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2015 / 2016 ANNUAL REPORT 1

the future of healthyaging 2015/2016 ANNUAL REPORT

aDVanCing innoVationS

in aging anD Brain

health

ContentS

5MessagefromBaycrestPresident&CEO,WilliamReichman,MD

6ReportfromourManagingDirector,RonRiesenbach

9PavingaNewPath

10NetworkPartnerCollaborationsDesignedtoMakeaDifference

12HighlightsfromourFirstYear

14OurPartners

15ProjectsDesignedtoMakeaDifference

22FinancialReport

4 THE CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION

a unique CollaBoration DriVing health

innoVationS for the aging

population


MessagefromBaycrestPresident&CEO,WilliamReichman,MDItiswithimmensepridethatIintroducethefirstAnnualReportoftheCanadianCentreforAgingandBrainHealthInnovation(CC-ABHI),andprovideasnapshotofwhathasbeenanextraordinaryinauguralyear.

CC-ABHIisauniquecollaborationofhealthcare,science,industry,not-for-profit,andgovernmentpartnersstrivingtohelpolderadultsagesafelyinthesettingoftheirchoice.Wearecollaboratingwithcliniciansandindustrypartnerstodevelop,testanddisseminateinnovativesolutionsthatmeettheneedsoftheagingpopulation,inOntario,Canadaandaroundtheglobe.

SpearheadedbyBaycrest,aninternationalleaderincognitiveneuroscienceandcomplexgeriatriccare,theCentrebringstogetheranetworkofpartnerswithestablishedexpertise,resources,andinfrastructure.Thisuniquemodelfacilitatesthetestingandvalidationofinnovationsinreal-worldsettings–innovationsthatincludeemergingmedicaldevices,noveltherapeuticapproaches,newtechnologies,wellnessanddigitalhealthsolutions,nextgenerationhealthcaredeliverypractices,andpractitionerandcaregivertrainingandsupport.

TOgEThER wE ARE AddREssiNg sOmE Of ThE mOsT PREssiNg ANd UNmET AgiNg ANd bRAiN-hEALTh NEEds by:

identifying challenges and opportunities CC-ABHIworkswithinternationalclinicalandscientificexpertstoidentifyhealthsystemneedsandservicedeliverychallengestoguidetheprioritizationofsolutionstoimprovecareoutcomes.

Connecting and engaging stakeholdersCC-ABHIfacilitatesrelationshipsamonginnovators,careproviders,olderadults,andindustrytoimprovethedesign,adoption,andfundingofsolutions.

driving adoptionCC-ABHIworkswithclinicians,olderadultsandotherend-userstoensureuniquesolutionsareadaptedandavailabletotheagingandbrainhealthenvironment.

TheCanadianCentreforAgingandBrainHealthInnovationrepresentsanexceptionalopportunitytodevelopandleadhealthinnovationtoenhanceandextendbrainhealthandcognitivefunction.Throughinnovationandcollaboration,wearehelpingpeopleageintheirsettingofchoicewhilemaintainingcognitive,emotional,andphysicalwell-beingandindependence.

I’dliketothankourstaff,boardmembers,collaborators,governmentfunders,andsupporters.Yourdedicationandpassionhashelpedmakeourfirstyearonetoremember.

wiLLiAm E. REiChmAN, md

PresidentandChiefExecutiveOfficerBaycrest


ReportfromourManagingDirector,RonRiesenbachThefocusofourfirstyearhasbeentointegrateournetworkofcollaboratorsandbuildafoundationforfuturegrowthandsuccess.

Ithasbeenanexcitingfirstyearwithmanyaccomplishmentstospeakofandsharewithyou.Amongmanyimportantmilestonesachievedthisyear,wecompletedacomprehensive5-yearBusinessPlan,developedouryear1,andyear2OperatingPlans,negotiatedandsignedkeyfundingagreements,andlaunchedtheprocessestodevelopfoundationalagreementswithnetworkpartners.Wealsodevelopedkeyperformanceindicatorsandbenchmarksagainstwhichwearemeasuringoursuccess.

Nowintooursecondyear,andwithahighly-skilledmanagementteaminplace,CC-ABHIispoisedtoaccelerateitsactivitiesandrealizeitsgloballeadershipmission.

Fosteringandmaintainingmulti-sectoral,multi-jurisdictionalpartnershipsiscriticalforCC-ABHIinestablishingitselfasanationalhubandgloballeaderinthedevelopment,validation,commercialization,andadoptionofbrainhealthandseniors’caresolutions.CollaborationenablesCC-ABHItoleveragetheuniqueskillsandexpertiseofadiversegroupoforganizationstoadvancepromisinginnovativesolutionsfromprototype,tobedside,tomarket,andthispastyearwehaveengagedwithournetworkpartnerstoplanhowtoleverourcombinedstrategies.Asweenterintoyear2ofoperation,weareexcitedtoformandfacilitatenewcollaborationswithlocal,national,andinternationalpartners.

IthasbeenimmenselyrewardingtoserveasManagingDirectorthroughoutwhathasbeenaveryexcitingfirstyearforCC-ABHI.OnbehalfoftheCC-ABHIteam,Iwanttorecognizeandthankourkeyfunders,theMinistryofResearchandInnovation,PublicHealthAgencyofCanada,andBaycrestFoundationfortheirfundingsupport.Ialsowanttorecognizeandthanktheinnovatorsinvolvedinouryear1launchprojectswhosepassionandcreativityhaveprovideduswithatremendouskick-starttowardsmakingasignificantimpactinagingandbrainhealth.

Ilookforwardtocontinuingourworktogetherandtobuildingonoursuccess.

RON RiEsENbACh

ManagingDirectorCanadianCentreforAgingandBrainHealthInnovation

Vice-President,Innovation&ChiefTechnologyOfficerBaycrest

miSSion

Toacceleratethedevelopment,validation,commercialization,

disseminationandadoptionofinnovativeproducts,services

andbestpracticestosupportbrainhealthandaging.

ViSion

Aworldinwhichpeoplecanageinthesettingoftheirchoice,

maintainingtheircognitive,emotional,andphysicalwell-being,

andindependenceaslongaspossible.

the Centre’S aCtiVitieS are groupeD aS:

Wedothisby:

•Researchinganddevelopingsolutionstomaintainand

enhanceaging;

•Supportingcompaniesandinnovatorsindemonstrating,

testing,andimprovingproductsandprocessesdesignedfor

agingadultsandthementalorcognitivehealthofseniors;

•Disseminatingsolutionsbyprovidingvenuestopromote

adoptionandexpansionondemand.

Develop Disseminatetest



we are reimagining

aging

TheAgingSimulationSuit

paVing a new pathTheCanadianCentreforAgingandBrainHealthInnovation(CC-ABHI)istheresultofthelargestinvestmentinbrainhealthandaginginCanadianhistory–andinconcertwithourpartnersandsupporters,we’rereinventingthewaypeoplegrowolder.

CC-ABHIisasolutionacceleratorfortheagingandbrainhealthsector.Ourfirst-of-its-kindpartnershipofhealthcare,science,industry,andgovernmentexpertsisahubforthedesign,development,andtestingofinnovationshelpingadultsagesafelyinthesettingoftheirchoice,whilemaintainingcognitive,emotional,andphysicalwell-beinglonger.

Theseinnovationsrepresentthemostpromisingsolutionstoaddressoutstandingbrainhealthandseniors’careneeds,includingmedicaldevices,therapeuticapproaches,emergingtechnologies,wellnessanddigitalhealthsolutions,healthcaredeliverypractices,andpractitionerandcaregivertrainingandsupport.

Operatingbywayofacombinationofgovernmentinvestment,charitableandin-kindcontributions,andfee-for-servicerevenuegeneration,theCentrebringstogetheranetworkofmulti-sector,multi-jurisdictionalpartnerswithresources,infrastructure,andexpertiseinagingandbrainhealth.

2015 / 2016 ANNUAL REPORT 9TheAgingSimulationSuit


network partner CollaBorationS DeSigneD to make a DifferenCeOurnetworkpartnershavededicatedresources,infrastructure,andexpertisetoenableCC-ABHItodevelopsolutions,testtheminreal-worldsettings,anddisseminateknowledgeandbestpractices.

NetworkpartnersarecriticalenablersofCC-ABHI’smissionthroughhelpingtoidentifychallengesandopportunitiesintheagingandbrainhealthspace,connectingandengagingstakeholders,anddrivingadoptionofnovelinterventions.CC-ABHIhasengagedwithleadingacademic,publicsector,not-for-profit,andindustrypartnerstosupportitsmissionandobjectives.

Asleadersinthesector,theSeniorsQualityLeapInitiative(SQLI)haschosentopartnerwithCC-ABHItofosteracultureofinnovationinthelong-termcaresector.TheSQLIseekstopositivelychangethecareexperienceandqualityoflifeofolder

adultsinlong-termcaresettingsthroughanoperationalmodelthatadvancesevidence-basedbestpracticesandfacilitateslearningamongorganizations.

Aconsortiumof14ofthehighestperformingeldercareorganizationsandtheirassociateduniversitiesinNorthAmerica,theSQLIprovidesatestinggroundforinnovativeproductsandservices.Membersprovidetheiruniqueexpertisetoenableevaluation,dissemination,andadoptionofnewcarepractices,whiledesigningandbeta-testingemergingtechnologiesthatsupportseniors’well-beinginreal-worldcaresettings.SomeoftheinauguralinnovationsCC-ABHIis

pursuingincludeanonlinecognitiveassessment,consumer-directedcognitiveneuro-rehabilitativestrategies,facialrecognitionsoftware,remotewellnessmonitoring,health-coachingsoftware,mobilemedicationmonitoringandtele-dementiacare.

CC-ABHIhasestablishedaworkinggroupandhasundertakenacapacitycensustoassesstheplayers,resourcesandopportunitiesforeffectiveinnovationandknowledgedissemination.Inthecomingyear,togetherwithSQLIpartners,welookforwardtopursuingseveralinitiativesthatwillserveascatalystsforinnovation.

sQLi mEmbER ORgANizATiONs

Baycrest,Toronto,ON

BruyèreContinuingCare,Ottawa,ON

CapitalCareGroupInc.,Edmonton,AB

DonaldBermanMaimonidesGeriatricCentre,Montreal,QC

EmoryHealthcare–BuddTerraceatWesleyWoodsCenter,Atlanta,GA

HebrewHomeatRiverdale,Riverdale,NY

HebrewSeniorLife,Boston,MA

JewishHomeofSanFrancisco,SanFrancisco,CA

PresbyterianSeniorLiving,Dillsburg,PA

ProvidenceHealthCare,Vancouver,BC

SchlegelVillages,Kitchener,ON

ThePerleyandRideauVeterans’HealthCentre,Ottawa,ON

WestminsterCommunitiesofFlorida,Orlando,FL

YorkCareCentre,Fredericton,NB

sQLi sTRATEgiC ANd ACAdEmiC PARTNERs

AccreditationCanada

CanadianInstituteforHealthInformation

CanadianPatientSafetyInstitute

FloridaStateUniversity

interRAICanada

interRAIUSA


foStering a Culture of innoVation

Dr.JedMeltzer


highlightS from our firSt yearInCanada,peoplearegettingolderandlivinglonger.In20104.8MCanadians(14%)wereseniors,by2036thatnumberisexpectedtogrowto10.4M(25%).

WiththenumberofseniorsinCanadaexpectedtodoubletomorethan10millioninthenexttwodecades,andtoincreasemoredramaticallystillinthetwodecadesthereafter,comesanurgentneedtouncovernewwaystohelpadultsnavigatetheirolderyears.Togetherwithourpartners,wearedeveloping,testing,anddisseminatinginnovationsdesignedtooptimizecareandimprovequalityoflifeforolderadultsandtheirfamilies.

Inadditiontolaunchingmultipleprojectsrepresentinginitialstepstowardspromisinginnovationsinagingandthebrainhealthsectorforolderadults,CC-ABHI’sfirst-yearmilestonesinclude:

NEw PROdUCTs ANd sERviCEs

Severale-learningproductsrelatedtoaging,screeningandmanagingofdementiaanddepression,andrecognizingchangesinclientconditions,havebeendevelopedanddeployedthroughtheMichenerInstitutefortheAppliedHealthSciences,St.MichaelsHospitalandthroughtheMedicalDirectorsofLong-TermCarefacilities.

NEw PRACTiCEs

DesignedforPersonalSupportWorkers,Nurses,AlliedHealthProfessionals,andUnitClerks,thedevelopmentoftheCentreforLearning,Research&Innovation(CLRI)TeamEssentialsforEngagingFamiliesinCaremodulewascreatedtoeducatelong-term-carehealthcareprovidersonhowtodeveloptailoredSituation,Background,AssessmentandRecommendation(SBAR)reportsasaleadingpractice.

shARiNg KNOwLEdgE

Dr.NicoleAndersonpublishedanabstractthatinvestigatedthefeasibilityandefficacyofhavingvolunteersatlong-termcarehomesadministeracognitivestimulationprogramtoresidents.Thisresearchdiscoveredthatthevolunteer-administeredcognitivestimulationprogramdemonstratedbothfeasibilityandefficiency.

PROdUCTs OR sERviCEs EvALUATEd

Aspartofprojectdevelopmentinitiatives,Dr.JenniferRyanandherteamconductedathoroughevaluationoftheeye-trackingcognitiveassessmenttool.TheproductevaluationwasdoneinanefforttofurtherdeveloptheprojectintoausefultoolforclinicianstousetodetectmemoryimpairmentcommontoAlzheimer’sdiseaseandotherdementias.

PRACTiCEs EvALUATEd

UsingCC-ABHIresources,Dr.DeirdreDawsonparticipatedinthedevelopmentofamusictherapyinterventionfortheBrainHealthPromotionproject,aninitiativethatpromotesnon-pharmacologicalinterventionsandprocessestopromoteandoptimizebrainhealthacrossthelifespan.

KNOwLEdgE ExChANgE

HighlightsfrommultipleeventsthroughouttheyearincludetheCC-ABHIInnovationExpo(April2015);GoalManagementTraining“TraintheTrainer”workshopatBaycrest(June,2015);TheCanadianPartnershipforStrokeRecoveryWorkshoponNeuropsychAssessmentforRehabilitation(November2015)insupportofEye-TrackingCognitiveAssessmentTool.

ExhibiTs

CC-ABHIparticipatedintheOntarioTradeMissiontoChinatobuildrelationshipsanddiscoverleadingagingandbrainhealthtechnologytobebroughtintotheCC-ABHIprojectpipeline.Further,participationintheWorldProfessionalOrganizationEvent(WPO)affordedCC-ABHItheopportunitytopresenttoleadingPresidentsandCEOsandinformthemabouttheCC-ABHImission,correspondingprojects,andfuturepartnershipopportunities.

PUbLiCATiONs

Atotalof57peer-reviewedpublicationswerepublishedfromanumberofCC-ABHIprojects.ThesepublicationsdisseminatedinformationtoinformandeducatethehealthcarecommunityontopicsspecificallyalignedtoCC-ABHI’sfocusonaging,brainhealthandinnovation.

Art-on-the-brain

Eye-Tracking Cognitive Assessment Tool

brain health Promotion

innoVation pipeline

12 unique proDuCtS or SerViCeS eValuateD

3 praCtiCeS eValuateD

12 ExhibiTs

2new praCtiCeSDeveloped,refinedorintroduced.

new proDuCtS or SerViCeSDeveloped,refinedorintroducedin-houseorbypartners.7

Conferencesortradeshowdisplays.

57peer-reVieweDpuBliCationS:

manuSCriptS, paperS, BookS

yEAR ONE

Formalworkshops,courselectures,train-the-trainerevents,ortele-educationevents.

41KNOWLEDGEEXCHANGEEVENTS

143SHARINGKNOWLEDGE

EVENTS

Public/communitylecturesororal/posterpresentationssharedatacademicorclinicalconferencesortosocietiesandinterestgroups.

By the numBerS


seed fund

our partnerSFosteringandmaintainingmulti-sectoral,multi-jurisdictionalpartnershipsiscriticaltoCC-ABHI’ssuccess.WorkingwithmultiplepartnersenablesCC-ABHIandBaycresttoleveragetheuniqueskillsandexpertiseofmultipleorganizations.

Ourfoundingpartnersincludeleadingindustry,academic,publicsector,andnot-for-profitorganizations.Eachhascommittedtheessentialresourcesforouractivitiesandinitialsuccess.Collectively,ourpartners,includingfederalandprovincialgovernments,willcontribute$123.5millionthroughoutourfirstfiveyearsforuseindeveloping,testing,anddisseminatinginnovationsdesignedtosupportandultimatelyenhancequalityoflifefortheworld’sagingpopulation.

Ourpartnersinclude:

Network Partners:Partnersbringingdedicatedresources,infrastructure,andexpertisetoenableCC-ABHItodevelopandtestsolutionsinreal-worldsettingsanddisseminateknowledge/bestpractices.

WiththesupportofCC-ABHI,theSQLIpartnersworkwithinterRAItodevelopacomprehensivecomparativereportcardoutliningeachmembers’performanceonanumberofqualityofcaremetrics,trendingtheirperformanceovertimeandincomparisonwitheachother.Thiscontinuallyupdatedreportcardhasenabledfocusedqualityimprovementworkinnumerousareasincludingfallswithinjury,unnecessarytransferstoemergencyrooms,andpainmanagementinlong-termcare.Overtheyearssignificantimprovementshavebeenreportedbythemajorityoforganizations.WorkingwiththeSQLIgroupofseniors’careorganizations,wehaveacomprehensiveplantosupportanaccelerationofthelearningandadoptionofbestpracticestofurtherdrivethequality,accessibilityandthecosteffectivenessofcare.

Project PartnersClients(e.g.,industry,healthcareorganizations,technologydevelopers)withexistingintellectualpropertyorsolutionsthatenterintoagreementswithCC-ABHIandleveragetheCentre’sresources(suchasBaycrestorotherNetworkPartnerresources)todevelopand/ortestnovelsolutions.

funding Partners Government,philanthropic,andotherpartnersthatpledgefinancialsupporttoestablishandsustainCC-ABHI’scoreoperationsandactivities,andmaycontributetotheidentificationofnovelcollaborationsorideasaswellaspartnersandnetworks.

projeCtS DeSigneD

to make a DifferenCe

network partnerS

AgE-wELL

george brown College

OCAd University

Ontario brain institute

maRs discovery district & maRs innovation

saint Elizabeth health Care

sQLi*

University of Toronto

projeCt partnerS

Cogniciti

invivo Communications

Johnson & Johnson

meditext

muse

Ontario Telemedicine Network

QoC health

Quanta Computer

Telus health

The Art gallery of Ontario

funDing partnerS

baycrest foundation

ministry of Research and innovation

Public health Agency of Canada

* See page 11 for full list of SQLI member organizations and SQLI strategic and academic partners



projeCtS DeSigneD

to make a DifferenCe

Weaspiretobecometheworld’spremiernetworkdedicatedtoacceleratingthedevelopment,testing,anddisseminationofsolutionsinagingandbrainhealth.Itisourobjectivetoimprovethewell-beingofseniorsandtheirfamilies,enhancethequalityandeffectivenessofcare,andspurinnovationinCanadaandglobally.


“AccesstotheolderadultpopulationandsettingatBaycrestprovidesuswithreal-lifeinsightontheutility,applicability,andscalabilityofourplatform.Thecollaborationenablesustorefinetheplatformwithpropercontent,applications,anddesignimprovementstowardsasuitablesolutionthatwouldgenerategenuinevalueforolderadultsinCanadaandaroundtheworld.OurpartnershipwithCC-ABHImakesthisimportantworkpossible.”

Terence huang, AssociateDirectoratQuantaComputerInc.

qoCa home Solution trialOvercoming Isolation and Preventing Mental Health Decline in Older Adults

TheQOCAhomesolutionisacloud-basedplatformdesignedtoimprovesocialconnectednesstolessentheeffectsofisolationandloneliness.ThecommercialpartnerforthisprojectisTaiwan-basedQuantaComputerInc.,oneofthelargestcomputermanufacturersintheworld.Theprojectinvolvescustomizing,deploying,andevaluatingtheQOCAhomeplatform,andmorespecificallytheHomeHubtabletdevice,withseniorsandtheircircleofcareintheBaycrestcommunity.2015/16sawthedevelopmentandrefinementoftheQOCAhomeplatformanddevice,advancementsthatwillimproveusability,interface,andcontentforseniorsandtheirfamilies.

online memory anD aging program (map)Scalable Tools to Better Manage Memory

TheMemoryandAgingProgram(MAP)isanevidence-basededucationandinterventionprogramforolderadultsexperiencingnormalage-relatedmemorychanges.Throughinteractivelectures,discussion,andpracticalexercises,participantslearnaboutmemorychangesthatoccurwithage–whatisnormalandwhatisnot–andwhatcanbedonetoimprovememory.Over1,000olderadultshaveparticipatedintheface-to-faceprogramatBaycrest.ThroughCC-ABHI’ssupport,anonlineversionofMAPwillenablesignificantscalability–MAPwillbeextendedtobringbenefitstohundredsofthousandsofolderadults.

triggerUsing Wearable Technology to Overcome Social Isolation and Memory Loss

Memoryretrievalofevents,locationandnamesgetsmoredifficultwithadvancingageandcanbeexacerbatedfollowingastroke,braintumorortheresultofaneurodegenerativedisease.Triggerisaprostheticmemoryapplicationthatenablesindividualswithmemoryimpairmenttore-livethepastincontext,thewaymemoriesshouldbeexperienced.Usingtheapp,memoriescanbetriggeredwithincontextbylocation,time,andfacialrecognitiononamobiledevice.Thesolutionallowsusersofthisapplicationtobrowsememoriesinavarietyofwaysincludingbyperson,placeandtime,andsearchbytextentriesandkeywords.2015/16accomplishmentsincludedtherefinementofthemobileapplicationinordertoimprovethefacialrecognitionaspectofthesolution.


the Virtual BrainForging New Solutions in Personal Brain Healthcare

Deliveringeffectivetherapiesforbraininjuryorcognitivedeclinerequiresastructuralandfunctionalunderstandingofthepatient’sbrain,andtodaythatunderstandingiscomingintofocusthroughaground-breakinginitiativecalledTheVirtualBrain(TVB).TVBisthefirstcomputerizedmodeltocapturetheintricatedetailsofthestructureandfunctionofthebrainundernormalcircumstances;asaresultoftraumaordisease,andasitages.Currently,TVBisusedasaresearchtooltobuildmodelsthatpredictthedevelopmentandprogressofdisease.Withthegoalofexpandingitsclinicaluse,CC-ABHIispartneringwithInteraXonusingitsMUSEheadbandasatypeofmobileelectroencephalogram(EEG)thatcouldenablenewclinicaluses.

“OurpartnershipwithCC-ABHIhasenabledustoaccelerateourpaceofinnovationandisenablingustouseleadingtechnologyinnewwaystopositivelybenefitouragingpopulation.”

derek Luke, DirectorofEngineeringatMUSE

TheVirtualBrain:Dr.RandyMcIntoshandTanyaBrown


eye-traCking CognitiVe aSSeSSmentDetecting Cognitive Decline by Making Eye Contact

Thewayoureyesmovecanrevealtheinformationthatwehaveinourmemories,andwecanexploiteyemovementstoinvestigatechangesinmemoryrelatedtoaging.WithCC-ABHIsupport,Baycrestresearchersaredevelopinganinnovativeeye-trackingbasedassessmenttoolforearlydetectionofcognitivedecline.

Thisprojectinvolvesadaptinglab-basedeye-trackingtasksofcognitionforusewithamobileplatformandobtainingeye-trackingdatafrombothhealthyadults,andthosewithcognitivedecline.In2015/16theprojectteamdevelopedandtestedacognitiveassessmentexamthatistobeusedwitheye-trackertechnologytoscreenformemoryimpairmentscommontoAlzheimer’sdiseaseandotherdementias.

Virtual CareExtending Care Beyond the Hospital

VirtualCareisaninnovativeprojectthatintendstobringhealthservicestotheclient,ratherthanbringingtheclienttotheclinician.Theprojecthasthreesub-projects:ResponsiveBehavioursVideoCapture,BedsideTelemedicine,andPreventionofFallswithInjury.TheVirtualCareprojectisaimedatprovidingthefollowingbenefits:behaviouralsupportforpatientsandcaregiverslivingwithdementiaduringtransitionsbetweencaresettings,sectors,andteams;enhancedaccesstointegratedandspecializedcareteamsforresidentsoflong-termcarehomesandcommunitydwellingclientsthroughtelemedicine,andreducedincidenceofinjuriousfallsandavoidableemergencydepartmenttransfersforresidentsandpatientswithdementialivinginlong-termcareandin-patientrehabunits.

2015/16wasayearforplanningandlayingthefoundationsforworkthatwillbeginintheSpringof2016.In2015/16theteamestablishedprojectcharters,beganthedatainfrastructureupgradesrequiredtosupporttheroll-outoftheprojects,executedkeyenvironmentalscans,andbeganthedevelopmentoftheevaluationframeworksneededtoproperlytestandevaluatetheefficacyoftheseprojects.

neuroVaSCular reaCtiVityUsing MRI Imaging to Improve Early Detection of Dementia

VasculardiseaseinthebrainhasbeenimplicatedinthedevelopmentofvasculardementiaandAlzheimer’sdisease,thetwoleadingformsofdementia.Theabilitytomapcerebrovascularreactivity,akeyindicatorofvascularhealthinthebrain,couldleadtoimprovedwaystodetectthediseaseinitsearlystagesaswellastonewtreatmenttargetstoalleviatediseasesymptoms.TheCerebrovascularReactivityprojectinvolvesdevelopingnovel,non-invasivemethodsusingMRItechnologytomeasurevascularfunctioninthebrainasthekeysupportingmechanismforbrainactivity.In2015/16thedevelopmentandrefinementofanewcerebrovascularreactivitymethodforMRItomeasurebloodflowinthebrainmarkedtheongoingprogressforthisexcitingCC-ABHIfundedproject.Thedevelopedsequencecouldresultinasignificantreductioninscanningtimes,whichinturnmayimpactoverallhealthcarecostsacrossthesector.

“It’stremendouslyexcitingtoknowthatindevelopinganonlineversionofourprogram,we’llbemakingitaccessibletoasignificantlyhighernumberofolderadults.”

Angie Troyer, Phd, CPsych,DirectorofNeuropsychologyandCognitiveHealthatBaycrest

NeurovascularReactivity


mri neuro-informatiCSFinding New Ways to Use Big Data

Intheireffortstounderstanddementiaandotherbraindisorders,scientistshaverecognizedthepromiseofbigdata–verylargesetsofinformationthatmaybeanalyzedtorevealpatterns,trends,andassociationsrelatedtobrainstructure,brainfunction,andhumanbehaviour.However,thestandardsforgatheringandanalyzingdatamayvaryacrossinstitutions,limitingthegatheringandoptimalextractionofinformationforresearchandclinicaltrials.

TheaimoftheMRINeuroinformaticsprojectistodevelopstandardizedarchitecturetoshareneuroimagingdata,essentialhealthinformation,andanalysistoolsnationally.Thiswillcreaterobust,reproducibleMRIdataprocessingandanalysispipelinesthatcanbeusedinpartnercentres.

Dr.StephenStrotherledtheeffortin2015/16todevelopapre-processingsoftwarepipelinetoanalyzebrainimagingdata.Further,Dr.BradBuchsbaumhelpedcreate2machine–learningalgorithmsandsoftwaretoolsfortheclassificationandpredictionofbrainconditionsfrombrainimagingdata.Bycombininglargedatasetsinastandardizedway,thisprojectcanleadtowiderspreaddataanalysesandoffermorestatisticallyinformedoutcomes.

rational neuro-rehaBilitationAccelerating the Timeframe from Questions to Answers in Brain Health

Thediscoveryofnewtreatmentsforbraindisorderssuchasstroke,traumaticbraininjury,dementia,andlate-lifedepressionoftentakesatrial-and-errorapproach.Newtreatmentsareoftentestedwithlittleconsiderationofthespecificunderlyingbrainchangesinadiseaseandoftheimpactofapotentialnewtreatmentontherelevantbrainstructureandfunctionmechanisms.

SupportedbyCC-ABHI,researchersatBaycrestareusingstate-of-thearttechnologyincludingmagneticresonanceimaging(MRI)andmagnetoencephalography(MEG)tounderstanddisease-relatedandacutetreatment-relatedchangesinbrainstructureandfunctioninindividualswithvariousbraindisorders.Additionally,informationisbeinggatheredaboutphysicalandphysiologicalhealthinordertoconstructaholisticpictureofwhatpromoteshealthybrainaging.Thecontinuedadvancementofthisprojectwillallowresearcherstogatherinformationinsmallernumbersofindividuals,acceleratingthetimeframefromquestiontoanswer;researcherswillalsobeableuseanapproachthatinvolvesacomprehensivesetofbrain-imagingandphysical-healthassessmentstoevaluateexistingbraininterventionsandunderstandwhycertaininterventionsworkforsomepatientsbutnotothers.Theworkaccomplishedin2015/16ishelpingtopavethewaytostrongerclinicaltrialsthatsavetimebyfocusingontreatmentsthatappropriatelyimpacttherelevantstructures,processes,andfunctionsofthebrain.

CommuniCationS neuroSCienCeUnderstanding how the Brain Hears

Researchisincreasinglyshowingthatcommunicationdifficultiesarerelatednotonlytotheearbutalsotothebrain,givingrisetothefrequentcomplaint,“Icanhearyou,butIcan’tunderstandyou.”SupportedbyCC-ABHI,Baycrestresearchersareworkingtoincreasetheirunderstandingofhearing,speechperception,andspeechproduction,sotheycanapplythisknowledgetonewandbettertreatmentsandimprovecommunication.Byincreasingourunderstandingofthebrainregionsresponsibleforprocessinglanguageandsounds,thisresearchcontributestonewknowledgethatcanbeappliedtodevelopingnewandimprovedbraininterventionstohelppeoplewithcommunicationimpairmentsenjoybetterconnectionswithothers,leadingtoabetteroverallqualityoflife.

In2015/16Dr.BernhardRosscontinuedthedevelopmentandtestingofanewanalysismethodthatallowsfordigitizationoftheheadin3D,whichcanbeusedinthecontextofanalysingneuroimagingdataacquiredforexamininghearingandlanguageproblemsinseniors.Aswell,Dr.ReginaJokelmaintainedmomentumindevelopingsoftwarethataimstoanalysespontaneousspeechthatwilldifferentiateanddiagnosedisorderslikedepressionordementia.

CommunicationsNeuroscience:Dr.ClaudeAlainRationalNeurorehabilitation:Dr.JedMeltzer


art-on- the-BrainUsing Art to Improve Cognitive and Social Engagement

Olderadults,especiallythosewithcomplexhealthissues,havereducedaccesstorecreationalactivitiesthatprovidecognitiveandsocialengagement,thiscanresultinfeelingsofisolationandloneliness.Art-on-the-Brainusesartworkasavehicleformeaningfulintellectualandsocialengagementforadultswithandwithoutdementia.Theprimarygoaloftheapplicationistopromoteimprovedhealthandwell-being,whilethesecondarygoalistoprovidephysiciansandcareproviderswithaprovenandsafetoolforpatientuse.ThecommercialpartnersforthisprojectareArtGalleryofOntario,CanadianArtMagazine,Memory&Company,QoCHealth,MaRSInnovation,andQuantaComputerInc.

InJune2015themobileapplicationbetaprototypewasdevelopedataHackingHealtheventinToronto,leadingtoArt-on-the-BrainwinningtheGevityInnovationAward,aswellasbeingawardedtherunner-upprizeasOntarioTelemedicineNetwork(OTN)MostInnovativeSolution.Followingthisevent,andthroughout2015/16,theprojectteammetwithpartnercandidatessuchassoftwaredevelopers,designers,andmobileexpertswhohavetheabilitytodevelopthebetaversionofthissolutionintoafullyfunctioningmobileapplicationthathasthepotentialforwidespreadcommercialdissemination.

CogniCiti Brain health aSSeSSmentBrain Health Powered by Science

Earlyidentificationofpotentialcognitiveproblemscouldleadtoearlydiagnosisalongwithappropriatecaredesignedtohelptheindividualmaintaintheircognitivehealthandindependenceforaslongaspossible.CognicitiBrainHealthAssessmentisascience-basedbrainhealthtestdevelopedbyclinicalneuropsychologistsandcognitivescientistsatBaycresttohelpdetermineifcertainmemorychangeswarrantavisittothedoctor.Thetest,foradults50to79,wasco-developedbyCognicitiInc.,whichisownedbyBaycrestandpartnerMaRSDiscoveryDistrict.Todate,morethan40,000adultshavecompletedthetest.ThecommercialpartnerforthisprojectisJohnsonandJohnsonInc.

In2015/16thebetaBrainHealthRegistrywasdevelopedandallowsconsumerswhocompletethebrainhealthassessmenttosignupforfurtherresearchopportunities;thisregistrymaybemadeavailableinthefutureforpharmaceuticalcompaniesandotherResearchandDevelopment(R&D)organizationstorecruitvolunteersforclinicaltrialsandacceleratetheR&Dprocess.Aswell,theinitialdevelopmentstagesofatabletversionofthesoftwaretobroadentheaccessibilityoftheprogrambeganin2016.

online goal management trainingRehabilitating Executive Function Impeded by Brain Disorders

Whenanindividual’sexecutivefunctionisimpairedtheirabilitytocontrolbehaviourdecreases,thiscanaffecttheirabilitytodoeverydayactivitiessuchaswork,remembersimpletasks,orkeepemotionsstable.

GoalManagementTraining®(GMT)isaBaycresttherapywithprovenefficacyintherehabilitationofclientswithexecutivedysfunctionresultingfrombraindisorders.GMTisstructuredintoninemodules,withinteractivediscussionsdesignedtoraiseawarenessofvariousaspectsofgoalmanagement,tasksthatillustrategoalmanagementconceptsinaction,andhomeworkassignmentsdesignedtofacilitatethetransferofconceptstoreallife.

In2015/16theprojectbegandevelopinganonlineversion,whichwillprovidewideraccessforGMTtherapiststoreachmorepatientssuchasthosewhohavelimitedornoaccesstoin-persontherapyduetogeographicalorphysicalrestrictions.


e-learning SyStemDisseminating Information to Educate the Healthcare Community

Forallhealthcareprofessionals,continuouseducationisanimportantpartofensuringconsistentknowledgeandqualitypatientcare.ThisprojectinvolvesdevelopingandimplementingarigorousandcomprehensiveLearningManagementSystemthatprovidese-learningcoursesforhealthcareprofessionalsandthosewhointeractwiththehealthcaresystem,includingseniors,theirfamilies,andtheircaregivers.Thisinitiativewillseetheacquisition,configuration,integrationanddeploymentofCC-ABHI’sLearningManagementSystem.

In2015/16thisprojectdeveloped3modulestoeducatecliniciansonhowtobettercarefortheirpatients,modulesthatwilleventuallypopulatethee-Learningplatform.Onlinemodulesweredesignedaspartofablendedlearningcoursetotrainstaffonhowtoworkwitholderadultsandseniors.Trainingforstaffwasalsoincludedtohelpthemunderstandmoreaboutthecomplexneedsofolderadults,includingnormalagingandsensoryandcognitivechangesthatcanaffectcare.Staffcompletedtheon-linemodulesindependentlyandthenparticipatedinafulldayface-to-faceworkshoptoapplywhattheyhadlearnedonline.Thefirstdeploymentoftheon-linematerialwasfor15cliniciansatSt.Michael’sHospitalinToronto.

Brain health promotionResearching the Impact of Healthy Habits on a Healthy Brain

Arecentstudysuggestedthata10-25percentreductioninriskfactorssuchasdiabetes,mid-lifehypertension,mid-lifeobesity,smoking,depression,andphysicalinactivitycouldpotentiallypreventasmanyas1to3millioncasesofAlzheimer’sDiseaseworldwide.Acomprehensiveunderstandingofhowlifestylefactorscontributetobraindisordersanddevelopingnewinterventionsthatwouldpromotesustainedhealthylifestylebehavioursthroughoutthelifespancouldultimatelyreducetheincidenceofdementiaandotherage-relateddisorders.

SupportedbyCC-ABHI,researchersatBaycrestareinvestigatingfactorsthataffectbrainhealth,includingdiet,socialengagement,andmood,todevelopnon-pharmacologicalinterventionsandprocesses(e.g.lifestylechanges)topromoteandoptimizebrainhealthacrossthelifespan.

Thegoaloftheprojectistoreducethelikelihoodofdevelopingbraindisorderssuchascognitiveimpairment,dementia,andlate-lifedepression.Thisknowledgewillserveasabasisfordevelopingnewinterventionsthattakeintoaccounttheindividual’spsychosocialenvironment,activities,andotherstrategiestopromotesustainedchangesinlifestylebehaviours.

2015/16accomplishmentsincluderesearchperformedbyDr.NicoleAndersonthatexploredthefeasibilityandefficacyofusinglong-termcarehomes’volunteerstoadministeracognitivestimulationprogramtoresidents.Thisresearchdiscoveredthatthevolunteer-administeredcognitivestimulationprogramdemonstratedbothfeasibilityandefficiency.Withadditionalresearch,andlargersamplesizes,thelong-termimpactmayleadtoanefficientandscalablewaytoimprovecognitioninseniorslivinginlong-termcarehomes.

Formorecomprehensiveinformationabouteachproject,includingthechallengeseachisdesignedtocounter,thesolutioneachrepresents,theimpacteachwillhave,andinformationaboutthevalue(KeyPerformanceIndicators)foreach,[email protected]


finanCial reportTOTAL OPERATiONs

CoreOperations $$4,883,000

IndustryProjects $458,692

StrategicProjects $3,081,284

KnowledgeMobilizationProjects $279,008

Total $8,701,984

CORE OPERATiONs

ProjectSupport,BusinessDevelopment&Operations $3,487,929

Develop $361,291

Test&Validate $391,639

Disseminate&Adopt $642,140

Total $4,883,000

iNdUsTRy PARTNER PROJECTs

QOCAHomeSolutionTrial $27,440

ArtontheBrain $124,442

OnlineMemoryandAgingProgram(MAP) $129,393

CognicitiBrainHealthAssessment $177,417

Total $458,692

sTRATEgiC PROJECTs

TheVirtualBrain $506,044

VirtualCare:Dementia&TransitionalCare $659,811

Trigger $29,294

VirtualCare:VirtualRounds $190,287

VirtualCare:CareinTransition $57,004

NeurovascularReactivity $478,482

MRINeuroinformatics $150,735

RationalNeurorehabilitation $213,135

CommunicationsNeuroscience $235,372

BrainHealthPromotion $353,073

Eye-TrackingCognitiveAssessment $208,047

Total $3,081,284

KNOwLEdgE mObiLizATiON PROJECTs

OnlineGoalManagementTraining $248,359

E-LearningSystem $30,650

Total $279,008

The views expressed herein do not necessarily represent the views of the Public Health Agency of Canada.

The Ontario Network of Entrepreneurs (ONE) is funded by the Government of Ontario. For more information visit ONEbusiness.ca. The views expressed herein are the view of The Canadian Centre for Aging and Brain Health Innovation and do not necessarily reflect those of the Government of Ontario.

Baycrestfoundation

THE CANADIAN CENTRE FOR

AGING AND BRAIN HEALTH INNOVATION

3560BathurstStreet

Toronto,ONM6A2E1

T:416-785-2500

[email protected]

ccabhi.com

@ccabhi_

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