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![Page 1: The funding of viral hepatitis: the big question - who.int · 4 | Targets of the Global Health Sector Strategy on Hepatitis Intervention targets Indicator 2030 2020 Baseline 1. HBV](https://reader030.fdocuments.in/reader030/viewer/2022041203/5d4ede4888c9935e578ba6e0/html5/thumbnails/1.jpg)
Chairs:
The funding of viral hepatitis:
the big question
Prof Huma Qureshi Gottfried HirnschallDirector HIV/AIDS Department and Global
Hepatitis Programme
WHO
National Programme Manager
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Stefan Wiktor
The funding of viral hepatitis:
the big question
Team Lead, Global Hepatitis Programme
World Health Organization
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Cost to implement the
global hepatitis strategy –
preliminary results
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4 |
Targets of the Global Health Sector Strategy on HepatitisTargets of the Global Health Sector Strategy on Hepatitis
Intervention targets
Indicator 2030 2020 Baseline
1. HBV vaccination Childhood vaccine coverage 90% 90% 81%
2. HBV MTCT (mother
to child)
Birth dose vaccine coverage
(or other approach to prevent MTC)
90% 50% 38%
3. Safe injection Safe infections (needs to cover in and out facility) 90% 50% coverage 5%
4. Harm reduction Number of needles/PWID/year
(as part of effective harm reduction package)
300
(75% coverage)
200
(50% coverage)
20
5. HBV Treatment Treatment eligible persons with chronic HBV treated 80% 8 million treated
(Est. 5m HBV, 3m HCV)
<1%
6. HCV Treatment Treatment eligible persons with chronic HCV treated 80% <1%
Impact targets
Indicator 2030 2020 Baseline 2015
Incidence New infections of chronic
Hepatitis B and C
90% reduction 30% Approximately 6-10 million infections reduced to less than
1 million by 2030
Mortality Hepatitis B and C deaths 65% reduction 10% 1.4 million deaths reduced to less than 500,000 by 2030
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Factors affecting costing of
hepatitis strategy
• Global distribution of burden of disease
• Health-systems vs. hepatitis-specific costs
• Rapidly changing pricing landscape
• High cost of current care
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Countries with greatest number of persons with viraemic HCV infection
0
1
2
3
4
5
6
7
8
9
10
China Pakistan Nigeria Egypt India Russia U.S. Brazil D.R.Congo
Japan
No
. pe
rso
ns
wit
h v
irae
mic
HC
V
infe
ctio
n (
mill
ion
s)Low income
Lower-middle income
Upper-middle income
High income
Adapted from Gower E et al. J Hepatol (2014)
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7
Countries with greatest number of persons with
chronic HBV infection
Countries with greatest number of persons with
chronic HBV infection
0
10
20
30
40
50
60
70
80
No
. p
ers
on
s w
ith
ch
ron
ic H
BV
in
fecti
on
in
millio
ns
Low income
Lower-middle income
Upper-middle income
High income
Adapted from: Schweitzer et al. Lancet 2015
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Who pays for the interventions:
Health-system vs. hepatitis-programme
Intervention Health-system
cost
Hepatitis
cost
Injection safety
Blood safety
Harm reduction
HBV immunization
HBV treatment
HCV treatment
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Rapidly changing price of drugs
$1
$10
$100
$1,000
$10,000
$100,000
Price of 12-weeks of sofosbuvir
$84,000 US price
$900 “Egypt” price generic price
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• Global distribution of burden of disease
• Health-systems vs. hepatitis-specific costs
• Rapidly changing pricing landscape
• High cost of current care:
– End-stage liver disease
– Substandard or ineffective treatments
• Annual expenditure per patient in China
– Chronic hepatitis US$ 1,600
– Hepatic cancer US$ 6,615
Factors affecting costing of hepatitis strategy
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China: shift to more effective public health approach is cost saving compared to current hepatitis care spending
HCV: 4-5 times returnHBV: 1.3 times returns
Source: WHO China
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Summary of key parameters
Hepatitis B Hepatitis C General
Infant vaccination:
10US$
Birth dose: 100US$
Treatment:
80US$/year
Harm reduction: taken
from UNAIDS costing
Treatment cost per course
Low income: 200US$
Middle income:
500US$
High income
10,000US$
• Blood and injection safety:
limited data, assumes
US$1 million/year/country,
to be updated
Drug-price reduction phased
in by 2020
1%/year efficiencies over
period 2020-30
Non-direct delivery costs at
14% of treatment costs
No discounting over time
Low and MIC income costs
scenario
Self-funding assumed for high
income countries
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Relative cost of hepatitis strategy by
country-income level
15%
15%
28%
41%
Low income
Lower middle
Upper middle
High income
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Cost of hepatitis-strategy interventions
2016-2030 by country income-category
$-
$2
$4
$6
$8
$10
$12
US
$ b
illi
on
co
sts
Low and Middle
Low and LMIC
Low income
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Relative cost of different interventions
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UNAIDS 2015
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Key programmatic questions: how can
elimination be made affordable ?• Reductions in treatment costs
• Move towards more effective public health spending: i.e. reducing ineffective treatment and care costs, estimated as high in middle and higher income countries
• Shared costs with other strategies– Harm reduction costs, contribution of hepatitis programs
– Immunization and blood safety
– Co-infection with HIV and service delivery
• Innovations and efficiencies over time– Simplified treatment package, non specialist care, hepatitis B cure
(not included)
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Spirit of the elimination agenda
– not business as usual
The question is not whether hepatitis elimination is
affordable
But rather
How can we make it affordable?
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Acknowledgments
• Tim Hallet and Shevanthi Nayagam,
Imperial College, London
• Daniel Low-Beer, WHO-HIV Department
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Daniel Lavanchy
The funding of viral hepatitis:
the big question
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Lessons learned Roundtable London, June 2015
Innovative sources for funding of viral hepatitis prevention and treatment in LMIC countries
MeetingHosted by
Presented by Daniel Lavanchy
Pierre Van Damme
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Objectives of the meeting
• To identify ways to increase political commitment and financial sustainability of viral hepatitis prevention and control programmes in countries (incl LMIC)
• To identify potential funders and explore new funding mechanisms
• To discuss lessons learnt about funding other disease programmes
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Objectives of the meeting
• To investigate how to convince and motivate decision-makers to fund viral hepatitis programmes in LMICs
• To provide options for improving access to affordable screening and treatment of viral hepatitis in LMICs
• To list the commitments required for funding by donors, including governments, bilateral and multilateral organizations, non-traditional donors, development banks, foundations, and commercial financial institutions
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London meeting 8-9 June 2015
• Participants represented a cross-section of potential and actual stakeholders from intergovernmental organizations and pharmaceutical company representatives to academics, non-governmental organizations and policy and communications experts.
– WHA
– Viral hepatitis specialists
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Innovative and potential new funding mechanisms
• Need to understand current funding mechanisms and initiatives to better define new funding mechanisms and learn the do’s and don’ts from previous initiatives
• Some current (or potential) funding mechanisms and initiatives have been extremely successful, and several examples were described at the meeting:
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Meeting conclusions on new funding mechanism
• Use existing funds in a different way
• Create side funds to existing bodies engaged in other areas
• Create a specific funding body for viral hepatitis (cfr. Global fund)
• Finding new financing mechanisms
• Lower price of DAAs was also discussed – Volume and tiered pricing
– Voluntary licensing
– Compulsory licensing
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Lower price of DAAs
• Volume and tiered pricing– Example: Vaccine tenders (GAVI, PAHO’s Revolving Fund)
adv: high volume – low price
disadv: time consuming
multiple contracts (applies not only to voluntary licensing)
• Voluntary licensing– Manufacturing generics
Adv: low price
disadv: Multiple contracts
Amount of discounted price is not public domain
Copayment of patient is still ?
• Compulsory licensing– Some governments or NGO try to lower the price by fighting patents(TRIPS)
Disadv:
• Middle- and high-income countries with strict legal frameworks may not benefit;
• It gives a wrong signal to the pharmaceutical industry by lowering the incentives to pursue the research for new drugs and vaccines;
• Solidarity between high income and low income countries disappear (Vaccine)
• The rapid development of new DAAs renders the procedures of signing multiple contracts or fighting through courts time-consuming and prone to rapid obsolescence.
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Potential new funding mechanism
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Use existing funds in a different way
• Examples:– the Global Fund’s Board of the GAVI Alliance;
– UNITAID; and
– the Global Fund for AIDS, Tuberculosis and Malaria
– ...
• This involves reallocating resources and agreeing on new priorities, often through negotiations and without harming existing or pledged services.
• These existing funders should be convinced of the importance of hepatitis funding to adapt their financing strategies.
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Create side funds to existing bodies engaged in other areas
• Examples
– Global and regional funds for resource limited setting (e.g. PAHO’s revolving Fund)
– Initiatives for the prevention and control of disease (e.g. AIDS, Malaria, Poliomyelitis, rare diseases …)
• These bodies have developed an extended experience in building up and managing the complex tasks of tackling a global, regional or national public health problem. They have also gained over times significant expertise in funding and oversight of large and complex public health programs
• Bring “hepatitis” into these experiences would gain time and profit from their lessons learnt
• But most are already heavily burdened by their current activities stuck to their current set priorities and commitments
• To convince them and capture their interest it is essential to search of additional resources
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Create a specific funding body for viral hepatitis
• Create specific mega funds for viral hepatitis
– e.g. dementia Fund created British government
– Global fund for hepatitis, Médecins sans Frontières’ Access Campaign, the Clinton Health Access Initiative, International Decision Support Initiative ..
• creation of many platforms targeting small and/or remote communities is another complementary approach.
– Disadv: • finding the appropriate and efficient managerial structure that ensures adequate distribution of funds, sustainability
• time-consuming process
– Adv:• funds would be dedicated only to viral hepatitis,
(no competing hindrances)
• Lessons can be learned from past experience of HIV/AIDS
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Finding new financing mechanisms
• Examples of possible funding mechanisms (not all used for health issues yet)
– Discounting for large-scale payers
– Crowd-funding
– Micro-financing
– Social impact investments through private equity funding, hybrid philanthropy, venture capital models;
– Social bonds, cat bonds, mortgages, auto loans, micro loans;
– Dedicated local, national or international taxes on specific commodities or activities;
– Creation of a national health insurance system or of insurance companies (private and/or public);
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The way forward
• Pre-requisite for Identification of mechanisms and potential donors
– The development of a fund-raising concept based on a national strategy and action plan.
– Need for data, health economic studies, business case (ROI arguments)
– The fund-raising concept should clearly specify the funds needed to ensure the readiness and functioning of health systems, health care providers and patients
– potential donors, are often not familiar with the field of health care in general and HCV DAA treatments in particular, need to capture their interest(scientific institutions, insurance companies, foundations, or any private or public parties potentially interested in funding HCV treatments)
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The way forward/1
• In summary, recommended actions highlighted during the meeting include:
– Better definition of the burden of disease and socio-economic costs, together with analysis of data and trends; improved quality of data
– Formulation of policies and strategies for prevention and control of viral hepatitis at national level where none exist
– Generation of commitment and political will through continued advocacy, and identification of strong leadership
– Definition of objectives and priority setting
– Identification of a broad base of potential partners in an alliance or coalition to advance and coordinate activities on prevention and control of viral hepatitis at an international level
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The way forward/2
– Identification and establishment of a base for the work described.
– Creation of new partnerships and commitments, with building a business case based on priorities and partners’ interests
– Research into identifying the success factors of projects, programmes and financing mechanisms
– Identification of best practices and demonstration projects for further development
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Panel discussion
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Panellist:
Dr Ganchimeg GomosurenSecretary of State, Ministry of Health & Sports, Mongolia
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Panellist:
Dr Marcelo NaveiraNational Manager for Hepatitis, Brazil
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Panellist:
Dr Jacinto AmanduaCommissioner of Clinical Services for the Ministry of Health, Uganda
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Panellist:
Dr Sagit PriohutomoDirector of Communicable Diseases for the Ministry of Health, Indonesia
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Panellist:
Dr Karen TimmermannsTechnical Officer, UNITAID
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Panellist:
Colleen ConnellSenior Director, Access Programme, Clinton Health Access Initiative