The Electrolitolysis ( ELLYS ) FROM THE BASIC RESEARCH TO THE FORMULATION OF A NEW THERAPEUTIC...
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Transcript of The Electrolitolysis ( ELLYS ) FROM THE BASIC RESEARCH TO THE FORMULATION OF A NEW THERAPEUTIC...
The Electrolitolysis ( ELLYS )
The Electrolitolysis ( ELLYS )
FROM THE BASIC RESEARCH TO THE FORMULATION OF A NEW
THERAPEUTIC METHOD
Ernesto FinaDipartimento Nefro-Urologico A.O.R.N. Cardarelli Napoli
76° Congresso Nazionale SIU - Corso CLU
ELECTROLYTIC DISSOLUTION OF URINARY STONES
O
ELECTROLITOLYSISO
ELLYS
ELECTROLYTIC DISSOLUTION OF URINARY STONES
O
ELECTROLITOLYSISO
ELLYS
Direct anodic oxidation
Oxidation by born oxigen
Protolysis
Takes place by creating an electrolytic circuit, who’s ionic medium is the urine,in contact with the positive pole(anode),through:
The ELLYS is effective on all types of stones
stones “hardness”
With a Dissolution rate
D. R. ( mg\h )
applied current intensity
“Hardness of stones
“Hardness” = resistance to electrochemical dissolution
It’s inversely proportional to dissolution rate (D.R.)
Hardness Dissolution rate
Hardness of main stone compounds
0102030405060708090
100
Oxalate Cystine Ac. Urico Phosphate
OxalateCystineAc. UricoPhosphate
Tas
so d
i dis
solu
zion
eM
g\h
Current intensity( mA )
Current intensity( mA )
The dissolution rate ( D.R. ) is directlyproportional to the current intensity (C.I.)
D.R. C.I. and more specifically to the current density
(C.D.),it is to the ratio between C.I.and electrode surface
D.R. C.D.
“In vitro”experimentation results“In vitro”experimentation results
The ELLYS is effective against :The ELLYS is effective against :
Urinary stones
Crystals and salts
Bacteria *
* Wong HY and Griffit D.P. : Iontophoresis in Medicine : Possible applications in Urology . Minim. Invasive Therapy ; 1993, 2.51
Results of “ex vivo trialResults of “ex vivo trial
C.I.employable without lesions = 30 mA
ELLYS effective at these C.I. values
Possible therapeuticapplications of ELLYS
Possible therapeuticapplications of ELLYS
Stone therapy
Therapy of kidney infected cavities
Prevention of urolithiasis
Equipment for ELLYSEquipment for ELLYS
Spiral stent Power Supplier
( S.EL.S.) ( battery and electronic circuit)+
Stone disease therapyStone disease therapy
Non impacted single or multiple stones into inferior calyx or pelvis
Residual fragments to E.S.W.L. Relapsing stone disease in multitreated patients
Prevention of stone diseasePrevention of stone disease
The ELLYS is very effective on growing crystals through:
Spiral miniaturized stent left in cavities (implant)and connected with a battery embedded in a sub- cutaneous pouch
Therapy of infectionsTherapy of infections
The continous current delivery in a saline solutionmakes it completely sterile through born
Oxygen and Chlorine( Wong e Coll. )
The continous current delivery in a saline solutionmakes it completely sterile through born
Oxygen and Chlorine( Wong e Coll. )
The ELLYS therefore can be employed :The ELLYS therefore can be employed :
To sterilize kidney infected cavities
To get the contemporary dissolution and sterilization of infected stones ( struvite )
The ELLYS want to realize , with the help of modern technologies, the old dream of the
Urologist ,that is the total stone disappearance
The ELLYS want to realize , with the help of modern technologies, the old dream of the
Urologist ,that is the total stone disappearance