The Institutional Animal Care and Use Committee
description
Transcript of The Institutional Animal Care and Use Committee
what we do for animal research at ASU
The ASU Animal Use Program
A three-legged stool
Institutional Official- Jon Harrison
Institutional Animal Care & Use Committee
Chair – Dale DeNardo
Attending Veterinarian
(& DACT Director)- Joanne Tetens
Institutional Animal Care and Use Committee (IACUC)
The IACUC provides internal oversight of animals used in research & teaching:
- animal use procedures
- husbandry
- facilities
The ASU IACUC consists of 11 voting members plus other supporting participants who include:
- faculty representing the various departments and uses of animals
- representatives of relevant ASU service units- DACT (including the Attending Vet)- Environmental Health & Safety- Campus Health- Risk Management- Office of Knowledge Enterprise
Development Office
- non-affiliated member
http://researchintegrity.asu.edu/animals/IACUC+Overview
Institutional Animal Care and Use Committee (IACUC)
Web site includes:- IACUC Policies and Procedures Manual - IACUC forms- protocol due dates & meeting dates- IACUC training instructions and exams- IACUC Standard Institutional Guidelines- AVMA euthanasia guidelines- professional society non-traditional species recommendations- federal regulations and other policies- Animal Welfare Assurance & USDA certificate numbers- Occupational Health & Safety Program documents- DACT forms & housing per diem rates- etc.
Primary objective - oversight
To assure that ASU meets all regulatory requirements
- USDA – enforces the Animal Welfare Act. Definition of “animal”?
- OLAW (Office of Laboratory Animal Welfare) – oversees the use of non-human vertebrates in PHS-supported research or included in the institution’s PHS assurance (PHS Policy on Humane Care and Use of Laboratory Animals, 2002)
- AAALACi (Association for the Assessment & Accreditation of Laboratory Animal Care International) – voluntary, covers all non-human vertebrates at the institution
- U.S. Fish & Wildlife Service – oversees federally protected species, migratory birds, and international transport of all vertebrate animals and their parts
- Arizona Game & Fish Department – oversees the capture & holding of native wildlife, as well as the holding of restricted non-native wildlife
- Arizona Department of Health Services – covers species where there is a concern for zoonotic disease
Institutional Animal Care and Use Committee (IACUC)
Next tri-annual visit is this winter!
All mammals except laboratory mice & rats
Institutional Animal Care and Use Committee (IACUC)
Secondary objective - service
To minimize the burden on investigators (provided it does not interfere with Objective 1)
- Assist investigators in achieving compliance.
- Develop processes that are consistent but flexible enough to be relevant to the varied animal use on campus.
- Eliminate the need for duplication of effort by investigators (e.g., sharing of protocols across institutions)
Institutional Animal Care and Use Committee (IACUC)
The review process (detailed in the Policies & Procedures Manual):
Protocols:- pre-reviewed by the Attending Veterinarian, then one other IACUC member (assigned by the Chair as the Primary Reviewer)
- reviewed by the full committee at a convened meeting in the presence of the PI or designee
Amendments:- Minor – administratively approved by the Chair
- Significant – with the approval of the full committee, reviewed by a Designated Reviewer (assigned by the Chair) and the Attending Veterinarian
- Major – reviewed by full committee at a convened meeting
- the rationale for the new procedure is consistent with the research goals in the approved protocol
- involves no increased risk of pain, distress, or discomfort to animals
- does not markedly increase, by absolute or relative terms, the number of animals involved in the project
- a change that does not affect the animals (e.g., adding personnel)
- any change deemed substantive by the Chair or any IACUC member
Protocol Form
- regulatory oversight is very dynamic (if the rules change, the form must change)
- improve comprehension of the questions (the better the question, the more likely we get the info we need)
- improve internal logistics (to ease reporting)
Why does the protocol form change periodically?
MAKE SURE TO USE THE MOST CURRENT FORM! (available on the web site)