THE LIFE$SCIENCES$ INSTITUTElsi-dev.sites.olt.ubc.ca/files/2014/11/LSI-All... ·...

THE LIFE SCIENCES INSTITUTE Pieter Cullis, Professor & Director

The Life Sciences Institute

Life Sciences Institute: Vision

1.  Maintain and improve excellence in basic life science research

2.  Achieve global compe@@veness in transla@onal research to the clinic by pursuing personalized medicine opportuni@es

3.  Achieve global compe@@veness in commercializa@on ac@vi@es

2


Life Sciences Institute: Overview & Facts

3


Vision for the LSI 2018: Best in Canada and Amongst Top Ten in World for Integrated Disease-‐Related Research

q  Maintain and improve #1 ranking in Canada for basic life science research

q  Achieve global compe::veness in transla:onal research to clinic o  Raise $50M to pursue transla:onal research through personalized medicine

opportuni:es

q  Achieve global compe::veness in commercializa:on ac:vi:es o  At least 5 spinoffs and/or 5 technologies licensed out per year

4


What Have We Done So Far?

q  Maintain and improve #1 ranking in Canada for basic life science research o  Established Academic CommiEee o  New LSI website o  Omics Portal launched o  CFI applica:on under review

q  Achieve global compe::veness in transla:onal research to clinic o  Iden:fied 13 large Personalized Medicine projects

§  Business plans wriEen for 5 projects §  First two projects funded and ini:ated §  Funding discussions underway for two more projects

o  Molecular You -‐ Preven:ve Health project o  Personalized Medicine Summit June 7-‐9, 2015

§  Personalized Medicine White Paper

o  LSI Public Talks featuring Personalized Medicine projects

q  Achieve global compe::veness in commercializa:on ac:vi:es o  Ten startups incorporated; 4 more under development

5





opportuni:es


6


Academic Committee

q  Objec:ve: Maintain and improve #1 ranking in Canada for basic life science research

q  First Mee:ng: Dec 15, 2014

7


The LSI Student and Trainee Support Fund

q  Students and trainees are the common element to all LSI PIs

q  New dona:ons fund to support LSI students and trainees

q  Goal: $100,000

q  Raised to date: $ 17,500

q  Seeking further support internally and externally

q  Ques:ons: •  Leanne Denis (Medicine) •  John Andru (Science)

8





opportuni:es


9


Human Omics Will Inform Basic Life Science Research

10

Personalized Medicine Initiative

Database of Human Omics -‐genomics -‐proteomics

-‐metabolomics -‐microbiomics

-‐phenomics (clinical)

Empower & Inform Basic Sciences Research

Research @ LSI

Bacteriophage

Bacteria

Yeast

Worm

Fly

Zebrafish

Rodents

Understanding biology underlying disease

New diagnostics

New commercial opportunities

New therapeutics

Improved health Focused HQP training

Job Creation


LSI/PMI Translational Projects

Large collabora+ve projects with a personalized medicine theme that have the objec+ve of changing clinical prac+ce

Budgets > $2M per project over 4 years

Translational Projects:

q  Collaborate with clinician

q  Perform Omics (genomics, proteomics, metabolomics, microbiomic) analysis

q  Validate biomarkers for diagnosis and to guide treatment

q  Iden:fy biology behind biomarker; iden:fy new therapeu:c targets

11


The PMI/ LSI has Thirteen Personalized Medicine Projects That Aim To Change Clinical Practice

1.  Primary Care Pharmacogenomics 2.  Cancer Pharmacogenomics 3.  Au:sm Spectrum Disorders 4.  Diabetes 5.  Liver Fibrosis 6.  Microbiomics 7.  Cancer Immunotherapy 8.  Brain Health 9.  Cardiac Arrhythmias and Atrial Fibrilla:on 10. Ion Channel Molecular Structure Consor:um 11. Tuberculosis 12. Stroke 13. Sep:c Shock

12



13

Project LSI Lead Clinician Lead Objec+ve Budget

PGx in Family Prac:ce GenXys

Pieter Cullis Mar:n Dawes Use PGx to guide prescrip:on prac:ces $ 2.7M/

3yrs Cancer PGx Contextual Genomics

Pieter Cullis David Huntsman

Genetic tests to guide drug prescription for treatment of cancer

$ 2.1M/ 2yrs

iTARGET Au:sm Shernaz Bamji Suzanne Lewis

Early diagnos:c & individualized treatments for ASD

$ 12.3M/ 3yrs

Personalized Drugs for Diabetes Personalized Biomarkers Inc.

Tim Kieffer Tom Elliot

Iden:fy responders/ poten:al ADRs for GLP1 agonists

$ 3.2M/ 2yrs

Molecular Diagnos:cs for Liver Fibrosis FibroMDx

Francois Jean Mel Krajden

miRNA diagnos:c for stages of liver fibrosis

$ 4.3M/ 3yrs

Microbiome Insights Bill Mohn; Brett Finlay

Understand the role of the microbiome in health and disease

Cancer Immunotherapy Myeloid Enhancement Therapeutics

Ken Harder Development of immunotherapy for the treatment of cancer



14

Project LSI Lead Clinician Lead Objec+ve Budget

Brain Health Synaptitude Max Cynader Early detection and treatment of

dementia

PGX of Cardiac Arrhythmias and Atrial Fibrilla:on

Ed Conway, Eric Accili, Filip Van Petegem Jason Andrade, Andrew Krahn, Shubhayan Sanatani

Early detection and prevention of cardiac arrest due to genetic defects; Genetic biomarkers to guide drug therapies

Ion Channel Molecular Structure Consor:um

Filip Van Petegem, Calvin Yip

Determine the molecular structure of ion channels for drug discovery and development

$15M/ 5 years

Tuberculosis Lindsay El+s, Charles Thompson James Johnson (BCCDC)

Tailored treatments for TB and mycobaterial infections

Stroke Preven:on Chris+an Naus Andrew Penn

Validate biomarkers to prevent stroke subsequent to a TIA

PGx and sep:c shock Bob Hancock James Russell

Test before treating with antibiotics and other therapies for septic shock


How Are We Funding Large, Personalized Medicine Projects? Tac+cs: q  Iden:fy projects aimed at changing clinical prac:ce

o  Compelling unmet need o  Major economic benefit o  Appropriate exper:se available or accessible

q  Develop Business Plan to raise funds o  Iden:fy poten:al investors (gran:ng agencies, pharmaceu:cal companies,

philanthropy, government, healthcare, startups, venture) o  Assemble demonstrably excellent team o  Make scien:fic case and business/economic case

q  Design investor presenta:ons oriented to selected audiences

q  Engage poten:al investors

15


Example 1: PGx in Family Practice (P. Cullis & M. Dawes)

Budget: $ 2.7M / 3 yrs

q  Objec:ve: Develop clinical decision support system (CDSS) to guide prescrip:on prac:ces for ~ 120 commonly prescribed drugs o  21 SNP panel ($40 test, $100 w/ blood draw) o  3yr 6,000 pa:ents over 65 on 10 or more drugs (20% of 65yr + popula:on) o  Develop algorithms to use with EMR o  Benefits: reduced drug use reduced ADRs and emergency visits

q  Funding tac:cs o  Business plan (complete) o  Pitch to Rx&D Canada and Pharma, raise $760K from Rx&D; Pfizer, Merck, GSK,

Janssen, Roche, AstraZeneca; funds received) o  Secure matching funds ($180K Genome BC received) o  Form startup (GenXys), raise $ matching from investors, partners in process

Similar financing model: Cancer PGx to guide therapy ($750K commiOed from Pharma)

16


Example 2: iTARGET Autism (S. Bamji & S. Lewis)

Budget $ 12.3M / 3 yrs

q  Objec:ve: Develop diagnos:c for early detec:on and stra:fica:on of au:sm spectrum disorder o  WGS of 1500 pa:ents with ASD with complete medical history o  Complementary proteomic, metabolomic and microbiomic analyses o  Establish data repository and analysis capabili:es o  Product: Omic-‐based CDSS to diagnose and stra:fy ASD at birth o  Benefits: Early diagnosis > effec:ve interven:on with behavioural therapy

q  Funding tac:cs o  Business Plan (complete) o  Partner with: Genome BC ($1M in process); Pacific Au:sm Family Centre (PAFC)

to raise $4M (in process); commercial partner to store data (in process, $200K in kind support commiOed); UBC to raise $10M from philanthropic sources (in process); when complete approach BC Government for final $2M.

17


Preventive Medicine Project; Provide Standard Analyses for Healthy Participants

18

Rob Fraser


Preventive Medicine Project; Provide Standard Analyses for Healthy Participants

q  Improve and maintain health through early detec:on of disease using integrated Omics datasets o  Individualized, molecular level informa:on for preven:ve health and

personalized medicine applica:ons o  detect disease before it is serious o  select the right treatment at the right :me

q Establish database of longitudinal par:cipant molecular data o  Integrate with Ministry of Health Data o  New IP poten:al

19


genome: Whole genome sequence and analysis proteome: 192 blood proteins from blood spot metabolome: 100 lipid an small molecule metabolites from blood draw microbiome: 1000’s of gut microbes from stool sample phenome: Ac:vity and behavior monitoring and modifica:on

Personalized User Manual For Your Body

20


How Does it Work?

21

Present Practice

Molecular You


Integrated Human Omics Approach Provides Direction for Basic Life Sciences Research

Proven Approach

Basic Life Science Research

Expe

r&se fo

und @ LSI

Bacteriophage

Bacteria

Yeast

Worm

Fly

Zebrafish

Rodents

NHP

Human

22

Omics Approach

Human

Omics

Well People (Preven:ve Medicine)

Ill People (Disease cohorts)


How Are We Funding Molecular You Co ?

q  Objec:ve: Detec:on of biomarkers associated with early onset of disease o  Enroll 1000 by 2017, expand to 10,000 total by 2020 o  Par:cipants: Ini:al WGS and every 3 months perform proteomic, metabolomic

and microbiomic analyses, meet with healthcare professional for interpreta:on o  Incidental findings may benefit par:cipants; access to data will benefit LSI/UBC

researchers o  Establish “well oiled machine” to study disease cohorts in partnership with

healthcare system

q  Funding tac:cs o  Establish NewCo (Molecular You Corpora:on; MYCO) to enroll par:cipants at

cost ($10K 1st year, ~5K subsequent years) (Business Plan wriOen) o  Pitch to poten:al investors to raise $6M to finance MYCO in tranches $1M 2014

($250K commiOed); $2M 2015 and $3M 2016

23





opportuni:es


24


The PMI Has Initiated Ten Start-‐Ups With More in Development

NewCos incorporated since 2010

1.  Precision NanoSystems 2.  Acuitas 3.  MesenTech 4.  GenXys Health Care Systems 5.  Contextual Genomics 6.  MetaMixis 7.  PMI Personalized Medicine Ini:a:ve 8.  Microbiome Insights 9.  Personalized Biomarkers Inc 10.  Myeloid Enhancement Therapeu:cs

NewCos in Development: Molecular You Corp., Exomics RDx, FibroMDx, Synap:tude, Service Outreach, LSI Protocols

25


Personalized Medicine Summit and White Paper June 7-‐9, 2015

26

hOp://www.personalizedmedsummit.com/

Deliverable: White Paper to guide the implementa:on of molecular based medicine into the front lines of healthcare in BC and Canada


New LSI Website Launched (www.lsi.ubc.ca)

27

Neera Vohra


New LSI Website Launched (www.lsi.ubc.ca)

28

In line with the 3 main objective of LSI: • Maintain and improve #1 ranking in Canada for basic life science research

• Achieve global competitiveness in translational research to clinic • Achieve global competitiveness in commercialization activities

Targeted at key stakeholders – general public, government and research community with the objective of communicating how the various efforts being made at the LSI are impacting our community, economy and government decision making.


News & Events

29


Personalized Medicine Projects

30


Commercialization

31


Students and Post Docs

32


LSI Website – Next Steps

q  Con:nue making it relevant, regular updates to keep it current.

q  A dymanic sec:on called ‘A scien:st’s life’ – a page from the researchers for the researchers

q  Integrate Social Media

q  What do you want to see?

q  Comments at [email protected]

33


LSI Outreach and Omics Portal

Stefanie Butland

34


LSI Public Talks

35

Oct 8, 2014 – Au:sm Nov 26, 2014 – Diabetes Feb 4, 2015 – Molecular You Mar 25, 2015 – World TB Day


LSI Public Talks on Diabetes – Wed Nov 26, 6 PM

36

hOp://lsi.ubc.ca/talks


LSI Events

37

q  Nobel Laureate Venki Ramakrishnan – Sept 19

q  Geek Olympiad (LSI GSA) – Oct 10

q  Introduc:on to Intellectual Property – Nov 4

Upcoming Events

q  Nov 26 -‐ LSI Public Talks – Diabetes

q  Dec 11 -‐ FEI Cryo-‐TEM Workflow Solu:ons: A new era for 3D Structural Biology

q  Dec 5 – LSI Holiday Party


Omics Portal Launched

48 lis:ngs: services, training and online resources

38


Where is it?

39


What gets included?

Anything to enable research involving integrated Omics approaches o  Academic & commercial o  Local & remote o  Core facili:es, services, online resources, training and networking

opportuni:es

Name of resource, some tagged with o  URL o  Descrip:on o  Contact o  LSI Collaborators and Users/Recommended by

40


Ctrl-‐f “metabolomics”

41


Matchmaking – LSI + CS / Math / Stats / Physics

42

WEDNESDAY, DECEMBER 3, 12 PM FACULTY LOUNGE


LSI Academic

Kevin Lin

43


Academic Committee

q  Objec:ve: Maintain and improve #1 ranking in Canada for basic life science research

q  Members o  Shernaz Bamji o  Julian Davies o  Steven Hallam o  Tim Kieffer o  Jay Kizhakkedathu o  Don Moerman o  Robert Nabi o  Chris Overall o  Natalie Strynadka o  Catherine van Raamsdonk

q  First Mee:ng: Dec 15, 2014

44


LSI Strategic Grants Update

q  Awai+ng results for these grants submiOed in 2014:

o  CFI Innova:ons Fund (Playorm for Integrated Omics and Phenotyping) §  $16M in equipment §  $1.67M for opera:ons (over 5 years)

o  NSERC CREATE Applica:on (Ecosystem Services, Commercializa:on Playorms and Entrepreneurship)

§  $1.65M (over 6 years)

45


LSI Strategic Grants Update

q  Projects for 2015 submission:

o  Canada First Research Excellence Fund §  Nanomedicines Theme §  Approved by VPRI for UBC LOI stage (15/107 were selected) §  $50M available in inaugural year of award §  UBC likely submit 1 applica:on

o  NCE Centre for Commercializa:on and Research (CECR) §  Personalized Medicine Ini:a:ve (PMI) §  Nanomedicines & Drug Delivery Centre §  $15M/centre for 5 years (1:1 matching required) §  March 2015 LOI deadline

46

PARTY! FRIDAY, DEC 5, 4-‐7 PM FOOD, CASH BAR, TREE-‐TRIMMING, ROCK & ROLL!

THE LIFE$SCIENCES$ INSTITUTElsi-dev.sites.olt.ubc.ca/files/2014/11/LSI-All... ·...

Documents

Transcript of THE LIFE$SCIENCES$ INSTITUTElsi-dev.sites.olt.ubc.ca/files/2014/11/LSI-All... ·...