The first Russian-Chinese Agricultural Forum «The status and prospects of the Russian-Chinese cooperation in agriculture»

1 July 2014.

Solagift – the world manufacturer of high technology products from the conifer green

foliage - an export resource of Tomsk Region.

The Solagift story

2003 – construction of the production facility for conifer needles extraction in Semiluzhki,Tomsk Region.

2004 – installation and bringing the carbon dioxide extraction line to production capacities. Launching of СО2 – extracts of ТМ «SibEX ®» on the Russian market.

2006 – Cooperation agreement between «Solagran» Ltd and «SIBEX» Ltd.

2007- 85% shares of «Sibex» belong to «Solagran» Ltd. Start of upgrading plan implementation.

2008 – start-up of the world’s first commercial production of polyprenols (20 March). Making and defence of the business-plan for construction of the GMP-certified factory in the Special Economic Zone in Tomsk.

2010 – launching of Ropren® on the pharmaceutical market of Russia (February). Structural reorganization of the Russian companies into the holding company Solagran Son with 100% capital transfer to Solagran Ltd (May). Purchase of the production facility in Vyshny Volochyok, Tver Region (September).

2011 – a project participant of Skolkovo Innovation Center

2012 – registration of the trademarks in Asia Pacific, Middle East and European Economic Community.

2013 – 10 million rubles budget subsidy for creation of Innovation Center in the Special Economic Zone in Tomsk.

2014 - The winner of the All-Russian contest «Regions – sustainable development»

CORPORATE STRUCTURE (Russia)

Management company «Solagran Son» LLC, Tomsk

Management company «Solagran Son» LLC, Tomsk

Production complexesProduction complexes Scientific groupScientific group Exclusive distributorExclusive distributor

Biotech LLCProduction of

CGNC and provitamin

complex

Vyshny Volochyok,

Tver Region.

Biotech LLCProduction of

CGNC and provitamin

complex

Vyshny Volochyok,

Tver Region.

SIBЕХ LLCProduction of

polyprenol concentrates and

СО-2-extracts,Tomsk

SIBЕХ LLCProduction of

polyprenol concentrates and

СО-2-extracts,Tomsk

Solagift LLCManufacture of finished dosage

forms and pharmaceutical

substances, Tomsk, SEZ

Solagift LLCManufacture of finished dosage

forms and pharmaceutical

substances, Tomsk, SEZ

Darius LLCSkolkovo

Solana BiotechSt. Petersburg

Darius LLCSkolkovo

Solana BiotechSt. Petersburg

Biofar LLC

Tomsk

Biofar LLC

Tomsk

Company’s technologies

The carbon dioxide extraction workshop.

Original patented technology, which enables to extract biologically active substances from the plant by using liquid carbon dioxide supercritical fluid extraction processes. No organic solvents and high temperatures used in the process. No chemical disruption of biologically active substances. The workshop of organic extraction and preparatory chromatography. The technology enables the suite of compounds of conifer green foliage to retain their biological activity and function. The first world’s production of polyprenols under the technology of multistage selective extraction and preparatory chromatography.

Substances – core family of BIOEFFECTIVES

Bioeffective® A

stage II processing

Bioeffective® R

Bioeffective® S

Bioeffective® B

Stage I processing

Bioeffective® N

Bioeffective® V

Bioeffective® P

Coniferous wax

Natural green needles

aqueous extract

Liquid CO2- extraction

Green conifer needles

Essential oils

Bioeffective® I

Bioeffective® E

The company manufactures 11 basic substances - Bioeffectives. The process enables the live elements of conifer needles to be extracted without disruption of their biologically active properties.

Polyprenols - Bioeffective R

Polyprenols are naturally occurring precursors of dolicholsWhich are found in all key organs and soft tissues ofhuman body. Dolichols are essential in protecting cellular membranes, stabilizing cell proteins and supporting thebody’s immune system. They also act as coenzymes inThe synthesis of polysaccharides and in protein – carbohydrate metabolism.

Polyprenols are present in trees and plants, whereasdolichols are found in animals. Ingested polyprenols aremetabolized by the liver into dolichols which then areinvolved in the dolichol-phosphate cycle.

Live conifer needles are one of the richest and mostwidely available sources for polyprenol extraction in the world.

Bioeffective R is a 95-98% concentrate of polyprenols. The compound consists of a series of homologues each containing 13-18 isoprene units (65-90 carbon units) in the molecular chain.

Tissue Concentration, μg/g

spleen 85-165

liver 465-1226

kidney 240-760

lungs 80-100

ovary 1493-3226

heart 240-270

cerebrum 430-680

hypophysis 1400-6058

bowels 230-320

adrenal gland 1270

thyroid gland 1145

pancreatic gland 943

Prostate gland 268

Concentrations of dolichols in various human tissues, μg/g

Pharmaceutical properties of polyprenols

Hepatoprotective – lower cytolysis and cholestasis

markers, fibrosis index

Hypolipidemic – lowering cholesterol, triglycerides, atherogenic factor

Neuroprotective and nootropic - Improvement of memory and attention, regression of the symptoms of polyneuropathy

Antioxidant – increased activity of antioxidant

enzymes. Immunomodulatory – prolonged interferon inducing

action Antidepressant - reduction of depressive symtoms, fast and pronounced spectrum of antidepressant activity against various depressive disorders

Burn and wound healing - reduces healing time of wounds and burns, stimulates the process of complete epithelialization at early stages.

Oncoprotective - ability to inhibit carcinogenesis and initiate the induction of apoptosis of cancer cells.

Gemoprotective - Prevents the pathological changes in the cellular composition of the bone marrow, provides

gemosupressive effects of chemotherapy Adrenotropic - reduces inflammatory process, improves the functional condition of the prostate gland, increases testosterone levels.

Geroprotective – prevents the development of Alzheimer’s and Parkinson’s diseases

Anti-ischemic - significantly reduces the incidence of myocardial infarction, improves coronary blood flow. Protects the brain from metabolic asidosis, prevents the development of energy disturbances.

The pharmacological activity of polyprenols is based on their substitutive effect in the case of dolichol deficits, or deficiencies in the dolichol-phosphate cycle, which are observed with chronic inflammatory, degenerative and oncological diseases.

Pharmaceutical properties of polyprenols

in vivo

Neuro - immuno - hormone regulation

Immunesystem

Endocrinesystem

Liver Brain

R

Ropren ( BIOEFFECTIVE R) – the first Russian innovative pharmaceutical of a new type.

Positioning: Modern tissue protector and stimulator of reparative regeneration. Advantages: shows a wide range of biological properties and hepatoprotective effect in treatment of patients with chronic disorder of the hepatobiliary system. It has a short dosage schedule and convenient form of release; it is obtained from natural raw material ; it has a complex action and restores the essential biochemical processes in liver, pancreatic gland and nervous tissue.

Estimated reserves and polyprenols content in tree species within the forestry of Tomsk Region.

(Report of the TPU Research Institute under the Government contract № 373 of 21 November 2013 )

Health improving and prophylactic mission of Solagift Ltd. in new products (TM BIOEFFETIVE and TAIGA)

Bioeffectives with cell sap of fir

5 kinds

Bioeffectives with cell sap of fir

5 kinds Phytococktails 6 kinds Phytococktails 6 kinds

Bioeffectives based on oil fraction of silver fir extract 5 kinds

Bioeffectives based on oil fraction of silver fir extract 5 kinds

Bio active additive «TAIGA» 3 kinds

Bio active additive «TAIGA» 3 kinds

Creams «Taiga healer» 3 kinds

Creams «Taiga healer» 3 kinds

Biologically active additives based on polyprenols and conifer extracts 6 kinds

Biologically active additives based on polyprenols and conifer extracts 6 kinds

Application of substances from conifer green Application of substances from conifer green foliage in agriculturefoliage in agriculture

«Growth promotants» are biological growth promotant for plants enhancing germination and accumulation of dry biomass of crops.

«Growth promotants» are biological growth promotant for plants enhancing germination and accumulation of dry biomass of crops.

Use of «Growth promotants for plants”» in agriculture provides: active germination of seeds of vegetable and grain crops stimulation of growth for cereal crops ( wheat, rye) pea, onion, cucumber, carrot, cabbage, and increase of crop yieldIncreases resistance to diseases (fungicidal and bactericidal properties) economical consumption - 3 - 10 g/ha

Use of «Growth promotants for plants”» in agriculture provides: active germination of seeds of vegetable and grain crops stimulation of growth for cereal crops ( wheat, rye) pea, onion, cucumber, carrot, cabbage, and increase of crop yieldIncreases resistance to diseases (fungicidal and bactericidal properties) economical consumption - 3 - 10 g/ha

«Feed additives» are natural biological growth promotant of animals and is recommended for use in pig breeding, poultry farming and cattle raising.

«Feed additives» are natural biological growth promotant of animals and is recommended for use in pig breeding, poultry farming and cattle raising.

Use of «Growth promotant» in agriculture : boosts the body weight gain of broiler chickens by 7,7%. Increases safety of animals up to 100% (mortality in the control group was 12,5%) Improves zootechny performance due to lower feed consumption per a kilogram of obtained meat. is an alternative to the use of antibiotics in the treatment and prevention activities

Use of «Growth promotant» in agriculture : boosts the body weight gain of broiler chickens by 7,7%. Increases safety of animals up to 100% (mortality in the control group was 12,5%) Improves zootechny performance due to lower feed consumption per a kilogram of obtained meat. is an alternative to the use of antibiotics in the treatment and prevention activities

The site of the Special Economic Zone in Tomsk – development prospects of highly competitive biotechnological products.

Future production of

substances in SEZ in Tomsk

General view of administrative and production complex

«SOLAGIFT»

The site of the Special Economic Zone in Tomsk – development prospects of highly competitive biotechnology products

Production of substances:

Production of liquid dosage forms and biologically active additives:

Production of solid and soft dosage forms:

Name Yearly capacity, kgProvitamin concentrate (PVC) 37 313

Plant waxes 5 500silbiol 17 670

polyprenols 2 750Chlorophyll carotene paste 1000

Balsamic paste 1000

Sodium chlorophyllin 600

Name Годовая мощность, тыс. флаконов

СО2-extract of Siberian silver fir, oil fraction 2000

СО2-extract of Siberian silver fir, water fraction 440

Ropren 1500

Name Годовая мощностьTablets, including coated tablets 7,9 million units

capsules 23 million units

ointment 142,86 thousand tubes

suppository 2,32 million units

Pharmcluster of Tomsk Region – a tool for company potential commercialization.

Project: «Growth of integrated structure for the development of innovative

medicines based on natural and synthetic raw materials» .

Time: 2014 - 2018.

Project goal: To ensure conditions for continuous production, development and

commercialization of new medical products and technologies starting from

fundamental research to commercial manufacture of products and their further

launch on the Russian and global markets.

OLEOPREN GEPAOLEOPREN CARDIOOLEOPREN NEURO