The Effect of Adding Oral Simvastatin to Calcipotriol/Betamethasone Diproprionate Ointment for Treatment of Psoriasis

The Effect of Adding Oral Simvastatin to Calcipotriol/Betamethasone Diproprionate Ointmentfor Treatment of PsoriasisNguye Trong Hao, 1 Tran hau Khang, 1 Nguyen Tat Thang 31 Hospital od Dermato-venereology, Ho Chi Minh City, vietnam2National Hospital of Dermato-venereology, Vietnam3 Department of Dermatology, University of Medicine and Pharmacy, Ho chi Minh City, Vietnam. PsoriasisStatinsStatin: Mechanism of Action

StudyMethodsMethod (continued)Patient DistributionResultsTable 2

ResultsFigure 1DiscussionDiscussionLimited action of lymphocyteImpaired infiltration into inflammation sitesMore ReportsShirinsky et al., in Russia: 7 patients prescribed with Simvastatin 40mg/d for 8 weeks, evaluated at week4 and 8, using PASI and QLDI.Decreased PASIO score by 47,34% and downward in DLQI score.2 patients : 50% PASI response2 patients : 75% PASI responseStatins could have clinical utility in Psoriasis treatment

Reduction in PASI score was more expressed in patients receiving Simvastatin + topical 50% Betamethasone in petrolatum, no side effect

Decreased risk of Psoriasis associated with Statin intake (Wolkenstein et al. in France)

7 patients prescribed with Simvastatin 40mg/d for 8 weeks, evaluated at week4 and 8, using PASI and QLDI.Decreased PASIO score by 47,34% and downward in DLQI score.2 patients : 50% PASI response2 patients : 75% PASI response

13Psoriasis First line therapySimvastatinStudy LimitationConclusion