The Israeli Ministry of Health Chief Scientist Office Dr. Benny Leshem, Director The Medical...

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The Israeli Ministry of HealthThe Israeli Ministry of Health

Chief Scientist OfficeChief Scientist Office

Dr. Benny Leshem, DirectorDr. Benny Leshem, Director

The Medical Research The Medical Research AdministrationAdministration

The State of Israel

Ministry of Health

Chief Scientist Office

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The State of Israel

Ministry of Health


RESEARCHERRESEARCHER

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The State of Israel

Ministry of Health

Chief Scientist Office Who are the major players in the Israeli research funding arena?

Medical Research in Israel

Where in Israel medical research is done?

CSO-MOH, funding Program

Numbers and Facts on funding of medical research in Israel

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The State of Israel

Ministry of Health


Public Research Funds in Israel (2003)

International Funds (NIH, EC): 12.9 M €

Charity Based Funds: 2.1 M €

Bi-national Funds (BSF, GIF): 6.1 M €

Government Funds(MOE, MOST, MOCIL, MOH): 11.5 M €

32.6 M €


M HM Hcscs

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The State of Israel

Ministry of Health

Chief Scientist OfficeWho are the major players in the Israeli research funding arena?


Where in Israel Medical Research is done?


Numbers and Facts on funding of Medical Research in Israel

M HM HcscsOO

The State of Israel

Ministry of Health


Major Academic Institutes:Hebrew University*, JerusalemTel Aviv University*, Tel AvivBen Burion University*, Beer ShebaTechnion*, HaifaHaifa Universiry, Haifa The Bar Ilan University, Ramat GanThe Wiezmann Institute, Rehovot-------------------------------------------------

* Include Medical Schools


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The State of Israel

Ministry of Health


Major Medical Centers:

Hadassah*, JerusalemSheba*, Tel AvivSoraski*, Tel AvivRabin*, Petah TikvaSoroka*, Beer ShebaRambam*, Haifa--------------------------------------------------------------------------------------------------

* Affiliated to Medical Schools* Affiliated to Medical Schools


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The State of Israel

Ministry of Health






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The State of Israel

Ministry of Health


Scope: Medical Scope: Medical ResearchResearch (health and (health and disease linked)disease linked)

CSO-MOH: Chief Scientist Office, Ministry of Health

0.85 M € in 2003

3% of all the support to medical research in Israel


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Funding of Medical Research: CSO-MOHThe State of Israel

Ministry of Health

Chief Scientist OfficeRaison d’être

* To fills in the niche between Foundations supporting basic science

Bio-hitech enterprises supporting applied R&D and by that bridge on the gap and “process” the basic finding to be attractive to the Bio-hitech

* To foster and support medical research in

hospitals

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Ministry of Health

Chief Scientist OfficeFunding method :

Review method:

(NIH model)

Investigator-initiated (“Bottom-up”)

Study Sections (Review committees)

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Ministry of Health

Chief Scientist OfficeAnnual Call for Applications

( Depending on budget)

Research Projects*

Feasibility studies*

Fellowships to research-clinicians

* Grants do not cover salaries to PI and CI, allow 10% overhead

Stipends to Investigators-physicians (Research Protected Time)

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Ministry of Health

Chief Scientist OfficeEligibility

All researchers with Ph.D., M.D. or equivalent degrees

From any recognized research institute in Israel

On any field of medical (Health- and Disease-related) research

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Ministry of Health

Chief Scientist OfficeSubmission of Applications

Printed applications are mailed to CSO-MOH

Applications are submitted by Email

Application forms are submitted on-line

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Ministry of Health

Chief Scientist OfficeAdmission of Applications

Printed applications are also available for reviewers

Emailed files of applications are installed in a protected site in CSO-MOH server for on-line review

On-line submitted data are automatically integrated into CSO-MOH database

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Ministry of Health

Chief Scientist OfficeHandling of applications

Required data on applicants, budget,

Applications are checked for:

EligibilityRelevance to CSO-MOH scope of funding

Required Bio-ethical (Helsinki, Animal experimentation) and biohazard documentations

Applications are allocated to study sections by field of research

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Ministry of Health

Chief Scientist OfficeReview Committees (Study Sections)

Assigned Ad-hoc

Field expert reviewers (10% new reviewers)

Nominated chairpersons

Volunteers

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The State of Israel

Ministry of Health


We have read your proposal and are giving it serious consideration

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Ministry of Health

Chief Scientist OfficeReview Criteria

2. Significance and potential contribution to medicine (relevance to medicine in Israel - extra)

5. Application organization, personnel, budget

1. Scientific Merit (Hypothesis, Scientific Approach, Innovation)

4. The applicants and available facilities

3. The methods and their relevance to the aims, adequate biostatistics

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Ministry of Health

Chief Scientist OfficeAdditional Criteria

d) Encouraging multi-center (Academia-Hospital) collaboration

a) Encouraging investigators at the beginning of their scientific career

c) Encouraging research done in peripheral hospitals

b) Encouraging research done by clinicians

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The State of Israel

Ministry of Health

Chief Scientist OfficeENDANGERED SPECIES

MD-RESEARCHERSMD-RESEARCHERS

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Ministry of Health

Chief Scientist OfficeReview ProcessFifteen-twenty applications/committee

Each reviewer is assigned as a primary reviewer of 2-4 applications; Prepares written reviews.

Ten-fifteen reviewers/committee

Some applications may be sent to additional external reviewers, when special expertise is needed

Presentation of each application to the panel, 10-15 minutes discussion followed by scoring (0-100) and voting at a secret ballot

Applications are reviewed “as written”

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Ministry of Health

Chief Scientist OfficeSpecial Review Process

For those the procedure is a combination of external reviews and a study section

Applies for research areas to which less than 9 applications were received

The review committee consists of the members of CSO-MOH advisory board together with “Field

Coordinators”

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Ministry of Health

Chief Scientist OfficeFunding Decisions

Final decisions, based on scores and Chair’s recommendations, are made by the Fund’s board.

No appeals on final decisions

Applicants may receive (by request) the written reviews

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Ministry of Health

Chief Scientist OfficeReports

Financial reports: Semi-annually

Progress (final) Reports: Annually

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Ministry of Health

Chief Scientist OfficeFunding from Other Sources

CSO-MOH review and scientific follow-up mechanism is also provided to other funding organizations supporting medical research

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The State of Israel

Ministry of Health






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The State of Israel

Ministry of Health


CHIEF SCIENTISTCHIEF SCIENTIST

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The State of Israel

Ministry of Health


Funding of Medical Research: CSO-MOH

Funding 2001-2003

Average grant: 15,000 € p.a. for 2 years (not including salaries, allowing 10% overhead)

YearAppliedFunded% Funding

20012396225.9%

20023508223.4%

20032305423.5%

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The State of Israel

Ministry of Health


Funding of Medical Research: CSO-MOH

Funding 2002-2003 (PathoGenoMics-related)

YearAppliedTotal Funded

Success rate

)of Total(

In Infec.

Dis.

%

)of Total(

Funded in Infec.

Dis.

Success rate (%) (Infec. Dis.)

20023508223%288.0% 9 32%

20032305424% 166.9% 6 38%

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Ministry of Health

Chief Scientist OfficeResearch Projects: Pathgenomics-related

The role of human metapneumovirus in community- acquired respiratory tract infections in young children in Israel

Virulence determinants of group G streptococcus and emm typing of a collection of strains obtained from one hundred patients with bacteremia.

The potential use of newly isolated attenuated mutants of vaccinia virus as vaccine against smallpox

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Ministry of Health

Chief Scientist OfficeResearch Projects:

Virulence strategies of Salmonella enterica serotype Virchow: from the gene to the plate

Comparison of the virulence system required for intracellular multiplication by different pathogenic Legionella species

Proteomic assessment of genes involved in the development of the human pathogen Leishmania

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The State of Israel

Ministry of Health


[email protected]

Tel: +972-2-568-1208 ,

Cell: +972-50-624-2187

Fax: +972-672-5833

M HM Hcscs

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The State of Israel

Ministry of Health


מדינת ישראלמשרד הבריאות

המדען לשכתהראשי

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Hospitals

(Development & Production)

(Basic Research)

(Clinical

Research)

Industry

Academia

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The State of Israel

Ministry of Health

Chief Scientist OfficeBetter Medicine

Better Health

Longer and Healthier life

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The State of Israel

Ministry of Health


BSF GIF ISF MOH

Funding Agency

0

10

20

30

40

50

60Pe

rcen

tFunding of Hospitals

Applied

Funded

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Ministry of Health

Chief Scientist OfficeAfter the Meetings

Scores are averaged. (Significantly deviated scores - ignored)

Applications scored below 90 are not funded.

Applications scored above cut-off score are recommended for funding.

A cut-off score is proposed, based on available budget.

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Ministry of Health

Chief Scientist OfficeFunding Activation

Approval and rejection letters are sent to all applicants:

“Highly scored but not funded” letters to applications scored between 90 and cut-off*.

* May be beneficial for the applicants for promotion and institutional support

A legal contract is signed between CSO-MOH, institution’s research authority and PI

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