The Gazette -- January 4, 2010

766

our 39th year

Covering Homewood, East Baltimore, Peabody,

SAIS, APL and other campuses throughout the

Baltimore-Washington area and abroad, since 1971.

January 4, 2010 the newspaper of the Johns hopkins university Volume 39 No. 16

Job Opportunities

Notices

Classifieds

arra reSearCh

Cell biologist’s progeria study

could shed light on the normal

aging process, page 4

ForMer PreSIDeNt DIeS

Lincoln Gordon, under whom

the Homewood schools became

co-ed, has died at 96, page 3

I N B r I e F

Record number of early applicants; White

House nomination; tech commercialization

C a L e N D a r

Seminars in cell biology, biochemistry and

molecular biology, embryology, neuroscience2 8

A treasure comes home H O M E W O O D

Seven from JHU named AAAS fellowsB y A u d r e y H u A n g

Johns Hopkins Medicine

Seven Johns Hopkins researchers from four of the university’s schools have been elected by their peers as

fellows of the American Association for the Advancement of Science. Pierre A. Coulombe and Marcelo

Jacobs-Lorena of the Bloomberg School of Public Health, David Draper of the Krieger School of Arts and Sciences, David J. Linden and Cynthia Wolberger of the School of Medicine and Peter C. Sear-son and Denis Wirtz

of the Whiting School of Engineering are among 531 new fellows around the world. Election as a fellow honors scien-tifically or socially distinguished efforts to advance science or its applications. This year’s AAAS fellows were announced Dec. 18 in the “AAAS News & Notes” section of the journal Science. New fellows will be presented with an official certificate and a gold and blue (representing science and engineering, respectively) rosette pin on Saturday, Feb. 20, during the 2010 AAAS Annual Meeting in San Diego. AAAS is an international nonprofit organization dedicated to advancing sci-ence around the world. As part of the section on biological sciences, Pierre A. Coulombe, the E.V. McCollum Professor and Chair of the Department of Biochemistry and Molec-ular Biology at the Bloomberg School of Public Health, was elected for his studies on the role of differential keratin expres-sion in the architecture, function and homeostasis of epithelial tissues. Coulombe’s research focuses primarily on the keratin filament cytoskeleton in epithelial cells, with an emphasis on skin tissue. He is working to gain a bet-ter understanding of various key func-tions of keratin proteins, and keratin filaments, at a cellular and molecular

researchers

elected are

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Continued on page 5

K U D O S

Sonneborn Collection of Judaica to be used for research and teaching

B y g r e g r i e n z i

The Gazette

Dozens of Jewish ceremonial pieces, most of them silver, had been dispersed in Baltimore and were recently returned to Johns hopkins, where they are housed in the Smokler Center for Jewish Life. at right, hillel director rabbi Debbie Pine.

Nanoparticles bypass mucus barrier, may deliver drugs R E S E A R C H

Continued on page 6

B y M A r y S p i r o

Institute for NanoBioTechnology

Johns Hopkins University researchers have created biodegradable nanosized particles that can easily slip through the

body’s sticky and viscous mucus secretions to deliver a sustained-release medication cargo. The researchers say that these nanoparticles, which degrade over time into harmless com-ponents, could one day carry life-saving drugs to patients suffering from dozens of

health conditions, including diseases of the eye, lung, gut or female reproductive tract. The mucus-penetrating biodegradable nanoparticles were developed by an interdis-ciplinary team led by Justin Hanes, a profes-sor of chemical and biomolecular engineer-ing in Johns Hopkins’ Whiting School of Engineering. The team’s work was reported recently in the Proceedings of the National Academy of Sciences. Hanes’ collaborators included cystic fibrosis expert Pamela Zeit-lin, a professor of pediatrics at the Johns Hopkins School of Medicine and director

of Pediatric Pulmonary Medicine at Johns Hopkins Children’s Center. These nanoparticles, Zeitlin said, could be an ideal means of delivering drugs to peo-ple with cystic fibrosis, a disease that kills children and adults by altering the mucus barriers in the lung and gut. “Cystic fibrosis mucus is notoriously thick and sticky and represents a huge barrier to aerosolized drug delivery,” she said. “In our study, the nano-particles were engineered to travel through

Continued on page 8

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In 1900, Baltimore clothing magnate Henry Sonneborn gifted to Johns Hopkins a work-in-progress collection of Jewish ceremonial pieces, includ-ing various early-19th-century silver

plates, spice boxes and Torah breastplates. With the assistance of two professors from the university’s Oriental Seminary Depart-ment, Sonneborn would over the next five

years acquire more objects and assemble the first private collection of its kind in the United States. Sonneborn wanted the approximately 95 objects to be used for research and teaching at the university, and put on display for the public. Johns Hopkins

2 THE GAZETTE • January 4, 2010

I N B R I E F

e d i t o r Lois Perschetz

W r i t e r Greg Rienzi

pr o d u c t i o n Lynna Bright

co p y ed i t o r Ann Stiller

pH o t o g r A p H y Homewood Photography

Ad v e rt i S i n g The Gazelle Group

Bu S i n e S S Dianne MacLeod

ci r c u l At i o n Lynette Floyd

We B M A S t e r Tim Windsor

Applied Physics Laboratory Michael Buckley, Paulette CampbellBloomberg School of Public Health Tim Parsons, Natalie Wood-WrightCarey Business School Andrew BlumbergHomewoodLisa De Nike, Amy Lunday, Dennis O’Shea,Tracey A. Reeves, Phil SneidermanJohns Hopkins MedicineChristen Brownlee, Stephanie Desmon, Audrey Huang, John Lazarou, David March, Katerina Pesheva, Vanessa Wasta,Maryalice YakutchikPeabody Institute Richard SeldenSAIS Felisa Neuringer KlubesSchool of Education James Campbell, Theresa NortonSchool of Nursing Kelly Brooks-StaubUniversity Libraries and Museums Brian Shields, Heather Egan Stalfort

c o n t r i B u t i n g W r i t e r S

The Gazette is published weekly Sept-ember through May and biweekly June through August for the Johns Hopkins University community by the Office of Government, Community and Public Affairs, Suite 540, 901 S. Bond St., Baltimore, MD 21231, in cooperation with all university divisions. Subscrip-tions are $26 per year. Deadline for calendar items, notices and classifieds (free to JHU faculty, staff and students) is noon Monday, one week prior to publication date.

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Record numbers apply early decision to Johns Hopkins

The Office of Undergraduate Admis-sions recently sent out early decision acceptance letters and e-mails to 494

students, choosing the first members of the class of 2013 from the largest early decision applicant pool in the university’s history. The record number of applications, 1,155, was up more than 10 percent from last year, and Johns Hopkins’ early decision applica-tions have increased 138 percent over the past decade, according to John Latting, dean of undergraduate admissions. The previous record number was 1,055 in 2007. The 494 students come from 36 states and 18 countries. The number includes three Baltimore Scholars. Two-thirds will attend the School of Arts and Sciences and one-third the School of Engineering. The anticipated incoming class size is 1,235. Latting said that the high number of early decision applications is due in part to high school students and their families increas-ingly thinking strategically about the admis-sion process and completing their college searches early. The School of Nursing also reported a huge surge in early decision applications this year for its accelerated (13-month) nursing program. The 47 percent increase from last year was attributed to the growing interest in the field and a recent Gallup Poll that made nursing the most trusted profession in the country for the eighth consecutive year. Preliminary data from the Association of Colleges of Nursing show an overall 3.5 per-cent increase in nursing school enrollments nationwide.

Carey Business School plans tech commercialization program

Starting in February, the Johns Hopkins Carey Business School will be offer-ing at the university’s Montgomery

County Campus a new technology commer-cialization program titled Innovate! Funded by a National Science Foundation grant to Johns Hopkins and the University of Maryland Baltimore County, Innovate! is a 12-month program led by successful serial entrepreneurs that will take a class of 15 business professionals and 15 postdoctoral fellows through evaluation of a technol-ogy’s commercial viability, preparation of a business case based on the technology and launch of the business. The businesses will be based on technology from the National Institutes of Health, Johns Hopkins, the University System of Maryland and other research institutions and federal agencies. “The Innovate! program is perfect for professionals who have thought about start-ing their own technology company and are looking for a supportive, structured environ-ment to help make it happen,” said Yash Gupta, dean of the Carey Business School. Elaine Amir, executive director of the

Montgomery County Campus, said, “We’re extremely excited to have the Innovate! program on our campus because it fits so well with the county’s economic develop-ment goals. The county recently released its Biosciences Task Force report, and one of its five key objectives was to ‘enhance the environment for entrepreneurship and the creation of new life sciences companies,’ ” she said. “It’s great that Johns Hopkins can help advance that goal.” Innovate! is based on the ACTiVATE program at UMBC, which has led to the formation of more than 25 companies since its inception in 2005. Partners for Innovate! include Rockville Economic Development, the Montgomery County Department of Economic Development and NIH. An information session about the pro-gram will be held from 6:30 to 8:30 p.m. on Thursday, Jan. 7, in Gilchrist Hall on the Montgomery County Campus. To attend, contact Robin Ferrier at 301-315-2896 or [email protected].

Gwen Boyd of APL to receive nomination by Obama

The White House has announced that President Barack Obama intends to nominate Gwen Boyd of Johns Hop-

kins’ Applied Physics Laboratory to the board of trustees of the Barry Goldwater Scholarship and Excellence in Education Foundation. Commenting on her nomination and those of nine others to different entities, Obama said, “I am grateful that these fine individuals have chosen to serve in my administration. They will bring a depth of experience and valued perspective to their roles, and I look forward to working with them in the months and years ahead.” The Barry Goldwater Scholarship and Excellence in Education Foundation, estab-lished in 1986 to honor the former U.S. senator and 1964 presidential candidate, awards scholarships to high-achieving col-lege students seeking careers in science, engineering and mathematics. Boyd, an engineer, is executive assistant to the chief of staff at APL and chair of the Johns Hopkins Institutions’ Diversity Lead-ership Council. She majored in mathematics at Alabama State University, with minors in physics and music, and was the first Afri-can-American to earn a master’s degree in mechanical engineering from Yale. She also received a master of divinity degree from Howard University and honorary doctor-ates from Bennett College for Women and Lincoln University. A prominent advocate for women’s equality and for the recruitment of African-Americans into science and engi-neering, she has received the 1996 Black Engineer of the Year Public Service Award, congressional citations and recognition by U.S. Black Engineer magazine as one of the nation’s “Most Distinguished Black College and University Graduates.”

B y d e n n i S o ’ S H e A

Homewood

Johns Hopkins has entered into a contract to acquire the former Zurich Insurance Co. property in north Baltimore and will

use it to consolidate financial, data process-ing and administrative functions currently spread out in a number of area locations. The property will be acquired by a sub-sidiary jointly owned by The Johns Hopkins University and Johns Hopkins Health Sys-tem. The 415,000 square feet of usable space in two buildings on the site—with large, open floors and two data centers—make it ideal for housing financial services and informa-tion technology operations, said James T.

McGill, the university’s senior vice presi-dent for finance and administration. The property, which includes 1,500 park-ing spaces, a cafeteria and meeting and classroom space, is at 40th Street and Kes-wick Road, less than a half-mile from the university’s Homewood campus. “The property’s location, layout, infra-structure and amenities made it a very attractive facility for both Johns Hopkins institutions,” McGill said. Ronald Werthman, vice president for finance of the Johns Hopkins Health Sys-tem, said, “The more we looked at both our future needs and what we’re paying now to operate in leased and owned space throughout the metro area, the clearer it became that buying this property made good economic sense for both entities.” The units that will move to the site have not all been identified. The buildings will be filled with Johns Hopkins tenants over time, as leases elsewhere expire and as other business considerations dictate. The university and health system, though they are separate corporations, have com-bined seven large back-office operations such as purchasing and accounts payable and receivable into what they call “shared ser-vices centers” that serve both entities. Some of those centers, which work together on a daily basis, are prime candidates for reloca-tion to the Zurich property. So are other still-separate university and health system offices that often collaborate. Johns Hopkins information technol-ogy functions are run by an organization called IT@Johns Hopkins that also crosses the lines between the two corporations. Some IT@Johns Hopkins groups, particu-larly those supporting business functions, are candidates for the Zurich property, though Johns Hopkins will continue to operate data centers elsewhere. The sale is scheduled to close March 31.

Johns Hopkins to buy former Zurich Insurance property

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Since Dec. 24, 1973, the 100th anniversary of the death of Johns Hopkins, members of the uni-versity and hospital communities that bear his name have gathered

at his simple grave site in Green Mount Cemetery to remember the generosity of their benefactor. Joined at the brief, infor-mal ceremony by appreciative members of the public, the assembled hear a few words from a Hopkins family member, historian or other expert; sometimes offer observations of their own; and traditionally leave pennies on his tombstone while saying thanks and making a wish. At this year’s Christmas Eve day service,

which fell after the season’s first big snowfall, attendees lined a cleared road to hear from Matt Crenson, professor emeritus of political science and faculty director of the univer-sity’s Baltimore Scholars Program, about what Baltimore was like circa 1873. At the time of Johns Hopkins’ death, his $7 million estate—which was to be divided in equal parts to establish a university and a hospital—was the largest philanthropic bequest in U.S. history. In the ensuing years, his beneficence has literally changed the lives of millions. To read his obituary from the Dec. 25, 1873, edition of The Baltimore Sun, go to www.jhu.edu/125th/links/obit.html.

An enduring tradition

January 4, 2010 • THE GAZETTE 3

Lincoln Gordon, who served as president of The Johns Hopkins University for four tumultuous years, died in his sleep on Dec. 19 at an assisted-living community

in Mitchellville, Md. He was 96. Gordon, a diplomat under Presidents Ken-nedy and Johnson who had also been on the faculty at Harvard, came to Johns Hopkins in July 1967, following the retirement of Milton S. Eisenhower. A gentleman of the old school, described by those who knew him as courteous and engaging, Gordon was rarely seen without his pipe. He loved to talk, between puffs on his pipe, and he dominated meetings with his lengthy conversations. His lasting legacy came as a result of a recommendation in 1969 from a student/faculty/administration committee, headed by Biology Professor Carl Swanson, that the all-male Johns Hopkins undergraduate program become coeducational. The first female students arrived at Homewood in 1970. But his tenure at the helm of Johns Hop-kins is remembered by many just as much for its marked difficulties. “Gordon had come to the university at a time of increasing unrest on college campuses throughout the country,” remem-

bers Vice President and Secretary Emeritus Ross Jones, who served under Gordon as vice president for public affairs. “Issues surrounding the war in Vietnam, racial jus-tice, individual rights and others stirred up students, faculty and administrators. And

JHU President Lincoln Gordon, 96,brought co-education to Homewood

O B I T U A R Y

although he had been ambassador to Brazil for five years, he had no experience as an administrator of a complex institution like Johns Hopkins, and he found the assign-ment very difficult.” Financial deficits increased dramatically during Gordon’s tenure, students were pro-testing about domestic and world issues, and the faculty was restless. Finally, in March 1971, some key members of the faculty vis-ited Gordon in his office, located in what is now Homewood Museum, and told him that they had lost confidence in him. Imme-diately they went downtown to the office of Robert D.H. Harvey, chair of the university’s board of trustees, and told him of their feel-ings about the president. Gordon resigned immediately, less than four years after his presidency had begun. One person to whom the news came as a surprise was Steven Muller, whom Gor-don had recently appointed, with trustee approval, as provost. Muller, then vice presi-dent for public affairs at Cornell University, had driven to Baltimore that day with his wife, Margie, and two daughters from their home in Ithaca, N.Y., to show his fam-ily the university and look for housing. The Mullers left the girls briefly at their motel, and, to their amazement, when they returned, the girls told them that they had

Lincoln Gordon in 1970

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B y A M y l u n d A y

Homewood

The American Academy in Rome recently named as its director Christopher Celenza, a profes-sor in the Department of Ger-man and Romance Languages

and Literatures and director of the Singleton Center for the Study of Pre-Modern Europe, both in Johns Hopkins’ Krieger School of Arts and Sciences. Celenza’s three-year term will begin in July, and he will return to his posts at Homewood upon its conclusion. Celenza will be the 21st director of the 115-year-old academy, one of the leading American overseas centers for independent study and advanced research in the fine arts and the humanities. “I am honored to be able to serve the American Academy in Rome, an institu-tion I, like many others, deeply admire,” Celenza said in an announcement from the academy. “Its integration of the arts and humanities, its central place in what has long been one of the most cosmopolitan cities in the world and its rich tradition of fostering the work of Americans abroad fill me with inspiration.” The directorship will be Celenza’s third tour with the American Academy in Rome. He was a Rome Prize Fellow from 1993 to 1994, and he served as director of its Sum-mer Program in Applied Palaeography from 2002 to 2005. He said he knows firsthand the influence the academy can have on a scholar. “My own fellowship year changed my life. It helped form not only the scholar that I am but also the person,” Celenza said. “For these and many more reasons, I am delighted to return. I look forward to continuing the work of the directors who have come before me; to collaborating with the academy’s president, Adele Chatfield-Taylor, and its outstanding trustees; and to working with the academy’s staff in Rome and New York, all toward the shared end of helping this wonderfully unique community continue to thrive.”

“This is a wonderful and well-deserved honor for Professor Celenza,” said David Bell, dean of faculty in the Krieger School. “I’m delighted that such a distinguished member of our faculty will be taking over the American Academy in Rome.” A historian and Latinist who studies Euro-pean intellectual history, Celenza holds two doctorates: in history, from Duke University, and in classics and neo-Latin literature, from the University of Hamburg. He has authored a number of articles and books, includ-ing The Lost Italian Renaissance: Humanists, Historians and Latin’s Legacy, published in 2005 by Johns Hopkins University Press. The book won the Renaissance Society of America’s 2005 Phyllis Goodhart Gordan Prize, and in 2006 it was issued in paper-back and selected as a CHOICE Outstand-ing Academic Title. Celenza holds second-ary appointments in History, Classics and the Humanities Center, all in the Krieger School of Arts and Sciences.

JHU prof to head American Academy in Rome Celenza has held many fellowships, including those from the American Council of Learned Societies (the Burkhardt Fellow-ship for Recently Tenured Scholars, 2003 to 2004); Villa I Tatti, the Harvard University Center for Italian Renaissance Studies (1999 to 2000); the Fulbright Foundation (1992 to 1993); and the John Simon Guggenheim Memorial Foundation (2008 to 2009). He is also active in the Renaissance Society of America. The resources of the American Acad-emy in Rome include a library of history, archaeology and art of Rome and of Italy; a photographic archive; and an archaeologi-cal study collection. The academy publishes Memoirs of the American Academy in Rome, an annual journal containing articles on classical studies, archaeology, art history and Italian cultural and historical studies from the Middle Ages to the present. Academy events include concerts, symposia, readings and exhibitions, which take place in Rome and the United States and are open to the public. Chatfield-Taylor, the academy’s presi-dent, said that Celenza will bring wonderful breadth and vigor to his new role. “He is enormously intelligent, with a wide-rang-ing understanding of European history and great warmth and generosity as a person,” she said.

Christopher Celenza, a professor in the Department of German and romance Languages and Literatures, will head the american academy in rome for three years.

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A P P O I N T M E N T

seen on the evening news that Gordon had resigned. The trustees coaxed Eisenhower out of retirement to serve as interim presi-dent, and then, 10 months after Muller took up his post as provost, named him to succeed Gordon. Abraham Lincoln Gordon, who never used his first name, was born on Sept. 10, 1913, in New York, where he was educated at the Ethical Culture Fieldston School in Riverdale, and later graduated with high honors from Harvard and earned his doctor-ate at Oxford. In a career that spanned the worlds of academia and government, Gordon spent 25 years on the faculty of Harvard, where he taught classes on government and interna-tional economics; was a high-level adminis-trator of Marshall Plan programs in Europe following WWII; and served as ambassador to Brazil. He also was a White House economic adviser to Ambassador W. Aver-ell Harriman, assistant secretary of state for Inter-American Affairs, a fellow at the Woodrow Wilson International Center for Scholars, an economist at the Brookings Institution and the author of numerous books. His wife, the former Allison Wright, died in 1987. He is survived by two sons, two daughters, seven grandchildren and two great-grandchildren. More about Gordon’s career can be found in obituaries in The New York Times (www .nytimes.com/2009/12/21/us/21GORDON .html?), The Washington Post (www .washingtonpost.com/wp-dyn/content/article/2009/12/21/AR2009122103466 .html) and The Baltimore Sun (www .baltimoresun.com/news/obituaries/bal-md .ob.ci.gordon22dec22,0,5482308.story).

Snow day?The fastest and most accurate source for Johns Hopkins snow

closings and other weather emergency information at the

university is the weather emergency phone line.

Call 410-516-7781 or, from areas where Baltimore is a long-distance

call, 800-548-9004. The sameinformation is also posted online at:

webapps.jhu.edu/emergencynotices


B y l i S A d e n i k e

Homewood

Susan Michaelis conducts her research in a traditional laboratory, with bea-kers and flasks and microscopes strong

enough to allow her to view and manipulate the infinitesimally small nuclei of cells. Even so, the living, breathing human beings that stand to benefit from this Johns Hopkins scientist’s work are never far from her mind. Michaelis’ research is dedicated to finding the causes of and treatments for a disorder known as Hutchinson-Gilford progeria syn-drome, or HGPS, commonly called progeria. Children born with progeria seem normal at birth, but by the time they reach their first birthday, they begin to age at a shockingly rapid rate. By the time they are 8 or 9 years old, these children resemble old people and suffer from a host of problems that normally afflict the elderly, including joint and bone difficulties, loss of hair and body fat, and cardiovascular issues. According to Michae-lis, by the time they reach 13, most children with progeria die of blood vessel disorders. Every few years, Michaelis has the oppor-tunity to meet and mingle with children

with progeria and their parents at a meet-ing sponsored by the National Institutes of Health and the Progeria Research Founda-tion, the leading research and advocacy group for the disease.

Unlocking the key to premature aging in children

“It’s been very motivating for me and the individuals who work in my laboratory to meet children with this disease and to hear what it is like to live with,” said Michaelis, a professor of cell biology in the School of Medicine. “These children are quite amaz-ing. On one hand, they are just ordinary,

delightful children. But on the other, they are unusually wise, thoughtful and mature. There is something uniquely compelling and inspiring about them, probably due

to the fact that they have to confront their mortality in a way that most of us don’t.” Using a $325,000 National Institutes of Health grant supplement, administered by the federal stimulus act, Michaelis and her team are working hard to unlock the secrets of this disease that afflicts more than 50 chil-dren in 30 countries. Specifically, Michaelis is investigating the role that a protein known as lamin A plays in the disease. Michaelis’ investigations are among the more than 300 stimulus-funded research grants and supplements totaling more than $157.4 million that Johns Hopkins has gar-nered since Congress passed the American Recovery and Reinvestment Act of 2009 (informally known by the acronym ARRA), bestowing the National Institutes of Health

and the National Science Foundation with $12.4 billion in extra money to underwrite research grants by September 2010. The stim-ulus package—which provided $550 billion in new spending, including the above grants—is part of the federal government’s attempt to bring back a stumbling economy by doling out dollars for transportation projects, infra-structure building, the development of new energy sources and job creation, and financing research that will benefit humankind. Johns Hopkins scientists have submitted about 1,300 proposals for stimulus-funded investigations, ranging from strategies to help recovering addicts stay sober and the role that certain proteins play in the devel-opment of muscular dystrophy to mouse studies seeking to understand how men and women differ in their response to the influ-enza virus. The subject of Michaelis’ grant, lamin A, is a protein found in the cell’s nucleus. For years, it was thought that lamin A’s only role was to give the nucleus structural support, in the same way that chicken wire would support a papier-mache sculpture. A decade ago, however, it became evident that mutant forms of the lamin A protein were implicated in a number of diseases, includ-ing muscular dystrophies, cardiomyopathies, neuropathies and progeria. “Our goal is to figure out how mutated forms of lamin A, particularly the lamin A variant that causes progeria, can exert dif-ferent effects from normal lamin A. Is it by regulating the expression of specific genes in specific cell types? We don’t know, but we are going to find out,” Michaelis said. The results of Michaelis’ team’s study not only could provide the basis for new therapeu-tic interventions against progeria and other lamin A–implicated diseases but also could shed light on the normal aging process. “Understanding the cellular and molecu-lar basis for the premature aging disor-der progeria may provide us with a better understanding of the normal aging process and ultimately lead to drug treatments that improve the normal aging process,” she said. “In the long run, the research we are doing could provide important benefits to the health of the human population at large.”

This is part of an occasional series on Johns Hop-kins research funded by the American Recovery and Reinvestment Act of 2009. If you have a study you would like to be considered for inclu-sion, contact Lisa De Nike at [email protected].

Working with postdoctoral fellow Jemima Barrowman, Susan Michaelis, a professor of cell biology, looks at a film of a gel analyzing the presence or absence of lamin a.

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A R R A R E S E A R C H

Johns Hopkins University recently unveiled a new Web site to showcase how research funding made available

in the American Recovery and Reinvest-ment Act of 2009 is being put to work on our campuses. The site, http://web.jhu.edu/economic _stimulus/index.html, includes a listing of all ARRA-funded grants received by university faculty as well as information on the economic impact and stories on some of the more than 300 projects that have been funded to date. “As the national economy emerges from the recession and we look toward future federal budgets, we feel it is critical to keep both policy-makers and the public informed about how JHU is making use of ARRA dollars,” said Tom Lewis, interim

vice president for government, commu-nity and public affairs. As the nation’s leading research insti-tution with more than $1.6 billion in annual research and development spend-ing, according to the most recent data from the National Science Foundation, Johns Hopkins was well-positioned to take advan-tage of the unprecedented influx of research funding made available through ARRA. To date, Johns Hopkins faculty have received nearly $160 million in ARRA funds from the National Institutes of Health and the National Science Foundation, which will be expended over two years. The Web site will be updated peri-odically to reflect additional awards and to highlight some of the research being undertaken with ARRA dollars.

JHU’s use of ARRA funding showcased in new Web site

The first Biomedical Engineering Undergraduate Research Day was conducted last semester on the

Homewood campus to showcase and judge student research projects. Sixteen biomedi-cal engineering undergraduates submitted abstracts and posters focusing on research they had conducted during the past year. Faculty members judged the posters and selected four finalists, who offered oral pre-sentations about their work. The judges then chose the top award winners. The first-place honor went to freshman Daniel Peng for “Engineering Thermorevers-ible Hydrogels for Controlled Drug Deliv-ery.” Peng also received the Students’ Choice Award, as voted by the freshman class, for his poster.

In second place was junior Joseph Heng for “Hierarchical Processing of Temporal Envelope and Fine Structure Information in Cochlear Implant-Mediated Perception of Musical Timbre.” Third place went to junior Nicholas Tan for “An Empirical Model That Predicts the Effects of PGC-1α and HIF-1α on VEGF Distribution in Skeletal Muscle Tissue.” The honorable mention recipient was senior Carolyn Park for “The Role of Ven-tricular Geometry in Arrhythmogenesis Under Brugada Syndrome.” Elliot McVeigh, director of Biomedical Engi-neering, presented certificates to the four final-ists. The top three students also received mon-etary awards that will cover partial expenses to a national scientific research conference.

BME holds first Undergraduate Research Day

The first-ever published study of aviation-related injuries and deaths in the United States finds that an

average of 1,013 patients are admitted to U.S. hospitals with aviation-related injuries annually, and that an average of 753 avia-tion deaths occur each year. The study, conducted by researchers from

the Johns Hopkins Bloomberg School of Public Health’s Center for Injury Research and Policy and from Columbia University, also reports that the largest categories of patients were occupants of civilian, non-commercial powered aircraft (32 percent) and parachutists (29 percent). For both groups, lower limb fractures were most

1,000-plus admitted in U.S. annually for aviation-related injuriescommon, encompassing 27 percent of all hospitalized injuries. While burns were seen in only 2.5 percent of the patients, they were responsible for 13 percent of the deaths. The report is published in the December issue of Aviation, Space and Envi-ronmental Medicine. “Our findings provide valuable infor-mation, not previously available, on the number and kinds of injuries sustained in aviation-related events,” said lead author Susan P. Baker, a professor with the Injury Center. “Because many injuries can be pre-vented through changes in the structure of aircraft, these data should be used to recog-nize needed improvements in aircraft design. For example, the high numbers of lower limb fractures suggest modifications should be considered to the various structures likely to be contacted by the feet and legs when a crash occurs.” The researchers analyzed data from the nationwide inpatient sample known as NIS, a data system sponsored by the Agency for Healthcare Research and Quality that contains information for approximately 20 percent of all hospital admissions in the United States. Using the International Clas-sification of Diseases, ninth edition, codes for air transport accidents were used to

identify patients who were hospitalized for aviation-related injuries during 2000–2005; aviation-related deaths were identified using International Classification of Diseases, 10th edition. The distribution of aviation injuries was calculated by victim type, discharge status and length of stay. “Unlike the highly effective surveillance system for all aviation crashes and inci-dents in the military, there is no formal injury reporting structure for civil avia-tion crashes,” said Dennis F. Shanahan, an adjunct faculty member with the Bloomberg School’s Department of Health Policy and Management. “Consequently, it is difficult to identify problems in particular aircraft or to estimate the feasibility of proposed improvements. It is our strong recommen-dation that a group such as the National Transportation Safety Board or FAA [Fed-eral Aviation Administration] establish a program modeled after the military or the reporting system of the National Highway Traffic Safety Administration so we can ultimately reduce the number of aviation-related injuries and deaths.” The research was funded by grants from the Centers for Disease Control and Preven-tion to the Johns Hopkins Center for Injury Research and Policy. —Tim Parsons


Pierre a. Coulombe, SPh David Draper, KSaS Marcelo Jacobs-Lorena, SPhPeter C. Searson, WSe

Denis Wirtz, WSeCynthia Wolberger, SoM

Related Web sitesJohns hopkins Bloomberg School of Public health: www.jhsph.edu

Johns hopkins KriegerSchool of arts and Sciences: http://krieger.jhu.edu

Johns hopkins Institute for NanoBiotechnology: http://inbt.jhu.edu

Johns hopkins MedicineDepartment of Neuroscience: http://neuroscience.jhu.edu

Johns hopkins MedicineDepartment of Biophysics and Biophysical Chemistry: http://biophysics.ed.jhmi.edu/ BIOPHYS

Johns hopkins MedicineInstitute for BasicBiomedical Sciences: www.hopkinsmedicine.org/ institute_basic_biomedical_ sciences

the american association for the advancement of Science: www.aaas.org

‘Science’ magazine: www.sciencemag.org

Continued from page 1

AAAS

level. Keratin gene mutations are causative for a large number of dominantly inherited diseases, including epidermolysis bullosa simplex. Following his discovery of muta-tions in select keratin genes of EBS suffer-ers, which he made as a postdoctoral fellow at the University of Chicago, Coulombe has continued to investigate this important problem and devise new ways to approach EBS-related conditions therapeutically. Coulombe’s laboratory also discovered several previously unknown functions for keratin proteins, including a role in regulat-ing protein synthesis and epithelial cell sur-vival and growth during epithelial remodel-ing events. Such nonmechanical functions are contributing to cell and tissue homeosta-sis in circumstances of acute stress as well as chronic disease. As part of the section on biological sci-ences, David Draper, a professor of chemistry in the Krieger School of Arts and Sciences and director of the university’s intercampus Program in Molecular Biophysics, was named for distinguished contributions to the field of biology, particularly for contributions to the understanding of the fundamental principles of RNA folding and protein-RNA binding. RNA molecules were once thought to be primarily passive carriers of genetic informa-tion, but active roles for RNA molecules in the functioning of cells and viruses now are continually being uncovered. These addi-tional roles require some RNAs to adopt intricate structures and recognize other cel-lular components. Draper has used a vari-ety of physical, biochemical and genetic techniques to explore the various strategies RNAs use to fold into their functional struc-tures and to respond to cellular factors. Some of the RNAs that are being studied include structures essential for retrovirus infectiv-ity, a target for an antibiotic that inhibits protein synthesis, and “riboswitches” that modulate gene expression in response to changing cellular conditions. As part of the section on medical sci-ences, Marcelo Jacobs-Lorena, a professor in the Bloomberg School of Public Health’s Malaria Research Institute and W. Harry Feinstone Department of Molecular Micro-biology and Immunology, was elected for distinguished contributions to the field of insect vector biology, particularly malaria parasite/mosquito interactions and genetic modification of mosquito vector compe-tence. His research focuses on the interac-

tions between Plasmodium, the parasite that causes malaria, and mosquitoes that transmit the disease to humans. Malaria kills more than 1 million people every year. Jacobs-Lorena is pioneering a novel approach to make mosquitoes inca-pable of transmitting the malaria parasite. His studies have examined ways to genetically modify the mosquito itself and to change the bacteria that inhabit the mosquito gut. He also has identified the mechanisms used by the malaria parasite to invade and traverse mosquito midgut and salivary glands, a pro-cess that is essential for malaria transmission. Jacobs-Lorena’s laboratory is also exploring the mechanism by which the malaria parasite recognizes and invades the mammalian liver. As part of the section on neuroscience, David J. Linden, a professor of neuroscience in the School of Medicine, was elected for distinguished contributions to the field of cellular neurophysiology; in particular, his fundamental advances to our understanding of the cellular and molecular substrates of memory. Linden researches many aspects of mem-ory, including everything from when memo-ries are first collected to how they affect our ability to interact with the world. His work focuses on the cerebellum, the part of the brain that receives input from our senses and influences motor functions such as walking. Nestled inside the cerebellum are the Purkinje neurons, cells that act as a “sketch pad” for the brain, a space for temporary information storage of one to 100 seconds. These sketches of how our sur-roundings look, sound or feel help influence our interaction with the world, everything from moving around obstacles to using fine motor skills such as writing. Linden researches how Purkinje neurons and other cells in the cerebellum function, utilizing rodent models to learn how the cells store information and how they com-municate with other parts of the brain. By examining a single cell’s reaction to electric stimulus or observing which molecular mes-sages cells send to other cells, Linden has made significant advances in understanding how memory works. As part of the section on engineering, Peter C. Searson, the Joseph R. and Lynn C. Reynolds Professor of Materials Science and Engineering in the Whiting School, was elected for distinguished contributions to the field of surface chemistry and nanosci-ence. His research interests include surface and molecular engineering and semiconduc-tor quantum dots. Searson directs the interdivisional Insti-tute for NanoBioTechnology, which was launched in May 2006 to bring together

Johns Hopkins researchers in the fields of medicine, engineering, the sciences, and public health to create knowledge and develop technologies to revolutionize health care and medicine. INBT has more than 190 affiliated faculty members. Searson has secondary appointments in the Krieger School’s Department of Physics and Astronomy and the School of Medi-cine’s Department of Oncology. As part of the section on engineering, Denis Wirtz, the Theophilus H. Smoot Pro-fessor of Chemical and Biomolecular Engi-neering in the Whiting School, was elected for contributions to cell micromechanics and cell adhesion and for the development and application of particle-tracking methods to probe the micromechanical properties of liv-ing cells in normal conditions and disease states. Wirtz studies the biophysical properties of healthy and diseased cells, including interactions between adjacent cells and the role of cellular architecture on nuclear shape and gene expression. Wirtz directs the newly formed Johns Hopkins Engineering in Oncology Center, a Physical Sciences in Oncology Program center of the National Cancer Institute. EOC brings together Johns Hopkins experts in cancer biology, molecu-lar and cellular biophysics, applied math-ematics, materials science and physics to study and model cellular mobility and the assorted biophysical forces involved in the spread of cancer. Wirtz also serves as co-director of the Institute for NanoBioTechnology and has

a joint appointment in the School of Medi-cine’s Department of Oncology. As part of the section on biological sci-ences, Cynthia Wolberger, an investigator with the Howard Hughes Medical Institute and a professor in the School of Medicine’s Department of Biophysics and Biophysical Chemistry, was elected for distinguished contributions to the field of structural biol-ogy, particularly for studies of transcriptional regulatory proteins. Wolberger studies how proteins do their job in the body. AAAS has specifically noted her excellent work characterizing transcrip-tion regulator proteins, those molecules that control gene expression. Although scientists know which molecular players are involved in certain processes, how they work together is a mystery. Wolberger’s research starts at the beginning of the story: discovering how a protein is structured. To learn what a protein looks like, her lab uses X-ray crystallography, a process in which a protein is exposed to focused X-rays. By mapping the patterns the X-rays make, Wolberger can create a three-dimensional model of the complex twists and turns of a protein to help her understand how a protein will bind to DNA, thus turning gene production on or off. Wolberger’s research has led to a better understanding of the molecular mechanisms behind medical problems such as cancer, aging and diabetes.

Contributing this story were Lisa De Nike, Homewood; Tim Parsons, Bloomberg School of Public Health; and Mary Spiro, Whiting School of Engineering/Institute for NanoBioTechnology.

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Nanoparticles

cystic fibrosis mucus at a much greater veloc-ity than ever before, thereby improving drug delivery. This work is critically important to moving forward with the next generation of small molecule– and gene-based therapies.” Beyond their potential applications for cystic fibrosis patients, the nanoparticles also could be used to help treat disorders such as lung and cervical cancer and inflam-mation of the sinuses, eyes, lungs and gas-trointestinal tract, said Benjamin C. Tang, lead author of the journal article and a postdoctoral fellow in the Department of Chemical and Biomolecular Engineering. “Chemotherapy is typically given to the whole body and has many undesired side effects,” he said. “If drugs are encapsulated in these nanoparticles and inhaled directly into the lungs of lung cancer patients, drugs may reach lung tumors more effectively and improved outcomes may be achieved, espe-cially for patients diagnosed with early stage non–small cell lung cancer.” In the lungs, eyes, gastrointestinal tract and other areas, the human body produces layers of mucus to protect sensitive tissue. But an undesirable side effect is that these mucus barriers can also keep helpful medica-tions away. In proof-of-concept experiments, previous research teams led by Hanes earlier demon-strated that latex particles coated with poly-ethylene glycol could slip past mucus coat-ings. But latex particles are not a practical material for delivering medication to human patients because they are not broken down by the body. In the new study, the research-ers described how they took an important step forward in making new particles that biodegrade into harmless components while delivering their drug payload over time. “The major advance here is that we were able to make biodegradable nanoparticles that can rapidly penetrate thick and sticky mucus secretions, and that these particles can transport a wide range of therapeutic mol-ecules, from small molecules such as chemo-therapeutics and steroids to macromolecules such as proteins and nucleic acids,” Hanes said. “Previously, we could not get these kinds of sustained-release treatments through the body’s sticky mucus layers effectively.” The new biodegradable particles comprise two parts made of molecules routinely used in existing medications. An inner core, composed largely of polysebacic acid, or PSA, traps therapeutic agents inside. A par-ticularly dense outer coating of polyethylene glycol, or PEG, molecules, which are linked to PSA, allows a particle to move through mucus nearly as easily as if it were moving through water and also permits the drug to remain in contact with affected tissues for an extended period of time. In Hanes’ previous studies with mucus-penetrating particles, latex particles could be effectively coated with PEG but could not release drugs or biodegrade. Unlike latex, however, PSA can degrade into naturally

occurring molecules that are broken down and flushed away by the body through the kidney, for example. As the particles break down, the drugs loaded inside are released. This property of PSA enables the sus-tained release of drugs, said Samuel Lai, assistant research professor in the Depart-ment of Chemical and Biomolecular Engi-neering, while designing them for mucus penetration allows them to more readily reach inaccessible tissues. Jie Fu, an assistant research professor, also from the Department of Chemical and Biomolecular Engineering, said, “As it degrades, the PSA comes off along with the

drug over a controlled amount of time that can reach days to weeks.” PEG acts as a shield to protect the par-ticles from interacting with proteins in mucus that would cause them to be cleared before releasing their contents. In a related research report, the group showed that the particles can efficiently encapsulate several chemotherapeutics, and that a single dose of drug-loaded particles was able to limit tumor growth in a mouse model of lung cancer for up to 20 days. Hanes, Zeitlin, Lai and Fu are all affiliated with the Johns Hopkins Institute for Nano-BioTechnology. Other authors on the paper are Ying-Ying Wang, Jung Soo Suk and Ming Yang, doctoral students in the Johns Hop-kins Department of Biomedical Engineering; Michael P. Boyle, an associate professor in Pulmonary and Critical Care Medicine at the Johns Hopkins School of Medicine; and Michelle Dawson, an assistant professor at the Georgia Institute of Technology. This work was supported in part by fund-ing from the National Institutes of Health, a National Center for Research Resources Clinical and Translational Science Award, the Cystic Fibrosis Foundation, the National Science Foundation and a Croucher Foun-dation Fellowship. The technology described in the journal article is protected by patents managed by the Johns Hopkins Technology Transfer Office and is licensed exclusively by Kala Pharmaceuticals. Justin Hanes is a paid con-sultant to Kala Pharmaceuticals, a startup company in which he holds equity, and is a member of its board. The terms of these arrangements are being managed by The Johns Hopkins University in accordance with its conflict-of-interest policies. The PNAS journal article can be viewed at www.pnas.org/content/106/46/19268.full .pdf.

This is a partial listing of jobscurrently available. A complete list

with descriptions can be found on the Web at jobs.jhu.edu.

Job OpportunitiesThe Johns Hopkins University does not discriminate on the basis of gender, marital status, pregnancy, race, color, ethnicity, national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status, or other legally protected characteristic in any student program or activity administered by the university or with regard to admission or employment.

S c h o o l s o f P u b l i c h e a l t h a n d N u r s i n g

h o m e w o o d 41467 Instrument Shop Supervisor41521 Research Technologist41676 Campus Police Officer 41695 Sr. Laboratory Coordinator42088 Development Officer41161 Sr. Technical Support Analyst41453 Academic Adviser41503 Director, Multicultural Affairs41585 Financial Manager41782 Recreational Facilities Supervisor41881 Academic Program Manager41965 Accounting Specialist41980 Sr. Research Assistant42019 Associate Director, Financial Aid42072 Testing and Evaluation Coordinator42129 Financial Aid Administrator41856 Electrical Shop Supervisor41900 Research Technologist41921 Fulfillment Operations Manager42021 Locksmith42103 Sr. Energy Services Engineer

Office of Human Resources: Suite W600, Wyman Bldg., 410-516-8048JoB# PoSItIoN

41384 Assistant Program Manager, CTY41564 Sr. Systems Engineer41584 Executive Assistant41630 Instructional Designer41663 IT Project Manager41749 Law Clerk41790 Development Data Assistant41836 Development Coordinator42035 Information Technology Auditor42037 Internal Auditor41238 LAN Administrator41260 Campus Police Sergeant41340 Campus Police Lieutenant, Investigative Services41343 IT Manager

Office of Human Resources:2021 East Monument St., 410-955-3006JoB# PoSItIoN

41848 Sr. Administrative Coordinator41562 IT Service Coordinator41151 Research Assistant42060 Budget Analyst41989 Budget Specialist41473 Program Specialist41388 Program Officer40586 Project Director, Research 2 Prevention40189 Laboratory Assistant42369 Teaching Assistant41398 Research Data Analyst42309 Payroll Coordinator42043 Research Program Assistant42299 Retention Specialist 40927 E-Learning Coordinator, PEPFAR41380 Strategic Project Coordinator

41197 Sr. Program Officer II/Team Lead42011 Program Specialist40912 Clinic Assistant41561 Sr. Sponsored Project Analyst39308 Software Engineer 42257 Laboratory Helper39306 Programmer Analyst39296 Data Assistant42247 Research and Community Outreach Coordinator41785 Sr. Program Officer41724 Program Coordinator40770 Sharepoint Developer42099 Administrative Coordinator41692 Research Program Assistant 38840 Communications Specialist41877 Health Educator41995 Sr. Medical Record Abstractor41652 Development Coordinator38886 Research Assistant42347 Research Program Coordinator41463 Research and Evaluation Officer40769 Software Engineer39063 Research Assistant41451 Multimedia Systems Specialist

P O S T I N G S

S c h o o l o f M e d i c i n e

Office of Human Resources: 98 N. Broadway, 3rd floor, 410-955-2990JoB# PoSItIoN

38035 Assistant Administrator35677 Sr. Financial Analyst30501 Nurse Midwife22150 Physician Assistant

38064 Administrative Specialist37442 Sr. Administrative Coordinator37260 Sr. Administrative Coordinator38008 Sponsored Project Specialist36886 Program Administrator37890 Sr. Research Program Coordinator

Notices B U L L E T I N B O A R D

the 2010 youthWorks Summer Jobs Program — Teens interested in working in the YouthWorks Summer Jobs Program 2010 can participate in a paid summer internship designed to provide exposure to careers, mentoring and education while developing responsibility and experience. This year 250 high school and college students will have the opportunity to gain work experience and exposure to Johns Hopkins University and the Johns Hopkins Health System through the paid intern-ship. Interns will work from 9 a.m. to 3:30 p.m., Monday through Friday, from June 21 through July 30. They will also participate in mandatory educational sessions. The dead-line for applications is March 5. Applications and more information are available online, beginning Jan. 4, at www

.hopkinsmedicine.org/jhhr/community/youthprograms.html. For more information, contact HR REACH/Community Education Programs at 410-502-3090 or 410-955-1488 or e-mail johnshopkinssummerjobsprogram@ymail .com.

english as a Second Language — Registration is now open for the Krieger School’s English as a Second Language spring program. Evening classes in Oral Communication at the intermediate and advanced levels and in Academic and Pro-fessional Writing at the intermediate level will run from Jan. 25 to April 30 at the Homewood campus. Classes are open to students and profes-sionals within Johns Hopkins and the Balti-more community. For Hopkins employees, tuition remission may apply. For course descriptions and placement information, go to www.ltc.jhu.edu, e-mail [email protected] or call 410-516-5431.

Related Web sitesJustin hanes group: www.jhu.edu/chembe/hanes/index .html

Pamela Zeitlin group: www.hopkinscf.org

Johns hopkins Institute for NanoBiotechnology: http://inbt.jhu.edu

JHU Gazette 4.75 x 3.5

JOB FAIRTO PROMOTE DIVERSITY IN INDEPENDENT SCHOOLS

Saturday, February 20, 20108:30 a.m. to 2:00 p.m.

Gilman School in Baltimore, MDVisit www.aimsmd.org for registration forms

to TEACH in a private, independent schoolRegistrations must be mailed with resumes

No faxes or emails accepted(those postmarked by February 5th will be available for schools to preview)

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ClassifiedsaPartMeNtS/houSeS For reNt

Bayview, 3BR, 2BA house, W/D, CAC, fin’d bsmt, sec dep and refs req’d. 410-905-5511.

Bolton Hill, lg, fully furn’d 1BR apt, avail Jan-Aug, quiet house, access to transportation. $1,075/mo + utils. Mary, 443-622-9986.

Bolton St, charming apt w/2BRs, walk-in closets, marble BA w/whirlpool, living rm, kitchen, W/D, balcony, public transportation, 10.5 ft ceilings. $1,300/mo incl gas, water. [email protected].

Brewers Hill, 3BR, 2.5BA RH, all appls incl’d W/D, plenty of storage, off-street prkng, no smoking/no drugs, pets OK w/deposit, discount for 2-yr lease, great for 3 roommates. 443-921-6238 or [email protected].

Butchers Hill, 2BR, 2.5A TH, steps to medi-cal campus, hdwd flrs, W/D, CAC, rear yd, off-street prkng incl’d. $1,200/mo + utils. 443-838-5575.

Charles Village, 2BR, 2BA corner condo w/balcony, 24-hr front desk, clean, 1,200 sq ft, nr JHMI shuttle, CAC/heat, all utils incl’d. 410-466-1698.

Charles Village/University One, bright, spa-cious 1BR, 1BA condo, CAC/heat; also avail for purchase. $1,200/mo + sec dep. 540-785-8231 or [email protected].

Cross Keys, 2BR, 2BA in gated community, lg living rm, renov’d kitchen, dining rm, W/D in unit, hdwd flrs, freshly painted, tennis courts, pool. $1,200/mo. 443-534-4593.

East Baltimore, 3BR, 1BA TH. $950/mo. Anita, 410-675-5951 or Nancy, 410-679-0347.

Fells Point (Aliceanna at Broadway), 2BR, 2BA apt, top-of-the-line appliances, granite countertops, 2 blks to water, bike to Hopkins. $1,595/mo. 805-338-2277.

Greengate, huge 4BR TH, walking distance to the Quarry, great schools (Summit Park ES). $1,785/mo. 410-925-9773 or 410-484-1607.

Hampden, 3BR, 2BA TH, dw, W/D, fenced yd, nr light rail. $1,100/mo + utils. 410-378-2393.

Harborview, beautiful 1BR + enclosed den condo, 1.5BAs, 2 balconies, spectacular water view. $1,900/mo. 410-727-6898 or 100harbor@ gmail.com.

Homeland, charming 2BR TH in gated com-munity, 3 levels, 2 full and 2 half-BAs, deck, garage. $1,800/mo. 443-622-6049.

Homewood/Guilford, 1BR high-rise condo nr JHU, rent incl doorman/security, pool, prkng. 757-773-7830 or [email protected].

Mt Washington, 2BR, 2BA apt + lg loft, W/D, dw, fp, hdwd flrs, balcony, garage, elevator, serene area. $1,400/mo. 301-525-4505.

Mt Washington, 5BR, 3.5BA house, 2-car garage. $2,300/mo + utils. 443-939-6027 or [email protected].

Mt Washington, sublet 2BR apt in secluded gated community, nr Mt Washington campus, avail Jan-Feb, DSL, fitness center, meditative, open. $750/mo + utils (discount for cat care). 410-764-3494.

Mt Washington, 3BR, 2.5BA duplex, 2,700 sq ft, hdwd flrs, stainless steel appls, fp, jacuzzi tub, W/D, dw, CAC, deck, garage, safe, convenient. $1,950/mo incl utils. 410-367-4441.

M A R K E T P L A C E

Mt Washington, 3BR, 3.5BA TH in nice neighborhood, AC, heat, W/D, wood/crpt flrs, deck, prkng, 10-20 mins to JHU/JHH/Summit Park ES. $1,700/mo + utils. 410-419-1731.

Park City, Utah, ski-in/ski-out at Marriott Moun-tainside, 2 rm unit avail Jan 24-31 ($1,000), 1 rm studio avail Jan 31-Feb 7 ($500). Ginny, 410-458-2878 or [email protected].

Park City, Utah, 1BR deluxe ski-condo, sleeps 4, walk to lift, great snow through March, rent wkly. 410-817-6778.

Patterson Park, 2BR, 1.5BA house, hdwd flrs, crpt upstairs, stainless steel appls, skylight, expos’d brick, 1.25 mi to JHMI. $1,100/mo. 443-286-4883.

Rodgers Forge, 3BR, 2BA TH, W/D, CAC, fin’d bsmt, family-friendly neighborhood, great Balti-more County schools. $1,600/mo. dickgeorge@ comcast.net.

Wyman Park area, spacious, sunny, fully furn’d 1BR apt in safe building, avail Feb 1. $1,000/mo. [email protected].

3BR, 2.5BA waterfront TH, 3 flrs, fully furn’d, gourmet kitchen, stainless steel appls, fp, soak-ing tub, wine cooler, 2-car garage. $3,300/mo. Sonny, 443-955-2040.

Office space, 800 sq ft, visible from street, 2 interior offices, lg central space, storage, bath, kitchenette; extra storage, webcams, wireless avail; nr Hunt Valley, Owings Mills and 795. $700/mo. 443-471-6161.

2BR, 1.5BA apt in registered historic carriage house, nr Gunpowder Falls bike trail, pref fac-ulty/grad students. $1,200/mo. 410-472-4241.

6136 Parkway Drive, 1BR, 1BA apt in tree-lined neighborhood, updated kitchen (new refrigerator, gas stove, microwave, garbage dis-posal), living rm, W/D, storage. $750/mo + utils + sec dep ($750). Joe, 410-746-1126.

houSeS For SaLe

Bolton Hill, very beautiful house, 2 big BRs, 2.5BAs, immaculate, hdwd flrs, new roof and windows. $313,000. 410-383-7055.

Charles Village/Guilford, sunny 1BR condo w/den, 24-hr front desk, 1/2 blk to JHU shuttle, MLS#BA7177675. $139,900. 443-534-8664.

Mt Vernon, 1BR condo in historic bldg, high ceilings, chandeliers, parquet flrs, intercom, 2 ornamental fps w/marble mantels, dw, disposal. $146,900. [email protected].

Timonium (8 Tyburn Ct), updated, spacious 4BR, 3BA single-family house, walk to Dulaney High, 2 mi to I-83 and light rail station. $375,500. Debbie, 410-241-4724.

4BR, 3.5BA house, walk to JHH, buy or rent to buy, owner finance to qualified buyers. [email protected].

rooMMateS WaNteD

Rm on quiet Hampden street, share kitchen, liv-ing rm, yd, porch, W/D, CAC, wireless Internet. $500/mo + deposit. [email protected].

Lg, partly furn’d bsmt BR w/priv BA in renov’d 3BR RH in Mayfield, across from Herring Run Park, nr Lake Montebello, 10 mins to JHMI, perf for visiting medical prof’ls. $600/mo incl utils and wireless. [email protected].

Share Bonnie Ridge apt w/JHU grad students, own BR/BA, furn’d common rms, W/D, CAC, w/w crpt, balcony. $485/mo + 1/3 utils. 443-854-2303.

F JHU prof’l wanted for 1BR in 2BR, 2BA apt in Mt Washington (6318 Greenspring Ave). $432/mo + 1/2 utils. 410-419-1691 or hopkinscgs@ gmail.com.

Share 2BR Fells Point apt, no pets/no smok-ers. $500/mo incl all utils, Internet and W/D. [email protected].

Rm in furn’d Catonsville house, W/D, deck, backyd, nr park, nr I-69/I-95, flexible lease. $625/mo + utils (high-speed Internet incl’d). 410-409-0692 or [email protected].

F wanted for furn’d, spacious (700 sq ft) BR in 3BR Gardenville house, modern kitchen w/granite countertops, landscaped yd, lg deck, sign 1-yr contract and get one month free. $550/mo + utils. [email protected].

Fully furn’d lg BR and priv BA, walk-in closet. $675/mo incl utils and Internet + sec dep ($325). 404-808-7990 or pritteeyez@aol .com.

CarS For SaLe

’01 Toyota Sequoia, 4WD, black w/tan leather, 3 rows of fold-down seats, tinted windows, moonroof, 5-CD player, remote start, 2-yr-old tires, clean, runs great, well maintained, insp’d, 134K mi. $13,500/best offer. 410-526-0415.

’98 Volvo S70, sunroof, leather interior, power everything, new tires, recent tune-up, excel cond, 80K mi. $6,000/best offer. 410-366-8507.

’99 Honda Civic CX, 2-dr hatchback, silver, one owner, 117K mi. $4,000. [email protected].

’98 BMW 740, 99K mi. $8,200/best offer. 410-530-6892.

’97 Toyota Camry LE, well maintained, new tires, 116K mi. $3,700/best offer. [email protected].

IteMS For SaLe

Full-size mattress, Tiffany table lamp (almost new); prices below market, Rockville/DC area. 240-447-3925.

Full-size futon and frame. $15. 443-220-2184 or [email protected].

4G Zune Black, new and unopened. $100. 410-206-2830 or [email protected].

Chicco high chair, “Sahara”-style, folding, reclining, adjustable height, removable tray, safety harness, excel cond. $50/best offer. [email protected].

Vintage chair, made in Sweden in 1960s. $260/best offer. Elizabeth, 443-631-0881 or http://bit.ly/5fg6LE (for pics).

Towson spa eyebrow waxing certificate. Best offer. 410-337-9877 (after 8pm) or i1__hotmail .com.

27" TV, $45 (free iron w/purchase of TV); glass showcase, $35; sofa, $100; twin bed w/mattress, $100; Ikea computer desk, $40. 410-337-5124.

Frying pan, 3 pots (sm, med and lg), spaghetti pot; all pots have lids. $15/set. beansavonmom @hotmail.com.

Vintage Scan entertainment cabinet, 62" x 69", drawers, lower doors, drop-down desk, TV hole 29"W x 22.25"H, heavy, in good cond. $75/best offer. 410-444-1273.

Conn alto saxophone, mint condition. $650/best offer. 410-488-1886.

McClaren infant rocker w/canopy, navy blue, barely used. $20. 410-377-7354.

Pair of exterior French doors, new, white, 8 ft x 3 ft, made of Auralast wood, 15 double E-glass panels, double locks. $750/both. 443-768-4751.

Classified listings are a free ser-vice for current, full-time Hop-kins faculty, staff and students only. Ads should adhere to these general guidelines:

• Oneadperpersonperweek.A new request must be submitted for each issue. • Adsarelimitedto20words, including phone, fax and e-mail.

• WecannotuseJohnsHopkins business phone numbers or e-mail addresses.• Submissionswillbecondensedat the editor’s discretion. • DeadlineisatnoonMonday, one week prior to the edition in which the ad is to be run.• Realestatelistingsmaybeoffered only by a Hopkins-affiliated seller not by Realtors or Agents.

(Boxed ads in this section are paid advertisements.)Classified ads may be faxed to 443-287-9920; e-mailed in the body of a message (no attach-ments) to [email protected]; or mailed to Gazette Classifieds, Suite 540, 901 S. Bond St., Bal-timore, MD 21231. To purchase a boxed display ad, contact the Gazelle Group at 410-343-3362.

PLaCING aDS

www.brooksmanagementcompany.com

Johns Hopkins / Hampden

WYMAN COURT APTS. (BEECH AVE.) Effic from $570, 1 BD Apt. from $675, 2 BD from $775

HICKORY HEIGHTS APTS. (HICKORY AVE.) 2 BD units from $750

Shown by Appointment 410-764-7776

Christian Dior Norwegian blue fox fur coat, medium size, full-length, great holiday gift. $1,200. 443-824-2198.

Dressing table w/shelves, printer, computer, chair, microwave, 3-step ladder, reciprocating saw, tripods, digital piano. 410-455-5858 or [email protected].

Moving sale: TV, sm stereo, breakfast bar stools, dining rm set, 2 chairs, desk, tall and short bookshelves, filing cabinet. 443-824-2198 or [email protected].

Baby equipment: cot w/mattress, trimmings, $25; swing, $10; high chair, $10; carseat, $5; also Gazelle fitness machine, $20; cycle rack, $5; portable AC unit, $20. 410-366-7383.

SerVICeS/IteMS oFFereD or WaNteD

Free to good home: Eastern three-toed box turtle, terrarium, heat lamp, food and all acces-sories incl’d. 410-664-7204.

Prof’l painting, reliable, affordable, qual-ity work interior/exterior, 23 yrs’ experience, licensed, free estimates. 410-570-2364.

College writing teacher available to edit your graduate thesis, proposal, research writing, APA and Chicago formats experience. Eliza-beth, 443-794-2100.

Looking for babysitter on occasional nights and wknds for 1-yr-old in Charles Village, refs req’d. [email protected].

Seeking musicians ASAP for small church in the Cockeysville area. 443-621-4980 or 443-413-1603.

Cardio kickboxing/self-defense classes, Suite 175, 1 Village Square (Cross Keys). 443-625-9744 or www.cftks.webs.com.

Experienced tutor avail for GRE verbal; sched-ule a lesson. 310-409-7692 or [email protected].

Karaoke available for special events, parties, birthdays, children’s parties a specialty; reason-able rates. Angie, 410-340-3488.

Horse boarding/lessons in Bel Air, bring your horse or ride one of our show-quality school horses. $325 (full care) or $250 (partial care). 410-458-1517 or www.baymeadowfarm.net.

Piano tuning and repair, “Craftsman” mem-ber of the Piano Technician’s Guild serving Peabody and Center Stage. 410-382-8363 or [email protected].

Need help with your JHU retirement plan investments portfolio? Free consultations. 410-435-5939 or [email protected].

Friday Night Swing Dance Club, open to public, no partners necessary. 410-583-7337 or www.fridaynightswing.com.

Horse boarding, 20 mins from JHU, beauti-ful trails from farm. $500/mo (stall board) or $250/mo (field board). 410-812-6716 or argye [email protected].

Power washing, no job too small; free estimate. Donnie, 443-683-7049.

Interior/exterior painting, home/deck power washing, general maintenance; licensed, insured, free estimates, affordable. 410-335-1284 or [email protected].

Licensed landscaper available for leaf and snow removal, trash hauling, Taylor Landscaping LLC. 410-812-6090 or romilacapers@comcast .net.

Affordable landscaper/certified horticulturist avail to maintain existing gardens, also plant-ing, designing, masonry; free consultations. 410-683-7373 or [email protected].

Priced to sell! Pet friendly condo, blocks from JHU! Modern/European kitchen w/ceramic tile floors, Zodiac Countertops SS Apps., LR w/original brick FP, formal DR, French doors, sunroom, entry foyer, HWD fls. & molding! New energy effic. windows, & A/C alarm, 1 Pkg. space.

Shana Witman, 443-266-6038, [email protected] Mary Lapides, [email protected]

410-727-0606 EHO

For Sale - $300,000 or Rent - $1600 per mo. Rodgers Forge End-of-Group, 3BR/2BA w/garage! For more info, call or email: Dale Bock, 410-560-5858, 410-218-9813 [email protected] Keller Williams Excellence, EHO


Calendar S e M I N a r S

Mon., Jan. 4, noon. “Regulation of SUMOylation and Control of Chromo-some Segregation,” a Biochemistry and Molecular Biology seminar with Michael Matunis, SPH. W1020 SPH. eB

Mon., Jan. 4, 12:15 p.m. “Canine Morphology: Hunting for Changes and Tracking Mutations,” a Carnegie Insti-tution Embryology seminar with Elaine Ostrander, National Human Genome Research Institute/NIH. Rose Audito-rium, 3520 San Martin Drive. hW

thurs., Jan. 7, noon. Myc Regulation of Cellular Metabolism and Prolifera-tion,” a Cell Biology seminar with Chi Dang, SoM. Suite 2-200, 1830 Bldg. eB

thurs., Jan. 7, 1 p.m. “Plasticity and Processing in the Whisker Map in Rodent Somatosensory Cortex,” a Neu-roscience research seminar with Dan Feldman, University of California, Berkeley. West Lecture Hall (ground floor), WBSB. eB

Fri., Jan. 8, 2 p.m. “Etiology of Viral Gastroenteritis and Rotavirus Vaccine Effectiveness Among Navajo and White Mountain Apache Children,” an Inter-

national Health thesis defense seminar with Lindsay Grant. W2030 SPH. eB

Mon., Jan. 11, noon. “Living With Oxygen: Tales of Superoxide Dismutase,” a Biochemistry and Molecular Biolo-gy seminar with Valeria Culotta, SPH. W1020 SPH. eB

Mon., Jan. 11, 12:15 p.m. “Roles for RB and E2F in the Control of Cell Prolif-eration,” a Carnegie Institution Embryol-ogy seminar with Nicholas Dyson, Har-vard Medical School. Rose Auditorium, 3520 San Martin Drive. hW

J A N . 4 – 1 1 .

(Events are free and open to the public except where indicated.)

aPL Applied Physics LaboratoryBrB Broadway Research BuildingCSeB Computational Science and Engineering BuildingeB East BaltimorehW HomewoodKSaS Krieger School of Arts and SciencesPCtB Preclinical Teaching BuildingSaIS School of Advanced International StudiesSoM School of MedicineSoN School of NursingSPh School of Public HealthWBSB Wood Basic Science BuildingWSe Whiting School of Engineering

CalendarKey


Sonneborn

held up its end of the bargain for nearly 16 years, until the items inexplicably would be placed in storage for decades. For the past 50 years, the collection has been scattered, the bulk of it out on loan to a local syna-gogue. This past November, however, nearly 20 pieces of the Sonneborn Collection returned to Johns Hopkins. This spring, the balance of the collection will follow and Sonneborn’s original vision can be realized. The Sonneborn Collection is being exhib-ited on the third-floor landing of the Smok-ler Center for Jewish Life in the Harry and Jeanette Weinberg Building, the home of Hopkins Hillel, located at 3109 N. Charles St. The permanent exhibition came as a result of collaboration between Hopkins Hillel and three university programs—the Leonard and Helen R. Stulman Program in Jewish Studies, the Program in Museums and Society, and the Cultural Properties Program of the Sheridan Libraries. Jackie O’Regan, curator of cultural prop-erties, said that she learned of the existence of the collection in 2006, when she was curator of Evergreen Museum & Library. When O’Regan assumed her current posi-tion in late 2007, she brought the collection to the attention of Elizabeth Rodini, direc-tor of Museums and Society. “One of my responsibilities is to connect cultural objects with appropriate faculty and programs of study, and also making sure all of our loans are up-to-date,” O’Regan said. “This particular loan was long over-due.” O’Regan and Rodini agreed that some-thing should be done to bring these objects back to Johns Hopkins, especially given the recent creation of a Jewish studies program at the university. The pair approached Ste-ven David, director of Jewish Studies and

vice dean for centers and programs. He, too, agreed that the Sonneborn Collection needed to reunite with Johns Hopkins. First, they had to locate the objects. David said that required some basic detec-tive work. “The collection had been scattered and, in a larger sense, forgotten,” David said. “We had to find out what became of Sonneborn’s donation.” Sonneborn, the owner of Henry Son-neborn & Co., once the largest clothing fac-tory in the world, had originally wanted to create a “handsome museum of art antiques” at Johns Hopkins. The collection was first stored, and likely displayed, at McCoy Hall on the university’s original campus downtown. In addition to housing Sonneborn’s gift of Judaica, McCoy Hall was the home of the university’s archae-ological museum. In 1916, the collection was relocated to the university’s new Homewood cam-pus, just three years before a fire destroyed McCoy Hall. Some records claim the objects also resided in Evergreen House for a short period. Then, for some unknown reason, the objects went into storage. In 1960, the Sonneborn family requested that the collection be loaned out indefi-nitely to the Baltimore Hebrew College (later University), as Johns Hopkins was not using it for its intended purpose. Henry Sonneborn Jr. would later make additional contributions of Judaica to his father’s col-lection. In 1983, the bulk of the objects were transferred to the Sonneborns’ syna-gogue, Temple Oheb Shalom, located near Baltimore Hebrew College, so they could be properly maintained and displayed. The pieces have since graced the lobby of the synagogue and, on occasion, been employed in ritual. Rodini said that Temple Oheb Shalom leaders were immediately agreeable about the prospect of Johns Hopkins reacquiring the collection. “They especially liked the fact that students would be working with the objects,” Rodini said. “They also appreciated the original purpose of this collection.” A student in the Museums and Society Program, Sarah DePaolo, expressed inter-est in the objects and, with fellow student Suzanne Gold, applied for an Arts Innova-tion Grant to curate a handpicked portion of the collection. The two put together the Smokler Center installation, which was dedicated on Nov. 6. The exhibition, called “A Handsome Museum: Selections From the Henry Son-

neborn Collection of Judaica,” features 20 of the finest objects in the collection, including a late-19th-century silver Torah breastplate, a silver and gold kiddush cup, a silver spice box dating back to 1864 in Russia, brass Hanukkah lamps from Eastern Europe and three shofars (rams’ horns). The items, which have been cleaned and polished, are housed in a museum-quality display case donated by the Jewish Studies Program. The current exhibition is focused on the history of the collection and how and why it returned to Johns Hopkins. O’Regan said that the timing had a lot to do with the confluence of factors, specifically the cre-ation of Jewish Studies and her position as curator of cultural properties. “And we had this relatively new Museums and Society Program and the Smokler Center, Hillel’s first permanent home,” she said. The plan is for the Sonneborn Collec-tion to be a rotating exhibit, O’Regan said. Currently, Gold, a senior Writing Seminars major, is working on a second installation, which might focus on the ritualistic use of the objects themed on the five senses.

Gold said that she has relished the oppor-tunity to work with this collection. “As a student curator, I am able to inter-act with the objects in a really unique way, exploring how a collection of such prestige and age can remain relevant and intellectu-ally engaging to students in a modern uni-versity setting,” she said. “The Sonneborn Collection has also become the centerpiece for an open dialogue, providing one of many opportunities in the Jewish community at Hopkins for discussion about Jewish cultural heritage and ceremonial tradition.” Rodini said that she wants to keep the Sonneborn Collection “alive” through new interpretations of the objects by allowing students to present their own points of view through curatorial expression and exhibi-tion. She adds that very little is known about the history of the individual pieces. “We’d like there to be fluidity with the collection and the objects to be installed,” Rodini said. “I would hope that other stu-dents express interest in this conservation effort and [that] we can eventually curate all the objects.” To date, roughly 75 pieces of the origi-nal collection have been located, O’Regan said, the majority of them at Temple Oheb Shalom. The fabric pieces likely did not survive, she said, while other objects might have been lent to individuals or community groups. “We are trying to locate as much as we can,” she said. “While we appreciate its ceremonial use, Mr. Sonneborn didn’t give us the collection for religious purposes. He gave it for study.” Rabbi Debbie Pine, executive director of Hopkins Hillel, said that the collection has become a “great access point” for both Jew-ish and artistic study, and that the exhibit attracts a lot of attention from visitors. “At Hillel, we strive to engage students in multiple ways. Some are drawn to prayer, some to learn about Israel, some to social-ize,” she said. “We see the Sonneborn Col-lection as another avenue in which to get students involved in Jewish life. And it’s also a way for students who might be pre-med or engineering majors to engage in art. It’s a tremendous honor for us to host this incredible and beautiful collection.”

a detail of a breastplate that would adorn a torah. It is one of 20 pieces that have been assembled into the exhibition titled ‘the Sonneborn Collection of Judaica.’

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