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Delays disease progressionThe time to radiographic progression doubled in men treated with Abiraterone and Prednisone versus Prednisone alone at 16.5 versus 8.3 months.

Improves survivalOverall Survival (OS) improved by 5 months in the Abiraterone arm.

Extends time with minimal or no symptoms69% of patients had at least a 50% decline in PSA levels with Abiraterone.

ZYTIX Plus Prednisone show improvements in asymptomatic or mildly symptomatic chemotherapy-naive patients with metastatic castration-resistant Prostate Cancer

The First and Only Selective Androgen Biosynthesis Inhibitor

Abiraterone Acetate 250 mg tablet

sttime inBangladesh

L i g h t f o r l i f e


Provides longer survival time

Ensures patient convenience

Manages patient in superior manner

Offers better tolerability

The First Choice for Antiandrogen therapy

icalBicalutamide USP 50 mg Tablet

albumin

Paclitaxel


Advantages of Nab-Paclitaxel over conventional Paclitaxel

elpacNab-Nab-Paclitaxel 100 mg Injection

Targeting the Heart of the Tumor

Increased intratumor Paclitaxel concentrations (33% higher)

53% higher volume of distribution compared to Paclitaxel injection

Shorter infusion time is needed (30 min vs 3 hours)

Maximum tolerated dose is 300 mg/m2 (70% higher dose administration is feasible than conventional Paclitaxel)

Premedications are not required NanoTechnology

Deliv

erin

g

Innovative Therapies

NanoTechnology

Deliv

erin

g

Innovative Therapies

as single therapy, or in combination in

Breast Cancer

Ovarian Cancer

Lung Cancer

Gastric Cancer

Head & Neck Cancer

The first Taxane Approved by FDA for the Adjuvant Treatment of Node Positive Breast Cancer in combination with Standard therapy

The first-line therapy for the treatment of Advanced Ovarian Cancer

The first-line treatment option for advanced or metastatic Non Small Cell Lung Cancer (NSCLC)

elpacPaclitaxel 30 mg, 100 mg & 300 mg Injection

elpac

elpac

The trusted Paclitaxel brand in Bangladesh

Family

L i g h t f o r l i f eRef: Sparano JA, Zhao F, Martino S et al. S3-03. Presented at: San Antonio

Breast Cancer Symposium 2014. Dec. 9-13, 2014; San Antonio, TX.


nastrol

Anastrozole 1 mg Tablet

nastrolThe therapy of choice for postmenopausal breast cancer

Well tolerated in longterm use

Safe & effective as initial adjuvant therapy for hormone-sensitive postmenopausal early breast cancer

Confirmed event-free and relapse-free survival in early breast cancer patients switching from tamoxifen

Considered as standard first-line treatment for hormonallysensitive postmenopausal advanced breast cancer

Once daily dosing

The breast cancer is curableif it is diagnosed on right time !


Sister

Mother

Wife

Aunt

Teac

her

Daug

hter

Cous

in

Survi

vor

I will

beat

this

Love

Life

Reme

mber

your

mamm

ogra

m

Take

care

ofyo

urself

I will

not g

iveup

hope

I beli

eve

inm

iracle

s

Never

surre

nder

Supp

ort

Stre

ngth

Heal

ing

Carin

g

Pray

Amen

Mot

ivate

Insp

ire

Cry

Laug

h

Sing

More effective drug compared to other Aromataseinhibitors concerning

Total aromatase inhibitionSuppressing breast cancer tissue and plasma estrogen levelsSuperior overall response rate Superior tolerability and patient preferenceNo Rheumatologic symptoms (Arthralgia or Myalgia) unlike Anastrozole

Guards against breast cancer relapse for up to 8 years

LexelLetrozole USP 2.5 mg Tablet


Most effective platinum therapy in combination with other approved chemotherapeutic agents

Cisplatin 10 & 50 mg Injection

Metastatic Testicular Tumors

Metastatic Ovarian Tumors

Advanced Bladder Cancer

Non Small Cell Lung Carcinoma

is indicated in

10


as single therapy, or in combination in

Ovarian cancerCervical CancerBrain TumorSolid TumorAs Bone Marrow Transplant Preparative Regimen

Carboplatin 450 mg & 150 mg Inj.

Beat Ovarian Cancer Effectively

Dosage Guidelines

Single-Agent Therapy :360 mg/m2 by intravenous injection on day 1 every 4 weeks.Combination therapy (with cyclophosphamide):Carboplatin 300 mg/m2 by intravenous injection on day 1 everyfour weeks for six cycles.

200 mg/m2 IV on day 1.The cycle is repeated every 21 days.

300-600 mg/m2 once every 4 weeks.

175 mg/m2 once weekly for 4 weeks with a 2 week recoverybetween courses.

500 mg/m2/day for 3 days.

Ovarian cancer

Cervical Cancer

Solid Tumor

Brain Tumor

As Bone Marrow TransplantPreparative Regimen

Squamous Cell Carcinoma of the Head and Neck (SCCHN)

K-Ras Mutation-Negative, EGFR-Expressing Colorectal Cancer

Focus on target

Cetuximab 100 mg Injection

sttime inBangladesh


Approved Indications & Dosage

Indication

Metastatic Colorectal Cancer, with IV 5-FU based chemotherapy (for first- or second-line treatment)

Non-squamous Non-Small Cell Lung Cancer (as first line treatment of unresectable, locally advanced, recurrent or metastatic)

Glioblastoma (as second line treatment)

Metastatic Renal Cell Carcinoma (mRCC)

Cervical Cancer

Ovarian Cancer

Dosage

5 mg/kg IV every 2 weeks with bolus-IFL

10 mg/kg IV every 2 weeks with FOLFOX4

5 mg/kg IV every 2 weeks or 7.5 mg/kg IV every 3 weeks with Fluoropyrimidine-Irinotecan or Fluoropyrimidine-Oxaliplatin based chemotherapy after progression on a first-line Bevastim containing regimen

15 mg/kg IV every 3 weeks with Carboplatin / Paclitaxel

7.5 mg/kg IV every 3 weeks with Cisplatin Gemcitabine

10 mg/kg IV every 2 weeks as single agent with progressive disease following prior therapy

10 mg/kg IV every 2 weeks with interferonalfa

15 mg/kg every 3 weeks with Paclitaxel and Cisplatin or Paclitaxel and Topotecan

10 mg/kg every 2 weeks or 15 mg/kg every 3 weeks

Date of Approval

2004

January 23, 2013

October 11, 2006

-

May 5, 2009

July 31, 2009

August 14, 2014

Nov 14, 2014

Reference

Study AVF 2107

Study 3200

Phase III ML18147 study

Trial E4599

Asia Pac J Clin Oncol. 2011 Sep;7(3):321

Trials AVF3708g& NCI 06-C-0064E

Trial BO17705

Trial GOG-0240

Phase III TrialAURELIA

Bevacizumab 100 mg & 400 mg Injection

Unique Antiangiogenic Drug



Epirubicin Hydrochloride BP 10 mg & 50 mg InjectionErubin

More Effective and Safer Anthracycline therapy

The API of Erubin has been collected from European source and the product quality is confirmed by edQm.

COS* grade of API : More Pure, More Safe

Quality of Medicines & HealthCareEuropean Directorate for the

Increases relapse free & overall survival compared with standard therapiesShorter treatment course with fewer side effectsMore effective and better tolerated than Doxorubicin

A SaferAnthracycline Therapy


Game Changer inBreast Cancer

1st time manufactured in Bangladesh

XevirolThe Golden Key to Overcome Hormonal Resistance

Everolimus INN 5 mg tablet

Everolimus has been Approved for Breast Cancer by

BUR

EAU

OF FOOD ANDDR

UG

S

DEPARTMENT OF HEALTH

REPUBLIC OF THE PHILIPPIN

ES

BFAD

Swiss

Agen

cy for Therapeutic Products

swissmedic

Advanced Hormone Receptor (HR)-positive, HER2-negative Breast Cancer

Advanced Renal Cell Carcinoma

Advanced Pancreatic Neuroendocrine Tumor (pNET)

US

Usual Dose:10 mg once daily

For Hepatic Impairment patient:

5 mg once daily

For Superior Response:Now considered as 1st Line in CML

1st

Lin

e


Indication:

Newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase.

Chronic, accelerated, or myeloid or lymphoid blast phase Ph+ CML with resistance or intolerance to prior therapy including Imatinib.

Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) with resistance or intolerance to prior therapy.

Dasatinib 100 mg tabletDasanix

A new miracle to takeover CML

sttime inBangladesh

Start withConvenientOnce-Daily

Dosing

pill00 mgtime per day


The Victory in cancer without collateral damage

USFDAapproved

1st line

treatment

in CML

Imatinib 100 mg & 400 mg Tablet

Tailor - made to attack cancer cells

Philadelphia chromosome positiveChronic Myeloid Leukemia (CML)

CML myeloid blast crisis

CML accelerated phase

CML in chronic phase prior/afterInterferon-α therapy

Unresectable and/or metastatic malignant gastrointestinal stromal tumours (GIST)


The Foundation of Induction Regimen

Daunorubicin 20 mg InjectionRubicin

Acute myeloid leukemia

Acute lymphocytic leukemia

Neuroblastoma

Rhabdomyosarcoma


An effective drug against a wide range of tumors

Acute lymphoblastic and myeloblastic leukemia

Soft tissue and bone sarcomas

Ovarian carcinoma

Breast cancer

Thyroid carcinoma

Gastric carcinoma

Primary prostatic lymphoma

Hodgkin's disease

Doxorubicin Hydrochloride 10 mg & 50 mgLyophilized Powder for Injection

Ref: J Clin Oncol 32:3824-3830.2014by American Society of Clinical Oncology

Erlotinib 100 mg & 150 mg Tablet

The oral power to fight against NSCLC

As monotherapy in

Treatment of locally advanced or metastatic non-small cell lung cancer

First-line, Second/Third-line treatment of locally advanced or metastatic non-small cell lung cancer

Maintenance treatment of locally advanced or metastatic non-small cell lung cancer

As combination with Gemcitabine (Gemoxen) in

Treatment of locally advanced or metastatic pancreatic cancer


Inhibits EGFR signal but continues life

time inBangladesh

On the 26 June 2009, The European Commission granted marketing authorisation for Gefitinib for the treatment of adults with locally advanced or metastatic NSCLC with activating mutations of EGFR-TK across all lines of therapy.

National Institute for Health and Clinical Excellence (NICE) recommends Gefitinib as an option for the first-line treatment of locally advanced or metastatic non-small-cell lung cancer patients with EGFR mutation positive.

European Medicines Agency

NHSNational Institute forHealth and Clinical Excellence



Highly effective as

Frist line therapy in wild type NSCLC

Second line treatment in EGFR mutated NSCLC

Also effective in combination therapy for the treatment of

Metastatic Prostate Cancer

Advanced Gastric Adenocarcinoma

Advanced Squamous cell Carcinoma

of the Head & Neck

Advanced or Metastatic Breast Cancer

Docetaxel 20 mg & 80 mg Injection

The affordable & dependable docetaxel brand


Extending the Trust

First-line treatment of metastatic breast cancer after failure of prior anthracycline-containing adjuvant chemotherapy.

First-line treatment for inoperable, locally advanced (Stage IIIA or IIIB), or metastatic (Stage IV) non-small cell lung cancer.

First-line treatment for locally advanced (nonresectable Stage II or Stage III) or metastatic (Stage IV) adenocarcinoma of the pancreas.

Treatment of relapsed advanced ovarian cancer in combination with Carboplatin.

Oxaliplatin 50 mg &100 mg Injection

The right weapon to fight against colorectal cancer

Metastatic colorectal cancer

Stage III (Dukes' C) colon cancer after complete resection of primary tumor

as single therapy, or in combination with Fluorouracil / Folinic Acid

or with in


As monotherapy for the treatment of metastatic breast cancer resistant to both paclitaxel and an anthracycline-containingchemotherapy regimen or resistant to paclitaxel.

As first-line treatment of patients with metastatic colorectal carcinoma.

As a single agent for adjuvant treatment in patients with Dukes' C colon cancer.

In combination with docetaxel- for the treatment of metastatic breast cancer after failure of prior anthracycline-containingchemotherapy.

Capecitabine USP 500 mg Tablet

A Unique Oral Option to Boost Survival from Deadly Cancer

Standard

Conf

orm

to International



First-line therapy in DLBCL & follicular NHL

Single maintenance therapy after first-line induction in low-grade/follicular NHL

Monotherapy in relapsed/refractory NHL

First-line & Second-line therapy in CLL

Rheumatoid Arthritis who have had an inadequate response to one or more TNF antagonist therapies

The new treatment paradigm for NHL & CLL

Rituximab 100 mg & 500 mg Injection

timemanufactured inBangladesh


The first & only targeted HER2 therapy proven to increase the chance of living longer both Breast & Gastric Cancer

Recommended for 1 year adjuvant treatment option for early-stage HER2-positive breast cancer

First line treatment of HER2 overexpressing metastatic breast cancer

Also indicated for the treatment of HER2+ metastatic gastric or GEJ cancer who has not received prior treatment for metastatic disease.

TrastunixTrastuzumab 440 mg Injection

A Revolutionary Treatment Option for HER2+ cancers

real breakthrough for

HER2+ cancers


The Only Approved Systemic Therapy for HCC

Sorafenib 200 mg Tablet

Established Efficacy and Safety in Advanced Hepatocellular carcinoma patients treated > 1 year

The majority of AEs were Grade 1 or 2 and occurred early in therapy

No unexpected or cumulative toxicities occurred with long-term treatment


FDA Approved first line therapy for mRCC patients

Once daily

Sunitinib 50 mg Capsule

Prolonging survival, reducing toxicity

NCCN Category 1 recommendation as a 1st line treatment for clear-cell mRCC since 2008.

Established in the treatment of advanced RCC with more than 6 years' experience since FDA approval.

Most prescribed among oral medications approved for the treatment of advanced mRCC in the world.


Refractory Anaplastic Astrocytoma

Newly diagnosed Glioblastoma multiforme

Refractory Glioblastoma multiforme

Temozolomide 100 mg & 250 mg Capsule

The One & Only Standard Treatment Option for GBMs


Tamoxifen 10 mg & 20 mg Tablet

Tam leThe gold standard drug for estrogen receptor-positive breast cancer

Tam leGold standard treatment for estrogen receptor-positive breast cancer for morethan 30 years

WHO listed essential drug for the treatment of breast cancer

First chemopreventive agent approved by FDA for the reduction of the risk of breast cancer

Inexpensive treatment option for estrogen receptor-positive breast cancer

Extended Duration forGreater Protection


CytabinCytarabine 100 mg Injection

A Potent Antimetabolite to Cure AML

timemanufactured inBangladesh

Cytarabine is indicated alone or in combination for induction of remission and/or maintenance in patients with

Acute myeloid leukemiaAcute non-lymphoblastic leukemiaAcute lymphoblastic leukemiaAcute lymphocytic leukemiaBlast crisis of chronic myeloid leukemiaDiffuse histiocytic lymphomas (non-Hodgkin's lymphomas of high malignancy)Meningeal leukemiaMeningeal neoplasms

Dosage and Administration:IV/SC: The recommended dose is 100 mg/m2/day (days 1 to 7) or 100 mg/m2 IV every 12 hours (days 1 to 7).


Vincristine Sulfate 2 mg Injection

Nature's anticancer power

Acute lymphocytic leukemia

Hodgkin's disease

Non-Hodgkin's malignant lymphomas

Rhabdomyosarcoma

Neuroblastoma


Secure & Reliable Partner

Ifosfamide USP 1 gm & 2 gm Injection

First-line Therapy:

Xifos with anthracyclines is a valid option for symptomatic, locally advanced or inoperable Soft Tissue Sarcomas (STS)

First-line treatment for patients with intermediate or poor-risk Germ Cell Tumors (GCT)

Salvage Therapy:

Conventional-dose Xifos, if patients did not receive it previously.

High-dose Xifos, for those who already received conventional Xifos.

0 Hour 4 Hours 8 Hours Ifosfamide 1.2 gm/m2 - - Mesna 240 mg/m2 240 mg/m2 240 mg/m2

Dose & Administation of Xifos & IfomesMesna is given as intravenous bolus injections in a dosage equal to 20% of the Ifosfamide dosage (%w/w) at the time of Ifosfamide administration and 4 and 8 hours after each dose of Ifosfamide. The total daily dose of Mesna is 60% of the Ifosfamide dose. The recommended dosing schedule is indicated as-


Lenalidomide INN 10 mg & 25 mg capsule

Fights against hematological malignancy

Multiple Myeloma (MM)

Mantle Cell Lymphoma (MCL)

Myelodysplastic Syndrome (MDS)


Superior antitumor activity of Irinotecan-based regimen over

best supportive care

As first-line for metastatic Colorectal Cancer (mCRC)As second-line single agent for CRC that has recurred or progressed following Fluorouracil based therapy

Other Uses:

Non Small Cell Lung Cancer2

Recurrent Glioblastoma3

Advanced Ovarian Cancer4

A New Survival Standard for mCRC

Irinotecan Hydrochloride USP 40 mg & 100 mg Injection


Folinic Acid (Leucovorine) BP 50 mg Injection

50The real choice for synergistic and chemo protective effect

Enhances the anticancer effect of 5-Flurouracil

Rescue therapy during high-dose ofMethotrexate chemotherapy

Provides better therapeutic efficacyin Stomach and Colon cancer

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