred the prestigious Lowesche award for his excellent innovation in the field of Asthma. He got the outstanding US patents and innovation (Patent no.US 7,514,105 B2, E-S/1279/2018-DEL). He has been awarded 12 national and international fellowships including prestigious fellowship of American College of Chest Physicians. He is the founder chief editor of Lucknow Medical Journal and member, editorial board and reviewers of many national and international journals. Dr Surya Kant has 28 years of teaching and professional experience and has got many Professional Laurels to his credit. He was the President of Medical Science (including Physiology Section) of Indian Science Congress Association (2013-14) and Indian Chest Society (2016-17). Currently he is the President of Indian College of Allergy Asthma and Applied Immunology (2018-2020), President Elect of National College of Chest Physicians (India). Including fellow of International society of Environmental Botanist. In total 103 State level, National and International prestigious awards to his credit. Including Vigyan Gaurav Award,given by UP Govt. in the Field of Science.

Proposer: Dr. Usha Kant Mishra, Seconder: Prof. R.S. Tripathi


1. Kant S*, A. K. Maurya, R. A. S. Kushwaha, V. L Nag & R Prasad Multi-drug resistant tuberculosis: An iatrogenic problem, Trends Bio Science, 2010; 4; 48-55 (if=1.844, ci=64)

2. B. Gupta, Kant S*, R. Mishra, Subjective global assessment of nutritional status of chronic obstructive pulmonary disease patients on admission, Int. J Tuberc Lung Dis, 2010;4; 500-505 (if=2.61, ci=48)

3. B Gupta, Kant S*, R Mishra, S Verma, Nutritional Status of Chronic Obstructive Pulmonary Disease Patients Admitted in Hospital With Acute Exacerbation, J Clin Med Res 2010;2; 68-74; (if=1.56, ci=42)

4. Shukla RK, Kant S, Bhattacharya S, Mittal B, Association of Genetic polymorphism of GSTT1, GSTM1 and GSTM3 in COPD Patients in a north Indian population. COPD, Journal of Chronic Obstructive Pulmonary Disease, 2011;8;167-172 (if=2.604, ci=77)

5. AK Maurya, Kant S*, VL Nag, RAS Kushwaha, TN Dhole, Trends of anti-tuberculosis drug resistance pattern in new cases and previously treated cases of extrapulmonary tuberculosis cases in referral hospitals in northern India, J Postgrad Med, 2012; 58;185-189(if=1.095, ci=30)

6. AK Maurya, S Kant, VL Nag, RAS Kushwaha, TN Dhole, Detection of 123 bp fragment of insertion element IS6110 Mycobacterium tuberculosis for diagnosis of extra pulmonary tuberculosis. Indian journal of medical microbiology; 2012; 30, 182-186 (if=1.149, ci=33)

7. AK Maurya, AK Singh, M Kumar, J Umrao, S Kant*, VL Nag, Changing patterns and trends of multidrug-resistant tuberculosis at referral centre in Northern India: a 4-year experience Indian journal of medical microbiology;2013; 31:40-46 (if=1.149, ci=25)

8. Pandey H, Fatma F, Yaba ji SM, Kumari M, Tripathi S, Srivastava K, Tripathi D K, Kant S, Srivastava K K, Arora A Biophysical and immunological characterization of the ESX-4 system ESAT-6 family proteins Rv3444c and Rv3445c from Mycobacterium tuberculosis H37Rv Tuberculosis (2018) 109, 85–96, (if=2.9, ci=2)

9. Narain A, Verma AK, Srivastava K, Srivastava KK, Kant S*, IS6110 an Ineluctable molecular marker in clinical isolates of drug resistant tuberculosis, European Journal of Biomedical and Pharmaceutical Sciences (EJBPS); 2017, 4, 644-650. http://www.ejbps.com (if=4.9, ci=2)

10. Pandey H, Tripathi S, Srivastava K, Tripathi DK, Kant S, Srivastava KK, and Arora A, Characterization of Immunodominant Culture Filtrate Proteins Rv1197 and Rv1198 of ESAT-6 family from Mycobacterium tuberculosis H37Rv. Biochimica n biophysica Acta (BBA); 2017;1861, 396-408 (if=5.3, ci=2)

371

KESAVADAS, CHANDRASEKHARAN (b 1965), Professor & Head of Radiology, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram


Dr.C.Kesavadas ,Professor & Head of Radiology at Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, has research focus in the field of magnetic resonance imaging and neuroradiology. He and his team developed protocols for performing clinical functional MRI studies in pre-surgical patients and advanced neuroimaging methods in intractable epilepsy. He and his team evaluated the role of diffusion tensor imaging, susceptibility weighted imaging, perfusion imaging & MR spectroscopy for diagnosis & management of brain tumor, movement disorders, stroke & neurodegenerative diseases, thus bringing many of these newer techniques into clinical realm. His present research is focused on brain connectivity studies using resting state fMRI, brain computer interface & near infra-red spectroscopy. Results of these studies have been published in reputed international journals. He is a well-known teacher in the field of neuroimaging and has been a visiting faculty at several medical institutions and teaching programs in the country. Dr.Kesavadas has research collaborations with technological universities and industry for research & development in the field of medical image processing & machine learning. He has published extensively, with more than 180 publications in reputed indexed journals and has an h-index of 29. He heads or is a member of scientific bodies set up by government and scientific associations. He is editorial board member of several scientific journals. The DBT, Government of India awarded him the National Bioscience Award for Career Development, for his contributions to biosciences, in 2009. He has also received oration award from ICMR.

Proposer: Prof. C.C.Kartha, Seconder: Prof. M. Radhakrishna Pillai


1. Sylaja PN, Radhakrishnan K, Kesavadas C, Sarma PS ( 2004) Seizure Outcome after Anterior Temporal Lobectomy and Its Predictors in Patients with Apparent Temporal Lobe Epilepsy and Normal MRI Epilepsia, 45(7):803–808, 2004 (if=5.295, ci=130)

2. Kesavadas C, Thomas B, Sujesh S, Ashalata R, Abraham M, Gupta AK, Radhakrishnan K.( 2007) Real-time functional MR imaging (fMRI) for presurgical evaluation of paediatric epilepsy. Pediatr Radiol.;37(10):964-74 (if=1.465 , ci=42)

3. Raghavendra S, Ashalatha R, Thomas SV, Kesavadas C (2007) Focal neuronal loss, reversible subcortical focal T2 hypointensity in seizures with a nonketotic hyperglycemic hyperosmolar state. Neuroradiology. ;49(4):299-305 (if=2.093, ci=65)

4. Saini J, Kesavadas C, Thomas B, Kapilamoorthy TR, Gupta AK, Radhakrishnan A, Radhakrishnan K (2009) Susceptibility weighted imaging in the diagnostic evaluation of patients with intractable epilepsy. Epilepsia. ;50(6):1462-73. (if=5.295, ci=31)

5. Kesavadas C, Santhosh K, Thomas B.( 2010) Susceptibility weighted imaging in cerebral hypoperfusion-can we predict increased oxygen extraction fraction? Neuroradiology. 52(11):1047-54 (if=2.093, ci=49)

6. Gupta D, Saini J, Kesavadas C, Sarma PS, Kishore A (2010) Utility of susceptibility-weighted MRI in differentiating Parkinson's disease and atypical parkinsonism. Neuroradiology. Dec;52(12):1087-94. (if=2.093, ci=83)

7. Jolapara M, Kesavadas C, Radhakrishnan VV, Thomas B, Gupta AK, Bodhey N, Patro S, Saini J, George U, Sarma PS. (2010) Role of diffusion tensor imaging in differentiating subtypes of meningiomas. J Neuroradiol. 2010 Dec;37(5):277-83 (if=2.526, ci=26)

8. Kallakatta RN, Radhakrishnan A, Fayaz RK, Unnikrishnan JP, Kesavadas C, Sarma SP(2011) Clinical and functional outcome and factors predicting prognosis in osmotic demyelination syndrome in 25 patients.J Neurol Neurosurg Psychiatry. Mar;82(3):326-31. (if=7.349, ci=70)

9. Saini J, Chatterjee S, Thomas B, Kesavadas C.(2011) Conventional and advanced magnetic resonance imaging in tumefactive demyelination. Acta Radiol. Dec 1;52(10):1159-68. (if=2.011, ci=28)

10. Rathore C, Thomas B, Kesavadas C, Abraham M, Radhakrishnan K. ( 2013) Calcified neurocysticercosis lesions and antiepileptic drug-resistant epilepsy: a surgically remediable syndrome? Epilepsia. Oct;54(10):1815-22. (if=5.295, ci=26)

372

MAHDI, ABBAS ALI (b 1964), Vice Chancellor,Era University,Sarfarazganj Hardoi Road,Lucknow-22003


Prof. Abbas Ali Mahdi has made pioneering contributions in the area of natural products, metal toxicity and Free Radical Biology. He has over three decades of research and teaching experience with 330 publications (having about 6000 citations), including 25 book chapters. He has written five books and has been Editor/Member Editorial Board of many Journals. He has guided dozens of doctoral and masters students and supervised over fifty research projects including the DST – FIST and The World Academy of Science project (Trieste, Italy). His work on protection from free radical mediated cellular injury by herbals in diabetic rats is well recognized. His in depth studies related to perturbation of antioxidant levels consequent to oxidative stress in seminal plasma of infertile men showed remarkable amelioration by some herbal preparations. His studies demonstrated significant improvement in sperm count and motility following inhibition of lipid peroxidation in seminal plasma by M. pruriens in male sterility. He studies further showed that treatment with M. pruriens and W. sominifera significantly ameliorated psychological stress, regulated steroidogenesis and improved semen quality in infertile men. Also, his extensive studies on possible association of aluminium with Alzheimer’s disease have demonstrated that Al may be linked with neurolipofuscinogenesis, mitochondrial and endoplasmic reticulum stress and these changes may be responsible for the development of age related disorders, such as Alzheimer’s disease. He explored metabolomics to study many diseases, including essential hypertension.

Proposer: Dr. Vinay Kumar Khanna, Seconder: Dr. Swaran Jeet Singh Flora


1. Ameta K, Gupta A, Kumar S, Sethi R, Kumar D, Mahdi AA (2017). Essential hypertension: A filtered serum based metabolomics study. Sci Rep.19;7(1):2153 (if=4.259, ci=2)

2. Ameta K, Gupta A, Ameta D, Sethi R, Kumar D, Ahmad I, Mahdi AA (2016). 1H NMR-derived metabolomics of filtered serum of myocardial ischemia in unstable angina patients. Clin Chim Acta.456:56-62 (if=2.873, ci=2)

3. Rizvi, .S.M.H., Parveen, A., Verma, A.K., Ahmad, I, Arshad, M, Mahdi, A.A(2014). Aluminium induced endoplasmic reticulum stress mediated cell death in SH-SY5Y neuroblastoma cell line is independent of p53. PLoS One. 9(5):e98409 (if=2.806, ci=25)

4. Madan, E, Gogna, R, Kuppusamy, P, Bhatt, M, Mahdi, AA, Pati U (2013). SCO2 Induces p53-Mediated Apoptosis by Thr845 Phosphorylation of ASK-1 and Dissociation of the ASK-1–Trx Complex. Molecular and Cellular Biology 33 (7), 1285-1302 (if=4.398, ci=21)

5. Ahmad MK, Mahdi AA, Shukla KK, Islam N, Rajender S, Madhukar D, Shankhwar SN, Ahmad S(2010). Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males. Fertil Ste (if=4.373, ci=119)

6. Shukla KK, Mahdi AA, Ahmad MK, Shankhwar SN, Rajender S, Jaiswar SP (2009). Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis. Fertil Steril. ;92(6):1934-40. (if=4.373, ci=89)

7. Tripathi S, Mahdi AA, Nawab A, Chander R, Hasan M, Siddiqui MS, Mahdi F, Mitra K, Bajpai VK (2009). Influence of age on aluminum induced lipid peroxidation and neurolipofuscin in frontal cortex of rat brain: a behavioral, biochemical and ultrastr (if=2.746, ci=71)

8. Mahdi AA, Shukla KK, Ahmad MK, Rajender S, Shankhwar SN, Singh V, Dalela D(2009). Withania somnifera Improves Semen Quality in Stress-Related Male Fertility. Evid Based Complement Alternat Med. 2009 Sep 29. [Epub ahead of print] (if=1.931, ci=66)

9. Ahmad MK, Mahdi AA, Shukla KK, Islam N, Jaiswar SP, Ahmad S (2008). Effect of Mucuna pruriens on semen profile and biochemical parameters in seminal plasma of infertile men. Fertil Steril. 90(3):627-35. (if=4.373, ci=68)

10. Chandra A, Mahdi AA, Ahmad S, Singh RK (2007). Indian herbs result in hypoglycemic responses in streptozotocin-induced diabetic rats. Nutrition research. 27(3), 161-168 (if=2.737, ci=54)

373

MISHRA, PRADYUMNA KUMAR (b 1973), Deputy Director, ICMR-National Institute for Research in Environmental Health, Bhopal


Dr. Pradyumna Kumar Mishra has successfully developed nano-engineered Dendritic cell based bio-therapeutics for selective targeting of tumor re-initiating cells in cancers of the female reproductive tract and gastro-intestinal malignancies. These unique nano-engineering vaccines which involves encapsulation of autologous tumor lysates also helps in treating the residual disease following administration of standard therapy in Hepatitis B and Hepatis C virus malignant infections. As the therapeutic validations of these formulations conducted in restricted settings using limited patients samples have yielded significant positive outcome, the theraputic approach developed by him appear to be safe, effective and patient-compliant with immense potential for clinical translation. Besides, Dr. Mishra’s laboratory has provided unprecedented molecular understanding into the role of prooxidant-induced carcinogenesis in the population exposed to environmental carcinogens either at acute or chronic levels. These studies from his laboratory are regarded fundamental towards understanding the genomic and epigenomic repercussion of pro-oxidant chemical moieties from an environmental health perspective. Based upon this comprehensive framework of exposure-response relationship, he has designed and validated nano-biosensors that would be able to predict an individual's risk of developing the disease using circulating epigenomic signatures in air-pollution exposed populations. Moreover, Dr. Mishra has developed two quantitative (real-time) PCR based technologies for rapid identification and characterization of occult hepatitis C virus and latent tuberculosis infection which are now being used for screening the prevalence of sexually transmitted hepatitis C virus infection and genital tuberculosis in semi-urban and rural population, fraught with environmental and economical perils.

Proposer: Prof. N.K. Lohiya, Seconder: Dr. Anil Suri


1. Shandilya R, Bhargava A, Bunkar N, Tiwari R, Goryacheva IY, Mishra PK. Nanobiosensors: Point-of-care approaches for cancer diagnostics. Biosens Bioelectron. 2019 Apr 1;130:147-165. (if=8.173)

2. Mishra DK, Shandilya R, Mishra PK. Lipid based nanocarriers: a translational perspective. Nanomedicine. 2018 Jun 23;14(7):2023-2050. (if=6.306, ci=8)

3. Goryacheva OA, Novikova AS, Drozd DD, Pidenko PS, Ponomaryeva TS, Bakal AA, Mishra PK, Beloglazova NV, Goryacheva IY. Water-dispersed luminescent quantum dots for miRNA detection. TrAC Trends in Analytical Chemistry. 2019 February; 111: 97-205.(if=7.034)

4. Bhargava A, Tamrakar S, Aglawe A, Lad H, Srivastava RK, Mishra DK, Tiwari R, Chaudhury K, Goryacheva IY, Mishra PK. Ultrafine particulate matter impairs mitochondrial redox homeostasis and activates phosphatidylinositol 3-kinase mediated DNA damage responses in lymphocytes. Environ Pollut. 2018 Mar;234:406-419. (if=5.291, ci=6)

5. Bhargava A, Bunkar N, Khare NK, Mishra D, Mishra PK. Nanoengineered strategies to optimize dendritic cells for gastrointestinal tumor immunotherapy: from biology to translational medicine. Nanomedicine (Lond). 2014 Jul;9(14):2187-202. (if=5.005, ci=7)

6. Bhargava A, Mishra D, Khan S, Varshney SK, Banerjee S, Mishra PK. Assessment of tumor antigen-loaded solid lipid nanoparticles as an efficient delivery system for dendritic cell engineering. Nanomedicine (Lond). 2013 Jul;8(7):1067-84. (if=5.005, ci=19)

7. Bhargava A, Raghuram GV, Pathak N, Varshney S, Jatawa SK, Jain D, Mishra PK. Occult hepatitis C virus elicits mitochondrial oxidative stress in lymphocytes and triggers PI3-kinase-mediated DNA damage response. Free Radic Biol Med. 2011 Nov 1;51(9):1806-14. (if=6.020, ci=40)

8. Mishra D, Mishra PK, Dabadghao S, Dubey V, Nahar M, Jain NK. Comparative evaluation of hepatitis B surface antigen-loaded elastic liposomes and ethosomes for human dendritic cell uptake and immune response. Nanomedicine. 2010 Feb;6(1):110-8. (if=6.306, ci=49)

9. Mishra PK, Mishra D, Dubey V, Nahar M, Dabadghao S, Jain NK. Systemic and mucosal immune response induced by transcutaneous immunization using Hepatitis B surface antigen-loaded modified liposomes. Eur J Pharm Sci. 2008 Apr 23;33(4-5):424-33. (if=3.869, ci=84)

10. Pathak N, Mishra PK, Manivannan B, Lohiya NK. Sterility due to inhibition of sperm motility by oral administration of benzene chromatographic fraction of the chloroform extract of the seeds of Carica papaya in rats. Phytomedicine. 2000 Jul;7(4):325-33. (if=3.610, ci=70)

374

MOHANAN, PARAYANTHALA VALAPPIL (b 1962), Scientist-G, Sree Chitra Tirunal Institute for Medical Sciences and Technology (Govt. of India), Trivandrum


Mohanan obtained BSc, MSc from Calicut University and PhD from Kerala University. He was a JSPS Post doctoral Fellow at the University of Tsukuba, Japan in the field of Neurotoxicity. He joined Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST) in 1989 and has spent 30 years of professional life here. As a toxicologist he has been intimately associated with all the medical devices/ technologies developed at SCTIMST. Currently he heads the Division of Toxicology. He is a Visiting Professor and Visiting Researcher at Toyo University, Japan and a Certified Biological Safety Specialist. He received lifetime achievement award from the Society of Toxicology India, for the outstanding contribution in the field of toxicology. Mohanan has been teaching toxicology to PhD, MPhil, MTech, Postgraduate diploma/certificate courses. He has completed 8 externally funded (4 DST, 2 DBT, 2 ICMR) research projects as Principal Investigator, including a new mega project on the ‘Development of Human-on-a-chip’. Patented an ELISA kit for the measurement of pyrogenicity. He has made significant contributions for the development of medical device industry and medical device regulations in India, and India getting GLP membership in OECD countries. He received certificate of appreciation from the Hon. Minister of Science and Technology, Govt. of India for the contribution to India getting full adherent status on GLP from OECD. Mohanan is a Fellow of Society of Toxicology, Fellow of Society of Applied Biotechnology and Fellow of Academy of Sciences for animal welfare. He has authored 184 publications and edited 3 books.

Proposer: Dr. Madhu Dikshit, Seconder: Dr. Manoj Prasad


1. Syama S, Willi Paul, Sabareeswaran A, Mohanan PV* (2017) Raman spectroscopy for the detection of organ distribution and clearance of PEGylated reduced graphene oxide and biological consequences. Biomaterials,131,121-130. (if=8.806, ci=13)

2. Syama S, Aby C P, Toru Maekawa, Sakthikumar D, Mohanan PV* (2017) Nano-bio compatibility of PEGylated reduced graphene oxide on mesenchymal stem cells. 2D Materials, 4 (2). doi.org/10.1088/2053-1583/aa65c2. (if=6.9, ci=6)

3. Remya NS, Syama S, Sabareeswaran A, Mohanan PV* (2017). Investigation of chronic toxicity of hydroxyapatite nanoparticles administered orally for one year in wistar rats. Materials Science and Engineering C, 76, 518-527 (if=5.08, ci=7)

4. Remya NS, Syama S, Sabareeswaran A, Mohanan PV*(2016). Toxicity, toxicokinetics and biodistribution of dextran stabilized Iron oxide Nanoparticles for biomedical applications. Int J Pharm. 511(1):586-98. doi:10.1016/j.ijpharm.2016.06.119 (if=3.862, ci=25)

5. Remya NS, Syama S, Gayathri V, Varma HK, Mohanan PV (2014) An in vitro study on the interaction of hydroxyapatite nanoparticles and bone marrow mesenchymal stem cells for assessing the toxicological behaviour. Colloids and Surfaces B: Biointerfaces (if=3.997, ci=47)

6. Sruthi S, Mohanan PV* (2015). Investigation on cellular interactions of astrocytes with Zinc oxide nanoparticles using rat C6 cell line. Colloids and Surfaces B: Biointerfaces 133, 1–11 (if=3.997, ci=22)

7. Remya NS, Syama S, Gayathri V, Varma HK, Mohanan PV* (2014). An in vitro study on the interaction of hydroxyapatite nanoparticles and bone marrow mesenchymal stem cells for assessing the toxicological behavior. Colloids Surf B Biointerfaces, 28(117C) (if=3.997, ci=47)

8. Easo SL, Mohanan PV* (2013). Dextran stabilized iron oxide nanoparticles synthesis, characterization and in vitro studies. Carbohydrate Polymers. 92(1), 726-732. (if=5.158, ci=71)

9. Yamamoto H, Mohanan PV (2002) Preventive effect of melatonin against brain mitochondria DNA damage, lipid peroxidation and seizures induced by kainic acid. Toxicology letters 129 (1-2), 99-105 (if=3.858, ci=73)

10. Yamamoto H, Mohanan PV (2001) Effects of melatonin on paraquat or ultraviolet light exposure‐induced DNA damage. Journal of pineal research 31 (4), 308-313 (if=11.6, ci=27)

375

NEGI, VIR SINGH (b 1963), Professor, JIPMER, Puducherry


I am pleased to nominate Dr. V.S. Negi for the fellowship of the NASI, Allahabad. Dr. Negi is presently working as Professor and Head, Department of Clinical Immunology at JIPMER, Puducherry, He has contributed significantly to improvement in patient care, teaching, training and research in the field of autoimmune rheumatic disorders in India. Dr. Negi established the ‘Clinical Immunology Diagnostic and Research Laboratory’ through the FIST programme of the DST in 2002 and the Department of Clinical Immunology at JIPMER, Puducherry in 2009. The department provides state of the art treatment facilities in this field of autoimmune rheumatic disorders and primary immunodeficiency diseases. He is exploring the use of stem cell transplant in autoimmune diseases. Dr. Negi is one of the few clinician scientists in the field of Medicine. His are of interest are Immunogenetics and immunopathology of autoimmune rheumatic disorders. He has a good publication record and has had collaboration with French group. He is running a joint (cotutelle) international PhD program in Clinical Immunology since 2011 with the University of Paris-7, France. He is a regular Visiting Professor to many hospitals in Paris and University of Paris, France. For his contributions in the field of Medicine and Rheumatic diseases, Dr. Negi has been conferred fellowships of the Royal College of Physicians (FRCP), London, American College of Rheumatology (FACR), National Academy of Medical Sciences (FAMS) and Indian college of Physicians (FICP). He has also been honoured by the Indian Rheumatology Association (IRA) with IRA oration for the year 2016.

Proposer: Prof. Amita Aggarwal, Seconder: Dr. Kanjaksha Ghosh


1. Muralidharan, Niveditha; Mariaselvam, Christina M; Jain, Vikramraj K; Gulati, Reena; Negi, Vir S; 2016, ATIC 347C> G gene polymorphism may be associated with methotrexate-induced adverse events in south Indian Tamil rheumatoid arthritis. Pharmacogeno (if=2.35, ci=5)

2. Misra DP, Sharma A, Kadhiravan T, Negi VS., 2016, A scoping review of the use of non-biologic disease modifying anti-rheumatic drugs in the management of large vessel vasculitis. Autoimmun Rev. doi: http://dx.doi.org/10.1016/j.autrev.12.009 (if=8.49, ci=5)

3. Muralidharan, Niveditha; Antony, Paul T; Jain, Vikramraj K; Mariaselvam, Christina Mary; Negi, Vir Singh; 2015, Multidrug resistance 1 (MDR1) 3435C> T gene polymorphism influences the clinical phenotype and methotrexate-induced adverse events in Sout (if=2.96, ci=6)

4. Devaraju P, Gulati R, Antony PT, Mithun CB, Negi VS. 2015, Susceptibility to SLE in South Indian Tamils may be influenced by genetic selection pressure on TLR2 and TLR9 genes. Mol Immunol.; 64(1):123-6. (if=3.38, ci=10)

5. Devaraju, Panneer; Reni, Benita Nancy; Gulati, Reena; Mehra, Sonal; Negi, Vir S; 2014, Complement C1q and C2 polymorphisms are not risk factors for SLE in Indian Tamils, Immunobiology, 219 (6), 465-468 (if=2.72, ci=6)

6. Panneer, D; Antony, PT; Negi, VS; 2013, Q222R polymorphism in DNAse I gene is a risk factor for nephritis in South Indian SLE patients. Lupus, 22(10), 996-1000 (if=2.6, ci=8)

7. Bayry J, Negi VS, Kaveri SV. Intravenous immunoglobulin therapy in rheumatic diseases. Nat Rev Rheumatol 2011;7:349-359. (if=10.53, ci=100)

8. Vani J, Elluru S, Negi VS, Lacroix-Desmazes S, Kazatchkine MD, Bayry J, Kaveri SV. Role of natural antibodies in immune homeostasis: IVIg perspective. Autoimmun Rev 2008 Jun;7(6):440-4. (if=8.49, ci=71)

9. Negi VS, Elluru S, Sibéril S, Graff-Dubois S, Mouthon L, Kazatchkine MD, Lacroix-Desmazes S, Bayry J, Kaveri SV. Intravenous immunoglobulin: an update on the clinical use and mechanisms of action. J Clin Immunol. 2007 May;27(3):233-45 (if=3.09, ci=211)

10. Negi VS, Tripathy NK, Misra R, Nityanand S. Antiendothelial cell antibodies in scleroderma correlate with severe digital ischemia and pulmonary arterial hypertension. J Rheumatol. 1998 Mar;25(3):462-6. (if=3.24, ci=133)

376

NEINIWAL, SANJEEV KUMAR (b 1972), Professor of Ophthalmology, JLN Medical College & Hospital, Ajmer (Rajasthan)


Dr. Sanjeev Kumar Neiniwal is having good clinical acumen and sincerity towards his work, He is proficient in all ophthalmic diagnostic and therapeutic modalities like FFA, OCT, Ocular USG, doing retinal & YAG Lasers as well as doing advanced vitreoretinal surgeries along with routine cataract and other eye surgeries. Dr. Neiniwal has also shown keen interest in research activities and till now he is having around 125 scientific publications of them 34 are in indexed journals.Dr. Neiniwal had worked as Editor of "DOS Times" ; a scientific ophthalmic magazinefrom 2001-03 published by Delhi Ophthalmological Society (DOS). Dr. Neiniwal has also been awarded as "Distinguished Resource Teacher" 3 times as well as "Dr. R N Sabharwal Medal" 4 times for his academic excellence by DOS. Recently he has got Fellowship of International Medical Sciences Academy (FIMSA) also. It is sure that Dr. Neiniwal will continue to be a sincere, hard working and committed Ophthalmologist and he will be an asset to any organisation he join. So, it is strongly feel that he deserves to be awarded Fellowship by NASI.

Proposer: Prof. Shally Awasthi, Seconder: Prof. Sanjay Kumar Agarwal


1. Nainiwal SK et al. Eye changes in pregnancy: Many things Can be Missed. IOSR JDMS 2017; Vol 16, Issue 7 Version IX: Pages 1-8. (if= 5.244, IC Value 83.27, ci=Index Copernicus)

2. Nainiwal SK et al. Study of pattern, demographic profile and visual outcome in open globe injuries at tertiary eye care hospital in central Rajasthan, India. IOSR JDMS 2016; Vol 15 (6), Version XV: Pages 51-57. (if= 5.244, IC Value 83.27, ci=Index Copernicus)

3. Nainiwal SK et al. Analysis of visually handicap patients attending out patient department of a tertiary eye care hospital for visual handicap certification in central Rajasthan, India. IOSR JDMS 2016; Vol 15 (5), Version II: Pages 36-39. (if= 5.244, IC Value 83.27, ci=Index Copernicus)

4. Verma L, Tewari HK, Nainiwal S, Ravindranathan J. Transpupillary thermotherapy for subfoveal choroidal neovascular membrane secondary to age-related macular degeneration. Indian J Ophthalmolgy March 2004; Vol 52(1): 35-40 (if=RG Journal Impact 0.38, ci=Pubmed)

5. Nainiwal S, Chand M, Verma L, Garg SP, Tewari HK, Kashyap S.Intraocular live cysticircus larvae. Ophthalmic Surgery, Lasers & Imaging 2003 Nov-Dec; 34(6): 464-66 (if=RG Journal Impact 0.41, ci=Pubmed)

6. Nainiwal S, Kumar H, Kumar A. Laser conjunctivoplasty: A new technique for correction of mild medial ectropion of lower lid. Orbit 2003 Sept; 22(3): 199-201. (if=RG Journal Impact 0.14, ci=Pubmed)

7. Kumar A, Nainiwal S, Sriniwas B. Intravitreal low molecular weight heparin in PVR surgery. Indian J Ophthalmology 2003 Mar; 51(1): 67-70. (if=RG Journal Impact 0.19, ci=Pubmed)

8. Kumar H, Nainiwal S, Singh U, Azad RV, Paul VK. Examination stress induced by screening for retinopathy of prematurity. J Paediatr Ophthalmol & Strabismus 2002 Nov-Dec; 39(6): 349-50. (if=RG Journal Impact 0.44, ci=Pubmed)

9. Kumar A, Nainiwal S, Chaudhary I, Tewari HK, Verma L. Role of daunorubicin in inhibiting proliferative vitreoretinopathy after retinal detachment surgery. Clinical and Experimental Ophthalmology 2002 Oct; 30(5): 348-51. (if=RG Journal Impact 0.91, ci=Pubmed)

10. Nainiwal SK, Titiyal JS, Sen S. Intratarsal cysticercosis of the lower lid. Orbit 2002; 21(3): 223-5. (if=RG Journal Impact 0.14, ci=Pubmed)

377

PARVEZ, SUHEL (b 1978), Professor and Head, Department of Toxicology, Jamia Hamdard, New Delhi


Few areas of neuroscience have mobilized as many resources as hunt for cellular substrate of memory. A fundamental question in neurobiology concerns the mechanisms by which synaptic activation triggers transcriptional changes in the nucleus. Prof. Parvez has contributed in elucidating these mechanisms and provided novel insight into the biological basis of information storage in the nervous system (Parvez et al., 2010a). This venture has been rewarded with spectacular breakthroughs, in particular the region specific modulation of long-term potentiation and long-term depression, which are the best-studied models of functional plasticity. Prof. Parvez has also investigated the molecular components and physiological importance of calcium signaling and Calcium-Release-Activated-Calcium channels (CRAC) in signal transduction pathway (Parvez et al., 2008). The goal is to identify the messengers in the signaling cascade at the molecular level and develop pharmacological tools to modulate this ubiquitous signaling mechanism in a therapeutically meaningful manner. The pathophysiological mechanism leading to neurological conditions like Parkinson's disease (PD) and ischemic stroke is still not understood. Apoptotic cell death in the substantia nigra seems to be a crucial factor. The underlying mechanisms may include a defective mitochondrial respiratory chain and/or opening of the permeability transition pore (mtPTP) in the inner mitochondrial membrane. Prof. Parvez’s lab has established the critical role of mtPTP and neuroprotection by using dopamine-D2-agonists and melatonin (Ashafaq et al., 2017, Chaudhary et al., 2017, Waseem et al., 2016a, Waseem et al., 2017). The critical interaction between ion channels was also successfully investigated (Parvez et al., 2010b, Waseem et al., 2016b).

Proposer: Prof. Seyed E. Hasnain, Seconder: Prof. J.K. Batra


1. Ashafaq M, Tabassum H & Parvez S. (2017). Modulation of behavioral deficits and neurodegeneration by tannic acid in experimental stroke challenged Wistar rats. Molecular Neurobiology, 54(8):5941-5951 (I.F. 6.129) [Corresponding Author] (if=6.129)

2. Waseem M, Sahu S, Salman M, Choudhury A, Kar S, Tabassum H & Parvez S. (2017). Melatonin pre-treatment mitigates SHSY-5Y cells against oxaliplatin induced mitochondrial stress and apoptotic cell death. PLoS One, 12(7):e0180953 [C. Author) (if=2.806)

3. Chaudhary S, Sahu U, Kar S & Parvez S. (2017). Phytanic acid induced neurotoxicological manifestations and apoptosis ameliorated by mitochondria mediated action of melatonin. Molecular Neurobiology, 54:6960-6969 (if=6.129)

4. Waseem M, Tabassum H & Parvez S. (2016a). Neuroprotective effects of melatonin as evidenced by abrogation of oxaliplatin induced behavioral alterations, mitochondrial dysfunction and neurotoxicity in rat brain. Mitochondrion, 30:168-176. (if=3.704, ci=07)

5. Waseem M, Tabassum H & Parvez S. (2016b). Melatonin modulates permeability transition pore and 5-hydroxydecanoate induced KATP channel inhibition in isolated brain mitochondria. Mitochondrion, 31:1-8. (if=3.704, ci=03)

6. Parvez S, Ramachandran B & Frey JU. (2010). Functional differences between & across different regions of the apical branch of hippocampal CA1 dendrites with respect to LTD induction and synaptic cross-tagging. J. Neurosc. 30(14):5118-23. (if=5.924, ci=18)

7. Parvez S, Winkler-Stuck K, Hertel S, Schönfeld P & Siemen D. (2010). The dopamine-D2-receptor agonist ropinirole dose-dependently blocks the Ca2+-triggered permeability transition of mitochondria. BBA (Bioenergetics) 1797(6-7):1245-50. (if=4.864, ci=23)

8. Parvez S, Beck A, Peinelt C, Soboloff J, Lis A, Monteilh-Zoller M, Gill DL, Fleig A & Penner R. (2008). STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation. FASEB J 22(3):752-61. (if=5.299, ci=100)

9. Sayeed I*, Parvez S*, Winkler-Stuck K, Sietz G, Trieu I, Wallesch CW, Schönfeld P & Siemen D. (2006). Patch clamp reveals powerful blockade of the mitochondrial PTP by the dopamine-D2-receptor agonist pramipexole. FASEB J 20(3):556-558. (if=5.299, ci=43)

10. Parvez S & Raisuddin S. (2005). Protein carbonyls: novel biomarkers of exposure to oxidative stress-inducing pesticides in freshwater fish Channa punctata (Bloch). Environmental Toxicology & Pharmacology 20(1):112-117. (if=2.187, ci=131)

378

PRASAD, KASHI NATH (b 1954), Professor and Head, Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow- 226014


Dr. Prasad developed PCR and lymphocyte transformation test (LTT) for diagnosis of Campylobacter jejuni infection in patients with Guillain-Barré syndrome (GBS) and LTT/MTT for neurocysticercosis. He reported first-time that Th1 cytokines-mediated neuronal inflammation led to disease progression in early phase of GBS, whereas Th2 cytokines-response during late phase helped in recovery [Arch Neurol 2011; 68:445-52; (selected for editorial)]. Subsequently he demonstrated these observations in chicken model (Med Microbiol Immunol 2012; 201:177-87). He reported first-time association of host factors- TLR4, ICAM1, MMP9 and GST polymorphisms and their altered expressions with seizure in neurocysticercosis [J Infect Dis 2010; 202:1219-25 (selected for editorial); Neurology 2012; 78:618-625; J Neuroimmunol 2014; 276:166-71; Mol Neurobiol 2017; 54:2843-51]. These studies explained first-time why some persons with neurocysticercosis developed seizures, while others remained symptom-free. Dr. Prasad demonstrated PPARγ polymorphism, infection with Helicobacter pylori CagL D58K59 polymorphic genotype and functionally intact cagPAI as risks for gastric cancer development (Annals Oncol 2008; 19:1299-1303; Gastric Cancer 2013; 16:435-9; Path Dis 2018;76). Dr Prasad studied New Delhi metallo-beta-lactamases, 16S-rRNA methyltransferases, and mcr-1-mediated colistin-resistance in Gram-negative bacteria (J Antimicrob Chemother 2013; 68:1543-50; Int J Antimicrob Agents 2014; 44:30-37; Antimicrob Agents Chemother 2018; 62:e01885-17). He reported first-time 16S-rRNA methyltransferases, rmtC and rmtF with blaNDM-1 were mobilized on chromosome in Pseudomonas aeruginosa (Emerg Infect Dis 2015; 21:2059-62). He demonstrated first-time antibacterial and antibiofilm properties of cuprous oxide nanoparticles against Staphylococcus aureus (Antimicrob Agents Chemother 2015; 59:6882-90). He was conferred SR Naik, SC Agarwal, UC Chaturvedi, PN Chhuttani, BK Aikat Orations/Awards by various Academic Societies/Bodies/ICMR.

Proposer: Prof. Umesh Chandra Chaturvedi, Seconder: Prof. Rakesh Kapoor


1. Prasad KN*, Prasad N, Gupta Amit, Sharma RK, Verma AK, Ayyagari A 2004. Fungal peritonitis in patients on continuous ambulatory peritoneal dialysis: a single centre Indian experience. J Infection 48: 96-101 (if=4.603, ci=129)

2. Prasad KN*, Mishra AM, Gupta Deepti, Husain Nuzhat, Husain Mazhar and Gupta RK 2006. Analysis of microbial etiology and mortality in patients with brain abscess. J Infection 53:221-7 (if=4.603, ci=136)

3. Sinha S, Prasad KN*, Jain D, Pandey CM, Jha S, Pradhan S 2007. Preceding infections and anti-ganglioside antibodies in patients with Guillain-Barré syndrome: a single center prospective case-control study. Clin Microbiol Infect 13: 334-7 (if=5.394, ci=51)

4. Prasad KN*, Saxena A, Ghoshal UC, Bhagat MR, Krishnanai N 2008. Analysis of Pro12Ala PPAR gamma polymorphism and Helicobacter pylori infection in gastric adenocarcinoma and peptic ulcer disease. Annals Oncol 19: 1299-1303 (if=13.926, ci=43)

5. Verma A, Prasad KN*, Gupta RK, Singh AK, Nyati KK, Rizwan A, Pandey CM, Paliwal VK 2010. TLR-4 polymorphism and its association with symptomatic neurocysticercosis. J Infect Dis 202: 1219-25 (if=5.186, ci=58)

6. Nyati KK, Prasad KN*, Rizwan A, Verma A, Paliwal VK 2011. Th1 and Th2 response to Campylobacter jejuni antigen in Guillain-Barré syndrome. Arch Neurol 68: 445-52 (if=11.460, ci=47)

7. Rahman M, Shukla S, Prasad KN*, Ovejero CM, Pati BK, Tripathi A, Srivastava AK, Gonzalez-Zorn B 2014. Prevalence and molecular characterization of New Delhi metallo-β-lactamases NDM-1, NDM-5, NDM-6 and NDM-7 in multidrug resistant Enterobacteriaceae from India. Int J Antimicrob Agents 44:30-37 (if=4.253, ci=77)

8. Rahman M, Prasad KN*, Pathak A, Pati BK, Singh A, Ovejero CM, Ahmed S, Gonzalez-Zorn B 2015. RmtC and RmtF 16S rRNA methyltransferases in NDM-1 producing Pseudomonas aeruginosa. Emerg Infect Dis 21:2059-62 (if=7.42, ci=20)

9. Singh A, Ahmed A, Prasad KN*, Khanduja S, Singh SK, Srivastava JK, Gajbhiye NS 2015. Antibiofilm and membrane damaging potential of cuprous oxide nanoparticles against Staphylococcus aureus with reduced susceptibility to vancomycin. Antimicrob Agents Chemother 59: 6882-90 (if=4.476, ci=14)

10. Singh A, Prasad KN*, Singh AK, Singh SK, Gupta KK, Paliwal VK, Pandey CM, Gupta RK 2017. Human glutathione S-transferase enzyme gene polymorphisms and their association with neurocysticercosis. Mol Neurobiol 54:2843-51 (if=5.076, ci=08)

379

RAJKUMAR, HEMALATHA (b 1962), Director, ICMR-National Institute of Nutrition, Hyderabad


Dr. Hemalatha, MBBS, MD; took over as the 13th Director of the ICMR-National Institute of Nutrition in December 2017. She heads the largest Nutrition research organisation in the country that covers the spectrum from basic to public health. Dr.Hemalatha has carried out extensive research in the realm of Nutrition, Infection and Immunity with special emphasis on women and child health, preconception nutrition and the first 1000 days of life. She also conducted a battery of studies on probiotics and gut as well as vaginal microbiome profiling in pregnant womenthat have generated vital information on the impact of inflammation on foetal growth and pregnancy outcomes. Her emphasis has been on strengthening inter-sectoral, inter-institutional, inter-disciplinary synergy for finding practical solutions to the nutrition issues confronting the country. Dr.Hemalatha is an expert member of various task force committees of the Ministry of Women and Child Development, Ministry of Health and Family Welfare, Government of India; Food Safety and Standards of India (FSSAI), National Technical Board on Nutrition and National Council of Nutrition of NITI Aayog. Dr. Hemalatha is recipient of Ponduri VR Rao Gold Medal, Dr. Rajammal P Devadas Memorial Award. She is a Fellow of the National Academy of Medical Sciences (FNAMS), International Union of Nutrition Sciences (FIUNS) and Telangana Academy of Sciences (FTAS). She has served as Joint Secretary of the Nutrition Society of India. With her extensive contributions and recognition in the field of nutrition sciences we recommend her nomination for election as a Fellow of NASI in Medical Science.

Proposer: Dr. Mahtab S. Bamji , Seconder: Dr. Kamala Krishnaswamy


1. R.Hemalatha, Ramalakshmi BA, Krishna Swetha G, Uday Kumar P, Madhusudhan Rao D, Balakrishna N, Annapurna V (2011): Cervicovaginal inflammatory cytokines and sphingomyelinase in women with and without bacterial vaginosis. (if=2.399, ci=21)

2. Hemalatha R, Paola Mastromarino, Baru Anantha Ramalaxmi, N.V.Balakrishna and B Sesikeran (2012). Effectiveness of vaginal tablets containing Lactobacilli versus pH tablets on vaginal health and inflammatory cytokines; a randomized, double-blind study.(if=2.544, ci=34)

3. K.V.Radhakrishna, Hemalatha R (corresponding author), J.J.Babu Geddam, P.Ajey Kumar, N.Balakrishna, Veena Shatrugna (2013). Effectiveness of zinc supplementation to full term normal infants: A community based double blind, randomized, controlled, clinical trial. PLoS ONE 8(5): e61486. doi:10.1371/ journal.pone.0061486. (if=2.766, ci=9)

4. Hemalatha Rajkumar, Arthur C. Ouwehand, Sofia D. Forssten, J. J. Babu, Raja Sriswan Mamidi, Bhaskar V, Kankipati Vijaya Radhakrishna (2014): Community-based randomized double blind controlled trial of Lactobacillus paracasei and Bifidobacterium lactis on reducing risk for diarrhea and fever in preschool children in an urban slum in India. Europe (if=2.8, ci=9)

5. Hemalatha Rajkumar, Manoj kumar, Nilita Das, Nishanth Kumar, Hanumanth R. Challa, Ravinder Nagpal (2014). Effect of probiotic Lactobacillus salivarius UBL S22 and prebiotic fructo-oligosaccharide on serum lipids, inflammatory markers, insulin sensitivity and gut bacteria in healthy young volunteers: A randomized controlled single-blind pilot stu (if=3.07, ci=44)

6. Vijayendra Chary, R.Hemalatha (corresponding author), M.Seshacharyulu, M.Vasudeva Murali, D.Jayaprakash, B.Dinesh Kumar (2015): Vitamin D deficiency in pregnant women impairs regulatory T cell function. The Journal of Steroid Biochemistry and Molecular Biology, Volume 147, Pp 48–55. (if=3.87, ci=45)

7. Himaja Nallagatla, Rajkumar Hemalatha (corresponding author), Narendra Babu Kondapalli and Shujauddin Mohammed (2016): Impact of a novel symbiotic supplementation during gestation and lactation on immune responses in the Swiss albino mice offspring. J. Sci. Food Agric, DOI: 10.1002/jsfa.8059 (if=2.279, ci=2)

8. Hemalatha Rajkumar, Ramesh Kumar Ramagoni, Vijayendra Chary Anchoju, Raju Naik Vankudavath, Arshi Uz Zaman Syed (2015). De Novo Transcriptome analysis of Allium cepa L. (Onion) bulb to identify allergens and their epitopes. PLOS ONE;DOI : 10.1371/journal.pone.0135387. (if=3.234, ci=11)

9. Raja Sriswan Mamidi, Hemalatha Rajkumar (corresponding author), K.V.Radhakrishna and J.J.Babu (2016). Secular Trends in Heights and Weights in Boys and Girls over 3 Decades in Rural India, Food and Nutrition Bulletin, 1-14. DOI 10.1177/03/ .379572116647579 (if=1.881, ci=8)

10. A.Vijayendra Chary, R.Hemalatha (corresponding author), M.Vasudeva Murali, D.Jayaprakash and B Dinesh Kumar (2016): Association of T-regulatory cells and CD23/CD21 expression with vitamin D in children with asthma. Annals of allergy asthma and immunology (if=2.599, ci=11)

380

SAXENA, SUNITA (b 1952), Ex Director, National Institute of Pathology, Indian Council of Medical Research, New Delhi


I have known Dr. Sunita Saxena as Director of the National Institute of Pathology and a professional colleague for more than 10 years and have been very impressed with her honesty, sincerity of purpose and devotion to duty. A pathologist by training, she is one of the few molecular pathologists in country using trans disciplinary approaches in understanding the molecular pathogenesis of important cancers in India. Her current research interests include understanding the molecular basis of Breast cancer and Tobacco associated cancers in North east region using genome-wide approaches. She demonstrated convincingly the occurrence of breast cancer in younger women in India and has established two breast cancer cell lines from primary tumors of young breast cancer patients to act as a tool to delineate the molecular carcinogenesis. Her research work has provided important leads for the identification of genetic risk factors, prognostic biomarkers and novel therapeutic approaches for breast cancer and esophageal cancer in Northeast India. She has received Novartis oration and P.N.Wahi Awards of ICMR and Achanta Lakshmipati Oration from National Academy of Medical Sciences for her work on Breast cancer and Tobacco associated cancers in NE India. Dr. Sunita Saxena has outstanding leadership qualities and also has demonstrated excellent administrative skills and taken institute to different heights of success. Her election to the Academy would send a strong message to encourage research by pathologists who are loaded with diagnostic services.

Proposer: Dr. N.K. Mehra, Seconder: Dr. Nasreen Z. Ehtesham


1. Saxena S, Mital. A, Andal A,: Pattern of interleukins in MCNS of childhood. Nephron 65(1) 56-61, 1993 (if= 2.138, ci= 43)

2. Sunita Saxena; Bharat Rekhi; Anju Bansal; Ashok Bagga; Chintamani C and N.S.Murthy: Clinico-morphological patterns of Breast Cancers Including family history in a Delhi hospital, India- A Cross-sectional study. World Journal of Surgical Oncology (if=1.6, ci=98)

3. Sunita Saxena, Anurupa Chakraborty, Mishi Kaushal Sanjeev Kotwal, Dinesh Bhatnagar, RS Mohil, Chintamani Chintamani, AK Aggarwal, Veena Sharma, PC Sharma, Gilbert Lenior and David Goldgar, Csilla Szabo Contribution of germline BRCA1 and BRCA2 seq (if= 2.198, ci=67)

4. A. Agarwal, S. Verma, U. Burra, NS Murthy, NK Mohanty and S. Saxena “Flow Cytometric analysis of Th1 and Th2 cytokines in PBMCs as a parameter of immunological dysfunction in patients of Superficial Transitional cell carcinoma of bladder”. C (if= 4.711, ci= 74)

5. Chattopadhyay I, Kapur S, Purkayastha J, Phukan R, Kataki A, Mahanta J, Saxena S. Gene expression profile of esophageal cancer in North East India by cDNA microarray analysis. World Jr of Gastroentrology 2007; 13(9):1438-1444. (if= 3.365, ci=25)

6. Chattopadhyay I, Phukan R, Vasudevan M, Singh A, Purkayastha J, Hewitt S, Kataki A, Mahanta J, Kapur S, Saxena S; “Molecular profiling to identify molecular mechanism in esophageal cancer with familial clustering” Oncology Reports 21:1135-1146,2 (if= 2.662, ci=32)

7. Chattopadhyay I, Singh A, Phukan R, Purkayastha J, Kataki A, Mahanta J, Saxena S, Kapur S. Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in (if=2.113, ci=60)

8. Ihsan R, Chauhan PS, Mishra AK, Yadav DS, Kaushal M, Sharma JD, Zomawia E, Verma Y, Kapur S, Saxena S. Multiple Analytic Approaches reveal distinct Gene- Environment interactions in Smokers in Lung Cancers. PLoS One, 6(12): e29431, 2011. (if= 2.806, ci=53)

9. Kaushal M, Mishra AK, Sharma J, Zomawia E, Kataki A, Kapur S, Saxena S. Genomic alterations in breast cancer patients in betel quid and non betel quid chewers. PLoS One 7(8):e43789, 2012. (if= 2.806, ci=15)

10. Singh V, Singh LC, Singh AP, Sharma J, Borthakur BB, Debnath A, Rai AK, Phukan K, Mahanta J, Kataki AC, Kapur S, Saxena S. “Status of epigenetic chromatin modification enzymes and esophageal squamous cell carcinoma risk in northeast Indian popula (if= 3.264, ci=7)

381

SINHA, SUKESH NARAYAN (b 1965) Scientist F/Senior Dy Director, National Institute of Nutrition, Jamai-Osmania, Hyderabad


Dr. Sinha contributed to the field of medical toxicology and particularly towards development of new bio-analytical tools for measuring of toxicants in ambient as well as biological matrices. His innovative contributions have been in varied fields with wide scientific, medical and policy implications. He contributed to development of a new tissue schizontocidal and garnetcytocidal drug (6-methoxy-5,8 di-(4'-amini-1' methylbutylamino quinoline) which is more active and less toxic than primaquine for treatment of Malaria1. He developed a novel method and established health risk assessment for fixing Maximum Residue Limit (MRL) of pesticides in carbonated beverages (1ppb)2. This was adopted by the Joint Parliament Committee, Government of India to monitor pesticide residues in ingredients like sugar, thereby ensuring better standards and promoting exports contributing to the country's economy. He also developed a new biomarker (1-napthol) for estimation of acetylcholinesterase enzyme and toxicants for measuring exposure to pesticides and its effect which are crucial for the prognosis in real time to save lives of exposed victims. He reported Adefovir dipivoxil3 is a potent anti-viral drug for treatment of infested dengue viruses. He proposed the draft of maximum levels for total aflatoxins in dried figs including sampling plans for fixing MRLs at international level. He received prestigious Shnkuntala Arnirchand Award (lCMR) and international fellowships from ICMR & DHR, India and WHO. He has a patent to his credit. He worked in Bio-analytical Toxicology Department, CDC Atlanta and was a visiting scientist at college of Medicine, Cincinnati University, USA. He honed his skills in toxicology at OPCW Netherlands.

Proposer : Dr. G.B. Reddy, Seconder : Dr. V.D. Reddy Ten Best Publications : 1. Sukesh Narayan Sinha, Venkat ReddyBanda, Correlation of pesticide exposure from dietary intake and bio-monitoring: The different sex and socio-economic study of children, Ecotoxicology and Environmental Safety, Volume 162, 30 October 2018, Pages 170-177 (if=4) 2. Sinha, S.N., Kulkarni, P. K., Shah, S.H., Desai, N.M. Patel, G.M., Mansuri, M. M. and Saiyed, H.N., 2005, Gas chromatographic-mass spectroscopic determination of benzene in indoor air during the use of biomass fuels in cooking time, J. Chromatography A. 1065/2, 315-319 (if=4.439, ci=49) 3. Sinha, S.N., Pal, R., Dewan, A., Mansuri, M. M., Saiyed, H.N., 2006, Effect of dissociation energy on ion formation and sensitivity of an analytical method for determination of chlorpyrifos in human blood, using gas chromatography- mass spectrometer (GC-MS in MS/MS). International Journal of Mass Spectrometry (253) 48-57. (if=2.227, ci=36) 4. Sinha, S.N., Kulkarni, P. K., Shah, S.H., Desai, N.M. Patel, G.M., Mansuri, M. M. and Saiyed, H.N., 2006, Environmental monitoring of benzene and toluene produced in indoor air due to combustion of biomass fuels, Science Total Environment, 357, (1- 3), 280-287. (If=4.948. ci=49) 5. Sukesh Narayan Sinha, V.K. Bhatnagar, G. S. Tuteja, N. P. Agnihotri, R. L. Kalra, 2011, A novel method for pesticides analysis in refined sugar samples using GC-MS/MS and solvent extraction method, Food chemistry, 126, 379-386. (If=4.946, ci=35) 6. Sukesh Narayan Sinha , M. Vishnu Vardhana Rao, K. Vasudev, 2012, Distribution of pesticides in different commonly used vegetables from Hyderabad, India, Food Research International 45, 161–169 (If=4.196, ci=30) 7. Sukesh Narayan Sinha, M. Vishnu Vardhana Rao, K. Vasudev, Martins Odetokun, 2012, A liquid chromatography mass spectrometry-based method to measure organophosphorous insecticide, herbicide and non-organophosphorous pesticide in grape and apple samples, Food Control 25, 636-646. (If=3.891, ci=25) 8. Sukesh Narayan Sinha , K. Vasudev , M. Vishnu Vardhana Rao, 2012, Quantification of organophosphate insecticides and herbicides in vegetable samples using the ‗‗Quick Easy Cheap Effective Rugged and Safe‘‘ (QuEChERS) method and a high-performance liquid chromatography–electrospray ionisation–mass spectrometry (LC–MS/MS) technique, Food Chemistry 132, 1574–1584 (if=4.946, ci=54) 9. Sukesh Narayan Sinha, Paritosh K. Kar, Shyam Perugu, U.V. Rama Krishna, C.P. Thakur, 2016, Adefovir dipivoxil—A possible regimen for the treatment of dengue virus (DENV) infection, Chemometrics and Intelligent Laboratory Systems 155, 120– 127 (if=2.701, ci= 2) 10. Dewan A., Bhatnagar, V.K., Mathur, M.L., Chakma, T., Kashyap, R., Sadhu, G. H., Sinha, S.N., Saiyed, H. N: Repeated Episodes of Endosulfan Poisoning. Clinical Toxicology, 2004, 42 (if=4.381, ci=44)

382

SRIVASTAVA, ACHAL KUMAR (b 1966), Professor, Department of Neurology, All India Institute of Medical Science, New Delhi


Dr. Achal Kumar Srivastava completed his MBBS, MD (Medicine) from M.L.N. Medical College, Allahabad and DM (Neurology) from All India Institute of Medical Sciences, New Delhi. He heads the Clinical Neurophysiology facility and Ataxia clinic at the center and is a member of the Comprehensive Epilepsy care team. He has received Young investigator award for CAG triplet repeat disorder conferences at USA and Italy. He is a recipient of more than 25 paper presentation awards and has more than 80 publications to his credit. He has received outstanding paper presentation award from AINA at American Academy of Neurology conference at San Francisco in 2004. He has keen interest in teaching and has provided guidance and training to more than 70 DM and PhD students in their research work. He has received best paper award at Neurological Society of India conference at Hyderabad in 1998. He is Editorial board member and Reviewer of several International Journals of repute. Dr. Srivastava was Organizing/Co-Organizing Secretary, Treasurer in various national and international conferences/symposiums. He is executive member of Delhi Neurological Association and Neurological Society of India. He is member of National Academy of Medical Sciences. For over 18 years he has done landmark work in the field of ataxias in India and has created a database of around 3500 pedigrees including largest series of SCA patients.

Proposer: Dr. M.V. Padma Srivastava, Seconder: Dr. Sanjeev Sinha


1. Srivastava AK, Takkar A, Garg A, Faruq M. 2017. Clinical behaviour of spinocerebellar ataxia type 12 and intermediate length abnormal CAG repeats in PPP2R2B. Brain 140 (Pt 1):27-36 (if=10.292, ci=9)

2. Faruq M, Magaña JJ, Suroliya V, Narang A, Murillo-Melo NM, Hernández-Hernández O, Srivastava AK, Mukerji M. 2017. A Complete Association of an intronic SNP rs6798742 with Origin of Spinocerebellar Ataxia Type 7-CAG Expansion Loci in the Indian and Mexican Population. Ann Hum Genet. Sep;81(5):197-204. (if=1.659, ci=4)

3. Singh I, Shakya S, Singh RK, Ahmad I, Goyal V, Shukla G, Srivastava MV, Faruq M, Srivastava AK. 2017. Iron related hemochromatosis (HFE) gene mutations in Friedreich Ataxia patients. Parkinsonism Relat Disord. 34:71-72. (if=4.484)

4. Singh I, Faruq M, Padma MV, Goyal V, Behari M, Grover A, Mukerji M, Srivastava AK. 2015. Investigation of mitochondrial DNA variations among Indian Friedreich's ataxia (FRDA) patients. Mitochondrion. 25:1-5. (if=3.704, ci=5)

5. Faruq M, Srivastava AK, Suroliya V, Kumar D, Garg A, Shukla G, Behari M. 2014. Identification of FXTAS presenting with SCA 12 like phenotype in India. Parkinsonism Relat Disord. 20 (10):1089-93. (if=4.484, ci=5)

6. Faruq M, Shakya S, Garg A, Srivastava AK. 2014. Spinocerebellar Ataxia 2 and 12 Mutations in an Indian Family with Cerebellar Ataxia and Slow Saccades. Mov Disord Clin Practice. 1 (3): 267-70. (ci=3)

7. Chakrabarty B, Kabra SK, Gulati S, Toteja GS, Lodha R, Kabra M, Pandey RM, Srivastava AK. 2013. Peripheral neuropathy in cystic fibrosis: a prevalence study. J Cyst Fibrosis. 12(6):754-60. (if=4.727, ci=11)

8. Swarup V, Srivastava AK, Padma MV, Moganty RR. 2013. Quantitative Profiling and Identification of Plasma Proteins of Spinocerebellar Ataxia Type 2 Patients. Neurodegenerative Diseases. 12(4):199-206 (if=2.842, ci=8)

9. Swarup V, Srivastava AK, Padma MV, Rajeswari MR. 2011. Quantification of circulating plasma DNA in Friedreich's ataxia and spinocerebellar ataxia types 2 and 12. DNA Cell Biol. 30(6):389-94 (if=2.236, ci=31)

10. Singh I, Faruq M, Mukherjee O, Jain S, Pal PK, Srivastav MV, Behari M, Srivastava AK, Mukerji M. 2010. North and South Indian populations share a common ancestral origin of Friedreich's ataxia but vary in age of GAA repeat expansion. Ann Hum Genetics. 74(3):202-10 (if=1.659, ci=16)

383

SULTANA, SARWAT (b 1955) Professor, Jamia Hamdard (Deemed to be University), New Delhi-110062


The previous research of Dr. Sarwat Sultana was on the isolation and identification of plant constituents with the help of sophisticated spectroscopic methods. She has isolated two novel compounds from the plant of Macaranga indica, as Macaflavone I and Macaflavone II, a new isoflavone from Afrormosia laxiflora for the first time in literature which are discussed in the book ’The Flavanoid’By T.J Mabry. At present she is working on the molecular mechanisms of natural compound used by indigenous system of medicine based on the available old literature Her work is on the signaling pathways in cancer induction and the amelioration of transcription factors for inflammation, proliferation and oxidative stress in animal models as well as in vitro models. She could also identify the important genes involved in prostate cancer using Micro Array and RTPCR techniques. Selective Androgen Receptor and Selective Estrogen Receptor Molecules from soya plants are used in amelioration of prostate cancer (13). The toxicity of TCE is attributed to the rapid intracellular free calcium (Ca2+) release, increases protein kinase C was reversed by Naringenin in HacaT cells. The inhibition of proliferation by augmenting immune surveillance, silencing acute inflammation, and inducing p53-mediated apoptosis of skin cancer by 3 promising medicinal extracts of Trigonella foenumgraecum, Eclipta Alba, and Calendula officinalis reduced the tumor number, incidence, and multiplicity of, which was confirmed by the pathologic studies that showed regressed tumors. She has shown polymorphism and epigenetic alterations in renal carcinogenesis in North Indians.

Proposer: Prof. B.C. Das, Seconder: Prof. M. Iqbal Ten Best Publications: 1. Mohammad Saleem, Aftab Alam, Shamsul Arifin, M.Shafi Shah, Bahar Ahmed and Sarwat Sultana. (2001) Lupeol, a triterpene inhibits early responses of tumor promotion induced by benzoyl peroxide in murine skin. Pharmacological Research 43, 127-134. (if=4.48, ci=98) 2. Mohammad Saleem, Mohammad Iqbal, Salah-uddin Ahmed, Aftab Alam and Sarwat Sultana. (2001) Tephrosia purpurea alleviates phorbol ester induced tumor promotion response in murine skin. Pharmacological Research 43(2), 135-144. (if=4.48, ci=38) 3. Naghma Khan, Sonia Sharma and Sarwat Sultana. (2004) Amelioration of Ferric Nitrilotriacetate (Fe-NTA) induced renal oxidative stress and tumor promotion response by Coumarin (1,2-benzopyrone) in Wistar rats. Cancer Letters 210 (1), 17-26 (if=6.347, ci=24) 4. Naghma Khan and Sarwat Sultana. (2005) Inhibition of Potassium bromate induced renal oxidative stress and hyperproliferative response by Nymphaea alba in Wistar rats. Journal of Enzyme Inhibition and Medicinal Chemistry (3):275-83. (if=4.293, ci=30) 5. Sarwat Sultana, Salahuddin Ahmed, Tamanna Jahangir and Sonia Sharma. (2005) Inhibitory effect of celery seeds extract on chemically induced hepatocarcinogenesis: modulation of cell proliferation, metabolism and altered hepatic foci development. Cancer Letters 221(1), 11-20 (if=6.347, ci=90) 6. Anuradha Sehrawat and Sarwat Sultana. (2006) Tamarix gallica ameliorates thioacetamide induced hepatic oxidative stress and hyperproliferative response in wistar rats. Journal of Enzyme Inhibition and Medicinal Chemistry 21(2), 215-23 (if=4.293, ci=25) 7. Sahar Rahman and Sarwat Sultana. (2007) Glycyrrhizin exhibits potential chemopreventive activity on TPA induced cutaneous oxidative stress and tumor promotion in Swiss albino mice. Journal of Enzyme Inhibition and Medicinal Chemistry 22(3), 363-9 (if=4.293, ci=37) 8. Rehan Khan, Abdul Quaiyoom Khan, Wajhul Qamar, Abdul Lateef, Mir Tahir, Farrah Ali, Muneeb U Rehman and Sarwat Sultana. (2011) Chrysin protects against cisplatin-induced colon toxicity via amelioration of oxidative stress and apoptosis: probable role of p38MAPK and p53. Toxicology and Applied Pharmacology 258(3): 315-29 (if=3.791, ci=66) 9. Mir Tahir, Muneeb U Rehman, Abdul Lateef, Abdul Q Khan, Rehan Khan, Wajhul Qamar, Oday O Hamiza, Farrah Ali, Syed K Hassan and Sarwat Sultana. (2013) Diosmin abrogates chemically induced hepatocarcinogenesis via alleviation of oxidative stress, hyperproliferative and inflammatory markers in murine model. Toxicology Letters 18; 220(3): 205-18 (if=3.858, ci=17) 10. Rehman MU, Tahir M, Khan AQ, Khan R, Lateef A, Oday-O-Hamiza, Qamar W, Ali F. and Sarwat Sultana. (2013) Chrysin suppresses renal carcinogenesis via amelioration of hyperproliferation, oxidative stress and inflammation: plausible role of NF-κB. Toxicology Letters. 216(2-3):146-58. (if=3.858, ci=63)

384

VERMA, MAHESH (b 1957), Director - Principal, Maulana Azad Institute of Dental Sciences, New Delhi


Prof. Mahesh Verma, Director-Principal, Maulana Azad Institute of Dental Sciences and currently officiating President, Dental council of India: has established one of the best Dental Institute cum Hospital in India, setting newer standards, par excellence. An awardee of Padamshree, Dr. B.C.Roy National Award in 2007 and ‘State Award’ by Delhi Govt., Dr. Verma has developed indigenous dental Implant under “New Millenium Indian Technology Leadership Initiative” of Govt of India. The Implant has been patented and human trials are on. Dr. Verma stands out as a professional of rare eminence, a leader in sensitizing and enlightening the people in the prevention of dental diseases and also providing medical care of highest level to the poor and underprivileged: thus a role model for the other professionals. In view of his extra ordinary and exceptional contribution to dental education and research we recommend his nomination for Fellowship of the Academy. Most deserving leader in his field in the country and his indecision in the academy would be a long term asset.

Proposer: Prof. S.K. Sarin, Seconder: Prof. K.C. Upadhyaya


1. Verma M, Kumari P, Gupta R, Gill S, Gupta A. Comparative evaluation of surface topography of tooth prepared using erbium, chromium: Yttrium, scandium, gallium, garnet laser and bur and its clinical implications. J Indian Prosthodont Soc. 2015 Jan-Mar (if=0.30)

2. Nanda A, Jain V, Manak K, Verma M. An alternative adhesive based technique of raising the occlusal vertical dimension. Indian J Dent Res. 2014 Jul-Aug;25(4):505-8 (if=0.33)

3. Gupta C, Verma M, Gupta R, Gill S.Telescopic overdenture for oral rehabilitation of ectodermal dysplasia patient. Contemp Clin Dent. 2015 Sep;6(Suppl 1):S258-61. (if=--)

4. Kumari P, Verma M, Sainia V, Gupta A, Gupta R, Gill S. Mini-Implants, Mega Solutions: A Case Series. J Prosthodont. 2015 Nov 30. doi: 10.1111/jopr.12382. (if=1.452)

5. Rani S, Verma M, Gill S, Gupta R. Comparative evaluation of bonding strength of computer aided machined ceramic, pressable ceramic, and milled metal implant abutment copings and effect of surface conditioning on bonding strength: An in vitro study. J (if=0.30)

6. Kumari P, Verma M, Sainia V, Gupta R, Gill S. Rehabilitation of resorbed mandibular ridges using mini implant retained overdentures: A case series with 3 year follow-up. J Indian Prosthodont Soc. 2016 Apr-Jun;16(2):221-6. (if=0.30)

7. Koli D, Kaur H, Nanda A, Verma M, Manak K, Gupta R, Gill S. Correction of Cheek biting in dentate patient. J Prosthet Dent. 2016 Aug;116(2):300-3. doi: 10.1016/j.prosdent. 2016. 01.012. Epub 2016 Mar 18 (if=1.46)

8. Verma M, Menghani S, Devi J, Gupta R, Gill S. A Novel Approach to Treat Traumatized Alveolar Ridges: Two Case Reports. Case Reports in Dentistry (2016), Article ID 9312412, http://dx.doi.org/10.1155/2016/9312412 (if=--)

9. Nanda A, Verma M. Cameo surface recording in complete denture fabrication using TENS: A clinical report. Journal of Prosthetic Dentistry. Accepted for publication Dec 2016. (if=1.46)

10. Devi J, Verma M, Gupta R. Assessment of treatment response to splint therapy and evaluation of TMJ function using joint vibration analysis in patients exhibiting TMJ disc displacement with reduction: A clinical study. Indian J Dent Res. 2017 Jan-Feb; (if=0.33)

385

BAJPAI, MINU (b 1958), Professor, Dept. of Paediatric Surgery, All India Institute of Medical Sciences, New Delhi


Prof. Bajpai has applied molecular studies to clinical research focused on renal diseases affecting children. Although 40-50% hydronephrosis diagnosed antenatally are due to pelviureteric junction obstruction, yet, there is no consensus on defining obstruction and on the optimal management of these patients due to technical limitations in accurately quantifying the degree of obstruction at the uretero-pelvic junction. These children require repeated follow-up investigations before a final diagnosis could be confirmed. Such delay in treatment risks permanent renal injury. In their study Dr. Bajpai has demonstrated 6. that Plasma Renin Activity reflects obstructive stress and precedes parameters of actual renal injury, such as Split Renal Function and Glomerular Filtration Rate. It was reduced and stabilized in all children after surgery. Thus this molecule serves as the critical discriminatory factor between patients who would benefit from medical versus surgical treatment & an early marker, also, with respect to management and prognosis in children with Reflux Nephropathy. His publications formed the basis for recognition of this activated molecule in foetal stage by the Obstetricians in Europe & several centres in USA, such as-Johns Hopkins Institute, Baltimore. The details of this work are available in his 3 Global First reports. His report is the first on Indian Children that ‘D’ allele may be one of the genetic susceptibility factors contributing to adverse renal prognosis in patients with congenital uropathies. The usefulness of genotype extends beyond prognostication & to identification of patients who may benefit from angiotensin converting enzyme inhibitors and angiotensin II antagonists.

Proposer: Prof. Chitra Sarkar, Seconder: Prof. Sanjeev Sinha


1. Bajpai M, Bal CS, Tripathi M, Kalaivani M, Gupta AK. Prenatally diagnosed unilateral hydronephrosis: prognostic significance of plasma renin activity. The Journal of urology. 2007: 178(6); 2580-2584. (if=5.157, ci=11)

2. Bajpai M, Puri A, Tripathi M, Maini A. Prognostic significance of captopril renography for managing congenital unilateral hydronephrosis. The Journal of urology. 2002: 168(5); 2158-2161. (if=5.157, ci=23)

3. Bajpai M, Chandrasekharam VVSS. Nonoperative management of neonatal moderate to severe bilateral hydronephrosis. The Journal of urology. 2002: 167(2); 662-665. (if=5.157, ci=50)

4. Bajpai M, Pal K, Bal CS, Gupta AK, Pandey RM. Role of plasma renin activity in the management of primary vesicoureteric reflux: A preliminary report. Kidney international. 2003: 64(5); 1643-1647 (if=8.395, ci=12)

5. Bajpai M, Bal CS, Kumar R, Chaturvedi PK, Kalaivani M, Gupta AK. Persistent renin-angiotensin system activation after anti-reflux surgery and its management. Journal of pediatric urology. 2011: 7(6); 616-622. (if=3.145, ci=4)

6. Bajpai M, Dave S, Gupta DK. Factors affecting outcome in the management of posterior urethral valves. Pediatric surgery international. 2001: 17(1); Nov-15. (if=1.181, ci=46)

7. Bajpai M, Pratap A, Tripathi M, Bal CS. Posterior urethral valves: preliminary observations on the significance of plasma renin activity as a prognostic marker. The Journal of urology. 2005: 173(2); 592-594. (if=5.157, ci=13)

8. Bajpai M, Pratap A, Somitesh C, Tyagi J. Angiotensin, February 2004, Converting enzyme gene polymorphism in Asian Indian Children with congenital uropathies. J Urol., 171 (2 Pt 1): 838-40. (if=5.157, ci=13)

9. Barik M, Bajpai M, Patnaik S, Mishra P, Behera P, Dwivedi SN, July 2016, Development of new method and protocol for cryopreservation related to embryo and oocytes freezing in terms of fertilization rate: A comparative study including review of litera (if=5.175, ci=1)

10. Barik M, Bajpai M, Malhotra A, Samantaray JC, Dwivedi S, Das S., July-September 2015, Novel mutation detection of fibroblast growth factor receptor 1 (FGFR1) gene, FGFR2IIIa, FGFR2IIIb, FGFR2IIIc, FGFR3, FGFR4 gene for craniosynostosis: A prospective (if=4.840, ci=4)

386

BAL, CHANDRA SEKHAR (b 1960), Professor & Head, Department of Nuclear Medicine, AIIMS, New Delhi 110029


Dr Chandrasekhar Bal who works as Professor and Head of the Department of Nuclear Medicine at All India Institute of Medical Sciences, New Delhi has made outstanding contributions in the field of Nuclear Medicine. His overall impact is very strong in the practice of nuclear medicine, teaching and research. Dr Bal has started DM Programme in Therapeutic Nuclear Medicine at AIIMS, New Delhi for the first time in the World. This programme is envisaged as path-breaking in radionuclide therapy and shall encourage many youngsters to choose a career dedicated to further develop the radionuclide Therapy in India that is now available only in a few metropolitan cities. On the basis of his contributions in the field of Thyroid Cancer Research, two recommendations have been changed in the American Thyroid Association (ATA2015) Guidelines on Thyroid Cancer: one on “Low-dose Radioiodine Ablation” and other one is on “Lobar Ablation”. In order to fulfil the man-power needs of the country, Dr Bal was instrumental in starting MD (Nuclear Medicine) at AIIMS in 1996, MSc (Nuclear Medicine Technology) in 2003 and DM in 2015. The PhD programme of the department is at full swing, currently where 4 students are enrolled under his guidance. He has made a large number of publications with 390 papers in peer reviewed journals with total citations of 3910. His current h-index is 31 and i10-index is 120. He has introduced peptide-based radionuclide PET imaging and therapy in India. This being practiced in many institutions and hospitals in the country.

Proposer: Prof. T P Singh, Seconder: Prof. Chitra Sarkar


1. C Bal, AK Padhy, S Jana, GS Pant, AK Basu 1996 Prospective randomized clinical trial to evaluate the optimal dose of 131I for remnant ablation in patients with differentiated thyroid carcinoma. Cancer 77(12); 2574-2580. Impact Factor of CANCER: 5 (if=CANCER: 5.649, ci=Google Scholar 192; Web of Science 101)

2. CS Bal, A Kumar, GS Pant 2004 Radioiodine dose for remnant ablation in differentiated thyroid carcinoma: a randomized clinical trial in 509 patients. The Journal of Clinical Endocrinology & Metabolism 89(4); 1666-1673. (if=JCEM: 6.206 , ci=Google Scholar 175; Web of Science 86)

3. NK Gowda, D Agrawal, C Bal 2006 Technetium Tc-99m ethyl cysteinate dimer brain single-photon emission CT in mild traumatic brain injury: a prospective study. Am J Neuroradiology 27(2); 447-451 (if=AJNR: 3.124, ci=Google Scholar 92; Web of Science 52)

4. R Goswami, CS Bal, S Tejaswi, GV Punjabi, A Kapil, N Kochupillai 2001 Prevalence of urinary tract infection and renal scars in patients with diabetes mellitus. Diabetic Research and Clinical Practice 53(3); 181-186 (if=DRCP: 3.045, ci=Google Scholar 91; Web of Science 23)

5. CS Bal, A Kumar, RM Pandey 2002 A randomized controlled trial to evaluate the adjuvant effect of lithium on radioiodine treatment of hyperthyroidism. Thyroid 12(5); 399-405. (if=THYROID”: 4. 493, ci=Google Scholar 83; Web of Science 31)

6. JA Sosa, R EElisei, B Jarzab, J Balkissan, S Lu, C Bal, S Marur, A Gamza 2014 Randomized safety and efficacy study of fosbretabulin with paclitaxel/carboplatin against anaplastic thyroid carcinoma. Thyroid 24(2)-232-240. (if=“THYROID”: 4. 493, ci=Google Scholar 55; Web of Science 35)

7. CS Bal, A Kumar, P Chandra, SN Dwivedi 2004 Is chest x-ray or high-resolution computed tomography scan of the chest sufficient investigation to detect pulmonary metastasis in pediatric differentiated thyroid cancer. Thyroid 14(3); 217-225 (if= “THYROID”: 4. 493, ci=Google Scholar 54; Web of Science 22)

8. N Naswa, P Sharma, R Kumar, S Chumber, C Bal 2011 Gallium-68-DOTA-NOC PET/CT of patients with gastroenteropancreatic neuroendocrine tumors: a prospective single-center study. Am J Rontgenology. Am J Rontgenology 197; 1221-1228 (if= “AJR” : 2. 775, ci=Google Scholar 71; Web of Science 43)

9. A Kumar, DN Srivastava, TTM Chau, HD Long, CS Bal 2007 Inoperable Hepatocellular Carcinoma: Transarterial 188Re HDD–Labeled Iodized Oil for Treatment —Prospective Multicenter Clinical Trial. Radiology 243(2); 509-519. (if=“Radiology” : 6.867, ci=Google Scholar 50; Web of Science 25)

10. Bal C, Kumar A Tripathi M, Chandrashekar N, Phom H, Murli NR, Prem Chandra, Pant GS 2005 High-dose radioiodine treatment for differentiated thyroid carcinoma is not associated with change in female fertility or any genetic risk to the offspring. (if=Red Journal: 4.258, ci=Google Scholar 40; Web of Science 20)

387

BANERJEE, SOMA (b 1970), Associate Professor, Institute of Post Graduate Medical Education and Research (IPGME&R), Kolkata


Dr. Banerjee’s research work exemplifies ‘Translational research on hepatitis B virus (HBV) mediated hepatocellular carcinoma (HCC) which is one of deadliest cancers worldwide, including India.’ Her important research contribution includes identification of early diagnostic and prognostic biomarkers for HCC from molecular analysis of accumulated mutations in the viral genome during disease progression. In addition, she also established differentially expressed liver tissue specific microRNAs as early diagnostic marker for HCC patients who are insensitive to α-feto protein (AFP), the well-known HCC biomarker. She, proposed a novel mechanism for viral sequence integration into human chromosome. Preferential integration of sequences from more oncogenic viral genotype in dual genotype infected HCC patients suggests importance of detection of viral antigens from both liver tissue and blood before withdrawing therapy. Her study has shown that during disease progression, the viral proteins are responsible for induction of myriads of genes including few novel genes and miRNAs that trigger chemo-resistance in cancer cells and it is responsible for disease recurrence after resection. Subsequently, a microRNA, targeting multiple genes from tumour microenvironment has been shown to have very strong potential as a therapeutic. Apart from viral mediated liver cancer, her research findings have significant impact in the prediction of high-risk alcoholic individuals who are likely to develop alcoholic liver diseases using disease associated single nucleotide polymorphisms. Hence, these findings will be useful in the clinics for the better management of hepatitis and HCC patients. I strongly recommend her to be considered for this prestigious fellowship.

Proposer: Prof. Susanta Roychowdhury, Seconder: Prof. Abhijit Chowdhury


1. Datta S, Dasgupta D, Ghosh A, Ghosh S, Manna A, Datta S, Chatterjee M, Chowdhury A, Banerjee S. 2018.Oncogenic Potential of Hepatitis B Virus Subgenotype D1 Surpasses D3: Significance in the development of Hepatocellular carcinoma. Carcinogenesis. 39(2):283-292. (if= 5.072, ci=nil)

2. Ghosh A, Dasgupta D, Ghosh A, Roychoudhury S, Kumar D, Gorain M, Butti R, Datta S, Agarwal S, Gupta S, Krishna Dhali G, Chowdhury A, Schmittgen TD, Kundu GC, Banerjee S. 2017. MiRNA199a-3p Suppresses Tumor Growth, Migration, Invasion and Angiogenesis in Hepatocellular Carcinoma by Targeting VEGFA, VEGFR1, VEGFR2, HGF and MMP2. Cell Death and Diseas (if= 5.638, ci= 40)

3. Ghosh A, Ghosh A, Datta S, Dasgupta D, Das S, Ray S, Gupta S, Datta S, Chowdhury A, Chatterjee R, Mohapatra SK, Banerjee S. 2016. Hepatic miR-126 is a Potential Plasma Biomarker for Detection of Hepatitis B Virus Infected Hepatocellular Carcinoma. International Journal of Cancer, Jun 1;138(11):2732-44. (if= 7.36, ci= 28)

4. Roy N, Dasgupta D, Mukhopadhyay I, Chatterjee A, Das K, Bhowmik P, Das S, Basu P, Santra AK, Datta S, Dhali GK, Chowdhury A, Banerjee S. 2016. Genetic Association and Gene-Gene Interaction Reveal Genetic Variations in ADH1B, GSTM1 and MnSOD Independently Confer Risk to Alcoholic Liver Diseases in India.PLoS One. Mar 3;11(3):e0149843. (if= 2.76, ci= 5)

5. Ghosh A, Ghosh S, Dasgupta D, Ghosh A, Datta S, Sikdar N, Datta S, Chowdhury A, Banerjee S. 2016.International Journal of Biological Sciences 12(1): 41-52. (if= 4.047, ci= 15)

6. Datta S, Ghosh A, Ghosh A, Roychowdhury S, Roy G, Das S, Das K, Gupta S, Basu K, Basu A, Datta S, Chowdhury A, Banerjee S. 2014. Novel point and combo-mutations in the genome of hepatitisB virus genotype D: Characterization an impact on liver disease progression to hepatocellular carcinoma. PloS One; 9(10): e110012. (if= 2.76, ci= 22)

7. Datta S, Roychoudhury S, Ghosh A, Dasgupta D, Ghosh A, Chakraborty B, Roy S, Gupta S, Santra AK, Datta S, Das K, Dhali GK, Chowdhury A, Banerjee S. 2014. Distinct distribution pattern of hepatitis B virus genotype C and D in liver tissue and serum of dual genotype infected liver cirrhosis and hepatocellular carcinoma patients. PLoS One. Jul 17; (if= 2.76, ci= 16)

8. Roy N, Mukhopadhyay I, Das K, Pandit P, Majumder PP, Santra A, Datta S, Banerjee S*, Chowdhury A*. 2012. Genetic variants of TNFα, IL10, IL1β, CTLA4 and TGFβ1 modulate the indices of alcohol-induced liver injury in East Indian population. Gene. Nov 1;509(1):178-88. (if= 2.498, ci= 19)

9. Banerjee S, Smith S, Oum JH, Liaw HJ, Hwang JY, Sikdar N, Motegi A, Lee SE, Myung K. 2008. Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination. J Cell Biol. Jun 30;181(7):1083-93. (if= 8.784, ci= 19)

10. Banerjee S, Smith S and Myung K. 2006. Suppression of Gross chromosomal Rearrangements by yKu70-yKu80 Heterodimer Through DNA damage checkpoints.Proc.Natl.Acad.Sci. USA, Feb 7; 103(6): 1816-1821. (if= 9.5, ci= 15)

388

BHUMA, VENGAMMA (b 1960), Senior preofessor & Head, Department of Neurology, Sri Venkateswara Institute of Medical Sciences, Tirupathi.


The nominee has contributed immensely to the starting of and development of Neurology as a specialty in the backward Rayalaseema area of Andhra Pradesh with best clinical,academic and research activities. The nominee’s work was instrumental in documenting the management practices and utilization of various medical services for epilepsy in different parts of India and also annual economic burden of epilepsy in India. She is involved in the new drug trials related to epilepsy. She published articles in the field of stroke and stem cell research and in the field of bioinformatics .Another pioneering venture undertaken by the nominee is organizing the care of epilepsy at a community level by initiating the “Monthly Free Epilepsy Camp” that is attended by more 450 patients every month where free antiepileptic medications are also given to patients. The successful uninterrupted run of this “Monthly Free Epilepsy Camp” for more than the last 13 years since 1999 incurring an expenditure of more than Rs 1 Crore is a testimony to the commitment, organization skills including financial and programmatic capability of Dr B. Vengamma.She has also shown that in patients with intermediate syndrome due to Organophosphorus compound poisoning, neuromuscular junctional dysfunction is the predominant factor for intermediate syndrome. Her research work has also established that disturbances in trace element homeostasis during the progression of Parkinson’s disease.The nominee is recognized as a postgraduate teacher and guide for tudents for 47 students since 2003

Proposer: Dr. Asha Juwarkar, Seconder: Prof U.C. Srivastava


1. Shailesh KK, Pais P, VengammaB, Muthane U. Clinical and electrophysiological study of intermediate syndrome in patients with organophosphorous poisoning. J Assoc Physicians India 1994;42:451-3 (if= 0.37, ci= 35)

2. Thomas SV, Sarma PS, Alexander M, Pandit L, Shekar L, Trivedi C, Vengamma B. Economic burden of epilepsy in India. Epilepsia 2001; 42:1052-60 (if=4.571, ci= 83)

3. Thomas SV, Sarma PS, Alexander M, Pandit L, Sekhar L, Trivedi C, Vengamma B. Epilepsy care in six Indian cities: a multicentre study on management and service. J Neurol Sci 2001;188:73-7 (if= 2.474, ci= 26)

4. Hegde ML, Shanmugavelu P, Vengamma B, Rao TS, Menon RB, Rao RV, Rao KS. Serum trace element levels and the complexity of inter-element relations in patients with Parkinson’s disease. J Trace Elem Med Biol 2004;18:163-71 (if=2.550, ci=79)

5. Damodaram P, Manohar IC, Prabath Kumar D, Mohan A, Vengamma B, Rao MH. Myasthenic crisis-like syndrome due to Cleistanthuscollinus poisoning. Indian J Med Sci 2008;62:62-4 (if= 0.62, ci=12)

6. Ramakrishna P,Naresh VVS, Chakrapani B, Vengamma B, Sivakumar V. Leptospirosis with acute renal failure and paraparesis. Indian J Nephrol 2008; 18:130-1 (if=0.55 , ci=8)

7. Ramakrishna P,Naresh VVS, Lakshmi AY, Vengamma B, Sivakumar V. Stroke in chronic kidney disease. Indian J Nephrol 2009;19:5-7.(if=0.55, ci=8)

8. Munikumar M, Priyadarshini IV, Pradhan D, Umamaheswari A, Vengamma B. Computational approaches to identify common subunit vaccine candidates against bacterial meningitis. Inter discip Sci 2013;5:155-64 (if=0.853, ci= 8)

9. Venkatesh K, Srikanth L, Vengamma B, Chandrasekhar C, Prasad BC, Sarma PV. In vitro transdifferentiation of human cultured CD34+ stem cells into oligodendrocyte precursors using thyroid hormones. Neurosci Lett 2015; 588:36-41. (if=(Impact Factor 2.026), ci=Cited by 6)

10. Sharma SK, Katoch VM, Mohan A, Kadhiravan T, Elavarasi A, Ragesh R, Nischal N, Sethi P, Behera D, Bhatia M, Ghoshal AG, Gothi D, Joshi J, Kanwar MS, Kharbanda OP, Kumar S, Mohapatra PR, Mallick BN, Mehta R, Prasad R, Sharma SC, Sikka K, Aggarwal S.S.( if=1.446, ci=6)

389

CHAKRABARTI, SASANKA (b 1954), Professor, ICARE Institute of Medical Sciences & Research, Purva Medinipur, WB


The nominee has been working in the areas of brain aging, Alzheimer's disease (AD) and Parkinson's disease (PD) for nearly two decades. He has demonstrated how mitochondrial impairment, synaptosomal changes, altered amyloid beta metabolism and learning and memory impairment in aging brain could be ameliorated by a combination of marketed drugs like N-acetylcysteine, α-lipoic acid, and α-tocopherol [Neurochem. Int. (2015) 95, 92-99, Exp. Gerontol. (2014) 50, 19-25]. These results have great translational value and could be potential remedies for age-associated brain deficit or even AD . His recent publication showing the beneficial effect of deferasirox, the iron-chelator used in thalassemia, in rescuing the age-dependent increase in β-amyloid production and accumulation in rat brain has also clear therapeutic implications in AD [J. Alzheimers Dis (2015) 49, 681-693.]. He has further shown in details how iron can alter amyloid beta homeostasis at multiple steps within SHSY5Y cells. In contrast to widely accepted view of amyloid β protein as toxic, he has shown in a detailed study a potential beneficial effect of amyloid beta protein [Free Radic. Biol. Med. 56,184-192] and interestingly several recent papers from other labs have also supported this. The nominee has also published several very interesting papers on the etiopathogenesis of Parkinson's disease using a cell-based model showing the important role of dopamine oxidation products, α-synuclein and mitochondria in neural cell death [BBA (2011) 1812, 663-673, J.Neurochem. (2014) 131, 868-877.] hinting at potential drug targets.

Proposer: Prof. Mitali Chatterjee, Seconder: Prof. M K Thakur


1. Khan F.H., Sen T., Maiti A.K., Jana S., Chatterjee U., Chakrabarti S. (2005) Inhibition of rat brain mitochondrial transport chain activity by dopamine oxidation ........ for Parkinson’s Disease. Biochim Biophys Acta; 1741: 65-74. (if=5.47, ci=google scholar 64)

2. Sen T., Sen N., Tripathy G., Chatterjee U., Chakrabarti S. (2006) Lipid peroxidation associated cardiolipin loss and membrane depolarization in rat brain mitochondria. Neurochem. Int. 49, 20-27. (if=3.26, ci=google scholar 75)

3. Sen T., Sen N., Jana S., Khan F.H., Chatterjee U., Chakrabarti S. (2007) Depolarization and cardiolipin depletion in aged rat brain mitochondria: relationship with oxidative stress and electron transport chain activity. Neurochem. Int. 50, 719-72. (if=3.26, ci=google scholar 61)

4. Banerjee K., Sinha M., Pham Lan C. L., Jana S., Chanda D., Cappai R., Chakrabarti S.(2010) α-Synuclein induced membrane depolarization and loss of phosphorylation capacity ...... in Parkinson’s disease. FEBS Lett. 584, 1571-1576. (if=3.62, ci=google scholar 62)

5. Jana S, Sinha M, Chanda D, Roy T, Banerjee K, Munshi S, Patro BS, Chakrabarti S (2011). Mitochondrial dysfunction mediated by quinone oxidation products of ...... pathogenesis of Parkinson's disease. Biochim. Biophys. Acta 1812, 663-673. (if=5.47, ci=google scholar 67)

6. Chattopadhyay M, Thakurta IG, Behera P, Ranjan KR, Khanna M, Mukhopadhyay S, Chakrabarti S (2011). Mitochondrial bioenergetics is not impaired in nonobese subjects with type 2 diabetes mellitus. Metabolism-Clinical and Experimental 60, 1702-1710. (if=5.77, ci=google scholar 29)

7. Chakrabarti S, Munshi S, Banerjee K, Thakurta IG, Sinha M, Bagh MB (2011). Mitochondrial dysfunction during brain aging : role of oxidative stress and modulation by antioxidant supplementation. Aging Dis. 2, 242-256. (if=4.64, ci=google scholar 69)

8. Sinha M., Bhowmick P., Banerjee A., Chakrabarti S.;(2013) Antioxidant role of amyloid β protein in cell free and .......... for the pathogenesis of Alzheimer disease. Free Radic. Biol. Med. 56,184-192. (if=5.60, ci=google scholar 18)

9. Khemka V K., Bagchi D., Bandyopadhyay K., Bir A., Chattopadhyay S., Chakrabarti S. (2014) Altered serum levels of adipokines and insulin in probable Alzheimer's disease. J. Alzheimers Dis. 41, 525-533. (if=3.73, ci=google scholar 43)

10. Aritri Bir, Oishimaya Sen, Shruti Anand, Vineet Kumar Khemka, Priyanjalee Banerjee, Roberto Cappai, Arghyadip Sahoo, Sasanka Chakrabarti (2014) α-Synuclein induced mitochondrial dysfunction in ......... Parkinson's disease. J.Neurochem. 131, 868-87 (if=4.08, ci=google scholar 28)

390

CHIPLUNKAR, SHUBHADA VIVEK (b 1954), Director-Advanced Center for Treatment Research & Education in Cancer-ACTREC, Navi Mumbai


Prof. S.V.Chiplunkar, Director, ACTREC is a well known Cancer Immunologist. Her research focusses on understanding immune dysfunctions in cancer patients and development of cell based therapy. She has done pioneering work in understanding the role of gamma delta T cells in tumor immunity. She demonstrated that these cells mediate anti-tumor cytotoxicity by recognition of heat shock proteins (hsp60/hsp70) expressed on oral/esophageal tumors and that patients with acute lymphoblastic leukemias with gamma delta TCR clonality have improved survival. She defined a novel mode of action of bisphosphonates through activation of gamma delta T cells which has relevance in understanding their role in breast cancer patients.Her group was the first to report the role of notch signaling in activation and effector functions of gamma delta T cells (Gogoi and Chiplunkar 2014). She showed that activated gamma delta T cells inhibit bone resorption and play an important role in controlling bone metastasis. A novel finding from her lab was that Tgamma delta17 subset contributes to tumor progression and angiogenesis. Her work have provided important leads in understanding basic gamma deltaT cell immunobiology and has important implications in cancer immunotherapy. She is currently studying the immuosuppressive networks in tumor microenvironment contributed by Regulatory T cells, MDSCs and mesenchymal stem cells. Her research work is internationally highly acclaimed.

Proposer: Dr. Sharmila A. Bapat, Seconder: Dr. Mohan R. Wani


1. Patil RS, Shah SU, Shrikhande SV, Goel M, Dikshit R, Chiplunkar SV. 2016. IL17 producing γδT cells induce angiogenesis and are associated with poor survival in gallbladder cancer patients. Int J Cancer. 139(4):869-81. doi: 10.1002/ijc.30134 (if=5.085, ci=2)

2. Dar AA, Pradhan TN, Kulkarni DP, Shah SU, Rao KV, Chaukar DA, D'Cruz AK, Chiplunkar SV. 2016. Extracellular 2'5'Oligoadenylate synthetase 2 (OAS2) mediates TCR CD3-ζ chain downregulation via caspase-3 activation in oral cancer. Immunology 147(2): (if=3.795 , ci=3)

3. Gogai D, Dar AA, Chiplunkar SV. 2014. Involvement of Notch in Activation and Effector Functions of gamma delta T cells. J Immunol. 192:2054-2062 (if=4.922 , ci=11)

4. Balakrishnan B, Indap MM, Singh SP, Krishna CM, Chiplunkar SV. 2014. Turbo methanol extract inhibits bone resorption through regulation of T cell function. Bone. 58:114-25. doi:10.1016/j.bone.2013.10.008 (if=3.973 , ci=4)

5. Patel S, Vetale S, Teli P, Mistry R, Chiplunkar SV. 2011. IL-10 production in non-small cell lung carcinoma patients is regulated by ERK P38 and COX2. J Cell Mol Med. 16(3):531-44. doi:10.1111/j.1582-4934.2011.01329.x (if=4.014 , ci=14)

6. Kulkarni D, Wadia P, Pradhan T, Pathak A, Chiplunkar SV. 2009. Mechanisms involved in the down-regulation of TCR chain in tumor versus peripheral blood of oral cancer patients. Int J Cancer. 124(7):1605-1613. (if=5.085 , ci=21)

7. Atre N, Thomas L, Mistry R, Pathak K, Chiplunkar SV. 2006. Role of nitric oxide in heat shock protein induced apoptosis of T cells. Int J Cancer. 119(6):1368-1376. (if=5.085 , ci=24)

8. Thomas MT, Badwe, RA, Deshpande, RK, Samant UC, Chipunkar SV. 2001. Role of adhesion molecules in recruitment of V 1 T cells from the peripheral blood to the tumor tissue of esophageal cancer patients. Cancer Immunol Immunother. 50(4):218-225 (if=3.941 , ci=20)

9. Thomas ML, Samant U, Deshpande RK, Chiplunkar SV. 2000. Gamma Delta T cells lyse autplogous and allogenic esophageal tumors: Involvement of heat shock proteins in the tumor cell lysis. Cancer Immunol Immunother. 48(11):653-659. (if=3.941 , ci=54)

10. Laad AD, Thomas LM, Fakih AR, Chiplunkar SV. 1999. Human T cells recognize heat shock protein - 60 on Oral tumour cells. Int J Cancer. 80(5):709-714. (if=5.085 , ci=66)

391

DAS, NILAY KANTI (b 1976) Professor, Bankura Sammilani Medical College, Bankura, WB


Skin is an unique form wrapping our body. It is easier to throw out excretory substances like sweat. But administration some drugs from outside nearly impossible. For example, in recent years, researchers found Diclofenac can penetrate the skin to some extent- it really became hot-pot. But more drug targets are necessary in case resistance develops. Dr. Nilay Kanti Das, an eminent dermatologist is working on developing drugs and their mechanism of action. Target diseases are- Post kala-azar Dermal Leishmainiasis (PKDL), Leprosy, Cutaneous Fungal Infection, Urticaria, Viral Warts and other dermatological conditions like Toxic epidermal necrolysis, granuloma pyogenicum. Dr Nilay Kanti Das is also working as key clinician in the basic immunological research on Post kala-azar Dermal Leishmainiasis (PKDL) and evaluating the etio-pathogenesis of PKDL. He is also involved in evaluating the genetic susceptibility of leprosy which is contributing to rise in leprosy cases in certain geographical pockets.

Proposer : Prof. Arunava Goswami, Seconder : Prof. Kaustuv Sanyal Ten Best Publications : 1. Mohanty S, Das A, Ghosh A, Sil A, Gharami RC, Bandyopadhyay D, Das NK†. (2017) Effectiveness, safety and tolerability of cyclosporine versus supportive treatment in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A record-based study. Indian J Dermatol Venereol Leprol. 2017 MayJun;83(3):312- 316. (if=2.229 ci=4) 2. Podder I, Bhattacharya S, Mishra V, Sarkar TK, Chandra S, Sil A, Pal S, Kumar D, Saha A, Shome K, Bandyopadhyay D, Das NK† (2017) Immunotherapy in viral warts with intradermal Bacillus Calmette-Guerin vaccine versus intradermal tuberculin purified protein derivative: A double-blind, randomized controlled trial comparing effectiveness and safety in a tertiary care center in Eastern India. Indian J Dermatol Venereol Leprol. 2017 MayJun;83(3):411 (if=2.229 ci=2) 3. Roy K, Sil A, Das NK†, Bandyopadhyay D. (2015) Effectiveness and safety of clofazimine and pentoxifylline in type 2 lepra reaction: a double-blind, randomized, controlled study. Int J Dermatol. 2015 Nov;54(11):1325- 32. (if=1.541 ci=4) 4. Ghosh S, Das NK*, Mukherjee S, Mukhopadhyay D, Barbhuiya JN, Hazra A, Chatterjee M. (2015) Inadequacy of 12-Week Miltefosine Treatment for Indian Post-Kala-Azar Dermal Leishmaniasis. Am J Trop Med Hyg. 2015 Oct; 93(4):767-9. (if=2.564 ci=10) 5. Lal NR, Sil A, Gayen T, Bandyopadhyay D, Das NK†. (2014) Safety and effectiveness of autoinoculation therapy in cutaneous warts: a double--blind, randomized, placebo--controlled study. Indian J Dermatol Venereol Leprol. 2014 NovDec;80(6):515-20. (if=2.229 ci=11) 6. Debbarman P, Sil A, Datta PK, Bandyopadhyay D, Das NK† (2014) Autologous serum therapy in chronic urticaria: a promising complement to antihistamines Indian J Dermatol. 2014 Jul;59(4):375-82. (if=1.338 ci=19) 7. Mukhopadhyay D, Das NK*, De Sarkar S, Manna A, Ganguly DN, Barbhuiya JN, Maitra AK, Hazra A, Chatterjee M. (2012) Evaluation of serological markers to monitor the disease status of Indian post kala-azar dermal leishmaniasis. Trans R Soc Trop Med Hyg. 2012 Nov;106(11):668- 76. (if=2.820 ci=13) 8. Mukhopadhyay D, Das NK*, Roy S, Kundu S, Barbhuiya JN, Chatterjee M. (2011) Miltefosine effectively modulates the cytokine milieu in Indian post kala-azar dermal leishmaniasis. J Infect Dis. 2011 Nov;204(9):1427- 36. (if=5.186 ci=30) 9. Das NK*, Singh SK, Ghosh S, Sarkar A, Mukhopadhyay D, Roy S, Ganguly DN, Barbhuiya JN, Saha B, Chatterjee M. (2011) Case series of misdiagnosis with rK39 strip test in Indian leishmaniasis. Am J Trop Med Hyg. 2011 May;84(5):688-91. (if=2.564 ci=14) 10. Ganguly S, Das NK*, Panja M, Pal S, Modak D, Rahaman M, Mallik S, Guha SK, Pramanik N, Goswami R, Barbhuiya JN, Saha B, Chatterjee M. (2008) Increased levels of interleukin-10 and IgG3 are hallmarks of Indian post-kala-azar dermal leishmaniasis. J Infect Dis. 2008 Jun 15;197(12):1762- 71. (if=5.186 ci=57)

392

DASH, DEBABRATA (b 1958), Professor, Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi


The contributions of nominee over past three decades have carved him a niche in areas of translational nanomedicine and thrombosis. He is credited with design of novel theranostic platform that combines traditional thrombolytic therapy with state-of-the-art photothermal therapy (gold nanorods irradiated with near-infrared laser) for effective lysis of occlusive pathological thrombi with minimal bleeding complications, thus introducing a smart and safe thrombolytic regimen. Nominee has developed a sensitive impedance-based nano-biosensor to identify/screen individuals with high thrombotic risk. The sensor is based on detection of platelet-derived microparticles in drop of blood in high-risk individuals. Employing powerful bioenergetic screen nominee has demonstrated that, stimulated platelets switch their energy metabolism to aerobic glycolysis that led to design of small-molecule metabolic-modulators as novel anti-platelet/anti-thrombotic agents. He was first to demonstrate anti-thrombotic propensity of nanosilver for application in coronary stents. He reported thrombogenecity of graphene/nanodiamond and synthesized non-toxic nano-allotropes of carbon towards safe biomedical applications. Nominee asked the intriguing question ‘how platelets age?’ His study identified Proteasome and Sirtuins as components of “Internal Timer” regulating platelet life span, which can be therapeutic targets against thrombocytopenia. He validated RhoA-ROCK-MLC axis as anti-Alzheimer drug target. Research of nominee is high on translational scale, published in high-impact international journals and widely cited. Nominee is Fellow of Medical and Science Academies in country, recipient of ‘JC Bose National Fellowship’, ‘Tata Innovation Fellowship’, ‘National Research Award in Nano Science & Technology (DST/Nanomission), ‘Sun-Pharma Research Award’ and ‘CNR Rao Foundation Award’, and invited by Rashtrapati Bhavan for his outstanding research contributions.

Proposer: Prof. Arvind Mohan Kayastha, Seconder: Prof. Shyam Sundar


1. Kulkarni, P.P., Tiwari, A., Singh, N., Gautam, D., Sonkar, V.K., Agarwal, V. & Dash, D. (2019) Haematologica, 104: 1-12 (Aerobic glycolysis fuels platelet activation: small-molecule modulators of platelet metabolism as anti-thrombotic agents) (if=9.09, ci=Not available)

2. Singh, N., Varma, A., Verma, A., Maurya, B.N. & Dash, D. (2016), Nano Res. 9: 2327-2337 (Relief from vascular occlusion using photothermal ablation of thrombus with a multimodal perspective) (cited by ‘Nature India’) (if=8.893, ci=16)

3. Kumari, S., Chaurasia, S.N., Nayak, M.K., Mallick, R.L. & Dash, D. (2015) J. Biol. Chem. 290: 12290-12299 (Sirtuin inhibition induces apoptosis-like changes in platelets and thrombocytopenia) (Complimentary letter by the Editor) (cited by ‘Nature India’) (if=4.258, ci=23)

4. Kailashiya, J., Singh, N., Singh, S.K., Agrawal, V. & Dash, D. (2015) Biosens. Bioelectron. 65: 274-280 (Graphene oxide-based biosensor for detection of platelet-derived microparticles: a potential tool for thrombus risk identification) (cited by ‘Nature India’)(if=7.476, ci=41)

5. Sonkar, V.K., Kulkarni, P.P. & Dash, D. (2014) FASEB J. 28: 1819-1829 (Amyloid β peptide stimulates platelet activation through RhoA-dependent modulation of actomyosin organization) (cited by ‘Nature India’) (if=5.595, ci=30)

6. Kumari, S., Singh, M. K., Singh, S. K., Gracio, J.J.A. & Dash, D. (2014) Nanomedicine 9: 427-440 (Nanodiamond activates blood platelets and induces thromboembolism) (if=5.236, ci=34)

7. Nayak, M.K., Kulkarni, P.P. & Dash, D. (2013) J. Biol. Chem. 288: 6826-6834 (Regulatory role of proteasome in determination of platelet life span) (cited by ‘Nature India’) (if=4.258, ci=44)

8. Singh, S. K., Singh, M. K., Kulkarni P. P., Sonkar V. K., Grácio, J.J.A. & Dash, D. (2012) ACS Nano, 6: 2731-2740 (Amine-modified graphene: Thrombo-protective safer alternative to graphene oxide for biomedical applications) (if=13.709, ci=435)

9. Singh, S.K., Singh, M.K., Nayak, M.K., Kumari, S., Shrivastava, S., Grácio, J.J.A. & Dash, D. (2011) ACS Nano, 5: 4987-4996 (Thrombus inducing property of atomically thin graphene oxide sheets) (if=13.709, ci=290)

10. Shrivastava, S., Bera, T., Singh, S.K., Singh, G., Ramachandrarao, P. & Dash, D. (2009) ACS Nano, 3: 1357-1364 (Characterization of anti-platelet properties of silver nanoparticles) (Complimentary letter by the Editor) (cited by ‘Nature India’ and ‘Science Now’) (The publication was press-released in USA by American Chemical Society) (if=13.709, ci=305)

393

DEEPAK, KISHORE KUMAR (b 1958), Prof. & Head, Departemnt of Physiology, All India Institute of Medical Sciences, New Delhi.


Dr KK Deepak contributed in the field of Autonomic research, Non-pharmacological interventions and biomedical technology. He provided electro-encephalographic and clinical evidence of usefulness of meditation in drug resistant ecliptics In late 90s. Later he conducted the research on effect of Yogic interventions in irritable bowel syndrome (IBS). He showed that maximum beneficial effect was in diarrhea predominant IBS which underwent right nostril breathing intervention. He also published the effect of yoga in Inflammatory Bowel disease. His further studies showed the effectiveness of breathing exercises in diabetes mellitus and life style intervention in bronchial asthma. He also worked on EMG biofeedback intervention in hand dystonia. He established the Autonomic Function Lab in the Department of Physiology in 1989. He investigated the effect of several physiological manoeuvres on autonomic functions. Under his supervision more than 40 disease states have been investigated for autonomic and vascular dysfunctions. This resulted in the regular facility in the department for the assessment of autonomic and vascular function testing for referred patients. He has also carried out research in biomedical signal processing for autonomic functioning and validation of indigenous devices in collaboration with technology institutions. He contributed significantly in the field of medical education through research and training. His philosophy has been to translate physiology into clinical application. He has published 121 research papers in journals and 14 chapters in various books.

Proposer: Dr. Y.K. Gupta, Seconder: Dr. Subrat K. Acharya


1. Deepak KK, Manchanda SK, Maheshwari MC. Meditation improves clinicoelectroencephalographic measures in drug-resistant epileptics. Biofeedback and Self-regulation 1994; 19 (1); 25-40 [PMID: 8167162]. (if=1.84, ci=77)

2. Sihota R, Gupta V, Agarwal HC, Pandey RM, Deepak KK. Comparison of symptomatic and asymptomatic, chronic, primary angle-closure glaucoma, open-angle glaucoma, and controls. J Glaucoma 2000 Jun;9(3):208-213. [PMID: 10877370] (if=1.86, ci=49)

3. Taneja I, Deepak KK, Poojary G, Acharya IN, Pandey RM, Sharma MP. Yogic versus conventional treatment in diarrhea-predominant irritable bowel syndrome: a randomized control study. Applied psychophysiology and biofeedback 2004, 29 (1), 19-33 [PMID: 15 (if=1.84, ci=117)

4. Mittal CM, Wig N, Mishra S, Deepak KK. Heart Rate Variability is depressed in human-immuno deficiency virus (HIV) positive individuals. Int J of Cardiology. 2004; 94:1-6. [PMID: 14996467]. (if=4.03, ci=41)

5. Vempati R, Bijlani RL, Deepak KK. The efficacy of a comprehensive lifestyle modification programme based on yoga in the management of bronchial asthma: a randomized controlled trial. BMC Pulm Med. 2009 Jul 30; 9:37. (if=2.76, ci=109)

6. Sharma P, Makharia G, Ahuja V, Dwivedi SN, Deepak KK. Autonomic dysfunctions in patients with inflammatory bowel disease in clinical remission. Dig Dis Scis. 2009; 54:853–861 [PMID 18712478]. (if=2.26, ci=39)

7. Mukherjee S, Tripathi M, Chandra PS, Yadav R, Choudhary N, Sagar R, Rafia B, Pandey RM, Deepak KK. Cardiovascular autonomic functions in well-controlled and intractable partial epilepsies. Epilepsy Res. 2009; 85(2-3):261-9. [PMID: 19409754]. (if=2.52, ci=69)

8. Misra A, Nigam P, Hills AP, Chadha DS, Sharma V, Deepak KK et al. Consensus physical activity guidelines for Asian Indians. Diabetes technology & therapeutics 2012; 14(1):83-98. [PMID: 21988275] DOI: 10.1089/dia.2011.0111 (if=2.18, ci=41)

9. Chandran DS, Ali N, Jaryal AK, Jyotsna VP, Deepak KK. Decreased autonomic modulation of heart rate and altered cardiac sympathovagal balance in patients with Cushing’s syndrome: Role of endogenous hypercortisolism. Neuroendocrinology. 2013;97(4):309- (if=2.58, ci=08)

10. Kaur M, Chandran D, Lal C, Bhowmik D, Jaryal AK, Deepak KK, Agarwal SK. Renal transplantation normalizes baroreflex sensitivity through improvement in central arterial stiffness. Nephrol Dial Transplant. 2013 Oct; 28(10):2645-55. doi:10.1093/ndt/gft09 (if=3.85, ci=13)

394

GHOSH, DEEPA (b 1967), Scientist F, Institute of Nano Science and Technology, Mohali


I have been following Dr.Ghosh’s scientific progress for the past 15 years. Her contribution in the development of tissue engineered products at Reliance Life Sciences is laudable. Under her guidance, her group had developed several novel tissue engineered products for the treatment of skin related ailments, cartilage and muscle repair. Many of these products have completed phase-2 trials. Her contribution in this field has been acclaimed and she has been honoured with the prestigious NASI-Reliance award for innovation (2012). The department of Biotechnology had recognized her work and provided support to conduct clinical trials on a tissue engineered cartilage substitute. In her pursuit of developing affordable wound management products, she has developed for the first time in India, low cost hydrogel-based advanced wound management products. These are currently marketed under the ReliHeal® range of products. She was instrumental in the development of a fast-acting thrombin-based haemostat, ReliStat® which is currently used in surgeries to stop bleeding. . During the course of her developmental activities, she has gained immense experience in understanding the medical needs of our country. Her focus on developing low cost therapies for addressing the needs of common man is worth mentioning. Her expertise to take the technology from “bench to bedside” is reflected by the number of products that have been marketed or tested in clinical trials. While her product and design patents demonstrate the novelty of her work, her publications in high impact peer reviewed journals reflect her contribution in the area of basic research.

Proposer: Prof. Swapan Ghosh, Seconder: Prof. Ashok Ganguli


1. P. Kuchroo, V. Dave, A. Kumar, C. Viswanathan and D. Ghosh* (2015) Paracrine factors secreted by umbilical cord-derived MSCs induce angiogenesis in vitro by a VEGF-independent pathway. Stem Cells and Development 24(4): 437-450. (if=4.1, ci=13)

2. A. Das, A.Kumar, N.Patil, C. Viswanathan and D. Ghosh* (2015) Preparation and characterization of silver nanoparticle loaded amorphous hydrogel of carboxymethylcellulose for infected wounds. Carbohydrate Polymers 130, 254–261. (if=5.22, ci=7)

3. D. Ghosh*, P.Kuchroo, C.Viswanathan, S.Sachan, B.Shah, D.Bhatt, S.G.Parasramani and S.Savant (2012). Efficacy and safety of Autologous Cultured Melanocytes delivered on Poly (DL-lactic acid) film (ReliDerm®M) in the treatment of Stable Vitiligo (if=1.86, ci=5)

4. M. Deshpande, S. Tipnis, P. Shetty, D. Ghosh and C. Viswanathan, (2010) Immunologic properties of human dermal fibroblasts. Human Immunology vol. 71, 1089-1098. (if=2.87, ci=7)

5. D. Ghosh*, S. Shenoy and P. Kuchroo. (2008) Cultured Melanocytes: From skin biopsy to transplantation. Cell Transplantation, 17(3):351-60. (if=6.2, ci=10)

6. D. Thaloor, J. Gephardt, K. Miller and GK.Pavlath (1999) Systemic administration of the NF-kappa B inhibitor curcumin stimulates muscle regeneration after traumatic injury. Am.J. Physiol. 277(2 Pt 1):C320-C329 (if=7.65, ci=154)

7. K. Miller, D. Thaloor, S. Matteson and GK. Pavlath. (1999) Hepatocyte Growth Factor induces myoblast proliferation but inhibits its differentiation in vivo. Am J Physiol Cell Physiol. Jan; 278 (1):C174-81 (if=4.01, ci=205)

8. D. Thaloor, AK. Singh, GS. Sidhu, PV. Prasad, H.Kleinman and RK.Maheshwari.(1998) Inhibition of angiogenic differentiation of human umbilical vein endothelial cells by Curcumin. Cell Growth and Differentiation 9(4):305-312 (if=4.69, ci=207)

9. GK. Pavlath, D. Thaloor, TA. Rando, M. Cheong, AW. English and B.Zheng. (1998) Heterogeneity among muscle precursor cells in adult skeletal muscles with differing regenerative capacities. Developmental Dynamics 212:495-508 (if=2.59, ci=126)

10. GS. Sidhu, AK. Singh, D. Thaloor, KK. Banaudha, G. Patnaik, RC. Srimal and RK.Maheshwari. (1998) Enhancement of Wound Healing by Curcumin in animals. Wound Repair and Regeneration 6(2) 167-77 (if=2.757, ci=221)

395

HARINARAYAN, CHITTARI VENKATA (b 1957), Director, Institute of Endocrinology, Diabetes, Thyroid and Osteoporosis Disorders, Sakra World Hospitals, Sy No 52/2 & 53/3, Deverabeesanahalli (opp Intel, Outer Ring Road), Varathur Hobili, Marathahalli, Bangalore 560103, Karnataka State


Dr. Harinarayan first documented 25OH-Vitamin D(25OHD) deficiency as the predominant cause for radiological bone changes in Primary Hyperparathyroidism in India. In the same work, he demonstrated Vitamin D deficiency, in apparently healthy individuals for the first time in the country. This striking observation contradicted the then existing impression of normal Vitamin D status in India – a tropical country. Now this observation has now been confirmed countrywide and Vitamin D deficiency is an important health problem in India. He conducted the first population survey in the country in Andhra Pradesh and documented low vitamin D status and low dietary calcium intake in south Indian population. He demonstrated by in-vitro “Ampoule Model” studies that by exposing 7- Dehydrocholesterol to sunlight on hourly basis the whole day and in various seasons all-round the year, previtamin D synthesis takes place. Hence we as Indians can synthesize enough vitamin D from the skin on exposure to sunlight between 11 am to 2 pm, by exposing 10 to 15% of body surface area for 15 to 30 minutes. He showed the improvement in pancreatic β-cell function with correction of 25OHD deficiency in vitamin D-deficient non diabetic subjects, fall in serum 25OHD levels in patients with anti-epileptic therapy irrespective of the type of drug used, even at therapeutic concentrations, impact of low vitamin D levels in thyroid bone disease, Vitamin D Receptor gene polymorphisms and hypovitaminosis D might predispose to multidrug resistant tuberculosis(MDR-TB) and may increase time to MDR-TB sputum smear negativity.

Proposer: Prof. Ravinder Goswami, Seconder: Prof. Sanjeev Sinha


1. Harinarayan CV, Ramalakshmi T, Prasad UV, Sudhakar D, Srinivasarao PVLN, Sarma KVS, Kumar EGTV (2007). High prevalence of low dietary calcium, high phytate consumption and vitamin D deficiency in healthy south Indians. Am J Clin Nutr; 85:1062-67 (if=6.770), ci=198 )

2. Harinarayan CV, Gupta N, Kochupillai N (1995). Vitamin D status in primary Hyperparathyroidism in Northern India. Clinical Endocrinology; 43:351-358. (if=6.209, ci=128 )

3. Kesavulu M M, Kameswar Rao B, Apparao Ch, E.G.T.V. Kumar, Harinarayan CV (2002). Effect of omega-3 fatty acids on lipid peroxidation and anti-oxidant enzyme status in type – 2 diabetes patients. Diabetes Metab; 28:20-26. (if=4.693, ci=119 )

4. Harinarayan CV (2005). Prevalence of vitamin D insufficiency in postmenopausal south Indian women. Osteop. Int; 16:397-402. (if=4.859, ci=162 )

5. Harinarayan CV, Kochupillai N, Madhu V, Gupta N and Meunier PJ (2006). Endemic Skeletal Flurosis in India. Fluorotoxic metabolic bone disease: an osteo-renal syndrome caused by excess fluoride ingestion in the tropics. Bone; 39:907-14. (if=3.736, ci=39 )

6. Harinarayan CV, Ramalakshmi and Venkata Prasad U (2004). High prevalence of low dietary calcium and low vitamin D status in healthy south Indians, Asia Pac J Clin Nutr;13(4):359-6 (if=1.35, ci=100 )

7. Harinarayan CV, Ramalakshmi T, Prasad UV, Sudhakar D (2008). Vitamin D status in Andhra Pradesh: a population based study. Indian J Med Res. 2008; 127(3):211-8. (if=1.446, ci=90 )

8. Rathored J, Sharma SK, Singh B, Banavaliker JN, Sreenivas V, Srivastava AK, Mohan A, Sachan A, Harinarayan CV, Goswami R (2012).Risk and outcome of multidrug-resistant tuberculosis: vitamin D receptor polymorphisms and serum 25(OH)D. Int J Tuber16( (if=2.130, ci=90 )

9. Menon B, Harinarayan CV (2010). The effect of anti epileptic drug therapy on serum 25-hydroxyvitamin D and parameters of calcium and bone metabolism – a longitudinal study. Seizure; 19(3):153-8. (if=2.059, ci=34 )

10. Chittari V. Harinarayan, Michael F Holick, Upadrasta V. Prasad, Palavali S. Vani and Gutha Himabindu (2013). Vitamin D status and sun exposure in India. Dermato Endocrinology; 5(1):130-141. http://dx.doi.org/10.4161/derm.23873. (if=2.048, ci=22 )

396

KAUR, INDU PAL (b 1965), Professor of Pharmaceutics, University Institute of Pharmaceutial Sciences, Panjab University, Chandigarh


Prof. Indu Pal Kaur has worked extensively in the area of nanostructured drug carrier systems. Her focus is to develop simple, novel, scalable, stable and safe products. She has produced >120 publications; with cumulative impact factor >300; total citations ~5700; H index 40. Novelty of the systems developed by her is referred in 3 granted and 20 filed patents in last ten years. Further, three of the novel technologies developed by her have been transferred to the industry. Briefly her research contributions include: i. Enhancing pharmacokinetic bioprofile of several (>20) drugs including antituberculars. ii. Developing nano-ocular drops, which can deliver therapeutics to posterior eye including retina. Her work on ophthalmics is cited in Goodman Gilman, (12th edition; 2010)- the ‘Bible‘ of Pharmacology iii. Designing probiotics to withstand adverse physiological conditions, on topical or oral administration to improve response. iv. Upgrading phytochemicals (viz. curcumin, sesamol, ginger extract, green tea extract, NDGA, EGCG and catechin) from protectives to curatives by assigning a pharmaceutical couture to them, for diseases like Alzheimer`s, depression, cerebral ischemia, menopause, hepatic toxicity, photoageing, inflammation, cancers, ulcers, anxiety and chronic fatigue syndrome. v. Antiageing, anti-inflammatory, analgesic, wound-healing and antiinfective dermaceuticals. vi. Improving stability of molecules viz. siRNA, ketoconazole, rifampicin, curcumin, amphotericin B, atorvastatin, ATRA, vitamins. vii. Reducing toxicity and irritation of ATRA, antituberculars, capsaicin and phytochemicals. viii. Magnetic nanoparticles assisted detection of pathogens from water and food samples. ix. Expediting genotoxicity protocols (Ames test) and in vivo toxicity as per OECD guidelines for the pharmaceutical industry.

Proposer: Prof. Hirendra N. Ghosh, Seconder: Prof. Jatinder Vir Yakhmi


1. Kaur, I. P*., Singh, M., & Kanwar, M.2000. Formulation and evaluation of ophthalmic preparations of acetazolamide. International Journal of Pharmaceutics.199: 119-127 (if=3.994 , ci=132)

2. Kaur, I. P*., Smitha, R., Aggarwal, D., & Kapil, M. 2002. Acetazolamide: future perspective in topical glaucoma therapeutics. International Journal of Pharmaceutics. 248: 1-14 (if=3.994 , ci=167)

3. Geetha, T., Garg, A., Chopra, K., & Kaur, I. P*. 2004. Delineation of antimutagenic activity of catechin, epicatechin and green tea extract. Mutation Research/ Fundamental and Molecular Mechanisms of Mutagenesis. 556: 65-74 (if=3.581, ci=90)

4. Aggarwal, D., & Kaur, I. P*. 2005. Improved pharmacodynamics of timolol maleate from a mucoadhesive niosomal ophthalmic drug delivery system. International Journal of Pharmaceutics. 290: 155- 159 (if=3.994, ci=214)

5. Aggarwal, D., Pal, D., Mitra, A. K., & Kaur, I. P*.2007. Study of the extent of ocular absorption of acetazolamide from a developed niosomal formulation, by microdialysis sampling of aqueous humor. International Journal of Pharmaceutics. 338:21-26. (if=3.994, ci=88)

6. Kakkar, V., Singh, S., Singla, D., & Kaur, I. P*. 2011.Exploring solid lipid nanoparticles to enhance the oral bioavailability of curcumin. Molecular Nutrition & Food Research.55:495-503 (if=4.551, ci=228)

7. Bhandari, R., & Kaur, I. P*. 2013. Pharmacokinetics, tissue distribution and relative bioavailability of isoniazid-solid lipid nanoparticles. International Journal of Pharmaceutics. 441:202-212 (if=3.994, ci=89)

8. Kakkar, V., Muppu, S. K., Chopra, K., & Kaur, I. P*.2013. Curcumin loaded solid lipid nanoparticles: an efficient formulation approach for cerebral ischemic reperfusion injury in rats. European Journal of Pharmaceutics and Biopharmaceutics. 85:71. (if=3.975, ci=89)

9. Singh, M., Aranguez, A.I.G., Hussain, A., Srinivas, S.S., Kaur, I.P. 2018. Solid lipid nanoparticles for ocular delivery of isoniazid: evaluation, proof of concept and in vivo safety & kinetics. Nanomedicine. 4: 465-491. (if=5.05, ci=0)

10. Bansal, S., Singh, J., Kumari, U., Kaur, I.P., Barnwal, R.P., Kumar, R., Singh, S., Singh, G., Chatterjee, M. 2019. Development of biosurfactant-based graphene quantum dot conjugate as a novel and fluorescent theranostic tool for cancer. International Journal of Nanomedicine. 14: 809–818 (if=5.154, ci=0)

397

KUMAR, RAKESH (b 1965), Professor & Head, Diagnostic Nuclear Medicine Division, Department of Nuclear Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi


Dr. Rakesh Kumar, Professor & Head of the Diagnostic Nuclear Medicine Division, Nuclear Medicine at AIIMS, New Delhi. He has been actively involved in research and teaching for the last 24 years at this institute. He has 466 publications in the ‘PUBMED’ indexed journals with more than 7800 citations. He has 45 H-Index publications. He has delivered 142 CME lectures at conferences. He has been guide/co-guide to 160 post graduate MD/MS/DM/MCH/PhD students and has published 35 book chapters. He was ‘Guest Editor' of 4 issues of prestigious “PET Clinics” published by Elsevier. He has been “Editor” of Indian Journal of Nuclear Medicine since 2008. Dr Kumar has received 15 international and 5 national awards. He has also been honored with the Fellowship of National Academy of Medical Sciences (FAMS). Prof Kumar has been awarded with Hari Om Ashram Alembic Research Award-2015 by MCI presented by honourable President of India. His original contribution is developing the PET/CT guided biopsy using robotic arm. This is first in the world and has received “First Prize” at Salt Lake City, USA. His group was first to show various clinicopathologic factors associated with false negative PET results in breast cancer(Breast Cancer Res Treat. 2006;98:267-74). Using PET/CT his team has designed a new PET/CT technique for evaluation of inflammatory bowel diseases and urinary bladder cancer (Eur J Nucl Med Mol Imaging. 2007;34:2106-14, 2010;37:714-21 and 2013;40:386-93). He has also provided new definition for the detection of ectopic gastric mucosa which is now accepted worldwide(BrJRadiol2005;78:714-20).

Proposer: Dr. Pramod Kumar Garg, Seconder: Dr. Ravinder Goswami


1. Kolla SB, Aggarwal S, Kumar A, Kumar R, Chumber S, Parshad R, Seenu V. Early versus delayed laparoscopic cholecystectomy for acute cholecystitis: a prospective randomized trial. Surg Endosc. 2004 Sep;18(9):1323-7. (if=269, ci=3.7)

2. Kumar R, Xiu Y, Yu JQ, Takalkar A, El-Haddad G, Potenta S, Kung J, Zhuang H, Alavi A. (2004) 18F-FDG PET in evaluation of adrenal lesions in patients with lung cancer. J Nucl Med.;45(12):2058-62. (if=218, ci=6.6)

3. Kumar R, Loving VA, Chauhan A, Zhuang H, Mitchell S, Alavi A. Potential of dual-time-point imaging to improve breast cancer diagnosis with (18)F-FDG PET. J Nucl Med. 2005 Nov;46(11):1819-24. (if=194, ci=6.6)

4. Kumar R, Basu S, Torigian D, Anand V, Zhuang H, Alavi A.(2008) Role of modern imaging techniques for diagnosis of infection in the era of 18F-fluorodeoxyglucose positron emission tomography. Clin Microbiol Rev.;21(1):209-24 (if=156, ci=21.25)

5. Kumar R, Chauhan A, Zhuang H, Chandra P, Schnall M, Alavi A. (2006) Clinicopathologic factors associated with false negative FDG-PET in primary breast cancer. Breast Cancer Res Treat. Aug;98(3):267-74. (if=152, ci=4.085)

6. R Kumar, S Jana, SI Heiba, M Dakhel, D Axelrod, B Siegel, S Bernik, (2003) Retrospective analysis of sentinel node localization in multifocal, multicentric, palpable, or nonpalpable breast cancer J Nucl Med 44 (1), 7-10 (if=147, ci=6.6)

7. Kumar R, Xiu Y, Zhuang HM, Alavi A.(2006)18F-fluorodeoxyglucose-positron emission tomography in evaluation of primary cutaneous lymphoma. Br J Dermatol. ;155(2):357-63. (if=69, ci=4.3)

8. Kumar R, Sharma P, Garg P, Karunanithi S, Naswa N, Sharma R, Thulkar S, Lata S, Malhotra A (2011). Role of (68)Ga-DOTATOC PET-CT in the diagnosis and staging of pancreatic neuroendocrine tumours. Eur Radiol.;21(11):2408-16. (if=65, ci=4.1)

9. Das CJ, Makharia G, Kumar R*, Chawla M, Goswami P, Sharma R, Malhotra A. (2007) PET-CT enteroclysis: a new technique for evaluation of inflammatory diseases of the intestine. Eur J Nucl Med Mol Imaging. ;34(12):2106-14. (*Coressponding Author) (if=46, ci=7.2)

10. B Nayak, PN Dogra, N Naswa, R Kumar*. (2013) Diuretic 18F-FDG PET/CT imaging for detection and locoregional staging of urinary bladder cancer: prospective evaluation of a novel techniqueEur J Nucl Med Mol Imaging 40 (3), 386-393 (*Coressponding Autho (if=45, ci=7.2)

398

MAHESHWARI, MONIKA (b 1975), Professor, Jawahar Lal Nehru Medical College, Ajmer


Dr. Monika Maheshwari,Professor and Unit Head in J.L.N. Medical College Ajmer has done DM (Cardiology) and Ph.D. research on ‘Echocardiographic Assessment of Right Ventricular Functions in patients with Isolated Left Ventricular Infarction’.She was the first one to demonstrate RV dysfunction in patients of Isolated LV Anterior MI,after categoric exclusion of any associated RVMI by doing Right coronary Angiography.She is a dedicated scientist in the field of Cardiology, an outstanding teacher and an acclaimed author.She has more than 200 publications in various journals and 8 chapters in medical books.Her pioneering research work has attracted considerable attention and has been awarded Dr.D.P.Basu Award of National API,Dr.D.S.Munagekar Award of National IMA, Prof. M. C. Gupta Oration of Indian Academy of Clinical Medicine, NIMS Best Research paper award of Indian Society of Geriatrics, Dr. V.G. Nadgouda Lecture Award by National RSSDI,IMA AMS Dr Satya Pal Agarwal Memorial Award by Indian Medical Association ,Gangadhar Verma Memorial Award and Jaipur Apicon Award by Rajasthan API.Her name is enlisted in Marquis Who’s Who in the World (29th edition) and in Asia /Pacific Who’s Who in the World (Vol.X).She is a Fellow of Indian College Of Physicians (FICP),Indian Society of Electrocardiology (FISE),Indian Association of Clinical Medicine (FIACM),International Medical Science Academy (FIAMS) and American College of Cardiology (FACC),Asian Pacific Society of Cardiology (FAPSC) and Euro Asian Academy of Cardiology(FEAC).

Proposer: Prof. Shyam Sundar, Seconder: Prof. Shally Awasthi


1. M Maheshwari, SR Mittal. 2004. Acute myocardial infarction complicating Snake bite. JAPI ; 52: 63-64 (if=0.28, ci=31)

2. M Maheshwari, CP Tanwar. 2012. Scorpion bite induced myocardial damage and pulmonary edema. Heart Views;13: 17-19 (if=0.61, ci=15)

3. M Maheshwari, R K Gokhroo, S K Kaushik. 2012. Isolated Non-compacted Right Ventricular myocardium. JAPI ; 60: 56-57 (if=0.71, ci=10)

4. SRMittal,MMaheshwari.2005.Electrocardiographic changes in Submassive Pulmonary Embolism. Indian Heart Journal ; 57: 80-81 (if=0.34, ci=5)

5. M Maheshwari, S Maheshwari . 2015. Clinico-Radiological Profile and Outcome of Novel H1N1-Infected Patients During 2009 to 2014 Pandemic at Tertiary Referral Hospital in Rajasthan . JAPI; 63 : 42-5 (if=0.37, ci=8)

6. SR Mittal, M Maheshwari . 2008. Absent left circumflex artery and unusual dominant right coronary artery JAPI; 56, 711 (if=0.56, ci=6)

7. M Maheshwari, SK Kaushik . 2013 . Echocardiographic assessment of left atrial volume index in elderly patients with anterior wall myocardial infarction. JAPI; 61: 310-311 (if=0.76, ci=4)

8. M Maheshwari , SR Mittal. 2004. Right-sided pneumothorax simulating anterior wall myocardial infarction. Indian Heart Journal ; 56 : 72 (if=0.40, ci=4)

9. SR Mittal, M Maheshwari .2006. Amiodarone-induced Exudative Pleural Effusion-A Case Report and Review of Literature.Indian Heart Journal ; 58 : 352 (if=0.46, ci=4)

10. M Maheshwari, SR Mittal.2013. Right ventricle myocardial performance index versus Simpson's right ventricle ejection fraction in patients with isolated left ventricle anterior myocardial infarction.Heart Views; 14 : 68 (if=0.50, ci=4)

399

MISHRA, AKHILESH CHANDRA (b 1950), Director, Interactve Research School for Health Affairs (IRSHA), BVDU, Pune


At Bharati Vidyapeeth’s Interactive Research School for Health Affairs (IRSHA): Focus-Translational Research Developed an innovative electronic surveillance system for Dengue. The project was funded (Rs 401 Lakh) by ICMR, Serum Institute of India and Bharati Vidyapeeth in PP mode, in 2017. For the first time, the disease burden of dengue was estimated based on actual surveillance data. The system will enable corporation authorities and other stakeholders to get real time data on their desk top as well as on mobile, daily updated. Under “Innovate in India for Inclusiveness (i3)”, a government of India initiative Dr Mishra received a funding support of Rs 16 Cr in 2018 from BIRAC, DBT for establishment of “National Center for Immunogenicity evaluations” for vaccines in clinical trials. This is the first facility in India that will save both time and money in clinical trials. For this purpose, a GCLP laboratory, compliant with Biosafety 2 and 3 levels, is being established at IRSHA. Funded Chikungunya, RSV vaccines development projects initiated. During tenure at National Institute of Virology, Pune: Dr Mishra contributed in path breaking investigations of Chandipura virus, causative agent of Acute Encephalitis Syndrome in central India. Under his leadership, investigations during H1N1 pandemic and H5N1 scare created a new culture of response to national health emergencies. Investigations by him in Siliguri revealed that Nipah virus, a Biosafety 4 and dangerous select agent was responsible for several fatal outbreaks. Transferred reverse genetics modified strain of H5N1 and Japanese encephalitis virus strain to industries for vaccine manufacturing.

Proposer: Prof. U.C. Chaturvedi, Seconder: Dr. G.C. Mishra


1. Malshe N, Palkar S, Kulkarni R, Lalwani S K, Mishra A C, Arankalle V A. (2019) Early disappearance of maternal anti-measles, mumps, rubella, and varicella antibodies in Indian infants. Vaccine, 37 (11); 1443-48. (if=3.24, ci=0)

2. Arankalle V A , Tiraki D , Kulkarni R , Palkar S, Malshe N, Lalwani SK , Mishra A C. (2019) Age‐stratified anti‐HAV positivity in Pune, India after two decades: Has voluntary vaccination impacted overall exposure to HAV? J Viral Hepat. 2019; 00, 1–4. https://d0i.org/10.1111/jvh.13074. (if=4.24, ci=0)

3. Mishra A C , Arankalle V A, Gadhave S A, Mahadik P H, Shrivastava S, Bhutkar M, Vaidya V M. (2018) Stratified sero-prevalence revealed overall high disease burden of dengue but suboptimal immunity in younger age groups in Pune, India. PLoS Negl Trop Dis, 12(8): e0006657. (if=4.37, ci=2)

4. Shrivastava S, Tiraki D, Diwan A, Lalwani S K, Modak M, Mishra A C, Arankalle VA. (2018) Co-circulation of all the four dengue virus serotypes and detection of a novel clade of DENV-4 (genotype I) virus in Pune, India during 2016 season. PLoS One 13(2): e0192672. (if=2.77, ci=8)

5. Chadha MS, Potdar VA, Saha S, Koul PA, Broor S, Dar L, Chawla-Sarkar M, Biswas D, Gunasekaran P, Abraham AM, Shrikhande S, Jain A, Anukumar B, Lal RB, Mishra AC.(2015) Dynamics of influenza seasonality at sub-regional levels in India and implications for vaccination timing. PLoS One. 2015 May 4;10(5):e0124122. (if=2.77, ci=38)

6. Mishra AC, Mehta M, Mourya DT, Gandhi S (2011). Crimean-Congo haemorrhagic fever in India. Lancet 23: 378. (if=53.25, ci=49)

7. Mishra AC, Chadha MS, Choudhary ML, Varsha, Potdar VA (2010) Pandemic Influenza (H1N1) 2009 Is Associated with Severe Disease in India. PLoS ONE 5(5): e10540. doi:10.1371. (if=2.77, ci=69)

8. Mishra AC, Cherian SS, Chakrabarti AK, Pawar SD, Jadhav SM, Pal B, Raut S,Koratkar S, Kode SS. (2009). A unique influenza A (H5N1) virus causing a focal poultry outbreak in 2007 in Manipur, India. Virol J. 6-26;1-11. (if=2.14, ci=17)

9. Chadha MS, Comer JA, Lowe L, Rota PA, Rollin PE, Bellini WJ, Ksiazek TG, Mishra AC. (2006). Nipah Virus-associated Encephalitis Outbreak, Siliguri, India. Emerging Infect Dis 12: 235-40. (if=7.42, ci=382)

10. Rao BL, Basu A, Wairagkar NS, Gore MM, Arankalle VA, Thakare J, Jadi, RS, Rao KA, Mishra AC. (2004). A large outbreak of acute encephalitis with high case fatality rate in children in Andhra Pradesh, India in 2003 associated with Chandipura virus. Lancet 364 (9437): 869-74. (if=53.25, ci=168)

400

MISHRA, AMIT KUMAR (b 1981), Bioscience & Bioengineering, Indian Institute of Technology Jodhpur


Dr. Amit Mishra has done significant work in the area of cellular protein quality control mechanism involved in neurodegenerative diseases. This has been achieved by understanding the quality control functions of selective multifaceted E3 ubiquitin ligases, which barricade extreme defense against misfolded proteins aggregation. His findings provide a clear and better understanding of this innovative concept that can develop new lines of potential therapeutic targets for neurodegeneration and ageing. His studies have helped in clarifying the molecular pathways of misfolded recognition strategies based on E3 Ubiquitin Ligases. Findings of Amit work enlighten precise molecular mechanism of E3 ubiquitin ligases and molecular chaperones, their involvement in cellular quality control pathways and effect overall cellular homeostasis. Amit design a different mechanism to modulates the proteasomal functions which can induced autophagy pathways and serve as anti-aggregation program of affected cellular proteostasis. Research from his lab propose that under different protein conformation conditions how E3 Ubiquitin Ligases can act as a first line of defense against proteostasis failure. Focused out come of his studies find out that promising molecular modulations of E3 Ubiquitin Ligases can regulate cellular proliferation and suppresses misfolded proteins accumulation. Dr. Amit developed innovative harnessing method of molecular protein quality control system those can inhibits aberrant protein aggregation and deregulated proliferation. Significant contributions from his group have added substantially knowledge on the progressing neurobiological approaches against multifactorial challenges in neurodegeneration. Total Citations of above work is more than 1000 H-Index: 16 I-Index: 30.

Proposer: Prof. Kanury Venkata Subba Rao, Seconder: Prof. Nihar Ranjan Jana


1. (COVER PAGE STORY) Ayeman Amanullah, Arun Upadhyay, Vibhuti Joshi, Ribhav Mishra, Nihar Ranjan Jana and Amit Mishra * (2017) Progressing Neurobiological Strategies Against Proteostasis Failure: Challenges in Neurodegeneration. DOI:10.1016/j.pneurobio.2017.08.005: Journal-Progress in Neurobiology (if=14.2 , ci=5 )

2. Deepak Chhangani, Fumito Endo, Ayeman Amanullah, Arun Upadhyay, Seiji Watanabe; Ribhav Mishra, Koji Yamanaka* and Amit Mishra* (2016) Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 aggresomes and defective in an ALS mouse model. Feb;86:16-28. doi: 10.1016/j.nbd.2015.11.017: Journal-Neurobiology of Disease (if=5.2, ci=11)

3. Arun Upadhyay, and Amit Mishra* (2018) Amyloids of multiple species: are they helpful in survival? DOI: 10.1111/brv.12399: Journal-Biological Reviews (if=11.7 , ci=1)

4. Deepak Chhangani, Nobuyuki Nukina, Masaru Kurosawa, Ayeman Amanullah, Vibhuti Joshi, Arun Upadhyay and Amit Mishra* (2014) Mahogunin ring finger 1 Suppresses Misfolded Polyglutamine Aggregation and Cytotoxicity. 2014 Sep;1842(9):1472-84. doi: 10.1016/j.bbadis.2014.04.014: Journal-BBA-Molecular Basis of Disease (if=5.4, ci=17)

5. Arun Upadhyay, Ayeman Amanullah, Deepak Chhangani, Ribhav Mishra and Amit Mishra* (2015) Selective Multifaceted E3 Ubiquitin Ligases Barricade Extreme Defense: Potential Therapeutic Targets For Neurodegeneration And Ageing.DOI: 10.1016/j.arr.2015.07.009: Journal-Ageing Research Reviews (if=8.9, ci=13)

6. Amit Mishra*, Megha Maheshwari; Deepak Chhangani, Noriko Fujimori Tonou, Fumito Endo, Ajay P Joshi, Nihar R Jana and Koji Yamanaka* (2013) E6-AP association promotes SOD1 aggresomes degradation and suppresses toxicity. 2013 Apr;34(4):1310.e11-23. doi: 10.1016/j.neurobiolaging.2012.08.016: Journal-Neurobiology of Aging (if=6.6, ci=24)

7. Ribhav Mishra, Arun Upadhyay, Vijay Kumar Prajapati (2018) and Amit Mishra* Proteasome Mediated Proteostasis: Novel Medicinal And Pharmacological Strategies For Diseases. DOI: 10.1002/med.21502: Journal-Medicinal Research Review (if=8.7, ci=2)

8. Amit Mishra, Swetha Kameshwari, Megha Maheshwari, Anand Goswami and Nihar Ranjan Jana. (2009) The ubiquitin ligase E6-AP is induced and recruited to aggresomes in response to proteasome inhibition and may be involved in the ubiquitination of HSP70 bound misfolded proteins. 2009 doi: 10.1074/jbc.M806804200: Journal of Biological Chemistry (if=4.5, ci=78)

9. Amit Mishra Priyanka Dikshit., Sudarshana Purkayastha., Jaiprakash Sharma., Nobuyuki Nukina and Nihar Ranjan Jana (2008) E6-AP promotes misfolded polyglutamine proteins for proteasomal degradation and suppresses polyglutamine protein aggregation and toxicity. Mar 21;283(12):7648-56. doi: 10.1074/jbc.M706620200 Journal of Biological Chemistry (if=4.5, ci=76)

10. UBE3A/E6-AP regulates cell proliferation by promoting proteasomal degradation of p27 A Mishra, SK Godavarthi, NR Jana 36 (1), 26-34: Neurobiology of disease (if=5.2, ci=68)

401

NATH, GOPAL (b 1961) Professor of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi


I have known Prof. Gopal Nath & followed his work for 28 years. He with his group have established for the first time the role of Salmonella Typhi in causation of Cancer Gall Bladder based on his in vitro and in vivo experiments (Scanu et al, 2015; Kumar G et al, 2012; Nath G et al, 1008; Prakash P et al, 2005; Shukla VK et al, 2000; Nath Et al, 1997). His findings emphasize the eradication of Salmonella Typhi to reduce the occurrence of CaGB. Again his bacteriophage therapy work is commendable that is applicable to deal with chronic and acute infections caused by multidrug resistant bacteria (Kishore et al, 2015). His research publications are in journal of high IF and are extensively cited (Pandey SN et al, 1999). He has consistently managed to have high end projects funded by DBT, ICMR, DST, CS&T, UP, UGC. He has been awarded Prof UC Chaturvedi oration-2017. He is also founder Secretary of “Society for Bacteriophage Research and Therapy”and Presedent of UP-UK chapter of Indian Assocaiton of Medical Microbiologists. He has got recognition of his research work in USA, UK, Nepal and Saudi Arabia. He has consistently worked on local issues-typhoid, Ca GB, Helicobacter, MDR organisms and Bacteriophage Therapy using sophisticated technology. He stands tall amongst academic fraternity and well deserves the Fellowship of NASI.

Proposer : Prof. S.C. Lakhotia, Seconder : Prof. Rajiva Raman Ten Best Publications: 1. Kishor C, Mishra RR, Saraf SK, Kumar M, Srivastav AK, Nath G. 2016; Phage therapy of Staphylococcal chronic osteomyelitis in experimental animal model. Indian J Med Res, 143 (1), 87-94 Indian Journal of Medical Research/ 2016. (if=1.446, ci=32) 2. Scanu T, Spaapen RM, Bakker JM, Pratap CB, en Wu L, Hofland I, Broeks A, Shukla VK, Kumar M, Janssen H, Song JY, Borst AN, Riele H, Holden DW, Nath G, Neefjes J. Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma. Cell Host & Microbe, 2015; 17 (6): 763–774 Cell Host & Microbe/2015. (if=12.57, ci=62) 3. SK Patel, CB Pratap, AK Verma, AK Jain, VK Dixit, G Nath. Pseudomonas fluorescens-like bacteria from the stomach: a microbiological and molecular study. World J Gastroenterol 19 (7), 1056-1067 World J Gastroenterol/2013. (if=3.80, ci=24)

4. M Gangwar, VC Verma, TD Singh, SK Singh, RK Goel, G Nath. In-vitro scolicidal activity of Mallotus philippinensis (Lam.) Muell Arg. fruit glandular hair extract against hydatid cyst Echinococcus granulosus Asian Pacific journal of tropical medicine 6 (8), 595-601. Asian Pacific journal of tropical medicine/2013. (if=0.841, ci=18)

5. Use of urine with nested PCR targeting the flagellin gene (fliC) for diagnosis of typhoid fever.G Kumar, CB Pratap, OP Mishra, K Kumar, G Nath.Journal of Clinical Microbiology 50 (6), 1964-1967. Journal of Clinical Microbiology/2012. (if=2.44, ci=16) 6. Nath G, Sigh YK, Kumar K, Gulati AK, Shukla VK, Khanna AK, Tripath SK, Jain AK, Kumar M and Singh TB. Molecular detection of chronic typhoid carriage and its association with carcinoma of the gallbladder in a typhoid endemic area. J Infect Developing Countries, 2008; 2(4): 274-279. J Infect Developing Countries, /2008. (if=1.2, ci=39) 7. Prakash P, Mishra OP, Singh AK, Gulati AK, Nath G. Evaluation of nested PCR in diagnosis of typhoid fever. J Clin Microbiol. 2005; 43: 431-432. J Clin Microbiol. /2005. (if=3.537, ci=75) 8. Shukla VK, Singh H, Pandey M, Upadhyay SK , Nath G. Carcinoma of gallbladder: Is it sequel of typhoid? Dig Dis Sci 2000; 45: 900-903. Dig Dis Sci /2000. (if=2.11, ci=133) 9. Pandeya SN, Sriram D, Nath G, DeClercq E. Synthesis, antibacterial, antifungal and antiHIV activities of Schiff and Mannich bases derived from isatin derivatives and N-[4-(4’ chlorophenyl) thiazol-2-pl]thiosemicarbaside. European J Pharma Science 1999;9:25-31;9:25-31. European J Pharma Science/1999. (if=3.463, ci=707) 10. Nath G, Singh H, Singh S, Shukla V K. Chronic Salmonella carriers and carcinoma of gallbladder. European J Canc Prev 1997; 615: 557-559. European J Canc Prev /1997. (if=2.415, ci=91)

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15635006

402

RAJAMMA, USHA (b 1962), Senior Scientist, Inter University Centre for Biomedical Research & Super Speciality Hospital (IUCBR & SSH), Kottayam


Autism, in the light of genes, behavior and neurotransmission Autism spectrum disorders (ASD) is ever increasing in its incidence globally, and in India. Dr. Usha Rajamma pioneered autism research in India and made decisive contributions to the pathophysiological understanding of this neurodevelopmental disability in terms of genes that interferes with neurotransmission causing behavioral dysfunctions. Her group has established genetic association of serotonergic system genes with autistic phenotypes in the eastern Indian cohort1,2. Further on, a sexual dimorphic effect of serotonergic system regulatory genes on ASD symptom severity3 has supported the existing dogma of male prevalence of the disorder, from evidence-based genetic studies in the Indian population4. Her group’s contribution on genetic imprinting of neurodevelopmental genes, Reelin4 and Engrailed-2 5 proved active involvement of epigenetic environment in ASD etiology. Discoveries from her laboratory generated public awareness in the Indian society on complex molecular underpinnings of autism, and the like developmental disabilities. At this juncture she moved on to South India, and initiated epidemiological surveys, and medical camps on ASD to clearly assess prevalence and at-risk factors of ASD in this population. These led to high-end research programs to investigate the neural basis of social and non-social behaviors in ASD, with active UK and US collaborations. Usha’s modest, but crucial contributions are keys to biomarker identification, that may aid in early diagnosis and drug-target discovery. 1.Jaiswal et al.(2015) Prog.Neuro-psychopharmacol.Biol.Psychiatr.,56:196-206 2. Singh et al.(2013) Prog.Neuro-psychopharmacol. Biol.Psychiatr., 45:131-43. 3.Verma et al.(2014) Prog.Neuro-psychopharmacol.Biol.Psychiatr.,50:11-20. 4.Dutta et al.(2007) Amer.J Med.Genet. Part B, Neuropsychiatr.Genet.;144B:106-12. 5.Sen et al.(2010) Genes Brain Behav.,9:248-255.

Proposer: Dr. Nahid Ali, Seconder: Dr. Pijush Kanti Das


1. Dutta S, Guhathakurta S, Sinha S, Chatterjee A, Ahmed S, Ghosh S, Gangopadhyay PK, Singh M, Usha R (2007) Reelin Gene Polymorphisms in the Indian Population: A Possible Paternal 5'UTR-CGG-Repeat-Allele Effect on Autism. Am J Med Genet Part B: Neuropsychiatr. Genet. 144B: 106-112. (if=3.016, ci=50)

2. Pandey M, Varghese M, Sindhu KM, Sreetama S, Mohanakumar KP, Usha R (2008) Mitochondrial NAD+-linked state 3 respiration and complex-I activity are compromised in the brain of 3-nitropropionic acid-induced rat model of Huntington’s disease. J. Neurochem. 104, 420-434 (if=4.609, ci=65)

3. Guhathakurta S, Singh AS, Ghosh S, Sinha S, Chatterjee A, Usha R (2009) Analysis of HTR2A gene: Association study with autism spectrum disorder in the Indian population and investigation of the gene expression in peripheral blood leucocytes. Neurochem. Int. 55: 754-759. (if=3.68, ci=27)

4. Pandey M, Borah A, Varghese M, Barman P, Mohanakumar KP, Usha R (2009) Striatal dopamine level influences oxidative stress mediated neurodegeneration in 3-nitropropionic acid-induced Huntington's disease. Neurochem Int. 55:431-437. (if=3.68, ci=23)

5. Sen B, Singh AS, Sinha S, Chatterjee A, Ahmed S, Ghosh S, Usha R (2010) Family-based studies indicate association of Engrailed 2 gene with autism in Indian population. Genes Brain Behav. 9: 248-255. (if=3.496, ci=35)

6. Singh AS, Chandra R, Guhathakurta S, Sinha S, Chatterjee A, Ahmed S, Ghosh S, Rajamma U. (2013) Genetic association and gene-gene interaction analyses suggest likely involvement of ITGB3 and TPH2 with autism spectrum disorder (ASD) in the Indian population. Prog Neuropsychopharmacol Biol Psychiatry. 2013; 45: 131-143. (if=4.185, ci=15)

7. Verma D, Chakraborti B, Karmakar A, Bandyopadhyay T, Singh AS, Sinha S, Chatterjee A, Ghosh S, Mohanakumar KP, Mukhopadhyay K, Rajamma U. (2013) Sexual dimorphic effect in the genetic association of MAOA markers with autism spectrum disorder. Prog Neuropsychopharmacol Biol Psychiatr. 50C: 11-20. (if=4.185, ci=32)

8. Jaiswal P, Guhathakurta S, Singh AS, Verma D, Pandey M, Varghese M, Sinha S, Ghosh S, Mohanakumar KP, Rajamma U. (2015) SLC6A4 markers modulate platelet 5-HT level and specific behaviors of autism: a study from an Indian population. Prog Neuropsychopharmacol Biol Psychiatry. 56: 196-206. (if=4.185, ci=13)

9. Jaiswal P, Mohanakumar KP, Rajamma U. (2015) Serotonin mediated immunoregulation and neural functions: Complicity in the aetiology of autism spectrum disorders. Neurosci. Biobehav. Rev. 55:413-431 (if=8.037, ci=20)

10. Chakraborti B, Verma D, Karmakar A, Jaiswal P, Sanyal A, Paul D, Sinha S, Singh AS, Guhathakurta S, Roychowdhury A, Panda CK, Ghosh S, Mohanakumar KP, Mukhophadhyay K, Rajamma U (2016) Genetic variants of MAOB affect serotonin level and specific behavioral attributes to increase autism spectrum disorder (ASD) susceptibility in males. Prog Neuro (if=4.185, ci=5)

403

RAMACHANDRAN, BALARAMAN (b 1948), Professor of Pharmacology, Department of Pharmacy Sumandeep Vidyapeeth Deemed University,Piparia, Waghodia, Vadodara- 391760


Prof. Balaraman, FAMS is one of the senior and eminent pharmacologists having over 40 years of experience in teaching and research. He has made significant contributions in the field of Cardiovascular Research. He did pioneering work on the mechanism of cadmium-induced hypertension He subsequently utilized this model for new drug discovery of synthetic drugs with beta blocking activity to be for the treatment of hypertension. . He then worked on herbal drugs for their significance of dyslipidemia in diabetes and hypertension, which was helpful in the evaluation of anti-hyperlipidemic herbal drugs in such metabolic disorders. During this journey of research he established the role of 5-HT on hypertension, effect of pioglitazone, LNAME and curcumin on endothelial function in diabetic rats. This work was recognized such that Prof T´aˇna Ravingerov´a, Institute for Heart Research, Centre of Excellence for Cardiovascular Research, Slovak Academy of Sciences, Slovakia collaborated with Dr Balaraman for the Effect of Hemidesmus indicus and Hibiscus Rosasinensison in Ischemia Reperfusion Injury in Isolated Rat Hearts. Recently his research collaboration with Zydus Research Centre included the role of adipocytokines in romanbant mediated insulin sensitivity in ob/ob mice and Retinol Binding Globulin in cardiovascular complications. One of his research papers entitled “Antidiabetic & antihyperlipidemic effect of neem seed kernel powder on alloxan induced diabetic rabbits” in Indian Journal of Pharmacology got the maximum citation of 300. He guided 20 students for PhD. He has published more than 125 research papers in International and National journals of repute with 2800 citationsand ‘h’-index 27.

Proposer: Prof. Ramesh K. Goyal, Seconder: Prof. L. S. Chamyal


1. Manoranjan Sharma1, Jogeswar Mohapatra1,*, Umar Malik1, Jignesh Nagar1, Abhijit Chatterjee1, R.Balaraman2 and Mukul R. Jain1 (2017), Effect of pioglitazone on metabolic features in endotoxemia model in obese diabetic db/db mice, Journal of Diabete (if=3.1.)

2. Jogeswar Mohapatra, Manoranjan Sharma, Aviseka Acharya, Gaurav Pandya, Abhijit Chatterjee, R. Balaraman and Mukul R. Jain. (2011.) Retinol Binding Protein 4: a possible role in cardiovascular complications. Br J Pharmacol. 164,1939-1948 Impact Fac (if=5.259, ci=20)

3. Vaibhav Patel, Aman Upaganlawar, Rishit Zalawadia, R. Balaraman. (2010)Cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats: A biochemical, electrocardiographic and histoarchitectural evaluation. Europea (if=2.73, ci=118)

4. Jogeshwar Mohapatra, M. Sharma, S. Singh, A. Chatterjee, P. Swain, R. Balaraman, P.R.Patel, M. R.Jain (2009),. Subtherapeutic doses of pioglitazone reduce expression of inflammatory adipokines in db/db mice, Pharmacology, 84, 203-210. Impact Fact (if=1.533, ci=13)

5. Jogeshwar Mohapatra, M. Sharma, S. Singh, G. Pandya, A. Chatterjee, R. Balaraman, P.R.Patel, M. R.Jain (2009,). Involvement of adipokines in rimonabant mediated insulin sensitivity in ob/ob mice. Journal of Pharmacy and Pharmacology, 61; 1493- (if=2.264, ci=13)

6. Vipin Dhote and Ramachandran Balaraman (2008).Anti-oxidant activity mediated neuroprotective potential of trimetazidine on focal cerebral ischaemia– reperfusion injury in rats. Clinical and Experimental Pharmacology and Physiology, 35,630-637 (if=2.37, ci=27)

7. Jayesh B Majithiya and R. Balaraman. (2006)Metformin reduces blood pressure and restores endothelial function in aorta of streptozotocin induced diabetic rats. Life Sciences, 78. 2613-2624 (if=2.72, ci=98)

8. Majithiya JB., Paramar AN., R. Balaraman. (2005) Pioglitazone,PPARγ agonist, restores endothelial function in aorta of streptozotocin-induced diabetic rats Cardiovascular Research,66(1):150-161 (if=5.6, ci=114)

9. Majithiya JB., R. Balaraman. (2005)Time dependent changes in antioxidant enzymes and vascular reactivity of aorta in streptozotocin induced diabetic rats treated with curcumin. Journal of cardiovascular pharmacology, 46 (5); 697-705 (if=2.09, ci=51)

10. Majithiya JB., Paramar AN., Trivedi CJ. R. Balaraman (2005). Effect of pioglitazone on L-NAME induced hypertension in STZ-diabetic rats. Vascular pharmacology. 43; 260-266. (if=3.6, ci=33)

404

RANA, SURINDER SINGH (b 1975), Professor, Postgraduate Institute of Medical Education and Research, Chandigarh


Dr Surinder Singh Rana is Professor of Gastroenterology at Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh. His areas of research are pancreatic disorders and therapeutic endoscopy and endoscopic ultrasound (EUS). He has worked on various innovative endoscopic and endoscopic ultrasound methods for treating various pancreatic diseases with minimally invasive methods. To his credit, there are several first time clinical and imaging features of various gastrointestinal disorders. He has published 335 papers of high scientific standard in various journals. He has been awarded various awards and orations including Young Investigator Award by Indian Society of Gastroenterology (ISG), Young Clinician Award by World Gastroenterology Organization, Don Wilson Award (Crystal award) of the American Society of Gastrointestinal Endoscopy, Postgraduate grants by European Society of Gastrointestinal Endoscopy (ESGE), “Shakuntala Amir Chand Award 2006” by Indian Council of Medical Research (ICMR) for significant contribution in biomedical research, “ISG Alkem Omprakash Memorial Award” by the Indian Society of Gastroenterology for significant contribution in research, Young Scientist Medal by Indian National Science Academy, NASI- Scopus Elsevier Young Scientist Award, ISG Zydus Alidac Oration 2015 by Indian Society of Gastroenterology, and ISG-J Mitra Memorial Endoscopy Award (2012) for outstanding contribution in the field of gastrointestinal endoscopy. He has been awarded the fellowship of American Society of Gastrointestinal Endoscopy (ASGE), Society of Gastrointestinal Endoscopy of India (FSGEI) and Association of Interventional GI Endoscopy of India (FAIGE).

Proposer: Prof. B.C. Das, Seconder: Prof. Arunaloke Chakrabarti


1. Rana SS, Sharma V, Sharma RK, Chhabra P, Gupta R, Bhasin DK. (2015) Clinical significance of presence and extent of extrapancreatic necrosis in acute pancreatitis. J Gastroenterol Hepatol.30 (4):794-8. (if=3.322, ci=10)

2. Rana SS, Bhasin DK, Sharma RK, Kathiresan J, Gupta R. (2014) Do the morphological features of walled off pancreatic necrosis on endoscopic ultrasound determine the outcome of endoscopic transmural drainage? Endosc Ultrasound.; 3(2):118-22. (if=2.794, ci=27)

3. Babu RY, Gupta R, Kang M, Bhasin DK, Rana SS, Singh R. (2013) Predictors of surgery in patients with severe acute pancreatitis managed by the step-up approach. Ann Surg.; 257(4):737-50. (if=8.569, ci=103)

4. Rana SS, Bhasin DK, Rao C, Gupta R, Singh K. (2013) Non-fluoroscopic endoscopic ultrasound-guided transmural drainage of symptomatic non-bulging walled-off pancreatic necrosis. Dig Endosc. 25(1):47-52. (if=2.715, ci=38)

5. Santhosh S, Mittal BR, Bhasin D, Srinivasan R, Rana S, Das A, Nada R, Bhattacharya A, Gupta R, Kapoor R. Role of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography in the characterization of pancreatic masses: experience from t (if=3.322, ci=33)

6. Rana SS, Bhasin DK, Chandail VS, Gupta R, Nada R, Kang M, Nagi B, Singh R, Singh K. (2011) Endoscopic balloon dilatation without fluoroscopy for treating gastric outlet obstruction because of benign etiologies. Surg Endosc. ;25(5):1579-84 (if=3.540, ci=25)

7. Rana SS, Bhasin DK, Srinivasan R, Singh K. (2011) Endoscopic ultrasound-guided fine needle aspiration of peritoneal nodules in patients with ascites of unknown cause. Endoscopy. ;43(11):1010-3. (if=5.634, ci=17)

8. Bhasin DK, Rana SS, Nanda M, Chandail VS, Masoodi I, Kang M, Kalra N, Sinha SK, Nagi B, Singh K. (2010) Endoscopic management of pancreatic pseudocysts at atypical locations. Surg Endosc. 24(5):1085-91 (if=3.540, ci=32)

9. Rana SS, Bhasin DK, Nanda M, Singh K. (2007) Parasitic infestations of the biliary tract. Curr Gastroenterol Rep.9(2):156-64. (if=1.000, ci=74)

10. Bhasin DK, Rana SS, Udawat HP, Thapa BR, Sinha SK, Nagi B. (2006) Management of multiple and large pancreatic pseudocysts by endoscopic transpapillary nasopancreatic drainage alone. Am J Gastroenterol. 101(8):1780-6 (if=10.383, ci=40)

405

SAGAR, RAJESH (b 1964), Professor, Department of Psychiatry, All India Institute of Medical Sciences (AIIMS), New Delhi.


Dr Rajesh Sagar, as clinician developed the services for Child and Adolescent Psychiatry and started the separate inpatient services in his institution. He has significant experience as a policy expert and has expertise in conducting community research related to mental health at the national and international level. In the capacity as Secretary, Central Mental Health Authority and honorary advisor on mental health for DGHS, MoHFW, Govt. of India, he has been involved in the NMHP and has also worked to strengthen Psychiatry in undergraduate medical education. He involved with development of national mental health policy, the new mental health care bill, insurance cover for mentally ill persons, training program for primary care doctors etc. He is excellent clinician, academician and researcher par excellence. He has successfully accomplished 98 funded research projects as investigator on varied aspects of the mental health. His work has been published more than 300 articles in peer-reviewed national and int.journals/books/chapters. He has also been a guide/co-guide of 96 MD/MS/DM/MSc thesis work in addition to 30 PhD students. He has made important contribution at int. level such as coordinator and PI of pioneering work in India on World Mental Health Survey, supported by the WHO (HQ) and Harvard Medical School, USA and may more international projects. He also conducted the Audit of Mental Health services in Maldives, awarded International Exchange Program by Royal Society of Edinburgh for the Robert Gordon University, Aberdeen UK. He also has been an Honorary Professor by department of Psychiatry, University of Melbourne, Australia.

Proposer: Prof. N.R. Jagannathan, Seconder: Prof. Ravinder Goswami


1. Merikangas KR, Jin R, He JP, Kessler RC, Lee S, Sampson NA, Sagar R, .. (2011). Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative. Arch Gen Psychiatry. 68(3):241-51. (if=15.307, ci=1089)

2. Kessler RC, McLaughlin KA, Green JG …Sagar R… (2010). Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys. Br J Psychiatry. 197:378-85 (if=7.06, ci=753)

3. Nock MK, Hwang I, Sampson N …Sagar R … (2009). Cross-national analysis of the associations among mental disorders and suicidal behavior: findings from the WHO World Mental Health Surveys. PLoS Med. 6(8):e1000123 (if=16.269, ci=477)

4. Kessler RC, Green JG, Gruber MJ …Sagar R, (2010). Screening for serious mental illness in the general population with the K6 screening scale: results from the WHO World Mental Health (WMH) survey initiative. Int J Methods Psychiatr Res.19 Suppl (if=3.759, ci=400)

5. Borges G, Nock MN, Abad JMH …Sagar R … (2010). Twelve-Month Prevalence of and Risk Factors for Suicide Attempts in the World Health Organization World Mental Health Surveys, J Clin Psychiatry. 71(12), 1617 (if=5.812, ci=325)

6. Kessler RC, Ormel J, Petukhova M…. Sagar R…. et al. (2011). Development of lifetime comorbidity in the World Health Organization world mental health surveys. Arch Gen Psychiatry. 68(1):90-100 (if=15.307, ci=273)

7. Sagar R, Pattanayak RD, Chandrasekaran R, et al.(2017) Twelve-month prevalence and treatment gap for common mental disorders: Findings from a large-scale epidemiological survey in India. Indian J Psychiatry 2017;59: 46-55 (if=0.81, ci=7)

8. Wang H, Naghavi M, Allen C... Sagar R…et al (2016). Global, regional and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015 (if=44.002, ci=325)

9. Stein DJ, Chiu WT, Hwang I…. Sagar R…. et al. (2010). Cross-national analysis of the associations between traumatic events and suicidal behavior: findings fromthe WHO World Mental Health Surveys. PLoS One. 13;5(5):e10574 (if=16.269, ci=183)

10. Alonso J., Petukhova M., Vilagut G…. Sagar R…. et al. (2011). Days out of role due to common physical and mental conditions: results from the WHO World Mental Health surveys. Molecular Psychiatry, 16(12), 1234–1246 (if=13.204, ci=180)

406

SAXENA, SANDEEP (b 1965), Senior Professor and Chief of Retina, Department of Ophthalmology, King George's Medical University, Lucknow


Prof. Sandeep Saxena has contributed scientifically over past twenty five years.His pioneering translational research, in Retinal Vascular Diseases (Diabetic Retinopathy and Eales’ disease), provided unique insight into pathogenesis, unravelled new approaches for drug therapies and defined classification systems for disease monitoring and planning management. In diabetic retinopathy, he discovered external limiting membrane (ELM) as part of retinal barrier. He discovered the mechanism of retinal photoreceptor ellipsoid zone disruption and related vision loss, using spectral-domain optical coherence tomography (SD-OCT). Disruption of ELM led to photoreceptor microstructural changes. He discovered central subfield and cube average thickness and resistive index of ophthalmic artery as bioimaging biomarkers and VEGF, ICAM-1, NεCML and antimyeloperoxidase antibody as biomolecular biomarkers for retinal dysfunction and disease progression (Molecular Vision-2013; Diabetes Complications-2016; International J Retina Vitreous-2015, Retina-2017, Biomarker-2017). His published three SD-OCT-based classification systems for disease monitoring and planning management strategies are followed worldwide (Mol Vis-2013, Clinical Experimental Ophthalmology-2015, Retina-2017). In Eales’ disease, he discovered autoimmunity and cytokine dysfunction in pathogenesis. He published a novel grading system incorporating disease severity and management strategies, introduced novel low-cost medical therapy and paved way for newer immunotherapy approaches (Pathobiology-1999, 2011; Ocular Inflammation-Immunology-2009, European Ophthalmology-2004, 2005). Based on his exceptional contribution, he delivered 'Invited Ophthalmology Special Lectures' at Oxford University and Harvard University.He designed an innovative instrument ‘Saxena Retinal Grid-520 & 428’ (Ocular Instruments-USA) for measuring retinal lesions.

Proposer: Dr. Asha Mathur, Seconder: Dr. Prahlad K. Seth


1. Saxena S, Rajasingh J, Biswas S, Kumar D, Shinohara T, Singh VK. 1999. Cellular immune response to Retinal S-antigen and Interphotoreceptor Retinoid Binding Protein fragments in Eales’ disease patients. Pathobiology 67:37-44. Switzerland. (if=2.48, ci=40)

2. Rai G, Saxena S, Kumar H, Singh VK. 2001. Human Retinal S-antigen: T cell epitope mapping in posterior uveitis patients. Experimental and Molecular Pathology 70:140-145. U.S.A. (if=2.98, ci=30)

3. Lincoff H, Madjarov B, Lincoff N, Movshovich A, Saxena S, Coleman DJ, et al. 2003. Pathogenesis of the vitreous cloud emanating from subretinal hemorrhage. Archives of Ophthalmology 121:91-96. U.S.A. (if=4.34, ci=25)

4. Saxena S, D Kumar D. 2004. A new staging system for idiopathic retinal periphlebitis. European Journal of Ophthalmology 14 (3), 236-239 (if=1.01, ci=39)

5. Tripathi P, Saxena S, Yadav VS, Naik S, Singh VK. 2004. Human S-antigen: peptide determinant recognition in uveitis patients. Experimental and Molecular Pathology 76:122-128. U.S.A. (if=2.98, ci=14)

6. Lincoff H, Stopa M, Kreissig I, Madjarov B, Saxena S, Sarup V, Brodie S. 2006. Cutting the encircling band. Retina 26:650-654. U.S.A.(if=3.24, ci=56)

7. Saxena S, Khanna VK, Pant AB, Meyer CH, VK Singh. 2011. Elevated tumor necrosis factor in serum is associated with increased retinal ischemia in proliferative Eales’ disease. Pathobiology 78: 261-265. Switzerland (if=2.48, ci=10)

8. Jain A, Saxena S, Khanna VK, Shukla R, and Meyer CH. 2013. Status of serum VEGF and ICAM-1 and its association with external limiting membrane and IS-OS junction disruption in type 2 diabetes mellitus. Molecular Vision 19:1760-68. U.S.A. (if=2.48, ci=38)

9. Sharma S, Saxena S, Srivastav K, Shukla RK, Mishra N, Meyer CH, et al. 2015. Nitric oxide and oxidative stress is associated with severity of diabetic retinopathy and retinal structural alterations. Clinical & Experimental Ophthalmology 43: 429-436, (if=1.88, ci=27)

10. Mishra N, Saxena S, Shukla RK, Singh V, Meyer CH, Kruzliak P, et al. 2016. Association of serum N ε-Carboxy methyl lysine with severity of diabetic retinopathy. Journal of Diabetes and its Complications 30: 511-517. Europe (if=3.01, ci=10)

407

SENGUPTA, SHARMILA (b 1959), Professor, National Institute of Biomedical Genomics, Kalyani, West Bengal


The nominee's recent studies have provided seminal insights on human-HPV interaction and molecular distinctiveness of cervical cancer (CaCx) caused by HPV in its episomal form: • HPV16 in episomal form can cause cervical cancer (CaCx), in contrast to the traditional wisdom that CaCx is caused only when HPV16 is integrated in the host DNA. • Blocking of E2 binding to its cognate binding sites within the viral enhancer-promoter, due to nucleotide variations (Gynecologic Oncology 2006) or CpG methylations (Virology 2006), supports expression of HPV16 oncoproteins, E6 and E7, in episomal CaCx subtypes • Physical interaction between high levels of E7 and lncRNA HOTAIR, in a small subset of CaCx patients, causes abrogation in PRC2-LSD1 complex recruitment by HOTAIR, with gain and loss of chromatin activating and suppressing histone marks, respectively, at the metastatic gene promoters that enhanced expression of such genes (Scientific Reports 2015; and Oncotarget 2017). • Abrogation of HOTAIR secondary structure and gain of miR-22 binding site within HOTAIR encoding gene caused by a genetic variation, downregulated its expression, concomitant with E7 dependent miR-22 upregulation (Cellular Oncology 2016). • CaCx-associated HLA class I alleles exhibit genomic variation and consequent differential downregulation in HLA-A, HLA-B, and HLA-C expression in CaCx subtypes harbouring episomal and integrated HPV16 (Int J Cancer, 2017). • Downregulation of miR-181c expression correlates significantly with overexpression of its target, CKS1B gene, among episomal CaCx subtypes, paving the way for treatment by drugging CKS1B with its inhibitor “Fluoxetine”. (Cell Death and Discovery, 2019).

Proposer: Prof. Partha P. Majumder, Seconder: Dr. Susanta Roychoudhury


1. Bhattacharya P, Duttagupta C and Sengupta S (2002). Proline homozygosity in codon 72 of p53: a risk genotype for human papillomavirus related cervical cancer in Indian women. Cancer Letters, 188, 207-211.[ (if=6.375, ci=51)

2. Bhattacharya P and Sengupta S (2005). Lack of evidence that proline homozygosity at codon 72 of p53 and rare arginine allele at codon 31 of p21 jointly mediate cervical cancer susceptibility among Indian women. Gynecologic Oncology 99, 176-182. (if=4.54, ci=29)

3. Bhattacharjee B and Sengupta S. (2006). HPV16 E2 gene disruption and polymorphisms of E2 and LCR: some significant associations with cervical cancer in Indian women. Gynecologic Oncology 100, 372-378. (if=4.54, ci=44)

4. Bhattacharjee B and Sengupta S (2006). CpG methylation of HPV 16 LCR at E2 binding site proximal to P97 is associated with cervical cancer in presence of intact E2. Virology 354, 280-285. (if=3.374, ci=112)

5. Das D, Bhattacharjee B, Sen S, Mukhopadhyay I and Sengupta S (2010). Association of viral load with HPV16 positive cervical cancer pathogenesis: causal relevance in isolates harbouring intact viral E2 gene. Virology 402, 197-202. (if=3.374, ci=28)

6. Sharma S, Mandal P, Sadhukhan T, Roy Chowdhury R, Mondal N.R., Chakravarty B, Chatterjee T, Roy S and Sengupta S (2015). Bridging Links between Long Noncoding RNA HOTAIR and HPV Oncoprotein E7 in Cervical Cancer Pathogenesis. Scientific Reports 5:11724/DOI: 10.1038/srep11724. (if=4.609, ci=49)

7. Saha Sharma, S., Roy Chowdhury, R., Mondal, N.R., Chakravarty, B., Chatterjee, T., Roy, S., and Sengupta, S. (2016). Identification of genetic variation in the lncRNA HOTAIR associated with HPV16-related cervical cancer pathogenesis. Cellular Oncology 39, 559-572.(if=4.761, ci=14)

8. Das Ghosh, D., Mukhopadhyay, I., Bhattacharya, A., Roy Chowdhury, R., Mandal, N.R., Roy, S.,and Sengupta, S (2017). Impact of genetic variations and transcriptional alterations of HLA class I genes on cervical cancer pathogenesis. International Journal of Cancer 140 (11), 2498-2508. (if=7.36, ci= 9)

9. Saha Sharma, S., Roy Chowdhury, R., Mandal, N.R., Roy, S.,and Sengupta, S (2017). Expression signatures of HOX cluster genes in cervical cancer pathogenesis: Impact of human papillomavirus type 16 oncoprotein E7. Oncotarget 8, 36591-36602. (if=5.168, ci=5)

10. Mandal P, Sharma Saha S, Sen S, Bhattacharya A, Bhattacharyya N.P., Bucha S, Sinha M, Roy Chowdhury R, Mandal N.R., Chakravarty B, Chatterjee T, Roy S, Chatterjee A and Sengupta S (2019). Cervical cancer subtypes harbouring integrated and/or episomal HPV16 portray distinct molecular phenotypes based on transcriptome profiling of mRN (if=Not available, ci=just published)

408

SHARMA, JAI BHAGWAN (b 1960) Professor, Dept.of Obstetrics & Gynaecology, All India Institute of Medical Sciences, New Delhi-110029


Prof. J. B. Sharma has made significant contributionsin the field of Obstetrics and Gynaecology. He has completed two research projects entitled “CORONIS International study of caesarean section surgical techniques: a randomised factorial trial” from 2004-2007and “CORONIS International study of caesarean section surgical techniques: the follow-up study” from 2007-2014 with NPEU University of Oxford with two publications in The Lancet. He has about 300 publications with 150 being in Pubmed indexed journals including 20 on various aspects of female genital tuberculosis(FGTB), including a land mark RCT published in European Journal of Obstetrics and Gynaecology which has proven the efficacy of 6 months antituberculosis therapy female genital tuberculosis. He has developed new laparoscopic sign in FGTB like Sharma’s Blue Python Sign, Sharma’s Hanging Gallbladder Sign, Sharma’s Ascending Colonic Adhesion, Sharma’s Kissing Fallopian tube sign and Sharma’s Dried Tree Branch Fallopian Tubes Sign. He has 30 years (20 years as faculty) experience in the obstetrics and gynaecology including 4 years in various UK hospitals. He is a popular under graduate and postgraduate teacher and examiner for MRCOG, MD, DNB, DGO and MBBS examinations. He has written and edited 5 books is editor of 2 journals and is on the editorial board of 4 other journals & reviewers for many International and national journals. He has organized many conferences and CMEs and has delivered lectures in various international and national conferences. Dr J B Sharma was awarded Dr B C Roy Award for Research by Hon'ble President of India for the year 2015.

Proposer : Prof. S.K. Sharma, Seconder : Prof. Sanjeev Sinha Ten Best Publications: 1. Abalos E, Addo V, Brocklehurst P, El Sheikh M, Farrell B, Gray S, Hardy P, Juszczak E, Mathews JE, NazMasood S, Oyarzun E, Oyieke J, Sharma JB, Spark P. Caesarean section surgical techniques: 3 year follow-up of the CORONIS fractional, factorial, unmasked, randomised controlled trial. CORONIS collaborative group, Lancet. 2016 Jul 2; 388 (10039):62-72. (if= 44.00, ci=03) 2. Abalos E, Addo V, Brocklehurst P, El Sheikh M, Farrell B, Gray S, Hardy P, Juszczak E, Mathews JE, Masood SN, Oyarzun E, Oyiek J, Sharma JB, Spark P. Caesarean section surgical techniques (CORONIS): a fractional, unmarsked, randomized controlled trial. CORONIS Collaborative Group Lancet. 2013 Jul 20; 382(9888):324-48. (if= 44.00, ci=06) 3. Sharma JB, Jain S, Mallika V, Singh T, Kumar A, Arora R, Murthy NS. A prospective, partially randomized study of pregnancy outcomes and hematologic responses to oral and intramuscular iron treatment in moderately anemic pregnant women. Am J ClinNutr. 2004 Jan; 79(1):116-22. (if=6.70, ci=16) 4. Sharma JB, Singh N, Dharmendra S, Singh UB, P V, Kumar S, Roy KK, Hari S, Iyer V, Sharma SK. Six months versus nine months anti-tuberculous therapy for female genital tuberculosis: a randomized controlled trial. Eur J Obstet Gynecol Reprod Biol. 2016 Jun 28; 203:264-273. (if= 1.66, ci= 00) 5. Sharma JB, Kumar A, Kumar A, Malhotra M, Arora R, Prasad S, Batra S. Effect of lycopene on pre-eclampsia and intra -terine growth retardation in primigravidas. Int J Gynecol Obstet. 2003; 81(3):257-62. (if= 1.67, ci=07) 6. Sharma JB, Roy KK, Pushparaj M, Kumar S. Hysteroscopic findings in women with primary and secondary infertility due to genital tuberculosis. Int J Gynecol Obstet. 2009; 104(1):49-52. (if= 1.67, ci=13) 7. Sharma JB, Bumma SD, Saxena R, Kumar S, Roy KK, Singh N, Vanamail P. Cross sectional, comparative study of serum erythropoietin, transferrin receptor, ferritin levels and other hematological indices in normal pregnancies and iron deficiency anemia during pregnancy. Eur J Obstet Gynecol Reprod Biol. 2016 May 20; 203:99-103. (if= 1.66, ci=00) 8. Sharma JB, Roy KK, Pushparaj M, Kumar S, Malhotra N, Mittal S. Laparoscopic findings in female genital tuberculosis. Arch Gynecol Obstet. 2008 Oct; 278(4):359-64. (if= 1.68, ci=26) 9. Sharma JB, Karmakar D, Hari S, Singh N, Singh SP, Kumar S, Roy KK. Magnetic resonance imaging findings among women with tubercular tubo-ovarian masses. Int J Gynecol Obstet. 2011;113:76-80. (if= 1.67, ci=04) 10. Sharma JB, Karmakar D, Kumar R, Shamim SA, Kumar S, Singh N, Roy KK, Reddy RM. Comparison of PET/CT with other imaging modalities in women with genital tuberculosis. Int J Gynecol Obstet. 2012;118:123-8. (if= 1.67, ci= 02)

409

SRIVASTAVA, DEEP NARAYAN (b 1958), Professor, Department of Radiodiagnosis, All India Institute of Medical Sciences (AIIMS), New Delhi - 110029.


He has established some advanced techniques in Interventional Radiology (IR) & Magnetic resonance imaging (MRI). He has established various IR techniques in India, which are minimally invasive life saving procedures, now viable alternatives to traditional invasive therapies and can be performed in the outpatient settings and also as a life saving or palliative in cancer care or as a standard treatment method. In IR he started angiographic radioembolization in liver cancer for the first time in India under a multicentre trial funded by International Atomic Energy Agency (IAEA), established round the clock facility of life saving minimally invasive IR procedures at AIIMS for the management of tuberculosis and lung cancer patients, vertebroplasty, to treat osteoporosis common in elderly population making them walking independently, Uterine artery embolization a life saving procedure in post delivery. For training of these IR procedures he developed a low cost indigenous phantom, made from locally available materials for training. He has also developed few indigenous (Homemade) techniques /materials which are useful for life saving procedures with no cost to patient. In MRI he started doing MR arthrography and established cartilage and bone marrow imaging, MR guided biopsy techniques etc. He was member of expert committee of standard treatment guidelines (STGs-2010), Ministry of Health & Family Welfare, New Delhi. He has 144 published papers including 23 chapters in different textbooks and edited one textbook. He is current secretary of National academy of Medical Sciences (India).

Proposer: Prof. N.R. Jagannnathan, Seconder: Prof. Ravinder Goswami


1. Gastrointestinal hemorrhage in hepatocellular carcinoma: management with transhepatic arterioembolization. DN Srivastava, D Gandhi, PK Julka et al. Abd Imaging, 2000, 25(4): 380-384. (if=1.9, ci=24)

2. Transcatheter arterial embolization in the treatment of symptomatic cavernous hemangiomas of the liver: a prospective study. DN Srivastava, D Gandhi, A Seith et al. Abd Imaging, 2001, 26(5): 510-4. (if=1.9, ci=98)

3. Colour Doppler flow imaging of focal hepatic lesions. DN Srivastava, A Mahajan, M Berry et al. Australasian Radiology, 2000, 44(3): 285-289. (if=NA, ci=15)

4. Gastric volvulus: acute and chronic presentation. G Shivananad, S Seema, DN Srivastava, GK Pandey et al. Clinical Imaging, 2003, 27: 265-268. (if=0.6, ci=71)

5. Transcatheter arterial embolization in the management of hemobilia. DN Srivastava, S Sharma, S Pal et al. Abd Imaging, 2006, 31(4): 439-448. (if=1.9, ci=64)

6. Inoperable Hepatocellular Carcinoma: Transarterial 188Re HDD – labelled iodized oil for treatment – Prospective Multicenter Clinical Trials. A Kumar, DN Srivastava, TTM Chau et al. Radiology, 2007, 243(2): 509 – 519. (if=6.2, ci=60)

7. Radiofrequency ablation of liver metastases from breast cancer: results in 14 patients. G Gunabushanam, S Sharma, S Thulkar, DN Srivastava, GK Rath et al. J Vasc Interv Radiol 2007, 18: 67 – 92. (if=2.1, ci=43)

8. Radiological evaluation of covered self-expandable metallic stents used for palliation in patients with malignant esophageal strictures. Z Neyaz, DN Srivastava, S Thulkar, S Bandhu, S Gamangatti et al. Acta Radiologica, 2007, 2: 156 – 1 (if=1.3, ci=21)

9. Imaging the inferior vena cava: a road less traveled. H Kandpal, R Sharma, S Gamangatti, DN Srivastava and S Vashisht. Radiographics 2008; 669 – 689. (if=2.6, ci=105)

10. Clinical impact of multidetector row computed tomography before bronchial artery embolization in patients with hemoptysis: a prospective study. M Gupta, DN Srivastava, A Seith, S Sharma et al. Can Assoc Radiol J, 2013 64(1): 61-73. (if=0.5, ci=12)

410

BANERJEE, MONISHA (b 1965) Professor, University of Lucknow, Lucknow

Member of the NASI: No

(YON 2016, Medical & Forensic Sciences)

Dr. Monisha Banerjee, Professor is actively involved in genetic studies of complex diseases such as Type 2 Diabetes Mellitus, Cervical Cancer and Pulmonary Diseases for the last 10 years in collaboration with KGMU, Balrampur Hostpital, SGPGIMS and Lucknow Cancer Hospital. She has completed 08 national projects successfully since 2008. She has identified genetic variants in candidate genes and their association with type 2 diabetes (T2DM), cervical cancer (CaCx) and COPD leading to risk genotypes/haplotypes in North Indian population. Her work has led to the identification of several risk alleles associated with individual susceptibility to T2DM and CaCx which will greatly help in designing pharmacogenetics-guided preventive and therapeutic measures (IndianJMedSci, 2008,62:259-266;IndianJMedSci,2009,63:187-194;IntJDiabMellitus,2010,2:179-183;ClinChimActa,2012,413:1163–170; Diab TechTherap, 2013,15(8):680-687;EurJObsGynecolReprodBiol,2014,176:68-74;FreeRadRes, 2015,49:17-24;GenetTestMolBiom,2015,19:144- 149;PLoSONE,2015,10(11):e0142501;WJDiab,2016, 7:302-315;CurrDiabRev,2018,14:307-319;BrJBiomedSci,2018,75:169-174;BrJBiomedSci,2019, doi.org /10. 1080/ 09674845.2019.1595869). Her group has contributed in validating several natural and synthetic compounds for their anticancerous activity. She has presently expanded her research activities in the field of nanotechnology (synthesizing nanoparticles and testing them against cancer cell lines) with the aim of searching for a compound against cervical cancer (JMolStr,2019,1180:733-740;JMolStr,2018,1166:54-62;JMolStr,2017,1141:678-686;Cell Prolif,2015,48:443-454). Another significant contribution is establishing the method for isolation of cell free fetal DNA (cffDNA) from maternal plasma for prediction of pregnancy related complications like preeclampsia and gestational diabetes (AnnalsBiolRes,2011,2:155-164;ISRN Genetics,2013(2013),Article ID 961293). She has contributed to human health by developing manpower for teaching and research. She has guided 15 Ph.D scholars till date and has trained >25 teachers and students in cell and molecular biology techniques. Her scientific contribution also include development of diagnostic methods for genetic disorders during her postdoc tenure at SGPGIMS (AmJMedGenet,2001,101:198-202;IndianJMedRes,2001,113:19-25;EurUrol,2002,41:318-322; IntJMolMed,2002,9:91-94;ExpMol Med,2003, 35:113-117; IndianJHumGenet,2003,9: 41-51; Perinatology,2004,6:221-230,IndianJ Ped,2009,76:147-149).

Proposer : Dr. P. Kalpana P Murthy, Seconder : Dr. Shailja Bhattacharya Ten Best Publications: 1. Kumar R, Mukherjee M, Sidhu H, Bhandari M, Mittal RD (2002). Role of Oxalobacter formigenes in calcium oxalate stone disease: A study from North India. European Urology, 41: 318-322. (if=17.581, ci= 104) 2. Bid HK, Konwar R, Saxena M, Agarwal CG, Banerjee M (2009). Vitamin D receptor (VDR) gene (Fok I, Taq I, BsmI) polymorphisms related with type-II diabetes mellitus in North Indian population. Indian Journal of Medical Science, 63(5): 187-194. (if=1.532, ci= 118) 3. Gautam S and Banerjee M (2011). The Macrophage Ox-LDL receptor, CD36 and its association with type II diabetes mellitus. Molecular Genetics and Metabolism, 102(4): 389-398. (if= 3.774, ci= 46) 4. Banerjee M and Saxena M (2012). Interleukin-1 (IL-1) family of cytokines: Role in type 2 diabetes. Clinica Chemica Acta, 413: 1163–1170. (if= 2.926, ci= 138) 5. Tabassum R, Chauhan G, Dwivedi OP…….Saxena M, Banerjee M…………Basu A, Scaria V, McCarthy M, DIAGRAM, INDICO, Venkatesan R, Mohan V, Tandon N, Bharadwaj D (2013). Genome wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21. Diabetes, 62: 977-986. (if= 7.273, ci= 120) 6. Banerjee M and Vats P (2014). Reactive metabolites and antioxidant gene olymorphisms in type 2 diabetes mellitus. Redox Biology, 2: 170-177. (if= 7.126, ci= 98) 7. Abbas M, Srivastava K, Imran M, Banerjee M (2014). Association of CYP1A1 gene variants rs4646903 (T>C) and rs1048943 (A>G) with cervical cancer in North Indian population. European Journal of Obstetrics & Gynecology and Reproductive Biology, 176: 68-74. (if= 1.809, ci= 23) 8. Vats P, Sagar N, Singh TP, Banerjee M (2015). Association of superoxide dismutases (SOD1 and SOD2) and Glutathione peroxidase 1 (GPx1) gene polymorphisms with Type 2 diabetes mellitus. Free Radical Research, 49(1): 17–24. (if= 3.038, ci= 41) 9. Saxena M, Srivastava N, Banerjee M (2018). Cytokine gene variants as predictors of type 2 diabetes mellitus. Current Diabetes Review 14(3):307-319. (if= 3.621, ci= 04) 10. Abbas M, Kushwaha VS, Srivastava K, Raza ST, Banerjee M (2018). Impact of GSTM1, GSTT1 and GSTP1 genes polymorphisms on clinical toxicities and response to concomitant chemoradiotherapy in cervical cancer. British J Biomedical Science Oct;75(4):169-174. (If= 1.969, Ci= 03)

411

BARAL, RATHINDRANATH (b 1962) Senior Scientific Officer in Assistant Director Grade, Chittaranjan

National Cancer Institute, Kolkata, India


Nominee is dedicated in the research on ‘Cancer Immunology and Immunotherapy’. His research group is trying improve the dysregulated immunity in tumor host by immunomodulation. The group described a novel glycoprotein from neem leaf, designated as ‘Neem Leaf Glycoprotein’. NLGP restricts murine sarcoma, melanoma and carcinoma by systemic immunomodulation in CD8+ T cell dependent manner. Detail immunobiochemical mechanism are being attempted to elucidate. NLGP prevents aberrant angiogenesis and metastasis in cancer and possess unique tumor microenvironment normalizing property. Present focus of the lab includes, characterization of various tumor microenvironmental events (e.g., stromal/stem cell biology, cellular behavior in tumor hypoxia etc.) and structural determination of NLGP. This molecule is in process of clinical translation. In addition, immunomodulation by interferon alpha 2b was also investigated with special effort to the treatment of renal cell carcinoma patients.

Proposer: Prof. Syamal Roy, Seconder: Dr. Uday Bandopadhyay


1. Ghosh S, Sarkar M, Ghosh T, Guha I, Bhuniya A, Saha A, Dasgupta S, Barik S, Bose A, Baral R*, Neem leaf glycoprotein generates superior tumor specific central memory CD8+ T cells than cyclophosphamide that averts post-surgery solid sarcoma recurrence, Vaccine (in press) (if=3.41; ci= yet to cite) 2. Roy S, Lu K, Nayak MK, Bhuniya A, Ghosh T, Kundu S, Ghosh S, Baral R, Dasgupta PS, Basu S. Activation of D2 dopamine receptors in CD133+ve cancer stem cells in non-small cell lung carcinoma inhibits proliferation, clonogenic ability and invasiveness of these cells (2016) J Biol Chem 292, 435-445. (if=4.26; ci= yet to be cited) 3. Ghosh T, Barik S, Bhuniya A, Dhar J, Ghosh S, Sarkar M, Guha I, Sarkar K, Chakrabarti P, Saha B, Storkus WJ, Baral R*, Bose A*, Tumor-associated mesenchymal stem cells inhibit naïve T cell expansion by blocking cysteine export from dendritic cells (2016) Int J Cancer, 139, 2068-81. (if=5.50; ci= yet to be cited) 4. Bose A, Barik S, Banerjee S, Ghosh T, Mallick A, Bhattacharya Majumdar S, Goswami KK, Bhuniya A, Banerjee S, Baral R, Storkus WJ, Dasgupta PS, Majumdar S, Tumor-derived vascular pericytes anergize T helper cells (2013) J Immunol 191, 971-981. (if=5.59; ci= 13) 5. Mallick A, Barik S, Goswami KK, Banerjee S, Ghosh S, Sarkar K, Bose A, Baral R*, Neem leaf glycoprotein activates CD8+ T cells to promote therapeutic anti-tumor immunity inhibiting the growth of mouse sarcoma (2013) PLoS One, 8, e47434. (if=4.09; ci= 21) 6. Bose A, Chakraborty K, Sarkar K, Chakraborty T, Goswami S, Pal S, Baral R*, Neem leaf glycoprotein induces perforin mediated tumor cell killing by T and NK cells through differential regulation of IFNg signaling (2009) J Immunother, 32, 42-53. (if=4.84; ci= 29) 7. Chakroborty D, Chowdhury UR, Sarkar C, Baral R, Dasgupta PS, Basu S, Dopamine regulates endothelial progenitor cell mobilization from mouse bone marrow in tumor vascularization (2008) J Clin Invest. 118, 1380-89. (if=16.56; ci= 97) 8. Baral R* and Chattopadhyay U, Neem (Azadirachta indica) leaf mediated immune activation causes prophylactic growth inhibition of murine Ehrlich carcinoma and B16 melanoma (2004) Int Immunopharmacol, 4, 355-366. (if=2.21; ci= 85) 9. Baral R, Sherrat A, Das R, Foon KA, Bhattacharya-Chatterjee M, Murine Monoclonal Anti-Idiotype Antibody as a surrogate Antigen for human Her2/neu (2001) Int J Cancer, 92, 88-95. (if=4.23; ci= 27) 10. Foon KA, Lutzky J, Baral R, Yannelli JR, Hutchins L, Teitelbaum A, Kashala OL, Das R, Garrison J, Reisfeld RA, Bhattacharya-Chatterjee M, Clinical and Immune responses in advanced melanoma patients immunized with an anti-idiotype (ID) antibody mimicking disialoganglioside GD2 (2000) J Clin Oncol, 18, 376-384. (if=8.77; ci= 155)

412

DAS, KUSAL K. (b 1962), Professor of Physiology, Shri B.M.Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapur


Kusal K Das is personally known to me as a researcher in the similar area of my research interest. Currently he is the Professor of Physiology and Director of Vascular Physiology and Medicine, BLDE (Deemed to be University), Vijayapur. Prof. Das was also a Visiting Professor (2014-2016) at University of Leeds, UK and Tulane University, USA (2017). His area of research is on experimental hypoxia and cell signaling mechanism during heavy metal induced stress and alteration of vascular integrity in both animal and human models. Currently he is working on the HIF-1-dependent responses to hypoxia along with calcium channel blockers linked to cardiovascular and cerebrovascular ischemia (Das KK et al 2018). His research on rodent stroke model is considered as unique for understanding and treatment of stroke patients. He has also applied for a patent on it. He is among the first in the world to establish the link between arsenic toxicities and gold mining activities which made a tremendous impact on Government policy on environmental issues in Karnataka. He has also invented a new method to determine blood vitamin E. Government of Karnataka conferred him “Dr.Raja Ramanna State Scientist Award 2015” for his immense scientific contributions to the society. He is the recipient of “G.P.Chatterjee Memorial Award 2019” and invited to deliver “ISCA Endowment Lecture 2019” by Indian Science Congress Association, Ministry of Science & Technology, Government of India at 106th ISC, Jalandhar on January 3, 2019. He is a Fellow of Royal Society of Biology, UK since 2018.

Proposer: Prof.Srinivas K.Saidapur, Seconder: Prof. N.M.Bujurke


1. Das S, Reddy RC, Chadchan KS , Patil AJ, Biradar MS,.Das KK (2019). Nickel and Oxidative stress: Cell Signaling Mechanisms and Protective Role of Vitamin C. Endocr Metab Immune Disord Drug Targets.; Sep.2019 , (Accepted) (if=2.033, ci=JCR,Pubmed, Scopus,WOS)

2. Das KK, Razzaghi-Asl N.; Tikare SN, Di Santo R, Costi R; Messore A; Pescatori L; Crucitti GC; Jargar JG; Dhundasi SA; Saso L.(2016) Hypoglycemic activity of curcumin synthetic analogues in alloxan-induced diabetic rats. J Enzyme Inhibition Med Chem ; 31(1):99-105 (if=3.638, ci=JCR,Pubmed, Scopus,WOS)

3. Patil SG, Aithala MR, Das KK (2015). Effect of Yoga on Arterial Stiffness in Elderly Subjects with Increased Pulse Pressure: A Randomized Controlled Study. Complement Ther Med.;23(4):562-569 (if=2.084, ci=JCR,Pubmed, Scopus,WOS)

4. Hattiwale SH, Saha S, Yendigeri SM, Jargar JG, Dhundasi SA, Das KK (2013).Protective effect of L-ascorbic acid on nickel induced pulmonary nitrosative stress in male albino rats. Biometals, 26(2), 329-336 (if=2.478, ci=JCR,Pubmed, Scopus,WOS)

5. Chakraborti D, Rahman MM, Murrill M, Das R, Siddayya, Patil SG, Sarkar A, Dadapeer H J, Yendigeri SM, Ahmed R, Das KK (2013).Environmental arsenic contamination and its health effects in a historic gold mining area of the Mangalur greenstone belt of Northeastern Karnataka, India. J Hazard Mater; 15; 262:1048-55 (if=6.434, ci=JCR,Pubmed, Scopus,WOS)

6. Gupta AD, Das SN, Dhundasi SA, Das KK(2008). Effect of garlic (Allium sativum) on heavy metal (nickel II and chromium VI) induced alteration of serum lipid profile in male albino rats.. Int J Environ Res Public Health ; 5(3):147-51 (if=2.145, ci=JCR,Pubmed, Scopus,WOS)

7. Das KK, Gupta AD, Dhundasi SA, Patil AM, Das SN, Ambekar JG.(2007). Protective role of L-ascorbic acid on antioxidant defense system in erythrocytes of albino rats exposed to nickel sulfate.. Biometals; 20(2):177-84. (if=2.478, ci=JCR,Pubmed, Scopus,WOS)

8. Patil AJ, Bhagwat VR, Patil JA,Dongre NN, Ambekar JG, Jailkhani R, Das KK.(2006).Effect of lead (Pb) exposure on the activity of superoxide dismutase and catalase in battery manufacturing workers (BMW) of Western Maharashtra (India) with reference to heme biosynthesis Int J Environ Res Public Health ; 3(4):329-37. (if=2.145, ci=JCR,Pubmed, Scopus,WOS)

9. Das KK, Dasgupta S.(2002). Effect of nickel sulfate on testicular steroidogenesis in rats during protein restriction.. Environ Health Perspect; 110(9):923-6. (if=8.44, ci=JCR,Pubmed, Scopus,WOS)

10. Das KK, DasguptaS.(2000). Effect of nickel on testicular nucleic acid concentrations of rats on protein restriction..Biol Trace Elem Res ; 73(2):175-80 (if=2.361, ci=JCR,Pubmed, Scopus,WOS)

413

DUTTA, RANJNA C (FOR CHHABRA) (b 1966), Innovator, DST, C/o Excel Matrix Biological Devices Pvt. Ltd., Hyderabads


A bio-medical researcher Ranjna started with the synthesis and evaluation of immunomodulating peptides for targeting liposomes to macrophages, under the supervision of Padamshri Dr. NityaNand at CDRI (1987-93), Lucknow and ended up joining hands with Dr. A.K. Dutta, as founder Director of ExCel-Matrix Biological Devices P Ltd, India’s first and perhaps the only innovation based company in Tissue Engineering and Regenerative Medicine in 2005-06. Their efforts in the field have led to ‘DST-Lockheed Martin Innovation Gold medal’ in 2009 and ‘Leaders of Innovation fellowship’ from ‘Royal Academy of Engineers, UK’ in 2015. Ranjna was associated with NII and ICGEB New Delhi (1994-99), IICT (1999-02) and NIN (2009-12), Hyderabad and IISc, Bangalore (2016-2017) for different projects, collaborative as well as independent. She also worked in the BMBCB department of Northwestern University, Illinois, USA as visiting post-doctoral fellow (2002-03). She received ‘Prolog to Discovery’ award at IICT for her project and also published in International Journals (cumulative impact >65, citations >445). Ranjna is an invited member of ‘American Nano-society’, international reviewer’s panel of many reputed journals and is also the managing editor of special issue on ‘Cell Dynamics in 3D culture’ in the ‘Frontiers in Biosciences’. She is currently engaged in the design and synthesis of ECM-mimicking macro-conjugates for creating instructive 3D-scaffolds that in addition to TE and RM can find applications in therapeutic delivery. In view of her significant contribution in the field of Medical Biotechnology, I feel pleasure in recommending Dr. Ranjna C. Dutta for the fellowship of NASI.

Proposer: Prof. Bikramjit Basu, Seconder: Dr. G. Bhanuprakash Reddy


1. S. P. Singh, R. Chhabra and V. M. L. Srivastava, (1992) Respiratory burst in peritoneal exudate cells in response to a modified tuftsin, Experientia (now Cellular & Molecular Life Sciences) , 48(10): 994-996. (if=5.788, ci=13)

2. G. P. Talwar, S. Shah, S. Mukherjee and R. Chhabra, (1997) Induced termination of pregnancy by purified extracts of Azadirachta indica (Neem): Mechanisms involved, Am J Reproductive Immunol 37(6): 485-491. (if=3.013, ci=54)

3. Ranjna C. Dutta, A. Puri and N. Anand, (2001) The Immunomodulatory potential of hydrophobic analogues of rigin and their role in providing protection against Plasmodium berghei infection in mice, Int Immunopharm 1: 843-855 (if=3.067, ci=11)

4. Ranjna C Dutta, (2002) Peptide immunomodulators versus infection: an analysis. Immunol Letters 83: 153-161. (if=2.86, ci=27)

5. Ranjna C. Dutta, (2007) Drug Carriers in Pharmaceutical Design; Promises and Progress Curr Pharm Design 13: 761-769. (if=3.0, ci=61)

6. Ranjna C. Dutta, Sushma Nagpal and Dinakar M. Salunke, (2008) Functional mapping of apidaecin through secondary structure correlation, Int J Biochem & Cell Biol 40: 1005-1015 (if=4.092, ci=18)

7. Ranjna C. Dutta and Aroop K. Dutta, (2009) Cell interactive 3D scaffold; advances and applications. Biotech Advances 27: 334-339. (if=11.866, ci=172)

8. Ranjna C. Dutta and Aroop K. Dutta, (2010) Comprehension of ECM-Cell dynamics: A prerequisite for tissue regeneration, Biotech Advances 28: 764-769. (if=11.866, ci=40)

9. Ranjna C. Dutta and Aroop K. Dutta, (2012) ECM analog technology for 3D cell culture, Frontiers in Bioscience (Scholar/Elite Ed), 4:1043-1048. (if=2.484, ci=2)

10. Ranjna C. Dutta, Madhuri Dey, Aroop K. Dutta and Bikramjit Basu, Competent Scaffolds for Tissue Engineering: Important considerations, (2017), Biotech Advances, 35(2), 240-250. (if=11.866, ci=15)

414

GANGADHAR, BANGALORE N. (b 1955), Senior Professor of Psychiatry & Director, National Institute of Mental Health And Neurosciences, Bengaluru


Prof Gangadhar has done pioneering research in the areas of electroconvulsive therapy (ECT), yoga therapy in psychiatric disorders as well as neurobiology of schizophrenia. Seminal studies by Prof Gangadhar helped standardize ECT for psychiatric disorders. Findings from these studies have facilitated therapeutic use of ECT in depression, schizophrenia, bipolar affective disorder among others. Prof Gangadhar has done rigorous research on the use of yoga therapy in psychiatric disorders especially schizophrenia and depression, which led to establishment of yoga as a specialized clinical service at NIMHANS and recognition from the National Institute of Health and Care Excellence (NICE, UK) as “high quality” evidence for use of yoga in schizophrenia (https://www.nice.org.uk/guidance/qs80). In conclusion, Prof Gangadhar, an outstanding psychiatrist has carried out path-breaking research, which has had a direct translational impact in the treatment of psychiatric disorders by non-pharmacological methods, such as ECT and yoga that is of immense importance for our country.

Proposer: Prof. Vijayalakshmi Ravindranath, Seconder: Prof. V. Nagaraja


1. Gangadhar BN, Kapur RL and Kalyanasundaram S. 1982. Comparison of electroconvulsive therapy with imipramine in endogenous depression: a double blind study. The British journal of psychiatry 141:367-71. (if=7.06, ci=149)

2. Gangadhar BN, Ancy J, Janakiramaiah N and Umapathy C. 1993. P300 amplitude in non-bipolar, melancholic depression. Journal of affective disorders. 28(1):57-60. (if=3.786, ci=128)

3. Radhakrishnan N and Gangadhar BN. Estimating regularity in epileptic seizure time-series data. 1998. A complexity-measure approach. IEEE engineering in medicine and biology magazine. 17(3):89-94 (if=26.303, ci=205)

4. Janakiramaiah N, Gangadhar BN, Naga Venkatesha Murthy PJ, Harish MG, Subbakrishna DK and Vedamurthachar A. 2000. Antidepressant efficacy of SKY in melancholia: a randomized comparison with ECT and imipramine. Journal of affective disorders. 57:255-9 (if=3.786, ci=389)

5. Jayakumar PN, Venkatasubramanian G, Gangadhar BN et al. 2005. Optimized voxel-based morphometry of gray matter volume in first-episode, antipsychotic-naive schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. 29(4):587-91. (if=4.185, ci=106)

6. Vedamurthachar A, Janakiramaiah N, Hegde JM, Shetty TK, Subbakrishna DK, Sureshbabu SV and Gangadhar BN. 2006. Antidepressant efficacy and hormonal effects of SKY in alcohol dependent individuals. Journal of affective disorders. 94(1-3):249-53.(if=3.786, ci=160)

7. Duraiswamy G, Thirthalli J, Nagendra HR and Gangadhar BN. Yoga therapy as an add-on treatment in the management of patients with schizophrenia-a randomized controlled trial 2007. Acta psychiatrica Scandinavica. 116:226-32. (if=5.605)

8. Venkatasubramanian G, Chittiprol S, Neelakantachar N, Naveen MN, Thirthall J, Gangadhar BN, Shetty KT. 2007. Insulin and insulin-like growth factor-1 abnormalities in antipsychotic-naive schizophrenia. The American journal of psychiatry. 164:1557-60 (if=13.391, ci=206)

9. Udupa K, Sathyaprabha TN, Thirthalli J, Kishore KR, Lavekar GS, Raju TR, Gangadhar BN. 2007. Alteration of cardiac autonomic functions in patients with major depression: a study using heart rate variability. Journal of affective disorders. 100:137-41 (if=3.786, ci=193)

10. Mehta UM, Thirthalli J, Subbakrishna DK, Gangadhar BN, Eack SM and Keshavan MS. 2013. Social and neuro-cognition as distinct cognitive factors in schizophrenia: a systematic review. Schizophrenia research. 148:3-11. (if=4.748, ci=87)

415

GARG, PANKAJ (b 1972), Senior Surgeon Colorectal & Laparoscopic, Fortis Super Hospital, Mohali


Dr Garg a renowned Surgeon of international fame. He is one of the rare clinicians in the country who has invented 4 new operations (PERFACT, Tube in tract, LOCULA, FATS) to treat complex dreaded illnesses. PERFACT procedure is quite effective to treat highly complex fistula-in-ano, a disease for which there is no good treatment available. (Published in highest ranking Colorectal journal in world: Impact factor -3.75). Presentations (>60) in top US & European conferences. Consecutive invitations for last 8 years from Top American Surgical Societies to give lectures. Surgeons from across the globe are coming to him to learn the procedures he has invented. He is also teaching clinical research to medical students from all over the world. Dr Garg has two discoveries to his credit. He discovered that water-jet stream used in toilet commodes could cause anterior fissure-in-ano. This discovery would help prevent this painful disease in large number of people. He has also innovated three New treatment concepts (TONE, LOABAC & ECLIPs). With Dr Garg’s new treatments, TONE & LOABAC (Published in highest ranking Colorectal journal in world), a large proportion of these operations can be averted in lakhs of people and save enormous resources. He is bestowed with the highest award in the field of Science & Technology in states of Haryana, Punjab & Chandigarh and top surgical societies of world (SAGES-USA, ASCRS-USA, ASI-India). Hundreds of patients from 30 countries came to Panchkula (Chandigarh) to get treated by him [not for cheaper treatment (medical tourism), but for his technical expertise].

Proposer: Dr. Javed N. Agrewala, Seconder: Dr. I.B.S. Passi


1. Jagat Narula, Pankaj Garg, Stephen Achenbach, Sadako Motoyama, Renu Virmani,William Strauss. 2008. Arithmetic of Vulnerable Plaques for Noninvasive Imaging.Nature Clinical Practice Cardiovascular Medicine. 5:, S1-9 (if=9.18, ci=121)

2. Pankaj Garg. 2009. Lichtenstein Hernioplasty Versus Totally Extraperitoneal Laparoscopic Hernioplasty in treatment of Recurrent Inguinal Hernia-A Prospective Randomized Trial. Annals of Surgery Sep;250(3):504. (Highest ranking Surgery Journal in the world)(if=8.32, ci=65)

3. Pankaj Garg. 2016. Why should a good proportion of Hemorrhoids not be operated? – Let’s TONE up. Diseases Colon Rectum (Being Published)(Highest ranking Colorectal Surgery Journal in the world) (if=3.75, ci=Being Published)

4. Pankaj Pankaj Garg, Pratiksha Singh. 2016. Post defecation cleansing methods: Tissue paper or water? An analytical review.Diseases Colon Rectum (Being Published) (Highest ranking Colorectal Surgery Journal in the world) (if=3.75, ci= (Being Published))

5. Pankaj Garg, Mahesh Rajgopal, Vino Varghese, Mohamed Ismail. 2009. Laparoscopic total extraperitoneal inguinal hernia repair with non fixation of the mesh in 1692 hernias. Surgical Endoscopy 23:1241-5 (Highest ranking Laparoscopic Surgery Journal in the world)(if=3.26, ci=52)

6. Pankaj Garg, Geetha R Menon, Mahesh Rajgopal, Mohamed Ismail. 2010. Laparoscopic total extraperitoneal repair in recurrent inguinal hernias.Surgical Endoscopy 24(2):450-4 (Highest ranking Laparoscopic Surgery Journal in the world) (if=3.26, ci=20)

7. Pankaj Garg, Mohamed Ismail. Horizontal mattress suture at Garg Pankaj, Nair S, Shereef M, Thakur JD, Nain N, Menon GR, Ismail M. 2011. Mesh fixation compared to nonfixation in total extraperitoneal inguinal hernia repair: a randomized controlled trial in a rural center in India. Surgical Endoscopy 25(10):3300-6 (Highest ranking Laparoscopic Surgery Journal in the world) (if=3.26, ci=19)

8. Pankaj Garg, Jai Deep Thakur, Mahak Garg, Geetha Menon. 2012. Single-incision laparoscopic cholecystectomy vs. conventional laparoscopic cholecystectomy : A meta-analysis of randomized controlled trials. Journal of Gastrointestinal Surgery 16(8):1618-28(if=2.80, ci=76)

9. Pankaj Garg, Mahak Garg. 2015. Perfact procedure: A new concept to treat highly complex anal fistula. World J Gastroenterology 21(13): 1-10 (New Operation Invented by Dr Garg) (if=2.39, ci=2)

10. Pankaj Garg, Jeremy Song, Amarjit Bhatia, HemantKalia, Geetha Menon. 2010. The efficacy of Anal Fistula Plug in Fistula-in-ano: A systematic review. Colorectal Disease 12(10):965-70 (if=2.35, ci=102)

416

GHATAK, ASHIM (b. 1957) Chief Scientist & Head & Professor, AcSIR, Division of Clinical & Experimental Medicine, Central Drug Research Institute, Lucknow


Dr. Ashim Ghatak is among the few clinical scientists of the country who have made significant contribution to basic sciences. His elucidation of pathophysiology of heart diseases– a definitive role of increased oxidative stress in ischemic heart patients, which attenuates with Vitamin E 400 mg daily orally in addition to standard treatment in the first few days in acute myocardial infraction and an important role of oxidative stress and serotonin in heart failure, where standard treatment along with vitamin E 400 mg daily orally for 4 weeks significantly improves the congestive heart failure. He has also elucidated the Nitric Oxide pathways in Essential Hypertension and shown a reversible suppression of Nitric Oxide with standard treatment along with vitamin E orally. He has also recently identified newer Biomarkers for lifestyle diseases especially in metabolic syndrome and various cancers. Dr. Ghatak has been planning, conducting and coordinating phase- I to IV clinical trials of CDRI drugs – Centchroman, Gugulipid, injection α-β arteether& CDRI 80/53 and these have been successfully marketed. He has conducted and coordinated clinical trials of other CDRI candidate drugs. His publications which have been cited widely - Google Scholar-330 citations & h-index-7; and Web of Science -122 citations & h-index-3 and has been awarded and recognized by his peers . He has successfully filed many national and international patents. He has been responsible for the implementation of Good Clinical Practices and important Ethical issues in CDRI.

Proposer: Prof. B.N. Dhawan, Seconder: Dr. V.P. Kamboj Ten Best Publications: 1. Ghatak, A; Brar, MJS; Agarwal, A; Goel, N; Rastogi, AK; Vaish, AK; Sircar, AR; Chandra, M ; 1996; Oxy free radical system in heart failure and therapeutic role of oral vitamin E; International Journal of Cardiology; 57 (2); 119 -127.( if=4.036 WoS ci =63 GS ci=109) 2. Chandra, M; Chandra, N; Agrawal, R; Kumar, A; Ghatak, A; Pandey, Vc; 1994; The Free-Radical System In Ischemic-Heart-Disease; International Journal Of Cardiology; 43 (2) 121- 125. (if=4.036 WoS ci =43 GS ci=65) 3. Gupta, RR; Agrawal, CG; Singh, GP; Ghatak A ; 1994; A Lipid-Lowering Efficacy Of Psyllium Hydrophilic Mucilloid In Non-Insulin-Dependent Diabetes-Mellitus With Hyperlipidemia. Indian Journal Of Medical Research, , 100, 237 -241. (if=1.396 WoS ci =16 GS ci=51) 4. A Ghatak, OP Asthana; 1995; Recent trends in hyperlipoproteinemias and its pharmacotherapy, Indian Journal Of Pharmacology 27 (1) 14.( if=0.691 GS ci=43) 5. PA Sadiq, A Puri, M Dikshit, A Ghatak, SK Dwivedi, VS Narain, RK Saran ; 2005 ; Profile And Prevalence Of Aspirin Resistance In Indian Patients With Coronary Artery Disease, ... Indian Heart Journal; 57 , 658- 661. (GS ci=32) 6. M Chandra, K Surendra, RK Kapoor, A Ghatak, G Kaur, NR Pandey; 2000; Oxidant stress mechanisms in heart failure... Bollettino Chimico Farmaceutico, 139 (3), 149. (GS ci=11) 7. OP Asthana, JS Srivastava, A Ghatak, SPS Gaur, BN Dhawan ; 1996; Safety and tolerability of bacosides A and B in healthy human volunteers; Indian Journal Of Pharmacology, 28 (10) 37. (if=0.691 GS ci=8) 8. VV Bhosale, SC Inamdar, VB Karande, SR Burute, MB Murthy, A Ghatak ; 2014; Beneficial effects of Nebivolol in comparison with Atenolol on safety and tolerability in essential hypertension; Journal Of Clinical And Diagnostic Research ; 8 (6) ;HC01 -HCO4. (GS ci=4) 9. G Monte, RP Moerschell, A Ghatak, E Melissari; 1993; C4b-Binding Protein -An Update; Thrombosis And Haemostasis; 69(1)86. (if=4.984 GS ci=3) 10. AK Vaish, S Kumar, M Chandra, A Ghatak, AK Balapure, AR Sircar ; 2001; Effect of ALPHA- Tocopherol on oxidative stress and antioxidant enzymes in essential hypertension., Journal Of Internal Medicine Of India; 4 55- 57 (GS ci=2)

417

KATARE, OM PRAKASH (b 1959), Professor (Pharmaceutics), University Institute of Pharmaceutical Sciences, Director, Research Promotion Cell (RPC), Panjab University,Chandhigarh.


A drug delivery expert par excellence, Professor Katare is recognized globally as an accomplished scientist in the sphere of Liposome Technology, with more than 120 International and National research publications, several book chapters and patents (5 granted out of 18 filed). He guided successfully as many as 10 Ph.D. thesis and completed several ambitious research projects. But, the hallmark of Prof. Katare’s work relates to Academia-Industry collaborative ventures which, to be rated very high, culminated into the tech transfers and commercialization of the cutting-edge technologies. The three novel liposome and nanotechnology based pharmaceutical products (Psorisome™, Lipotar S™, Lipotar SS™) for the treatment of ‘difficult-to-treat’ skin ailment, Psoriasis, are in the market. For this contribution, Prof. Katare has received high-end awards and accolades including DBT National Technology Award by the then President of India, (Late) Dr A P J Abdul Kalam (2007), IABMS Best Patent Award (2012), OPPI Scientist Award (2011), and Illustrious Alumnus Award (2016) by Dr H S Gaur Vishwavidyalaya etc. Currently, after holding several prestigious University positions, he is serving as Director, Research, Panjab University and engaged himself intensively and extensively in formulating research plans and policies. In a nutshell, the collaborative efforts of Prof. Katare in the field of translational research comprising both basic and applied sciences has contributed substantially in creating the culture and climate for the current and younger generation.

Proposer: Dr. P.K. Chakraborti, Seconder: Prof. Arun Kumar Grover


1. Agarwal R., Katare O. P. and Vyas S. P. 2001. Preparation and In-Vitro Evaluation of Liposomal/Niosomal Delivery Systems of Antipsoriatic Drug Dithranol. International Journal of Pharmaceutics 228(1-2), 43-52. (if=4.01, ci=200)

2. Kumar R. and Katare O. P. 2005. Lecithin Organogels as a Potential Phospholipid Structured System for Topical Drug Delivery: A Review. AAPS PharmSciTech 6 (2), E298-E310. (if=1.64, ci=169)

3. Raza K., Singh B., Singal P., Wadhwa S. and Katare O.P. 2013. Systematically optimized biocompatible isotretinoin-loaded solid lipid nanoparticles (SLNs) for topical treatment of acne. Colloids and Surfaces B: Biointerfaces 105C, 67-74 (if=4.4, ci=53)

4. Bhatia A., Kumar R. and Katare O. P. 2004 Tamoxifen Entrapped Topical Liposomes: Development, Characterization and In-Vitro Evaluation. Journal of Pharmacy and Pharmaceutical Sciences, S 7(2), 252-259 (if=1.86, ci=146)

5. Shukla A., Katare O. P., Singh B. and Vyas S. P. 2010. M-cell Targeted Delivery of Recombinant Hepatitis B Surface Antigen Using Cholera Toxin B Subunit Conjugated Bilosomes. International Journal of Pharmaceutics 385(1), 47-52 (if=4.01, ci=48)

6. Madan J., Pandey R.S., Jain V., Katare O.P., Chandra R.and Katyal A. 2013. Poly (ethylene)-glycol conjugated solid lipid nanoparticles of noscapine improve biological half-life, brain delivery and efficacy in glioblastoma cells. Nanomedicine: Nano (if=5.43, ci=54)

7. Raza K., Singh B., Lohan S., Sharma G., Negi P., Yachha Y. and Katare O.P. 2013. Nano-lipoidal carriers of tretinoin with enhanced percutaneous absorption, photostability, biocompatibility and anti-psoriatic activity. International Journal of Phar (if=4.01, ci=55)

8. Raza K., Singh B., Singla S., Wadhwa S, Garg B., Chhibber S. and Katare O.P. 2013. Nanocolloidal carriers of isotretinoin: antimicrobial activity against Propionibacterium acnes and dermatokinetic modeling. Molecular Pharmaceutics 10(5), 19558-63 (if=4.38, ci=15)

9. Jain A., Jain A., Garg N.K., Tyagi R.K., Singh B., Katare O.P., Webster T. And Soni V. 2015. Surface engineered polymeric nanocarriers mediate the delivery of transferrin–methotrexate conjugates for an improved understanding of brain cancer. Acta (if=6.02, ci=7)

10. Bhatia A., Singh B., Raza K., Wadhwa S. and Katare O.P. 2013. Tamoxifen-loaded Lecithin Organogel (LO) for Topical Application: Development, Optimization and Characterization. International Journal of Pharmaceutics 444(1-2), 47-59 (if=4.01, ci=25)

418

KULKARNI, MAHESH JAGDISHRAO (b 1971), Principal Scientist, National Chemical Laboratory, Pune


Dr. Mahesh Kulkarni has contributed significantly in understanding protein glycation in diabetes. Currently diabetes diagnosis and management majorly depend upon the measurement of HbA1c. Plasma albumin levels are negatively associated with HbA1c. Dr. Kulkarni’s work has explained the precise mechanism by which albumin influences HbA1c. His study has demonstrated that albumin protects hemoglobin glycation by scavenging glucose. However, if lysine residues of albumin are glycated, then it loses its ability to scavenge glucose and protect hemoglobin glycation (ACS Omega, 2018). Further, lower levels of albumin are associated with increased glycation of plasma proteins and HbA1c (J Proteome Res, 2012). Thus, low levels of albumin in diabetes could be potential risk factor for glycation induced complications. Therefore, his study proposes albumin level and its glycation status to be quantified in conjunction with HbA1c for better management of diabetes (Expert Rev Proteom. 2017). In this regard, Dr. Kulkarni’s group has developed diagnostic fragment ion library for mass spectrometry-based quantification of glycated peptides of albumin, and identified glycation sensitive lysine residues that could be useful to assess the degree of glycation in diabetes (Mol Cell Proteom 2015). These peptides are being validated for prediction of prediabetes. Glycated albumin also elicits immune response and form complex with immunoglobulins called circulating immune complexes (CICs). Proteomic analysis of CICs in clinical plasma of diabetic subjects revealed elevated levels of glycated albumin in the CICs, which could serve as a reliable biomarker for prediction of diabetic complications nephropathy (Mol Cell Proteomics.2016).

Proposer: Prof. Sourav Pal, Seconder: Prof. M. Udayakumar


1. Jagadeeshaprasad MG, Subramani V, Unnikrishnan AG, Kulkarni MJ*. Albumin abundance and its glycation Status Determine Hemoglobin Glycation. ACS Omega, 2018 (http://dx.doi.org/10.1021/acsomega.8b01702)

2. Banarjee R, Sharma A, Bai S, Deshmukh A, Kulkarni MJ*. Proteomic study of endothelial dysfunction induced by AGEs and its possible role in diabetic cardiovascular complications. J Proteomics. 2018 Sep 15;187:69-79. (if=3.7, ci=4)

3. Batkulwar KB, Godbole RK, Banarjee R, Kassaar O, Williams R*, Kulkarni MJ* Advanced glycation end products modulate amyloidogenic APP processing and Tau phosphorylation: a mechanistic link between glycation and the development of Alzheimer’s disease. ACS Chem Neurosci. 2018 May 16;9(5):988-1000 (if=4.2, ci=5)

4. Kazi RS, Banarjee RM, Deshmukh AB, Patil GV, Jagadeeshaprasad MG, Kulkarni MJ*. Glycation inhibitors extend yeast chronological lifespan by reducing advanced glycation end products and by back regulation of proteins involved in mitochondrial respiration. J Proteomics. 2017 Mar 6;156:104-112. (if=3.7, ci=10)

5. 17. Bhat S, Jagadeeshaprasad MG, Patil YR, Shaikh ML, Regin BS, Mohan V, Giri AP, Balasubramanyam M, Boppana R, Kulkarni MJ*. Proteomic insight reveals elevated levels of albumin in circulating immune complexes in diabetic plasma. Mol Cell Proteomics. 2016 15:2011-20 (if=5.2, ci=8)

6. Korwar AM, Vannuruswamy G, Jagadeeshaprasad MG, Ramesha JH. Bhat S, Regin BS, Ramaswamy S, Giri AP, Mohan V, Balasumbramanyam M and Kulkarni MJ*. Development of diagnostic fragment ion library for glycated peptides of Human serum albumin: Targeted quantification in prediabetic, diabetic and microalbuminuria plasma by PRM, SWATH and MSE. Molecul (if=5.2, ci=29)

7. Golegaonkar SB, Tabreza SS, Pandita A, Shalini SA, Jagadeesha Prasad MG, Bansode SB, Gopalan SC, Kulkarni MJ*, and Mukhopadhyay A*. Rifampicin reduces Advanced Glycation End products and activates DAF-16 to increase life span in Caenorhabditis elegans. (2015). Aging Cell. 2015 Jun;14(3):463-73. (if=7.6, ci=23)

8. Kesavan SK, Bhat S, Golegaonkar SB, Jagadeeshaprasad MG, Deshmukh AB, Patil HS, Bhosale SD, Shaikh ML, Thulasiram HV, Boppana R, Kulkarni MJ*. Proteome wide reduction in AGE modification in streptozotocin induced diabetic mice by hydralazine mediated transglycation. Scientific Reports. 2013 Oct 15;3:2941. doi: 10.1038/srep02941. (if=4.2, ci=21)

9. Bansode SB, Chougale AD, Joshi RS, Giri AP, Bodhankar SL, Harsulkar AM, Kulkarni MJ*. Proteomic analysis of protease resistant proteins in the diabetic rat kidney. Mol Cell Proteomics. 2013 Jan;12(1):228-36 (if=5.2, ci=24)

10. Bhonsle HS, Korwar AM, Kote SS, Golegaonkar SB, Chougale AD, Shaik ML, Dhande NL, Giri AP, Shelgikar KM, Boppana R, Kulkarni MJ*. Low plasma albumin levels are associated with increased plasma protein glycation and HbA1c in diabetes. J Proteome Res. 2012 Feb 3;11(2):1391-6. (if=3.9, ci=51)

419

KUMAR, RAJEEV (b 1972), Professor of Urology and Associate Dean (Academics), All India Institute of Medical Sciences, New Delhi


The nominee’s primary contribution has been a combination of clinical and basic research in the evaluation and management of male infertility. Infertile men are often subjected to investigations and treatments, including surgery, with little scientific justification. The nominee has questioned the role of such investigations, such as screening for tuberculosis, in infertile men (1-5). He has evaluated the role of empirical drug therapies (6-11) and suggested simplified algorithms and investigative protocols to minimize procedures (12-17). He has developed two new microsurgical techniques to simplify complex procedures (18-23). With a collaborative team for basic research, including an earlier ICMR task force project, they have evaluated genetic abnormalities including Y chromosome microdeletions, mitochondrial DNA mutations, and the role of oxidative stress in male infertility (24-54). They have identified novel mutations in the genome of infertile men and developed a multiplex PCR technique to minimize diagnostic evaluation. His second area of research is multiparametric magnetic resonance techniques in early prostate cancer diagnosis. Data gathered from in-vitro and in-vivo imaging MR studies (55-57) was used to determine cut-off values between normal, benign and malignant tissues (58). These values were validated on a cohort of men with suspected prostate cancer who underwent MR studies followed by prostate biopsy (59-60). Additional MR techniques were evaluated for targeting such biopsies (61-64) followed by the establishment of pre-biopsy MR protocols for detecting prostate cancer with high specificity which could increase diagnostic yield while avoiding unnecessary biopsies (65-70). (References as per Annexure 2-updated 2018).

Proposer: Prof. Rakesh Kapoor, Seconder: Prof. Veereshwar Bhatnagar


1. Javali TD, Dwivedi DK, Kumar R, Jagannathan NR, Thulkar S, Dinda AK (2014) Magnetic resonance spectroscopy imaging-directed transrectal ultrasound biopsy increases prostate cancer detection in men with prostate-specific antigen between 4-10 ng/mL an (if=2.409, ci=10)

2. Kumar V, Jagannathan NR, Thulkar S, Kumar R (2012) Prebiopsy magnetic resonance spectroscopy and imaging in the diagnosis of prostate cancer. Int J Urol. 2012; 19:602-13 (if=2.409, ci=10)

3. Kumar R, Anand A, Saxena V, Seth A, Dogra PN, Gupta NP (2008) Safety and efficacy of PCNL for management of staghorn calculi in pediatric patients. J Pediatr Urol. 2011;7(3):248-51 (if=1.611, ci=29)

4. Kumar R, Mukherjee S, Gupta NP (2010) Intussusception Vasoepididymostomy with Longitudinal Suture Placement for Idiopathic Obstructive Azoospermia. J Urol. 2010 ;183:1489-92 (if=4.471, ci=21)

5. Kumar R, Nayyar R, Kumar V, Gupta NP, Hemal AK, Jagannathan NR, Dattagupta S, Thulkar S (2008) Potential of Magnetic Resonance Spectroscopic Imaging in Predicting Absence of Prostate Cancer in Men with Serum Prostate-Specific Antigen Between 4 and 10 (if=2.188, ci=46)

6. Kumar R, Gautam G, Gupta NP (2006) Drug therapy for idiopathic male infertility: rationale versus evidence. J Urol. 2006;176:1307-1312 (if=4.471, ci=55)

7. Kumar V, Jagannathan NR, Kumar R, Das SC, Jindal L, Thulkar S et al. (2006) Correlation between metabolite ratios and ADC values of prostate in men with increased PSA level. Magn Reson Imaging. 2006;24:541-8 (if=2.090, ci=52)

8. Kumar R, Kumar M, Jagannathan NR, Hemal AK, Gupta NP (2004) Proton Magnetic Resonance spectroscopy using a body coil in the diagnosis of carcinoma prostate. Urol Research. 2004;32:36-40 (if=1.000, ci=23)

9. Gupta NP, Kumar R. Lycopene therapy in idiopathic male infertility—a preliminary report. Int Urol Nephrol. 2002;34:369-72 (if=1.519, ci=81)

10. Hemal AK, Gupta NP, Kumar R. Comparison of retroperitoneoscopic nephrectomy with open surgery for tuberculous nonfunctioning kidneys. J Urol. 2000;164:32-5 (if=4.471, ci=42)

420

MISHRA, PRABHAT RANJAN (b 1970), Principal Scientist, Pharmaceutics and Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow


Dr. Prabhat Ranjan Mishra has made outstanding contribution in mechanistic understanding of targeted nano-therapeutics through ligand-receptor interactions, receptor mediated endocytosis and endosomal pH responsiveness to achieve higher therapeutic index with low toxicity of drugs. He established that dose of amphotericin B gets reduced significantly using phosphatidylserine anchored nanocapsules, providing a new insight for selected drug delivery to specialized macrophages through “eat me” signal (Br. J Pharmacol 2014; IF 6.81; J. Antimicrob. Chemother. 2012; IF 5.22), while higher localization of amphotericin B resulted in killing tissue resident pathogens through sulfated derivative of common sugar (4-SO4GalNAc) anchored on liposomes (Nanomedicine 2012; IF 6.5). He established the role of pyridoxine thethered nanoparticles in escaping lysosomal degradation at low pH to achieve fifteenfold reduction in therapeutic dose of doxorubicin with enhanced antitumor efficacy (ACS Appl. Mater. Interfaces, 2016; IF 8.1). He demonstrated significant reduction in toxicity of paclitaxel alongwith reduced lung metastasis using hyaluronic acid anchored paclitaxel nanocrystals that involved improved CD44 receptor mediated endocytosis (RSC Advances 2016;IF 2.94) while enhancing oral bioavailability through reversible P-gp modulation with significant reduction in tumor growth ensuing patient friendly “chemotherapy at home”. (Acta Biomaterialia, 2015; IF 6.38; Colloids & Surfaces B: Biointerfaces 2017; IF 3.99). He elucidated the role of anisamide anchored lyotropic nano-liquid crystals, demonstrating image-guided chemotherapy for breast cancer with significant enhanced efficacy (ACS Appl. Mater. Interfaces, 2018; IF 8.1). Overall, his contributions signify a major role in establishing specific delivery of drugs through innovative nanotherapeutics thereby bypassing the otherwise established biological barriers.

Proposer: Dr. Madhu Dikshit, Seconder: Padma Shri Dr. Nitya Anand


1. D. Singodia, A. Verma, R.K. Verma, P. R. Mishra (2012) Investigations on Alternate Approach to Target Mannose Receptors on Macrophages using 4-Sulfated N-Acetyl Galactosamine more Efficiently as Compared to Mannose Decorated Liposomes : An Application in Drug Delivery, Nanomedicine, Nanotechnology, Biology and Medicine 8 (4): 468-477 (Corres Auth (if=6.5, ci=31)

2. Shaswat Kansal, Rati Tandon, Pankaj Dwivedi, Pragya Misra, P.R.P Verma, Anuradha Dube and Prabhat Ranjan Mishra* (2012) Development of oil templated nanocapsules bearing doxorubicin for macrophage targeting through Phosphatidylserine ligand: A system for intervention in Visceral Leishmaniasis J. Antimicrob. Chemother. 67 (11), 2650-2660 (Corre Auth (if=5.22, ci=42) 3. S Kansal, R Tandon, A Verma, P Misra, AK Choudhary, R Verma, PRP Verma, A Dube, PR Mishra* (2014) Coating doxorubicin loaded nanocapsule with alginate enhances therapeutic efficacy against Leishmania in hamsters by inducing Th1 type immune responses Br. J. Pharmacol. 171(17):4038-50 (Corresponding author) (if=6.81, ci=11)

4. Gupta PK, Jaiswal AK, Asthana S, Teja B V, Shukla P, Shukla M, Sagar N, Dube A, Rath SK, Mishra PR (2015) Synergistic enhancement of parasiticidal activity of amphotericin B using copaiba oil in nanoemulsified carrier for oral delivery: an approach for non-toxic chemotherapy. Br J Pharmacol. 72(14):3596-610. (Corresponding author) (if=6.81, ci=06)

5. S Sharma, A Verma, G Pandey, N Mittapelly, PR Mishra (2015) Investigating the role of Pluronic-g-Cationic polyelectrolyte as functional stabilizer for nanocrystals: Impact on Paclitaxel oral bioavailability and tumor growth Acta Biomaterialia 26: 169-183 (Corresponding author) (if=6.38, ci=19)

6. Shweta Sharma, Ashwni Kumar Verma, Jyotsana Singh, B Venkatesh Teja, Naresh Mittapelly, Gitu Pandey, Sandeep Urandur, Ravi Shukla, Rituraj Konwar, Prabhat Ranjan Mishra* (2016) Vitamin B6 Tethered Endosomal pH Responsive Lipid Nanoparticles for Triggered Intracellular Release of Doxorubicin ACS Appl. Mater. Interfaces 8 (44), 30407–30421 (Corr Auth (if=8.1, ci=14) 7. Ashwni Verma,Shweta Sharma,Pramod Kumar Gupta,Awadhesh Singh,B Venkatesh Teja, Pankaj Dwivedi,Girish Kumar Gupta, Ritu Trivedi,Prabhat Ranjan Mishra* (2016) Vitamin B12 functionalized layer by layer calcium phosphate nanoparticles: A mucoadhesive and pH responsive carrier for improved oral delivery of insulin Acta Biomaterialia 31:288-300(Corr Auth (if=6.38, ci=32)

8. Shweta Sharma, Jyotsana Singh, Ashwni Verma, Banala Venkatesh Teja, Ravi P Shukla, Sandeep K Singh, Veena Sharma, Rituraj Konwar, PR Mishra (2016) Hyaluronic acid anchored paclitaxel nanocrystals improves chemotherapeutic efficacy and inhibits lung metastasis in tumor-bearing rat model RSC Adv. 6 (77) 73083-73095. (Corresponding author) (if=2.94, ci=10)

9. Gitu Pandey, Naresh Mittapelly, Venkatesh Teja Banala, and Prabhat Ranjan Mishra* (2018) Multifunctional Glycoconjugate Assisted Nanocrystalline Drug Delivery for Tumor Targeting and Permeabilization of Lysosomal Mitochondrial Membrane ACS Applied Materials & Interfaces 10 (20), 16964–16976 (2018) (Corresponding author) (if=8.1, ci=01)

10. S.Urandur, Venkatesh T.Banala, Ravi P.Shukla, N. Mittapelly, G.Pandey, N. Kalleti, K.Mitra, S.K.Rath, R.Trivedi, P.Ramarao, P.R. Mishra (2018) Anisamide Anchored Lyotropic Nano Liquid Crystalline Particles with AIE Effect-A Smart Optical Beacon for Tumor Imaging and Therapy ACS Applied Materials &Interfaces 10(15) 12960-12974. (2018) (Corres Auth) (if=8.1, ci=02)

421

NAMPERUMALSAMY, VENKATESH PRAJNA (b 1966), Chief, Department of Cornea and Refractive Surgery, Aravind Eye Hospital, Madurai


Dr. N.Venkatesh Prajna combines busy clinical practice and laboratory research effectively. He conducted a randomized control study called as the Madurai Intraocular Lens Study involving 3400 patients that established the superiority of the technique of intraocular lens implantation (IOL) compared to simple intracapsular cataract extraction. This study published in American Journal of Ophthalmology, as a three part series, paved the way for large scale IOL implantations in developing countries. His contributions to the study of mycotic and bacterial keratitis is extensive. He was the Prinicpal Investigator in Mycotic Ulcer treatment trial (MUTT), which established the fact that different fungi respond to different antifungals and the results of this study altered the preferred practice pattern in the treatment of fungal keratitis even in developed countries. His basic research interest is in the areas of tear and corneal proteomics, immunology of corneal infections and in vivo confocal microscopy of limbal stem cells. His involvement and critical input led to framing new probing questions to explore additional problems. He complements the basic researchers and expands their approach to complex clinical problems. He has publications in several international journals such as American Journal of Ophthalmology, British Journal of Ophthalmology, JAMA and Nature Genetics. He is also a peer reviewer of several prestigious journals such as American Journal of Ophthalmology. Apart from all these he is an excellent teacher and mentor of young clinicians and researchers alike.

Proposer: Prof. K.Dharmalingam, Seconder: Prof. G.Marimuthu


1. Prajna NV, Chandrakanth KS, Kim R, Narendran V, Selvakumar S, Rohini G, Manoharan N, et al. (1998) The Madurai Intraocular Lens Study II: clinical outcomes. Am J Ophthalmol. ;125:14-25 (if=3.833, ci=106)

2. Prajna NV, Ellwein LB, Selvaraj S, Manjula K, Kupfer C. ( 2000) The Madurai Intraocular Lens Study IV: posterior capsule opacification. Am J Ophthalmol;130:304-309 (if=3.833, ci=44)

3. Prajna NV, Venkataswamy G. (2001).Cataract Blindness - the Indian Experience. Bull World Health Organ.;79:259-260 (if=5.302, ci=7)

4. Prajna NV, John RK, Nirmalan PK, Lalitha P, Srinivasan M. A (2003).Randomised Clinical Trial Comparing 2 Percentage Econazole and 5 Percentage Natamycin for the Treatment of Fungal Keratitis. Br J Ophthalmol.;87:1235-1237 (if=2.917, ci=41)

5. Prajna NV, Nirmalan PK, Mahalakshmi R, Lalitha P, Srinivasan M. (2004).Concurrent Use of 5 Percentage Natamycin and 2 Percentage Econazole for the Management of Fungal Keratitis. Cornea.;23:793-796. (if=2.106, ci=21)

6. Lalitha P, Prajna NV, Kabra A, Mahadevan K, Srinivasan M. (2006) Risk factors for treatment outcome in fungal keratitis. Ophthalmology. Apr;113(4):526-30. (if=4.825, ci=74)

7. Prajna VN, Nirmalan PK, Saravanan S, Srinivasan M. (2007). Economic Analysis of Corneal Ulcers in South India.Cornea.;26:119-122. (if=2.106 , ci=9)

8. Prajna NV, Krishnan T, Mascarenhas J, Rajaraman R, Prajna L, Srinivasan M,et al. (2013) The Mycotic Ulcer Treatment Trial: a randomized trial comparing natamycin vs voriconazole. JAMA Ophthalmol. ; 131:422-429. (if=2.106 , ci=20)

9. Prajna NV, Srinivasan M, Lalitha P, Krishnan T, Rajaraman R, Ravindran M, et al. (2013). Differences in Clinical Outcomes in Keratitis Due to Fungus and Bacteria. JAMA Ophthalmol. ; 131:1088-1089. (if=2.106 , ci=8)

10. Uddaraju M, Mascarenhas J, Das MR, Radhakrishnan N, Keenan JD, Prajna L, Prajna VN. (2015).Corneal Cross-Linking as an Adjuvant Therapy in the Management of Recalcitrant Deep Stromal Fungal Keratitis: a randomized trial. Am J Ophthalmol.; 160:131-134. (if=3.871 , ci=2)

422

PAUL, JAISHREE (b 1952), Scientist 'C' (Professor); School of Life Sciences, Jawaharlal Nehru University,New Delhi


Her research is focused on two areas : (A). Interplay between the genetic and microbial factors in the pathogenesis of Inflammatory Bowel disease (Ulcerative colitis) in North Indian population. Association of SNPs in susceptible genes like Nucleotide Oligomerization Domain and Toll Like Receptors were evaluated in UC patients of Northern India for the first time. Functional analysis of these SNPs showed their impact on the altered immune response assessed by Real Time analysis of clinical samples. Regulation of miRNA in the pathogenesis of UC revealed site specific expression of miRNA during UC, modulating the expression of target genes. Enumeration of gut bacteria in UC patients targeting specific region of rDNA, revealed significant fluctuations in the concentration of predominant and subdominant species with concomitant change in concentration of their metabolites like SCFA. (B). Enteric Parasites Highthroughput molecular screening technique has been established for the detection and screening of enteric parasites like Entamoeba, Cryptosporidium and Giardia in clinical samples from different geographical locations. Clinical isolates exhibiting varying response to antiamoebic drugs are observed. Fluctuations in the gut flora in amoebic patients were enumerated. To correlate with the virulence of the parasite, characterization of clinical isolates been carried out using few loci of LINE and SINE repeat elements present abundantly in the genome of Entamoeba. Several loci with extensive polymorphism of SINE occupancy among different strains of E. histolytica proved the principle that the genomic distribution of SINEs is a valid method for typing of E. histolytica strains.

Proposer: Prof. Kasturi Datta, Seconder: Prof. Sudha Bhattacharya


1. Nath J, N Banyal, DS Gautam, SK Ghosh, B Singha, Jaishree Paul (2015) Systematic detection and association of Entamoeba species in stool samples from selected sites in India. Epidemiology and infection 143 (01), 108-119. (if=2.365, ci=4)

2. Kumari R, V Ahuja, Jaishree Paul (2013) Fluctuations in butyrate-producing bacteria in ulcerative colitis patients of North India. World J Gastroenterol 19 (22), 3404-3414 (if=2.547, ci=19)

3. Ranjha R, Jaishree Paul ( 2013) Micro-RNAs in inflammatory diseases and as a link between inflammation and cancer Inflammation Research 62 (4), 343-355 (if=2.15, ci=18)

4. Kumari V, Iyer LR, Roy R, Bhargava V, Panda S, Jaishree Paul, Verweij JJ, Clark CG, Bhattacharya A, Bhattacharya S (2013) Genomic distribution of SINEs in Entamoeba histolytica strains: implication for genotyping. BMC genomics 14:432 (if=4.39, ci=4)

5. Verma AK, R Verma, V Ahuja, Jaishree Paul (2012) Real-time analysis of gut flora in Entamoeba histolytica infected patients of Northern India. BMC Microbiology 12 (1), 183 (if=2.73, ci=14)

6. Verma R, V Ahuja, Jaishree Paul (2009) Frequency of single nucleotide polymorphisms in NOD1 gene of ulcerative colitis patients: a case-control study in the Indian population. BMC Medical genetics 10:82 (if=2.536, ci=10)

7. Verma R, Verma A.K., Ahuja V and Jaishree Paul (2010) Real-Time Analysis of Mucosal Flora in Patients with Inflammatory Bowel Disease in India. Journal of Clinical Microbiol. 48: 4279–4282 (if=4.23, ci=45)

8. Rani R, RS Murthy, S Bhattacharya, V Ahuja, MA Rizvi, Jaishree Paul (2006) Changes in bacterial profile during amebiasis: demonstration of anaerobic bacteria in ALA pus samples. The American journal of Tropical Medicine and Hygiene 75 (5), 880-885(if=2.699, ci=11)

9. Srivastava S, S Bhattacharya, Jaishree Paul (2005) Species-and strain-specific probes derived from repetitive DNA for distinguishing Entamoeba histolytica and Entamoeba dispar. Experimental Parasitology 110 (3), 303-308 (if=1.64, ci=27)

10. Azam A, Jaishree Paul, D Sehgal, J Prasad, S Bhattacharya, A Bhattacharya (1996) Identification of novel genes from Entamoeba histolytica by expressed sequence tag analysis. Gene 181 (1), 113-116 (if=2.07, ci=33)

423

SADAKSHARAM, JAYACHANDRAN (b 1964), Professor and HOD, Department of Oral Medicine and Radiology, Tamilnadu Govt. Dental College and Hospital, Chennai 600003


He has contributed significantly in the field of Oral medicine and radiology he did various research in the field of oral cancer to diagnose using Tissue Auto fluorescence, diffuse reflectance, and Raman spectroscopy non - invasively at an earlier stage. He studied using body fluids like saliva and serum for the diagnosis of oral squamous cell carcinoma like salivary interleukins levels,serum nitric oxide and superoxide dismutase significance in cancer and oral sub mucous fibrosis. Studied about the Colour Doppler USG in the evaluation of metastatic lymph node. He conducted clinical trials and treatment modalities for oral and maxillofacial lesions like Pentoxifylline treatment for Oral Sub mucous fibrosis, Bromhexine therapy in rheumatoid arthritis patients, Low intensity Laser therapy for Lichen Planus, Honey and Benzydamine Hydrochloride therapy In radiation Mucositis and Photodynamic therapy in treatment of Oral Lichen Planus and Oral Leukoplakia. He has conducted epidemiological research about the significance of oral lesions in studies on Oral Cancer and also the prevalence of common dental anomalies.He has also carried out identification of oral lesions in HIV in ART vs. pre-ART patients and formulated dental considerations for HIV patients. Currently he is working on the application of Cone Beam Computed Tomography in diagnosis of oral and maxillofacial conditions. He is interested in forensic dentistry and researched about the age estimation with dentin translucency using Raman Spectroscopy. I have both national and international publications. He has authored books such as oral cancer prevention and oral health on overall health to create awareness to society.

Proposer: Dr. Mohan V, Seconder: Dr. M. Michael Aruldhas


1. Sadaksharam J, Mahalingam S. 2017. Evaluation of Oral Pentoxifylline in the Management of Oral Submucous Fibrosis – An Ultrasonographic Study. Contemporary Clinical Dentistry. ;8 (2):200-204. (if=1.652, ci=1)

2. Sadaksharam J, M preethi.(2017) Multidisciplinary Clinical Management of Paraneoplastic Pemphigus – A Case Report. J ClinDiagn Res. Oct, Vol-11(10): ZD01-ZD032 (if=0.65, ci=1)

3. Sadaksharam J, Khobre P.(2017) Efficacy of Bromelain along with Trypsin, RutosideTrihydrate Enzymes and Diclofenac Sodium Combination Therapy for the treatment of TMJ Osteoarthritis - A Randomised Clinical Trial . J ClinDiagn Res. Jun;11(6):ZC09-ZC11(if=0.65, ci=2)

4. Jayachandran S, Meenapriya PK, GanesanS(2016). Raman spectroscopic analysis of blood, Urine, saliva and Tissue of oral potentially Malignant Disorders and Malignancy-a Diagnostic study. Int J Oral CraniofacSci2(1):011-014. (if=1, ci=4)

5. Jayachandran, S., & Kumar, M. S. (2016). A paradoxical presentation of rickets and secondary osteomyelitis of the jaw in Type II autosomal dominant osteopetrosis: Rare case reports. Indian Journal of Dental Research, 27(6), 667. (if=24, ci=3)

6. PanneerSelvam, N. and Sadaksharam, J. (2015), Salivary interleukin-6 in the detection of oral cancer and precancer. Asia-Pacific Journal of Clinical Oncology, 11: 236–241. (if=1.494, ci=15)

7. Jayachandran, S., &Balaji, N. (2012). Evaluating the effectiveness of topical application of natural honey and benzydamine hydrochloride in the management of radiation mucositis.Indian Journal of Palliative Care, 18(3), 190–195 (if=0.708, ci=30)

8. Jayachandran S, SachdevaSK(2012). Diagnostic accuracy of color Doppler ultrasonography in evaluation of cervical lymphnode in oral cancer patients. Indian J Dent Res;23:557-8 (if=20, ci=2)

9. Sadaksharam J., Nayaki, K. P. T. and PanneerSelvam, N. (2012), Treatment of oral lichen planus with methylene blue mediated photodynamic therapy – a clinical study. Photodermatology, Photoimmunology&Photomedicine, 28: 97–101 (if=1.516, ci=35)

10. Jayachandran, S., &Krithika, C. (2006). Mucormycosis presenting as palatal perforation .References.Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research, 17(3), 139–42 (if=20, ci=36)

424

SOUNDARAPANDIAN, KANNAN (b 1972), Department of Zoology, Periyar University, Salem-636011


Dr. S. K research group contributes in development of enhanced smart gene / drug delivery system to target cancers which is appreciable. The preliminary study has mainly focused on development of therapeutic agents for lung and breast colon, cervical cancers, with enzyme targets, namely cytosolic phospholipase A2α (cPLA2α) and Cyclooxygenase (potential cancer biomarkers). Later the enzyme-targeted prodrugs namely Phytochemicals and cancer antibiotics are significantly loaded into metal nanoparticles for antibody mediated drug delivery in cancer cells. The main objective of our lab is to target cancer at proteomic and sub-cellular level. In this context, our team rigorously investigates the impact of nano-formulated drugs/gene or siRNA on cell cycle, cell proliferation and cell viability with special attention on cell organelles like endoplasmic reticulum, mitochondria, nucleus etc. Our recent attempts not only looking for the best nano-cores for drug delivery to target cancers but also exploit our expertise to develop theranostic agents to kill even drug resistant cancers like Triple Negative breast cancer. Prof. Kannan’s research also focusing on development of biomaterials to induce anti-inflammatory response during wound healing by converting M1 macrophages into M2 macrophages with the support of interleukins (IL1 alpha, IL4 and IL10) and growth factors etc. His biomedical engineering work would support him to develop organ on chip (He had research training at Harvard Medical School, USA). The method described for nanomaterial synthesis is cited in Sigma catalog book.

Proposer: Prof. Pillai Madhavan Radhakrishna, Seconder: Prof. G. Marimuthu


1. R.Vivek, R. Thangam, K. Muthuchelian, P.Gunasekaran, K. Kaveri and S. Kannan 2012. Green biosynthesis of silver nanoparticles from Annona squamosa leaf extract and its in vitro cytotoxic effect on MCF-7 cells. Process Biochem., 2012: 47: 2405–2410 (if=2.53, ci=198)

2. R. Vivek, R. Thangam, S. Rajesh kumar, C. Rejeeth, G. Senthil Kumar, S. Sivasubramanian, S. Vincent, D.Gopi, S.Kannan. 2016. Multifunctional Magnetite Polymer Therapeutic Nanocomposites with “Off-On” Mechanism for Efficient and Selective HER2 Targeted Cancer Therapy. ACS Applied Materials & Interfaces. 8(3):2262-79. (if=8.097, ci=74)

3. K Vimala, S Sundarraj, M Paulpandi, S Vengatesan, S Kannan. 2014. Green synthesized doxorubicin loaded zinc oxide nanoparticles regulates the Bax and Bcl-2 expression in breast and colon carcinoma. Process Biochemistry 49 (1), 160-172 (if=2.53, ci=75)

4. MV. Sujitha and S. Kannan 2013. Green synthesis of gold nanoparticles using Citrus fruits aqueous extract and its characterization. Spectrochemica Acta Part A: Molecular and Biomolecular Spectroscopy. 102: 15-23. (if=2.91, ci=155)

5. Carlos Barrios-Estrada, Magdalena de Jesús Rostro-Alanis, Blanca Delia Muñoz-Gutiérrez, Hafiz MN Iqbal, S. Kannan, Roberto Parra-Saldivar. 2018. Emergent contaminants: endocrine disruptors and their laccase-assisted degradation–a review. Science of the Total Environment. 612: 1516-1531 (if=4.91, ci=40)

6. Ramya S. E.Shinyjoy, Kavitha Louis, S. Kannan, and D. Gopi. 2016. Fabrication of minerals substituted porous hydroxyapaptite/Poly (3,4-ethylenedioxy pyrrole-co-3,4 ethylene di oxythiophene) bilayer coatings on surgical grade stainless steel and biological activities for orthopedic applications. ACS Applied Materials & Interfaces. 8(19):12404- (if=8.097, ci=43)

7. R Thangam, V Suresh, W Asenath Princy, M Rajkumar, N Senthilkumar, P Gunasekaran, R Rengasamy, C Anbazhagan, K Kaveri, S Kannan. 2013. C-Phycocyanin from Oscillatoria tenuis exhibited an antioxidant and in vitro antiproliferative activity through induction of apoptosis and G0/G1 cell cycle arrest. Food Chem., 140(1-2):262-272 (if=3.921, ci=73)

8. N. Kanipandian, S.Kannan, R. Ramesh, P. Subramanian, R. Thirumurugan 2014. Characterization, antioxidant and cytotoxicity evaluation of green synthesized silver nanoparticles using Cleistanthus collinus extract as surface modifier, Materials Research Bulletin 49: 494-502 (if=2.54, ci=71)

9. R.Thangam, M.Sathuvan, A.Poongodi, V.Suresh, K.Pazhanichamy, S. Sivasubramanian, N. Kanipandian, N.Ganesan, R.Rengasamy, R.Thirumurugan, S.Kannan 2014. Activation of intrinsic apoptotic signaling pathway in cancer cells by Cymbopogon citratus polysaccharide fractions. Carbohydrate Polymers 107:138-150. (if=5.158, ci=51)

10. S. Sundarraj, R. Thangam, V.Sreevani, K. Kaveri, P. Gunasekaran, S. Achiraman, S.Kannan 2012. γ-Sitosterol from Acacia nilotica L. induces G2/M cell cycle arrest and apoptosis through c-Myc suppression in MCF-7 and A549 cells. J. Ethanopharacol., 141(3): 803-809.(if=3.055, ci=60)

425

TANDON, SALIL (b 1965), Consultant Urologist,N.E.Railway Hospital, Lucknow, U.P.


THE STRONG EDUCATIONAL BACKGROUND : Dr. Salil Tandon underwent his medical education from the K.G.M.U, Lucknow and was bestowed with Gold Medals & Certificates of honours. He continued his career in England & was awarded Certificate of Urology { Royal College} GMC of England has granted him full registration.He worked as Visiting Fellow in America, U.K. and S.E. Asia. THE UNIQUE LEVEL OF COMMITMENT TO THE STATE : He resigned his job in U.K and returned to Lucknow to serve his people in 2001. He is attached to N.E Railway Hospital, & HAL,Lucknow. MANY FIRSTS TO HIS CREDIT : He is the first Urologist in the resent past, from U.P. to be awarded FRCSI (2015), FACS (Urology 2012) and simultaneously MAMS & FICS (Urology,2010). First Urologist from U.P. who received training in male infertility from Cleveland Clinic, USA and Edinburgh,U.K. and has been able to develop reproductive medicine as a new sub speciality. His academic achievements have been honoured with several awards including U.P.Government “Vigyan Ratan Award” He has also worked in the field of Homeopathic medicine (project sponsored by AYUSH,),and has helped in developing cost effective treatment for prostate and stone disease. CURRENT AREA OF RESEARCH : 1] Effect of life style factors on Reproductive Health, 2] Bariatric Surgery and Male infertility, 3] Incidence of Genetic cause (Karyotype and Y Chromosome Micro deletion) for Male Infertility, 4] Incidence of CBAVD in Indian sub population.

Proposer: Prof.Shally Awasthi, Seconder: Prof. P.Pushpangadan


1. R Donat, S Tandon, KM Grigor, JW Fowler. Neoadjuvant Androgen Blockade (NAB) in T1 and T2 prostate carcinoma. Histology and PSA failure. After Radical Prostatectomy.Accepted in supplement to Prostate cancer and Prostate disease,2000;5

2. R Donat, S Tandon, KM Grigor, JW Fowler. Neoadjuvant Androgen Blockade (NAB) in T1 and T2 prostate carcinoma. Histology and PSA failure. After Radical Prostatectomy – URO ONCOLOGY, 2001,Vol.1,139-145 (if= 2.77 )

3. S Tandon, ES Sabanegh Chronic Pain After Vasectomy (PVPS): A Diagnostic And Treatment Dilemma. BJUI July II 2008,102,no. 2,166-169 (if= 3.13, ci= 44)

4. G Gupta, JP Singh, S Tandon, S Singh, C Nayak, H Singh, Ch.Raveendar, KRJ.Nair, P Oberai. "Evidence based clinical study to assess the usefulness of homeopathic medicines in patients of benign prostatic hyperplasia “Indian Journ

5. Tait C, Tandon S, Sweeney S, Byrne D, Nabi G: Radical treatment for bladder cancer in Tayside: Non-random comparison of surgery versus radiotherapy. Scott Med J 2011, 56:115 (if= 0.55)

6. Tait C, Tandon S, Goodman C, Towenell N, Baker L,Nabi G:Long Term Oncological outcomes of Laparoscopic Radical Nephrectomy for Kidney cancer Resection:Dundee Cohort and Meta-Analysis of Observational studies,Surgical Endoscopy -Epub(if= 3.3, ci= 20)

7. G.Gupta, JP Singh, S Tandon, S Singh, C Nayak, H Singh,et al “Evidence based clinical study of homeopathic medicines in Patients of Benign Prostatic Hyperplasia”Americal Journal of Homeopathic Medicine,Summer 2012,V (ci= 1 )

8. Gupta AK, Tandon S: Interim result on the usefulness of Homeopathic therapy in Urolithiasis-An observational study.Journal of Surgical Sciences,March 2014,Vol 4,Issue 1:19-23

9. Tandon S : Antisperm Antibody in Men-“A Clinical Puzzle”. J.Int. Coll.Surg. Ind.Sec: JICSIS (2017) 1(1):6-11

10. Tandon S: Sperm DNA fragmentation testing: Where we stand in 2017, Transl Androl Urol, 2017,6(suppl 4):S 697-698 (if= 0.57, ci= 1 )

426

BHATTACHARYYA, MAITREE (b 1960), Professor, Department of Biochemistry, Calcutta University and Director, Jagadis Bose National Science Talent Search, Kolkata


Prof. Maitree Bhattacharyya graduated from Presidency College with Honours in Physics and obtained M.Sc from Calcutta University. Started research career in Department of Biophysics and Molecular Biology, CU with PhD in 1991.Now she is Professor, Department of Biochemistry in University of Calcutta. Ten students have already been awarded PhD degree under her supervision and she is leading a group of ten research scholars which comprises of PhD and post doctoral students. Her major research interest is in the field of biomedical research. She worked on the oxidative and nitrosative stresses in thalassemia, arsenic toxicity, diabetes mellitus and in protein drug biomolecular interaction. Her major contribution lies in identifying the risk factors and biomarkers in the disease dynamics of diabetes and associated cardiovascular disease and dyslipidemia. She has also developed a kit for detection of Platelet shed Microparticles (MP) under Flow Cytometry Platform, for which the patent has been filed. This work has got immense significance as a diagnostic tool for prediction of cardiovascular disease in diabetes. She is also working to explore the microbial diversity in the coastal and estuarine area of Sunderban, Chilika and Gujarat. Apart from academic research and teaching she is passionate to develop scientific and technological sphere of India especially the human resource to the level of highest possible International Standard. To fulfill this ambition she has recently joined (on lien) as Director of Jagadis Bose National Science Talent Search, where young talents are nurtured and motivated to achieve the best quality human resource.

Proposer : Prof. Gobardhan Das, Seconder : Prof. Amitabha Mukhopadhyay


1. Dibyendu Chakraborty & Maitree Bhattacharyya (2001), Antioxidant defence status of Red Blood cell in B-thalassemia patient, Clinica Cheimica Acta (Elsevier), 305,123-129 (if=2.748, ci=81)

2. Maitree Bhattacharyya, U. Chaudhuri and R. K. Poddar (1990), Evidence for cooperative binding of chlorpromazine with haemoglobin : Equilibrium dialysis, fluorescence, quenching and oxygen release study, Biochemical Biophysical Research Communications, (Academic Press), 167, 1146-1153. (if=2.474, ci=70)

3. Chakraborty A ,Chowdhury S,Bhattacharyya M. Effect of metformin on oxidative stress, nitrosative stress and inflammatory biomarkers in type 2 diabetes patients. Diabetes research and clinical practice. (Available online 13 December 2010.) Impact factor-2.1(if=2.853, ci=60)

4. J. Bhattacharyya, Maitree Bhattacharyya, A. S. Chakraborty, U. Chaudhuri and R. K. Poddar (1994), Binding of chlorpromazine with hemoglobin and myoglobin: A comparative study -Biochemical Pharmacology (pergamon Press), 11, 2049-2053. (if=4.772, ci=55)

5. Adak S, Chowdhury S and Bhattacharyya M. Dynamic and electrokinetic behavior of erythrocyte membrane in diabetes mellitus and diabetic cardiovascular disease Biochimica et Biophysica Acta (BBA) - General Subjects. (2008) Biochimica et Biophysica Acta ,1780, 108-115 (if=4.554, ci=26)

6. Arindam Saha, Sangeeta Adak, Subhankar Chowdhury, Maitree Bhattacharyya (2005), Enhanced Oxygen releasing capacity and Oxidative stress in Diabetes Mellitus and Diabetes Mellitus Associated Cardiovascular Disease: A comparative study, Clinica Chimica Acta,( Elsevier) 361,141-149 (if=2.748, ci=26)

7. J. Bhattacharyya, M. Bhattacharyya, A. S. Chakrabarty, U. Chaudhuri & R.K. Poddar (1998), Structural organisation of hemoglobin and myoglobin influence their binding behaviour with phenothiazines, International Journal of Biological Macromolecules (Elsevier), 23, 11-18. (if=3.227, ci=23)

8. Dibyendu Chakraborty & Maitree Bhattacharyya (2000), Deferiprone (LI) induced conformation change of Hemoglobin: A fluorescence and CD spectroscopic study, Molecular and Cellular Biochemistry, 204. 17-20. (if=2.388, ci=18)

9. Maitree Bhattacharyya, U. Chaudhuri and R.K.Poddar (1990), Studies on the interaction of chlorpromazine with haemoglobin, International Journal of Biological Macromolecules, (Butterworths) 12, 297-301 (if=3.227, ci=12)

10. Adak S, Sengupta S , Chowdhury S and Bhattacharyya M.Co-existence of risk and protective haplotypes of Calpain 10 gene to type 2 diabetes in the eastern Indian population. Diabetes and Vascular Disease Research. 2010; 7; 63 (if=3.04, ci=11)

427

CHAKRABARTI, SUBHABRATA (b 1972), Associate Director (Research), L.V. Prasad Eye Institute, Hyderabad


Dr. Subhabrata Chakrabarti is one of the leading Human Geneticist of the country with immense contributions in the areas of understanding the molecular mechanisms of complex eye diseases. His major work on functional genomics of primary congenital glaucoma (PCG) that affects children in the developing world, has convincingly demonstrated the role of CYP1B1 (a major candidate gene) and other novel genes in the disease pathogenesis. He also provided evolutionary insights on the geographical structuring and migrations of these disease-associated mutations worldwide. This led to the initiation of bilateral grants with Brazil, Tunisia, Portugal, and Australia to understand the nature-nurture dialectics in PCG. The dissection of the genetic and physical interactions of genes and genotype-phenotype correlations in PCG have provided clues for undertaking predictive testing. Further, his work on genomics of age-related and rare eye diseases in the populations have an overarching component of translation from bench to bedside. He has published widely in reputed journals and has been well funded with national and international grants. Dr. Chakrabarti's work has also provided him international recognition in the form of several honors and awards; notable among them being the 'Research Recognition Award' of the World Glaucoma Association (WGA) and as Affiliate of all the 3 Science Academies of India (INSA, NASI and IASc) and also The World Academy of Sciences (TWAS). He is an internationally acclaimed scientist and serves on various editorial boards, international funding agencies and scientific bodies on eye research.

Proposer: Prof. Partha P Majumder, Seconder: Prof. D. Balasubramanian


1. Kabra M, ..........Chakrabarti S*. (2017) Angiopoietin receptor TEK interacts with CYP1B1 in primary congenital glaucoma. Hum Genet; 136: 941-949. (if=4.637, ci=0)

2. Rathi S, ..........Chakrabarti S, Kaur I. (2017) Aberrant microglia-mediated complement activation and inflammation in the pathogenesis of retinopathy of prematurity. Front Immunol; 8: 1868. (if=6.429, ci=0)

3. de Melo MB, ............Chakrabarti S*. (2015) Genotype-phenotype correlations in CYP1B1-associated primary congenital glaucoma patients representing two large cohorts from India and Brazil. PLoS One; 10: e0127147 (if=2.806, ci=8)

4. Thakkinstian A, McEvoy M, Chakravarthy U, Chakrabarti S, et al. (2012) The Association Between Complement Component 2/Complement Factor B Polymorphisms and Age-Related Macular Degeneration: A HuGE Review and Meta-Analysis. Am J Epidemiol; 176: 361-37 (if=4.825, ci=47)

5. Chakrabarti S*, ..........Majumder PP. (2010) A polymorphism in the CYP1B1 promoter is functionally associated with primary congenital glaucoma. Hum Mol Genet; 19: 4083-4090. (if=3.303, ci=20)

6. Kaur I, Rathi S, Chakrabarti S*. (2010) Variations in TIMP3 are associated with age-related macular degeneration. Proc Natl Acad Sci, USA; 107: E112-113 (if=9.661, ci=9)

7. Kaur I, ......... Chakrabarti S*. (2008) Variants in the 10q26 gene cluster (LOC387715 and HTRA1) exhibit enhanced risk of age-related macular degeneration along with CFH in Indian patients. Invest Ophthalmol Vis Sci; 49: 1771-1776. (if=3.303, ci=69)

8. Kaur I, ............ Chakrabarti S*. (2006) Analysis of CFH, TLR4 and APOE polymorphisms in India suggests the Tyr402His variant of CFH to be a global marker for age-related macular degeneration. Invest Ophthalmol Vis Sci; 47: 3729-3735. (if=3.303, ci=83)

9. Chakrabarti S*, .......... Majumder PP. (2006) Globally, CYP1B1 mutations in primary congenital glaucoma are strongly structured by geographic and haplotype backgrounds. Invest Ophthalmol Vis Sci; 47: 43-47. (if=3.303, ci=51)

10. Kaur K, ......... Chakrabarti S*. (2005) Myocilin gene implicated in primary congenital glaucoma. Clin Genet; 67: 335-340. (if=3.326, ci=72)

428

CHANDAK, GIRIRAJ RATAN (b 1963),Sr. Principal Scientist and Group Leader, CSIR-Centre for Cellular and Molecular Biology, Hyderabad


The outstanding contribution of Dr G R Chandak demonstrating the genetic and mutational heterogeneity and gene-nutrient interaction in prevalent complex diseases, such as chronic pancreatitis, diabetes mellitus, neural tube defects, etc. in Indians can be seen from his regular contribution in journals of Nature group including Nature and Nature Genetics. He has identified two novel genes, SPINK1 and CTSB that predict susceptibility to chronic pancreatitis in Indians, which established genetic basis of tropical calcific pancreatitis and inclusion in the Online Mendelian Inheritance in Man (MIM#608819) and are being used for genetic testing of chronic pancreatitis. He has been the first to show that genetic susceptibility to type 2 diabetes in Indians is different than Europeans, especially for traits like central obesity and insulin resistance. He has established the causal role of maternal B12 deficiency and one-carbon metabolism in predicting low birth weight and adiposity in their children. Using animal models of B12 deficiency, he has demonstrated altered PPAR signalling pathway in explaining fetal programming of obesity, insulin resistance and altered lipid metabolism. His studies provide a possible link of differential epigenetic regulation of candidate type 2 diabetes genes with B12 deficiency that is widely prevalent in the Indians. In contrast to the globally established role of folate deficiency, his studies have conclusively established a major role for maternal B12 deficiency in the risk of neural tube defects. He has also created awareness about preventing monogenic genetic disorders by prenatal diagnosis and genetic counselling using cost-effective protocols.

Proposer: Dr. Ch. Mohan Rao, Seconder: Dr. R. Sankaranarayanan


1. Georg B. Ehret, Patricia B. Munroe, Kenneth M. Rice, Murielle Bochud, ICBP-GWAS Consortium, G R Chandak et al. (2011). Genetic variants in novel pathways influence blood pressure and cardiovascular risk. Nature, 478(7367): 103-9. (if=36.280, ci=1306)

2. P D Gluckman, P Bateson, A S Beedle, Z A Bhutta, M A Hanson, C Law, K V Anokhin, P Bougnères, G R Chandak, P Dasupta, G D Smith, P T Ellison, T Forrester, S F Gilbert, E Jablonka, H Kaplan, A M Prentice, S J Simpson, R Uauy & M J West-Eberhard (20 (if=30.758, ci=332)

3. G R Chandak, C S Janipalli, S Bhaskar, S R Kulkarni, P Mohankrishna, A T Hattersley, T M Frayling, C S Yajnik (2007). Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population. Diabetologia 5 (if=6.227, ci=257)

4. G R Chandak, M Mohd Idris, D Nageshwar Reddy, S Bhaskar, PVJ Sriram and L Singh (2002). “Mutations in Pancreatic Secretory Trypsin Inhibitor (PSTI/SPINK1) rather than Cationic Trypsinogen Gene (PRSS1) are Significantly Associated with Tropical Cal (if=7.774, ci=179)

5. C S Yajnik, C S Janipalli, S Bhaskar, S R Kulkarni, R M Freathy, S Prakash, K R Mani, M N Weedon,, S D Kale, J Deshpande, G V Krishnaveni, S R Veena, C H D Fall, M I McCarthy, T M Frayling, A T Hattersley, G R Chandak (2009). “FTO Gene Variants a (if=6.227, ci=174)

6. Heiko Witt, Sebastian Beer, Jonas Rosendahl, Jian-Min Chen, G R Chandak, et al. Loss-of-function mutations in CPA1 are strongly associated with early-onset chronic pancreatitis. Nature Genetics. 2013 Oct;45(10):1216-20. doi: 10.1038/ng.2730. Epub (if=29.648, ci=140)

7. Ganesh Chauhan, Charles J Spurgeon, 12 more authors and G R Chandak (2010). Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC3018, HHEX, CDKN2A, IGF2BP2 AND CDKAL1 on the risk of type 2 diabetes in 5148 Indians. Diabetes ;59(8):2068-74. (if=8.889, ci=148)

8. Swapna Mahurkar, M Mohd Idris, D Nageshwar Reddy, S Bhaskar, G V Rao, V Thomas, Lalji Singh, G R Chandak (2006). Association of Cathepsin B Polymorphisms with Tropical Calcific Pancreatitis. Gut 55: 1270-1275. (if=10.111, ci=84)

9. G R Chandak, M Mohd Idris, D Nageshwar Reddy, K Radha Mani, S Bhaskar, G V Rao and L Singh (2004). “Absence of PRSS1 Mutations and Association of SPINK1 Trypsin Inhibitor Mutations in Hereditary and Non-Hereditary Chronic Pancreatitis”. Gut; 53(5) (if=10.111, ci=104)

10. C Fuchsberger, J Flannick, TM Teslovich, A Mahajan, V Agarwala, several authors, G R Chandak (2016). "The genetic architecture of type 2 diabetes". Nature 536 (7614), 41. (if=36.280, ci=262)

429

CHATTOPADHYAY, DEBPRASAD (b 1959), Scientist G & Director, ICMR-National Institute of Traditional Medicine, Belagavi Member of the NASI: No (YON 2015, Medical & Forensic Sciences) Dr. Chattopadhyay has exceedingly contributed in the field of Ethnomedicine, towards drug discovery against emerging, re-emerging and difficult to treat diseases. Finding new therapies from an untapped natural resource is the need of the hour. His group has validated herbs, herbal preparations/ formulas used in traditional practices of diverse Indian tribes including Onge, Nicobarese, Shompen, Birhore, Kattabhai, Santal etc, and identified molecules with pharmacological potentials such as anti-inflammatory, antibacterial, antiviral, contraceptive drugs. His group has also revealed the mechanism of action of these agents. The most notable one is the isolation and identification of an anti-HSV alkaloid. The mechanistic study showed that it inhibits the immediate early transcription of HSV in-vitro and in-vivo. The same approach helped to find new principles for typhoid and tuberculosis. His ground breaking work with an existing drug demonstrate alters the membrane permeability of drug-resistant bacteria, a hope to the management of microbial drug-resistant problem. In addition Dr Chattopadhyay significantly contributed in contraception research, another challenging area most relevant to India. Contraception without side effect is highly desirable. His group has identified a phenolic having potent sperm motility inhibiting activity from a preparation used by Onge. Altogether his ethnomedicinal approach is unique and highly successful in settling the principles of the management of HSV,typhoid, contraception and wound healing. India has vast resources of ethnomedicinal plants, and Dr Chattopadhyay has disseminated to common people. Therefore, the awareness to use herbal formulation from the age-old practices is led and fostered by him.

Proposer: Dr. Bhaskar Saha, Seconder: Prof. Subrata Majumder Ten Best Publications: 1. Chattopadhyay D, Mukherjee T, Pal P, Saha B, Bhadra R (1998). Altered membrane permeability as the basis of bactericidal action of methdilazine. J Antimicrobial Chemotherapy 42: 83-85 (if=5.439, ci=43) 2. Chattopadhyay D, Maiti K, Kundu AP, Chakrabarty MS, Bhadra R, Mandal SC, Mandal AB (2001). Antimicrobial activity of Alstonia macrophylla: folklore of Bay Islands. Journal of Ethnopharmacology 77: 49-55 (if=3.055, ci=93) 3. Chattopadhyay D, Arunachalam G, Mandal AB, Sur Tapas K, Mandal SC, Bhattacharya SK (2002). Antimicrobial and anti-inflammatory activity of Mallotus peltatus leaf extract. Journal of Ethnopharmacology 82(2-3): 229-237 (if=3.055, ci=177) 4. Arunachalam G, Chattopadhyay D, Chatterjee S, Mandal AB, Sur TK, Mandal SC (2002). Evaluation of anti-inflammatory activity of Alstonia macrophylla Wall ex A. DC. Leaf extract. Phytomedicine 9(7): 632-635 (if=3.268, ci=38) 5. Chattopadhyay D, Arunachalam G, Mandal AB, Bhadra R, Mandal SC (2003). CNS activity of Mallotus peltatus Muell Arg. Leaf extracts: An ethnomedicine of Bay Islands. Journal of Ethnopharmacology 85(1): 99-105 (if=3.055, ci=40) 6. Chattopadhyay D, Arunachalam G, Bhadra R, Ghosh L, Mandal AB (2004). CNS activity of the leaf extracts of Alstonia macrophylla Wall ex A. DC: An Ethnomedicine of Bay Islands. Fitoterapia 75(7-8): 673-682. (if=2.408, ci=66) 7. Chattopadhyay D, Arunachalam G, Mandal SC, Ghosh L, Rajendran K, Mandal AB, Bhattacharya SK (2005). Antipyretic activity of leaf extract of Alstonia macrophylla Wall ex A. DC: An ethnomedicine of Andaman Islands. J Pharmacy & Pharmaceutical Sciences (if=2.85, ci=82) 8. Chattopadhyay D, Dungdung SR, Majumder GC, Bhattacharya SK, Mandal AB (2005). A potent sperm motility inhibiting bioflavonoids from an Ethnomedicine of Onge, Alstonia macrophylla Wall ex A. DC. Leaf extract. Contraception 71(5):372-378 (if=3.09, ci=29) 9. Ghosh S, Samanta A, Mandal NB, Banerjee S, Chattopadhyay D (2012). Evaluation of wound healing activity of methanolic extract of Pedilanthus tithymaloides (L.) Poit leaf and its isolated active constituents in topical formulation. Journal of Ethnopha (if=3.055, ci=25) 10. Bag P, Ojha D, Mukherjee H, Halder UC, Mondal S, Nandi S, Sharon A, Chakrabarti S, Chattopadhyay D (2013). An indole alkaloid from a Tribal folklore inhibits immediate early event in HSV-2 infected cells with therapeutic efficacy in vaginally infecte (if=3.534, ci=20)

430

COLAH, ROSHAN BEHRAM (b 1952) Former Scientist G & Director-in-Charge, National Institute of Immunohaematology, (ICMR), Mumbai.


Dr Roshan Colah is a researcher of international standing and repute. Over last 35 or more years she has been a beacon of research on haemoglobinopathies and red cell enzymopathies in this country. In more than 250 of her research paper one can she her evolution from a student researcher to an erudite scientist. Most of these papers have been published in high impact international journals. She developed a new technique for prenatal diagnosis of haemoglobinopathies. Her technique of reverse covalent dot blot hybridization of common haemoglobinopathy mutation in India is a patented technique.She established a comprehensive prenatal diagnosis centre in NIIh where she worked. Herresearch on hydroxyurea in thalassaemia, hydroxy urea as an iron chelator etc got critical national acclaim. Her work on molecular pathology and epistatic interaction of haemoglobinopathy in modulating its clinical presentation constitute a substantial bulk of her research work. At present very few laboratory in India investigates red cell enzymopathy comprehensively and the only one such comprehensive laboratory was established by her at NIIH, Mumbai. Dr Coalh is a member in many national and international committees. She has written several chapters in quite a few books and edited herself 3 books for every day use by haemoglobinopathy research. In fact to day in India nobody stands as tall as her in haemoglobinopathy research. She deserved this fellowship long time back I strongly endorse her fellowship in the academy without any further delay.

Proposer: Prof. Kanjaksha Ghosh, Seconder: Dr. Smita D. Mahale Ten Best Publications: 1. Sukumar Sridevi, Colah, Roshan, Mohanty Dipika. (2002) G6PD gene mutations in India producing drug -inducing hemolytic anemia. Br. J.Haematol 116:671-672 (if=4.72; ci=24) 2. D’Souza E, Sawant P, Nadkarni A, Gorakshakar A, Mohanty D, Ghosh K, Colah R. (2008) Evaluation of the use of monoclonal antibodies and nested PCR for non-invasive prenatal diagnosis of hemolobinopatheis in India. Am J. Clin Pathol. 130(2):202-9. (If=2.89; ci=11) 3. Colah R, Gorakshakar A, Nadkarni A, Phanasgaonkar S, Surve R, Sawant P, Mohanty D, Ghosh K. (2009) Regional heterogeneity of beta thalassemia mutations in the multi ethnic Indian population Blood Cells Mol Dis.; 42(3):241-6. (If=2.549; ci= 38) 4. Khushnooma Y Italia, Farah Jijina, Rashid Merchant, Sangeeta Panjwani, Anita H Nadkarni, Pratibha M Sawant, Sona B Nair, Kanjaksha Ghosh Roshan B Colah (2009). Response to hydroxyurea in beta-thalassemia major and intermedia: Experience in western India. Clin Chim. Acta. 407; 10-15. (If=2.960; ci= 51) 5. Italia K, Jain D, Gattani S, Jijina F, Nadkarni A, Sawant P, Nair S, Mohanty D, Ghosh K, Colah R. (2009) Hydroxyurea in sickle cell disease – a study of clinico – pharamacological efficacy in the Indian haplotype. Blood Cells Mol Dis. 42(1):25-31. (if= 2.549, ci= 51) 6. Colah R, Gorakshakar A, Phanasgaonkar S, D'Souza E, Nadkarni A, Surve R, Sawant P, Master D, Patel R, Ghosh K, Mohanty D. (2010) Epidemiology of beta – thalassemia in West ern India: mapping the frequencies and mutations in sub – regions of Maharashtra and Gujarat. Br J Haematol. 149; 739 – 47. (If= 4.942, ci= 36) 7. Colah R, Mukherjee M, Ghosh K. (2014) Sickle cell disease in India. Curr Opin Hematol; 21(3):215-23. (If=4.11, ci= 18) 8. Warang PP, Kedar PS, Shanmukaiah C, Ghosh K, Colah RB. (2015) Clinical spectrum and molecular basis of recessive congenital methemoglobinemia in India.Clin Genet. 87(1):62-7. (If= 3.89; ci= 9) 9. Italia K, Kangne H, Shanmukaiah C, Nadkarni AH, Ghosh K, Colah RB. (2015) Variable phenotypes of sickle cell disease in India with the Arab-Indian haplotype. Br J Haematol. 2015; 168(1):156-9 (if= 5.4; ci= 7) 10. Upadhye DS, Jain DL, Trivedi YL, Nadkarni AH, Ghosh K, Colah RB.(2016) Neonatal Screening and the Clinical Outcome in Children with Sickle Cell Disease in Central India. PLoS One. 11(1):e0147081. (If= 4.41; ci= 4)

http://www.ncbi.nlm.nih.gov/pubmed/24266649


https://www.ncbi.nlm.nih.gov/pubmed/25135424

https://www.ncbi.nlm.nih.gov/pubmed/25135424



431

DAS, SATYA NARAYAN (b 1952), Professor, Department of Biotechnology, AIIMS, New Delhi


Dr. Das has made significant contribution in cancer research specially in understanding the genetic susceptibility to breast (Valarmathi et al, 2003, 2004) and oral cancer (Jha et al, 2013; Karimi et al, 2013; Bharti et al, 2013; Gaur et al, 2011a, 2011b; Mittal et al, 2010; Gupta et al, 2008). In case with familial breast cancer his group detected about 20 novel mutations in BRCA1 and BRCA 2 gene while in oral cancer novel polymorphisms were reported in hMLH1 gene, TNF-alpha and TNF receptor genes, COX-2, TGF-beta, IL-4 and IL-6 genes and CTLA-4 genes that may be useful to screen population at a higher risk. Dr. Das was first to report abnormal expression of PI3K isoforms (Garg et al, 2013) and COX-2 (Kapoor et al, 2010) in oral cancer patients and showed that peptide inhibitors of COX-2 significantly inhibited tumour cell growth and proliferation. These findings may lead to development of peptide/biological inhibitors of PI3K and COX-2 for chemopreventive and chemotherapeutic strategy for oral cancer. Recently his group showed impaired population and functions of invariant Natural Killer T (iNKT) cell subsets in oral cancer patients (Singh et al, 2013, 2015). They further showed that selective activation of iNKT cells by its ligand along with tumour antigen via dendritic cells significantly reduced tumour cell viability and enhanced apoptosis. These observations will provide an efficient process of NKT cell-based vaccination of oral cancer patients in order to prevent development and recurrence of the tumours.

Proposer : Prof. Y. D. Sharma, Seconder : Prof. J. S. Tyagi


1. Valarmathi MT, Agarwal A, Deo SVS, Shukla NK, Das SN (2003) BRCA1 germline mutations in Indian familial breast cancer. Hum Mutat. 21(1): 98-99. (On-line). (if=7.033)

2. Valarmathi MT, Sawhney M, Deo SVS, Shukla NK, Das SN (2004). Novel germline mutations in BRCA1 and BRCA2 genes in Indian breast and breast-ovarian cancer families. Hum Mutat. 23(2): 205. (on-line). (if=7.033)

3. Manchanda P, Sharma SC, Das SN. (2006) Differential regulation of IL-2 and IL-4 in patients with tobacco related oral squamous cell carcinoma. Oral Dis. 12: 455-462. (if=2.145)

4. Gupta R, Sharma SC and Das SN (2008): Association of TNF-α and TNFR1 promoters and 3’ UTR region of TNFR2 gene polymorphisms with genetic susceptibility to tobacco related Oral Carcinoma in Asian Indians. Oral Oncol. 44: 445-63. (if=3.123)

5. Kapoor V, Singh AK, Dey S, Sharma SC, Das SN (2010). Circulating COX-2 in patients with tobacco-related intraoral Squamous cell Carcinoma and evaluation of its peptide inhibitors as potential antitumor agent. J. Cancer Res Clin Oncol 136: 1795-1804. (if=3.009)

6. Gaur P, Qadir GA, Upadhyay S, Singh AK, Shukla NK, Das SN (2012): Skewed immunological balance between Th17 (CD4+IL17A+) and Treg (CD4+ CD25+ FOXP3+) cells in human oral squamous cell carcinoma. Cellular Oncol (Dordr). 35(5):335-43. (if=3.105)

7. Jha R, Gaur P, Sharma SC and Das SN (2013) Single nucleotide polymorphism in hMLH1 promoter and risk of tobacco-related oral carcinoma in high-risk Asian Indians. Gene :526:223-227. (if=2.341)

8. Garg R, Kapoor, V, Mittal M, Singh MK, Shukla NK and Das SN (2013). Abnormal expression of PI3K isoforms in patients with tobacco-related oral squamous cell carcinoma. Clin Chim Acta. 416 (1): 100-106. (if=2.661)

9. Singh AK, Shukla NK, Das SN (2013). Altered Invariant Natural Killer T cell subsets and functions in patients with oral squamous cell carcinoma. Hum Immunol. 78: 468-477 (if=2.199)

10. Singh AK, Gaur P, Shukla NK, Das SN (2015). Differential dendritic cell-mediated activation and functions of invariant NKT cell subsets in oral cancer. Oral Dis. 21(1): e105-e113. (if=2.377)

432

HALDER, ASHUTOSH (b 1961), Professor and Head, Reproductive Biology, AIIMS, New Delhi


Dr. Halder is well known authority in Reproductive Sciences with subspecialization in Reproductive Genetics/Endocrinology/Biology. He has made significant contribution in infertility, reproductive wastage, malformations, disorder of sex development, prenatal/ preimplantation diagnosis, etc. He has developed Molecular Cytogenetic Specialty in India. He conducts national workshop annually to generate human resources in Molecular Cytogenetics besides symposium & conferences in Reproductive disorders. Dr. Halder is involved in teaching, training, research and patient care related work. He has published about 77 full length research papers, 2 full length research papers submitted (in Molecular Cytogenetics & Ind J Exp Biology; under revision), edited three books/ monograph/ laboratory manual and several book chapters (including 2 since last submission). Many of his publications are well cited; total citations are 802 (citations as of 28/02/2018 in google scholar was 742 & research gate 675). He has also undertaken several significant research projects of national agencies. His research works are on PCOS, POF, familial primary amenorrhoea, hyperprolactinemia, primary testicular failure, biological basis of skewed sex ratio and malformation. He is expert member of various National Institutes/Government Organizations, reviewer and editorial board member for various national & international medical journals. He is guiding/ guided 7 PhD student as chief guide and over 25 as co-guide/doctoral committee member besides guiding 6 DM student in past. He is the recipient of ICMR international fellowship, commonwealth scholar, pathology honor, silver medal in 3 national conferences and FAMS. He is now heading Reproductive Biology and working for several new courses.

Proposer: Prof. V.K. Paul, Seconder: Prof. R. Goswami


1. Adinolfi M, Sherlock J, Tutschek B, Halder A, Delhanty J, Rodeck C. 1995 Detection of Fetal Cells in Transcervical Sample & Prenatal Diagnosis of Chromosomal abnormalities. Prenatal Diagnosis. 15(10): 943-950. (if=2.523, ci=62)

2. Tutschek B, Sherlock J, Halder A, Delhanty J, Rodeck C, Adinolfi M. 1995 Isolation of Fetal Cells from transcervical samples by Micromanipulation: Molecular confirmation of their fetal origin and diagnosis of fetal aneuploidies. Prenatal Diagnosis. 1 (if=2.523, ci=62)

3. Halder A, Fauzdar A, Kumar A. 2005 Serum Inhibin B and Follicle Stimulating Hormone Levels as Markers in the Evaluation of Azoospermic Men: A Comparison. Andrologia 37: 173-179. (if=1.458, ci=45)

4. Sherlock J, Halder A, Tutschek B, Rodeck C, Adinolfi M. 1997 Prenatal detection of fetal aneuploidies using transcervical cell samples. J Med Genetics 34: 302-305. (if=5.451, ci=44)

5. Haldar A, Sharma AK, Phadke SR, Jain A, Agarwal SS. 1994 OEIS Complex with Cranio-Facial anomalies: Defect of Blastogenesis? Am J Med Genetics 53: 21-23. (if=2.259, ci=41)

6. Kishore R, Agarwal S, Haldar A, et al. 1996 HLA sharing, Antipaternal Cytotoxic Antibodies & MLR Blocking Factors in women with Recurrent Abortions. J Obstet Gynaecol Research 22(2): 177-183. (if=1.1, ci=40)

7. Yadav N, Sumod K, Kumar S, Jain M, Halder A, Saxena R, Mukhopadhyay A. 2009 Therapeutic effect of bone marrow-derived liver cells in phenotypic correction of murine hemophilia A. Blood 114: 4552-4561. (if=13.164, ci=34)

8. Halder A, Jain M, Kabra M and Gupta N. Mosaic 22q11.2 microdeletion syndrome: diagnosis and clinical manifestations of two cases. Molecular Cytogenetics 2008, 1:18. (if=1.558, ci=32)

9. Jauniaux E, Halder A, Partington C. A case of partial mole associated with trisomy 13. Ultrasound Obstet Gynaecol. 1998; 11(1): 62-64. (if=4.71, ci=28)

10. Agarwal S, Kishore R, Haldar A. 1995 Outcome of pregnancy in women with Recurrent Spontaneous Abortion following Immunotherapy with Allogenic Lymphocytes. Human Reproduction. 10(9): 2280-2284. (if=5.02, ci=21)

433

HANUMANTHAPPA, KRISHNA PRASAD (b 1950), Professor, Department of Biotechnology, All India Institute of Medical Sciences, New Delhi


Professor H. Krishna Prasad has been working in the field of immunology and diagnosis of Tuberculosis for more than three decades. The highlights of his research are : (i) Characterization of an antigenic DNA-binding histone-like protein (HupB) in mycobacteria, identified using a novel immuno-subtraction technique, to screen mycobacterial antigens associated with human immune response. (ii)The hupB gene was exploited to develop a rapid diagnostic PCR assay to distinguish between human and bovine tubercle bacilli. This work demonstrated that humans and cattle harbor both Mycobacterium tuberculosis and M. bovis (Zoonosis). These findings have made a significant impact on strategies to be used for the control and prevention of tuberculosis. As currently the DBT (GOI) has launched investigations on a national scale, based on these findings. (iii)Aptamers that interfere with HupB mediated functions have been developed, which are promising drug candidates. HupB constitutes a novel drug target for development of therapeutic agents for tuberculosis. In the field of immunology of tuberculosis, he analyzed human immune response among patients and contacts. He demonstrated that gamma-interferon did not offer any protection, going against existing dogma. The failure of gamma interferon to impart protective immunity was because receptors for gamma-interferon were down regulated in cells harboring tubercle bacilli. He also demonstrated alterations in dendritic cell subpopulations among TB patients, towards generation of alpha-interferon, which further down regulates gamma interferon receptors.

Proposer: Prof. Sudha Bhattacharya, Seconder: Prof. Jaya S Tyagi


1. S Prabhakar, PS Annapurna, NK Jain, AB Dey, JS Tyagi&HK Prasad.1998.Identification of an immunogenic histone–like protein (HLPmt)of Mycobacterium tuberculosis. Tub. And Lung Dis., 79, 43-53.(Impact Factor- 2.468; Citation Index- 45) (if=2.468, ci=45)

2. Dichotomy of cytokine profiles in patients and high risk healthy subjects exposed to tuberculosis.S.Bhattacharya, R.Singla, A.B,Dey, and H.K.Prasad.1999.Infection and Immunity. 67(11): 5597-5603.(Impact Factor-3.256;Citation Index-56) (if=3.256, ci=56)

3. Direct Detection and Identification ofMycobacterium tuberculosis AndMycobacterium bovis In Bovine Samples by a Novel Nested PCR Assay: Correlation with Conventional Techniques.A. Mishra, A. Singhal, D.S. Chauhan, V.M. Katoch, K. Srivastava, S.S. Thakral, S.S. Bharadwaj, V. Sreenivasand H.K. Prasad.2005.Journal of Clinical Microbiology. 43(11) (if=4.054, ci=61)

4. Occurrence of Overlooked Zoonotic Tuberculosis: Detection of Mycobacterium bovis in Human Cerebrospinal Fluid.N. P. Shah, A. Singhal,A. Jain, P. Kumar,S. S. Uppal,M. V.P. Srivatsava,and H.K. Prasad.2006. Journal of Clinical Microbiology. 1352–1358(Impact Factor-4.054;Citation Index-23) (if=4.054, ci=23)

5. Modulation of Gamma Interferon Receptor 1 by Mycobacterium tuberculosis: a Potential Immune response evasive Mechanism.A.Singhal, A.Jaiswal, V.K. Arora, and H.K. Prasad.2007.Infection and Immunity. 2500–2510 Vol. 75, No. 5.(Impact Factor-3.256;Citation Index-29) (if=3.256, ci=29)

6. Visual format for detection of Mycobacterium tuberculosis and Mycobacterium bovis in clinical samples using molecular beacons. P. Kumar, K. Nath, B. Rath, M.K. Sen, P. Vishalakshi, D.S. Chauhan, V. M. Katoch, S. Singh, S. Tyagi, V. Sreenivas, H.K.Prasad.2009.J MolDiagn. 11:430–438.(Impact Factor-4.880;Citation Index-13) (if=4.880, ci=13)

7. Disparity in circulating Peripheral blood dendritic cell subsets and cytokine profile of pulmonary tuberculosis patients compared to healthy family contacts. Gupta V, Jaiswal A, Behera D, Prasad HK.2010. Hum Immunol. 71(7):682-91.(Impact Factor-1.994;Citation Index-5) (if=1.994, ci=5)

8. Assessment of the N-PCR assay in diagnosis of pleural tuberculosis: Detection of M. tuberculosis in pleural fluid and sputum collected in tandem. Kumar P, Sen MK, Chauhan DS, Katoch VM, Singh S, Prasad HK.2010.PLoSONE. 5(4):e10220.(Impact Factor-2.766;Citation Index-11). (if=2.766, ci=11)

9. Identification of Hot and Cold spots in genome of Mycobacterium tuberculosis using Shewhart Control Charts. Das S, Duggal P, Roy R, Myneedu VP, Behera D, Prasad HK, Bhattacharya A. 2012. Sci. Rep. 2, 297; DOI:10.1038/srep00297.(Impact Factor-4.122; Citation Index-3) (if=4.122, ci=3)

10. Prevalence, Distribution and Functional Significance of the - 237C to T Polymorphism in the IL-12Rβ2 Promoter in Indian Tuberculosis Patients. Verma VK, Taneja V, Jaiswal A, Sharma S, Behera D, Sreenivas V, Chauhan SS, Prasad HK.2012. PLoS One. 7(4):e34355. (Impact Factor-2.766;Citation Index-1) (if=2.766, ci=1)

434

HUSAIN, NUZHAT (b 1961), Director, Dean Dr.RMLIMS, Officer In-charge State Referral Centre for Lab Investigations, Professor and Head of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Vibhuti Khand, Gomti Nagar, Lucknow

Member of the NASI : No (YON 2015, Medical & Forensic Sciences)

It is my pleasure to recommend NASI Fellowship for Prof. Nuzhat Husain who has outstanding academic and scientific profile. With her persistent hard work and devotion she has many Scholarships, medals and laurels to her credit. She has established Pathology department at RMLIMS with high-end equipments, has been a popular educator and enlightening guide of 30 PhD and more than 70 MD students. She has an excellent scientific profile depicted by 156 publications in National and International Journals. She has international research training on Molecular Neuro-Oncology and Gene Therapy, at Massachusetts General Hospital, Harvard University, Boston , USA. Her major research area has been Neuro pathology and Neuro-Oncology which has now further broadened to oncology. She is presently working on regulatory gene mutations, stem cells expression and liquid biopsies in various cancers. As director of RMLIMS she has an experience of government entrepreneurships, her major focus is providing high end medical care and education at an affordable cost, with the public health care system. She has innovatively established State Referral Centre for Lab Investigations, Telepathology and Telemedicine facilities at RMLIMS. Under Professor N. Husain’s leadership major expansion programs at the institute including MCI recognition and post graduate programs have been implemented. In view of her comprehensive leadership in science, academia and administration I strongly recommend her fellowship at NASI.

Proposer : Prof. Chitra Sarkar , Seconder : Prof R.K. Gupta

Ten Best Publications :

1. Husain N, Kumar P. Pathology of CNS infections. Neuro-Imaging Clinics of North America, 2011, 21 : 757-75 (if=1.47, ci=2)

2. Husain N,Kumari M, Husain M. Tumor irrigation fluid enhances diagnostic efficacy in endoscopic biopsies of intracranial space-occupying lesions. ActaNeurochir (Wien). 2010, 152 : 111-117 (if=1.788, ci=2)

3. Husain N, Seema Awasthi, Mohd Haris, Rakesh K. Gupta, Mazhar Husain. Vascular endothelial growth factor as a marker of disease activity in neurotuberculosis. Journal of Infection 2008,56 : 114-119 (if=3.72, ci=11)

4. Saksena S, Husain N, Das V, Pradhan M, Trivedi R, Srivastava S, Malik GK, Rathore RK, Sarma M, Pandey CM, Gupta RK. Diffusion tensor imaging in the developing human cerebellum with histologic correlation. Int J DevNeurosci. 2008 ,26 : 705-711. (if=2.65, ci=11)

5. Shukla N, Husain N, Jyotsna, Gupta S, Husain M. Comparisons between scolex and membrane antigens derived from Cysticercusfasciolaris and Cysticercus cellulose larvae in immunodiagnosis of human neurocysticercosis. J.MicrobiolImmunol Infect. 2008, 41 : 519-524. (if=1.75, ci=4)

6. Saksena S, Husain N, Malik GK, Trivedi R, Sarma M, Rathore RS, Pandey CM, Gupta RK. Comparative evaluation of the cerebral and cerebellar white matter development in pediatric age group using quantitative diffusion tensor imaging. Cerebellum. 2008, 7 : 392-400(if=2.89, ci=30)

7. Haris M, Husain N, Singh A, Awasthi R, Singh Rathore RK, Husain M, Gupta RK. Dynamic contrast-enhanced (DCE) derived transfer coefficient (ktrans) is a surrogate marker of matrix metalloproteinase 9 (MMP-9) expressions in brain tuberculomas. J Magn Reson Imaging 2008, 28 : 588-97 (if=2.79, ci=17)

8. Husain N. Carrier analysis for hemophilia A : ideal versus acceptable. Expert Rev. Mol Diagn 2009, 3 : 203-207 (if=4.27, ci=4)

9. Praveen Kumar, Nuzhat Husain, Priyanka Soni, Nuzhat Jahan Faridi, Sudhir Kumar Goel. New Protocol for Detection of Intron 22 Inversion Mutation from Cases With Hemophilia Clin Appl Thromb Hemost. Sep 19, 2013 (if=1.57, ci=1)

10. Raza ST, Husain N, Kumar A. Screening for hemophilia A carriers : utility of PCR-RFLP--based polymorphism analysis. Clin Appl Thromb Hemost 2009, 15 : 78-83 (if=1.57, ci=1)

435

KAKKAR, POONAM (b 1959), Chief Scientist & Area Coordinator (Regulatory Toxicology); Professor (AcSIR); Dy. TFM (In-charge) Toxicity Testing: GLP Test Facility; CSIR-Indian Institute of Toxicology Research, Lucknow


Prof. Kakkar’s pioneering research showed mitochondrial damage by ROS/ oxidative stress as key phenomena in toxicity of drugs/chemicals and diabetes (Free Radic. Biol. Med, 1991). The highly sensitive method developed by her for estimation of superoxide dismutase (Ind. J. Biochem. Biophys., 1984); is the highest cited paper (2900 citations) of CSIR. She demonstrated for the first time hepato-protection by probiotics in acetaminophen induced apoptosis (Food Chem Toxicol,2011). Her novel approaches provided evidence for intervention by phytochemicals/ herbal extracts in redox mediated cellular signalling. She showed natural terpenes protected against redox imbalance and calcium dependent mitochondrial dysfunction in nimesulide-hepatotoxicity (PLoS One,2012). Regulation of carbohydrate metabolism by Berberis aristata extract in diabetic rats (J. Ethnophramacol, 2009) observed in vivo led to formulation of nanotized berberine which gave protection at low doses. More recently she reported berberine induced FoxO proteins’ nuclear retention, Bim/PUMA induction, mitochondrial dysfunction and apoptosis in HepG2 cells (FRBM,2014;TAAP,2016). She also reported essential role of PHLPP2 in suppression of redox sensitive transcription factor Nrf2 via modulation of Akt/GSK3β/Fyn kinase axis during oxidative hepatotoxicity (Cell Death & Disease,2014) and its modulation by Morin (Redox Biol., 2015). She was a key member for development of pharmacopoeial standards of Ayurvedic drugs (API, 2006). Her observation of decline in antioxidant capacity of herbal teas during storage (Food Res. Int,2006) reiterated need for expiry date on herbal products. Her findings on safety of herbo-mineral Ayurvedic drugs and heavy metals in medicinal plants were cited by Government of India to rebut a US report.

Proposer: Prof. P. K. Seth, Seconder: Prof. C. S.Nautiyal


1. Kakkar P, Das B and Viswanathan PN (1984). A modified spectrophotometric assay of superoxide dismutase. Ind. J. Biochem. Biophys., 21: 130 132. (if=0.958, ci=2900)

2. Mehrotra S, Kakkar P and Viswanathan PN (1991). Mitochondrial damage by active oxygen species in vitro. Free Radical Biol. Med., 10: 277 285. (if=5.982, ci=57)

3. Naithani V, Nair S and Kakkar P (2006). Decline in antioxidant capacity of Indian herbal teas during storage and its relation to phenolic content. Food Res Int., 39: 176-181. (if=3.871, ci=69)

4. Singh J and Kakkar P (2009). Antihyperglycemic and antioxidant effect of Berberis aristata root extract and its role in regulating carbohydrate metabolism in diabetic rats. Journal of Ethnopharmacology, 123:22-26. (if=3.333, ci=125)

5. Singh BK, Tripathi M, Chaudhari BP, Pandey PK and Kakkar P (2012). Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats. PLoS One,7(4):e34200. (if=3.540, ci=58)

6. Sharma S, Singh RL and Kakkar P (2011). Modulation of Bax/Bcl-2 and caspases by probiotics during acetaminophen induced apoptosis in primary hepatocytes. Food Chem. Toxicol., 49: 770-779 (if=3.440, ci=32)

7. Rizvi F, Shukla S and Kakkar P (2014). Essential role of PH domain and leucine-rich repeat protein phosphatase 2 in Nrf2 suppression via modulation of Akt/GSK3β/Fyn kinase axis during oxidative hepatocellular toxicity. Cell Death & Disease, 5(3), e1 (if=5.378, ci=17)

8. Shukla S, Rizvi F, Raisuddin S and Kakkar P (2014). FoxO proteins’ nuclear retention and BH3-onlyprotein Bim induction evoke mitochondrial dysfunction-mediated apoptosis in berberine-treated HepG2 cells. Free Radical Biology & Medicine, 76:185-199 (if=5.982, ci=15)

9. Rizvi F, Mathur A, Krishna S, Siddiqi MI, Kakkar P (2015). Suppression in PHLPP2 induction by morin promotes Nrf2-regulated cellular defenses against oxidative injury to primary rat hepatocytes. Redox Biol., 6:587-598. (if=6.235, ci=3)

10. Shukla S, Sharma A, Pandey VK, Raisuddin S, Kakkar P (2016). Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 (if=4.010, ci=3)

436

KAR, SHANTANU KUMAR (b 1952), Director (Research) Medical & Life Sciences, IMS & SUM Hospital, SOA University, Bhubaneswar


Dr. SK Kar, MD (Medicine), having brilliant academic record with 38 years of research carrier in ICMR, acclaimed several national and other awards for his research contributions in areas of tropical diseases, clinical, therapeutics and vaccine tools towards control and elimination of diseases of poverty like Filariasis and cholera. He is first to demonstrate the usefulness of Ivermectin as an scabicidal agent besides acting as antifilarial drug being used now and tissue tonometry to accurately measure lymhoedema status in filarial lymphoedema. He has conducted for the first time globally, the phase IV vaccine trial in public health setting with oral cholera vaccine (Sanchrol) in prevention of cholera. His clinical drug trials on antifilarials has shown effective drug regimens for control and elimination of Filariasis. His research influenced national and global policies in elimination of Filariasis and cholera. He was a recipient of ICMR National Talent Search Fellowship, and awarded as a Fellow of National Academy of Medical Sciences and Fellow of Indian College of Physicians. He received MOT Iyenger National ICMR award, Rajiv Gandhi Sadbhawana award for excellence in medical science and Kalinga Gastro Enterology Foundation Samman for contribution towards HBV prevention. He has over 170 research publications in reputed International and National Journals beside eleven chapters in books and monographs during his research career including 20 years as Directorship in two ICMR institutes, RMRC Bhubaneswar and RMRI Patna.

Proposer: Dr. Sujit Kumar Bhattachary, Seconder: Dr. T. Ramamurthy


1. Kar S.K.,Mania J.(1993). Tropical pulmonary eosinophilia in an orissa village. National Medical Jouranl of India. 6(2). 64-67 (if=1.412, ci=3)

2. Kar S.K., (1993).The sheath of the microfilaria of Wuchereria bancrofti has albuin and immunoglobulin on its surface. Parasite Immunolgy. 15(5). 297-300 (if=2.493, ci=9)

3. Kar S.K., (1993). Side reactions following ivermectin therapy in high density bancroftian microfilaraemics. Acta Tropica. 55(1-2)53-60 (if=2.414, ci=9)

4. Kar S.K.,Mania J.,Kar P.K.,(1993). Prevealence of lymphatic nodule in a bancroftian endemic population. Acta Tropica.55(1-2). 53-60 (if=2.414, ci=5)

5. Kar S.K.,Mania J.,Kar P.K.,(1993). Humoral immune response during filaria fever in Bancroftian filariasis. Transactions of the Royal Society of Tropical Medicine and Hydiene. 87(2).230-233 (if=1.931, ci=17)

6. Babu BV, Kar SK. (2004). Domestic violence against women in eastern India: A population based study on prevalence and related issues. BMC Public Health. 124(3). 136-148 (if=2.825, ci=71)

7. Kar S.K,Pach A,Sah B,(..),Wierzba T.F.,Kaljee L.M.,(2014). Uptake during an oral cholera vaccine pilot demonstration programme.odisha,India. Hum. Vac. & Immu. 10(10). 2834-2842 (if=3.643, ci=2)

8. Kar S.K.,Sah B,Patnaik B,(..),Clemen J.D.,Wierzba T.F.,(2014). Mass vaccination with new,less expensive oral cholera vaccine using public health infrastructure in India:The Odisha model open access. Plo. Neg. Tro. Dis. 8(2).e2629. (if=3.834, ci=21)

9. Kar SK,Dwibedi B,Karketa A.S,(...),Horton J,Ramachandran C.P, A Kar SK,Dwibedi B,Karketa A.S,(...),Horton J,Ramachandran C.P, (2015). A randomized controlled trial of increased dose and frequency of Albendazole with standard dose DEC for treatment of (if=3.834, ci=2)

10. Kar S.K.,Kar S.K., Lymphatic pathology in asymptomatic and symptomatic children with Wuchereria bancrofti infectin in children from Odisha, India and its reversal with DEC and albendazole treatment. Plos Neglected Tropical Diseases. 11(10). e0005631 (if=3.834, ci=0)

437

MISRA, RAMNATH (b 1954), Sanjay Gandhi Post Graduate institute of Medical Sciences, Lucknow


He has contributed to advance the knowledge of pathogenesis of Reactive arthritis and Systemic lupus erythematosus and Takayasu arteritis . Reactive arthritis is triggered by gut or genitourinary infection and affecting young individuals. His studies have identified that the salmonella outer membrane proteins A are the major antigenic target of synovial fluid T cells and OmpA stimulates synovial fibroblasts to produce pro inflammatory cytokines IL-17 and IL-6. He was the first to describe increase in IL-17 in synovial fluid of these patients which have a potential therapeutic potential as antibodies to IL-17 is now approved in patients with spondyloarthropathy. In Takayasu arteritis (TA) his outstanding contribution is the standardization of an clinical disease activity tool (ITAS 2010) which has gained international usage. In SLE his studies showed the genes associated with Indian patients , seizures, increased T cell apoptosis with lymphopenia and increased excretion of urinary Complement split product C3d as a biomarker of active lupus nephritis. In Rheumatoid arthritis , he showed that young Indian patients have evidence of subclinical artherosclerosis. His group for the first time reported cohort of patients with Primary Sjogrens Syndrome, Mixed Connective tissue disease, and long term outcome of patients with lupus nephritis from our country. Further, he described that Juvenile idiopathic arthritis is different than what is seen in Western countries.

Proposer: Prof. Rakesh Kapoor, Seconder: Prof. U.K. Misra


1. Misra R,Danda D, Rajappa SM, Ghosh A, Gupta R, Mahendranath KM, et al. 2013. Development and initial validation of the Indian Takayasu Clinical Activity Score (ITAS2010). Rheumatology (Oxford). 2013;52:1795-801. (if=4.4, ci=27)

2. Dhir V, Singh AP, Aggarwal A, Naik S, Misra R. Increased T-lymphocyte apoptosis in lupus correlates with disease activity and may be responsible for reduced T-cell frequency: a cross-sectional and longitudinal study. Lupus. 2009;18:785-91. (if=2.8, ci=20)

3. Singh R, Aggarwal A, Misra R.2007. Th1/Th17 cytokine profiles in patients with reactive arthritis/undifferentiated spondyloarthropathy. J Rheumatol. 2007;34:2285-90. (if=3.17, ci=122)

4. Singh R, Shasany AK, Aggarwal A, Sinha S, Sisodia BS, Khanuja SP, et al. 2007. Low molecular weight proteins of outer membrane of Salmonella typhimurium are immunogenic in Salmonella induced reactive arthritis revealed by proteomics. ClinExpImmunol. 2007;148:486-93. (if=3.28, ci=25)

5. Grover S, Sinha RP, Singh U, Tewari S, Aggarwal A, Misra R.2006 . Subclinical atherosclerosis in rheumatoid arthritis in India. J Rheumatol. 2006;33:244-7. (if=3.17, ci=64)

6. Shrivastava A, Dwivedi S, Aggarwal A, Misra R. Anti-cardiolipin and anti-beta2 glycoprotein I antibodies in Indian patients with systemic lupus erythematosus: association with the presence of seizures. Lupus. 2001;10:45-50. (if=2,48, ci=46)

7. Misra R, Darten K, Jewkes RPF, Black CM, Maini RN. Arthritis in scleroderma. Brit J Rheumatol (Rheumatology) 1995;34:831-7.(if=4.44, ci=64)

8. Aggarwal A, Misra R. Juvenile chronic arthritis in India: is it different from that seen in Western countries? Rheumatol Int. 1994;14:53-6. (if=1.63, ci=58)

9. Wakhlu A, Krisnani N, Hissaria P, Aggarwal A, Misra R. Prevalence of secondary amyloidosis in Asian North Indian patients with rheumatoid arthritis. J Rheumatol. 2003;30:948-51. (if=3.17, ci=42)

10. Misra R, Aggarwal A, Chag M, Sinha N, Shrivastava S. Raised Anti-cardiolipin antibodies in Takayasu’s arteritis. Lancet 1994; 343: 1644-5. (if=39.21, ci=25)

438

PATURU, KONDAIAH (b 1954), Professor, Dept. of MRDG, Indian Institute of Science, Bangalore


Prof. Kondaiah is an established and highly accomplished Cancer Biologist. He made seminal contributions towards the understanding of signaling pathways involved with fibrosis, breast cancer and glioma. His laboratory extensively used microarrays as a tool to understand the pathways involved in TGF-beta signaling, breast cancer prognosis, etio-pathogenesis of oral submucous fibrosis and role of IGFBPs in progression of breast cancer and glioma. His group demonstrated differential regulation of genes by TGF-beta in normal and tumor cells demonstrated the differential activation of non canonical and MAPK signaling in tumor and non tumor cells by TGF-beta. This work resulted in the identification of S100A2 as an intermediate in TGF-beta actions. Using a variety of in vitro and in vivo experiments the role of S100A2 has been demonstrated in the progression of cancers. Activation of TGF-beta1 by laser and a mechanism for faster healing of soft tissues was also an interesting demonstration by his group. With respect to glioma, a role for IGFBP 2,3 and 4 isoforms in glioma progression has been proposed and demonstrated the importance of IGFBP2 actions in the regulation of bet-catenin. This work identified IGFBP2 as an important therapeutic target for glioblastoma. Importantly, his group elucidated the mechanism of areca nut induction of TGF-beta pathway that has enormous implications in the etiology of Oral Submucous Fibrosis. Significantly, his group along with chemists identified a small molecule which acts on mutant form of p53 resulting in wild type conformation and activates the p53 dependent apoptosis.

Proposer: A. Jagannadha Rao, Seconder: Rajan R. Dighe


1. Ranganathan P, Agrawal A, Bhushan R, Chavalmane CK, Kalathur RK, Takahashi T, Kondaiah P*. Expression profiling of genes regulated by TGF-beta: Differential Regulation in Normal and Tumor cells BMC Genomics Apr 11; 8(1):98 2007. (if=4,1, ci=55)

2. Arany PR, Nayak RS, Hallikerimath S, Limaye AM, Kale AD, Kondaiah P* 2007. Activation of Latent TGF-β1 by low power laser in vitro correlates with increased TGF-β1 levels in laser enhanced oral wound healing Wound Repair Regen. 15(6):866-74 (if=2.768, ci=46)

3. Reddy PS, Britto R, Vinnakota K, Aparna H, Sreepathi HK, Thota B, Kumari A, Shilpa BM, Vrinda M, Umesh S, Samuel S, Shetty M, Tandon A, Pandey P, Hegde S, Hegde AS, Balasubramaniam A, Chandramouli BA, Santhosh V, Kondaiah P*, Somasundaram K*, Rao (if=8.738, ci=70)

4. Santosh V, Arivazhagan A, Sreekanthreddy P, et al. 2010. Grade specific expression of IGFBP-2, -3 and -5 in astrocytomas--- Cancer Epidemiol. Biomarkers & Prev. 2010 19(6):1399-1409 (if=3.622, ci=39)

5. Khan I, Agarwal P, Thangjam GS, Radhesh R, Rao SG and Kondaiah P*.2011..Role of TGF-β and BMP7 in the pathogenesis of oral submucous fibrosis. Growth Factors, 29(4):119-27 (if=2.92, ci=22)

6. 6. Naz S, Ranganathan P, Bodapati P, Shastry AH, Mishra LN, Kondaiah P*. Regulation of S100A2 Expression by Transforming Growth Factor-β induced MEK/ERK Signaling and its role in Cell Migration/Invasion. Biochem J. 447(1):81-91 2012 (if=4.654, ci=19)

7. 7. Naz S, Bashir M, Ranganathan P, Bodapati P, Santosh V and Kondaiah P*. Pro tumorigenic actions of S100A2 involves regulation of PI3/Akt signaling and functional interaction with Smad3. Carcinogenesis. 35(1):14-23. 2013 (if=5.334, ci=10)

8. Sehgal P, Kumar N, Praveen Kumar VR, et al 2013 Regulation of protumorigenic pathways by Insulin like growth factor binding protein2 and its association along with β-catenin in breast cancer lymph node metastasis. Mol Cancer. 12(1):63, 2013 (if=5.88, ci=14)

9. Patil SS, Priyanka G, Bashir M, S et al 2016 (Nov). Insulin like Growth Factor Binding Protein-2 regulates β-catenin signaling pathway in glioma cells and together contribute poor patient prognosis. Neuro-Oncol, 18(11):1487-1497 (if=7.371, ci=0)

10. Pant I, Rao SG and Kondaiah P*: 2016. Role of areca nut induced JNK/ATF2/Jun axis in the activation of TGF-β pathway in precancerous Oral Submucous Fibrosis. Sci Rep. 2016 Oct 6;6:34314. (if=5.22, ci=0)

439

REDDY SHETTY, PRAKASHAM (b. 1960) Senior Principal Scientist, IICT, Hyderabad

Member of the NASI : No (YON 2015, Medical & Forensic Sciences)

-Developed hydrogels and evaluated the bioefficacy of alpha glucans, serralysin as anti-inflammatory, fibrinolytic, anti-microbial and wound-healing agents -Unraveled the involvement of two ammonium transport systems and their regulatory role in inhibition/stimulation of ammonium/glutamate transport -Decoupling of biomass growth and its bioproduct production by modulating cellular metabolism to develop a recycle and reusable biocatalyst and to improve bioethanol process. -Functionalization of biopolymer, ferric/nickel impregnated silica nanoparticles and understanding its robustness as well as evaluation of its role as immobilizing matrix in enantioselective lactic acid production - used in biopolymer production -Evaluating the Taguch methodology as a statistical tool for biotechnological applications for first time. -Unraveling the role of barbital in modulation of metabolism linked to improved production (120%) of rifamycin in Nocardia strain and understanding the alkaline. protease production kinetics and developing the a mathematical model -Developed rapid bioprocesses for silver nanoparticles, xylooligosaccharides, fructooligosaccharides, polygalacturonasem, prodigiosin wine, L-asparaginase, L-glutaminasee, proteases, serralysin, L-lactic acid, rifamycin, actinomycin, epothelon, tyrosinase, xylanase, xylitol and defloridation using untapped agroindustrial materials. -Understanding of, glucose to xylose ratio, high biomass and sweet sorghum juice for effective biohydrogen as well as bioethanol production from lignocellulosic biomass. -Heterologous expression of CYP I 02A5 variant and its production as well as predicting drug metabolism of human P450 probe substrates and in silico molecular docking of prodigiosin and cycloprodigiosin as COX-2 inhibitors -Evaluating the functionalized polyamide membrane for treating the bulk drug industrial effluent. -Demonstrated the technologies (xylitol from biomass, xanthan gum, ethanol, and xylose) to industries.

Proposer: Prof. Appa Rao Podile, Seconder: Prof. P.B. Kavi Kishor Ten Best Publications: 1. R S Prakasham, J Sheno Merrie, R Sheela, N Saswathi and S V Ramakrishna. 1999. Biosorption of chromium VI by free and immobilized Rhizopus arrhizus. Environ. Pollution (UK), 104/3,421- 427. (If-3.902: ci = 204) 2. R S Prakasham, Ch Subba Rao and P N Sarma. 2006. Green gram husk as innovative and inexpensive support for alkaline protease production by isolated Bacillus sp. under solid-state fermentation. Bioresource Technology, 97, 1449-1454. (IF-5.039: CI = 164) 3. R S Prakasham, Sarala Devi, K Rajya Laxmi and Ch Subba Rao. 2007. Novel Synthesis of Ferric Impregnated silica nanoparticies and their evaluation as matrix for enzyme immobilization. J Phys. Chern. C. 111, 3842-3847. (If-4.835, ci=38) 4. P Brahmaiah, Ch Subba Rao, T Satish and R S Prakasham. 2013. Heterologous expression of CYP102A5 variant from Bacillus cereus CYPPB- J: Validation of model for predicting drug metabolism of human P450 probe substrates. Appl Microbiol Biotechnol. 97, 8107-8719 (if 3.811) 5. B. VenkataSwamy, M. Madhumala, R.S. Prakash am, S. Sridhar. 2013. Nanofiltrationof Bulk Drug Industrial Effluent using Indigenously Developed Functionalized Polyamide Membrane. Chemical Engineering 1. 233,193-200. (if-3.473: ci = 2) 6. P Laxmi Bharghavi and R S Prakasham. 2013. A fibrinolytic, alkaline and thermostable metalloprotease from the newly isolated Serratia sp RSPB II. International Journal of Biological Macromolecules. 61,479-486. (if - 3.227: ci = 3) 7. B Sudheer Kumar, V V N Yaswanth, R S Prakasham. 2015. Fibrinolytic, anti-inflammatory and anti-microbial properties of a-(l-3)-glucans produced from Streptococcus mutans (MTCC497). Carbohydrate Polymers, 115, 152-159. (If-3.916). 8. AA Murthy, ML Kantam, B Jagadeesh, SV Phani Babu, Bhargava, B Sudheer Kumar, RS Prakasham. Ce/Si02 composite as an efficient catalyst for the muiticomponent one-pot synthesis of substituted pyrazolones in aqueous media and their antimicrobial activities. Journal of Molecular Catalysis A: Chemical 411 (2016) 325-336 (if-3.615) 9. P Ramesh, K Srinivasa Rao, R Trivedi, B Sudheer Kumar, R S Prakasham, B Sridhar. Highly efficient regio and diasteroselective synthesis of functionalized bis-spirooxindoles and their antibacterial properties. RSC Advances, 2016 in press, DOl: 10.1039/C6RA00613B. (If-3.84) 10. C Sushma, V Venkata Dasu, J Ahmad, R S Prakasham. High yield expression of novel glutaminase free L-asparaginase II of Pectobacterium carotovorum MTCC1428 in Bacillus subtilis WB800N. Bioprocess Biosys Engg. 38, 2015, 2271-2284. (If - 1.997)

440

SHARMA, AMAN (b 1974), Professor, Clinical Immunology and Rheumatology wing, Internal Medicine, PGIMER, Chandigarh


It gives us immense pleasure to nominate Prof Aman Sharma who has done exciting clinical, imaging, cytokines and proteomics studies in vasculitis. His group validated EMA classification system and proposed that the ACR criteria for PAN should be included in this algorithm. His group also published long term outcomes in a large cohort of 105 GPA patients, studied the association of histopathological classification and renal manifestations with outcomes and showed that the patients with sclerotic disease had the worst outcomes. His group also reported that patients of pauciimune glomerulonephritis with ANCA negativity had more renal involvement, with dialysis dependence and less joint and neurological involvement. His group has also published the cytokine profile and proteomics work done on MALDI-TOF in patients with GPA. His group reported two novel mutations in Deficiency of ADA2 (DADA2) PAN. In recognition of his work, he was invited to be an expert reviewer for the ACR EULAR study group which developed the classification criteria of GPA, MPA, EGPA and Takayasu’s arteritis. He was written a very popular textbook of systemic vasculitis and was guest Editor of special issues on vasculitis in International Journal of rheumatic diseases and Indian Journal of rheumatology. He has started the Indian Vasculitis Registry and Indian Relapsing polychondritis registry. He has 287 peer reviewed publications, written 45 book chapters and has edited three books. He has been awarded IRA oration, Zydus oration, R Subramanian oration, and Rabindranath oration. He was done collaborative resaerch in uveitis and tuberculosis.

Proposer: Prof. Arunaloke Chakrabarti, Seconder: Dr. Javed Agrewala


1. Gupta V, Gupta A, Gupta P, Sharma A.2009. Spectral-Domain Cirrus Optical Coherence Tomography of Choroidal Striations Seen in the Acute Stage of Vogt-Koyanagi-Harada Disease. Am J Ophthalmol. 147:148-153.e2. (if=4.795 , ci=64)

2. Sharma A, Kumar S,Wanchu A,Sharma K, Sharma N, Singh R, Bambery P, Singh S, Varma S. 2010. Clinical characteristics and predictors of mortality in 67 patients with Primary pyomyositis: A study from North India. Clinical Rheumatol.29:45-51. (if=2.141 , ci=38)

3. Sharma A, Kumar S, Wanchu A, Lal V, Singh R, Gupta V, Singh S, Gupta A.2010. Successful treatment of hypertrophic pachymeningitis in refractory Wegener's granulomatosis with rituximab. Clin Rheumatol.29:107-10. (if=2.141 , ci=51)

4. Gupta A, Bansal R, Gupta V, Sharma A, Bambery P.2010 Ocular Signs Predictive of Tubercular Uveitis. Am J Ophthalmol. 149:562-70.(if=4.795 , ci=164)

5. Sharma K, Sharma A, Ray P, Sharma SK, Modi M, Prabhakar S, Varma S, Sharma M. 2011. Multiplex PCR for rapid diagnosis of tuberculous meningitis. J Neurol. 258:1781-7. (if=3.783 , ci=73)

6. Bansal R, Gupta A, Gupta V, Dogra MR, Sharma A, Bambery P.2012. Tubercular serpiginous-like choroiditis presenting as multifocal serpiginoid choroiditis. Ophthalmology 119:2334-42 (if=7.479 , ci=99)

7. Arnaud L, Devilliers H, Peng SL, Mathian A, Costedoat- Chalumeau N,Buckner J, Dagna L, Michet C, Sharma A et al 2012.The Relapsing Polychondritis Disease Activity Index: development of a disease activity score for relapsing polychondritis. Autoimmun(if=8.749 , ci=47)

8. Sharma A, Gnanapandithan K, Sharma S,Sharma K. 2013. Relapsing Polychondritis- A review. Clin Rheumatol.32:1575-83. (if=2.141 , ci=67)

9. Sharma A, Arjun D Law, Bambery P, Sagar V, Wanchu A, Dhir V, Vijayvergiya R, Sharma K, Gupta A, Panda N, Singh S.2014. Relapsing Polychondritis: Clinical presentations, disease activity and outcomes: Orphanet J Rare Dis.9:198. (if=3.607 , ci=31)

10. Rathi M, Goyal A, Jaryal A, Sharma A, Gupta PK, Ramachandran R, Kumar V, Kohli HS, Sakhuja V, Jha V, Gupta KL.2016. Comparison of low-dose intravenous cyclophosphamide with oral mycophenolate mofetil in the treatment of lupus nephritis. Kidney Int.89(if=8.429 , ci=47)

441

SINGH, SUNIT KUMAR (b 1971), Professor, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005


Dr. Sunit K. Singh has completed his Ph.D. in the area of Infection Biology from the University of Wuerzburg, Wuerzburg, Germany and postdoctoral training from Yale University School of Medicine, New Haven, USA and the University of California, Davis, USA. Dr. Singh served as a faculty member (Scientist) at CCMB, Hyderabad. Currently, Dr. Singh is working as Professor (Molecular Immunology) at the Molecular Biology Unit, Institute of Medical Sciences, BHU, Varanasi. My interest in Dr. Singh reflects his ability to work across different types of viruses, including retroviruses (HIV-1), alphaviruses, and flaviviruses. Dr. Singh has published excellent papers in internationally reputed peer-reviewed journals in the area of molecular virology. Dr. Singh has published excellent research papers in the peer-reviewed international journals such as “Lancet Infectious Diseases”, “The Journal of Neuroscience”, BMC Neuroscience”, Annals of Rheumatic Diseases “Journal of Neuroinflammation” and many others. He has received FEBS Top Cited Paper Award” by the peer-reviewed journal “The FEBS journal”. Dr. Singh has edited four important books titled: Neuroviral infections (two volumes), book titled “Viral Hemorrhagic Fevers” and book titled “Human Respiratory Viral Infections” published by CRC/Taylor & Francis publication, USA and a fourth book titled “Viral Infections and Global Change” by Willey Blackwell, USA. Dr. Singh has excelled with fundamental leadership quality in his area of work, which is very much related to the health and well being of the population of this country. Therefore, I strongly nominate Dr. Sunit Kumar Singh for the fellowship of National Academy of Sciences of India.

Proposer: Dr. Lalji Singh, Seconder: Dr. Anirban Basu


1. S.K. Singh and H.J. Girschick, 2004, Molecular survival strategies of the Lyme disease spirochete Borrelia burgdorferi; Lancet Infectious diseases, 4(9): 575-583. (if=19.864, ci=108)

2. H. Morbach, S.K. Singh, C. Faber, A. Grammer, P. E. Lipsky, H.J. Girschick, 2006, Analysis of RAG expression by peripheral blood CD5+ and CD5- B cells of patients with childhood Systemic Lupus Erythematosus. Annals of Rheumatic Diseases,65(4): 482-7.(if=12.384, ci=30)

3. R Mishra, C Chhatbar and S.K Singh, 2012, HIV-1 Tat C-mediated regulation of tumor necrosis factor receptor-associated factor-3 by microRNA 32 in human microglia, Journal of Neuroinflammation, Jun 18;9:131. doi: 10.1186/1742-2094-9-131 (if=5.193, ci=40)

4. R Mishra, and S.K Singh, 2013, HIV-1 Tat C modulates expression of miRNA-101 to suppress VE-Cadherin in Human Brain Microvascular Endothelial Cells, The Journal of Neuroscience 33(14):5992-6000; doi:10.1523/JNEUROSCI.4796-12.2013 (if=6.51, ci=45)

5. G.D. Manocha, R. Mishra, N. Sharma, K.L. Kumawat, A. Basu, S.K. Singh, 2014, Regulatory role of TRIM21 in type-I interferon pathway in Japanese encephalitis virus infected human microglial cells Journal of Neuroinflammation, Feb 1;11:24. doi: 10.1186/1742-2094-11-24 (if=5.193, ci=32)

6. R. Mishra, S.K. Singh, 2014, HIV-1 Tat C phosphorylates VE-cadherin complex and increases human brain microvascular endothelial cell permeability, BMC Neuroscience 2014 Jun 26; 15(1):80. doi: 10.1186/1471-2202-15-80) (if=2.850, ci=25)

7. S.P Selvamani, R. Mishra, S.K. Singh, 2014, Chikungunya virus exploits miR-146a to regulate NF-ҡB pathway in human synovial fibroblasts, PLoS One. Aug 1; 9(8):e103624. doi: 10.1371/journal.pone.0103624. (if=3.10, ci=30)

8. V. Jadhav; K-H. Krause; S.K. Singh, 2014, HIV-1 Tat C modulates NOX2 and NOX4 expressions through miR-17 in Human Microglial Cells, Journal of Neurochemistry. Dec; 131(6):803-15. (if=4.609, ci=33)

9. N. Sharma, R. Verma, K.L Kumawat, A. Basu and S.K Singh, 2015, miR-146a suppresses cellular immune response during Japanese encephalitis virus JaOArS982 strain infection in human microglial cells, Journal of Neuroinflammation, Feb 18;12:30. doi: 10.1186/s12974-015-0249-0 (if=5.193, ci=60)

10. N. Sharma, K.L. Kumawat, M. Rastogi, A. Basu, S.K. Singh, 2016, Japanese Encephalitis Virus exploits the microRNA-432 to regulate the expression of Suppressor of Cytokine Signaling (SOCS) 5, Scientific Reports 2016 Jun 10;6:27685. doi: 10.1038/srep27685(if=4.259, ci=32)

442

TOTEJA, GURUDAYAL SINGH (b 1958), Director, Desert Medicine Research Centre (ICMR), Jodhpur; Scientist-‘G’ & Head (Nutrition), Indian Council of Medical Research, New Delhi and Head, Centre for Promotion of Nutrition Research and Training..(ICMR), 3 Red Cross Road, New Delhi


Dr. Toteja has 40 years of experience in the field of biomedical research. He has addressed several issues of public health importance which have either benefitted population directly or had significant impact on policy and programmes of Government. ACHIEVEMENTS: (1) Developed district level model to combat malnutrition (2) Capacity building for health care providers in North East and Tribal region of country (3) Promoted research among medical colleges of India especially those in periphery by having several methodology workshops and scientific studies in collaboration with them (4) Dr. Toteja’s recent contribution is establishment of Model Rural Health Research Unit (under Department of Health Research, Ministry of Health & Family Welfare, Government of India) at Bhanpurkala, Jaipur with an aim to create infrastructure at the periphery for transfer of technology to the rural level for improving the quality of health services (5) Maximum residue limits for pesticides fixed by FSSAI for various food commodities to monitor pesticide residues for protection of consumers, For eg., limits of pesticide residues in carbonated water (soft drinks), honey, milk etc. (6) Number of mega studies launched which will have impact on policies and programmes. These are sickle cell anaemia in Rajasthan (70000 children screened), breast cancer (25,000 women screened in Rajasthan). Dr. Toteja has been awarded Fellowship by National Academy of Medical Sciences (FAMS) for his significant contribution in the field of Medical Science.

Proposer: Dr. Ravinder Goswami, Seconder: Dr. Jaya S Tyagi


1. Patel SA, Dhillon PK, Kondal D, Jeemon P, Kahol K, Manimunda SP, Purty AJ, Deshpande A, Negi PC, Ladhani S, Toteja GS, Patel V, Prabhakaran D. Chronic disease concordance within Indian households. PLoS Med. 2017;14(9)e:e1002395 (if=11.862, ci=4)

2. Bothra N, Shah N, Goroshi M, Jadhav S, Padalkar S, Thakkar H, Toteja GS, Shivane V, Lila A, Bandgar T. Hashimoto's thyroiditis: relative recurrence risk ratio and implications for screening of first-degree relatives. . Clin Endocrinol (Oxf). 2017;87(2):201-206 (if=3.327, ci=3)

3. Bansal PG, Toteja GS, Bhatia N, Siddhu A, Vikaram NK. Impact of weekly iron folic acid supplementation with and without vitamin B12 on anaemic adolescent girls-a randomized clinical trial. European Journal of Clinical Nutrition , (23 December 2015) | doi:10.1038/ejcn.2015.215 (if=2.709, ci=7)

4. Mazumder S, Taneja S, Bhatia K, Yoshida S, Kaur J, Dube B, Toteja GS, Bahl R, Fontaine O, Martines J, Bhandari N; for the Neovita India Study Group. Efficacy of early neonatal supplementation with vitamin A to reduce mortality in infancy in Haryana, India (Neovita): a randomised, double-blind, placebo-controlled trial. Lancet. 2014 Dec 10. pii: S01 (if=45.217, ci=52)

5. Agarwal R, Virmani D, Jaipal M, Gupta S, Sankar MJ, Bhatia S, Agarwal A, Devgan V, Deorari A, Paul VK, Toteja GS; Investigators of the LBW Micronutrient Study Group. Poor zinc status in early infancy among both low and normal birth weight infants and their mothers in Delhi. Neonatology. 2013; 103(1):54-9 (if=2.649, ci=13)

6. Siruguri V, Kumar PU, Raghu P, Rao MV, Sesikeran B, Toteja GS, Gupta P, Rao S, Satyanarayana K, Katoch VM, Bharaj TS, Mangat GS, Sharma N, Sandhu JS, Bhargav VK, Rani S. Aflatoxin contamination in stored rice variety PAU 201 collected from Punjab, India.Indian J Med Res. 2012;136(1):89-97 (if=1.396, ci=20)

7. T. Longvah, G.S. Toteja, G. Bulliyya,R.S. Raghuvanshi, Shashi Jain, Vishnuvardhan Rao, A. Upadhya. Stability of added iodine in different Indian cooking processes. Food Chemistry 2012;130(4):953–959 (if=3.391, ci=18)

8. Sharma SK, Puri R, Jain A, Sharma MP, Sharma A, Bohra S, Gupta YK, Saraya A, Dwivedi S, Gupta KC, Prasad M, Pandey J, Dohroo NP, Tandon N, Sesikeran B, Dorle AK, Tandon N, Handa SS, Toteja GS, Rao S, Satyanarayana K, Katoch VM. Assessment of effects on health due to consumption of bitter bottle gourd (Lagenariasiceraria) juice. Indian J Med Res. 20 (if=1.396, ci=33)

9. Ganguly NK, Bhattacharya SK, Sesikeran B, Nair GB, Ramakrishna BS, Sachdev HP, Batish VK, Kanagasabapathy AS, Muthuswamy V, Kathuria SC, Katoch VM, Satyanarayana K, Toteja GS, Rahi M, Rao S, Bhan MK, Kapur R, Hemalatha R. ICMR-DBT guidelines for evaluation of probiotics in food. Indian J Med Res. 2011; 134:22-5 (if=1.396, ci=53)

10. Toteja GS, Singh P, Dhillon BS, Saxena BN, Ahmed FU, Singh RP, Prakash B, Vijayaraghavan K, Singh Y, Rauf A, Sarma UC, Gandhi S, Behl L, Mukherjee K, Swami SS, Meru V, Chandra P, Chandrawati, Mohan U. Prevalence of anemia among pregnant women and adolescent girls in 16 districts of India. Food Nutr Bull. 2006; 27(4):311-5 (if=1.148, ci=248)

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